Table 1.
Alteration of the gene program in αvSMKO aortas
| Gene | Ctrl | αvSMKO | Ctrl Ang II | αvSMKO Ang II |
|---|---|---|---|---|
| Itgav | 1.01 ± 0.09 | 0.61 ± 0.05** | 1.62 ± 0.25* | 0.55 ± 0.07** |
| Itga5 | 1.02 ± 0.06 | 1.16 ± 0.13 | 1.97 ± 0.24** | 1.05 ± 0.09 |
| Itgb3 | 0.97 ± 0.04 | 0.94 ± 0.09 | 1.08 ± 0.08 | 0.63 ± 0.07** # |
| Col1a1 | 1.03 ± 0.07 | 0.71 ± 0.07** | 1.92 ± 0.34* | 1.28 ± 0.11### |
| Col1a2 | 0.97 ± 0.05 | 1.03 ± 0.07 | 1.63 ± 0.21** | 1.11 ± 0.06 |
| Col3a1 | 1.00 ± 0.05 | 1.04 ± 0.07 | 1.67 ± 0.25** | 1.08 ± 0.10 |
| Fn1 | 1.00 ± 0.06 | 1.06 ± 0.06 | 1.88 ± 0.45* | 0.86 ± 0.06 |
| Tgfb1 | 1.03 ± 0.04 | 0.90 ± 0.09 | 1.60 ± 0.24* | 1.02 ± 0.09 |
| Tgfb2 | 1.00 ± 0.06 | 1.13 ± 0.09 | 1.39 ± 0.11** | 1.24 ± 0.09 |
| Tgfb3 | 0.97 ± 0.05 | 1.07 ± 0.08 | 1.23 ± 0.06* | 0.90 ± 0.07 |
| Tgfbr2 | 1.00 ± 0.04 | 1.00 ± 0.04 | 0.96 ± 0.07 | 0.76 ± 0.06** # |
| Tgfbr3 | 1.00 ± 0.05 | 1.04 ± 0.03 | 0.72 ± 0.08** | 0.65 ± 0.07** ## |
| Smad2 | 0.99 ± 0.05 | 1.02 ± 0.04 | 1.06 ± 0.06 | 0.80 ± 0.06* # |
| Smad3 | 0.99 ± 0.04 | 0.89 ± 0.07 | 1.26 ± 0.10* | 0.74 ± 0.06** |
| Cd109 | 1.01 ± 0.04 | 1.16 ± 0.05 | 3.11 ± 0.49** | 2.46 ± 0.46*** ### |
Values are expressed as ratio relative to original Ctrl; n = 4–5 in each group. Ang II, angiotensin II; Ctrl, control mice. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Ctrl; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. αvSMKO.