Comparison of HPLC–log P and c log P data of ethyl and methyl 3,4-diaryl-1-(2-aryl-2-oxoethyl)-1H-pyrazole-5-carboxylates 6a–o and 7a–c.
| Compound | HPLC–log Pa | c log Pb |
|---|---|---|
| Lamellarin O | — | 4.00 |
| Lukianol A | — | 4.57 |
| Lamellarin D | — | 3.79 |
| Lamellarin I | — | 4.17 |
| 6a | 4.381 ± 0.002 | 5.28 |
| 6b | 4.468 ± 0.006 | 5.15 |
| 6c | 4.453 ± 0.005 | 5.44 |
| 6d | 4.711 ± 0.006 | 5.84 |
| 6e | 3.803 ± 0.012 | 4.89 |
| 6f | 4.462 ± 0.005 | 5.02 |
| 6g | 4.531 ± 0.004 | 4.90 |
| 6h | 4.531 ± 0.006 | 5.18 |
| 6i | 4.784 ± 0.005 | 5.58 |
| 6j | 4.490 ± 0.006 | 5.44 |
| 6k | 4.546 ± 0.005 | 5.59 |
| 6l | 4.499 ± 0.006 | 5.31 |
| 6m | 4.545 ± 0.006 | 5.59 |
| 6n | 4.564 ± 0.004 | 5.47 |
| 6o | 4.598 ± 0.004 | 5.75 |
| 7a | 4.279 ± 0.005 | 4.94 |
| 7b | 4.347 ± 0.007 | 4.81 |
| 7c | 4.327 ± 0.007 | 5.10 |
a
Data is provided as a mean value ± standard deviation (SD) of at least three independent experiments.
b
Calculated using ChemDraw 13.0.