FIG. 2.
Induction of MT mRNA in response to influenza A virus infection is significantly inhibited in the livers but not in the lungs of IL-6 knockout mice. (A) Sequence of immediate upstream promoter of mouse MT-I denoting different regulatory elements. (B) IL-6 null mice (IL-6−/−) and C57BL/6 mice (IL-6+/+) were infected with influenza A virus. The animals were sacrificed after 5 days, and total RNA from the liver and the lung was hybridized to 32P-labeled mouse MT-I minigene (pMT-IΔi) (that detects both isoforms) and GAPDH cDNA.