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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Gut. 2022 Oct 3;72(4):654–662. doi: 10.1136/gutjnl-2021-326305

Figure 3. NOX1- and TNFα-modulated transcription factor expression is predominant in UC stem cells.

Figure 3

A. Violin plot of transcription factors showing differential expression in inflamed vs. uninflamed tissue and being differentially expressed (without TNFα) by genotype. TNFα-stimulated differences for Nox1WT (first row) and Nox1KO (second row) colonoids. Genotype dependent differences without (third row) and with (forth row) TNFα stimulation. Ns, non-significant. *, P<0.05. ****, P < 0.0001 (two-sided Wilcoxon signed-rank test). B. Feature plot of induced transcription factors projected onto UMAP from UC epithelial cells (see Figure 2A for cell annotation).