Table 1.
Gene set enrichment analysis
| Size | ES | NES | NOM p-val | FDR q-val | FWER p-val | Rank at max | Leading edge | |
|---|---|---|---|---|---|---|---|---|
| Reactome | ||||||||
| Reactome_Influenza_Infection | 154 | − 0.59132 | − 2.80241 | 0 | 0 | 0 | 10,503 | tags = 73%, list = 27%, signal = 99% |
| Reactome_Mitochondrial_Translation | 93 | − 0.60753 | − 2.62088 | 0 | 0 | 0 | 13,391 | tags = 86%, list = 34%, signal = 131% |
| Reactome_Respiratory_Electron_Transport | 89 | − 0.60034 | − 2.61611 | 0 | 0 | 0 | 12,856 | tags = 84%, list = 33%, signal = 125% |
| Reactome_Infectious_Disease | 371 | − 0.49008 | − 2.60519 | 0 | 0 | 0 | 13,579 | tags = 68%, list = 35%, signal = 103% |
| Reactome_Cell_Cycle_Checkpoints | 282 | − 0.51048 | − 2.60441 | 0 | 0 | 0 | 15,024 | tags = 74%, list = 39%, signal = 120% |
| Reactome_Naplus_Cl_Dependent_Neurotransmitter_Transporters | 19 | 0.515474 | 1.541765 | 0.038388 | 0.66119 | 1 | 1466 | tags = 32%, list = 4%, signal = 33% |
| Reactome_Role_Of_Phospholipids_In_Phagocytosis | 33 | 0.452627 | 1.529319 | 0.032136 | 0.623584 | 1 | 4477 | tags = 24%, list = 11%, signal = 27% |
| Reactome_Plasma_Lipoprotein_Assembly | 19 | 0.504823 | 1.504998 | 0.043222 | 0.652722 | 1 | 2605 | tags = 32%, list = 7%, signal = 34% |
| Reactome_Xenobiotics | 24 | 0.466743 | 1.485898 | 0.049904 | 0.666401 | 1 | 8655 | tags = 50%, list = 22%, signal = 64% |
| Reactome_Long_Term_Potentiation | 23 | 0.474369 | 1.470371 | 0.046693 | 0.608513 | 1 | 8104 | tags = 48%, list = 21%, signal = 60% |
| Hallmark | ||||||||
| Hallmark_Myogenesis | 199 | − 0.55399 | − 2.73616 | 0 | 0 | 0 | 5986 | tags = 43%, list = 15%, signal = 51% |
| Hallmark_E2F_Targets | 198 | − 0.51894 | − 2.56449 | 0 | 0 | 0 | 13,107 | tags = 65%, list = 34%, signal = 98% |
| Hallmark_Oxidative_Phosphorylation | 185 | − 0.52698 | − 2.53241 | 0 | 0 | 0 | 13,844 | tags = 71%, list = 36%, signal = 109% |
| Hallmark_Unfolded_Protein_Response | 111 | − 0.43549 | − 1.96044 | 0 | 0 | 0 | 14,339 | tags = 65%, list = 37%, signal = 102% |
| Hallmark_Glycolysis | 198 | − 0.38222 | − 1.88766 | 0 | 0 | 0 | 13,694 | tags = 57%, list = 35%, signal = 87% |
| Hallmark_Pancreas_Beta_Cells | 40 | 0.268541 | 0.960266 | 0.515539 | 1 | 1 | 2039 | tags = 10%, list = 5%, signal = 11% |
| Hallmark_Spermatogenesis | 132 | 0.17472 | 0.771267 | 0.937394 | 1 | 1 | 9809 | tags = 27%, list = 25%, signal = 36% |
| Hallmark_Xenobiotic_Metabolism | 200 | 0.164059 | 0.76698 | 0.98087 | 0.93739 | 1 | 5051 | tags = 12%, list = 13%, signal = 13% |
| KEGG | ||||||||
| KEGG_Ribosome | 86 | − 0.66314 | − 2.80034 | 0 | 0 | 0 | 10,890 | tags = 93%, list = 28%, signal = 129% |
| KEGG_Parkinsons_Disease | 99 | − 0.50716 | − 2.26377 | 0 | 0 | 0 | 13,694 | tags = 75%, list = 35%, signal = 115% |
| KEGG_Oxidative_Phosphorylation | 100 | − 0.51326 | − 2.26148 | 0 | 0 | 0 | 13,763 | tags = 71%, list = 35%, signal = 109% |
| KEGG_Small_Cell_Lung_Cancer | 84 | − 0.50382 | − 2.18709 | 0 | 0 | 0 | 8917 | tags = 50%, list = 23%, signal = 65% |
| KEGG_P53_Signaling_Pathway | 67 | − 0.52866 | − 2.14187 | 0 | 9.17E−04 | 0.003 | 12,063 | tags = 64%, list = 31%, signal = 93% |
| KEGG_Taste_Transduction | 51 | 0.457469 | 1.688169 | 0.001692 | 0.234029 | 0.361 | 7615 | tags = 49%, list = 20%, signal = 61% |
| KEGG_Linoleic_Acid_Metabolism | 28 | 0.510943 | 1.677292 | 0.011858 | 0.129439 | 0.388 | 8626 | tags = 43%, list = 22%, signal = 55% |
| KEGG_Type_I_Diabetes_Mellitus | 42 | 0.433637 | 1.558308 | 0.012797 | 0.188571 | 0.766 | 8960 | tags = 43%, list = 23%, signal = 56% |
| KEGG_Asthma | 29 | 0.486376 | 1.629667 | 0.013619 | 0.132661 | 0.538 | 8960 | tags = 52%, list = 23%, signal = 67% |
| KEGG_Retinol_Metabolism | 64 | 0.358277 | 1.385493 | 0.043956 | 0.410179 | 0.994 | 7681 | tags = 28%, list = 20%, signal = 35% |
Gene set enrichment analysis (GSEA) data for DEGs using three different databases (Hallmark, KEGG, Reactome) tabulated according to normalized enrichment score (NES) and False discovery rate (FDR) q-value. Positive correlation indicates relative association with gene expression in bipolar disorder and a negative correlation indicates relative association with gene expression in schizophrenia