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. 2023 Mar 9;12:e84740. doi: 10.7554/eLife.84740

Figure 4. Suppression of REM sleep following C21 injections.

(a) Time course of wakefulness, NREM, and REM sleep in the 6 hr following injection of C21 or saline at light onset (ZT 0). (b) Percentage of time spent in the three vigilance states during the first 2 hr (left column) and over the entire 6 hr observation period after saline and C21 injections. Note that REM sleep is presented both as proportion of the recording time (third row) and of the total sleep time (fourth row). n=7. Asterisks indicate t-tests with significant differences (*p<0.05, **p<0.01, ***p<0.001). C21: compound 21. NREM: non-rapid eye movement sleep. REM: rapid eye movement sleep. TST: total sleep time. ZT: zeitgeber time.

Figure 4.

Figure 4—figure supplement 1. Reduced REM/NREM ratio following C21 injections.

Figure 4—figure supplement 1.

(a) Time course of REM sleep expressed as the ratio between REM and NREM sleep over the 6 hr following intraperitoneal injections of C21 or saline at light onset (ZT 0). (b) REM/NREM ratio during the first 2 hr (left column) and over the entire 6 hr observation period (right column) after saline and C21 injections. n=7. Asterisks indicate t-tests with significant differences (*p<0.05, **p<0.01, ***p<0.001). C21: compound 21. NREM: non-rapid eye movement sleep. REM: rapid eye movement sleep. TST: total sleep time. ZT: zeitgeber time.