Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 16;3(2):oead010. doi: 10.1093/ehjopen/oead010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Transcriptome analysis of thoracic aorta from Ctrl and α_v^SMKO mice in basal conditions and in response to 4-week Ang II treatment. (A–B) Venn diagram showing the number of genes differentially expressed in α_v^SMKO vs. Ctrl, Ang II-treated α_v^SMKO vs. α_v^SMKO, and Ang II-treated Ctrl vs. Ctrl for upregulated and downregulated genes, respectively. (C) Volcano of plots of comparative of gene expression in Ang II-treated mice. (D) Heatmaps of top 15 differentially upregulated genes. (E) Gene ontology term and pathways enrichment for Ang II-treated Ctrl vs. Ctrl group and Ang II-treated α_v^SMKO vs. α_v^SMKO. Left bars indicate downregulated genes and right bars upregulated genes. The terms related to fibrosis (extracellular region, collagen trimer, collagen type V trimer, TGF-b signal transduction) are indicated in bold.