The pharmacokinetic parameters of DUV in rat plasma after oral administration of 25 mg kg−1.
| Parameter | Unit | Valuea |
|---|---|---|
| Dose (D) | mg kg−1 | 25 |
| Maximum plasma concentration (Cmax) | ng mL−1 | 3804.24 |
| Time required for maximum plasma conc. (Tmax) | h | 1.83 |
| Volume of distribution (Vd) | L kg−1 | 0.88 |
| Elimination rate constant (Kel) | h−1 | 0.97 |
| Elimination half-life time (t1/2) | h−1 | 0.72 |
| Clearance (CL) | L h−1 kg−1 | 0.85 |
| Area under curve from time 0 to last conc. (AUC0–t) | ng h mL−1 | 28 271.33 |
| Area under curve at infinite time (AUC0–∞) | ng h mL−1 | 29 544.19 |
| Area under curve ration (AUC0–t/AUC0–∞) | % | 95.69 |
| Mean residence time (MRT) | h | 1.04 |
a
Values are mean of 5 determinations.