gene_cluster,KO,KEGG Definition,eggNOG Prefered Name,eggNOG KEGG_ko,COG Category,eggNOG Description
GC_00001185,K01159,crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4],ruvC,ko:K01159,L,Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GC_00000022,K03701,excinuclease ABC subunit A,uvrA,ko:K03701,L,"The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate"
GC_00000244,K02372,3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59],fabZ,"ko:K02372,ko:K16363",I,Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
GC_00000245,K04042,bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157],glmU,"ko:K04042,ko:K11528,ko:K16203",M,"Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain"
GC_00028363,NA,NA,,ko:K01992,S,transport system permease component
GC_00001116,K03685,ribonuclease III [EC:3.1.26.3],,,,
GC_00001371,K06015,N-acyl-D-amino-acid deacylase [EC:3.5.1.81],,ko:K06015,Q,N-Acyl-D-aspartate D-glutamate deacylase
GC_00000711,NA,NA,yaaT,,S,PSP1 C-terminal conserved region
GC_00000437,K00616,transaldolase [EC:2.2.1.2],,,,
GC_00000650,NA,NA,,,M,ORF6N domain
GC_00000163,K02967,small subunit ribosomal protein S2,rpsB,ko:K02967,J,Belongs to the universal ribosomal protein uS2 family
GC_00000162,K02600,transcription termination/antitermination protein NusA,,,,
GC_00000304,K01658,anthranilate synthase component II [EC:4.1.3.27],trpG,"ko:K01658,ko:K01664,ko:K13497",EH,Peptidase C26
GC_00000397,K03564,thioredoxin-dependent peroxiredoxin [EC:1.11.1.24],bcp,ko:K03564,O,Redoxin
GC_00005350,K09765,epoxyqueuosine reductase [EC:1.17.99.6],queH,"ko:K03470,ko:K09765",C,"Uncharacterized BCR, COG1636"
GC_00000835,K03469,ribonuclease HI [EC:3.1.26.4],rnhA,ko:K03469,L,Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GC_00000441,K15778,phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2],algC,"ko:K01835,ko:K01840,ko:K15778",G,"Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III"
GC_00001021,K02456,general secretion pathway protein G,gspG,"ko:K02246,ko:K02456,ko:K02458",U,general secretion pathway protein G
GC_00018198,K04069,pyruvate formate lyase activating enzyme [EC:1.97.1.4],pflA,ko:K04069,C,PFAM Radical SAM domain protein
GC_00000114,K01139,"GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]",relA,ko:K00951,KT,In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GC_00000115,K01689,enolase [EC:4.2.1.11],eno,ko:K01689,G,Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
GC_00001781,K00333,NADH-quinone oxidoreductase subunit D [EC:7.1.1.2],nuoD,"ko:K00333,ko:K13378",C,"NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient"
GC_00000186,K00554,tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228],trmD,"ko:K00554,ko:K01770",J,Belongs to the RNA methyltransferase TrmD family
GC_00000187,K00954,pantetheine-phosphate adenylyltransferase [EC:2.7.7.3],coaD,ko:K00954,H,"Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate"
GC_00000593,K09808,lipoprotein-releasing system permease protein,lolC,"ko:K02004,ko:K09808",M,MacB-like periplasmic core domain
GC_00001068,K04066,primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-],,,,
GC_00000409,K01649,2-isopropylmalate synthase [EC:2.3.3.13],cimA,ko:K01649,E,Belongs to the alpha-IPM synthase homocitrate synthase family
GC_00001836,K00784,ribonuclease Z [EC:3.1.26.11],,,T,Beta-lactamase superfamily domain
GC_00000233,K02895,large subunit ribosomal protein L24,rplX,ko:K02895,J,One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GC_00000055,K00341,NADH-quinone oxidoreductase subunit L [EC:7.1.1.2],nuoL,ko:K00341,CP,NADH-quinone oxidoreductase
GC_00000054,K03270,3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45],hldE,ko:K03272,H,"Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose"
GC_00000767,K12410,NAD-dependent deacetylase [EC:2.3.1.286],cobB,ko:K12410,K,Belongs to the sirtuin family. Class
GC_00000990,K02455,general secretion pathway protein F,,,,
GC_00001666,NA,NA,,,S,Domain of unknown function (DUF1844)
GC_00000207,K02996,small subunit ribosomal protein S9,rpsI,ko:K02996,J,Belongs to the universal ribosomal protein uS9 family
GC_00000061,K21029,molybdopterin-synthase adenylyltransferase [EC:2.7.7.80],moeB,ko:K21029,H,ThiF family
GC_00000060,K07636,"two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]",phoR,"ko:K02484,ko:K07636,ko:K07768",T,His Kinase A (phosphoacceptor) domain
GC_00000206,K00790,UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7],murA,ko:K00790,M,Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GC_00000535,K23264,phosphoribosylformylglycinamidine synthase subunit PurS [EC:6.3.5.3],,,,
GC_00000753,K01512,acylphosphatase [EC:3.6.1.7],acyP,ko:K01512,C,Acylphosphatase
GC_00007693,NA,NA,glmM,ko:K03431,G,phosphoglucosamine mutase activity
GC_00031431,K07131,uncharacterized protein,,,,
GC_00000936,K00615,transketolase [EC:2.2.1.1],tktB,ko:K00615,G,"Transketolase, pyrimidine binding domain"
GC_00000169,K02986,small subunit ribosomal protein S4,rpsD,ko:K02986,J,"One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit"
GC_00000168,K01951,GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2],guaA,"ko:K01951,ko:K03790",F,Catalyzes the synthesis of GMP from XMP
GC_00010108,K00384,thioredoxin reductase (NADPH) [EC:1.8.1.9],trxB,ko:K00384,C,Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
GC_00000295,K01895,acetyl-CoA synthetase [EC:6.2.1.1],acsA,ko:K01895,I,"Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA"
GC_00014689,K15022,formate dehydrogenase (NADP+) beta subunit [EC:1.17.1.10],sfrB,"ko:K00335,ko:K15022",E,FAD-dependent pyridine nucleotide-disulphide oxidoreductase
GC_00030019,NA,NA,,,K,sequence-specific DNA binding
GC_00000028,K03798,cell division protease FtsH [EC:3.4.24.-],ftsH,ko:K03798,O,"Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins"
GC_00000029,K02004,putative ABC transport system permease protein,salY,"ko:K02004,ko:K05685",V,MacB-like periplasmic core domain
GC_00000680,K00425,cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7],,,,
GC_00002786,K18855,UDP-N-acetylglucosamine 3-dehydrogenase [EC:1.1.1.374],,,,
GC_00021045,K01520,dUTP pyrophosphatase [EC:3.6.1.23],dut,"ko:K01520,ko:K13038",F,"This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA"
GC_00026184,K08483,phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9],ptsI,ko:K08483,G,General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GC_00000475,K00791,tRNA dimethylallyltransferase [EC:2.5.1.75],miaA,ko:K00791,J,"Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)"
GC_00005380,K02523,octaprenyl-diphosphate synthase [EC:2.5.1.90],ispB,"ko:K00805,ko:K02523",H,isoprenoid biosynthetic process
GC_00000120,K06942,ribosome-binding ATPase,ychF,ko:K06942,J,ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
GC_00000346,K01963,acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15],accD,ko:K01963,I,Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GC_00003089,K08281,nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-],pncA,"ko:K08281,ko:K12132",Q,Isochorismatase family
GC_00000121,K01873,valyl-tRNA synthetase [EC:6.1.1.9],valS,ko:K01873,J,"amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner"
GC_00000789,K04652,hydrogenase nickel incorporation protein HypB,hypB,ko:K04652,KO,"CobW/HypB/UreG, nucleotide-binding domain"
GC_00001727,K16149,"1,4-alpha-glucan branching enzyme [EC:2.4.1.18]",,"ko:K03406,ko:K16149",G,Belongs to the glycosyl hydrolase 57 family
GC_00034735,NA,NA,,"ko:K02481,ko:K07714",T,PFAM sigma-54 factor interaction domain-containing protein
GC_00000238,K00602,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10],purH,ko:K00602,F,Bifunctional purine biosynthesis protein PurH
GC_00000801,NA,NA,,,C,Protein conserved in bacteria
GC_00009549,NA,NA,,,S,inositol 2-dehydrogenase activity
GC_00000490,K00858,NAD+ kinase [EC:2.7.1.23],nadK,ko:K00858,G,"Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP"
GC_00001205,K09141,uncharacterized protein,amrA,"ko:K06990,ko:K09141",S,ferrous iron binding
GC_00001062,K01923,phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6],purC,"ko:K01587,ko:K01756,ko:K01923",F,SAICAR synthetase
GC_00001204,K02003,putative ABC transport system ATP-binding protein,,ko:K02003,V,ABC transporter
GC_00000403,K00928,aspartate kinase [EC:2.7.2.4],,,,
GC_00000665,K01790,"dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]",rfbC,ko:K01790,M,"Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose"
GC_00000402,K03101,signal peptidase II [EC:3.4.23.36],lspA,ko:K03101,MU,This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GC_00000157,K01265,methionyl aminopeptidase [EC:3.4.11.18],map,ko:K01265,J,Metallopeptidase family M24
GC_00000156,K18189,translational activator of cytochrome c oxidase 1,yebC,,K,Transcriptional regulator
GC_00000598,K00833,adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62],bioA,"ko:K00833,ko:K19563",H,"Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor"
GC_00000849,K01704,3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35],leuD,"ko:K00052,ko:K01704,ko:K20453",E,"Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate"
GC_00003570,K07031,D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168],,"ko:K00869,ko:K07031",G,GHMP kinase
GC_00000016,K04771,serine protease Do [EC:3.4.21.107],htrA,ko:K04771,O,Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
GC_00002111,K01810,glucose-6-phosphate isomerase [EC:5.3.1.9],pgi,ko:K01810,G,Phosphoglucose isomerase
GC_00030573,K07095,uncharacterized protein,,ko:K07095,S,"retrograde transport, endosome to Golgi"
GC_00002110,K04085,tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-],,ko:K04085,O,Belongs to the sulfur carrier protein TusA family
GC_00000271,K02961,small subunit ribosomal protein S17,rpsQ,ko:K02961,J,"One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA"
GC_00000017,K03696,ATP-dependent Clp protease ATP-binding subunit ClpC,clpB,"ko:K03694,ko:K03695",O,"Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE"
GC_00001718,NA,NA,apaH,,T,Calcineurin-like phosphoesterase superfamily domain
GC_00000941,K07168,CBS domain-containing membrane protein,nth,ko:K10773,L,Protein of unknown function (DUF2400)
GC_00000378,K01586,diaminopimelate decarboxylase [EC:4.1.1.20],,,,
GC_00000379,K06178,23S rRNA pseudouridine2605 synthase [EC:5.4.99.22],rluB,"ko:K06178,ko:K06182,ko:K06183",J,Belongs to the pseudouridine synthase RsuA family
GC_00000084,K02337,DNA polymerase III subunit alpha [EC:2.7.7.7],dnaE,ko:K02337,L,DNA-directed DNA polymerase
GC_00000085,K06997,PLP dependent protein,yggS,ko:K06997,S,"Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis"
GC_00000380,K12984,"(heptosyl)LPS beta-1,4-glucosyltransferase [EC:2.4.1.-]",kdtX,ko:K12984,M,biosynthesis glycosyltransferase
GC_00005121,K00950,2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3],dapL,ko:K10206,E,Aminotransferase
GC_00000381,K03590,cell division protein FtsA,ftsA,ko:K03590,D,Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
GC_00000529,K03455,"monovalent cation:H+ antiporter-2, CPA2 family",kefB,ko:K03455,P,Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
GC_00023184,K19221,cob(I)alamin adenosyltransferase [EC:2.5.1.17],cobO,ko:K19221,H,PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP
GC_00031179,K06039,uncharacterized protein involved in oxidation of intracellular sulfur,,ko:K06039,P,PFAM DsrE family protein
GC_00002924,K19793,(5-formylfuran-3-yl)methyl phosphate transaminase [EC:2.6.1.108],aspB,,E,PFAM Aminotransferase class I and II
GC_00000288,K00645,[acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39],fabD,ko:K00645,I,malonyl CoA-acyl carrier protein transacylase
GC_00001041,K22227,AdoMet-dependent heme synthase [EC:1.3.98.6],pqqE,ko:K22227,C,PFAM Radical SAM domain protein
GC_00000289,K01878,glycyl-tRNA synthetase alpha chain [EC:6.1.1.14],glyQ,"ko:K01878,ko:K14164",J,Glycyl-tRNA synthetase alpha subunit
GC_00000420,K23269,phosphoribosylformylglycinamidine synthase subunit PurL [EC:6.3.5.3],purL,ko:K01952,F,Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GC_00000312,K00945,CMP/dCMP kinase [EC:2.7.4.25],cmk,"ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799",F,Belongs to the cytidylate kinase family. Type 1 subfamily
GC_00000174,K02078,acyl carrier protein,acpP,ko:K02078,IQ,Carrier of the growing fatty acid chain in fatty acid biosynthesis
GC_00000175,K02931,large subunit ribosomal protein L5,rplE,ko:K02931,J,"This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits"
GC_00000313,K01770,"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]",ispF,"ko:K00554,ko:K00991,ko:K01770,ko:K12506",I,"Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)"
GC_00000035,K04043,molecular chaperone DnaK,dnaK,ko:K04043,O,Heat shock 70 kDa protein
GC_00000253,K21929,uracil-DNA glycosylase [EC:3.2.2.27],dpo,ko:K21929,L,Uracil DNA glycosylase superfamily
GC_00000252,K00764,amidophosphoribosyltransferase [EC:2.4.2.14],,,,
GC_00000561,K03179,4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39],ubiA,ko:K03179,H,UbiA prenyltransferase family
GC_00000706,K04070,putative pyruvate formate lyase activating enzyme [EC:1.97.1.4],PflX,ko:K04070,C,radical SAM domain protein
GC_00000469,K00215,4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8],dapB,"ko:K00215,ko:K03546",E,Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
GC_00025699,K13626,flagellar assembly factor FliW,fliW,ko:K13626,S,"Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum"
GC_00000468,K02401,flagellar biosynthesis protein FlhB,,,,
GC_00010593,NA,NA,rpfG,,T,"PFAM metal-dependent phosphohydrolase, HD sub domain"
GC_00001008,K01624,"fructose-bisphosphate aldolase, class II [EC:4.1.2.13]",,ko:K01624,G,Fructose-bisphosphate aldolase class-II
GC_00000224,K11752,diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193],ribD,"ko:K01498,ko:K11752",H,"Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate"
GC_00000043,K13195,cold-inducible RNA-binding protein,,,,
GC_00000225,K01409,N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234],tsaD,"ko:K01409,ko:K03070",J,"Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction"
GC_00000516,K18285,aminodeoxyfutalosine synthase [EC:2.5.1.120],mqnE,"ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285",H,"Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate"
GC_00000770,K24012,acetate---CoA ligase (ADP-forming) [EC:6.2.1.13],,"ko:K01905,ko:K09181,ko:K22224",C,ATP-grasp domain
GC_00000517,K00286,pyrroline-5-carboxylate reductase [EC:1.5.1.2],proC,ko:K00286,E,Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GC_00023021,NA,NA,,ko:K02843,M,Glycosyltransferase family 9 (heptosyltransferase)
GC_00000584,K04773,protease IV [EC:3.4.21.-],sppA,ko:K04773,OU,Peptidase family S49
GC_00000585,K05515,penicillin-binding protein 2 [EC:3.4.16.4],mrdA,ko:K05515,M,Penicillin-binding Protein dimerisation domain
GC_00000191,K02357,elongation factor Ts,tsf,ko:K02357,J,Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GC_00000190,K02434,aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7],gatB,"ko:K01876,ko:K02434",J,Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GC_00000855,K02563,UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227],murG,ko:K02563,M,Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GC_00007995,K02035,peptide/nickel transport system substrate-binding protein,appA,ko:K02035,E,"Bacterial extracellular solute-binding proteins, family 5 Middle"
GC_00027733,K00311,electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1],etf,ko:K00311,C,"Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S"
GC_00000099,K03856,3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54],aroF,ko:K03856,E,NeuB family
GC_00000098,K01939,adenylosuccinate synthase [EC:6.3.4.4],purA,ko:K01939,F,Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GC_00000631,K02412,flagellum-specific ATP synthase [EC:7.4.2.8],fliI,"ko:K02412,ko:K03224",NU,"ATP synthase alpha/beta family, beta-barrel domain"
GC_00000457,K04518,prephenate dehydratase [EC:4.2.1.51],pheA,"ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187",E,Chorismate mutase type II
GC_00028243,K03407,"two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]",cheA,"ko:K02487,ko:K03407,ko:K06596",T,"Signal transducing histidine kinase, homodimeric domain"
GC_00000364,K00942,guanylate kinase [EC:2.7.4.8],gmk,"ko:K00942,ko:K01591",F,"Essential for recycling GMP and indirectly, cGMP"
GC_00000102,K01869,leucyl-tRNA synthetase [EC:6.1.1.4],leuS,ko:K01869,J,Belongs to the class-I aminoacyl-tRNA synthetase family
GC_00000463,K00930,acetylglutamate kinase [EC:2.7.2.8],argB,ko:K00930,E,Belongs to the acetylglutamate kinase family. ArgB subfamily
GC_00000462,K01653,acetolactate synthase I/III small subunit [EC:2.2.1.6],ilvH,ko:K01653,E,ACT domain
GC_00000604,K02346,DNA polymerase IV [EC:2.7.7.7],dinB,ko:K02346,L,"Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII"
GC_00000969,K02488,"two-component system, cell cycle response regulator [EC:2.7.7.65]",,,T,cheY-homologous receiver domain
GC_00001556,K01607,4-carboxymuconolactone decarboxylase [EC:4.1.1.44],yurZ,"ko:K00627,ko:K01607",S,peroxiredoxin activity
GC_00000137,K06888,uncharacterized protein,yyaL,ko:K06888,O,"Protein of unknown function, DUF255"
GC_00000136,K11749,regulator of sigma E protease [EC:3.4.24.-],rseP,ko:K11749,M,Peptidase family M50
GC_00010491,K02488,"two-component system, cell cycle response regulator [EC:2.7.7.65]",,,T,PFAM GGDEF domain containing protein
GC_00021669,K02488,"two-component system, cell cycle response regulator [EC:2.7.7.65]",,,T,diguanylate cyclase
GC_00000860,NA,NA,usp1,ko:K22405,C,Rubrerythrin
GC_00000259,K02888,large subunit ribosomal protein L21,rplU,ko:K02888,J,This protein binds to 23S rRNA in the presence of protein L20
GC_00001090,K06287,septum formation protein,maf,"ko:K00014,ko:K03215,ko:K06287",D,Maf-like protein
GC_00000318,K02909,large subunit ribosomal protein L31,rpmE,ko:K02909,J,Binds the 23S rRNA
GC_00000319,K05788,integration host factor subunit beta,ihfB,ko:K05788,L,bacterial (prokaryotic) histone like domain
GC_00000921,K05808,putative sigma-54 modulation protein,raiA,"ko:K03733,ko:K05808,ko:K05809",J,Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GC_00000282,K01892,histidyl-tRNA synthetase [EC:6.1.1.21],hisS,ko:K01892,J,Histidyl-tRNA synthetase
GC_00000283,K01867,tryptophanyl-tRNA synthetase [EC:6.1.1.2],trpS,ko:K01867,J,tRNA synthetases class I (W and Y)
GC_00001485,K09015,Fe-S cluster assembly protein SufD,sufD,"ko:K07033,ko:K09015",O,Uncharacterized protein family (UPF0051)
GC_00000210,K02945,small subunit ribosomal protein S1,rpsA,"ko:K02945,ko:K03527,ko:K07571",J,thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
GC_00000076,K13993,HSP20 family protein,hspA-1,ko:K13993,O,Belongs to the small heat shock protein (HSP20) family
GC_00000077,K03671,thioredoxin 1,trxA,ko:K03671,O,Belongs to the thioredoxin family
GC_00000211,K02933,large subunit ribosomal protein L6,rplF,ko:K02933,J,"This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center"
GC_00001416,K02194,heme exporter protein B,,,,
GC_00001324,K01733,threonine synthase [EC:4.2.3.1],thrC,ko:K01733,E,Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GC_00003222,K03438,16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199],rsmH,ko:K03438,J,Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
GC_00000744,K02417,flagellar motor switch protein FliN,fliN,ko:K02417,N,Type III flagellar switch regulator (C-ring) FliN C-term
GC_00000745,K00104,glycolate oxidase [EC:1.1.3.15],larD,ko:K00104,C,"FAD linked oxidases, C-terminal domain"
GC_00000523,K11927,ATP-dependent RNA helicase RhlE [EC:3.6.4.13],,,,
GC_00000109,K06217,phosphate starvation-inducible protein PhoH and related proteins,phoH,ko:K06217,T,PhoH-like protein
GC_00000108,K01870,isoleucyl-tRNA synthetase [EC:6.1.1.5],,,,
GC_00000093,K02335,DNA polymerase I [EC:2.7.7.7],polA,ko:K02335,L,"In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity"
GC_00005055,K00820,glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16],,ko:K00820,M,glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GC_00000092,K02519,translation initiation factor IF-2,infB,ko:K02519,J,One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GC_00006754,K23144,UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.7.7.24 2.7.7.83 2.3.1.157 2.3.1.276],rffH,"ko:K00973,ko:K04042,ko:K16881",JM,"COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon"
GC_00000001,K02481,"two-component system, NtrC family, response regulator",,,T,"Bacterial regulatory protein, Fis family"
GC_00000267,K01426,amidase [EC:3.5.1.4],,,,
GC_00000326,K07192,flotillin,qmcA,,O,prohibitin homologues
GC_00032523,K08591,acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275],plsY,ko:K08591,I,acyl-phosphate glycerol-3-phosphate acyltransferase activity
GC_00000141,K03553,recombination protein RecA,recA,ko:K03553,L,"Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage"
GC_00000327,K15987,K(+)-stimulated pyrophosphate-energized sodium pump,hppA,ko:K15987,C,Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force
GC_00000486,K04764,integration host factor subunit alpha,himA,"ko:K04764,ko:K05788",L,bacterial (prokaryotic) histone like domain
GC_00001280,K00395,"adenylylsulfate reductase, subunit B [EC:1.8.99.2]",aprB,ko:K00395,C,Adenosine-5'-phosphosulfate reductase beta subunit
GC_00000048,K01657,anthranilate synthase component I [EC:4.1.3.27],trpE,ko:K01657,EH,"Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia"
GC_00003386,NA,NA,,,E,PFAM transglutaminase domain protein
GC_00000426,K00058,D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399],,,,
GC_00000173,K02836,peptide chain release factor 2,prfB,ko:K02836,J,Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GC_00000315,K06041,arabinose-5-phosphate isomerase [EC:5.3.1.13],kdsD,"ko:K01627,ko:K03281,ko:K06041",M,Belongs to the SIS family. GutQ KpsF subfamily
GC_00000314,K05837,rod shape determining protein RodA,mrdB,ko:K05837,D,Peptidoglycan polymerase that is essential for cell wall elongation
GC_00001513,K01678,fumarate hydratase subunit beta [EC:4.2.1.2],fumB,"ko:K01676,ko:K01678,ko:K03780",C,Fumarase C-terminus
GC_00001512,K01677,fumarate hydratase subunit alpha [EC:4.2.1.2],ttdA,ko:K01677,C,Fumarate hydratase (Fumerase)
GC_00000386,K03980,putative peptidoglycan lipid II flippase,murJ,ko:K03980,S,Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
GC_00026323,NA,NA,ctaD,ko:K02274,C,Belongs to the heme-copper respiratory oxidase family
GC_00000824,K03722,ATP-dependent DNA helicase DinG [EC:3.6.4.12],dinG,ko:K03722,L,HELICc2
GC_00000964,K00570,phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71],pmtA,ko:K00570,Q,methyltransferase
GC_00000792,K00762,orotate phosphoribosyltransferase [EC:2.4.2.10],pyrE,ko:K00762,F,"Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)"
GC_00000793,K17103,CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8],,,,
GC_00027799,K03620,Ni/Fe-hydrogenase 1 B-type cytochrome subunit,,ko:K03620,C,"Ni Fe-hydrogenase, b-type cytochrome subunit"
GC_00000609,K24105,mutual gliding-motility protein MglA,mglA,ko:K06883,S,ADP-ribosylation factor family
GC_00000032,K01961,"acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]",,,,
GC_00000033,K01533,P-type Cu2+ transporter [EC:7.2.2.9],,,,
GC_00025960,K02636,cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6],,"ko:K02636,ko:K03886",C,Rieske [2Fe-2S] domain
GC_00000582,K00768,nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21],cobT,ko:K00768,H,"Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)"
GC_00000419,K00821,acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17],argD,ko:K00821,E,Aminotransferase class-III
GC_00000418,K01733,threonine synthase [EC:4.2.3.1],thrC1,ko:K01733,E,Pyridoxal-phosphate dependent enzyme
GC_00005010,K00809,deoxyhypusine synthase [EC:2.5.1.46],,ko:K00809,O,Belongs to the deoxyhypusine synthase family
GC_00000045,K00330,NADH-quinone oxidoreductase subunit A [EC:7.1.1.2],,,,
GC_00000223,K01875,seryl-tRNA synthetase [EC:6.1.1.11],serS,ko:K01875,J,"Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)"
GC_00000222,K01696,tryptophan synthase beta chain [EC:4.2.1.20],trpB,ko:K01696,E,The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GC_00000044,K01883,cysteinyl-tRNA synthetase [EC:6.1.1.16],cysS,"ko:K01883,ko:K15526",J,Belongs to the class-I aminoacyl-tRNA synthetase family
GC_00006618,NA,NA,mtnP,ko:K00772,F,purine-nucleoside phosphorylase activity
GC_00000511,NA,NA,,,C,Cytochrome c
GC_00000510,K00703,starch synthase [EC:2.4.1.21],glgA,ko:K00703,G,"Synthesizes alpha-1,4-glucan chains using ADP-glucose"
GC_00013664,K00763,nicotinate phosphoribosyltransferase [EC:6.3.4.21],pncB,ko:K00763,H,Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GC_00000636,K11753,riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2],ribF,"ko:K07011,ko:K11753",H,Riboflavin kinase
GC_00000637,K01735,3-dehydroquinate synthase [EC:4.2.3.4],aroB,"ko:K01735,ko:K13829",E,Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GC_00000451,K07082,UPF0755 protein,mltG,ko:K07082,S,Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GC_00000362,K14441,ribosomal protein S12 methylthiotransferase [EC:2.8.4.4],rimO,ko:K14441,J,Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
GC_00000104,K01872,alanyl-tRNA synthetase [EC:6.1.1.7],alaS,ko:K01872,J,Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GC_00000105,K00343,NADH-quinone oxidoreductase subunit N [EC:7.1.1.2],nuoN,ko:K00343,C,"NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient"
GC_00000196,K02982,small subunit ribosomal protein S3,rpsC,ko:K02982,J,"Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation"
GC_00000197,K02878,large subunit ribosomal protein L16,rplP,ko:K02878,J,Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GC_00000559,K00052,3-isopropylmalate dehydrogenase [EC:1.1.1.85],leuB,ko:K00052,CE,Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
GC_00000853,K02834,ribosome-binding factor A,rbfA,ko:K02834,J,One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GC_00000038,K09117,uncharacterized protein,,ko:K09117,T,Yqey-like protein
GC_00003191,K00943,dTMP kinase [EC:2.7.4.9],tmk,ko:K00943,F,Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GC_00000039,K00331,NADH-quinone oxidoreductase subunit B [EC:7.1.1.2],nuoB,ko:K00331,C,"NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient"
GC_00005299,NA,NA,,,M,Polymer-forming cytoskeletal
GC_00000464,K03601,exodeoxyribonuclease VII large subunit [EC:3.1.11.6],xseA,"ko:K03601,ko:K03797",L,"Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides"
GC_00000603,K03118,sec-independent protein translocase protein TatC,tatC,ko:K03118,U,Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GC_00000465,K09710,ribosome-associated protein,rsfS,"ko:K00969,ko:K09710",J,"Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation"
GC_00000798,K06281,hydrogenase large subunit [EC:1.12.99.6],hyaL,ko:K06281,C,Belongs to the NiFe NiFeSe hydrogenase large subunit family
GC_00006491,K07277,outer membrane protein insertion porin family,bamA,ko:K07277,M,membrane organization
GC_00000356,K07403,membrane-bound serine protease (ClpP class),,,,
GC_00000130,K02343,DNA polymerase III subunit gamma/tau [EC:2.7.7.7],dnaX,ko:K02343,L,"DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity"
GC_00000071,K02470,DNA gyrase subunit B [EC:5.6.2.2],gyrB,ko:K02470,L,"A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner"
GC_00000217,K02876,large subunit ribosomal protein L15,rplO,ko:K02876,J,binds to the 23S rRNA
GC_00000216,K03631,DNA repair protein RecN (Recombination protein N),recN,"ko:K03631,ko:K13582",L,May be involved in recombinational repair of damaged DNA
GC_00000070,K04078,chaperonin GroES,,,,
GC_00029537,K02793,mannose PTS system EIIA component [EC:2.7.1.191],manX,"ko:K02793,ko:K02794,ko:K02821",G,PTS system fructose IIA component
GC_00001144,K06167,"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55]",,,,
GC_00000743,K01726,gamma-carbonic anhydrase [EC:4.2.1.-],yrdA,,S,Bacterial transferase hexapeptide (six repeats)
GC_00000524,K01613,phosphatidylserine decarboxylase [EC:4.1.1.65],psd,ko:K01613,I,Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
GC_00000742,K01776,glutamate racemase [EC:5.1.1.3],murI,ko:K01776,M,Provides the (R)-glutamate required for cell wall biosynthesis
GC_00000179,K02887,large subunit ribosomal protein L20,rplT,ko:K02887,J,Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GC_00000178,K03650,tRNA modification GTPase [EC:3.6.-.-],mnmE,ko:K03650,S,"Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34"
GC_00000926,NA,NA,,,I,CoA enzyme activase uncharacterised domain (DUF2229)
GC_00001482,NA,NA,,,C,"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis"
GC_00000260,K06187,recombination protein RecR,recR,ko:K06187,L,May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GC_00000006,K03406,methyl-accepting chemotaxis protein,,ko:K03406,NT,Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
GC_00000007,K02033,peptide/nickel transport system permease protein,,ko:K02033,P,Binding-protein-dependent transport system inner membrane component
GC_00000261,K00099,1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267],dxr,ko:K00099,I,Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
GC_00001354,K00575,chemotaxis protein methyltransferase CheR [EC:2.1.1.80],cheR,ko:K00575,NT,Chemotaxis protein methyltransferase
GC_00000369,K03639,"GTP 3',8-cyclase [EC:4.1.99.22]",moaA,"ko:K03639,ko:K20967",H,"Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate"
GC_00000951,K02416,flagellar motor switch protein FliM,fliM,ko:K02416,N,Flagellar motor switch protein FliM
GC_00000094,K02111,F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1],atpA,ko:K02111,C,Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GC_00000095,K02036,phosphate transport system ATP-binding protein [EC:7.3.2.1],pstB,ko:K02036,P,Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
GC_00010249,NA,NA,dsrL,,C,PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase
GC_00000481,K03797,carboxyl-terminal processing protease [EC:3.4.21.102],ctpA,ko:K03797,M,tail specific protease
GC_00000480,K03587,cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4],ftsI,"ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556",M,Penicillin-binding Protein dimerisation domain
GC_00000810,K00765,ATP phosphoribosyltransferase [EC:2.4.2.17],hisG,"ko:K00765,ko:K02502",F,Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
GC_00000229,K00573,protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77],pcm,ko:K00573,J,Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GC_00000228,K02499,tetrapyrrole methylase family protein / MazG family protein,mazG,"ko:K02428,ko:K02499,ko:K04765",S,MazG nucleotide pyrophosphohydrolase domain
GC_00000413,K00826,branched-chain amino acid aminotransferase [EC:2.6.1.42],ilvE,ko:K00826,E,Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GC_00000412,K03636,sulfur-carrier protein,,"ko:K03636,ko:K21147",H,ThiS family
GC_00009105,K11473,glycolate oxidase iron-sulfur subunit,,ko:K11473,C,PFAM Cysteine-rich domain
GC_00000588,K01703,3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35],leuC,ko:K01703,H,"Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate"
GC_00000147,K03768,peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8],,"ko:K01802,ko:K03768",O,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GC_00000321,K01866,tyrosyl-tRNA synthetase [EC:6.1.1.1],,,,
GC_00000320,K01495,GTP cyclohydrolase IA [EC:3.5.4.16],folE,"ko:K00950,ko:K01495",H,GTP cyclohydrolase I
GC_00000146,K06861,lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-],lptB,"ko:K01990,ko:K06861",S,ABC transporter
GC_00000243,K01652,acetolactate synthase I/II/III large subunit [EC:2.2.1.6],ilvI,ko:K01652,H,"Thiamine pyrophosphate enzyme, N-terminal TPP binding domain"
GC_00000024,K03704,cold shock protein,,,,
GC_00000242,K00794,"6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]",ribH,ko:K00794,H,"Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin"
GC_00035587,NA,NA,,,C,Nitrite and sulphite reductase 4Fe-4S domain
GC_00007219,NA,NA,,,S,Conserved Protein
GC_00000717,K01129,dGTPase [EC:3.1.5.1],dgt,ko:K01129,F,Belongs to the dGTPase family. Type 2 subfamily
GC_00008407,NA,NA,,ko:K05881,G,phosphoenolpyruvate-dependent sugar phosphotransferase system
GC_00032375,NA,NA,,,M,NA|NA|NA
GC_00000785,K04562,flagellar biosynthesis protein FlhG,flhG,"ko:K02282,ko:K04562",D,Cellulose biosynthesis protein BcsQ
GC_00001018,K01992,ABC-2 type transport system permease protein,yxlG,ko:K01992,S,ABC-2 family transporter protein
GC_00001847,K01610,phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49],pckA,ko:K01610,H,Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GC_00000478,K00133,aspartate-semialdehyde dehydrogenase [EC:1.2.1.11],asd,ko:K00133,E,Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GC_00000539,K03111,single-strand DNA-binding protein,ssb,ko:K03111,L,Single-strand binding protein family
GC_00000390,K01255,leucyl aminopeptidase [EC:3.4.11.1],pepA,"ko:K01255,ko:K01259",E,Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GC_00000391,K00766,anthranilate phosphoribosyltransferase [EC:2.4.2.18],trpD,"ko:K00766,ko:K13497",E,Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GC_00017993,K13643,"Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor",cymR,ko:K17472,K,"TIGRFAM transcriptional regulator, Rrf2 family"
GC_00007704,K03699,putative hemolysin,,ko:K03699,E,flavin adenine dinucleotide binding
GC_00000430,K03271,D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28],gmhA,ko:K03271,G,Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate
GC_00000431,K02066,phospholipid/cholesterol/gamma-HCH transport system permease protein,,,,
GC_00000657,K03517,quinolinate synthase [EC:2.5.1.72],nadA,ko:K03517,H,Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GC_00000298,K02963,small subunit ribosomal protein S18,rpsR,ko:K02963,J,"Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit"
GC_00003330,K02108,F-type H+-transporting ATPase subunit a,atpB,ko:K02108,C,it plays a direct role in the translocation of protons across the membrane
GC_00000299,K01933,phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1],,,,
GC_00000164,K03572,DNA mismatch repair protein MutL,mutL,ko:K03572,L,"This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex"
GC_00000302,K00796,dihydropteroate synthase [EC:2.5.1.15],folP,ko:K00796,H,"Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives"
GC_00000303,K03621,phosphate acyltransferase [EC:2.3.1.274],plsX,"ko:K03621,ko:K21576,ko:K21577",I,"Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA"
GC_00000165,K02115,F-type H+-transporting ATPase subunit gamma,atpG,ko:K02115,C,Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GC_00001787,K01778,diaminopimelate epimerase [EC:5.1.1.7],dapF,ko:K01778,E,"Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan"
GC_00003681,NA,NA,petB,"ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879",C,Cytochrome b/b6/petB
GC_00000181,K02886,large subunit ribosomal protein L2,rplB,ko:K02886,J,"One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity"
GC_00000180,K01845,"glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]",hemL,ko:K01845,H,Aminotransferase class-III
GC_00000845,K01736,chorismate synthase [EC:4.2.3.5],aroC,ko:K01736,E,"Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system"
GC_00016627,K06076,long-chain fatty acid transport protein,,,,
GC_00000447,K00969,nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18],nadD,"ko:K00969,ko:K03574",H,Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GC_00000446,K07263,zinc protease [EC:3.4.24.-],,,,
GC_00000089,K01955,carbamoyl-phosphate synthase large subunit [EC:6.3.5.5],carB,ko:K01955,F,"Carbamoyl-phosphate synthetase large chain, oligomerisation domain"
GC_00001241,K07107,acyl-CoA thioester hydrolase [EC:3.1.2.-],ysmA,ko:K07107,S,Thioesterase-like superfamily
GC_00000088,K03529,chromosome segregation protein,smc,ko:K03529,D,Required for chromosome condensation and partitioning
GC_00000375,K04485,DNA repair protein RadA/Sms,radA,ko:K04485,O,"DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function"
GC_00000113,K00789,S-adenosylmethionine synthetase [EC:2.5.1.6],metK,ko:K00789,H,"Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme"
GC_00000112,K00962,polyribonucleotide nucleotidyltransferase [EC:2.7.7.8],pnp,ko:K00962,J,Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
GC_00000374,K19225,rhomboid protease GluP [EC:3.4.21.105],,ko:K07059,S,Rhomboid family
GC_00000052,K00340,NADH-quinone oxidoreductase subunit K [EC:7.1.1.2],nuoK,"ko:K00340,ko:K05576",C,"NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient"
GC_00000234,K01698,porphobilinogen synthase [EC:4.2.1.24],hemB,ko:K01698,H,Delta-aminolevulinic acid dehydratase
GC_00000235,K01588,5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18],purE,ko:K01588,F,Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GC_00000053,K04751,nitrogen regulatory protein P-II 1,glnB,"ko:K04751,ko:K04752",K,Belongs to the P(II) protein family
GC_00001166,K06929,uncharacterized protein,yccU,ko:K06929,S,CoA binding domain
GC_00000506,K03092,RNA polymerase sigma-54 factor,rpoN,ko:K03092,K,"Sigma-54 factor, Activator interacting domain (AID)"
GC_00000507,K02501,imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10],hisH,ko:K02501,E,"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR"
GC_00000997,K11717,cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16],sufS,ko:K11717,E,"Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine"
GC_00000904,K06001,tryptophan synthase beta chain [EC:4.2.1.20],trpB,"ko:K01696,ko:K06001",E,The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GC_00000668,K12339,S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) [EC:2.5.1.144],cysM,"ko:K12339,ko:K21148",E,Pyridoxal-phosphate dependent enzyme
GC_00000669,K02198,cytochrome c-type biogenesis protein CcmF,ccmF,"ko:K02198,ko:K04016",O,PFAM Cytochrome c assembly protein
GC_00000931,NA,NA,,,,
GC_00000308,K13789,"geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]",ispA,"ko:K00795,ko:K02523,ko:K13789",H,Polyprenyl synthetase
GC_00000292,K01496,phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19],,,,
GC_00001406,K15231,ATP-citrate lyase beta-subunit [EC:2.3.3.8],,"ko:K15231,ko:K15232",H,ATP citrate lyase citrate-binding
GC_00000839,K00239,"succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]",frdA,"ko:K00239,ko:K00244",C,Fumarate reductase flavoprotein C-term
GC_00000200,K02881,large subunit ribosomal protein L18,rplR,ko:K02881,J,"This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance"
GC_00000201,K01945,phosphoribosylamine---glycine ligase [EC:6.3.4.13],purD,"ko:K01945,ko:K01952,ko:K13713",F,Belongs to the GARS family
GC_00000067,K07304,peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11],msrA,ko:K07304,O,Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GC_00000532,K00259,alanine dehydrogenase [EC:1.4.1.1],ald,ko:K00259,E,Belongs to the AlaDH PNT family
GC_00020563,NA,NA,,,S,Protein of unknown function (FYDLN_acid)
GC_00009024,K09694,lipooligosaccharide transport system permease protein,nodJ,ko:K09694,V,PFAM ABC-2 type transporter
GC_00000614,NA,NA,,,O,peptidyl-lysine modification to peptidyl-hypusine
GC_00000341,K01271,Xaa-Pro dipeptidase [EC:3.4.13.9],,,,
GC_00000127,K03596,GTP-binding protein LepA,lepA,ko:K03596,M,"Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner"
GC_00000126,K00134,glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12],gap,ko:K00134,C,Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
GC_00000340,K01719,uroporphyrinogen-III synthase [EC:4.2.1.75],cobA,"ko:K01719,ko:K02302,ko:K02303,ko:K13542",H,Belongs to the precorrin methyltransferase family
GC_00001188,K00995,CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5],pgsA,ko:K00995,I,Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GC_00004910,K06218,mRNA interferase RelE/StbE,relE,ko:K06218,DJ,"ParE toxin of type II toxin-antitoxin system, parDE"
GC_00000249,K01649,2-isopropylmalate synthase [EC:2.3.3.13],leuA,ko:K01649,E,Belongs to the alpha-IPM synthase homocitrate synthase family
GC_00000687,K10773,endonuclease III [EC:4.2.99.18],nth,"ko:K01142,ko:K10773",L,"DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate"
GC_00000686,NA,NA,,,S,Uncharacterised protein family UPF0047
GC_00000870,NA,NA,yicC,,S,Domain of unknown function (DUF1732)
GC_00000404,K06864,"pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase [EC:4.4.1.37]",larE,"ko:K06864,ko:K09121",L,tRNA processing
GC_00000405,K00145,N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38],argC,ko:K00145,E,Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GC_00000895,K00175,2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11],korB,ko:K00175,C,COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin
GC_00000336,K00940,nucleoside-diphosphate kinase [EC:2.7.4.6],ndk,ko:K00940,F,"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate"
GC_00000337,K00567,methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63],ogt,ko:K00567,L,Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GC_00000151,K01465,dihydroorotase [EC:3.5.2.3],pyrC,ko:K01465,F,Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
GC_00015657,NA,NA,VPA0557,,M,Outer membrane lipoprotein-sorting protein
GC_00000058,K04077,chaperonin GroEL,groL,ko:K04077,O,Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
GC_00001291,K01647,citrate synthase [EC:2.3.3.1],gltA,ko:K01647,C,Belongs to the citrate synthase family
GC_00000059,K01885,glutamyl-tRNA synthetase [EC:6.1.1.17],gltX,"ko:K01885,ko:K09698",J,Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GC_00001438,NA,NA,,,H,Thiamine biosynthesis protein (ThiI)
GC_00000807,K09804,uncharacterized protein,,ko:K09804,S,Protein of unknown function (DUF507)
GC_00000947,K02018,molybdate transport system permease protein,modB,"ko:K02018,ko:K15496",P,molybdate abc transporter
GC_00000119,K01937,CTP synthase [EC:6.3.4.2],pyrG,ko:K01937,F,Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
GC_00000118,NA,NA,,,S,Protein of unknown function (DUF433)
GC_00001873,K01423,beta-barrel assembly-enhancing protease [EC:3.4.-.-],,,S,Peptidase family M48
GC_00006745,K06607,myo-inositol catabolism protein IolS [EC:1.1.1.-],yhdN,,C,Aldo Keto reductase
GC_00000083,K00626,acetyl-CoA C-acetyltransferase [EC:2.3.1.9],,ko:K00626,I,Belongs to the thiolase family
GC_00000082,K02031,peptide/nickel transport system ATP-binding protein,oppD,"ko:K02031,ko:K02032,ko:K15583",P,Belongs to the ABC transporter superfamily
GC_00029557,NA,NA,,ko:K01992,S,ABC-2 family transporter protein
GC_00021646,K22225,siroheme decarboxylase [EC:4.1.1.111],nirD,,K,"SMART Transcription regulator, AsnC-type"
GC_00000277,K02437,glycine cleavage system H protein,,,,
GC_00000011,K02454,general secretion pathway protein E [EC:7.4.2.8],gspE,"ko:K02454,ko:K02652",NU,PFAM Type II secretion system protein E
GC_00027180,K02004,putative ABC transport system permease protein,,ko:K09808,M,ABC-type transport system involved in lipoprotein release permease component
GC_00005913,K22227,AdoMet-dependent heme synthase [EC:1.3.98.6],,,S,Proto-chlorophyllide reductase 57 kD subunit
GC_00000544,K04085,tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-],,ko:K00392,O,Sulfurtransferase TusA
GC_00027845,NA,NA,,ko:K00185,C,"PFAM Polysulphide reductase, NrfD"
GC_00000134,K00806,undecaprenyl diphosphate synthase [EC:2.5.1.31],uppS,"ko:K00806,ko:K14215,ko:K21273",I,Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GC_00000135,K00981,phosphatidate cytidylyltransferase [EC:2.7.7.41],cdsA,ko:K00981,S,Cytidylyltransferase family
GC_00000460,K04094,methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74],trmFO,ko:K04094,J,Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GC_00000461,K01814,phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16],hisA,ko:K01814,E,Histidine biosynthesis protein
GC_00001266,K03386,peroxiredoxin 2/4 [EC:1.11.1.24],ahpC,ko:K03386,O,AhpC/TSA family
GC_00000569,K03703,excinuclease ABC subunit C,uvrC,ko:K03703,L,The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
GC_00001108,K11180,dissimilatory sulfite reductase alpha subunit [EC:1.8.99.5],dsrA,ko:K11180,C,Nitrite and sulphite reductase 4Fe-4S
GC_00001109,K11181,dissimilatory sulfite reductase beta subunit [EC:1.8.99.5],dsrB,ko:K11181,C,Nitrite and sulphite reductase 4Fe-4S
GC_00006546,K02415,flagellar protein FliL,fliL,ko:K02415,N,Controls the rotational direction of flagella during chemotaxis
GC_00000428,K06960,uncharacterized protein,CP_0026,ko:K06960,S,Belongs to the UPF0109 family
GC_00000923,K21071,ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90],pfkA,"ko:K00850,ko:K21071",G,"Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis"
GC_00021110,K02662,type IV pilus assembly protein PilM,pilM,ko:K02662,NU,Type IV pilus assembly protein PilM;
GC_00000520,K00772,5'-methylthioadenosine phosphorylase [EC:2.4.2.28],adoK,"ko:K00852,ko:K00856",G,pfkB family carbohydrate kinase
GC_00027821,K10914,"CRP/FNR family transcriptional regulator, cyclic AMP receptor protein",,ko:K10914,T,Cyclic nucleotide-monophosphate binding domain
GC_00000213,K03588,cell division protein FtsW,ftsW,"ko:K02563,ko:K03588",D,Cell cycle protein
GC_00000075,K02469,DNA gyrase subunit A [EC:5.6.2.2],gyrA,ko:K02469,L,"A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner"
GC_00000074,K02650,type IV pilus assembly protein PilA,pilA,ko:K02650,NU,Prokaryotic N-terminal methylation motif
GC_00000212,K01783,ribulose-phosphate 3-epimerase [EC:5.1.3.1],rpe,ko:K01783,G,Ribulose-phosphate 3 epimerase family
GC_00003512,K00278,L-aspartate oxidase [EC:1.4.3.16],nadB,"ko:K00244,ko:K00278",H,Catalyzes the oxidation of L-aspartate to iminoaspartate
GC_00003982,K00548,5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],,ko:K00548,E,Homocysteine S-methyltransferase
GC_00003139,K03089,RNA polymerase sigma-32 factor,rpoH,ko:K03089,K,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GC_00000090,K02112,F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1],atpD,ko:K02112,C,Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GC_00000091,K03043,DNA-directed RNA polymerase subunit beta [EC:2.7.7.6],rpoB,"ko:K03043,ko:K13797",K,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GC_00000198,K00611,ornithine carbamoyltransferase [EC:2.1.3.3],argF,ko:K00611,E,Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GC_00013995,K03527,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],ispH,"ko:K00945,ko:K02945,ko:K03527",IM,Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GC_00000199,K02871,large subunit ribosomal protein L13,rplM,ko:K02871,J,"This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly"
GC_00020997,NA,NA,,ko:K00721,M,Involved in cell wall
GC_00000557,K03602,exodeoxyribonuclease VII small subunit [EC:3.1.11.6],xseB,ko:K03602,L,exodeoxyribonuclease VII activity
GC_00000731,K04488,nitrogen fixation protein NifU and related proteins,nifU,ko:K02612,S,Pfam:DUF59
GC_00000002,K13587,"two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]",,,T,His Kinase A (phosphoacceptor) domain
GC_00000265,K02959,small subunit ribosomal protein S16,rpsP,ko:K02959,J,Belongs to the bacterial ribosomal protein bS16 family
GC_00000003,K11527,"two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]",,,,
GC_00000325,K01881,prolyl-tRNA synthetase [EC:6.1.1.15],proS,ko:K01881,J,"Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS"
GC_00000143,K03040,DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6],rpoA,ko:K03040,K,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GC_00000142,K02835,peptide chain release factor 1,prfA,ko:K02835,J,Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GC_00000324,K09769,uncharacterized protein,,,,
GC_00000417,K01902,succinyl-CoA synthetase alpha subunit [EC:6.2.1.5],sucD,ko:K01902,C,"Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit"
GC_00000416,K14261,alanine-synthesizing transaminase [EC:2.6.1.-],yfdZ,"ko:K10206,ko:K14261",E,Aminotransferase class I and II
GC_00000779,K21071,ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90],pfp,"ko:K00850,ko:K00895,ko:K21071",H,"Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions"
GC_00000778,K06168,tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3],,,,
GC_00003827,NA,NA,,,G,NA|NA|NA
GC_00000219,K02965,small subunit ribosomal protein S19,rpsS,ko:K02965,J,Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GC_00024221,K03465,thymidylate synthase (FAD) [EC:2.1.1.148],thyX,ko:K03465,F,Thymidylate synthase complementing protein
GC_00000218,K02899,large subunit ribosomal protein L27,rpmA,ko:K02899,J,Belongs to the bacterial ribosomal protein bL27 family
GC_00000820,K01462,peptide deformylase [EC:3.5.1.88],def2,ko:K01462,J,Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
GC_00000382,K01662,1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7],dxs,ko:K01662,H,Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GC_00000311,K00989,ribonuclease PH [EC:2.7.7.56],rph,"ko:K00989,ko:K02428",J,Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GC_00027280,K02453,general secretion pathway protein D,gspD,"ko:K02453,ko:K03219",NU,Type II and III secretion system protein
GC_00000176,K02879,large subunit ribosomal protein L17,rplQ,"ko:K02879,ko:K16193",J,Ribosomal protein L17
GC_00000310,K18682,ribonucrease Y [EC:3.1.-.-],rny,ko:K18682,S,Endoribonuclease that initiates mRNA decay
GC_00000423,K00873,pyruvate kinase [EC:2.7.1.40],,,,
GC_00000645,NA,NA,acuC,,BQ,Histone deacetylase domain
GC_00034348,K02259,cytochrome c oxidase assembly protein subunit 15,,,,
GC_00000422,K03100,signal peptidase I [EC:3.4.21.89],lepB,ko:K03100,U,"Signal peptidase, peptidase S26"
GC_00000704,K06020,energy-dependent translational throttle protein EttA,,,,
GC_00000562,K03705,heat-inducible transcriptional repressor,hrcA,ko:K03705,K,Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
GC_00000563,K02666,type IV pilus assembly protein PilQ,pilQ,ko:K02666,U,Secretin and TonB N terminus short domain
GC_00001364,K02556,chemotaxis protein MotA,motA,ko:K02556,N,MotA/TolQ/ExbB proton channel family
GC_00007538,K09949,uncharacterized protein,cdsA2,"ko:K00748,ko:K09949",M,Protein of unknown function (DUF1009)
GC_00000036,K09458,3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179],fabF,ko:K09458,I,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
GC_00000250,K03644,lipoyl synthase [EC:2.8.1.8],lipA,ko:K03644,H,"Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives"
GC_00000251,K01972,DNA ligase (NAD+) [EC:6.5.1.2],,,,
GC_00007302,K22225,siroheme decarboxylase [EC:4.1.1.111],nirD,,K,AsnC-type helix-turn-helix domain
GC_00000961,K03088,"RNA polymerase sigma-70 factor, ECF subfamily",,ko:K03088,K,RNA polymerase sigma factor
GC_00000358,K01940,argininosuccinate synthase [EC:6.3.4.5],argG,ko:K01940,E,Belongs to the argininosuccinate synthase family. Type 1 subfamily
GC_00000359,K00963,UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9],,,,
GC_00002038,K01356,repressor LexA [EC:3.4.21.88],lexA,ko:K01356,K,"Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair"
GC_00002413,K07092,uncharacterized protein,perX,,S,DsrE/DsrF/DrsH-like family
GC_00039255,K02397,flagellar hook-associated protein 3 FlgL,flgL,ko:K02397,N,bacterial-type flagellum-dependent cell motility
GC_00000227,K03551,holliday junction DNA helicase RuvB [EC:3.6.4.12],ruvB,ko:K03551,L,"The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing"
GC_00000041,K02003,putative ABC transport system ATP-binding protein,macB,ko:K02003,V,ABC transporter
GC_00001289,K22227,AdoMet-dependent heme synthase [EC:1.3.98.6],,,C,Iron-sulfur cluster-binding domain
GC_00000226,K00088,IMP dehydrogenase [EC:1.1.1.205],guaB,ko:K00088,F,"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth"
GC_00010129,K12941,aminobenzoyl-glutamate utilization protein B,,,S,Peptidase dimerisation domain
GC_00000586,K02428,XTP/dITP diphosphohydrolase [EC:3.6.1.66],rdgB,"ko:K01776,ko:K02428",F,"Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions"
GC_00000149,K03531,cell division protein FtsZ,ftsZ,ko:K03531,D,Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GC_00000148,K03106,signal recognition particle subunit SRP54 [EC:3.6.5.4],,,,
GC_00000008,K06147,"ATP-binding cassette, subfamily B, bacterial",msbA,"ko:K02021,ko:K06147,ko:K11085",V,Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
GC_00019683,K08738,cytochrome c,psbV,ko:K02720,C,PFAM Class III cytochrome C family
GC_00004061,NA,NA,,,,
GC_00000009,K02034,peptide/nickel transport system permease protein,,ko:K02034,EP,PFAM binding-protein-dependent transport systems inner membrane component
GC_00000857,K02035,peptide/nickel transport system substrate-binding protein,appA,ko:K02035,E,"Extracellular solute-binding protein, family 5"
GC_00000192,K02003,putative ABC transport system ATP-binding protein,lolD,ko:K09810,V,"Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner"
GC_00000193,K02838,ribosome recycling factor,frr,ko:K02838,J,Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
GC_00003864,K02007,cobalt/nickel transport system permease protein,cbiM,ko:K02007,P,Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GC_00000100,K03628,transcription termination factor Rho,rho,"ko:K02887,ko:K03628",K,"Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template"
GC_00000366,K00767,nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19],nadC,"ko:K00278,ko:K00767",H,Belongs to the NadC ModD family
GC_00000367,K03497,"ParB family transcriptional regulator, chromosome partitioning protein",parB,ko:K03497,K,Belongs to the ParB family
GC_00000101,K03544,ATP-dependent Clp protease ATP-binding subunit ClpX,clpX,ko:K03544,O,ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GC_00023162,K21307,sulfite dehydrogenase (quinone) subunit SoeA [EC:1.8.5.6],dmsA,ko:K21307,C,Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GC_00000632,K03786,3-dehydroquinate dehydratase II [EC:4.2.1.10],aroQ,ko:K03786,E,Catalyzes a trans-dehydration via an enolate intermediate
GC_00000454,K00605,aminomethyltransferase [EC:2.1.2.10],gcvT,ko:K00605,E,The glycine cleavage system catalyzes the degradation of glycine
GC_00000455,NA,NA,ywhC,ko:K06402,S,Peptidase family M50
GC_00000633,K00974,tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-],cca,"ko:K00970,ko:K00974,ko:K06881",J,Probable RNA and SrmB- binding site of polymerase A
GC_00003050,K03605,hydrogenase maturation protease [EC:3.4.23.-],hybD,ko:K03605,C,Hydrogenase maturation protease
GC_00000204,K03110,fused signal recognition particle receptor,ftsY,ko:K03110,U,Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
GC_00000062,K01738,cysteine synthase [EC:2.5.1.47],cysK,ko:K01738,E,Pyridoxal-phosphate dependent enzyme
GC_00000063,K22024,4-phospho-D-threonate 3-dehydrogenase / 4-phospho-D-erythronate 3-dehydrogenase [EC:1.1.1.408 1.1.1.409],pdxA,"ko:K00097,ko:K22024",C,Pyridoxal phosphate biosynthetic protein PdxA
GC_00000296,K01693,imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19],hisB,"ko:K00013,ko:K00817,ko:K01089,ko:K01693",E,Imidazoleglycerol-phosphate dehydratase
GC_00000297,K01006,"pyruvate, orthophosphate dikinase [EC:2.7.9.1]",ppdK,"ko:K01006,ko:K22424",G,Belongs to the PEP-utilizing enzyme family
GC_00027160,K01990,ABC-2 type transport system ATP-binding protein,,ko:K01990,S,ABC transporter
GC_00000875,K03635,molybdopterin synthase catalytic subunit [EC:2.8.1.12],moaE,ko:K03635,H,MoaE protein
GC_00029038,K02276,cytochrome c oxidase subunit III [EC:7.1.1.9],ctaE,ko:K02276,C,"cytochrome c oxidase, subunit III"
GC_00000123,K13017,UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98],degT,,E,Belongs to the DegT DnrJ EryC1 family
GC_00000345,K03522,electron transfer flavoprotein alpha subunit,fixB,ko:K03522,C,"electron transfer flavoprotein, alpha subunit"
GC_00000344,K01928,"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]",murE,"ko:K01928,ko:K15792",M,acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GC_00000122,K03702,excinuclease ABC subunit B,,,,
GC_00001724,K07168,CBS domain-containing membrane protein,,,S,PFAM CBS domain
GC_00003111,K01151,deoxyribonuclease IV [EC:3.1.21.2],nfo,ko:K01151,L,Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GC_00000611,K13256,protein PsiE,rub,,C,Rubredoxin
GC_00000477,K01695,tryptophan synthase alpha chain [EC:4.2.1.20],trpA,ko:K01695,E,The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
GC_00000476,K03593,ATP-binding protein involved in chromosome partitioning,mrp,ko:K03593,D,Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
GC_00032658,K02275,cytochrome c oxidase subunit II [EC:7.1.1.9],coxB,"ko:K02275,ko:K17223",C,Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
GC_00012609,NA,NA,petB,"ko:K00410,ko:K00412,ko:K02635,ko:K02637",C,Cytochrome b(C-terminal)/b6/petD
GC_00000492,K04096,DNA processing protein,dprA,"ko:K03168,ko:K04096",L,DNA recombination-mediator protein A
GC_00000493,K23265,phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2],purQ,ko:K01952,F,Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GC_00000803,K09022,2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10],,ko:K09022,J,Endoribonuclease L-PSP
GC_00000508,K04085,tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-],cysI,"ko:K00362,ko:K00366,ko:K00381,ko:K00392",C,Nitrite and sulphite reductase 4Fe-4S domain
GC_00000509,K09767,cyclic-di-GMP-binding protein,yajQ,ko:K09767,S,Belongs to the UPF0234 family
GC_00000332,K02503,histidine triad (HIT) family protein,hinT,"ko:K02503,ko:K06442",FG,Scavenger mRNA decapping enzyme C-term binding
GC_00000155,K09903,uridylate kinase [EC:2.7.4.22],pyrH,ko:K09903,F,Catalyzes the reversible phosphorylation of UMP to UDP
GC_00000333,K01962,acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15],accA,"ko:K01962,ko:K01963",I,"Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA"
GC_00003167,K06180,23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23],rluD,"ko:K06177,ko:K06180",J,Responsible for synthesis of pseudouridine from uracil
GC_00001206,K16885,"quinone-modifying oxidoreductase, subunit QmoA",qmoA,"ko:K03388,ko:K16885,ko:K16886",C,FAD dependent oxidoreductase
GC_00022198,NA,NA,,,S,NYN domain
GC_00001061,K04096,DNA processing protein,,ko:K06966,S,Belongs to the LOG family
GC_00000890,K02231,adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62],cobU,"ko:K02231,ko:K02232",H,Cobinamide kinase / cobinamide phosphate guanyltransferase
GC_00000400,K00013,histidinol dehydrogenase [EC:1.1.1.23],hisD,"ko:K00013,ko:K15509",E,Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GC_00000666,K02394,flagellar P-ring protein FlgI,flgI,ko:K02394,N,Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GC_00000667,K09791,uncharacterized protein,ycaR,"ko:K00912,ko:K09791",S,Trm112p-like protein
GC_00000891,K00208,enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10],fabI,ko:K00208,I,Enoyl- acyl-carrier-protein reductase NADH
GC_00000541,K02492,glutamyl-tRNA reductase [EC:1.2.1.70],hemA,"ko:K02407,ko:K02492",H,Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GC_00003879,K00029,malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40],maeA,"ko:K00027,ko:K00029",C,"Malic enzyme, NAD binding domain"
GC_00004528,K03561,biopolymer transport protein ExbB,,,,
GC_00000726,K00283,glycine dehydrogenase subunit 2 [EC:1.4.4.2],,,,
GC_00001121,K02409,flagellar M-ring protein FliF,fliF,ko:K02409,N,The M ring may be actively involved in energy transduction
GC_00000015,K03116,sec-independent protein translocase protein TatA,tatA,ko:K03116,U,Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
GC_00000273,K05896,segregation and condensation protein A,scpA,ko:K05896,D,Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GC_00000272,K01627,2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55],kdsA,ko:K01627,M,DAHP synthetase I family
GC_00000449,K01887,arginyl-tRNA synthetase [EC:6.1.1.19],argS,ko:K01887,J,Arginyl tRNA synthetase N terminal dom
GC_00000448,K00931,glutamate 5-kinase [EC:2.7.2.11],proB,ko:K00931,E,Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GC_00000087,K05366,penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4],mrcA,ko:K05366,M,Penicillin-binding protein OB-like domain
GC_00000086,K02483,"two-component system, OmpR family, response regulator",,,K,"Transcriptional regulatory protein, C terminal"
GC_00012386,K03394,precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151],cobI,"ko:K02228,ko:K03394,ko:K13540",H,PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase
GC_00031019,NA,NA,ku,ko:K10979,L,"With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD"
GC_00004175,K02806,nitrogen PTS system EIIA component [EC:2.7.1.-],ptsN,"ko:K02768,ko:K02769,ko:K02770,ko:K02806",G,phosphoenolpyruvate-dependent sugar phosphotransferase system
GC_00007315,K03548,putative permease,perM,ko:K01923,D,permease
GC_00000129,K03630,DNA repair protein RadC,radC,ko:K03630,L,RadC-like JAB domain
GC_00000128,K03496,chromosome partitioning protein,soj,ko:K03496,D,Cellulose biosynthesis protein BcsQ
GC_00030083,NA,NA,,ko:K00721,M,Dolichyl-phosphate-mannose-protein mannosyltransferase
GC_00000976,K02304,precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4],cysG,ko:K02304,H,TIGRFAM siroheme synthase
GC_00001114,K06282,hydrogenase small subunit [EC:1.12.99.6],hyaS,ko:K06282,C,NiFe/NiFeSe hydrogenase small subunit C-terminal
GC_00000575,K00014,shikimate dehydrogenase [EC:1.1.1.25],aroE,ko:K00014,E,"Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)"
GC_00014029,K00169,pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1],porA,ko:K00169,C,Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GC_00000574,K03742,nicotinamide-nucleotide amidase [EC:3.5.1.42],cinA,"ko:K03742,ko:K03743",S,Competence-damaged protein
GC_00000712,K03186,flavin prenyltransferase [EC:2.5.1.129],ubiX,ko:K03186,H,Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
GC_00000021,K02355,elongation factor G,fusA,ko:K02355,J,"Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome"
GC_00000247,K03657,DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12],pcrA,"ko:K03656,ko:K03657",L,PFAM UvrD REP helicase
GC_00000246,K02500,imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10],hisF,ko:K02500,E,"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit"
GC_00008599,K06204,DnaK suppressor protein,,ko:K06204,T,zinc ion binding
GC_00003720,K03787,5'-nucleotidase [EC:3.1.3.5],surE,ko:K03787,S,Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GC_00002978,K11358,aspartate aminotransferase [EC:2.6.1.1],yhdR,ko:K11358,E,Aminotransferase
GC_00000688,K04087,modulator of FtsH protease HflC,hflC,ko:K04087,O,stress-induced mitochondrial fusion
GC_00001990,K01990,ABC-2 type transport system ATP-binding protein,nodI,"ko:K01990,ko:K09695",V,"AAA domain, putative AbiEii toxin, Type IV TA system"
GC_00000160,K01876,aspartyl-tRNA synthetase [EC:6.1.1.12],aspS,ko:K01876,J,Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GC_00000161,K02988,small subunit ribosomal protein S5,rpsE,ko:K02988,J,Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GC_00000307,K09457,7-cyano-7-deazaguanine reductase [EC:1.7.1.13],queF,ko:K09457,S,Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GC_00000653,K01591,orotidine-5'-phosphate decarboxylase [EC:4.1.1.23],pyrF,ko:K01591,F,Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
GC_00000435,K03977,GTPase,der,ko:K03977,S,GTPase that plays an essential role in the late steps of ribosome biogenesis
GC_00000837,K07040,uncharacterized protein,yceD,ko:K07040,S,"Uncharacterized ACR, COG1399"
GC_00000068,K03466,"DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family",ftsK,ko:K03466,D,Ftsk_gamma
GC_00000069,K14652,"3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]",,,,
GC_00000394,NA,NA,,,S,Putative regulatory protein
GC_00032591,NA,NA,,,T,PhoQ Sensor
GC_00000117,K03320,"ammonium transporter, Amt family",amt,ko:K03320,P,Ammonium Transporter Family
GC_00000370,K00812,aspartate aminotransferase [EC:2.6.1.1],aspB,"ko:K00812,ko:K22457",E,"Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology"
GC_00000116,K01868,threonyl-tRNA synthetase [EC:6.1.1.3],thrS,ko:K01868,J,Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GC_00000625,K02419,flagellar biosynthesis protein FliP,fliP,"ko:K02419,ko:K03226",N,Plays a role in the flagellum-specific transport system
GC_00000443,K03470,ribonuclease HII [EC:3.1.26.4],rnhB,ko:K03470,L,Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GC_00000442,K03474,pyridoxine 5-phosphate synthase [EC:2.6.99.2],pdxJ,ko:K03474,H,Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GC_00001244,K01012,biotin synthase [EC:2.8.1.6],bioB,"ko:K00833,ko:K01012",H,Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GC_00004282,K03498,trk system potassium uptake protein,ktrB,ko:K03498,P,Cation transport protein
GC_00000279,K02890,large subunit ribosomal protein L22,rplV,ko:K02890,J,"The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome"
GC_00000185,K02956,small subunit ribosomal protein S15,rpsO,ko:K02956,J,Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GC_00000338,K01925,UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9],murD,ko:K01925,M,Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GC_00001396,K01069,hydroxyacylglutathione hydrolase [EC:3.1.2.6],gloB,ko:K01069,S,Metallo-beta-lactamase superfamily
GC_00022008,K01463,N-acetylglucosamine malate deacetylase 1 [EC:3.5.1.-],bshB1,ko:K01463,S,GlcNAc-PI de-N-acetylase
GC_00000900,K03606,putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase,wcaJ,ko:K03606,M,Bacterial sugar transferase
GC_00000591,K02400,flagellar biosynthesis protein FlhA,flhA,ko:K02400,N,"Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin"
GC_00000901,K11179,tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-],tusE,ko:K11179,P,part of a sulfur-relay system
GC_00001162,K00688,glycogen phosphorylase [EC:2.4.1.1],glgP,ko:K00688,G,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties"
GC_00001163,K00619,amino-acid N-acetyltransferase [EC:2.3.1.1],argH,"ko:K00619,ko:K14681",E,Belongs to the acetyltransferase family. ArgA subfamily
GC_00000502,K19710,ATP adenylyltransferase [EC:2.7.7.53],hit,ko:K19710,FG,PFAM Histidine triad (HIT) protein
GC_00000764,NA,NA,acnA,ko:K01681,C,Aconitase C-terminal domain
GC_00000765,K00566,tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13],mnmA,ko:K00566,J,"Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34"
GC_00000056,K00648,3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180],fabH,ko:K00648,I,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GC_00000057,K00059,3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100],,,,
GC_00000231,K01990,ABC-2 type transport system ATP-binding protein,ccmA,"ko:K01990,ko:K09697",V,ATPase activity
GC_00014164,K00800,3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19],aroA,ko:K00800,E,Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
GC_00000438,K08678,UDP-glucuronate decarboxylase [EC:4.1.1.35],rfbB,"ko:K01710,ko:K08678",M,3-beta hydroxysteroid dehydrogenase/isomerase family
GC_00000291,K03595,GTPase,,,,
GC_00000290,K00053,ketol-acid reductoisomerase [EC:1.1.1.86],ilvC,ko:K00053,H,"Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate"
GC_00000933,K08218,"MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG",ampG,ko:K08218,EGP,Acetyl-coenzyme A transporter 1
GC_00000932,K04653,hydrogenase expression/formation protein HypC,hypC,ko:K04653,O,carbon dioxide binding
GC_00016536,NA,NA,,ko:K00406,C,"Cytochrome C oxidase, cbb3-type, subunit III"
GC_00000531,K02926,large subunit ribosomal protein L4,rplD,"ko:K02926,ko:K16193",J,Ribosomal protein L4/L1 family
GC_00000399,K03149,thiazole synthase [EC:2.8.1.10],thiG,ko:K03149,H,"Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S"
GC_00001337,K15230,ATP-citrate lyase alpha-subunit [EC:2.3.3.8],,"ko:K01902,ko:K15230,ko:K15233",C,"Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit"
GC_00003764,K01056,"peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]",pth,ko:K01056,J,The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
GC_00000065,K01990,ABC-2 type transport system ATP-binding protein,,,,
GC_00000203,K02952,small subunit ribosomal protein S13,rpsM,ko:K02952,J,"Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits"
GC_00008113,K00338,NADH-quinone oxidoreductase subunit I [EC:7.1.1.2],nuoI,"ko:K00338,ko:K02573",C,"NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient"
GC_00000202,K02884,large subunit ribosomal protein L19,,,,
GC_00000064,K03723,transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-],mfd,ko:K03723,L,"Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site"
GC_00000342,K03074,preprotein translocase subunit SecF,secF,"ko:K03072,ko:K03074,ko:K12257",U,Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GC_00000125,K03076,preprotein translocase subunit SecY,secY,ko:K03076,U,"The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently"
GC_00000343,K06898,"pyridinium-3,5-biscarboxylic acid mononucleotide synthase [EC:2.5.1.143]",,,,
GC_00000470,K22205,S-adenosyl-L-methionine hydrolase (adenosine-forming) [EC:3.13.1.8],,ko:K22205,S,S-adenosyl-l-methionine hydroxide adenosyltransferase
GC_00000617,NA,NA,yfhL,"ko:K03522,ko:K05337",C,4Fe-4S dicluster domain
GC_00000684,K01921,D-alanine-D-alanine ligase [EC:6.3.2.4],ddl,ko:K01921,F,Cell wall formation
GC_00000685,NA,NA,,"ko:K00128,ko:K00131",C,Aldehyde dehydrogenase family
GC_00015444,K00374,nitrate reductase gamma subunit [EC:1.7.5.1 1.7.99.-],dsrM,ko:K00374,C,PFAM Nitrate reductase gamma subunit
GC_00000579,K03799,heat shock protein HtpX [EC:3.4.24.-],htpX,ko:K03799,O,Belongs to the peptidase M48B family
GC_00000153,K03072,preprotein translocase subunit SecD,secD,"ko:K03072,ko:K12257",U,Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GC_00000335,K09691,lipopolysaccharide transport system ATP-binding protein,,"ko:K01990,ko:K09689,ko:K09691",GM,ATPases associated with a variety of cellular activities
GC_00000334,K11175,phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2],purN,"ko:K11175,ko:K13713",F,"Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate"
GC_00000152,K04567,"lysyl-tRNA synthetase, class II [EC:6.1.1.6]",lysS,ko:K04567,J,Belongs to the class-II aminoacyl-tRNA synthetase family
GC_00001067,K00817,histidinol-phosphate aminotransferase [EC:2.6.1.9],hisC,ko:K00817,E,Aminotransferase class I and II
GC_00001066,K00394,"adenylylsulfate reductase, subunit A [EC:1.8.99.2]",aprA,ko:K00394,C,FAD binding domain
GC_00000406,K01889,phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20],pheS,ko:K01889,J,Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GC_00000805,K03407,"two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]",cheA,"ko:K02487,ko:K03407,ko:K06596",NT,Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
GC_00000495,K03926,periplasmic divalent cation tolerance protein,,,,
GC_00000804,K07263,zinc protease [EC:3.4.24.-],pqqL,ko:K07263,S,"Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology"
GC_00000494,K10026,7-carboxy-7-deazaguanine synthase [EC:4.3.99.3],queE,"ko:K04068,ko:K10026",H,"Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds"
GC_00007555,NA,NA,ygiQ,,C,UPF0313 protein
GC_00000768,K01737,6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50],queD,ko:K01737,H,6-pyruvoyl tetrahydropterin synthase
GC_00029486,K00390,phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10],cysH,"ko:K00366,ko:K00390,ko:K00860",EH,Belongs to the PAPS reductase family. CysH subfamily
GC_00000628,K09764,uncharacterized protein,ylxP,ko:K09764,S,Protein of unknown function (DUF503)
GC_00006746,K03559,biopolymer transport protein ExbD,,,,
GC_00000629,K02405,RNA polymerase sigma factor FliA,fliA,"ko:K02405,ko:K03093",K,"Sigma-70, region 4"
GC_00000080,K03046,DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6],rpoC,"ko:K03046,ko:K13797",K,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GC_00000081,K08999,uncharacterized protein,,"ko:K03617,ko:K08999",S,Bifunctional nuclease
GC_00000546,K00688,glycogen phosphorylase [EC:2.4.1.1],glgP,ko:K00688,G,Carbohydrate phosphorylase
GC_00005910,K03409,chemotaxis protein CheX,cheX,ko:K03409,N,Chemotaxis phosphatase CheX
GC_00001126,K02356,elongation factor P,efp,ko:K02356,J,"Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase"
GC_00000188,K02948,small subunit ribosomal protein S11,rpsK,ko:K02948,J,"Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome"
GC_00000189,K02994,small subunit ribosomal protein S8,rpsH,ko:K02994,J,"One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit"
GC_00000274,K01803,triosephosphate isomerase (TIM) [EC:5.3.1.1],tpiA,ko:K01803,G,Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
GC_00000012,K04763,integrase/recombinase XerD,xerC,"ko:K03733,ko:K04763",L,"Phage integrase, N-terminal SAM-like domain"
GC_00000013,K03686,molecular chaperone DnaJ,,,,
GC_00000275,K02939,large subunit ribosomal protein L9,,,,
GC_00008894,K02421,flagellar biosynthesis protein FliR,fliR,"ko:K02421,ko:K03228,ko:K13820",N,bacterial-type flagellum assembly
GC_00000714,K03147,phosphomethylpyrimidine synthase [EC:4.1.99.17],thiC,ko:K03147,H,Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GC_00000240,K00939,adenylate kinase [EC:2.7.4.3],adk,ko:K00939,F,Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
GC_00000026,K01338,ATP-dependent Lon protease [EC:3.4.21.53],lon,ko:K01338,O,"ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner"
GC_00000241,K03664,SsrA-binding protein,smpB,ko:K03664,O,"the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA"
GC_00007528,K06194,lipoprotein NlpD,,,M,heme binding
GC_00000879,K00297,methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20],metF,ko:K00297,C,Methylenetetrahydrofolate reductase
GC_00000348,K01950,NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1],nadE,"ko:K01916,ko:K01950",H,Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GC_00000349,K03655,ATP-dependent DNA helicase RecG [EC:3.6.4.12],,,,
GC_00004588,K22226,Fe-coproporphyrin III synthase,nirJ,ko:K22226,C,Iron-sulfur cluster-binding domain
GC_00000787,K03308,"neurotransmitter:Na+ symporter, NSS family",,ko:K03308,S,Sodium:neurotransmitter symporter family
GC_00000971,K01494,dCTP deaminase [EC:3.5.4.13],dcd,ko:K01494,F,2'-deoxycytidine 5'-triphosphate deaminase (DCD)
GC_00000208,K02874,large subunit ribosomal protein L14,rplN,ko:K02874,J,Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GC_00000393,K03526,(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3],,,,
GC_00000392,K01092,myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25],suhB,ko:K01092,G,Inositol monophosphatase family
GC_00000167,K01756,adenylosuccinate lyase [EC:4.3.2.2],purB,ko:K01756,F,Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GC_00000301,K00606,3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11],panB,ko:K00606,H,"Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate"
GC_00000166,K01358,"ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]",clpP,ko:K01358,O,Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
GC_00000655,K02654,leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-],pilD,"ko:K02236,ko:K02278,ko:K02506,ko:K02654,ko:K10966",NOU,Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GC_00000433,K02536,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191],lpxD,ko:K02536,M,"Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell"
GC_00000432,K03424,TatD DNase family protein [EC:3.1.21.-],ycfH,ko:K03424,L,TatD related DNase
GC_00001053,K02456,general secretion pathway protein G,gspG,"ko:K02246,ko:K02456",NU,Prokaryotic N-terminal methylation motif
GC_00003154,NA,NA,adhA7,"ko:K00001,ko:K00004,ko:K00098",E,PFAM Alcohol dehydrogenase
GC_00000846,K07457,endonuclease III related protein,magIII,ko:K07457,L,endonuclease III
GC_00000018,K03086,RNA polymerase primary sigma factor,rpoD,ko:K03086,K,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GC_00021923,NA,NA,,ko:K01992,S,Putative ATP-binding cassette
GC_00000182,K08963,methylthioribose-1-phosphate isomerase [EC:5.3.1.23],mtnA,ko:K08963,J,Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GC_00000183,K00975,glucose-1-phosphate adenylyltransferase [EC:2.7.7.27],glgC,ko:K00975,H,"Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans"
GC_00000376,K06207,GTP-binding protein,typA,ko:K06207,T,GTP-binding protein TypA
GC_00000110,K03555,DNA mismatch repair protein MutS,mutS,ko:K03555,L,that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GC_00000111,K03217,YidC/Oxa1 family membrane protein insertase,yidC,ko:K03217,U,"Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins"
GC_00000377,K02160,acetyl-CoA carboxylase biotin carboxyl carrier protein,,,,
GC_00000444,NA,NA,ycgE,"ko:K19591,ko:K22491",K,"helix_turn_helix, mercury resistance"
GC_00000623,K22074,"NFU1 iron-sulfur cluster scaffold homolog, mitochondrial",nifU,,O,iron-sulfur cluster assembly
GC_00000445,K00003,homoserine dehydrogenase [EC:1.1.1.3],,,,
GC_00000763,K02626,arginine decarboxylase [EC:4.1.1.19],pdaD,ko:K02626,S,Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)
GC_00000505,K02435,aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7],gatC,ko:K02435,J,Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GC_00000995,K00950,2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3],,,,
GC_00000237,K08301,ribonuclease G [EC:3.1.26.-],rng,ko:K08301,J,Ribonuclease E/G family
GC_00000050,K03569,rod shape-determining protein MreB and related proteins,mreB,ko:K03569,D,Actin
GC_00029584,NA,NA,,,P,NA|NA|NA
GC_00000159,K02520,translation initiation factor IF-3,infC,ko:K02520,J,"IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins"
GC_00000158,K00773,queuine tRNA-ribosyltransferase [EC:2.4.2.29],tgt,ko:K00773,J,"Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)"
GC_00000597,K01960,pyruvate carboxylase subunit B [EC:6.4.1.1],oadA,"ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K20140",C,Conserved carboxylase domain
GC_00025991,K02004,putative ABC transport system permease protein,VPA0558,ko:K09808,M,MacB-like periplasmic core domain
GC_00000692,K03831,molybdopterin adenylyltransferase [EC:2.7.7.75],mog,"ko:K03635,ko:K03831",H,Probable molybdopterin binding domain
GC_00011931,K03411,chemotaxis protein CheD [EC:3.5.1.44],cheD,"ko:K03411,ko:K03412",NT,"Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis"
GC_00001368,K00174,2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11],,ko:K00174,C,Pyruvate:ferredoxin oxidoreductase core domain II
GC_00000133,K19304,murein DD-endopeptidase [EC:3.4.24.-],,ko:K21471,M,Peptidase family M23
GC_00000132,K02314,replicative DNA helicase [EC:3.6.4.12],dnaB,ko:K02314,L,Participates in initiation and elongation during chromosome replication
GC_00000354,K23997,ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase [EC:4.2.1.136 5.1.99.6],nnrD,"ko:K17758,ko:K17759",H,"Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration"
GC_00000600,K03182,4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98],,,,
GC_00000466,K03550,holliday junction DNA helicase RuvA [EC:3.6.4.12],ruvA,ko:K03550,L,"The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB"
GC_00001260,K09014,Fe-S cluster assembly protein SufB,sufB,"ko:K07033,ko:K09014",O,Uncharacterized protein family (UPF0051)
GC_00011614,NA,NA,,ko:K10914,T,Cyclic nucleotide-monophosphate binding domain
GC_00000740,K00282,glycine dehydrogenase subunit 1 [EC:1.4.4.2],,,,
GC_00001588,K22451,4-alpha-glucanotransferase [EC:2.4.1.25],amyA,ko:K22451,G,Belongs to the glycosyl hydrolase 57 family
GC_00000527,K00652,8-amino-7-oxononanoate synthase [EC:2.3.1.47],bioF,"ko:K00639,ko:K00652",H,"Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide"
GC_00002420,K03499,trk system potassium uptake protein,trkA,ko:K03499,P,TrkA-N domain
GC_00030224,K02189,cobalt-precorrin 5A hydrolase [EC:3.7.1.12],cbiG,"ko:K02189,ko:K05934,ko:K05936,ko:K13541",H,Cobalamin synthesis G C-terminus
GC_00000072,K03642,rare lipoprotein A,rlpA,ko:K03642,M,Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GC_00000214,K00147,glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41],proA,ko:K00147,E,Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GC_00032410,K00991,2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60],ispD,"ko:K00991,ko:K12506",I,Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
GC_00000215,K06024,segregation and condensation protein B,scpB,ko:K06024,D,Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GC_00000286,K00057,glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94],gpsA,ko:K00057,I,NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
GC_00000287,K07478,putative ATPase,rarA,ko:K07478,L,MgsA AAA+ ATPase C terminal
GC_00000551,K03210,preprotein translocase subunit YajC,yajC,ko:K03210,U,Preprotein translocase subunit
GC_00005907,K03408,purine-binding chemotaxis protein CheW,cheW2,ko:K03408,NT,Two component signalling adaptor domain
GC_00000736,K00979,3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38],kdsB,ko:K00979,M,Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GC_00024568,K08602,oligoendopeptidase F [EC:3.4.24.-],pepF,ko:K08602,E,"TIGRFAM oligoendopeptidase, M3 family"
GC_00000263,K00927,phosphoglycerate kinase [EC:2.7.2.3],,,,
GC_00000005,K07814,putative two-component system response regulator,,ko:K07814,T,HD domain
GC_00034508,K07114,Ca-activated chloride channel homolog,batA,ko:K07114,NU,von Willebrand factor (vWF) type A domain
GC_00000004,K12132,eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1],,,,
GC_00000262,K06442,23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227],,,,
GC_00001464,K15539,cytoskeleton protein RodZ,,ko:K15539,S,Domain of unknown function (DUF4115)
GC_00000097,K03070,preprotein translocase subunit SecA [EC:7.4.2.8],secA,ko:K03070,U,"Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane"
GC_00000096,K01874,methionyl-tRNA synthetase [EC:6.1.1.10],metG,"ko:K01874,ko:K01890,ko:K04566,ko:K06878",J,Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GC_00002738,K15518,deoxyguanosine kinase [EC:2.7.1.113],dgk,ko:K15518,F,Deoxynucleoside kinase
GC_00000458,K00772,5'-methylthioadenosine phosphorylase [EC:2.4.2.28],mtnP,ko:K00772,F,"Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates"
GC_00000483,K06941,23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192],rlmN,ko:K06941,J,Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
GC_00002584,K02636,cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6],petA,"ko:K00411,ko:K02636,ko:K03886",C,Rieske [2Fe-2S] domain
GC_00025415,NA,NA,,,C,"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis"
GC_00001285,K15633,"2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]",gpmI,ko:K15633,G,Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GC_00000518,K11784,cyclic dehypoxanthinyl futalosine synthase [EC:1.21.98.1],,,,
GC_00001742,K03389,heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6],,,,
GC_00000144,K01000,phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13],,,,
GC_00000322,K01714,4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7],,,,
GC_00000145,K00948,ribose-phosphate pyrophosphokinase [EC:2.7.6.1],prs,ko:K00948,F,Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GC_00000410,K01915,glutamine synthetase [EC:6.3.1.2],glnA,ko:K01915,E,"Glutamine synthetase, catalytic domain"
GC_00000411,K01755,argininosuccinate lyase [EC:4.3.2.1],argH,ko:K01755,E,Argininosuccinate lyase C-terminal
GC_00000677,K03841,"fructose-1,6-bisphosphatase I [EC:3.1.3.11]",fbp,ko:K03841,G,"Fructose-1-6-bisphosphatase, N-terminal domain"
GC_00021246,K00339,NADH-quinone oxidoreductase subunit J [EC:7.1.1.2],nuoJ,ko:K00339,C,NADH-ubiquinone/plastoquinone oxidoreductase chain 6
GC_00007378,K00240,"succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4]",sdhB,ko:K00240,C,Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GC_00014582,K00172,pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1],porG,ko:K00172,C,"COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit"
GC_00000170,K03177,tRNA pseudouridine55 synthase [EC:5.4.99.25],truB,"ko:K03177,ko:K03483",J,Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GC_00000316,K02892,large subunit ribosomal protein L23,rplW,ko:K02892,J,One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
GC_00000317,K00525,ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1],,,,
GC_00000171,K07568,S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17],queA,ko:K07568,J,Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GC_00034977,K02338,DNA polymerase III subunit beta [EC:2.7.7.7],dnaN,ko:K02338,L,"Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria"
GC_00000424,K01903,succinyl-CoA synthetase beta subunit [EC:6.2.1.5],sucC,ko:K01903,C,"Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit"
GC_00000425,K00971,mannose-1-phosphate guanylyltransferase [EC:2.7.7.13],manC,"ko:K00971,ko:K01840,ko:K16011",M,Belongs to the mannose-6-phosphate isomerase type 2 family
GC_00032221,K18917,mycoredoxin [EC:1.20.4.3],,,O,Glutaredoxin
GC_00000079,K02032,peptide/nickel transport system ATP-binding protein,,"ko:K02032,ko:K10823",P,Belongs to the ABC transporter superfamily
GC_00000385,K02904,large subunit ribosomal protein L29,,,,
GC_00016251,K06042,precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60],cobH,"ko:K02006,ko:K06042",H,Precorrin-8X methylmutase
GC_00001197,K16887,"quinone-modifying oxidoreductase, subunit QmoC",dld,"ko:K03390,ko:K16887,ko:K18930",C,4Fe-4S dicluster domain
GC_00000139,K03168,DNA topoisomerase I [EC:5.6.2.1],,,,
GC_00000138,K01924,UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8],murC,ko:K01924,M,Belongs to the MurCDEF family
GC_00001637,K03924,MoxR-like ATPase [EC:3.6.3.-],,,,
GC_00000699,K02110,F-type H+-transporting ATPase subunit c,atpE,ko:K02110,P,"F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation"
GC_00008588,K02197,cytochrome c-type biogenesis protein CcmE,ccmE,ko:K02197,O,Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GC_00007759,NA,NA,rpoS,ko:K03086,K,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GC_00000257,K03561,biopolymer transport protein ExbB,tolQ,"ko:K03561,ko:K03562",U,MotA/TolQ/ExbB proton channel family
GC_00000030,K03640,peptidoglycan-associated lipoprotein,pal,ko:K03640,M,Belongs to the ompA family
GC_00000256,K00604,methionyl-tRNA formyltransferase [EC:2.1.2.9],,,,
GC_00000581,K03530,DNA-binding protein HU-beta,hup,ko:K03530,L,regulation of translation
GC_00000911,K00958,sulfate adenylyltransferase [EC:2.7.7.4],sat,ko:K00958,P,Belongs to the sulfate adenylyltransferase family
GC_00000328,K02906,large subunit ribosomal protein L3,,,,
GC_00000329,K00382,dihydrolipoamide dehydrogenase [EC:1.8.1.4],,,,
GC_00001315,K09013,Fe-S cluster assembly ATP-binding protein,sufC,ko:K09013,O,ABC transporter
GC_00001173,K07053,"3',5'-nucleoside bisphosphate phosphatase [EC:3.1.3.97]",,,E,DNA polymerase alpha chain like domain
GC_00003212,K13292,phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145],lgt,ko:K13292,M,Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GC_00000818,K03711,"Fur family transcriptional regulator, ferric uptake regulator",fur,ko:K03711,P,Belongs to the Fur family
GC_00000488,K06173,tRNA pseudouridine38-40 synthase [EC:5.4.99.12],truA,ko:K06173,J,"Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs"
GC_00000220,K01687,dihydroxy-acid dehydratase [EC:4.2.1.9],ilvD,ko:K01687,EG,Dehydratase family
GC_00000221,K00024,malate dehydrogenase [EC:1.1.1.37],mdh,ko:K00024,C,Catalyzes the reversible oxidation of malate to oxaloacetate
GC_00000047,K04487,cysteine desulfurase [EC:2.8.1.7],iscS,ko:K04487,E,"Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins"
GC_00000107,K01491,methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9],folD,ko:K01491,F,"Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate"
GC_00000106,K00342,NADH-quinone oxidoreductase subunit M [EC:7.1.1.2],nuoM-1,ko:K00342,C,Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
GC_00000360,K01710,"dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]",rfbB,ko:K01710,M,Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
GC_00039174,K04749,anti-sigma B factor antagonist,,ko:K04749,T,STAS domain
GC_00001033,K08679,UDP-glucuronate 4-epimerase [EC:5.1.3.6],capI,ko:K08679,M,Male sterility protein
GC_00000453,K07056,16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198],rsmI,ko:K07056,H,Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GC_00000635,K00075,UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98],murB,ko:K00075,M,Cell wall formation
GC_00000269,K03559,biopolymer transport protein ExbD,tolR,"ko:K03559,ko:K03560",U,Biopolymer transport protein ExbD/TolR
GC_00000268,K00012,UDPglucose 6-dehydrogenase [EC:1.1.1.22],,,,
GC_00000850,K15635,"2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]",apgM,ko:K15635,G,Metalloenzyme superfamily
GC_00035650,NA,NA,,,,
GC_00000195,K03979,GTPase [EC:3.6.5.-],obg,ko:K03979,S,"An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control"
GC_00000194,K02316,DNA primase [EC:2.7.7.101],dnaG,ko:K02316,L,RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication