TABLE 2.
Association of lipid biomolecules to fibrosis, and lipid biomolecules according to fibrosis grades in 434 patients with T2DM.
| Biomolecules | Fibrosis E (Kpa) correlation coefficient (p-value) | Without fibrosis N = 398 | With fibrosis N = 36 | p-value |
|---|---|---|---|---|
| Total lipids in lipoprotein particles | 0.010 (0.828) | 9.48 (2.1) | 9.55 (2.5) | 0.853 |
| Total lipids in chylomicrons extremely large VLDL | −0.050 (0.303) | 0.26 (0.3) | 0.22 (0.2) | 0.489 |
| Total lipids in very large VLDL | −0.050 (0.299) | 0.28 (0.2) | 0.26 (0.2) | 0.583 |
| Total lipids in large VLDL | −0.046 (0.335) | 0.45 (0.2) | 0.43 (0.3) | 0.613 |
| Total lipids in medium VLDL | −0.033 (0.496) | 0.68 (0.2) | 0.67 (0.3) | 0.869 |
| Total lipids in small VLDL | 0.016 (0.739) | 0.46 (0.1) | 0.47 (0.1) | 0.530 |
| Total lipids in very small VLDL | 0.135 (0.005) | 0.36 (0.1) | 0.40 (0.1) | 0.011 |
| Total lipids in IDL | 0.069 (0.150) | 1.18 (0.3) | 1.25 (0.3) | 0.212 |
| Total lipids in large LDL | −0.013 (0.790) | 1.73 (0.4) | 1.73 (0.5) | 0.988 |
| Total lipids in medium LDL | −0.052 (0.284) | 0.77 (0.2) | 0.76 (0.2) | 0.602 |
| Total lipids in small LDL | −0.038 (0.433) | 0.35 (0.1) | 0.34 (0.1) | 0.843 |
| Total lipids in HDL | 0.101 (0.036) | 2.96 (0.5) | 3.02 (0.6) | 0.561 |
| Total lipids in very large HDL | 0.278 (<0.001) | 0.11 (0.1) | 0.15 (0.1) | <0.001 |
| Total lipids in large HDL | 0.199 (<0.001) | 0.48 (0.2) | 0.57 (0.3) | 0.027 |
| Total lipids in medium HDL | 0.025 (0.601) | 1.06 (0.2) | 1.04 (0.2) | 0.581 |
| Total lipids in small HDL | −0.109 (0.023) | 1.31 (0.2) | 1.25 (0.1) | 0.024 |
| Total phospholipids in lipoprotein particles | 0.048 (0.320) | 2.95 (0.5) | 2.99 (0.6) | 0.642 |
| Phospholipids in chylomicrons and extremely large VLDL | −0.043 (0.374) | 0.03 (0.01) | 0.03 (0.02) | 0.526 |
| Phospholipids in very large VLDL | −0.038 (0.430) | 0.05 (0.03) | 0.05 (0.04) | 0.737 |
| Phospholipids in large VLDL | −0.042 (0.379) | 0.08 (0.05) | 0.08 (0.05) | 0.678 |
| Phospholipids in medium VLDL | −0.026 (0.590) | 0.14 (0.05) | 0.14 (0.06) | 0.976 |
| Phospholipids in small VLDL | 0.011 (0.820) | 0.10 (0.03) | 0.11 (0.04) | 0.571 |
| Phospholipids in very small VLDL | 0.143 (0.003) | 0.10 (0.02) | 0.11 (0.03) | 0.007 |
| Phospholipids in IDL | 0.067 (0.166) | 0.29 (0.07) | 0.30 (0.08) | 0.228 |
| Phospholipids in large LDL | −0.022 (0.649) | 0.39 (0.08) | 0.38 (0.09) | 0.841 |
| Phospholipids in medium LDL | −0.056 (0.241) | 0.19 (0.04) | 0.18 (0.05) | 0.529 |
| Phospholipids in small LDL | −0.027 (0.576) | 0.10 (0.02) | 0.09 (0.02) | 0.868 |
| Phospholipids in HDL | 0.104 (0.031) | 1.49 (0.3) | 1.52 (0.3) | 0.535 |
| Phospholipids in very large HDL | 0.288 (<0.001) | 0.04 (0.02) | 0.06 (0.03) | <0.001 |
| Phospholipids in large HDL | 0.200 (<0.001) | 0.24 (0.1) | 0.28 (0.1) | 0.027 |
| Phospholipids in medium HDL | 0.026 (0.585) | 0.48 (0.1) | 0.48 (0.1) | 0.612 |
| Phospholipids in small HDL | −0.078 (0.103) | 0.72 (0.1) | 0.69 (0.1) | 0.065 |
| Total cholesterol | 0.017 (0.724) | 5.00 (1.1) | 5.06 (1.2) | 0.755 |
| Cholesterol in chylomicrons and extremely large VLDL | −0.034 (0.483) | 0.06 (0.05) | 0.05 (0.04) | 0.630 |
| Cholesterol in very large VLDL | −0.035 (0.463) | 0.07 (0.04) | 0.07 (0.04) | 0.776 |
| Cholesterol in large VLDL | −0.033 (0.494) | 0.13 (0.07) | 0.13 (0.05) | 0.811 |
| Cholesterol in medium VLDL | −0.005 (0.919) | 0.19 (0.07) | 0.19 (0.08) | 0.791 |
| Cholesterol in small VLDL | 0.030 (0.528) | 0.19 (0.06) | 0.20 (0.07) | 0.339 |
| Cholesterol in very small VLDL | 0.129 (0.007) | 0.19 (0.06) | 0.21 (0.08) | 0.016 |
| Cholesterol in IDL | 0.059 (0.220) | 0.80 (0.2) | 0.84 (0.3) | 0.286 |
| Cholesterol in large LDL | −0.021 (0.667) | 1.24 (0.3) | 1.24 (0.3) | 0.923 |
| Cholesterol in medium LDL | −0.058 (0.230) | 0.55 (0.1) | 0.54 (0.2) | 0.544 |
| Cholesterol in small LDL | −0.046 (0.343) | 0.24 (0.1) | 0.23 (0.1) | 0.702 |
| Cholesterol in HDL | 0.082 (0.089) | 1.34 (0.2) | 1.36 (0.3) | 0.756 |
| Cholesterol in very large HDL | 0.253 (<0.001) | 0.06 (0.02) | 0.08 (0.03) | <0.001 |
| Cholesterol in large HDL | 0.186 (<0.001) | 0.22 (0.1) | 0.26 (0.2) | 0.041 |
| Cholesterol in medium HDL | 0.011 (0.811) | 0.52 (0.1) | 0.51 (0.1) | 0.438 |
| Cholesterol in small HDL | −0.165 (0.001) | 0.54 (0.1) | 0.51 (0.1) | 0.002 |
| Triglycerides | −0.025 (0.597) | 1.52 (0.1) | 1.49 (0.1) | 0.820 |
| Triglycerides in chylomicrons and extremely large VLDL | −0.055 (0.252) | 0.17 (0.2) | 0.14 (0.1) | 0.448 |
| Triglycerides in very large VLDL | −0.058 (0.227) | 0.16 (0.1) | 0.14 (0.1) | 0.484 |
| Triglycerides in large VLDL | −0.053 (0.268) | 0.34 (0.1) | 0.33 (0.2) | 0.515 |
| Triglycerides in medium VLDL | −0.042 (0.383) | 0.34 (0.2) | 0.33 (0.2) | 0.710 |
| Triglycerides in small VLDL | 0.003 (0.945) | 0.17 (0.1) | 0.17 (0.1) | 0.787 |
| Triglycerides in very small VLDL | 0.101 (0.035) | 0.07 (0.02) | 0.07 (0.03) | 0.066 |
| Triglycerides in IDL | 0.134 (0.005) | 0.10 (0.02) | 0.11 (0.03) | 0.018 |
| Triglycerides in large LDL | 0.126 (0.008) | 0.10 (0.02) | 0.11 (0.03) | 0.026 |
| Triglycerides in medium LDL | 0.075 (0.120) | 0.03 (0.01) | 0.04 (0.01) | 0.173 |
| Triglycerides in small LDL | 0.015 (0.754) | 0.02 (0.01) | 0.02 (0.01) | 0.712 |
| Triglycerides in HDL | 0.100 (0.037) | 0.13 (0.04) | 0.14 (0.05) | 0.172 |
| Triglycerides in very large HDL | 0.146 (0.002) | 0.01 (0.002) | 0.07 (0.003) | 0.017 |
| Triglycerides in large HDL | 0.217 (<0.001) | 0.02 (0.01) | 0.03 (0.02) | 0.003 |
| Triglycerides in medium HDL | 0.081 (0.092) | 0.05 (0.02) | 0.05 (0.02) | 0.307 |
| Triglycerides in small HDL | 0.011 (0.816) | 0.05 (0.02) | 0.05 (0.02) | 0.792 |
| Phosphoglycerides | 0.075 (0.120) | 2.57 (0.5) | 2.64 (0.6) | 0.438 |
| Ratio of triglycerides to phosphoglycerides | −0.056 (0.246) | 0.57 (0.2) | 0.54 (0.2) | 0.446 |
| Total cholines | 0.073 (0.128) | 2.86 (0.5) | 2.93 (0.6) | 0.450 |
| Phosphatidylcholines | 0.073 (0.130) | 2.37 (0.5) | 2.43 (0.6) | 0.489 |
| Sphingomyelins | 0.029 (0.545) | 0.52 (0.08) | 0.52 (0.09) | 0.813 |
| Apolipoprotein B | 0.004 (0.929) | 0.95 (0.3) | 0.97 (0.3) | 0.705 |
| Apolipoprotein A1 | 0.091 (0.058) | 1.37 (0.2) | 1.38 (0.3) | 0.698 |
| Ratio of apolipoprotein B to apolipoprotein A1 | −0.042 (0.378) | 0.70 (0.2) | 0.71 (0.2) | 0.839 |
| Total fatty acids | 0.030 (0.533) | 13.60 (2.5) | 13.74 (2.9) | 0.767 |
| Degree of unsaturation | −0.032 (0.511) | 1.30 (0.1) | 1.29 (0.1) | 0.286 |
| Omega-3 fatty acids | 0.029 (0.554) | 0.53 (0.1) | 0.52 (0.1) | 0.842 |
| Omega-6 fatty acids | 0.004 (0.942) | 4.83 (0.7) | 4.79 (0.7) | 0.815 |
| Polyunsaturated fatty acids | 0.009 (0.857) | 5.36 (0.8) | 5.32 (0.8) | 0.806 |
| Monounsaturated fatty acids | 0.036 (0.460) | 3.53 (0.9) | 3.62 (1.0) | 0.582 |
| Saturated fatty acids | 0.039 (0.424) | 4.72 (0.9) | 4.80 (1.2) | 0.642 |
| Linoleic acid | 0.006 (0.894) | 3.73 (0.8) | 3.71 (0.8) | 0.862 |
| Docosahexaenoic acid | 0.037 (0.439) | 0.24 (0.05) | 0.23 (0.05) | 0.384 |
VLDL, very low density lipoprotein; IDL, intermediate density lipoprotein; LDL, low density lipoprotein; HDL, high density lipoprotein.