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. 2001 Dec;21(23):8184–8188. doi: 10.1128/MCB.21.23.8184-8188.2001

FIG. 2.

FIG. 2

Analysis of marker gene expression in Sna−/− mutant embryos at E7.5. (A and B) T expression. T is expressed in axial mesoderm cells, and expression extends rostrally from the node (A). In the Sna−/− embryo, T is expressed, but at lower levels than in the control embryos, and does not extend as far rostrally in the embryo (B). (C and D) Lim1 expression. Lim1 is expressed in the primitive streak and the mesodermal wings (C). Lim1 is expressed in these tissues in the Sna−/− embryo (D). (E and F) Otx2 expression. Otx2 is expressed in the visceral endoderm and epiblast, and expression is gradually restricted to the anterior third of the embryo as the primitive streak extends (E). In the Sna−/− mutant, Otx2 expression is not restricted to the anterior portion of the embryo (F). (G and H) Cer1 expression. Cer1 is expressed in the anterior visceral endoderm and the definitive endoderm (G). In the Sna−/− embryos, Cer1 expression is reduced (H). All embryos are oriented with the anterior side towards the left.