TableS6 CommunicationGene,CommunicationModule TLR2,E1 GRIN2B,E1 IGF1,E1 IL22RA1,E1 KCNJ15,E1 EPOR,E2 ADORA2A,E2 CD274,E2 EBI3,E2 FLT3L,E2 GFRA3,E2 GRIA2,E2 GRIA3,E2 GRIN2C,E2 H2-M3,E2 H2-Q2,E2 ICOSL,E2 IL18BP,E2 IL6RA,E2 ITGA4,E2 LRP8,E2 NGFR,E2 NTRK1,E2 SSTR1,E2 SSTR2,E2 SSTR3,E2 VDR,E2 VSIR,E2 FGF9,E2 CCL28,E2 LAG3,E2 GFRA1,E2 CCRL2,E2 GRIN1,E2 FGF1,E2 GRIN3A,E2 GFRA4,E2 SST,E2 GM13305,E2 WNT3,E2 VLDLR,E2 ACVR2B,E3 ADIPOR1,E3 APLP2,E3 CAML,E3 CD44,E3 EDA2R,E3 IFNAR1,E3 IGF1R,E3 IL10RB,E3 NTF5,E3 PVR,E3 SDC1,E3 SRC,E3 TGFB3,E3 TGFBR2,E3 TNFRSF10B,E3 TNFRSF11B,E3 TNFRSF12A,E3 TRAF2,E3 WNT7A,E3 ACVR2A,E3 APP,E3 ERBB2,E3 HMGB1,E3 IFNGR1,E3 IFNGR2,E3 IGF2R,E3 IL2,E3 LRP6,E3 LTBR,E3 NECTIN2,E3 SDC4,E3 TGFBR1,E3 TNFRSF1B,E3 TNFSF9,E3 TRAF3,E3 CD47,E3 CSF1,E3 CXCL16,E3 IFNAR2,E3 IL3RA,E3 RAET1E,E3 TNF,E3 CD55,E3 S100A6,E3 MIF,E3 AGER,E4 CD34,E4 CXCL9,E4 EPOR,E4 FLT1,E4 FLT4,E4 FZD4,E4 H2-Q6,E4 H2-Q7,E4 IL1R1,E4 IL2RG,E4 IL6,E4 KDR,E4 RAET1D,E4 TNFSF10,E4 TNFSF8,E4 AR,E4 TNFRSF19,E4 CCL4,E4 CCL6,E4 CCL2,E4 CSF1R,E4 ACKR4,E5 CCL17,E5 FGF2,E5 H2-T24,E5 IL16,E5 IL17RB,E5 IL25,E5 INHBC,E5 KCNJ4,E5 NTRK2,E5 SORT1,E5 WNT5A,E5 IL1RAP,E5 IL10RB,E6 IL13RA1,E6 SORT1,E6 WNT5A,E6 ADIPOR2,E6 APP,E6 CANX,E6 CR1L,E6 ERBB2,E6 IFNGR1,E6 IL4RA,E6 INS2,E6 INSR,E6 LRP5,E6 LRP6,E6 LTBR,E6 NECTIN2,E6 SDC4,E6 TNFRSF1A,E6 TNFRSF1B,E6 TNFSF9,E6 CD47,E6 CSF2RA,E6 CD55,E6 CD14,E6 CX3CL1,E6 CXCL1,E6 H2-D1,E6 H2-K1,E6 H2-T22,E6 IL17RC,E6 IL1RN,E6 MET,E6 SDC2,E6 BDNF,E6 FGFR4,E6 H2-T23,E6 IFNLR1,E6 IL17RE,E6 IL18,E6 IL6ST,E6 LDLR,E6 LEPR,E6 LGALS9,E6 LIFR,E6 MYD88,E6 PORCN,E6 SORL1,E6 TLR4,E6 TNFRSF11A,E6 TNFRSF18,E6 TNFRSF21,E6 ADORA1,E6 APOE,E6 CCL20,E6 CCL27A,E6 CD74,E6 CXCL12,E6 CXCL5,E6 FGFR2,E6 FGFR3,E6 H2-AA,E6 H2-Q4,E6 IL15RA,E6 NRTN,E6 OSMR,E6 PF4,E6 SIRPA,E6 SPP1,E6 TNFSF12,E6 CXCL2,E6 APOB,E6 KCND1,E6 CXCL10,E6 FAS,E6 TGFB2,E6 IL7,E6 INHA,E6 TRAF5,E6 ARTN,E6 IL1A,E6 IL1F6,E6 CXCL3,E6 IL5RA,E6 IL33,E6 LTB,E6 CEACAM1,E6 CSF3,E6 FLT4,E7 ACKR3,E7 ACVR2B,E7 ADGRE5,E7 ADRB2,E7 APLP2,E7 AR,E7 CAML,E7 CCL25,E7 CD40,E7 CD44,E7 CD53,E7 CD80,E7 CNTFR,E7 CSF2,E7 CXCR4,E7 EGFR,E7 FGFR1,E7 GFRA2,E7 HAS2,E7 HAVCR2,E7 IFNAR1,E7 IGF1R,E7 IL11,E7 IL15,E7 IL17RA,E7 IL18R1,E7 IL18RAP,E7 IL23A,E7 IL24,E7 IL34,E7 INHBA,E7 INHBB,E7 ITGB1,E7 KLRC1,E7 LIF,E7 MMP9,E7 NGF,E7 NTF5,E7 PDCD1LG2,E7 PDGFA,E7 PDGFB,E7 PTK2,E7 PVR,E7 SDC1,E7 SRC,E7 TGFB1,E7 TGFBR2,E7 TNFRSF9,E7 TNFSF4,E7 TRAF1,E7 TRAF2,E7 VEGFA,E7 VEGFC,E7 WNT7A,E7 CSF1,E7 GABBR1,E7 HAS3,E7 CX3CR1,E7 PDGFRA,E7 RET,E7 CCL7,E7 GHR,E7 INS1,E7 PDGFRB,E7 WNT2,E7 IL1RL1,E7 TNFRSF8,E7 CCR2,T8 CSF2,T8 TNFRSF25,T8 ACVR2A,T8 APLP2,T8 AR,T8 CCL1,T8 CCL17,T8 CCRL2,T8 CXCL10,T8 GRIN2D,T8 ICOSL,T8 IL17RB,T8 IL1RL1,T8 IL2,T8 IL2RA,T8 IL2RG,T8 IL4,T8 IL6,T8 IL9R,T8 LIF,T8 SDC4,T8 SORL1,T8 TGFB1,T8 TNFRSF11A,T8 TNFSF11,T8 TRAF3,T8 H2-Q6,T8 IL1RAP,T8 PDCD1LG2,T8 CCR8,T8 EBI3,T8 IL1RN,T8 SRC,T8 TNFRSF18,T8 CSF1,T8 IL10RA,T8 IGF1,T8 IL15RA,T8 FZD4,T8 CCR9,T8 CCR2,T9 CD44,T9 CXCR6,T9 GABBR1,T9 ICOS,T9 IGF1R,T9 IL12RB1,T9 IL17A,T9 IL17RC,T9 IL17RE,T9 IL18R1,T9 IL1R1,T9 IL23R,T9 IL7R,T9 RET,T9 S100A6,T9 SDC1,T9 TNF,T9 TNFRSF21,T9 TNFRSF25,T9 TNFSF14,T9 VDR,T9 CCR6,T9 CCRL2,T9 H2-AA,T9 IL22,T9 LTA,T9 LTB,T9 TNFSF11,T9 CANX,T9 SELPLG,T9 TNFRSF1A,T9 CCL22,T9 CD96,T9 IFNGR1,T9 IL27RA,T9 PVRIG,T9 VSIR,T9 IL2RA,T10 IFNAR1,T10 ITGA4,T10 ADORA2A,T10 CCL7,T10 CCR1,T10 CCR4,T10 CD274,T10 CD5,T10 CXCR4,T10 HAVCR2,T10 IL18,T10 IL1R2,T10 IL3RA,T10 PDCD1LG2,T10 PDGFB,T10 TNFRSF13B,T10 TNFRSF1B,T10 TRAF1,T10 TRAF2,T10 EBI3,T10 TNFRSF18,T10 CD40,T10 TNFRSF9,T10 CCR3,T10 CD80,T10 CTLA4,T10 IL10,T10 KLRG1,T10 MMP9,T10 PDCD1,T10 TNFRSF4,T10 CD4,T10 TIGIT,T10 TNFRSF8,T10 TGFBR1,T10 TNFSF8,T10 CD28,T10 CD40LG,T10 H2-Q4,T11 H2-T22,T11 IL16,T11 TRAF5,T11 CD53,T11 IL4RA,T11 MYD88,T11 APP,T11 BTLA,T11 CCL2,T11 CCL25,T11 CCL6,T11 CCR7,T11 CD27,T11 CD55,T11 H2-T24,T11 IL17RA,T11 IL6RA,T11 IL6ST,T11 PF4,T11 SELL,T11 SPP1,T11 TNFRSF12A,T11 VEGFA,T11 CXCR5,T11 FAS,T11 LDLR,T11 NTRK3,T11 PVR,T11 LRP6,T11 CCL24,T11 IL1RL2,T11 CSF2RB,T11 CSF3R,T11 IL15,T12 LRP5,T12 SDC2,T12 PDGFA,T12 CX3CL1,T12 INSR,T12 TLR4,T12 ADIPOR2,T13 ADIPOR1,T13 CANX,T13 CCL27A,T13 CD47,T13 CR1L,T13 CSF1R,T13 H2-M3,T13 HMGB1,T13 IL16,T13 IL1B,T13 LGALS9,T13 MIF,T13 CAML,T13 CCL12,T13 CCL7,T13 CD14,T13 CD70,T13 CXCL1,T13 CXCL3,T13 FLT3L,T13 IL1A,T13 LRP8,T13 MYD88,T13 OSM,T13 TGFBR2,T13 CXCL16,T13 ULBP1,T13 SIRPA,T13 TGFB3,T13 TLR2,T13 IL18BP,T13 CCL8,T13 PTK2,T13 CSF2RA,T13 H2-AA,T14 IL2,T14 SORL1,T14 CCL4,T14 FASL,T14 XCL1,T14 ADGRE5,T14 ADIPOR1,T14 CCL27A,T14 CCL3,T14 CCL5,T14 CCR5,T14 CD160,T14 CD226,T14 CD47,T14 CSF1R,T14 CX3CR1,T14 CXCR3,T14 GZMB,T14 H2-M3,T14 H2-Q6,T14 H2-Q7,T14 H2-T23,T14 HMGB1,T14 IFNAR1,T14 IFNAR2,T14 IFNG,T14 IL10RB,T14 IL12RB2,T14 IL18RAP,T14 IL1B,T14 IL21R,T14 IL2RB,T14 ITGB1,T14 KLRB1C,T14 KLRC1,T14 KLRC2,T14 KLRD1,T14 KLRK1,T14 LAG3,T14 LGALS9,T14 SELPLG,T14 TNFRSF1A,T14 TNFSF10,T14 TNFSF12,T14 ADORA2A,T14 CCL22,T14 CD96,T14 FLT3L,T14 H2-D1,T14 IFNGR1,T14 TGFBR2,T14 TNFRSF1B,T14 TNFSF9,T14 CXCL16,T14 H2-K1,T14 TNFSF13B,T14 NECTIN2,M15 CD40,M15 CD47,M15 H2-Q7,M15 IL2RG,M15 ITGA4,M15 TNFSF9,M15 TRAF2,M15 CD274,M15 TRAF1,M15 IL27RA,M15 IL12B,M15 ADORA2A,M15 AR,M15 CCL17,M15 CCL22,M15 CCL5,M15 CCR7,M15 CD70,M15 CX3CL1,M15 EGF,M15 GRIA3,M15 H2-Q6,M15 ICOS,M15 IL15RA,M15 IL2RA,M15 IL7R,M15 IL9R,M15 KLRK1,M15 LRP8,M15 LTA,M15 PDCD1LG2,M15 TNFRSF18,M15 TNFRSF4,M15 TNFRSF9,M15 TNFSF11,M15 TNFSF4,M15 KCND1,M15 CCR6,M15 FLT3,M15 CXCL9,M15 CXCR5,M15 CD160,M15 CD28,M15 IL15,M15 CD47,M16 FLT3L,M16 IL2RG,M16 TNFSF9,M16 TRAF1,M16 CD34,M16 ICOS,M16 KLRK1,M16 TNFRSF18,M16 CCR6,M16 FLT3,M16 KLRD1,M16 BTLA,M16 CD226,M16 CD96,M16 CXCR3,M16 FGFR1,M16 GABBR1,M16 GFRA2,M16 IL18R1,M16 KLRC2,M16 LTB,M16 NGFR,M16 PTK2,M16 TNFRSF10B,M16 XCR1,M16 IL1RL1,M16 IL1R1,M16 FLT1,M16 IL1RAP,M17 CCR1,M17 FAS,M17 SORL1,M17 TNFRSF1B,M17 TNFSF14,M17 CCL3,M17 CCRL2,M17 CD14,M17 IL1A,M17 LTB,M17 CSF1,M17 CSF3R,M17 IL1B,M17 IL23A,M17 MMP9,M17 CXCL3,M17 CXCR2,M17 IGF1R,M17 IL18RAP,M17 IL1F9,M17 IL1R2,M17 IL1RN,M17 CCR3,M17 CSF3,M17 SELL,M17 SELP,M17 ACKR3,M18 CCL24,M18 CD44,M18 IL17RA,M18 IL6,M18 INHBA,M18 LIF,M18 MET,M18 RAET1E,M18 S100A6,M18 TLR4,M18 VEGFA,M18 ADGRE5,M18 CCR1,M18 CD274,M18 CD80,M18 TNFRSF1B,M18 IGF2R,M18 RAET1D,M18 CXCL3,M18 IGF1R,M18 IL7,M18 CCL2,M19 CXCL1,M19 LGALS9,M19 SDC4,M19 CR1L,M19 CSF2RA,M19 H2-K1,M19 H2-M3,M19 H2-T22,M19 H2-T23,M19 HMGB1,M19 IFNGR1,M19 SELPLG,M19 TGFB1,M19 TNFRSF13B,M19 ACVR2B,M19 CCL12,M19 CCL27A,M19 CCL7,M19 CCL8,M19 CCR5,M19 CD4,M19 CSF1R,M19 CX3CR1,M19 CXCL16,M19 FZD4,M19 H2-AA,M19 H2-Q4,M19 HGF,M19 IFNAR1,M19 IFNGR2,M19 IGF1,M19 IL10RA,M19 IL10RB,M19 IL16,M19 IL18BP,M19 IL1RL2,M19 IL21R,M19 IL6RA,M19 KCNJ10,M19 LAG3,M19 LIFR,M19 LRP6,M19 PDGFA,M19 PDGFB,M19 PF4,M19 PORCN,M19 SIRPA,M19 SRC,M19 TGFBR1,M19 TGFBR2,M19 TNFRSF11A,M19 TNFRSF21,M19 TNFSF12,M19 TNFSF8,M19 VSIR,M19 ADIPOR1,M19 ADRB2,M19 CXCL10,M19 CXCR4,M19 EBI3,M19 H2-D1,M19 HAVCR2,M19 IFNAR2,M19 IFNB1,M19 IL10,M19 IL18,M19 IL2,M19 IL27,M19 TGFB3,M19 TLR2,M19 TNF,M19 TNFRSF12A,M19 TNFSF13B,M19 INSR,M19 KDR,M19 ADORA1,M19 CCL4,M19 H2-M2,M19 ICOSL,M19 IL17A,M19 PDCD1,M19 XCL1,M19 TNFRSF17,M19 TNFSF10,M19 FGF2,M19 CXCL12,M19 KCNA3,M19 CXCR6,M19 ADIPOR2,M20 APLP2,M20 APP,M20 CAML,M20 CANX,M20 CCL6,M20 CCR2,M20 CSF2RB,M20 CXCL1,M20 ESR1,M20 IL13RA1,M20 IL3RA,M20 IL4RA,M20 IL6ST,M20 ITGB1,M20 LEPR,M20 LGALS9,M20 LRP5,M20 LTBR,M20 MIF,M20 NECTIN2,M20 OSM,M20 PVR,M20 SDC1,M20 SORT1,M20 SPP1,M20 TNFRSF1A,M20 VDR,M20 ACVR2A,M20 CD53,M20 CEACAM1,M20 CR1L,M20 CSF2RA,M20 H2-T22,M20 HMGB1,M20 IL2RG,M20 ITGA4,M20 LDLR,M20 MYD88,M20 TGFB1,M20 CCR5,M20 IL1RL2,M20 LRP6,M20 SIRPA,M20 SRC,M20 TNFRSF21,M20 TNFSF8,M20 CCL25,M20 GM13305,M20 IL12RB2,M20 KLRB1C,M20 PVRIG,M20 TNFRSF14,M20 TRAF3,M20 TRAF5,M20 PDGFRB,M20 SDC2,M20 CCR9,M21 IL12A,M21 IL17RB,M21 IL33,M21 NRTN,M21 CD55,M21 CD27,M21 CD5,M21 IL2RB,M21 GZMB,M21 IL4,M21 CD27,B22 ADGRE5,B23 ADIPOR1,B23 ADIPOR2,B23 CAML,B23 CANX,B23 CCL17,B23 CCL5,B23 CCR1,B23 CCR5,B23 CCRL2,B23 CD274,B23 CD44,B23 CD47,B23 CD80,B23 CSF2RB,B23 CXCL10,B23 CXCR3,B23 EBI3,B23 H2-M3,B23 H2-Q7,B23 H2-T22,B23 H2-T23,B23 H2-T24,B23 HMGB1,B23 IL10,B23 IL18,B23 IL18RAP,B23 IL1R2,B23 IL2,B23 IL2RB,B23 ITGA4,B23 ITGB1,B23 LAG3,B23 LDLR,B23 MIF,B23 MYD88,B23 S100A6,B23 SELPLG,B23 TNFRSF13B,B23 TNFSF9,B23 TRAF2,B23 TRAF3,B23 APP,B23 CCL1,B23 CCL12,B23 CCL2,B23 CCL24,B23 CCL3,B23 CCL4,B23 CCL6,B23 CCL7,B23 CCL8,B23 CCR10,B23 CCR9,B23 CD14,B23 CD28,B23 CD4,B23 CR1L,B23 CSF1R,B23 CSF2RA,B23 CTLA4,B23 CX3CR1,B23 CXCL1,B23 CXCL16,B23 CXCL3,B23 CXCR6,B23 EGF,B23 IFNAR2,B23 IGF1,B23 IGF1R,B23 IGF2R,B23 IL15,B23 IL1B,B23 IL1RN,B23 IL2RA,B23 IL3RA,B23 KCNA3,B23 OSM,B23 PF4,B23 SDC1,B23 SIRPA,B23 SRC,B23 TGFBR1,B23 TLR2,B23 TLR4,B23 TNF,B23 TNFRSF12A,B23 TNFRSF17,B23 TNFRSF4,B23 TNFSF12,B23 VEGFA,B23 VSIR,B23 CCR2,B23 CD96,B23 CSF3R,B23 H2-K1,B23 IL6RA,B23 KLRD1,B23 LGALS9,B23 TNFRSF18,B23 TNFRSF1A,B23 XCL1,B23 ADORA2A,B23 CCL22,B23 CCL27A,B23 CD160,B23 FAS,B23 HAVCR2,B23 IFNGR1,B23 IL13RA1,B23 IL15RA,B23 IL16,B23 IL17A,B23 IL1A,B23 IL6,B23 PDCD1,B23 SPP1,B23 IL7R,B23 PDGFA,B23 LTBR,B23 H2-D1,B24 ADRB2,B24 CCR6,B24 CD55,B24 CXCR4,B24 ICOSL,B24 IL10RA,B24 IL12A,B24 IL2RG,B24 SELL,B24 TRAF5,B24 BTLA,B24 CXCR5,B24 H2-AA,B24 H2-Q4,B24 IL21R,B24 IL27RA,B24 LTB,B24 SORL1,B24 TGFBR2,B24 H2-Q6,B24 CCR7,B24 IL4RA,B24 PDCD1LG2,B24 IL2,B25 TRAF2,B25 CD160,B25 FAS,B25 FLT3,B25 HAVCR2,B25 IL16,B25 IL17RA,B25 TNFRSF9,B25 TRAF1,B25 IFNGR2,B25 LTA,B25 CD40,B25 FLT3L,B25 CD5,B25 ICOS,B25 PTK2,B25 TRAF5,B25 TNFRSF1B,B25 EBI3,B26 IL2,B26 CD53,B26 H2-K1,B26 IFNAR1,B26 LGALS9,B26 SDC4,B26 TGFB1,B26 APLP2,B26 IFNGR2,B26 CCR6,B26 IL9R,B26 LRP6,B26 PVR,B26 CCL25,B26 CD40,B26 CEACAM1,B26 IL10RB,B26 INSR,B26