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. 2023 Mar 9;13:3934. doi: 10.1038/s41598-023-31141-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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L-Moses attenuates Tun-mediated effects on cortical neurons. (A,B) Co-treatment with L-Moses significantly increases viability of 100 nM Tun-treated samples, as judged by cell counting (A) and MTS assay (B). (C) L-Moses reduces Tun-mediated response (Tun-treated minus Unt MFI) in the CHOP reporter lines, in a dose-dependent manner. (D) Time-course showing that L-Moses effect is reduced with continuous exposure to 100 nM Tun, using both homozygote clonal lines (518 and 535). (E,F) Western blot confirming reduces RFP levels in Tun + L-Moses treated samples, when compared to Tun-treated. Original blots are presented in Supplementary Fig. S7. (G) Significant rescue in viability, following L-Moses treatment, was observed in cortical neurons derived from an independent iPSC cell line (Ward lab). One-way ANOVA with Dunnett’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 compared to 100 nM Tun only control (blue bar).