Table 1.
RNA-seq data used in the study.
| Descriptive information on RNA-seq samples | ||
|---|---|---|
| Human | Primate | |
| Data source | PRJNA530758; PRJNA551775; PRJNA551908; PRJNA551909 | GSE96731; GSE144783 |
| GSE96732 | ||
| n | 56 | 53 |
| Traits | 53.57% AUD | 16.98% Very high drinkers, 20.75% high drinkers |
| 13.2% Binge drinkers, 33.96% low drinkers and 15.09% Naïve | ||
| Brain regions | sPFC, NAc, BLA and CEA | PFC (Area 32), NAc core and CEA |
| Age | M = 57.34 (s.d. = 8.91) | 4–11 years |
| Sex | 76.79% | 100% Male |
| Brain pH | 6.60 (s.d. = 0.25) | NA |
| PMI | M = 32.81 (s.d. = 13.75) | < 1 h |
| Cigarette smoker | 67.86% | 0% |
Primate samples lacked information on brain pH AUD includes both DSM-IV diagnoses of alcohol abuse (two thirds of AUD cases) and alcohol dependence (one third of AUD cases). PMI stands for post-mortem interval or the # of hours since death until brain tissue was frozen or processed.