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. 2023 Mar 10;14:1307. doi: 10.1038/s41467-023-37020-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Flow cytometry analysis of the cellular dynamic uptake of mRNA nano-lantern in SW480 cells at different time points, n = 3 independent biological samples, data are presented as the mean ± SEM. The gating strategy was provided in the Supplementary Fig. 16b. b Representative confocal images of SW480 cells incubated with mRNA nano-lantern at different time points, the images at each time point are from 3 independent experiments. Fluorophore Cy5 was exploited to label the RGD-CS RNA and the FITC was exploited to label the mRNA scaffold. The spearman correlation coefficient (r) is calculated by Image J software to evaluate the association of Lysotraker and mRNA. c Representative confocal images of SW480 cells incubated with individual Smad4 mRNA, lipo + mRNA, and nano-lantern, respectively, from 3 independent experiments. Scale bar: 20 μm. Panel (c) created with BioRender.com. Source data are provided as a Source Data file.