Table 1.

PICOS criteria for inclusion and exclusion of studies

Parameter	Inclusion criteria	Exclusion criteria
Population	Healthy adults	Populations with comorbidities or dietary restrictions (ie, vegan/vegetarians)
Intervention	Creatine monohydrate supplementation	Other additional nutritional interventions
Comparator	Placebo	Non-placebo control
Outcomes	Memory performance outcomes	Other outcomes related to cognitive function
Study design	Randomized controlled trials	Non-randomized controlled trials, cohort studies, in vivo studies, in vitro studies