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. 2022 Nov 30;8(2):174–185. doi: 10.1016/j.jacbts.2022.08.003

Figure 2.

Figure 2

IL-1β Mediates HFD-Induced Diastolic Dysfunction

(A) Cardiac interleukin (IL)-1β level tested by enzyme-linked immunosorbent assay was increased in the mice with HFD; n = 8 to 9 mice per group. (B) IL-1β antagonist improved E/E′ in HFD mice; n = 11 to 14 mice per group. (C) The EF remained unchanged after IL1RA treatment; n = 11 to 14 mice per group. (D) Other cytokines in hearts were tested by enzyme-linked immunosorbent assay; n = 10 to 12 mice per group. Bars are mean ± SEM. Unpaired t-test (A and D) or 1-way analysis of variance with Bonferroni post hoc tests (B and C) were used. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001 vs Ctrl; §P < 0.05 vs HFD. IL1RA = interleukin 1 receptor antagonist; TGF = transforming growth factor; TNF = tumor necrosis factor; other abbreviations as in Figure 1.