Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 10;14:1307. doi: 10.1038/s41467-023-37020-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 9 — a Systematic schedule of Smade4 mRNA nano-lantern administration in the orthotopic model of SW480-Luc cells. Created with BioRender.com. b Representative bioluminescence imaging of tumor burden and fluorescence imaging of Cy5-mRNA nano-lantern in tumor-bearing nude mice. c Ex vivo images of the xenograft tumors at the endpoint. d IL-6 and INF-β levels in peripheral blood of tumor bearing mice after 6 h post-intraperitoneal injection of different formulations (n = 4 mice/group). e Representative IHC staining for Smad4 in tumor tissues from 4 mice/group. Scale bar: 100 μm. f Representative H&E staining of organs and tumor tissues in the tumor-bearing mice from 4 mice/group. Scale bar: 100 μm. g Representative western blot analysis of Smad4, MYC, VEGFC, and CXCL5 expression in orthotopic tumors from 4 independent experiments. Data are presented as the mean ± SEM. Statistical differences were assessed using one-way ANOVA with Bonferroni multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source Data file.