In vitro cytotoxicity of synthesized compounds.
| Compound | General structure | R1 | R2 | R3 | R4 | GI50 ± SDa (μM) | ||
|---|---|---|---|---|---|---|---|---|
| HCT116 | HT29 | SW480 | ||||||
| 6a |
|
H | H | H | Et | 5.462 ± 0.393 | >20 | >20 |
| 6b | H | OMe | H | Et | >20 | >20 | >20 | |
| 6c | H | F | H | Et | 1.964 ± 0.266 | 4.979 ± 2.620 | 5.523 ± 3.719 | |
| 6d | H | Cl | H | Et | 14.459 ± 3.915 | >20 | >20 | |
| 6e | H | OH | H | Et | >20 | >20 | >20 | |
| 6f | OMe | H | OMe | Et | 2.293 ± 0.218 | >20 | >20 | |
| 6g | OMe | OMe | OMe | Et | >20 | >20 | >20 | |
| 6h | OMe | F | OMe | Et | 2.072 ± 1.450 | 4.759 ± 2.331 | 4.759 ± 2.331 | |
| 6i | OMe | Cl | OMe | Et | >20 | >20 | >20 | |
| 6j | F | H | H | Et | 3.751 ± 1.056 | 13.757 ± 0.861 | 9.243 ± 2.147 | |
| 6k | F | H | F | Et | 3.386 ± 0.620 | 11.125 ± 2.619 | 7.807 ± 2.017 | |
| 6l | F | H | OMe | Et | 5.051 ± 1.164 | >20 | 8.275 ± 2.339 | |
| 6m | F | F | H | Et | 1.456 ± 0.247 | 2.688 ± 0.110 | 1.441 ± 0.173 | |
| 6n | F | F | OMe | Et | 2.097 ± 0.198 | 6.783 ± 0.463 | 1.641 ± 0.022 | |
| 6o | F | F | F | Et | 2.362 ± 0.039 | 6.666 ± 2.121 | 2.088 ± 0.032 | |
| 7a | H | H | H | Me | >20 | >20 | >20 | |
| 7b | H | OMe | H | Me | >20 | >20 | >20 | |
| 7c | H | F | H | Me | 2.699 ± 0.689 | 9.725 ± 3.711 | >20 | |
a
Data is provided as a mean value ± standard deviation (SD) of at least three independent experiments.