Selected results for the optimal reaction conditionsa.
| ||
|---|---|---|
| Entry | Product | Yieldb (%) |
| 1 |
|
92 |
| 2 |
|
94 |
| 3 |
|
93 |
| 4 |
|
93 |
| 5 |
|
91 |
| 6 |
|
92 |
| 7 |
|
93 |
| 8 |
|
95 |
| 9 |
|
92 |
| 10 |
|
91 |
| 11 |
|
85 |
| 12 |
|
76 |
| 13 |
|
87 |
| 14 |
|
93 |
| 15 |
|
55 |
| 16 |
|
91 |
Reaction conditions: ArGeMe31 (0.65 mmol), aldehyde 2 (0.5 mmol), CoI2 (3.9 mg, 2.5 mol%), tmphen (L8, 3.0 mg, 2.5 mol%), K2CO3 (138 mg, 1.0 mmol), THF (3 mL), 65 °C for 12 h, under air in pressure tubes.
Yields of isolated products after chromatography.