FIG. 1.

(A) Structure and biosynthesis of Man-containing L. mexicana glycoconjugates. (1), LPG; (2), PPG phosphoglycans; (3), protein GPI anchor; (4), GIPL iM3 (as an example); (5), protein N-glycan. Man residues added from Dol-P-Man are enlarged and underlined, while Man residues added from GDP-Man are in italics and bold. The indication of GDP-Man and Dol-P-Man as Man donors for the biosynthesis of different Leishmania glycoconjugates is based on earlier studies (references 8 and 22 and references therein). (B) Man biosynthesis and activation pathways and glycoconjugate synthesis in L. mexicana. Bold arrows mark the enzymes that are the topic of this study.