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. 2023 Mar 9;13:3934. doi: 10.1038/s41598-023-31141-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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L-Moses attenuates Tun-mediated transcriptional changes on dopaminergic neurons. (A) Co-treatment with L-Moses rescues Tun-mediated cell death in a dose dependent manner, as shown by MTS assay. (B) L-Moses reduces Tun response (Tun-treated minus Unt MFI) in a dose dependent manner. (C) Circos plot showing the overlap (purple lines) between genes upregulated by Tun and downregulated by Tun + L-Moses and vice versa. (D) Hierarchical clustering of GO Biological Processes terms upregulated or downregulated in Tun versus Tun + L-Moses. (E) GO Biological Processes terms enriched in the genes that overlap between the ones upregulated by 100 nM Tun and downregulated by Tun + L-Moses.