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. Author manuscript; available in PMC: 2023 Mar 10.
Published in final edited form as: Neuron. 2022 Nov 2;110(21):3458–3483. doi: 10.1016/j.neuron.2022.10.020

Figure 5. Microglial states defined by their intrinsic and extrinsic determinants, spatiotemporal context, and layers of complexity.

Figure 5.

Microglial states depend on intrinsic determinants (such as species, ontogeny, sex, or genetic background) as well as the specific context they inhabit, including age, spatial location, and environmental factors (such as nutrition, microbiota, pathogens, drugs, etc.). All together, these factors impinge on microglia at multiple levels (i.e., epigenomic, transcriptomic, proteomic, metabolomics, ultrastructural, and phenomic), which ultimately determine microglial functions. Created with https://BioRender.com