Table 2.

Review of evidence of clozapine use in childhood psychosis.

References	Drugs	Key findings	Remarks on side effects
Kumra et al. (33)	Haloperidol vs. clozapine	Clozapine outperforms haloperidol in terms of both positive and negative symptom control.	Sedation, drooling, and temporary neutropenia were the reported side effects.
Shaw et al. (34)	Olanzapine vs. clozapine	Clozapine showed superior response in mitigating negative symptoms, as measured by SANS score as compared to Olanzapine	Despite reports of increased heartrate and Blood Pressure and enuresis with clozapine, no children were removed from the trial. They found tachycardia in 70% of patients, but no change in blood pressure.
Sporn et al. (35)		NDMC, a clozapine metabolite, was favorably linked with clinical improvement when examined as an NDMC/clozapine ratio	Increased side effects in youngsters than adults, but they could not predict these events.
Kumra et al. (36)	High dose olanzapine vs. clozapine	Among treatment-refractory patients, clozapine had a 66% response rate vs. 33% for olanzapine.	More advantage at a dose of 30 mg/day Olanzapine.
Kumra et al. (36)	Olanzapine to clozapine switchers	70% of olanzapine-refractory individuals reacted to clozapine in an extended study.	Clozapine can cause a range of metabolic adverse effects.