TABLE 1.

Glycosylation defects and virulence phenotypes of L. mexicana mutants

L. mexicana line	Virulence to macrophages and micea	Defect(s) in glycoconjugate synthesis	Reference(s)
WT	++	Normal expression of all Man-containing glycoconjugates (LPG., PPGs, protein GPIs, Man-containing GIPIs, N-glycans)	This study; 12, 15, 16, 21
Δlmexlpg1	++	No expression of LPG	16
Δlmexlpg2	++	No expression of LPG and no phosphoglycosylation of PPGs (except for small amounts of PPG manno-oligosaccharide caps)	21
ΔGPI18	++	No expression of protein GPIs	15
ΔGDPMP	−	No expression of LPG, protein GPIs, Man-containing GIPLs and N-glycans, and no phosphoglycosylation of PPGs	12
ΔPMM	−	Severely downregulated expression of LPG, protein GPIs, Man-containing GIPLs, and N-glycans, and downregulated phosphoglycosylation of PPGs	This study
ΔDPMS	+	No expression of LPG, protein GPI anchors, and Man-containing GIPLs	This study

^a++, fully virulent (no difference to wild type); +, virulent, but attenuated (lower efficiency of infection); −, avirulent (no infectivity).