Table 2.
Age-adjusted comparison between PwH and controls for annual use of drug types for treatment of pain, depression, and anxiety. Results presented by subgroups. Longitudinal regression analysis of annual data on the use of drug type (OR [95% CI]) and volume of drug types (% difference [P value] if use > 0) among people with ≥1 filled prescription from Denmark (2007-2016) and Finland and Sweden (2007-2017).
| Drug type | Denmark |
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|---|---|---|---|---|---|---|
| Moderate-high factor consumption PwH: n = 221; person-years = 1293 Control: n = 1049; person-years = 6085 |
Low factor consumption PwH: n = 554; person-years = 3826 Control: n = 2677; person-years = 17,902 |
Women including carriers PwH: n = 295; person-years = 1765 Control: n = 1448; person-years = 8384 |
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| Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | |
| Opioids | 6.57 (4.69-9.19) | 51.2 (.008) | 2.33 (1.89-2.88) | 21.8 (.19) | 2.58 (1.97-3.39) | 57.8 (.003) |
| Nonopioids | 3.43 (2.45-4.79) | 22.1 (.13) | 1.64 (1.34-2.02) | 7.8 (.31) | 1.40 (1.10-1.80) | 17.9 (.07) |
| NSAIDs | 1.14 (0.81-1.60) | 61.2 (<.001) | 0.71 (0.59-0.87) | 24.4 (.03) | 0.77 (0.60-0.98) | −3.4 (.71) |
| Steroids | 1.26 (0.68-2.33) | −10.4 (.79) | 1.77 (1.30-2.42) | 57.8 (.001) | 2.26 (1.56-3.27) | 79.1 (<.001) |
| Neuroleptics | 1.36 (0.83-2.22) | 14.5 (.65) | 1.65 (1.29-2.12) | 2.4 (.90) | 1.61 (1.17-2.21) | 18.2 (.28) |
| Antidepressants | 2.26 (1.34-3.81) | 39.4 (.07) | 1.48 (1.09-2.01) | 19.0 (.16) | 1.29 (0.92-1.81) | −9.6 (.49) |
| Antiepileptics | 2.01 (0.99-4.08) | −21.6 (.60) | 0.80 (0.48-1.34) | 13.1 (.67) | 1.24 (0.70-2.19) | −61.3 (.03) |
| Drug type | Finland |
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|---|---|---|---|---|---|---|
| Moderate-high factor consumption PwH: n = 200; person-years = 1167 Control: n = 972; person-years = 5661 |
Low factor consumption PwH: n = 239; person-years = 1678 Control: n = 1170; person-years = 8079 |
Women including carriers (unadjusted) PwH: n = 7; person-years = 66 Control: n = 35; person-years = 323 |
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| Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | |
| Opioids | 5.64 (3.75-8.50) | 127 (<.001) | 4.33 (3.17-5.91) | 89.9 (<.001) | 8.13 (2.05-32.22) | 85.6 (.34) |
| Nonopioids | 3.35 (2.35-4.79) | 23.7 (.006) | 2.84 (2.11-3.82) | −2.1 (.79) | 4.42 (1.75-11.12) | 42.4 (.27) |
| NSAIDs | 1.48 (1.10-2.00) | 65.6 (<.001) | 1.06 (0.83-1.36) | 58.3 (<.001) | 1.82 (0.73-4.53) | 69.1 (.001) |
| Steroids | 1.01 (0.52-1.97) | −14.1 (.51) | 1.02 (0.56-1.88) | 27.3 (.14) | 0.48 (0.12-1.91) | −57.2 (.31) |
| Neuroleptics | 1.97 (1.11-3.50) | 40.2 (.260) | 1.27 (0.79-2.04) | 2.2 (.95) | 1.81 (0.39-8.34) | 29.2 (.71) |
| Antidepressants | 0.78 (0.39-1.56) | −31.5 (.185) | 0.95 (0.55-1.63) | 23.6 (.26) | 0.60 (0.20-1.79) | −157 (.007) |
| Antiepileptics | 3.08 (1.27-7.47) | 19.0 (.676) | 1.28 (0.58-2.83) | −49.8 (.21) | 0.66 (0.11-3.90) | −218 (.03) |
| Drug type | Sweden |
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|---|---|---|---|---|---|---|
| Moderate-high factor consumption PwH: n = 419; person-years = 2960 Control: n = 2072; person-years = 14,565 |
Low factor consumption PwH: n = 1016; person-years = 8869 Control: n = 4968; person-years = 42,649 |
Women including carriers PwH: n = 389; person-years = 3977 Control: n = 1920; person-years = 19,438 |
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| Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | Use; OR (95% CI) | % Difference in volume (P value) if use > 0 | |
| Opioids | 4.70 (3.69-6.00) | 105.8 (<.001) | 2.51 (2.17-2.90) | 25.6 (.02) | 2.40 (1.93-2.99) | 33.9 (.04) |
| Nonopioids | 5.64 (4.44-7.17) | 19.2 (.09) | 2.19 (1.89-2.54) | 10.9 (.02) | 2.13 (1.74-2.60) | 18.1 (.01) |
| NSAIDs | 3.20 (2.59-3.96) | 68.2 (<.001) | 1.26 (1.09-1.45) | 38.7 (<.001) | 1.17 (0.96-1.41) | 21.3 (.05) |
| Steroids | 3.00 (2.28-3.96) | 2.3 (.90) | 1.62 (1.32-1.97) | 19.2 (.05) | 2.42 (1.86-3.16) | 35.6 (.002) |
| Neuroleptics | 2.08 (1.55-2.80) | −6.0 (.75) | 1.61 (1.36-1.92) | 19.8 (.04) | 1.56 (1.24-1.95) | 11.3 (.37) |
| Antidepressants | 1.51 (1.00-2.30) | −4.2 (.81) | 1.30 (1.03-1.62) | −17.6 (.06) | 1.41 (1.09-1.82) | −0.8 (.94) |
| Antiepileptics | 2.87 (1.65-5.00) | 45.4 (.13) | 1.84 (1.31-2.58) | 1.2 (.95) | 1.59 (0.96-2.63) | 17.2 (.60) |
NSAIDs, nonsteroidal anti-inflammatory drugs; OR, odds ratio; PwH, people with hemophilia.