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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Immunol. 2023 Mar 1;210(5):609–617. doi: 10.4049/jimmunol.2200463

FIGURE 5.

FIGURE 5.

Composition 8203 augments absolute expansion of Treg cells via MMΦs. (A) Clodronate liposomes (“CL”) reduce OVA-in-8203-induced influx of MMΦs into DLN. CL was injected i.v. on days 4–6, and OVA-in-8203 was injected at the primed footpad on day 5. MMΦs in the DLN were counted on the indicated days. Data are mean ± SD of four experiments. *p ≤ 0.002 versus plain liposomes (“Liposome”) (one-way ANOVA). (B) CL diminishes the effect of 8203 on absolute expansion of Treg cells in DLN (analyzed on day 8). Mice in A were analyzed for KJ1-26+ Treg cells in the same DLN on day 8. Data are mean ± SD of six experiments. *p ≤ 0.02 (one-way ANOVA).