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. 2023 Mar 9;3(1):8. doi: 10.1007/s44192-023-00031-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Comparative gene expression analysis of cerebral organoids differentiated from iPSCs of subjects with schizophrenia and bipolar disorder. A Heatmaps of differentially expressed genes (DEGs) of 6-month-old cerebral organoids generated from iPSCs of eight SCZ and eight BPI subjects. B Principal Component Analysis (PCA) of DEGs of SCZ and BPI cerebral organoids. C Gene ontology (GO) analysis of DEGs for SCZ vs BPI. GO analyses for biological process, molecular function and cellular component/protein localization are rank-ordered according to significance (p value) for the top 10 categories—categories up-regulated in SCZ are depicted in black and categories up-regulated in BPI are depicted in orange