Table 2. Clinical Course of SARS-CoV-2–Infected Children by Variant of Concern at Index ED Visit or Within 14-Day Follow-up Period.
| Course | Variant, No./total No. (%) | P value | ||||
|---|---|---|---|---|---|---|
| All patients (N = 1440) | Original type (n = 409) | Alpha (n = 242) | Delta (n = 321) | Omicron (n = 468) | ||
| Outcomes | ||||||
| Admitted to hospital | 164/1440 (11.4) | 52/409 (12.7) | 18/242 (7.4) | 33/321 (10.3) | 61/468 (13.0) | .23 |
| Admitted to ICU | 9/1440 (0.6) | 3/409 (0.7) | 3/242 (1.2) | 2/321 (0.6) | 1/468 (0.2) | .50 |
| Any revisit | 376/1250 (30.1) | 120/372 (32.3) | 68/214 (31.8) | 72/267 (27.0) | 116/397 (29.2) | .53 |
| ED revisit | 192/1250 (15.4) | 53/372 (14.2) | 37/214 (17.3) | 27/267 (10.1) | 75/397 (18.9) | .04 |
| Hospitalized at revisit | 29/1440 (2.0) | 12/409 (2.9) | 3/242 (1.2) | 5/321 (1.6) | 9/468 (1.9) | .53 |
| Died | 0/407 | 0/242 | 0/317 | 0/465 | 0/407 | NA |
| Chest radiography and treatments | ||||||
| Chest radiography | 228/1433 (15.9) | 69/407 (17.0) | 27/242 (11.2) | 35/317 (11.0) | 97/467 (20.8) | .004 |
| Intravenous fluids | 166/1430 (11.6) | 50/406 (12.3) | 14/242 (5.8) | 31/319 (9.7) | 71/463 (15.3) | .01 |
| Oxygen | 22/1428 (1.5) | 5/406 (1.2) | 1/242 (0.4) | 7/318 (2.2) | 9/462 (1.9) | .45 |
| Antibiotics | 213/1433 (14.9) | 62/406 (15.3) | 27/242 (11.2) | 54/319 (16.9) | 70/466 (15.0) | .45 |
| Corticosteroids | 180/1429 (12.6) | 38/405 (9.4) | 29/242 (12.0) | 31/318 (9.7) | 82/464 (17.7) | <.001 |
| Mechanical ventilationa | 6/1427 (0.4) | 1/406 (0.2) | 1/242 (0.4) | 2/317 (0.6) | 2/462 (0.4) | .94 |
Abbreviations: ED, emergency department; ICU, intensive care unit; NA, not applicable.
a
Includes invasive or noninvasive.