Table 3.
Table showing comparison of MultiPlane performance to biometry-based methods of gestational age estimation throughout gestation.
| Biometry | MultiPlane | |||
|---|---|---|---|---|
| Hadlock16 (BPD, HC, AC, FL) | INTERGROWTH-21st7 (HC & FL) | |||
| INTERGROWTH-21st Internal Validation (424 patients) | 14+0–19+6 weeks | 2.6 (2.5 to 2.8) | 2.1 (1.9 to 2.3) | 2.6 (2.4 to 2.8) |
| 20+0–25+6 weeks | 3.5 (3.2 to 3.7) | 3.2 (2.9 to 3.4) | 3.1 (2.8 to 3.3) | |
| 26+0–31+6 weeks | 4.8 (4.5 to 5.1) | 4.8 (4.4 to 5.1) | 3.3 (3.1 to 3.5) | |
| 32+0–37+6 weeks | 8.3 (7.8 to 8.9) | 7.4 (6.8 to 8.0) | 4.6 (4.3 to 4.9) | |
| ≥38+0 weeks | 15.5 (13.8 to 17.3) | 11.7 (10.0 to 13.5) | 5.4 (4.5 to 6.2) | |
| 14+0–42+0 weeks | 5.6 (5.3 to 5.8) | 4.9 (4.6 to 5.1) | 3.5 (3.4 to 3.7) | |
| INTERBIO-21st External Validation (2304 patients) | 14+0–19+6 weeks | 2.3 (2.3 to 2.4) | 2.5 (2.4 to 2.6) | 2.9 (2.8 to 3.0) |
| 20+0–25+6 weeks | 4.0 (3.9 to 4.1) | 3.6 (3.5 to 3.7) | 3.8 (3.6 to 3.9) | |
| 26+0–31+6 weeks | 5.4 (5.3 to 5.5) | 5.5 (5.4 to 5.7) | 4.1 (4.0 to 4.3) | |
| 32+0–37+6 weeks | 8.7 (8.4 to 8.9) | 7.9 (7.7 to 8.2) | 5.2 (5.0 to 5.4) | |
| ≥38+0 weeks | 13.9 (13.2 to 14.5) | 10.6 (9.7 to 11.4) | 7.5 (6.4 to 8.7) | |
| 14+0–42+0 weeks | 5.7 (5.6 to 5.7) | 5.3 (5.2 to 5.4) | 4.1 (4.0 to 4.2) | |
| SGA cohort from INTERBIO-21st (326 patients) | 14+0–19+6 weeks | 1.8 (1.7 to 2.0) | 2.0 (1.8 to 2.1) | 2.7 (2.4 to 3.1) |
| 20+0–25+6 weeks | 3.5 (3.3 to 3.7) | 2.8 (2.6 to 3.0) | 3.2 (2.7 to 3.6) | |
| 26+0–31+6 weeks | 4.7 (4.4 to 5.0) | 4.4 (3.8 to 4.9) | 3.6 (3.2 to 3.9) | |
| 32+0–37+6 weeks | 7.4 (6.9 to 8.0) | 6.3 (5.8 to 6.9) | 4.7 (4.2 to 5.1) | |
| ≥38+0 weeks | 15.6 (13.4 to 17.8) | 11.8 (9.1 to 14.4) | 4.6 (3.2 to 5.9) | |
| 14+0–42+0 weeks | 5.0 (4.7 to 5.2) | 4.4 (4.1 to 4.7) | 3.7 (3.5 to 3.9) | |
| LGA cohort from INTERBIO-21st (201 patients) | 14+0–19+6 weeks | 2.3 (2.0 to 2.6) | 2.5 (2.2 to 2.8) | 3.3 (2.5 to 4.0) |
| 20+0–25+6 weeks | 4.2 (3.8 to 4.6) | 3.5 (3.1 to 3.8) | 4.6 (3.6 to 5.5) | |
| 26+0–31+6 weeks | 5.9 (5.4 to 6.5) | 4.8 (4.2 to 5.3) | 5.1 (4.3 to 5.8) | |
| 32+0–37+6 weeks | 10.6 (9.7 to 11.5) | 7.9 (6.8 to 9.0) | 5.3 (4.5 to 6.1) | |
| ≥38+0 weeks | 15.3 (9.2 to 21.5) | 10.2 (5.9 to 14.5) | Insufficient data | |
| 14+0–42+0 weeks | 6.2 (5.8 to 6.6) | 4.9 (4.5 to 5.3) | 4.7 (4.3 to 5.1) | |
Table showing performance of MultiPlane and current biometry methods used for estimating gestational age throughout gestation. Figures shown are mean absolute error (MAE) in days with the 95% confidence interval for the MAE in parenthesis. BPD Biparietal Diameter, HC Head Circumference, AC Abdominal Circumference, FL Femur Length, SGA Small for Gestational Age, LGA Large for Gestational Age.