ID,SMILES,DCAF1 KD (nM)
3a,O=C(N[C@@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,NB
3b,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,16400; 16900
3c,O=C(N[C@@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3F,13500 ± 200
3d,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3F,490 ± 90
5a,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CN(C)N=C2C3=CC=CC=C3,10000; 9900
5b,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=C(C3=CC=CC=C3)N(C)N=C2,>50000
5c,O=C(N[C@H](C1=CC=CC=C1)CC(NC)=O)C2=CNN=C2C3=CC=CC=C3,NB
5d,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC#N)C2=CNN=C2C3=CC=CC=C3F,2890; 2910
14a,O=C(NCCC(N)=O)C1=CNN=C1C2=CC=CC=C2,NB
14b,O=C(N[C@H](C1=CC=CC=C1Cl)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,22960; 21940
14c,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,4220; 4000
14d,O=C(N[C@H](C1=CC=C(Cl)C=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,6900; 6800
14e,O=C(N[C@H](C1=CC=CC=C1F)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,15500; 15800
14f,O=C(N[C@H](C1=CC=CC(F)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,NB
14g,O=C(N[C@H](C1=CC=C(F)C=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,9600; 9800
14h,O=C(N[C@H](C1=CC=CC=C1OC)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,NB
14i,O=C(N[C@H](C1=CC=CC(OC)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,NB
14j,O=C(N[C@H](C1=CC=C(OC)C=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3,NB
15a,CC1=NNC=C1C(N[C@H](C2=CC=CC=C2)CC(N)=O)=O,NB
15b,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3Cl,4000; 4100
15c,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC(Cl)=C3,11100; 11200
15d,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=C(Cl)C=C3,2890; 2890
15e,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3F,3400; 3420
15f,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC(F)=C3,15700; 15700
15g,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=C(F)C=C3,13280; 12960
15h,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=C(OC)C=C3,35100; 34700
15i,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=CC(C#N)=C3,24900; 26500
15j,O=C(N[C@H](C1=CC=CC=C1)CC(N)=O)C2=CNN=C2C3=CC=C(F)C(Cl)=C3,15900; 15800
26a,O=C(N[C@H](C1=CC=C(F)C(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3F,170; 180
26b,O=C(N[C@H](C1=CC=C(Cl)C(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=CC=C3F,200; 217
26c,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=C(F)C=C3F,265; 282
26d,O=C(N[C@H](C1=CC=CC(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=C(Cl)C=C3F,85 ± 10
26e,O=C(N[C@H](C1=CC=C(F)C(Cl)=C1)CC(N)=O)C2=CNN=C2C3=CC=C(Cl)C=C3F,38 ± 1.5