Figure 4.

Mechanisms by which T cell intrinsic NFκB signaling could contribute to establish T cell memory outcome. (A) An activated antigen specific T cell acquires effector function and can either choose the fate of a long-lived memory T cell or die as a short lived effector T cell (T cell fate choice). Becoming a memory T cell involves the ability of rapid re-activation of effector functions and sustained survival. These two features may be regulated independently by NFκB signaling. Meanwhile, memory T cell precursors also differentiate into different T cell memory subsets: circulating central memory (T_CM) and effector memory (T_EM) cells or tissue resident memory (T_RM) cells. The three subsets may be regulated independently by NFκB signaling. Processes that can contribute to determine these T cell memory choices are illustrated in yellow boxes. (B) Model for how NFκB signaling could regulate memory effector function and memory survival through different mechanisms.