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. Author manuscript; available in PMC: 2023 Apr 5.
Published in final edited form as: Behav Brain Res. 2022 Aug 31;436:114087. doi: 10.1016/j.bbr.2022.114087

Figure 4. The Effect of Naloxone Pre-Treatment on Alcohol-Induced Antinociception.

Figure 4.

Antinociception effect of 2 g/kg alcohol after pre-treatment with 2 mg/kg naloxone, measured in the hot plate test as expressed by %MPE (Maximum possible effect) 30 min after alcohol gavage in (A) in B6 male mice and (B) D2 male mice. Values are expressed as mean ± SEM. n= 8/group. Results were compared using one-way ANOVA with treatment as the factor and post-hoc Tukey’s test (****p<0.0001 vs. vehicle).