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. 2023 Feb 23;14:1016872. doi: 10.3389/fmicb.2023.1016872

Figure 7.

Figure 7

Behavioral effects of intestinal microbiota derived from non-DS volunteers or individuals with DS and Prevotella copri in germ-free mice. (A–D) Behavior of mice treated with intestinal microbiota derived from non-DS volunteers or individuals with DS and Prevotella copri in sucrose preference, open field, and forced swimming tests. Mice treated with intestinal microbiota derived from individuals with DS or Prevotella copri exhibited reduced sucrose preference (A), reduced total distance traveled (open field test) (B), reduced time in center (open field test) (C), and increased immobility time (forced swimming test) (D). (E–G) Effects of intestinal microbiota derived from non-DS volunteers or individuals with DS and Prevotella copri on serum CRP (A), LPS (B), and corticosterone (C) levels. Each group contained 6 mice. The data are expressed as the mean ± SEM from one-way ANOVA followed by a post hoc test and Student’s t-test. *p < 0.05, and **p < 0.01.