Table 2.
Plasma proteins that differ significantly by diabetes status and their correlation with plasma gelsolin
| Protein name | Entrez gene symbol | Diabetes t-test p-value |
Effect size | Correlation (r) with pGSN | Correlation p-value |
|---|---|---|---|---|---|
| Anthrax toxin receptor 2 | ANTXR2 | 0.0014 | 1.0142 | 0.6038 | 0.0001 |
| Matrix-remodeling-associated protein 8:Extracellular domain | MXRA8 | 0.0005 | 1.0924 | 0.5692 | 0.0003 |
| Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A | MGAT51 | 0.0007 | 1.0697 | 0.5655 | 0.0003 |
| Cartilage oligomeric matrix protein | COMP | 0.0007 | 1.0689 | 0.5595 | 0.0004 |
| Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A | MGAT52 | 0.0005 | 1.0888 | 0.5144 | 0.0013 |
| Histone-lysine N-methyltransferase EHMT2 | EHMT2 | 0.0013 | 1.0183 | 0.4649 | 0.0043 |
| Transmembrane protein 132C:Extracellular domain | TMEM132C | 0.0003 | 1.1285 | 0.4560 | 0.0052 |
| Adiponectin | ADIPOQ | 0.0001 | 1.2230 | 0.4513 | 0.0057 |
| Brevican core protein | BCAN | 0.0007 | 1.0629 | 0.4334 | 0.0083 |
| Vesicular, overexpressed in cancer, prosurvival protein 1 | VOPP1 | 0.0003 | 1.1278 | 0.4299 | 0.0089 |
| Iduronate 2-sulfatase | IDS | 0.0015 | 1.0072 | 0.4183 | 0.0111 |
| 72 kDa type IV collagenase | MMP2 | 0.0008 | 1.0538 | 0.3861 | 0.0200 |
| Peptidyl-glycine alpha-amidating monooxygenase | PAM | 0.0007 | 1.0729 | 0.3625 | 0.0298 |
| Dihydrolipoyl dehydrogenase, mitochondrial | DLD3 | 0.0000 | 1.2480 | 0.3602 | 0.0309 |
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 | PLCD1 | 0.0017 | 1.0016 | 0.3599 | 0.0311 |
| Prosaposin | PSAP | 0.0013 | 1.0460 | 0.3595 | 0.0313 |
| Neurogenic locus notch homolog protein 3 | NOTCH3 | 0.0008 | 1.0683 | 0.3463 | 0.0386 |
| Acetylcholinesterase | ACHE | 0.0009 | 1.0424 | 0.3347 | 0.0460 |
| Complement C1q tumor necrosis factor-related protein 5 | C1QTNF5 | 0.0015 | 1.0095 | 0.3290 | 0.0501 |
| Calsyntenin-1 | CLSTN1 | 0.0011 | 1.0411 | 0.3266 | 0.0518 |
| Glypican-3 | GPC3 | 0.0016 | 1.0006 | 0.3229 | 0.0548 |
| Protein Wnt-5b | WNT5B | 0.0003 | 1.1235 | 0.3126 | 0.0634 |
| Glutathione reductase, mitochondrial | GSR | 0.0016 | 1.0056 | 0.3006 | 0.0748 |
| Dihydrolipoyl dehydrogenase, mitochondrial | DLD4 | 0.0002 | 1.1495 | 0.2651 | 0.1182 |
| Arylsulfatase A | ARSA | 0.0007 | 1.0896 | 0.2050 | 0.2304 |
| Dermokine | DMKN | 0.0007 | 1.0638 | 0.1446 | 0.4002 |
| Glutathione synthetase | GSS | 0.0008 | 1.0542 | 0.0459 | 0.7905 |
| Cyclic AMP-responsive element-binding protein 3-like protein 4 | CREB3L4 | 0.0007 | 1.0592 | − 0.0158 | 0.9271 |
| Protein phosphatase 1 regulatory subunit 14A | PPP1R14A | 0.0006 | 1.0902 | − 0.0782 | 0.6505 |
| Sulfatase-modifying factor 1 | SUMF1 | 0.0004 | 1.1168 | − 0.0941 | 0.5853 |
| Ribonuclease 4 | RNASE4 | 0.0001 | 1.1939 | − 0.0970 | 0.5735 |
| SH2 domain-containing protein 1A | SH2D1A | 0.0007 | 1.0685 | − 0.1072 | 0.5336 |
| Cyclin-dependent kinase 15; EC = 2.7.11.22 | CDK15 | 0.0009 | 1.0487 | − 0.1344 | 0.4345 |
| Apoptosis-associated speck-like protein containing a CARD | PYCARD | 0.0007 | 1.0588 | − 0.1366 | 0.4270 |
| Protocadherin gamma-C3 | PCDHGC3 | 0.0011 | 1.0315 | − 0.1539 | 0.3702 |
| Trafficking protein particle complex subunit 3 | TRAPPC3 | 0.0013 | 1.0145 | − 0.1561 | 0.3631 |
| Ephrin-A1 | EFNA1 | 0.0010 | 1.0422 | − 0.1580 | 0.3575 |
| Neural proliferation differentiation and control protein 1 | NPDC1 | 0.0007 | 1.0657 | − 0.1769 | 0.3019 |
| Delta-like protein 1 | DLL1 | 0.0001 | 1.1820 | − 0.1792 | 0.2956 |
| Guanine nucleotide exchange factor VAV3 | VAV3 | 0.0004 | 1.1155 | − 0.2064 | 0.2272 |
| Protein FAM3B | FAM3B | 0.0010 | 1.0383 | − 0.2271 | 0.1828 |
| Vascular non-inflammatory molecule 2 | VNN2 | 0.0006 | 1.0792 | − 0.2457 | 0.1485 |
| Calsequestrin-1 | CASQ1 | 0.0011 | 1.0292 | − 0.2478 | 0.1450 |
| Protein kinase C gamma type | PRKCG | 0.0002 | 1.1413 | − 0.2723 | 0.1082 |
| Plasma serine protease inhibitor | SERPINA5 | 0.0014 | 1.0203 | − 0.2972 | 0.0783 |
| Rho GTPase-activating protein 36 | ARHGAP36 | 0.0000 | 1.2910 | − 0.3037 | 0.0718 |
| Insulin-like peptide INSL6 | INSL6 | 0.0001 | 1.1802 | − 0.3769 | 0.0234 |
SomaScan was used to quantify plasma proteins and a Student’s t-test was used to examine differences between euglycemic and diabetic individuals. Cohen effect size is indicated. Pearson’s correlation (r) and p-value are indicated for the relationships between plasma proteins and pGSN. Proteins significantly correlated with pGSN are indicated in bold. Values are sorted by correlation with high positive values at top
Multiple markers can match to the same target protein and are uniquely identified by sequence numbers. 1. SomaScan seq. 21768.9; . 2. SomaScan seq. 21813.171; 3. SomaScan seq. 10025.1 ; 4. SomaScan seq. 15527.90