Figure 5.

Cardiac Histologic and Magnetic Resonance Imaging Assessments Pertaining to Case 2

(A) Histopathologic examinations of the endomyocardial biopsy specimens from the RV. Hematoxylin and eosin staining (upper left) and its enlarged image (upper right) showed cell infiltration of mononuclear cells with cardiomyocyte necrosis. Masson-trichrome staining (lower left) showed replacement fibrosis, and CD3 staining (lower right) demonstrated infiltration of CD3-positive cells into the myocardium. (B) Cardiac magnetic resonance imaging. Cine imaging in the end-diastolic phase (upper left) and end-systolic phase (upper right) revealed impaired left ventricular function (LVEF 20%), and late gadolinium enhancement imaging (short-axis, lower left; long-axis, lower right) showed diffuse endocardial late gadolinium enhancement involvement in the LV. LV = left ventricle; LVEF = left ventricular ejection fraction; RV = right ventricle.