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. 2023 Feb 23;220(5):e20221563. doi: 10.1084/jem.20221563

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© 2023 Wei et al.

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Figure 6. — INPPL1-, MAP4K5-, or LZTR1-KO MV4-11 cells are resistant to SHP099 in vivo. (A) Workflow for mouse experiments. (B) Bioluminescence imaging of mice injected with parental and INPPL1-, MAP4K5-, LZTR1-KO MV4-11 cells on day 0 and monitored for 21 d. Note increased tumor burden caused by each KO line. (C) Quantification of data in B by Student’s t test. (D) Deletion of INPPL1, MAP4K5, or LZTR1 in MV4-11 cells significantly shortens survival of mice. **, P < 0.01; ***, P < 0.001; Mantel log-rank test.