Table 4.
Multivariate linear regression analysis of different types of obesity with insulin secretion and sensitivity.
| FPIS | SPIS | HOMA2-β | HOMA2-IR | Gutt-ISI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Standard β (CI) | p | Standard β (CI) | p | Standard β (CI) | p | Standard β (CI) | p | Standard β (CI) | p | |
| Model 1 | ||||||||||
| Normal weight-normal VF (Reference) | 0 | 0 | 0 | 0 | 0 | |||||
| Normal weight-high VF | 0.085 (-3.989, 22.384) |
NS | 0.023 (-1.368, 1.996) |
NS | 0.079 (-7.223, 33.207) |
NS | 0.075 (-0.148, 0.684) |
NS | -0.033 (-20.420, 11.827) |
NS |
| Overweight/obese-normal VF | 0.029 (-8.604, 13.797) |
NS | 0.013 (-1.282, 1.575) |
NS | 0.121 (-.875, 33.468) |
NS | 0.059 (-0.180, 0.527) |
NS | -0.022 (-16.124, 11.267) |
NS |
| Overweight/obese-high VF | 0.215 (5.369, 23.393) |
0.002 | 0.027 (-0.921, 1.377) |
NS | 0.125 (-1.146, 26.487) |
NS | 0.369 (0.529, 1.097) |
< 0.001 | -0.227 (-29.616, -7.577) |
0.001 |
| Model 2 | ||||||||||
| Normal weight-normal VF | -0.037 (-13.797, 8.604) |
NS | -0.017 (-1.575, 1.282) |
NS | -0.154 (-33.468, 0.875) |
NS | -0.075 (-0.527, 0.180) |
NS | 0.028 (-11.267, 16.124) |
NS |
| Normal weight-high VF | 0.061 (-8.072, 21.274) |
NS | 0.012 (-1.704, 2.039) |
NS | -0.020 (-25.800, 19.191) |
NS | 0.027 (-0.368, 0.557) |
NS | -0.014 (-19.809, 16.074) |
NS |
| Overweight/obese-normal VF(Reference) | 0 | 0 | 0 | 0 | 0 | |||||
| Overweight/obese-high VF | 0.176 (0.779, 22.790) |
0.036 | 0.010 (-1.322, 1.485) |
NS | -0.036 (-20.498, 13.246) |
NS | 0.290 (0.293, 0.987) |
< 0.001 | -0.197 (-29.625, -2.711) |
0.019 |
VF, visceral fat; FPIS, first phase insulin secretion; SPIS, second phase insulin secretion; IR, insulin resistance; ISI, insulin sensitivity index; NS, no significance.
For all the models, FPIS, SPIS, HOMA2-β, HOMA2-IR and Gutt-ISI were used as dependent variables. Independent variables included gender, diabetes duration, normal weight-normal VF (as reference group in Model 1), Normal weight-high VF, Overweight/obesity-normal VF (as reference group in Model 2), and Overweight/obesity-high VF.