geneID,symbol,baseMean,log2FoldChange,lfcSE,stat,pvalue,padj,stage,type,URL,description
Cluster-741.13,RGP1_PEA,839.042668690525,-1.10264372190041,0.323768578527181,-3.40565389920271,0.00066005798994073,0.0339800320727995,early,sup,https://www.uniprot.org/uniprot/O04300,function:Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides (By similarity). Was initially shown to possess an autoglycosylating activity which is dependent on the presence of UDP-glucose and manganese (PubMed:9207152).|catalytic activity:UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose|cofactor:Mn(2+)|cofactor:Mg(2+)|activity regulation:Inhibited by inhibitor protein (IP) which may be a form of sucrose synthase.|subunit:Homopentamer or homohexamer.|subcellular location:Cell wall-associated; with highest concentrations on plasmodesmata. Also located in the Golgi apparatus.|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Cell junction|subcellular location:Plasmodesma|subcellular location:Golgi apparatus|domain:The conserved DXD motif is involved in enzyme activity.|PTM:Reversibly glycosylated by UDP-glucose; UDP-xylose and UDP-galactose; but not UDP-mannose.|similarity:Belongs to the RGP family.
Cluster-5155.2,ADS3_ARATH,111.828705399183,-4.68714914476261,1.02380709720187,-4.57815652731153,4.69091631065038E-06,0.00072992777981882,early,sup,https://www.uniprot.org/uniprot/Q9LVZ4,function:Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7;10;13-trienoic acid (16:3(7Z;10Z;13Z)); the major functional components of thylakoid membranes (PubMed:15579662; PubMed:16666902; PubMed:15240892). Required for chloroplast biogenesis at low temperature (PubMed:16668849). Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).|catalytic activity:a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]|cofactor:Fe(2+)|pathway:Lipid metabolism; oxylipin biosynthesis.|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Plastid|subcellular location:Chloroplast membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in young leaves. Low expression in roots.|domain:The histidine box domains are involved in binding the catalytic metal ions.|miscellaneous:Substrate specificity shifts from delta-7 to delta-9 desaturation when the protein is retargeted to the cytoplasm.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-5155.7,ADS3_ARATH,72.577544615312,-4.47054969419136,1.00533228890241,-4.44683786996651,8.71435578763478E-06,0.00122454483215835,early,sup,https://www.uniprot.org/uniprot/Q9LVZ4,function:Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7;10;13-trienoic acid (16:3(7Z;10Z;13Z)); the major functional components of thylakoid membranes (PubMed:15579662; PubMed:16666902; PubMed:15240892). Required for chloroplast biogenesis at low temperature (PubMed:16668849). Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).|catalytic activity:a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]|cofactor:Fe(2+)|pathway:Lipid metabolism; oxylipin biosynthesis.|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Plastid|subcellular location:Chloroplast membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in young leaves. Low expression in roots.|domain:The histidine box domains are involved in binding the catalytic metal ions.|miscellaneous:Substrate specificity shifts from delta-7 to delta-9 desaturation when the protein is retargeted to the cytoplasm.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-14681.1,86A22_PETHY,616.632101052317,-3.83952029832436,1.19107275444426,-3.22358166954784,0.00126598192768145,0.0531549175154074,early,sup,https://www.uniprot.org/uniprot/B3RFJ6,function:Fatty acyl-CoA omega-hydroxylase essential for the production of omega-hydroxy fatty acids and the biosynthesis of triacylglycerol-/diacylglycerol-based estolide polyesters in the stigma. Substrate preference is 16:0-CoA > 18:1-CoA > 18:0-CoA.|catalytic activity:(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]|catalytic activity:(9Z;12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z;12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]|cofactor:heme|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Mostly expressed in the developing stigma of floral buds. Weakly detected in leaves; stems and flowers.|similarity:Belongs to the cytochrome P450 family.
Cluster-16404.1,PTR34_ARATH,960.870547334325,-1.36768863621441,0.319322832543044,-4.2830906431661,1.84315039976854E-05,0.00215101899620445,early,sup,https://www.uniprot.org/uniprot/Q0WT12,function:Involved in (+) and (-)-abscisic acid transport (ABA) and in gibberellin import.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in siliques and flowers.|similarity:Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Cluster-23404.0,SEC_ARATH,933.923701263943,-1.16527822158652,0.179469510424497,-6.49290355130686,8.41975968413729E-11,3.80159051181163E-08,early,sup,https://www.uniprot.org/uniprot/Q9M8Y0,function:O-linked N-acetylglucosamine transferase (OGT) that mediates O-glycosylation of capsid protein (CP) of virus in case of infection by Plum pox virus (PubMed:16014901). OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine (PubMed:16014901). Probably acts by adding O-linked sugars to yet unknown proteins. Its OGT activity has been proved in vitro but not in vivo (PubMed:16014901). Required with SPY for gamete and seed development (PubMed:16014901). Activates ATX1 through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone epigenetic modification at FLC locus; thus preventing premature flowering (PubMed:30150325).|catalytic activity:L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP|catalytic activity:L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP|pathway:Protein modification; protein glycosylation.|subunit:Interacts with TCP14 and TCP15 (PubMed:22267487). Interacts with ATX1 (PubMed:30150325).|disruption phenotype:Early flowering phenotype due to reduced histone H3 'Lys-4' trimethylation (H3K4me3) of FLC thus leading to lower FLC expression.|similarity:Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Cluster-23948.0,Y3209_ORYSJ,9.81835591448484,-3.22282346337896,0.649897871845463,-4.95896909806361,7.08682377646593E-07,0.00013277911595335,early,sup,https://www.uniprot.org/uniprot/A0A0P0VSB0,subcellular location:Nucleus
Cluster-25860.0,HBP1A_WHEAT,95.0139200591584,-1.16928911315464,0.26720817659722,-4.3759481017573,1.20905781480078E-05,0.00158570811120206,early,sup,https://www.uniprot.org/uniprot/P23922,function:Binds to the hexamer motif 5'-ACGTCA-3' of histone gene promoters.|subunit:Binds DNA as a dimer.|subcellular location:Nucleus|similarity:Belongs to the bZIP family.
Cluster-27569.0,AMO_ARATH,91.8694206941025,-1.15153441870231,0.291731935571564,-3.94723469834116,7.90590476719655E-05,0.00691555993166291,early,sup,https://www.uniprot.org/uniprot/Q9SI68,catalytic activity:an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)|cofactor:Binds 1 copper ion per subunit (By similarity). Can also use zinc ion as cofactor (By similarity).|cofactor:Cu cation|cofactor:Zn(2+)|cofactor:Contains 1 topaquinone per subunit.|cofactor:L-topaquinone|cofactor:Binds 1 Mn(2+) ion per subunit.|cofactor:Mn(2+)|subunit:Homodimer.|PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.|similarity:Belongs to the copper/topaquinone oxidase family.|sequence caution:The predicted gene has been split into 3 genes: At1g62810; At1g62820 and At1g62830.
Cluster-27569.1,AMO_ARATH,43.1069865616264,-1.405903565481,0.442111785770231,-3.17997305371918,0.0014728874780601,0.059048423465402,early,sup,https://www.uniprot.org/uniprot/Q9SI68,catalytic activity:an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)|cofactor:Binds 1 copper ion per subunit (By similarity). Can also use zinc ion as cofactor (By similarity).|cofactor:Cu cation|cofactor:Zn(2+)|cofactor:Contains 1 topaquinone per subunit.|cofactor:L-topaquinone|cofactor:Binds 1 Mn(2+) ion per subunit.|cofactor:Mn(2+)|subunit:Homodimer.|PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.|similarity:Belongs to the copper/topaquinone oxidase family.|sequence caution:The predicted gene has been split into 3 genes: At1g62810; At1g62820 and At1g62830.
Cluster-28922.0,4CGT_ANTMA,53.4240585164755,-1.73309410090694,0.481195908491266,-3.60163931223117,0.00031621689275372,0.0200673863138782,early,sup,https://www.uniprot.org/uniprot/A6YS03,function:Glycosyltransferase involved in the biosynthesis of aurones; plant flavonoids that provide yellow coloration to flowers.|catalytic activity:2';4;4';6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2';4;4';6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP|catalytic activity:2';3;4;4';6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2';3;4;4';6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP|subcellular location:Cytoplasm|tissue specificity:Expressed in petals. Not detected in stems and leaves.|similarity:Belongs to the UDP-glycosyltransferase family.
Cluster-29665.0,RBOHA_SOLTU,92.9803942166768,-1.5326438505558,0.409125194632587,-3.74614878443793,0.00017957011351204,0.0129264350431318,early,sup,https://www.uniprot.org/uniprot/Q948U0,function:Calcium-dependent NADPH oxidase that generates superoxide. Involved in the rapid and transient phase I oxidative burst induced by pathogen infection.|subunit:Monomer and homodimer.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|induction:Expressed constitutively. Not induced by fungal elicitor.|PTM:Phosphorylated by CPK.|similarity:Belongs to the RBOH (TC 5.B.1.3) family.
Cluster-34063.0,ATAD1_RAT,43.5165729148201,-1.53208995730733,0.362674363190525,-4.22442309908315,2.39553631537735E-05,0.00272635790074889,early,sup,https://www.uniprot.org/uniprot/B3STU2,function:Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR); thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).|catalytic activity:[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate|biophysicochemical properties:43.4 mM for ATP|biophysicochemical properties:11.0 nM/min/mg enzyme|subcellular location:Mitochondrion outer membrane|subcellular location:Single-pass membrane protein|subcellular location:Peroxisome membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell junction|subcellular location:Synapse|subcellular location:Postsynaptic cell membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the AAA ATPase family. MSP1 subfamily.|sequence caution:Truncated N-terminus.
Cluster-34818.0,C71A1_PERAE,121.305910434871,-2.20334543982069,0.364928767848083,-6.03774115374188,1.5628649654909E-09,5.59018530903252E-07,early,sup,https://www.uniprot.org/uniprot/P24465,function:Involved in the metabolism of compounds associated with the development of flavor in the ripening fruit process; possibly by acting as trans-cinnamic acid 4-hydrolase.|cofactor:heme|subcellular location:Microsome membrane|subcellular location:Single-pass membrane protein|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|tissue specificity:Mesocarp.|developmental stage:In ripening fruit.|induction:By ethylene.|similarity:Belongs to the cytochrome P450 family.
Cluster-34838.0,M3K17_ARATH,117.147346443156,-1.57411741913289,0.301358047255332,-5.22341259332354,1.75655398830905E-07,3.66507651106121E-05,early,sup,https://www.uniprot.org/uniprot/O80888,function:Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Triggers MPK7 activation in a MKK3-dependent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subunit:Binds to MKK3.|subcellular location:Nucleus|induction:Strongly induced by abscisic acid (ABA). Accumulates in response to osmotic stresses (e.g. mannitol and NaCl).|disruption phenotype:In the double mutant map3k17 map3k18; impaired MPK7 activation mediated by abscisic acid (ABA).|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-35029.0,PIRL3_ARATH,48.5872614853791,-1.00851796714186,0.235730337418111,-4.27826973052291,1.88351699987159E-05,0.00217965652144803,early,sup,https://www.uniprot.org/uniprot/Q9LPV2,tissue specificity:Widely expressed.|similarity:Belongs to the SHOC2 family.
Cluster-35717.0,NPY2_ARATH,121.496825340886,-1.16975202093486,0.210710399278466,-5.55146791492226,2.83280714108061E-08,7.9613443142492E-06,early,sup,https://www.uniprot.org/uniprot/O80970,function:May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses.|pathway:Protein modification; protein ubiquitination.|tissue specificity:Specifically expressed in the hypophysis and the root meristems in the embryos. Highly expressed in primary root tips.|similarity:Belongs to the NPH3 family.
Cluster-36494.0,NA,17.621170846677,-1.17940933698652,0.373148662671136,-3.16069560197234,0.00157392887481177,0.0622832601581404,early,sup,NA,NA
Cluster-39025.0,SYT2_ARATH,20.9343355432793,-2.31898135588267,0.607059373844483,-3.82002396437214,0.00013343870863192,0.010208802536501,early,sup,https://www.uniprot.org/uniprot/Q9LNT5,function:May play an important role in regulating an unconventional protein trafficking from the cytosol to the extracellular matrix.|cofactor:Ca(2+)|subcellular location:Golgi apparatus membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the synaptotagmin family.
Cluster-39620.0,USPAL_ARATH,70.0587816023838,-2.92772677768691,0.670761808361718,-4.36477858636234,1.27251583238232E-05,0.00162257551182749,early,sup,https://www.uniprot.org/uniprot/Q9SSA2,subunit:Homohexamer.|similarity:Belongs to the universal stress protein A family.
Cluster-39966.0,TCP9_ARATH,191.023525425662,-1.61825709730458,0.375198402711494,-4.3130703265518,1.61002876150755E-05,0.00195345427971105,early,sup,https://www.uniprot.org/uniprot/O64647,subunit:Interacts with SPL.|subcellular location:Nucleus|tissue specificity:Expressed in archespores; pollen mother cell; ovule primordia and megaspore mother cells.
Cluster-40329.0,DOF37_ARATH,27.5896982845071,-1.90104102536514,0.437176625338433,-4.34845075235548,1.37102596378203E-05,0.00170863335269162,early,sup,https://www.uniprot.org/uniprot/Q9SAF9,function:Transcription factor specifically involved in the maternal control of seed germination. Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence. May ensure the inactivity of a component that would be activated to trigger germination as a consequence of red light perception.|subcellular location:Nucleus|alternative products:Q43385-1|alternative products:1|alternative products:Q43385-2|alternative products:2|tissue specificity:Expressed in the phloem of the mother plant; including in roots; stem; leaves and flowers; but not present in the seed and embryo. In maturing siliques; found all through the funiculus connecting the placenta to the ovule; but not in the ovule.|developmental stage:Turned off in siliques when they reached full maturation. Not expressed in developing or mature embryos.|miscellaneous:The regulatory role of DOF3.7/DAG1 appears to be opposite to that of DOF2.5/DAG2. Both zinc finger proteins may act on a maternal switch that controls seed germination; possibly by regulating the same gene(s).
Cluster-41171.0,RPP13_ARATH,33.7761995024452,-1.49948573505334,0.304205918063669,-4.92918002581232,8.25754576466647E-07,0.00015161955030029,early,sup,https://www.uniprot.org/uniprot/Q9SNC5,domain:The LRR repeats probably act as specificity determinant of pathogen recognition.|miscellaneous:In cv. Nd-1; it confers resistance to Mask-9; Aswa1; Edco1; Emco5 and Goco5 loci from Hyaloperonospora parasitica. In cv. Columbia; it confers resistance to Wela3 locus from Hyaloperonospora parasitica. In cv. RLD; it confers resistance to all of these loci.|similarity:Belongs to the disease resistance NB-LRR family. RPP13 subfamily.|online information:Functional and comparative genomics of disease resistance gene homologs
Cluster-42710.0,NA,8.66835018520678,-2.61965050253935,0.853393915350221,-3.06968500175476,0.00214284645415661,0.0774518071396079,early,sup,NA,NA
Cluster-42792.0,86A22_PETHY,5210.46292201067,-1.10515889921616,0.359765228747899,-3.07188914021089,0.00212708707445249,0.0770724238223878,early,sup,https://www.uniprot.org/uniprot/B3RFJ6,function:Fatty acyl-CoA omega-hydroxylase essential for the production of omega-hydroxy fatty acids and the biosynthesis of triacylglycerol-/diacylglycerol-based estolide polyesters in the stigma. Substrate preference is 16:0-CoA > 18:1-CoA > 18:0-CoA.|catalytic activity:(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]|catalytic activity:(9Z;12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z;12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]|cofactor:heme|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Mostly expressed in the developing stigma of floral buds. Weakly detected in leaves; stems and flowers.|similarity:Belongs to the cytochrome P450 family.
Cluster-45067.0,BSP_BOSSE,118.813608378428,-1.73723144472955,0.476725856580164,-3.6440889889878,0.00026834057221799,0.0176809474641815,early,sup,https://www.uniprot.org/uniprot/C0HJG8,function:Metalloprotease; digests gelatin and azocasein (in vitro).|cofactor:a divalent metal cation|activity regulation:Inhibited by EDTA.|PTM:Glycosylated.
Cluster-45227.0,IBL1_ARATH,249.22942451548,-2.53636207012786,0.428991884515954,-5.91237774343849,3.3720411776555E-09,1.07991579203474E-06,early,sup,https://www.uniprot.org/uniprot/Q9M0B9,function:Functions redundandly with IBH1/BHLH158 in a regulation node known as the incoherent feed-forward loop (FFL). Acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling.|subcellular location:Nucleus|disruption phenotype:No visible phenotype.|miscellaneous:Plants over-expressing IBL1 are dwarf with round-shaped; dark-green leaves and short petioles.|similarity:Belongs to the bHLH protein family.
Cluster-46461.0,IQD31_ARATH,18.6249388596037,-2.70863559733756,0.670897089626359,-4.03733395064521,5.40620847772672E-05,0.00524288006667427,early,sup,https://www.uniprot.org/uniprot/Q9SSF5,subunit:Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.|subcellular location:Associates to cortical microtubules (MTs).|subcellular location:Nucleus|subcellular location:Nucleus envelope|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Cell membrane|similarity:Belongs to the IQD family.
Cluster-48008.1,DR100_ARATH,628.176660051465,-2.95346570640248,0.936252924225267,-3.15455966009016,0.00160740509906646,0.0630141866183339,early,sup,https://www.uniprot.org/uniprot/Q9LHK0,function:This protein is able to complement bacterial recA mutations; but its native function in the plant is not known.
Cluster-48055.0,DOF46_ARATH,58.3650288535905,-2.09567584402882,0.297050050973448,-7.05495870867951,1.72651983860622E-12,1.18879523487231E-09,early,sup,https://www.uniprot.org/uniprot/Q9SU49,function:Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.|subcellular location:Nucleus|alternative products:Q8LAP8-1|alternative products:1|alternative products:Q8LAP8-2|alternative products:2|tissue specificity:Accumulates in the stele.|developmental stage:Expressed at preprocambial stages first in wide domains; and later confined to sites of vein development.|miscellaneous:Isoform 2|miscellaneous:May be due to an intron retention.
Cluster-49973.0,AP2L1_ARATH,131.577180318377,-1.10678777189542,0.370210257489019,-2.98961941087829,0.00279325243834176,0.0932183946838762,early,sup,https://www.uniprot.org/uniprot/Q9S9M9,function:Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).|subcellular location:Nucleus|alternative products:Q94AN4-1|alternative products:1|alternative products:Q94AN4-2|alternative products:2|similarity:Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
Cluster-50416.0,FAO4A_ARATH,306.620510794797,-3.06032163036634,0.344331616747378,-8.88771603164043,6.23778571387741E-19,8.59005470658058E-16,early,sup,https://www.uniprot.org/uniprot/O65709,function:Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.|catalytic activity:a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2|subcellular location:Membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the GMC oxidoreductase family.
Cluster-50537.0,ALD1_ARATH,51.9949406058059,-1.3357813188336,0.380553798215711,-3.51009850669374,0.00044794071427201,0.0253330249537571,early,sup,https://www.uniprot.org/uniprot/Q93ZH8,function:Aminotransferase involved in local and systemic acquired resistance (SAR) to the bacterial pathogen P.syringae. Required for salicylic acid (SA) and camalexin accumulation upon pathogen infection. Possesses aminotransferase activity in vitro and may generate amino-acid-derived defense signals in vivo. May be involved in ethylene-induced senescence signaling. Involved in the biosynthesis of pipecolate (Pip); a metabolite that orchestrates defense amplification; positive regulation of SA biosynthesis; and priming to guarantee effective local resistance induction and the establishment of SAR (PubMed:23221596; PubMed:27758894). Converts lysine to alpha-keto-epsilon-aminocaproate; which then can spontaneously cyclize to form delta-(1)-piperideine-2-carboxylate (P2C). P2C is converted to Pip by SARD4 (PubMed:27758894). May produce non-Pip metabolites that play roles in immunity. Involved in the synthesis of distinct metabolite signals that affect basal and early defenses; and later defense responses (PubMed:25372120).|cofactor:Binds 1 pyridoxal phosphate per subunit.|cofactor:pyridoxal 5'-phosphate|subcellular location:Plastid|subcellular location:Chloroplast|tissue specificity:Highly expressed in senescing leaves; flowers; siliques and seeds.|induction:By ozone; benzothiadiazole (BTH) and infection with the bacterial pathogen P.syringae pv. maculicola. Down-regulated by nitric oxide.|disruption phenotype:No visible phenotype under normal growth conditions; but during infection with virulent strain of P.syringae; mutant plants have reduced levels of SA and camalexin; and show increased susceptibility to pathogen. Leaves show decreased ethylene-induced senescence.|miscellaneous:Treatment with exogenous pipecolate (Pip) enhances disease resistance to Pseudomonas syringae pv. maculicola (PubMed:23221596). Plants over-expressing ALD1 exhibit resistance to Pseudomonas syringae pv. maculicola (PubMed:25372120).|similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Cluster-52034.0,P2C52_ARATH,250.74876550387,-1.06461173961601,0.319721848491203,-3.32980603183677,0.00086906502378834,0.0409158784362026,early,sup,https://www.uniprot.org/uniprot/Q8GY60,catalytic activity:H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate|catalytic activity:H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate|cofactor:Binds 2 magnesium or manganese ions per subunit.|cofactor:Mg(2+)|cofactor:Mn(2+)|similarity:Belongs to the PP2C family.
Cluster-52771.0,NA,12.4170521982218,-2.80916589586073,0.94342457014511,-2.97762638875162,0.00290489847385627,0.0957793653353125,early,sup,NA,NA
Cluster-53121.0,TCP13_ARATH,266.650542185755,-1.9690937898263,0.611983081992894,-3.21756245844908,0.00129284874770434,0.0541149547253387,early,sup,https://www.uniprot.org/uniprot/Q8LEB5,function:Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes; probably through the induction of miRNA (e.g. miR164). Binds to the 3'-ACC-5' repeats in the light-responsive promoter (LRP) of psbD; and activates its transcription. Participates in ovule develpment (PubMed:25378179).|subunit:Interacts with AHL27 and AHL29 (PubMed:24218605). Interacts with SPL (PubMed:25527103; PubMed:25378179). Interacts with KIN10; KIN11 and FLZ3 (Ref.11).|subcellular location:Nucleus|subcellular location:Plastid|subcellular location:Chloroplast|alternative products:Q9S7W5-1|alternative products:1|alternative products:Q9S7W5-2|alternative products:2|tissue specificity:Expressed in cotyledons; particularly in the vascular region; in leaves; buds; flowers and immature siliques; and; to a lower extent; in roots.|developmental stage:Expressed during ovule development (PubMed:25378179).
Cluster-55152.0,HQGT_RAUSE,18.7639384287034,-2.27451640671282,0.556560994693279,-4.0867334010108,4.37489347727877E-05,0.00441367458429347,early,sup,https://www.uniprot.org/uniprot/Q9AR73,function:Broad spectrum multifunctional glucosyltransferase. In addition to hydroquinone it accept at least 45 natural and synthetic phenols as well as two cinnamyl alcohols as substrates. Hydroquinone was however the best substrate. In contrast to this broad acceptor substrate specificity; only pyrimidine nucleotide activated glucose is tolerated as a donor substrate.|catalytic activity:hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP|similarity:Belongs to the UDP-glycosyltransferase family.
Cluster-55905.0,CLCB_ARATH,267.599438355561,-1.57177978114054,0.376234808725076,-4.17765646529818,2.9452804987717E-05,0.00320628124494744,early,sup,https://www.uniprot.org/uniprot/P92942,function:Voltage-gated chloride channel.|subunit:Homodimer (By similarity). Interacts with PP2A5 (PubMed:27676158).|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Broadly expressed in the plant.|similarity:Belongs to the chloride channel (TC 2.A.49) family.
Cluster-57253.0,TNG2_BOVIN,3019.41173623979,-6.33524201895769,0.627406303691684,-10.0975109457474,5.66620781961079E-24,2.60097826279534E-20,early,sup,https://www.uniprot.org/uniprot/Q29RZ5,subcellular location:Cytoplasm|subcellular location:Mitochondrion|subcellular location:Golgi apparatus|similarity:Belongs to the Tango2 family.|caution:Has been reported to be located in the Golgi apparatus (By similarity). However; another study was unable to detect Golgi localization (By similarity). Has also been reported to be located in the mitochondrion (By similarity). However; no mitochondrial localization was detected in another study which reported that the protein is primarily cytoplasmic (By similarity).
Cluster-57369.0,TAR2_ARATH,177.383351002345,-1.04034107243909,0.255154121311175,-4.07730459963973,4.55607901052153E-05,0.00453009126742903,early,sup,https://www.uniprot.org/uniprot/Q9SB62,function:Involved in auxin production. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots; while TAA1; TAR1 and TAR2 are required for proper embryo patterning. Involved in the maintenance of the root stem cell niches.|catalytic activity:2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate|catalytic activity:L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine|cofactor:pyridoxal 5'-phosphate|activity regulation:Inhibited by L-kynurenine.|pathway:Plant hormone metabolism; auxin biosynthesis.|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Expressed in roots; cotyledons and in the apical parts of hypocotyls. In roots; restricted to the provasculature of meristematic regions. Detected on the inner side of the apical hooks.|developmental stage:In early-stage flowers; expressed in all floral organs. Becomes later restricted to the gynoecia; preferentially to the outer cell layers that give rise to the valves. No expression in flowers at anthesis.|induction:Up-regulated by ethylene.|disruption phenotype:No visible phenotype.|similarity:Belongs to the alliinase family.
Cluster-5243.0,YTX2_XENLA,6.64148943654407,-6.58897041740926,1.52860372882566,-4.31045031040921,1.62922436178991E-05,0.00196807444615868,early,sup,https://www.uniprot.org/uniprot/P14381,NA
Cluster-24286.0,GAT22_ARATH,6.78493004741134,-6.45872524770471,1.16244321800735,-5.55616407550315,2.75767668335321E-08,7.83009600133137E-06,early,sup,https://www.uniprot.org/uniprot/A3E4C1,function:Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (PubMed:22102866; PubMed:25077795). Involved in the modulation of chloroplast development; growth and division in a cytokinin-dependent manner (PubMed:22102866; PubMed:22811435). Repressor of the gibberellic acid (GA) signaling pathway that regulates flowering and modulates greening; in a SOC1-dependent manner (PubMed:20844019; PubMed:23739688; PubMed:25077795). Prevents the accumulation of SOC1 during flowering (PubMed:23739688). Promotes chlorophyll biosynthesis throughout the plant; by regulating chlorophyll biosynthetic genes (e.g. HEMA1 and GUN4) and chloroplast localized glutamate synthase (e.g. GLU1) (PubMed:18417639; PubMed:20844019; PubMed:21453984; PubMed:22102866; PubMed:23878229; PubMed:25077795). Involved in the regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639). Regulator of germination; senescence; elongation growth and flowering time (PubMed:20844019; PubMed:22102866; PubMed:23878229). Influences also leaf starch content (PubMed:22102866).|subunit:Forms heterodimers with GATA18.|subcellular location:Nucleus|tissue specificity:Expressed predominantly in leaves; and barely in stems; flowers and siliques.|developmental stage:First observed in the inflorescence meristem (IM) and young flower buds (PubMed:23335616). Detected throughout the floral bud. In young flowers; restricted to the inner whorls; specifically the petals; stamens; and carpels (PubMed:18417639; PubMed:23335616). In older flowers; accumulates more in the stamens than in the petals and carpels (PubMed:18417639). Observed in anther locules; vascular strands; and ovules (PubMed:23335616). During imbibition; expressed in the endosperm; especially at the time of testa rupture. Later restricted to the cotyledons (PubMed:20844019). In mature embryos; restricted to the cotyledons. In young seedlings; mostly expressed in shoot tissues; including the tip; circumference; and vasculature of the cotyledons; the emerging leaves; the meristematic region; and the basal part of the hypocotyl; and; at low levels; in the primary roots. In older seedlings; accumulates in the green shoot tissues (PubMed:22811435).|induction:By light (including both red and white lights) (PubMed:17208962; PubMed:17587690). Levels follow a circadian and diurnal rhythm; with a peak at 20 hours; thus preempting dawn (PubMed:17208962). Activated by gibberellic acid (GA) (PubMed:20844019). Induced by cytokinin and derivatives (e.g. benzyladenine; t-Zeatin and 6-benzylaminopurine) in light conditions (PubMed:16212609; PubMed:17587690; PubMed:21453984; PubMed:22811435). Triggered by nitrate (PubMed:16262716). Negatively regulated by AP3/PI (PubMed:18417639). Strong accumulation during cold imbibition of nondormant seeds; but not at warm temperatures. Regulated by PIF transcription factors (PubMed:20844019). Repressed by HAN (PubMed:23335616). Inhibited by SOC1 (PubMed:23739688). Down-regulated by auxin (2;4D) and auxin response factors (e.g. ARF2 and ARF7) (PubMed:23878229).|disruption phenotype:Pale green leaves and reduced chlorophyll levels associated with altered regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639; PubMed:21453984; PubMed:22102866; PubMed:22811435). Reduced chloroplast size (PubMed:22811435). Faster seed germination. Early flowering. Increased leaves size (PubMed:20844019; PubMed:22102866). Reduced gibberellic acid (GA) levels due to increased GA turnover and associated with reduced expression of GA-anabolizing enzymes (e.g. GA3OX1) but increased expression of GA-catabolizing enzymes (e.g. GA2OX2) (PubMed:20844019). Small seeds with deformed seed coats (PubMed:22102866). The double mutant gnc cga1; lacking both GATA22 and GATA21; exhibits reduced sensitivity to cytokinin (e.g. benzyladenine) toward chloroplasts growth (PubMed:22811435).|similarity:Belongs to the type IV zinc-finger family. Class B subfamily.
Cluster-25253.0,RAA5A_ARATH,79.9803464782529,-1.76416224525098,0.178887898116897,-9.86183114577244,6.09279409432049E-23,2.09759668682219E-19,early,sup,https://www.uniprot.org/uniprot/Q9FGK5,function:Intracellular vesicle trafficking and protein transport.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Cytoplasmic side|similarity:Belongs to the small GTPase superfamily. Rab family.
Cluster-28269.0,C83B1_ARATH,31.4703681567685,-1.65554378093866,0.47772252224177,-3.46549242260931,0.00052926144091323,0.0284875863440945,early,sup,https://www.uniprot.org/uniprot/O65782,function:Involved in the metabolism of aromatic oximes. Catalyzes the oxime metabolizing step in indole glucosinolate biosynthesis by converting indole-3-acetaldoxime into indole-3-S-alkyl-thiohydroximate. Probably required for glucosinolate activation in response to pathogens. Functions in auxin homeostasis because indole-3-acetaldoxime also serves as a precursor for auxin biosynthesis. Specifically metabolizes (E)-p-hydroxyphenylacetaldoxime into an S-alkyl-thiohydroximate (PubMed:26361733).|catalytic activity:(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]|catalytic activity:(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]|cofactor:heme|biophysicochemical properties:3.1 uM for indole-3-acetaldoxime|biophysicochemical properties:65 uM for p-hydroxyphenylacetaldoxime|biophysicochemical properties:188 uM for phenylacetaldoxime|biophysicochemical properties:kcat is 52 min(-1) with indole-3-acetaldoxime as substrate. kcat is 14 min(-1) with p-hydroxyphenylacetaldoxime as substrate. kcat is 47 min(-1) with phenylacetaldoxime as substrate.|subcellular location:Membrane|subcellular location:Single-pass membrane protein|induction:By auxin and continuous red light. Stimulated by DOF1.1 and; transiently; by the generalist herbivore S.littoralis (PubMed:16740150).|disruption phenotype:Runt phenotype (small plants with hooked leaves). Epinastic leaves and defect in root development. High levels of endogenous free auxin. Altered tryptophan genes regulation.|miscellaneous:The sur2 mutant phenotype can be complemented by exogenous auxin or low pH medium. Plants overexpresseing SUR2 show decreased apical dominance.|similarity:Belongs to the cytochrome P450 family.
Cluster-31843.0,LET12_SOLLC,80.0966524187342,-1.04493920746424,0.336814126290977,-3.10242096722958,0.00191944792582655,0.0721220119687786,early,sup,https://www.uniprot.org/uniprot/O22300,function:May have a role to play in formative events in ovule and embryo morphogenesis.|subcellular location:Nucleus|tissue specificity:Ubiquitously expressed in the mature plant.|similarity:Belongs to the TALE/KNOX homeobox family.
Cluster-33994.0,AB42G_ORYSJ,25.2637254264919,-1.68896118900408,0.488337330496435,-3.45859528553164,0.00054300016314934,0.0289831598710449,early,sup,https://www.uniprot.org/uniprot/Q8GU93,function:May be a general defense protein.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|alternative products:Q5Z9S8-1|alternative products:1|alternative products:Q5Z9S8-2|alternative products:2|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-37832.0,GRXC9_ARATH,232.625199166408,-2.02927848030636,0.314166964998636,-6.45923571345309,1.05233092432487E-10,4.67472553512185E-08,early,sup,https://www.uniprot.org/uniprot/C1JGQ9,function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).|subunit:Interacts with TGA2 and TGA6.|subcellular location:Cytoplasm|subcellular location:Nucleus|induction:Up-regulated by salicylic acid (SA).|similarity:Belongs to the glutaredoxin family. CC-type subfamily.
Cluster-43129.0,CEPR1_ARATH,135.540184571049,-2.08320561575405,0.593178426055225,-3.51193759626063,0.0004448524404773,0.0252413986179703,early,sup,https://www.uniprot.org/uniprot/Q8GY29,function:Receptor kinase involved in the perception of C-terminally encoded plant signaling peptide (CEP) and subsequent regulation of root and shoot development (PubMed:25324386). Required for xylem and phloem cell files morphology and organization; probably by preventing ectopic lignification in phloem cells (PubMed:21853254). Together with CEPR2; mediates systemic nitrogen (N)-demand signaling upon the perception of root-derived peptides (e.g. CEP1) via the up-regulation of genes involved in N uptake and assimilation pathways (PubMed:25324386). Regulates positively lateral root initiation and development; probably repressed by the signaling peptide CEP5 (PubMed:27296247).|catalytic activity:ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]|subunit:Interacts with the root-derived peptides CEP1; CEP3 and CEP5.|subcellular location:Cell membrane|subcellular location:Single-pass membrane protein|tissue specificity:Expressed in the vasculature; especially in phloem and procambium regions; of stems; leaves; cotyledons; sepals; pedals; pedicels; hypocotyls and roots (in primary and lateral roots; but not in root tips) (PubMed:21853254; PubMed:25324386). Expressed in the root from the basal meristem onward. Present in the phloem pole pericycle and in the adjacent phloem (PubMed:27296247).|developmental stage:Expressed in the vasculature; especially in phloem and procambium regions; from the mature embryo stage through the adult plant (PubMed:21853254). Excluded from early stages of lateral root development (PubMed:27296247).|disruption phenotype:Defects in vascular organization and phloem differentiation in inflorescence stems; characterized by aberrant accumulation of highly lignified cells; typical of xylem or fiber cells; within the phloem; and phloem cells sometimes adjacent to xylem cells. Malformed vascular cells files; probably due to defects in oriented cell divisions or cell morphology; and leading to both phloem specification defects and disrupted xylem vessel formation. Short inflorescence stems and increased anthocyanin accumulation in leaves (PubMed:21853254). Reduced total lateral root density; due to a reduction in stage I and II lateral root primordia and; to a lower extent; to fewer emerged lateral roots. Impaired sensitivity to CEP5 with respect to root growth regulation (PubMed:27296247). Growth retardation accompanied with nitrogen (N)-deficiency symptoms. Slight enhanced lateral root elongation in simple mutant. The double mutant cepr1 cepr2 is insensitive to CEP1 in a root growth regulation and exhibit pleiotropic phenotype characterized by pale-green leaves and enhanced lateral root elongation. At adult stage; smaller rosette leaves and shorter floral stems; accompanied by anthocyanin accumulation. Down-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1; NRT2.1 and NRT3.1) leading to impaired nitrate uptake activity. Altered systemic induction of genes involved in N uptake and assimilation pathways in N-depletion conditions (PubMed:25324386).|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-44277.0,HSFA9_ARATH,97.3683443457194,-1.29448731386797,0.307539257031508,-4.20917747660211,2.56302012756892E-05,0.00286954066477655,early,sup,https://www.uniprot.org/uniprot/Q9LVW2,function:Seed-specific transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Seems to be specialized for the developmental expression of heat shock protein (HSP) genes during seed maturation. Activated by ABI3.|subunit:Homotrimer.|subcellular location:Nucleus|developmental stage:Starts to be expressed in seeds from 18 days after pollination (DAP) to reach the highest expression in dry seeds. Expression is strongly reduced after only 2 hours of seed imbibition; declines drastically after 6 hours; but can be detected at a very low level even after 10 hours.|domain:The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.|PTM:Exhibits temperature-dependent phosphorylation.|similarity:Belongs to the HSF family. Class A subfamily.
Cluster-47227.0,NA,189.873127003611,-3.37977856752223,0.301460768433497,-11.2113379962667,3.58729148754871E-29,4.94005910750333E-25,early,sup,NA,NA
Cluster-47354.1,FTCD_MOUSE,425.915562767127,-1.32746304113397,0.335426603917791,-3.95753653893034,7.57267064761529E-05,0.00670631816645081,early,sup,https://www.uniprot.org/uniprot/Q91XD4,function:Folate-dependent enzyme; that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).|function:Binds and promotes bundling of vimentin filaments originating from the Golgi.|catalytic activity:5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5;6;7;8-tetrahydrofolate + N-formimidoyl-L-glutamate|catalytic activity:5-formyltetrahydrofolate + L-glutamate = (6S)-5;6;7;8-tetrahydrofolate + H(+) + N-formyl-L-glutamate|catalytic activity:5-formimidoyltetrahydrofolate + 2 H(+) = 5;10-methenyltetrahydrofolate + NH4(+)|pathway:Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.|pathway:One-carbon metabolism; tetrahydrofolate interconversion.|subunit:Homooctamer; including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers; and form a planar ring-shaped structure (By similarity).|subcellular location:More abundantly located around the mother centriole.|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Microtubule organizing center|subcellular location:Centrosome|subcellular location:Centriole|subcellular location:Golgi apparatus|similarity:In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|similarity:In the N-terminal section; belongs to the formiminotransferase family.
Cluster-51373.0,ABI5_ARATH,40.1504538130846,-1.35255041206913,0.454284607519865,-2.97731948140018,0.00290780826717407,0.0957793653353125,early,sup,https://www.uniprot.org/uniprot/Q9SJN0,function:Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth. Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters. Can also trans-activate its own promoter; suggesting that it is autoregulated. Plays a role in sugar-mediated senescence.|subunit:DNA-binding homodimer. DNA-binding heterodimer with AREB3/DPBF3 or EEL/DPBF4. Interacts with ABI3; KEG; the mediator subunit MED25; and the AFP proteins AFP1; AFP2; AFP3 and AFP4. Interacts with TAP46. Interacts with the 36 kDa catalytic subunit (subunit C) of PP2A (PubMed:11489176; PubMed:12569131; PubMed:16247556; PubMed:17194765; PubMed:18484180; PubMed:22822206; PubMed:24357600). Interacts with FYPP1 and FYPP3 (PubMed:22715043). Interacts with FREE1 (via C-terminus) (PubMed:30962512).|subcellular location:Nucleus|tissue specificity:Predominantly expressed in seeds.|developmental stage:Expressed in embryo during the latest stages of seed maturation.|induction:Up-regulated by drought; salt; abscisic acid (ABA) and glucose or 2-deoxy-glucose (2DG). Autoregulated. Positively regulated by the light-signaling component HY5.|PTM:Phosphorylated by SRK2D and SRK2I in vitro.|PTM:Ubiquitinated. AFP1; KEG and RPN10 mediate its proteasome-dependent degradation. Its stability or degradation plays a central role in abscisic acid response. Sumoylated at Lys-391 by SIZ1. Sumoylation protects ABI5 from proteasome degradation; attenuating ABA signaling and sensitivity to ABA.|disruption phenotype:Exhibits abscisic acid (ABA) insensitivity.|similarity:Belongs to the bZIP family. ABI5 subfamily.
Cluster-54202.1,NA,45.2253513976378,-1.7573349350634,0.355454882931203,-4.94390433061944,7.65732917423438E-07,0.00014154238934011,early,sup,NA,NA
Cluster-56748.0,LOR15_ARATH,41.6816250112987,-1.22611316631437,0.395446777762412,-3.10057695564542,0.0019314401763425,0.0724737402409062,early,sup,https://www.uniprot.org/uniprot/Q8LEK9,function:Might be related to the phospholipid scramblase and tubby-like superfamily of membrane tethered transcription factors.|alternative products:Q9LZX1-1|alternative products:1|alternative products:Q9LZX1-2|alternative products:2|similarity:Belongs to the LOR family.
Cluster-57407.0,U86A1_ARATH,18.6920802368338,-2.59702602403352,0.645648232974881,-4.0223544205604,5.7619267745592E-05,0.00550491431265073,early,sup,https://www.uniprot.org/uniprot/Q9SJL0,similarity:Belongs to the UDP-glycosyltransferase family.
Cluster-631.1,AHP1_ARATH,8.9150004245257,-1.52208509353162,0.501429947016871,-3.03548901015362,0.00240145975089521,0.0841488606350584,early,sup,https://www.uniprot.org/uniprot/Q9ZNV9,function:Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.|subunit:Interacts with the B-type response regulators ARR1; ARR2; ARR4 and ARR9. Binds to ETR1; AHK2; AHK3; AHK4; AHK5 and FBR12.|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Nucleus|tissue specificity:Strongly expressed in roots.|induction:By salt; cold and drought stress.|domain:Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.|PTM:Two-component system major event consists of a His-to-Asp phosphorelay between a sensor histidine kinase (HK) and a response regulator (RR). In plants; the His-to-Asp phosphorelay involves an additional intermediate named Histidine-containing phosphotransfer protein (HPt). This multistep phosphorelay consists of a His-Asp-His-Asp sequential transfer of a phosphate group between first an His and an Asp of the HK protein; followed by the transfer to a conserved His of the HPt protein and finally the transfer to an Asp in the receiver domain of the RR protein.
Cluster-3513.1,DHAS_BACSU,12.9043356803489,-4.26067752341495,0.853834264056164,-4.9900521714536,6.03629872169201E-07,0.00011625995761737,early,sup,https://www.uniprot.org/uniprot/Q04797,function:Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|catalytic activity:L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH|pathway:Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.|pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.|pathway:Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.|subunit:Homodimer.|similarity:Belongs to the aspartate-semialdehyde dehydrogenase family.
Cluster-15902.0,NA,8.0546445782099,-1.67236007529116,0.480999412291327,-3.47684432154411,0.00050735231288111,0.027723110919728,early,sup,NA,NA
Cluster-17828.0,ERF61_ARATH,11.5417677215093,-3.84869931663187,0.72851014613298,-5.28297284129978,1.27104240149008E-07,2.77833728744761E-05,early,sup,https://www.uniprot.org/uniprot/Q9C7W2,function:Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).|subcellular location:Nucleus|similarity:Belongs to the AP2/ERF transcription factor family. ERF subfamily.
Cluster-18587.0,NPY3_ARATH,23.4448563830046,-1.46545467044354,0.419555538105868,-3.49287409495178,0.00047785175374344,0.0265342600838749,early,sup,https://www.uniprot.org/uniprot/Q93Y14,function:May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses.|pathway:Protein modification; protein ubiquitination.|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9FN09-1|alternative products:1|tissue specificity:Expressed in the provascular and vascular systems. Highly expressed in primary root tips.|similarity:Belongs to the NPH3 family.
Cluster-20188.1,PP2B8_ARATH,19.2601143381799,-1.59719035143328,0.496755400370925,-3.21524506878167,0.00130333201967415,0.0543884401300991,early,sup,https://www.uniprot.org/uniprot/Q9ZVQ8,NA
Cluster-21500.6,NA,541.304037504135,-1.46448999700416,0.420131038305809,-3.48579339177072,0.00049067982078108,0.0270827727934922,early,sup,NA,NA
Cluster-22449.2,NA,14.8033043884073,-1.48490376484758,0.462357349889345,-3.21159329510597,0.00132001102357492,0.0544449272114737,early,sup,NA,NA
Cluster-23418.0,AB19B_ARATH,15.36176588494,-1.52963763513806,0.468229692073154,-3.26685313006395,0.00108750083321047,0.0479231167172524,early,sup,https://www.uniprot.org/uniprot/Q8H6F5,function:Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin; as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues; and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism; phototropism and lateral root formation.|subunit:Interacts with 1-naphthylphthalamic acid (NPA); and FKBP42/TWD1.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Ubiquitous; mostly in shoot meristems.|developmental stage:In seedlings; confined to hypocotyls in darkness; but expressed in all tissues except in hypocotyls in light. In flowers; present in all organs except petals.|induction:By auxin (IAA). Induced by red light; but repressed by far-red light.|similarity:Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Cluster-26714.0,LRL12_ARATH,8.12134704220757,-1.93295272417856,0.566099419814829,-3.41451104968598,0.00063896601731643,0.0332673006596014,early,sup,https://www.uniprot.org/uniprot/Q9LPQ6,function:Probable receptor-like serine/threonine-protein kinase involved in abscisic acid (ABA) signaling. Acts as a positive regulator of abiotic stress response.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Isoform 1|subcellular location:Cell membrane|subcellular location:Single-pass type I membrane protein|subcellular location:Isoform 2|subcellular location:Membrane|subcellular location:Single-pass type I membrane protein|alternative products:A number of isoforms are produced by alternative splicing of isoform 1.|alternative products:P0C5E2-1|alternative products:1|alternative products:AtLRK10L-1.2|alternative products:P0C5E2-2|alternative products:2|alternative products:AtLRK10L-1.1|alternative products:P0C5E2-3|alternative products:3|disruption phenotype:ABA-insensitive and drought stress-semsitive. Late flowering.|miscellaneous:Isoform 2|miscellaneous:Produced by alternative promoter usage.|miscellaneous:Isoform 3|miscellaneous:Produced by alternative splicing of isoform 2. May be due to an intron retention.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|sequence caution:The predicted gene has been split into 2 genes: At1g18390 and At1g18400.|sequence caution:Cloning artifact.
Cluster-27925.0,NA,38.3396869688914,-1.25272515337745,0.329801938927882,-3.79841658132698,0.00014562342297673,0.0108988052055031,early,sup,NA,NA
Cluster-28273.0,PBL3_ARATH,7.01627066971294,-2.48580328238928,0.702477674133503,-3.53862247003862,0.00040222065246642,0.0238749164013582,early,sup,https://www.uniprot.org/uniprot/Q8GYU1,function:May be involved in plant defense signaling.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subunit:Interacts with the Xanthomonas campestris effector XopAC/AvrAC.|subcellular location:Predominantly localized at the plasma membrane.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Nucleus|tissue specificity:Strongly expressed in leaves; moderately in flowers; and barely in roots.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-28659.0,NA,27.0588548594276,-1.22038529409717,0.361757438999455,-3.37349052855,0.00074221599898223,0.0371674782617615,early,sup,NA,NA
Cluster-29817.0,NA,6.08635750486931,-5.49627501899474,1.40669183457787,-3.90723460810028,9.33584953197646E-05,0.00786048335629517,early,sup,NA,NA
Cluster-31349.0,MSL7_ARATH,42.1917397567782,-1.34555355043195,0.33848930169461,-3.9751730518382,7.03280991648101E-05,0.00641382949403047,early,sup,https://www.uniprot.org/uniprot/F4IME1,function:Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|developmental stage:Expressed during somatic embryogenesis.|similarity:Belongs to the MscS (TC 1.A.23) family.
Cluster-33496.1,PLY_ZINVI,160.974662229195,-1.59911076802438,0.532303606316997,-3.00413288402949,0.00266338969749227,0.0910805098399574,early,sup,https://www.uniprot.org/uniprot/O24554,function:Involved in the degradation of pectin. May assist in the removal and modification of an existing pectin matrix in order to allow the deposition of newly synthesized walls polymers for a specialized function or to create an architecture that is extensible.|catalytic activity:Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.|cofactor:Binds 1 Ca(2+) ion. Required for its activity.|cofactor:Ca(2+)|biophysicochemical properties:0.12 umol/min/mg enzyme|biophysicochemical properties:Optimum pH is 10.|pathway:Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.|tissue specificity:Expressed in sites of vascular differentiation and in new primordia on the flank of the shoot meristem.|induction:Up-regulated by auxin.|similarity:Belongs to the polysaccharide lyase 1 family.
Cluster-33496.2,PLY5_ARATH,1279.90040590764,-2.17607285038761,0.519904607802675,-4.18552330125437,2.84509879355102E-05,0.00312190083553714,early,sup,https://www.uniprot.org/uniprot/Q8W116,catalytic activity:Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.|cofactor:Binds 1 Ca(2+) ion. Required for its activity.|cofactor:Ca(2+)|pathway:Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.|similarity:Belongs to the polysaccharide lyase 1 family.
Cluster-36371.0,NA,947.170431211879,-1.98252011850221,0.534439605815583,-3.70953068771312,0.00020764378933968,0.0145890950152901,early,sup,NA,NA
Cluster-36835.0,KNAT6_ARATH,33.9200223403259,-1.33667231528961,0.327504214958004,-4.08138965619424,4.47672300996641E-05,0.00448310954835713,early,sup,https://www.uniprot.org/uniprot/Q9LR21,function:Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1; CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated; meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.|subunit:May form heterodimeric complex with the TALE/BELL protein BLH9/PNY. Interacts with OFP2 and OFP4.|subcellular location:Nucleus|alternative products:Q84JS6-1|alternative products:KNAT6S|alternative products:short|alternative products:Q84JS6-2|alternative products:KNAT6L|alternative products:long|tissue specificity:Expressed predominantly in shoot apices of seedlings; and; to a lower extent; in rosette leaves.|developmental stage:First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem; and between the cotyledons. In seedlings; localized in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots.|induction:Seems to be repressed by AS2 and AS1 but induced by STM; CUC1 and CUC2.|similarity:Belongs to the TALE/KNOX homeobox family.|caution:It is uncertain whether Met-1 or Met-4 is the initiator.|sequence caution:Truncated N-terminus.|sequence caution:Truncated N-terminus.
Cluster-39607.0,ZPR3_ARATH,9.33078716655032,-1.34560455790752,0.441570496786855,-3.04731536119145,0.00230895328376113,0.0819499888419445,early,sup,https://www.uniprot.org/uniprot/Q9LXI8,function:Competitive inhibitor of the HD-ZIPIII transcription factors in shoot apical meristem (SAM) development. Acts by forming non-functional heterodimers. Part of a negative feedback loop. Involved in SAM development and lateral organ patterning. Essential for proper functioning of stem cells in the SAM.|subunit:Interacts with REV (PubMed:18055602; PubMed:18408069). Interacts with ATBH-8; ATBH-9; ATB-14 and ATB-15 (PubMed:18408069).|subcellular location:Nucleus|tissue specificity:Expressed in the adaxial epidermis of the cotyledons and leaves; and in the vascular cylinder of wild-type torpedo stage embryos. Confined in the central zone and the organizing center in the shoot apical meristem.|induction:Up-regulated in response to increased HD-ZIPIII activity (PubMed:18055602). Up-regulated by ATHB-14 (PubMed:18408069). Up-regulated by REV (PubMed:22781836).|disruption phenotype:No visible phenotype during the vegetative growth. Disrupted activities of the shoot apical meristem and/or axillary meristems after the transition to reproductive growth. Zpr3 and zpr4 double mutants exhibit homeotic transformation and ectopic meristem activity.
Cluster-40899.1,CNGC2_ARATH,232.413400325689,-2.67165561785279,0.429764467492881,-6.2165577192513,5.08179506035799E-10,2.01715310623766E-07,early,sup,https://www.uniprot.org/uniprot/O65718,function:Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium; cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis; re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.|subunit:Homotetramer or heterotetramer (Potential). Binds calmodulin-1/4 with a higher affinity than calmodulin-2/3/5.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:O65718-1|alternative products:1|tissue specificity:Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques.|induction:Up-regulated by light. Transiently induced during leaf and culture senescence.|domain:The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.|miscellaneous:Loss-of-function mutations cngc2-1 (dnd1-1) or cncg2-2 results in the loss of the hypersensitive response and leads to a broad spectrum disease resistance. These mutations lead to a specific and dramatic calcium hypersensitivity that results in severe reductions in plant size and seed yield.|similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
Cluster-40899.2,CNGC2_ARATH,429.404533370441,-1.37194383654986,0.251507477967023,-5.4548828831632,4.90051335619357E-08,1.23825631978241E-05,early,sup,https://www.uniprot.org/uniprot/O65718,function:Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium; cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis; re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.|subunit:Homotetramer or heterotetramer (Potential). Binds calmodulin-1/4 with a higher affinity than calmodulin-2/3/5.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:O65718-1|alternative products:1|tissue specificity:Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques.|induction:Up-regulated by light. Transiently induced during leaf and culture senescence.|domain:The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.|miscellaneous:Loss-of-function mutations cngc2-1 (dnd1-1) or cncg2-2 results in the loss of the hypersensitive response and leads to a broad spectrum disease resistance. These mutations lead to a specific and dramatic calcium hypersensitivity that results in severe reductions in plant size and seed yield.|similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
Cluster-41094.2,ADS3_ARATH,33.3364965222263,-8.1319014182225,2.11836918826286,-3.83875552159581,0.00012365948172556,0.00964824205576603,early,sup,https://www.uniprot.org/uniprot/Q9LVZ4,function:Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7;10;13-trienoic acid (16:3(7Z;10Z;13Z)); the major functional components of thylakoid membranes (PubMed:15579662; PubMed:16666902; PubMed:15240892). Required for chloroplast biogenesis at low temperature (PubMed:16668849). Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).|catalytic activity:a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]|cofactor:Fe(2+)|pathway:Lipid metabolism; oxylipin biosynthesis.|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Plastid|subcellular location:Chloroplast membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in young leaves. Low expression in roots.|domain:The histidine box domains are involved in binding the catalytic metal ions.|miscellaneous:Substrate specificity shifts from delta-7 to delta-9 desaturation when the protein is retargeted to the cytoplasm.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-43903.0,FLZ3_ARATH,94.4270157505534,-1.13048305349893,0.319229896761179,-3.54128189423519,0.00039818791172119,0.0238164541197363,early,sup,https://www.uniprot.org/uniprot/O80506,subunit:Interacts with KIN10 and KIN11 via its FLZ-type zinc finger domain (PubMed:24600465; PubMed:29945970). Interacts with KINB3 via its N-terminal part (PubMed:29945970).|subcellular location:Shuttles from the cytoplasm to the nucleus when associated with KIN10.|subcellular location:Nucleus|subcellular location:Cytoplasm|induction:Down-regulated in response to mild as well as prolonged energy depletion.|similarity:Belongs to the FLZ family.
Cluster-45896.0,PRE1_ARATH,1093.65740573737,-2.04146438489923,0.299479114330096,-6.81671705042195,9.31444590709734E-12,4.93343209948606E-09,early,sup,https://www.uniprot.org/uniprot/Q9FLE9,function:Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Binds IBH1; forming a pair of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1; a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth and development.|subunit:Interacts with IBH1 and HFR1.|subcellular location:Nucleus|tissue specificity:Expressed in roots; leaves; stems and flowers.|induction:By gibberellin and epibrassinolide.|miscellaneous:Gain-of-function mutants (T-DNA tagging) show long hypocotyls; pale green and slightly narrow leaves; elongated petioles and early flowering. They are not sensitive to the gibberellin inhibitor paclobutrazol during seed germination (PubMed:16527868; PubMed:20009022; PubMed:23221598).
Cluster-46257.0,NA,38.9774535098032,-1.81411104995399,0.377898571327486,-4.80052370555772,1.58251240606098E-06,0.00027412299803604,early,sup,NA,NA
Cluster-46792.0,SAU23_ARATH,48.0990209526858,-1.8012300557647,0.452281420772463,-3.98254266710388,6.8181879373687E-05,0.0062387552216282,early,sup,https://www.uniprot.org/uniprot/Q9FJF6,function:Functions as positive effectors of cell expansion through modulation of auxin transport.|subcellular location:Cell membrane|subcellular location:Peripheral membrane protein|induction:By auxin.|similarity:Belongs to the ARG7 family.
Cluster-49142.0,RAD_ANTMA,4230.27811442411,-8.26044764578319,0.734827474654355,-11.2413429419861,2.55466171967704E-29,4.94005910750333E-25,early,sup,https://www.uniprot.org/uniprot/Q58FS3,function:Involved in the dorsovental asymmetry of flowers. Promotes dorsal identity.|subcellular location:Nucleus|tissue specificity:Specifically expressed in the dorsal region of developing flowers.|developmental stage:Early expressed at stage two (plastochrons 7 and 8); when the floral meristem comprised a loaf-shaped bulge of cells. Expression was in the dorsal region of the floral meristem. At stage four; when sepal primordia had emerged around the meristem dome; expression could be seen in the dorsal sepal primordium. At stage five; expressed in emerging dorsal primordia of whorls two and three. In older flower buds (stages seven and eight); expression was found mainly in the dorsal petals and staminode.|induction:Up-regulated by both CYC and DICH.|disruption phenotype:Radially symmetric flowers. Loss of functional stamens in dorsal positions. Organs reduction with five organs per whorl rather than six.
Cluster-49450.1,NA,242.472039670162,-1.40612873531783,0.379929740987235,-3.70102306722303,0.00021473195252087,0.0148224246524559,early,sup,NA,NA
Cluster-50283.0,NA,61.8125509903529,-2.33387520847583,0.331190324075897,-7.04693053756303,1.82907566430937E-12,1.20648065667606E-09,early,sup,NA,NA
Cluster-51214.0,FBK22_ARATH,26.2776821340122,-1.89084694816923,0.526823078750081,-3.58914980083138,0.00033175817164961,0.0207665535535762,early,sup,https://www.uniprot.org/uniprot/Q9C897,NA
Cluster-51481.0,NA,11.2739845130471,-1.90923982394356,0.54109623057085,-3.52846631721927,0.00041797513625915,0.0243895576331558,early,sup,NA,NA
Cluster-52138.0,NA,244.130522501933,-1.21127211804463,0.289249578085389,-4.18763659419082,2.81874377477253E-05,0.00310535364179141,early,sup,NA,NA
Cluster-52306.0,MTP3_ORYSJ,245.708741987004,-2.10206734525636,0.556672859433858,-3.77612687529653,0.00015928587739192,0.0117300845859047,early,sup,https://www.uniprot.org/uniprot/Q0DX45,function:Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.|subcellular location:Tonoplast.|subcellular location:Vacuole membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Cluster-52488.0,Y1133_ARATH,33.7346376862723,-1.80823464663438,0.465132641014665,-3.8875677327005,0.00010125373828235,0.00827516456905848,early,sup,https://www.uniprot.org/uniprot/Q0TV72,catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Cell membrane|subcellular location:Single-pass type I membrane protein|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9SXB8-1|alternative products:1|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-56526.0,NA,43.4671048105028,-1.8176530738922,0.542091543525394,-3.35303713109307,0.00079929982756698,0.0388259538815693,early,sup,NA,NA
Cluster-57115.2,SWET5_ORYSJ,6.63788573175866,-2.36268919396713,0.573698168068448,-4.11834885567428,3.81596723294443E-05,0.00393630597489721,early,sup,https://www.uniprot.org/uniprot/A0A0P0WQZ4,function:Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Can transport galactose. Prevents growth but promotes senescence (PubMed:25988582; PubMed:24709840). Involved in regulating the crosstalk between sugar and auxin. Regulates negatively the auxin signaling pathway and translocation (PubMed:24709840).|subunit:Forms homooligomers and/or heterooligomers.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Mainly expressed in the floral organs at the heading stage; and also in stem; root; senescing leaves; stamen; pistil and hull.|similarity:Belongs to the SWEET sugar transporter family.
Cluster-57166.0,NRAM1_ARATH,68.8304039803374,-3.75686142806945,1.01716680910628,-3.69345656428797,0.00022122631194188,0.0151567539390634,early,sup,https://www.uniprot.org/uniprot/Q9SP94,function:High affinity manganese (Mn) transporter involved in Mn acquisition from the soil. Required for Mn uptake into the root in conditions of low Mn availability. Can transport iron (Fe); cadmium (Cd) and cobalt (Co).|biophysicochemical properties:28 nM for Mn (2+)|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|induction:By Mn and Fe deficiency in roots.|disruption phenotype:No visible phenotype under normal growth condition; but under Mn limitation; very slow growth and unable to take up Mn.|similarity:Belongs to the NRAMP (TC 2.A.55) family.
Cluster-57253.1,TNG2_BOVIN,415.435615403742,-4.79678922525815,1.08277004984781,-4.43010889147919,9.41855178904681E-06,0.00129702876686964,early,sup,https://www.uniprot.org/uniprot/Q29RZ5,subcellular location:Cytoplasm|subcellular location:Mitochondrion|subcellular location:Golgi apparatus|similarity:Belongs to the Tango2 family.|caution:Has been reported to be located in the Golgi apparatus (By similarity). However; another study was unable to detect Golgi localization (By similarity). Has also been reported to be located in the mitochondrion (By similarity). However; no mitochondrial localization was detected in another study which reported that the protein is primarily cytoplasmic (By similarity).
Cluster-741.13,RGP1_PEA,839.042668690525,-1.28126673978053,0.323073708591092,-3.96586508189746,7.31302223550807E-05,0.00488410015865287,intermediate,sup,https://www.uniprot.org/uniprot/O04300,function:Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides (By similarity). Was initially shown to possess an autoglycosylating activity which is dependent on the presence of UDP-glucose and manganese (PubMed:9207152).|catalytic activity:UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose|cofactor:Mn(2+)|cofactor:Mg(2+)|activity regulation:Inhibited by inhibitor protein (IP) which may be a form of sucrose synthase.|subunit:Homopentamer or homohexamer.|subcellular location:Cell wall-associated; with highest concentrations on plasmodesmata. Also located in the Golgi apparatus.|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Cell junction|subcellular location:Plasmodesma|subcellular location:Golgi apparatus|domain:The conserved DXD motif is involved in enzyme activity.|PTM:Reversibly glycosylated by UDP-glucose; UDP-xylose and UDP-galactose; but not UDP-mannose.|similarity:Belongs to the RGP family.
Cluster-2195.0,IF2AH_ARATH,10.6541778457761,-3.60639430808484,0.950532183411462,-3.79407911801733,0.00014819241922532,0.00851011807449079,intermediate,sup,https://www.uniprot.org/uniprot/Q8LEV8,function:Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit; followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation; the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.|subunit:Heterotrimer composed of an alpha; a beta and a gamma chain.|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9SIZ2-1|alternative products:1|PTM:Phosphorylated at Ser-56 by GCN2.|similarity:Belongs to the eIF-2-alpha family.
Cluster-2578.0,RGLG2_ARATH,21.485078392434,-2.02361417179441,0.542094273102426,-3.73295618899124,0.00018924552147176,0.0102020668388277,intermediate,sup,https://www.uniprot.org/uniprot/Q9LY87,function:E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653). Mediates ubiquitination and subsequent proteasomal degradation of ERF053 in response to drought stress. Acts as a negative regulator of drought stress response (PubMed:22095047).|catalytic activity:S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.|subunit:Interacts with the heterodimer UBC35/UEV1B; UBC35 alone; PIN1; but not with UCB2; UCB9; UEV1B or UEV1C alone (PubMed:17586653). Interacts with ERF053 (PubMed:22095047).|subcellular location:Translocates to the nucleus under salt stress.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Nucleus|tissue specificity:Ubiquitously expressed.|domain:A C-terminal fragment containing the RING domain interacts with UBC35 while the full-length protein does not.|PTM:N-myristoylated.|disruption phenotype:No visible phenotype; due to the redundancy with RGLG1 (PubMed:17586653; PubMed:22095047). Rglg1 and rglg2 double mutants show a complete loss of apical dominance (PubMed:17586653). The double mutant seedlings rglg1 and rglg2 exhibit a dehydration-tolerant phenotype (PubMed:22095047).
Cluster-2601.0,NA,5.55487437525788,-1.90810184652856,0.609225621315419,-3.13201181921511,0.00173612886020348,0.0533345118239411,intermediate,sup,NA,NA
Cluster-19627.0,KCS15_ARATH,158.173441917454,-1.63791088010378,0.456120308985295,-3.59096240144963,0.00032945916584897,0.0156575726766565,intermediate,sup,https://www.uniprot.org/uniprot/Q8LFQ2,catalytic activity:a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA|pathway:Lipid metabolism; fatty acid biosynthesis.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in flowers.|induction:Repressed by herbicides such as flufenacet and benfuresate.|similarity:Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.|sequence caution:Truncated N-terminus.
Cluster-26767.0,VESTR_MEDSA,13.1747185210476,-2.80855660024641,0.703904155440623,-3.98997019486032,6.6081598568878E-05,0.0045745665529839,intermediate,sup,https://www.uniprot.org/uniprot/Q40316,function:Stereospecific enzyme that catalyzes the NADPH-dependent reduction of (3R)-vestitone to (3R;4R)-4'-methoxyisoflavan-2';4;7-triol (DMI). Has no activity with (3S)-vestitone. Catalyzes the penultimate step in the biosynthesis of the phytoalexin medicarpin; and thereby contributes to plant defense reactions.|catalytic activity:a (3R;4R)-4;2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH|activity regulation:Inhibited by vestitone concentrations above 50 uM.|biophysicochemical properties:40 uM for vestitone|biophysicochemical properties:Optimum pH is 6.0.|biophysicochemical properties:Optimum temperature is 30 degrees Celsius.|subunit:Monomer.|tissue specificity:Detected in roots; and at lower levels in root nodules. Not detected in petioles; leaf and stem.|induction:Transiently up-regulated by fungal elicitors; peaking 6 hours after elicitor treatment.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Cluster-27569.0,AMO_ARATH,91.8694206941025,-1.44421240305204,0.298243286730884,-4.84239702050764,1.28282122976161E-06,0.00018434323463318,intermediate,sup,https://www.uniprot.org/uniprot/Q9SI68,catalytic activity:an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)|cofactor:Binds 1 copper ion per subunit (By similarity). Can also use zinc ion as cofactor (By similarity).|cofactor:Cu cation|cofactor:Zn(2+)|cofactor:Contains 1 topaquinone per subunit.|cofactor:L-topaquinone|cofactor:Binds 1 Mn(2+) ion per subunit.|cofactor:Mn(2+)|subunit:Homodimer.|PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.|similarity:Belongs to the copper/topaquinone oxidase family.|sequence caution:The predicted gene has been split into 3 genes: At1g62810; At1g62820 and At1g62830.
Cluster-27665.0,CDPKW_ARATH,19.6241814761201,-1.55323965406637,0.488297075365119,-3.18093171642478,0.00146802226938494,0.0471524398623101,intermediate,sup,https://www.uniprot.org/uniprot/Q9SCM0,function:May play a role in signal transduction pathways that involve calcium as a second messenger. Involved in maintaining Ca2+ homeostasis in pollen tube tips by regulating CNGC18 (PubMed:24121288). Functions as regulator of the calcium-mediated abscisic acid (ABA) signaling pathway (PubMed:16299177). Phosphorylates ABA-responsive transcription factor ABF4 in vitro (PubMed:16299177).|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|activity regulation:Activated by calcium. Autophosphorylation may play an important role in the regulation of the kinase activity (By similarity).|subunit:Interacts with ABF4 (PubMed:16299177). Interacts with CNGC18 (PubMed:24121288).|subcellular location:Nucleus|subcellular location:Membrane|subcellular location:Lipid-anchor|alternative products:Q6NLQ6-1|alternative products:1|alternative products:Q6NLQ6-2|alternative products:2|tissue specificity:Expressed in embryos and most of the vegetative tissues.|induction:Induced by touch; wounding; and darkness exposure. Also induced by high-salt treatment.|domain:There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain; an autoinhibitory (junction) domain and a calmodulin-like domain. The autoinhibitory domain (327-357) inactivates kinase activity under calcium-free conditions (By similarity).|miscellaneous:Isoform 2|miscellaneous:May be due to intron retention.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
Cluster-28612.1,GPAT6_ARATH,2049.84959352972,-1.938431076745,0.461586447248807,-4.19949738190674,2.67508123180538E-05,0.00228482078956538,intermediate,sup,https://www.uniprot.org/uniprot/O80437,function:Esterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate; a step in cutin biosynthesis.|catalytic activity:an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA|biophysicochemical properties:278.56 pmol/min/mg enzyme|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Specifically expressed in flower buds.|domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.|similarity:Belongs to the GPAT/DAPAT family.
Cluster-29266.0,LEA65_ARATH,237.47532818882,-1.22414529415561,0.208813925340178,-5.86237384389646,4.56296264702344E-09,1.29302420953643E-06,intermediate,sup,https://www.uniprot.org/uniprot/Q56ZH1,similarity:Belongs to the LEA type 3 family.
Cluster-29874.0,Y3795_ARATH,63.7034388002479,-1.03325794192695,0.255798162930433,-4.03934856329657,5.35998612106012E-05,0.0039161479319678,intermediate,sup,https://www.uniprot.org/uniprot/Q6E250,subunit:Interacts with RLK902.|alternative products:Q6DR24-1|alternative products:1|alternative products:Q6DR24-2|alternative products:2|tissue specificity:Expressed in inflorescences; stems; rosette leaves and weakly in roots.|induction:Rapid but transient down-regulation by wounding; salicylic acid treatment or pathogen infection.
Cluster-30995.0,PDR1_NICPL,8.91508132086199,-3.61088479045517,1.22502183350411,-2.94760851741428,0.00320242331260065,0.0831799745598505,intermediate,sup,https://www.uniprot.org/uniprot/Q949G3,function:Excretes secondary metabolites such as terpenes. Involved in both constitutive and jasmonic acid-dependent induced defense. Confers some resistance to sclareol and B.cinerea.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Roots; petals and leaf epidermis; where it is confined to glandular trichomes (at protein level).|induction:By terpenes such as sclareolide and sclareol; and by some phytohormones such as jasmonic acid (JA) and ethylene. Strongly induced by compatible pathogens such as the fungus B.cinerea; and the bacteria P.syringae pv tabaci; as well as by non pathogenic bacteria such as P.fluorescens; and P.marginalis pv marginalis. Weak induction by incompatible pathogens such as P.syringae pv syringae (at protein level).|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-31030.1,TKPR1_ARATH,297.157923409707,-1.17920190455743,0.357504578596251,-3.29842462210578,0.00097228980887341,0.0348061384827045,intermediate,sup,https://www.uniprot.org/uniprot/O65487,function:Involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine). Is essential for pollen wall development. Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.|subunit:Interacts with 4CLL1/ACOS5; PKSA and PKSB.|subcellular location:According to PubMed:21193572; TKPR1 is associated with the endoplasmic reticulum.|subcellular location:Cytoplasm|subcellular location:Nucleus|subcellular location:Endoplasmic reticulum|tissue specificity:Specifically expressed in anther tapetal cells during microspores development.|disruption phenotype:Male sterility due to distorted pollen grains lacking reticulate exine pattern.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Cluster-31912.1,CK1_ARATH,96.2289897731357,-1.03854519034431,0.309589003704326,-3.3545932766274,0.00079481751683434,0.0299003249726231,intermediate,sup,https://www.uniprot.org/uniprot/Q9C9J3,function:Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).|catalytic activity:ATP + choline = ADP + H(+) + phosphocholine|pathway:Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.|tissue specificity:Expressed in roots. Expressed at low levels in cauline leaves and flowers.|induction:By wounding; and salt and osmotic stresses.|similarity:Belongs to the choline/ethanolamine kinase family.
Cluster-32499.0,FAH2_ARATH,34.4641149467975,-1.30315283885662,0.438456734829708,-2.97213552749451,0.00295736107469476,0.0788655630130342,intermediate,sup,https://www.uniprot.org/uniprot/Q9SUC5,function:Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of the long-chain fatty acid (LCFA) palmitic acid. Probably involved in the resistance response to oxidative stress.|catalytic activity:an N-(1;2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O|cofactor:Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|cofactor:Zn(2+)|subunit:Interacts with CYTB5-A; CYTB5-B; CYTB5-C and CYTB5-D.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in leaves; roots; flowers and seeds.|induction:Not induced by H(2)O(2) treatment.|disruption phenotype:No visible phenotype under normal growth conditions.|similarity:Belongs to the sterol desaturase family.
Cluster-32593.0,Y5576_ARATH,19.3595189980357,-1.91297883955463,0.509738202158721,-3.75286535608522,0.00017482476588855,0.00967310534034108,intermediate,sup,https://www.uniprot.org/uniprot/Q9FHH7,catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|alternative products:Q5XF57-1|alternative products:1|alternative products:Q5XF57-2|alternative products:2|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-32903.2,TRXH2_ARATH,180.092316567784,-1.24724546670082,0.23589821728228,-5.2872187041937,1.2419012610482E-07,2.54430325244882E-05,intermediate,sup,https://www.uniprot.org/uniprot/Q39240,function:Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.|subunit:Interacts with MDH1.|subcellular location:Cytoplasm|subcellular location:Mitochondrion|similarity:Belongs to the thioredoxin family. Plant H-type subfamily.
Cluster-33261.0,SCP40_ARATH,12.2466386986986,-2.80049165597269,0.805356579932765,-3.47733131603207,0.00050643160115085,0.0216885770882696,intermediate,sup,https://www.uniprot.org/uniprot/Q9LY68,function:Probable carboxypeptidase.|subcellular location:Secreted|tissue specificity:Expressed in roots; leaves; flowers and siliques.|similarity:Belongs to the peptidase S10 family.
Cluster-33757.0,BBX32_ARATH,7.97650790748422,-1.72178347791055,0.59205464268868,-2.90814960945407,0.00363574354610944,0.0892626559203111,intermediate,sup,https://www.uniprot.org/uniprot/Q9LJB7,function:Repressor of light-mediated regulation of seedling development. Functions by suppressing the activities of positive cofactors like BBX21 and HY5 involved in modulating light-regulated gene expression and growth.|subunit:Interacts with BBX21.|subcellular location:Nucleus
Cluster-34063.0,ATAD1_RAT,43.5165729148201,-1.39686260690314,0.351148321961351,-3.97798457102377,6.95018804427857E-05,0.00476588056128793,intermediate,sup,https://www.uniprot.org/uniprot/B3STU2,function:Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR); thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).|catalytic activity:[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate|biophysicochemical properties:43.4 mM for ATP|biophysicochemical properties:11.0 nM/min/mg enzyme|subcellular location:Mitochondrion outer membrane|subcellular location:Single-pass membrane protein|subcellular location:Peroxisome membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell junction|subcellular location:Synapse|subcellular location:Postsynaptic cell membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the AAA ATPase family. MSP1 subfamily.|sequence caution:Truncated N-terminus.
Cluster-34818.0,C71A1_PERAE,121.305910434871,-2.44143213725247,0.375208328992895,-6.50687084640571,7.67323277084918E-11,2.80313362463757E-08,intermediate,sup,https://www.uniprot.org/uniprot/P24465,function:Involved in the metabolism of compounds associated with the development of flavor in the ripening fruit process; possibly by acting as trans-cinnamic acid 4-hydrolase.|cofactor:heme|subcellular location:Microsome membrane|subcellular location:Single-pass membrane protein|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|tissue specificity:Mesocarp.|developmental stage:In ripening fruit.|induction:By ethylene.|similarity:Belongs to the cytochrome P450 family.
Cluster-34838.0,M3K17_ARATH,117.147346443156,-1.32626957854046,0.312669790942735,-4.24175797265737,2.21775779947985E-05,0.00197778335994202,intermediate,sup,https://www.uniprot.org/uniprot/O80888,function:Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Triggers MPK7 activation in a MKK3-dependent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subunit:Binds to MKK3.|subcellular location:Nucleus|induction:Strongly induced by abscisic acid (ABA). Accumulates in response to osmotic stresses (e.g. mannitol and NaCl).|disruption phenotype:In the double mutant map3k17 map3k18; impaired MPK7 activation mediated by abscisic acid (ABA).|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-34959.0,UBC5A_ORYSJ,100.457181150869,-1.00658504662281,0.272471934140854,-3.69427056697316,0.00022051889946134,0.0114128544423562,intermediate,sup,https://www.uniprot.org/uniprot/A0A0P0V661,function:E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.|catalytic activity:S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.|pathway:Protein modification; protein ubiquitination.|similarity:Belongs to the ubiquitin-conjugating enzyme family.
Cluster-35245.0,RHD3_ARATH,38.0118560182677,-1.3039699943029,0.38362004330417,-3.39911852121082,0.00067603413974453,0.0265862920248949,intermediate,sup,https://www.uniprot.org/uniprot/Q3EB66,function:Probable GTP-binding protein involved in cell wall expansion. Required for appropriate root and root hair cells enlargement. May inhibit vacuole enlargement during root hair cell expansion. Plays a role in cell wall biosynthesis and actin organization. Seems to act independently from auxin and ethylene pathways. May regulate membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).|subcellular location:Endoplasmic reticulum membrane|subcellular location:Multi-pass membrane protein|subcellular location:Golgi apparatus membrane|alternative products:P93042-1|alternative products:1|alternative products:P93042-2|alternative products:2|tissue specificity:Highly expressed in fiber and xylem cells. Expressed in roots; cotyledons; seedling hypocotyls; stems; pedicel; stigmatic papillae cells and anthers.|developmental stage:Expressed in the embryo throughout development.|disruption phenotype:Reduced root and root hair length due to defect in epidermal cell growth and enlargement. Reduced size of vacuole and increase in the proportion of cytoplasm in root hair cells. Strong reduction in the cell wall thickness of fibers; vessels and pith cells in the inflorescence stems. Reduced cellulose content and altered composition of the cell wall. Altered organization of the actin cytoskeleton.|similarity:Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
Cluster-35370.0,PME31_ARATH,48.2508880213777,-1.84369358079808,0.630083503251478,-2.92610990651858,0.00343229656280078,0.0859377903226113,intermediate,sup,https://www.uniprot.org/uniprot/Q9LVQ0,function:Acts in the modification of cell walls via demethylesterification of cell wall pectin (PubMed:18936961). Acts in a blockwise manner; resulting in a cell wall rigidification.|catalytic activity:[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol|activity regulation:Does not require salt for activity. Not inhibited by kiwi pectin methylesterase inhibitor (PMEI).|biophysicochemical properties:Optimum pH is 8.0-8.5.|biophysicochemical properties:Fully active at 0 or 30 degrees Celsius; inactive at 55 degrees Celsius.|pathway:Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.|tissue specificity:Expressed in siliques.|developmental stage:Expressed during late developmental phases of siliques.|miscellaneous:This is the only member of the pectinesterase family that do not contain a transmembrane or a signal peptide.|similarity:Belongs to the pectinesterase family.
Cluster-36060.0,NLTP3_ARATH,21.1055067124692,-4.16460067808089,1.0720968409766,-3.88453777579202,0.0001025247519097,0.00638327105267772,intermediate,sup,https://www.uniprot.org/uniprot/Q9FIE6,function:Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).|similarity:Belongs to the plant LTP family.
Cluster-36358.0,NA,32.8116151177855,-1.03788095528264,0.309864445695324,-3.34946770983574,0.00080966992517334,0.0301749802451551,intermediate,sup,NA,NA
Cluster-36494.0,NA,17.621170846677,-1.16002954959958,0.3375642976113,-3.43646990457307,0.00058934782550944,0.0242135710261134,intermediate,sup,NA,NA
Cluster-36699.0,PLCD4_ARATH,25.8631343052268,-1.56674944791536,0.436593802839259,-3.58857463785896,0.00033249080949374,0.0157451164998073,intermediate,sup,https://www.uniprot.org/uniprot/Q9LUY9,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1;4;5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.|catalytic activity:a 1;2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4;5-bisphosphate) + H2O = 1D-myo-inositol 1;4;5-trisphosphate + a 1;2-diacyl-sn-glycerol + H(+)|cofactor:Ca(2+)|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Cell membrane|subcellular location:Peripheral membrane protein|alternative products:Q944C1-1|alternative products:1|alternative products:Q944C1-2|alternative products:2|tissue specificity:Low expression in leaves; roots; flowers and siliques. Expressed in pollen and in cells of the stigma surface.|induction:By environmental stresses such as dehydration; salinity and low temperature.
Cluster-37151.2,NRAM3_ORYSJ,716.201497538524,-1.83560422459051,0.625490291237503,-2.93466461479178,0.00333908384965342,0.0851512220985162,intermediate,sup,https://www.uniprot.org/uniprot/Q653V6,function:Probable metal transporter.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the NRAMP (TC 2.A.55) family.
Cluster-38402.0,14312_ARATH,24.8158962382658,-1.59217102273985,0.456999418810077,-3.48396728137094,0.00049403987877839,0.0214056742253298,intermediate,sup,https://www.uniprot.org/uniprot/Q9FZD3,function:Is associated with a DNA binding complex that binds to the G box; a well-characterized cis-acting DNA regulatory element found in plant genes.|subcellular location:Translocates from the cytosol to the nucleus when phosphorylated.|subcellular location:Nucleus|subcellular location:Cytoplasm|tissue specificity:Expressed in flowers.|similarity:Belongs to the 14-3-3 family.|sequence caution:Truncated N-terminus.
Cluster-38643.0,EC14_ARATH,7.07588745644369,-6.96605942198046,1.63330077123664,-4.26501936731847,1.99884862389628E-05,0.00179842994436674,intermediate,sup,https://www.uniprot.org/uniprot/A0MFC9,subcellular location:Secreted via vesicle exocytose upon sperm arrival; especially in the apical region of the degenerating synergid cell.|subcellular location:Cytoplasmic vesicle|subcellular location:Secreted|tissue specificity:Restricted to female reproductive tissues; specifically accumulating in storage vesicles of the unfertilized egg cell.|developmental stage:Confined to the egg cell before fertilization; but disappears upon gamete fusion. Also present in zygotes and early embryos.|similarity:Belongs to the plant egg cell-secreted peptide family.|sequence caution:Extended C-terminus.
Cluster-38699.0,DRP1A_ARATH,20.5202502166492,-1.78394235556431,0.610041959216684,-2.92429451550342,0.00345237932522394,0.0862270127842792,intermediate,sup,https://www.uniprot.org/uniprot/Q8LPS7,function:Microtubule-associated force-producing protein that is targeted to at the leading edges of the forming cell plate during cytokinesis (PubMed:18612642). Plays also a major role in plasma membrane maintenance and cell wall integrity with implications in vesicular trafficking; polar cell expansion; vascular formation; and other aspects of plant growth and development; including stigmatic papillae expansion (PubMed:18256049; PubMed:18344418). Collaboratively with DRP2B; participates in clathrin-coated vesicle formation during endocytosis (PubMed:20231465). Necessary for BOR1 polar localization in low-boron (B) conditions as well as for BOR1 endocytosis and subsequent degradation under high-concentration of boron (PubMed:27449211). Has a GTPase activity (PubMed:20171176). Required for the sterols-dependent dynamic high lipid order observed at the cell plate of dividing cells (PubMed:25234576). Together with SH3P2; converts the fused vesicles to tubular structures at the cell plate and phragmoplasts during cytokinesis (PubMed:28584166; PubMed:18256049). With DRP2B and PIP5K3; required for the precise coordination of polar ARAC3/ROP6 and ARAC4/ROP2 placement and subsequent root hair positioning during planar polarity formation in root hair-forming cells; probably by mediating the correct basal-to-planar polarity switching of D6PK into the polar; lipid-enriched domain (PubMed:27251533). Involved in endocytosis required for cellulose deposition during cell wall formation and elongation (PubMed:18256049). Interacts with plasma membrane-mimetic liposomes and induces their clustering (PubMed:20171176).|catalytic activity:GTP + H2O = GDP + H(+) + phosphate|biophysicochemical properties:99 uM for GTP|biophysicochemical properties:kcat is 28 min(-1) with GTP as substrate.|subunit:Forms homodimer and may homooligomerize and heterooligomerize to form the phragmoplastin complex (PubMed:20171176; PubMed:20231465). Interacts with AGD3/VAN3. May interact with CALS1. Binds to AHK2. Binds to SH3P2 (PubMed:28584166). Forms a complex made of SH3P2 and DRP1A and triggers its accumulation at the cell plate (PubMed:28584166). Interacts with DRP2B at the plasma membrane and in forming clathrin-coated vesicles (CCV) (PubMed:20231465). Binds to PHIP1 (PubMed:18621982).|subcellular location:Microtubule-associated and localized in the forming cell plate; at the vicinity of sterols; during cytokinesis; especially at the leading edges (PubMed:14750520; PubMed:28584166; PubMed:18612642; PubMed:25234576). Accumulates in a sterol-enriched; polar membrane domain during root hair initiation (PubMed:27251533). Forms discreet dynamic foci in the epidermal cell cortex; which colocalize with part of the clathrin endocytic machinery (PubMed:18344418). Co-localizes with BOR1 in the cell plate and the plasma membrane (PubMed:27449211).|subcellular location:Cytoplasm|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Phragmoplast|subcellular location:Cytoplasm|subcellular location:Cell cortex|subcellular location:Cytoplasmic vesicle|subcellular location:Clathrin-coated vesicle|subcellular location:Cell membrane|alternative products:P42697-1|alternative products:1|alternative products:P42697-2|alternative products:2|tissue specificity:Ubiquitous. Expressed in leaves (at protein level).|disruption phenotype:Vascular discontinuity (PubMed:15923323; PubMed:18344418). Short and swollen roots and hypocotyls due to cellulose-deficient walls associated with increased levels of arabinose; xylose; and galactose in non-cellulosic polysaccharides (PubMed:18256049). Infertility due to the inability of stigmatic papillae to undergo rapid polar expansion prior to fertilization (PubMed:18344418). The alteration of cell wall formation correlates with abnormal phragmoplasts and division plates in dividing cells; as well as reduced cell elongation and disturbed endocytosis (PubMed:18256049). Hypersensitivity to trafficking inhibitors (e.g. brefeldin A; monensin A and latrunculin B) (PubMed:18256049). Both basal and apical shift of ARAC3/ROP6 and ARAC4/ROP2 positioning and broad lateral localization of D6PK in root hair-forming cells leading to basal and apical shift of root hair positions (PubMed:27251533).|similarity:Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Cluster-39322.0,HAT22_ARATH,198.877289985339,-1.15527382536606,0.261545279917961,-4.41710829470305,1.00030120172549E-05,0.0010476981502717,intermediate,sup,https://www.uniprot.org/uniprot/Q546G6,function:Probable transcription factor.|subcellular location:Nucleus|similarity:Belongs to the HD-ZIP homeobox family. Class II subfamily.
Cluster-39620.0,USPAL_ARATH,70.0587816023838,-3.06712142249271,0.673670287443625,-4.55285245565975,5.29233914125565E-06,0.00059653908959855,intermediate,sup,https://www.uniprot.org/uniprot/Q9SSA2,subunit:Homohexamer.|similarity:Belongs to the universal stress protein A family.
Cluster-40103.0,NA,56.9485912857473,-1.05451240048106,0.340102834308251,-3.10056928112897,0.00193149022984004,0.0579275126201582,intermediate,sup,NA,NA
Cluster-40329.0,DOF37_ARATH,27.5896982845071,-4.1990124409064,0.57519673113312,-7.30013265658599,2.87484143360406E-13,1.81600139808976E-10,intermediate,sup,https://www.uniprot.org/uniprot/Q9SAF9,function:Transcription factor specifically involved in the maternal control of seed germination. Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence. May ensure the inactivity of a component that would be activated to trigger germination as a consequence of red light perception.|subcellular location:Nucleus|alternative products:Q43385-1|alternative products:1|alternative products:Q43385-2|alternative products:2|tissue specificity:Expressed in the phloem of the mother plant; including in roots; stem; leaves and flowers; but not present in the seed and embryo. In maturing siliques; found all through the funiculus connecting the placenta to the ovule; but not in the ovule.|developmental stage:Turned off in siliques when they reached full maturation. Not expressed in developing or mature embryos.|miscellaneous:The regulatory role of DOF3.7/DAG1 appears to be opposite to that of DOF2.5/DAG2. Both zinc finger proteins may act on a maternal switch that controls seed germination; possibly by regulating the same gene(s).
Cluster-41606.0,NAC7_ARATH,19.6404765021214,-1.10432456639026,0.367765457649374,-3.00279578579432,0.00267511873127758,0.0740075502290763,intermediate,sup,NA,NA
Cluster-42148.0,REN1_ARATH,128.007730599366,-1.24103885198032,0.431466776801247,-2.8763254060509,0.00402334704289841,0.096200776309193,intermediate,sup,https://www.uniprot.org/uniprot/Q9SB53,function:Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Maintains the global inactivation of ARAC11/ROP1 at the apex in pollen tubes in order to regulate the polar cell growth.|subunit:Interacts with ARAC11/ROP1.|subcellular location:Localizes to the apical plasma membrane and accumulates in the clear zone of growing pollen tubes.|subcellular location:Cell membrane|subcellular location:Peripheral membrane protein|tissue specificity:Expressed in pollen and pollen tubes.|disruption phenotype:Male gametophyte defect characterized by sterile pollen grains developing balloon-like tubes.
Cluster-42491.0,APA1_ARATH,336.277617874698,-1.44630117493537,0.385495581622955,-3.75179702150249,0.00017557158733073,0.0096791019990097,intermediate,sup,https://www.uniprot.org/uniprot/Q38934,function:Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles (By similarity). Possesses aspartic protease activity in vitro.|biophysicochemical properties:Optimum pH is 5.0-6.0 with insulin B chain as substrate and at 37 degrees Celsius.|subcellular location:Located in protein storage vacuoles (PSV) of the embryo.|subcellular location:Vacuole|tissue specificity:Expressed in roots; leaves; stems; petals; carpels; seed pods and dry seeds.|induction:By light and during senescence.|similarity:Belongs to the peptidase A1 family.
Cluster-44233.2,TSJT1_TOBAC,561.023259324449,-1.26175726272606,0.40666406271328,-3.10270166069645,0.00191762848624603,0.0576257812997679,intermediate,sup,https://www.uniprot.org/uniprot/P24805,tissue specificity:Stem-specific (active at lower levels in other organs).
Cluster-44233.3,TSJT1_TOBAC,508.354751584389,-1.37078350996949,0.421486476057942,-3.25225977068135,0.00114491331838827,0.0391689305164228,intermediate,sup,https://www.uniprot.org/uniprot/P24805,tissue specificity:Stem-specific (active at lower levels in other organs).
Cluster-44397.0,BH091_ARATH,10.5600158540077,-2.28289220779743,0.565820852089582,-4.03465549098568,5.46824689736945E-05,0.00397105255856515,intermediate,sup,https://www.uniprot.org/uniprot/Q9SJX5,subunit:Homodimer.|subcellular location:Nucleus|tissue specificity:Flowers.
Cluster-44468.0,WTR14_ARATH,19.5827638366529,-2.50660444520491,0.811610549674759,-3.08843255698117,0.00201215359435229,0.0598729235862178,intermediate,sup,https://www.uniprot.org/uniprot/O80638,subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
Cluster-44519.0,PER1_SORBI,5.59241924317891,-5.19518417128918,1.37910554187583,-3.76706786648308,0.00016517611003389,0.00932858812205561,intermediate,sup,https://www.uniprot.org/uniprot/C5XIP7,function:Removal of H(2)O(2); oxidation of toxic reductants; biosynthesis and degradation of lignin; suberization; auxin catabolism; response to environmental stresses such as wounding; pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue (By similarity). Has a high preference for hydroxycinnamates as substrates. Substrate preference is ferulic acid > p-coumaric acid > N-acetyl tyrosine methyl ester > N-acetyl-tyrosine > tyrosine > catechol > Gly-Tyr-Gly. May be involved in the formation of diferulate linkages in the plant cell wall (PubMed:16650004).|catalytic activity:2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O|cofactor:Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|cofactor:heme b|cofactor:Binds 2 calcium ions per subunit.|cofactor:Ca(2+)|biophysicochemical properties:Optimum pH is 3.8 with 2.2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) as substrate; 5.5 with ferulic acid as substrate; and 6.5 with N-acetyl-L-tyrosine as substrate.|biophysicochemical properties:Loss of activity at temperature above 55 degrees Celsius. In the presence of excess calcium; full activity is kept at 65 degrees Celsius for 90 minutes.|subunit:Monomer.|subcellular location:Secreted|tissue specificity:Present in germinated and ungerminated grain; seedlings; and leaves and stem of the mature plant.|PTM:The proportions of glycoforms I and II are 35% and 65% respectively.|mass spectrometry:Deglycosylated form.|mass spectrometry:Glycoform I.|mass spectrometry:Glycoform II.|similarity:Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Cluster-45226.0,NA,47.4742876004418,-1.20370263613461,0.382688805259587,-3.14538240886902,0.00165869860766539,0.0516498031887053,intermediate,sup,NA,NA
Cluster-45715.0,KASC1_ARATH,15.2335615986874,-4.48024292148529,1.00394024971258,-4.46265893091543,8.09488465422279E-06,0.00087658927714531,intermediate,sup,https://www.uniprot.org/uniprot/Q9FL32,function:Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).|catalytic activity:a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]|subunit:Homodimer.|subcellular location:Plastid|subcellular location:Chloroplast stroma|alternative products:P52410-1|alternative products:1|alternative products:P52410-2|alternative products:2|similarity:Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Cluster-46295.0,NPC3_ARATH,86.0820634683706,-1.0410980917982,0.284247028822247,-3.66265250374612,0.0002496170542322,0.0125934088209229,intermediate,sup,https://www.uniprot.org/uniprot/Q8VZ53,function:Possesses specific phosphatase activity toward lysophosphatidic acid (LPA) in vitro. Does not show phospholipase C activity. May play a role in signal transduction and storage lipid synthesis. May be involved in brassinolide-mediated signaling in root development.|catalytic activity:a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate|tissue specificity:Expressed in root tips; cotyledons; on leaf margins; stems; young anthers and funiculus.|induction:Induced by auxin in roots. Not induced by inorganic phosphate deprivation.|disruption phenotype:No visible phenotype under normal growth conditions.|similarity:Belongs to the bacterial phospholipase C family.
Cluster-46461.0,IQD31_ARATH,18.6249388596037,-2.24201894619693,0.49103762388504,-4.56588016302765,4.97402874740718E-06,0.00056485964662971,intermediate,sup,https://www.uniprot.org/uniprot/Q9SSF5,subunit:Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.|subcellular location:Associates to cortical microtubules (MTs).|subcellular location:Nucleus|subcellular location:Nucleus envelope|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Cell membrane|similarity:Belongs to the IQD family.
Cluster-47122.0,KOR1_ORYSJ,34.429086708215,-1.52953316192073,0.360193745036412,-4.24641788759022,2.17215333948678E-05,0.00194282777010556,intermediate,sup,https://www.uniprot.org/uniprot/Q0DD66,function:Probable outward-rectifying potassium channel.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids. The pore-forming region H5 is enclosed by the transmembrane segments S5 and S6 in the Shaker-type (1P/6TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity (By similarity).|domain:The KHA domain (rich in hydrophobic and acidic residues) present in the C-terminal part is likely to be important for tetramerization.|similarity:Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.
Cluster-47768.0,CCH_ARATH,321.68451143323,-1.17394781510648,0.391269449108331,-3.00035644945396,0.00269663829211379,0.074399244454215,intermediate,sup,https://www.uniprot.org/uniprot/O82089,function:Involved in copper homeostasis. Can complement the yeast mutants atx1 and sod1.|cofactor:Binds 1 copper ion per subunit.|cofactor:Cu cation|tissue specificity:Expressed in phloem (at protein level).|induction:Induced by copper deficiency; ozone and senescence. Down-regulated by excess of copper.|disruption phenotype:No visible phenotype under normal growth conditions.|similarity:Belongs to the ATX1 family.
Cluster-47833.0,DHEB_NICPL,454.583420674489,-1.3056993444151,0.323777090839796,-4.03271071782271,5.51371368739793E-05,0.00397105255856515,intermediate,sup,https://www.uniprot.org/uniprot/O24119,catalytic activity:H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)|catalytic activity:H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)|similarity:Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Cluster-50416.0,FAO4A_ARATH,306.620510794797,-3.69145926002231,0.343862876778908,-10.7352654482554,6.95188897217432E-27,3.51313709208829E-23,intermediate,sup,https://www.uniprot.org/uniprot/O65709,function:Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.|catalytic activity:a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2|subcellular location:Membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the GMC oxidoreductase family.
Cluster-50757.0,DOF17_ARATH,51.4668137057743,-1.40927097317591,0.293881061789704,-4.79537866303329,1.62367826902679E-06,0.00022493979866917,intermediate,sup,https://www.uniprot.org/uniprot/O82155,function:Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.|subcellular location:Nucleus
Cluster-52579.0,TGA1_ARATH,53.2358688774954,-2.223988470774,0.643488877936107,-3.4561412745891,0.00054796804105494,0.0229202668809735,intermediate,sup,https://www.uniprot.org/uniprot/Q9FJP4,subunit:Binds DNA as a dimer. The reduced form interacts with NPR1.|subcellular location:Nucleus|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q39237-1|alternative products:1|tissue specificity:Predominantly expressed in roots.|similarity:Belongs to the bZIP family.
Cluster-53102.1,CVIF1_ARATH,33.3197825679043,-3.82799845087151,0.773755519203104,-4.94729711888065,7.52510690494546E-07,0.00011641263595145,intermediate,sup,https://www.uniprot.org/uniprot/Q9C7Y8,function:Inhibits fructosidases from vacuoles (vacuolar invertase VI).|subcellular location:Vacuole|alternative products:F4HWQ8-1|alternative products:1|alternative products:F4HWQ8-2|alternative products:2|tissue specificity:Mostly expressed in roots; senescent leaves and flowers (in sepals); and; to a lower extent; in stems; specifically in the vascular tissues (e.g. in the phloem).|disruption phenotype:Increased vacuolar invertase activity leading to accumulation of hexose.|similarity:Belongs to the PMEI family.
Cluster-53121.0,TCP13_ARATH,266.650542185755,-2.51345581845417,0.623532544135182,-4.03099379831128,5.55415093675916E-05,0.00399069693254678,intermediate,sup,https://www.uniprot.org/uniprot/Q8LEB5,function:Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes; probably through the induction of miRNA (e.g. miR164). Binds to the 3'-ACC-5' repeats in the light-responsive promoter (LRP) of psbD; and activates its transcription. Participates in ovule develpment (PubMed:25378179).|subunit:Interacts with AHL27 and AHL29 (PubMed:24218605). Interacts with SPL (PubMed:25527103; PubMed:25378179). Interacts with KIN10; KIN11 and FLZ3 (Ref.11).|subcellular location:Nucleus|subcellular location:Plastid|subcellular location:Chloroplast|alternative products:Q9S7W5-1|alternative products:1|alternative products:Q9S7W5-2|alternative products:2|tissue specificity:Expressed in cotyledons; particularly in the vascular region; in leaves; buds; flowers and immature siliques; and; to a lower extent; in roots.|developmental stage:Expressed during ovule development (PubMed:25378179).
Cluster-53137.0,WAKLQ_ARATH,143.272987306933,-1.1633192943688,0.271859444399794,-4.27912039965046,1.87633349883434E-05,0.00171362373548663,intermediate,sup,https://www.uniprot.org/uniprot/Q9LZM4,function:Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Membrane|subcellular location:Single-pass type I membrane protein|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|caution:Lacks the calcium-binding EGF-like domain which is a conserved feature of the wall-associated receptor kinase family.
Cluster-53276.0,COL10_ARATH,55.0822322465064,-1.0301247723491,0.35238151293194,-2.92332240638305,0.00346317719690734,0.0864255109361543,intermediate,sup,https://www.uniprot.org/uniprot/Q9LUA9,subcellular location:Nucleus|similarity:Belongs to the CONSTANS family.
Cluster-53340.0,GDL66_ARATH,2022.35907767668,-2.11901472856565,0.456199950912651,-4.64492537609102,3.40199402250539E-06,0.00041096358867086,intermediate,sup,https://www.uniprot.org/uniprot/Q9SZ19,subcellular location:Secreted|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-53656.0,ZWIP2_ARATH,144.370460412061,-1.46479436235374,0.198406824232731,-7.38278215992985,1.55015548898692E-13,1.00004818258664E-10,intermediate,sup,https://www.uniprot.org/uniprot/Q84TI0,function:Transcriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth. In Arabidopsis; the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712). May play a role in the regulation of AGL8/FUL; which is required for normal pattern of cell division; expansion and differentiation during morphogenesis of the silique (PubMed:23515580). Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392).|subunit:Can form homodimers. Interacts with BLH9; STM; AGL8/FUL; AGL1/SHP1 and AGL5/SHP2.|subcellular location:Nucleus|tissue specificity:Expressed in developing carpels (PubMed:17600712). Expressed in the shoot apical meristem and the replum (PubMed:25039392).|disruption phenotype:Reduced fertility; fruit length and seed set (PubMed:17600712). Reduced replum width and cell number (PubMed:25039392).|miscellaneous:The fruits of the gain-of-function mutant ntt-3D (T-DNA tagging) fail to dehisce.|similarity:Belongs to the WIP C2H2-type zinc-finger protein family.
Cluster-54099.0,RNP1_ARATH,7.01424736431559,-1.76242954000517,0.526204010824966,-3.34932745427404,0.00081007994193978,0.0301749802451551,intermediate,sup,https://www.uniprot.org/uniprot/O23288,function:Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (By similarity).|function:Involved in the packaging of pre-mRNA into hnRNP particles; transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.|subunit:Component of the spliceosome (By similarity). Interacts with TRN1.|subcellular location:Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. Relocalization from the cytoplasm into the nucleus is mediated by TRN1 (By similarity).|subcellular location:Nucleus|subcellular location:Cytoplasm
Cluster-54138.0,AB29G_ARATH,31.1561198342486,-3.58488487799887,0.496429645555042,-7.22133520851827,5.1479579617724E-13,2.9451176105453E-10,intermediate,sup,https://www.uniprot.org/uniprot/O04323,function:May be a general defense protein.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|alternative products:Q94A18-1|alternative products:1|alternative products:Q94A18-2|alternative products:2|tissue specificity:Expressed in roots and stems; and; to a lower extent; in seedling and inflorescence.|induction:Repressed by cold/dark treatment.|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-54850.0,NUDT8_ARATH,86.2490250364035,-1.01957299015343,0.295029304235735,-3.45583633732455,0.00054858830228042,0.0229202668809735,intermediate,sup,https://www.uniprot.org/uniprot/Q9LVT5,function:Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity). May be involved in plant immunity and act as a positive regulator of defense response through salicylic acid (SA) signaling (PubMed:25436909).|cofactor:Mg(2+)|cofactor:Mn(2+)|tissue specificity:Expressed in roots; stems and; at lower level; leaves.|induction:Circadian regulation with a peak after 8 hours of light. Induced by abscisic acid (ABA). Down-regulated by salicylic acid (SA).|disruption phenotype:Small and stunted plant phenotype when grown on 12/12 hour photoperiod light. No visible phenotype when grown under short or long day light (8/16 hours or 16/8 hours of light/dark).|similarity:Belongs to the Nudix hydrolase family.
Cluster-55048.1,SUI11_ARATH,536.798658455072,-1.09596278301765,0.1672518332476,-6.55276992626551,5.64795004686898E-11,2.0884328459892E-08,intermediate,sup,https://www.uniprot.org/uniprot/Q9SLK5,function:Probably involved in translation.|similarity:Belongs to the SUI1 family.
Cluster-55069.0,GAOX2_ARATH,61.004454991475,-3.20017250458798,0.426583213385914,-7.50187162590691,6.2912972227726E-14,4.65264446565093E-11,intermediate,sup,https://www.uniprot.org/uniprot/Q39111,function:Key oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA12 to GA9; via a three-step oxidation at C-20 of the GA skeleton; and GA25 is also formed as a minor product. GA53 is less effectively oxidized than GA12 and is only oxidized one step to GA44 (PubMed:7630935). Involved in the promotion of the floral transition; fertility and silique elongation; but plays only a minor role in elongation of seedling organs. Acts redundantly with GA20OX1 (PubMed:18069939).|catalytic activity:2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate|catalytic activity:2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate|catalytic activity:2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate|catalytic activity:2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate|catalytic activity:3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate|cofactor:Binds 1 Fe(2+) ion per subunit.|cofactor:Fe(2+)|cofactor:L-ascorbate|pathway:Plant hormone biosynthesis; gibberellin biosynthesis.|tissue specificity:Expressed in inflorescence and developing siliques. Detected in seeds; roots; cotyledons and leaves. In seeds; specifically detected at the rim of the embryo and the outer integument.|developmental stage:Expressed in developing siliques 3-13 days after pollination.|induction:Negatively controlled by the level of physiologically active gibberellin. Up-regulated by auxin; paclobutrazol; long day exposure and cold treatment.|disruption phenotype:Slightly smaller than the wild type.|similarity:Belongs to the iron/ascorbate-dependent oxidoreductase family. GA20OX subfamily.
Cluster-55152.0,HQGT_RAUSE,18.7639384287034,-1.57876307666062,0.49836532260254,-3.16788308708174,0.00153553257359307,0.0489063898780624,intermediate,sup,https://www.uniprot.org/uniprot/Q9AR73,function:Broad spectrum multifunctional glucosyltransferase. In addition to hydroquinone it accept at least 45 natural and synthetic phenols as well as two cinnamyl alcohols as substrates. Hydroquinone was however the best substrate. In contrast to this broad acceptor substrate specificity; only pyrimidine nucleotide activated glucose is tolerated as a donor substrate.|catalytic activity:hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP|similarity:Belongs to the UDP-glycosyltransferase family.
Cluster-55291.1,CNGC4_ARATH,227.075692639642,-2.19584342308497,0.438533363779955,-5.00724370013221,5.52150009431576E-07,8.858063722738E-05,intermediate,sup,https://www.uniprot.org/uniprot/Q9XFS2,function:Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and sodium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Might constitute a common downstream component of the signaling pathways leading to hypersensitive response (HR).|subunit:Homotetramer or heterotetramer.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|alternative products:Q94AS9-1|alternative products:1|alternative products:Q94AS9-2|alternative products:2|induction:Induced by both ethylene and methyl jasmonate treatments; or after pathogen attack.|domain:The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.|disruption phenotype:Loss-of-function mutation results in the loss of the hypersensitive response leading to broad spectrum disease resistance; and displays a lesion-mimic phenotype.|similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
Cluster-55292.0,HMA5_ORYSJ,24.8291481456105,-1.53180932184583,0.395657579141384,-3.87155308681311,0.00010814409775383,0.00663772710120274,intermediate,sup,https://www.uniprot.org/uniprot/Q7XU05,function:Copper (Cu) transporter that plays an essential role in promoting translocation of Cu from roots to shoots. Involved in loading Cu to the xylem of the roots and other organs; including panicles.|catalytic activity:ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in root pericycle cells; xylem region of diffuse vascular bundles in the first node; and vascular tissues of peduncle; rachis and husk.|induction:Weakly induced by high copper concentration.|disruption phenotype:Reduced grain yield. Increased levels of copper in roots. Decreased levels of copper in shoots and grains.|similarity:Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
Cluster-55390.0,NA,67.5747595298231,-1.29481792339774,0.246617168038696,-5.25031543300575,1.51838974669102E-07,2.93242646556806E-05,intermediate,sup,NA,NA
Cluster-55543.0,ALDH_CRAPL,93.4937920760957,-1.19197676886059,0.283208667741562,-4.20882869993339,2.5669789919798E-05,0.00219868276880846,intermediate,sup,https://www.uniprot.org/uniprot/Q8VXQ2,function:Oxidizes nonanal; propionaldehyde and acetaldehyde in vitro; in the following decreasing order of reactivity: nonanal; propionaldehyde; acetaldehyde.|catalytic activity:an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH|biophysicochemical properties:2.2 uM for nonanal|biophysicochemical properties:267 uM for propionaldehyde|biophysicochemical properties:32.3 mM for acetaldehyde|biophysicochemical properties:0.03 umol/sec/mg enzyme with nonanal as substrate|biophysicochemical properties:0.196 umol/sec/mg enzyme with propionaldehyde as substrate|biophysicochemical properties:0.102 umol/sec/mg enzyme with acetaldehyde as substrate|biophysicochemical properties:Measured at pH 9.5 for all experiments.|subcellular location:Plastid|subcellular location:Amyloplast|subcellular location:Plastid|subcellular location:Chloroplast|induction:By abscisic acid (ABA) and dehydration.|similarity:Belongs to the aldehyde dehydrogenase family.
Cluster-55638.0,Y3081_ARATH,105.377697876766,-1.27006518899023,0.43840505058739,-2.89701313269215,0.00376733984600602,0.0917717504375803,intermediate,sup,https://www.uniprot.org/uniprot/Q9SVL7,sequence caution:The predicted gene has been split into 2 genes: At3g50808 and At3g50810.
Cluster-55905.0,CLCB_ARATH,267.599438355561,-1.18373718413517,0.367145280581727,-3.22416560076596,0.00126340316069677,0.042189038805602,intermediate,sup,https://www.uniprot.org/uniprot/P92942,function:Voltage-gated chloride channel.|subunit:Homodimer (By similarity). Interacts with PP2A5 (PubMed:27676158).|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Broadly expressed in the plant.|similarity:Belongs to the chloride channel (TC 2.A.49) family.
Cluster-55919.0,NAC42_ARATH,9.12040542992049,-6.96735492245976,1.36138148199773,-5.11785639410614,3.09027746885203E-07,5.3871937627805E-05,intermediate,sup,NA,NA
Cluster-56195.0,IX10L_ARATH,136.617704389256,-1.04089728265102,0.304027404683076,-3.42369558341647,0.00061775780015014,0.0251086250111964,intermediate,sup,https://www.uniprot.org/uniprot/W8PUW2,function:Involved in the synthesis of the hemicellulose glucuronoxylan; a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone.|subcellular location:Golgi apparatus membrane|subcellular location:Single-pass type II membrane protein|tissue specificity:Present in the xylem and phloem; and; to a lower extent; in interfascicular cells. Expressed in the root tip; shoot apical meristem (SAM); xylem cells of roots and stems; and in the vasculature of roots; cotyledons and leaves.|developmental stage:In flowers; expressed in anthers; stigmas and styles.|disruption phenotype:No visible phenotype (PubMed:18980662). Slightly short inflorescence and reduced fertility (PubMed:18980649).|similarity:Belongs to the glycosyltransferase 47 family.
Cluster-56228.0,4CLL7_ARATH,9.75123435191644,-4.25889934262732,1.12117506390944,-3.79860334012149,0.000145513756591,0.00838806580531544,intermediate,sup,https://www.uniprot.org/uniprot/Q9M0X9,function:Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.|catalytic activity:ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA|catalytic activity:(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA|catalytic activity:ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA|catalytic activity:(9Z;12Z)-octadecadienoate + ATP + CoA = (9Z;12Z)-octadecadienoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA|catalytic activity:ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA|catalytic activity:(9Z;12Z;15Z)-octadecatrienoate + ATP + CoA = (9Z;12Z;15Z)-octadecatrienoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA|biophysicochemical properties:75 uM for hexanoic acid|biophysicochemical properties:6 uM for nonanoic acid|biophysicochemical properties:54 uM for tetradecanoic acid|biophysicochemical properties:93 uM for OPDA|biophysicochemical properties:187 uM for OPC-6:0|biophysicochemical properties:kcat is 1.26 sec(-1) with hexanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 1.38 sec(-1) with nonanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 2.31 sec(-1) with tetradecanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 0.3 sec(-1) with OPDA as substrate (PubMed:18267944; PubMed:15677481). kcat is 0.41 sec(-1) with OPC-6:0 as substrate (PubMed:18267944; PubMed:15677481).|subcellular location:Peroxisome|tissue specificity:Expressed at low level in leaves.|induction:By methyl jasmonate.|domain:Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition; and are sufficient to confer the substrate specificity.|disruption phenotype:No obvious phenotype in growth; root and flower development; fertility; reproduction and morphology.|similarity:Belongs to the ATP-dependent AMP-binding enzyme family.
Cluster-56692.0,RAC2A_ARATH,50.5010046587007,-1.2654661298364,0.273769112936031,-4.62238459359033,3.79353864732207E-06,0.00044410766534923,intermediate,sup,https://www.uniprot.org/uniprot/O49841,function:Intracellular vesicle trafficking and protein transport.|subunit:Interacts with XI-2/MYA2.|subcellular location:Colocalizes with peroxisome.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Cytoplasmic side|subcellular location:Cytoplasm|similarity:Belongs to the small GTPase superfamily. Rab family.
Cluster-57356.0,NA,221.986259834567,-1.52918254041983,0.299854917372818,-5.09974141434056,3.40117816148963E-07,5.85949562696176E-05,intermediate,sup,NA,NA
Cluster-5243.0,YTX2_XENLA,6.64148943654407,-5.4593607267363,1.5131611901337,-3.60791749242123,0.00030866460810675,0.0149744313318477,intermediate,sup,https://www.uniprot.org/uniprot/P14381,NA
Cluster-13656.1,FBD15_ARATH,7.74363824436834,-1.42189802443503,0.481887583827987,-2.95068408515498,0.00317071038139151,0.0825937366616597,intermediate,sup,https://www.uniprot.org/uniprot/Q8LEE0,NA
Cluster-22742.0,NLTPC_RICCO,11.6563060227282,-5.52077355801507,1.61149316812969,-3.42587462807708,0.0006128231780701,0.0249414920567297,intermediate,sup,https://www.uniprot.org/uniprot/Q43120,function:Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.|similarity:Belongs to the plant LTP family.
Cluster-24286.0,GAT22_ARATH,6.78493004741134,-5.09203287338689,1.17405155349112,-4.33714589299372,1.44344818993281E-05,0.00139558727289467,intermediate,sup,https://www.uniprot.org/uniprot/A3E4C1,function:Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (PubMed:22102866; PubMed:25077795). Involved in the modulation of chloroplast development; growth and division in a cytokinin-dependent manner (PubMed:22102866; PubMed:22811435). Repressor of the gibberellic acid (GA) signaling pathway that regulates flowering and modulates greening; in a SOC1-dependent manner (PubMed:20844019; PubMed:23739688; PubMed:25077795). Prevents the accumulation of SOC1 during flowering (PubMed:23739688). Promotes chlorophyll biosynthesis throughout the plant; by regulating chlorophyll biosynthetic genes (e.g. HEMA1 and GUN4) and chloroplast localized glutamate synthase (e.g. GLU1) (PubMed:18417639; PubMed:20844019; PubMed:21453984; PubMed:22102866; PubMed:23878229; PubMed:25077795). Involved in the regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639). Regulator of germination; senescence; elongation growth and flowering time (PubMed:20844019; PubMed:22102866; PubMed:23878229). Influences also leaf starch content (PubMed:22102866).|subunit:Forms heterodimers with GATA18.|subcellular location:Nucleus|tissue specificity:Expressed predominantly in leaves; and barely in stems; flowers and siliques.|developmental stage:First observed in the inflorescence meristem (IM) and young flower buds (PubMed:23335616). Detected throughout the floral bud. In young flowers; restricted to the inner whorls; specifically the petals; stamens; and carpels (PubMed:18417639; PubMed:23335616). In older flowers; accumulates more in the stamens than in the petals and carpels (PubMed:18417639). Observed in anther locules; vascular strands; and ovules (PubMed:23335616). During imbibition; expressed in the endosperm; especially at the time of testa rupture. Later restricted to the cotyledons (PubMed:20844019). In mature embryos; restricted to the cotyledons. In young seedlings; mostly expressed in shoot tissues; including the tip; circumference; and vasculature of the cotyledons; the emerging leaves; the meristematic region; and the basal part of the hypocotyl; and; at low levels; in the primary roots. In older seedlings; accumulates in the green shoot tissues (PubMed:22811435).|induction:By light (including both red and white lights) (PubMed:17208962; PubMed:17587690). Levels follow a circadian and diurnal rhythm; with a peak at 20 hours; thus preempting dawn (PubMed:17208962). Activated by gibberellic acid (GA) (PubMed:20844019). Induced by cytokinin and derivatives (e.g. benzyladenine; t-Zeatin and 6-benzylaminopurine) in light conditions (PubMed:16212609; PubMed:17587690; PubMed:21453984; PubMed:22811435). Triggered by nitrate (PubMed:16262716). Negatively regulated by AP3/PI (PubMed:18417639). Strong accumulation during cold imbibition of nondormant seeds; but not at warm temperatures. Regulated by PIF transcription factors (PubMed:20844019). Repressed by HAN (PubMed:23335616). Inhibited by SOC1 (PubMed:23739688). Down-regulated by auxin (2;4D) and auxin response factors (e.g. ARF2 and ARF7) (PubMed:23878229).|disruption phenotype:Pale green leaves and reduced chlorophyll levels associated with altered regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639; PubMed:21453984; PubMed:22102866; PubMed:22811435). Reduced chloroplast size (PubMed:22811435). Faster seed germination. Early flowering. Increased leaves size (PubMed:20844019; PubMed:22102866). Reduced gibberellic acid (GA) levels due to increased GA turnover and associated with reduced expression of GA-anabolizing enzymes (e.g. GA3OX1) but increased expression of GA-catabolizing enzymes (e.g. GA2OX2) (PubMed:20844019). Small seeds with deformed seed coats (PubMed:22102866). The double mutant gnc cga1; lacking both GATA22 and GATA21; exhibits reduced sensitivity to cytokinin (e.g. benzyladenine) toward chloroplasts growth (PubMed:22811435).|similarity:Belongs to the type IV zinc-finger family. Class B subfamily.
Cluster-25253.0,RAA5A_ARATH,79.9803464782529,-1.15440568803215,0.186540933938327,-6.18848455220994,6.07453594049603E-10,1.89882478610082E-07,intermediate,sup,https://www.uniprot.org/uniprot/Q9FGK5,function:Intracellular vesicle trafficking and protein transport.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Cytoplasmic side|similarity:Belongs to the small GTPase superfamily. Rab family.
Cluster-27078.0,CLE27_ARATH,19.2631899273393,-1.16077917737534,0.388348547545284,-2.98901382459784,0.00279879467914154,0.0759733692625343,intermediate,sup,https://www.uniprot.org/uniprot/Q8LC08,function:CLE27p|function:Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance.|subcellular location:CLE27p|subcellular location:Secreted|subcellular location:Extracellular space|tissue specificity:CLE27p|tissue specificity:Mostly expressed in apex; and; to a lower extent; in roots; leaves; flowers and siliques.|PTM:CLE27p|PTM:The O-glycosylation (arabinosylation) of the hydroxyproline Pro-86 enhances binding affinity of the CLE27p peptide for its receptor.|similarity:Belongs to the CLV3/ESR signal peptide family.|sequence caution:Truncated N-terminus.
Cluster-28594.0,DTX30_ARATH,128.09060233884,-1.12590548912776,0.279095883514579,-4.03411714622779,5.48079716138906E-05,0.00397105255856515,intermediate,sup,https://www.uniprot.org/uniprot/Q9LS19,subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Cluster-30616.0,C71DA_SOYBN,4.85561091066131,-3.38882391771176,1.05178280334163,-3.22198072353446,0.00127307699870706,0.0423256827978788,intermediate,sup,https://www.uniprot.org/uniprot/O48923,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-31843.0,LET12_SOLLC,80.0966524187342,-1.58660969862088,0.341063692992393,-4.65194546127272,3.28818054428124E-06,0.0003988036891326,intermediate,sup,https://www.uniprot.org/uniprot/O22300,function:May have a role to play in formative events in ovule and embryo morphogenesis.|subcellular location:Nucleus|tissue specificity:Ubiquitously expressed in the mature plant.|similarity:Belongs to the TALE/KNOX homeobox family.
Cluster-33994.0,AB42G_ORYSJ,25.2637254264919,-3.28640386134924,0.534949028176577,-6.14339626440905,8.0775432425768E-10,2.44919188658171E-07,intermediate,sup,https://www.uniprot.org/uniprot/Q8GU93,function:May be a general defense protein.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|alternative products:Q5Z9S8-1|alternative products:1|alternative products:Q5Z9S8-2|alternative products:2|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-35752.0,AAE_RAUSE,5.42461269111232,-4.12927051088519,1.42084467256523,-2.90620825106104,0.00365837879464331,0.0896007297515184,intermediate,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-35752.2,AAE_RAUSE,6.60384718040827,-3.47214075940158,1.14423370563618,-3.03446817053087,0.00240960180267132,0.068409678144941,intermediate,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-36029.0,NA,64.629571775119,-3.11308352677644,1.07158539535548,-2.90511940557358,0.00367113019505142,0.0898404670251444,intermediate,sup,NA,NA
Cluster-37832.0,GRXC9_ARATH,232.625199166408,-1.63103670280169,0.314921228128659,-5.17918945157722,2.22852061008612E-07,4.14545849192769E-05,intermediate,sup,https://www.uniprot.org/uniprot/C1JGQ9,function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).|subunit:Interacts with TGA2 and TGA6.|subcellular location:Cytoplasm|subcellular location:Nucleus|induction:Up-regulated by salicylic acid (SA).|similarity:Belongs to the glutaredoxin family. CC-type subfamily.
Cluster-39352.0,C71DA_SOYBN,14.2030592720077,-2.91648116087014,0.914040850964221,-3.19075581555633,0.00141901155518842,0.04582092584118,intermediate,sup,https://www.uniprot.org/uniprot/O48923,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-39382.0,EXPB2_ARATH,21.5892227767786,-2.96052130695199,0.594672594454253,-4.97840548658365,6.41102360718561E-07,0.00010177416062485,intermediate,sup,https://www.uniprot.org/uniprot/O04484,function:May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Membrane|subcellular location:Peripheral membrane protein|similarity:Belongs to the expansin family. Expansin B subfamily.
Cluster-39837.0,VINSY_RAUSE,6.64717694109104,-2.35799208108395,0.642389013270856,-3.67066066257539,0.00024192434671095,0.0122460569559645,intermediate,sup,https://www.uniprot.org/uniprot/Q70PR7,function:Acetyltransferase that catalyzes the formation of vinorine; a precursor of the antiarrhythmic monoterpenoid indole alkaloid ajmaline. Acts on gardneral; but not on polyneuridine aldehyde or N-methylgardneral.|catalytic activity:16-epivellosimine + acetyl-CoA = CoA + vinorine|activity regulation:Complete inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF); N-tosyl-L-phenylalanine chloromethylketone (TPCK); Hg(2+) and diethyl-pyrocarbonate (DEPC) (PubMed:15110860). 50% inhibition by N-(N-(L-3-trans-carboxirane-2-carbonyl)-L-leucyl)-agmanitine (E-64); N-alpha-p-tosyl-L-lysine chloromethylketone (TLCK) and phenylmethylsulfonyl fluoride (PMSF) (PubMed:15110860).|biophysicochemical properties:57 uM for Acetyl-CoA|biophysicochemical properties:7.5 uM for gardneral|biophysicochemical properties:63 uM for CoA|biophysicochemical properties:10 uM for vinorine|biophysicochemical properties:3.9 umol/min/mg enzyme for the forward reaction|biophysicochemical properties:44.1 umol/min/mg enzyme for the reverse reaction|biophysicochemical properties:Except vinorine; no other acetylated alkaloids are deacetylated by the reverse reaction.|biophysicochemical properties:Optimum pH is 7.8.|biophysicochemical properties:Optimum temperature is 35 degrees Celsius.|subunit:Monomer.|similarity:Belongs to the plant acyltransferase family.
Cluster-41075.1,TIC32_ARATH,11.1831164786117,-3.63407789396242,1.20012380812737,-3.02808582693891,0.00246108178642197,0.0692873359759522,intermediate,sup,https://www.uniprot.org/uniprot/Q8L9T6,function:Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32; TIC 55 and TIC62.|subunit:Part of the Tic complex. Interacts with TIC110.|subcellular location:Plastid|subcellular location:Chloroplast inner membrane|alternative products:A2RVM0-1|alternative products:1|alternative products:A2RVM0-2|alternative products:2|alternative products:A2RVM0-3|alternative products:3|tissue specificity:Expressed in leaves and roots.|disruption phenotype:Embryo lethal.|similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Cluster-43129.0,CEPR1_ARATH,135.540184571049,-1.39780617616762,0.477190295120694,-2.92924267417064,0.0033978902644351,0.0855750179833536,intermediate,sup,https://www.uniprot.org/uniprot/Q8GY29,function:Receptor kinase involved in the perception of C-terminally encoded plant signaling peptide (CEP) and subsequent regulation of root and shoot development (PubMed:25324386). Required for xylem and phloem cell files morphology and organization; probably by preventing ectopic lignification in phloem cells (PubMed:21853254). Together with CEPR2; mediates systemic nitrogen (N)-demand signaling upon the perception of root-derived peptides (e.g. CEP1) via the up-regulation of genes involved in N uptake and assimilation pathways (PubMed:25324386). Regulates positively lateral root initiation and development; probably repressed by the signaling peptide CEP5 (PubMed:27296247).|catalytic activity:ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]|subunit:Interacts with the root-derived peptides CEP1; CEP3 and CEP5.|subcellular location:Cell membrane|subcellular location:Single-pass membrane protein|tissue specificity:Expressed in the vasculature; especially in phloem and procambium regions; of stems; leaves; cotyledons; sepals; pedals; pedicels; hypocotyls and roots (in primary and lateral roots; but not in root tips) (PubMed:21853254; PubMed:25324386). Expressed in the root from the basal meristem onward. Present in the phloem pole pericycle and in the adjacent phloem (PubMed:27296247).|developmental stage:Expressed in the vasculature; especially in phloem and procambium regions; from the mature embryo stage through the adult plant (PubMed:21853254). Excluded from early stages of lateral root development (PubMed:27296247).|disruption phenotype:Defects in vascular organization and phloem differentiation in inflorescence stems; characterized by aberrant accumulation of highly lignified cells; typical of xylem or fiber cells; within the phloem; and phloem cells sometimes adjacent to xylem cells. Malformed vascular cells files; probably due to defects in oriented cell divisions or cell morphology; and leading to both phloem specification defects and disrupted xylem vessel formation. Short inflorescence stems and increased anthocyanin accumulation in leaves (PubMed:21853254). Reduced total lateral root density; due to a reduction in stage I and II lateral root primordia and; to a lower extent; to fewer emerged lateral roots. Impaired sensitivity to CEP5 with respect to root growth regulation (PubMed:27296247). Growth retardation accompanied with nitrogen (N)-deficiency symptoms. Slight enhanced lateral root elongation in simple mutant. The double mutant cepr1 cepr2 is insensitive to CEP1 in a root growth regulation and exhibit pleiotropic phenotype characterized by pale-green leaves and enhanced lateral root elongation. At adult stage; smaller rosette leaves and shorter floral stems; accompanied by anthocyanin accumulation. Down-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1; NRT2.1 and NRT3.1) leading to impaired nitrate uptake activity. Altered systemic induction of genes involved in N uptake and assimilation pathways in N-depletion conditions (PubMed:25324386).|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-43807.0,Y1648_ARATH,21.535313973816,-3.2682049861525,1.06086202399653,-3.08070692722166,0.00206509804144426,0.0607920754510986,intermediate,sup,https://www.uniprot.org/uniprot/Q9C708,alternative products:Q6NLC8-1|alternative products:1|alternative products:Q6NLC8-2|alternative products:2
Cluster-44233.1,TSJT1_TOBAC,490.156855103181,-1.39823672865773,0.487450282996449,-2.86847044187256,0.00412461736127241,0.0977050961024536,intermediate,sup,https://www.uniprot.org/uniprot/P24805,tissue specificity:Stem-specific (active at lower levels in other organs).
Cluster-47227.0,NA,189.873127003611,-2.58111908545511,0.295542717554014,-8.7334890428602,2.46934650522397E-18,3.80705917866596E-15,intermediate,sup,NA,NA
Cluster-47354.1,FTCD_MOUSE,425.915562767127,-1.37286082194856,0.336787017003056,-4.07634722432338,4.57486892320128E-05,0.00349407054459411,intermediate,sup,https://www.uniprot.org/uniprot/Q91XD4,function:Folate-dependent enzyme; that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).|function:Binds and promotes bundling of vimentin filaments originating from the Golgi.|catalytic activity:5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5;6;7;8-tetrahydrofolate + N-formimidoyl-L-glutamate|catalytic activity:5-formyltetrahydrofolate + L-glutamate = (6S)-5;6;7;8-tetrahydrofolate + H(+) + N-formyl-L-glutamate|catalytic activity:5-formimidoyltetrahydrofolate + 2 H(+) = 5;10-methenyltetrahydrofolate + NH4(+)|pathway:Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.|pathway:One-carbon metabolism; tetrahydrofolate interconversion.|subunit:Homooctamer; including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers; and form a planar ring-shaped structure (By similarity).|subcellular location:More abundantly located around the mother centriole.|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Microtubule organizing center|subcellular location:Centrosome|subcellular location:Centriole|subcellular location:Golgi apparatus|similarity:In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|similarity:In the N-terminal section; belongs to the formiminotransferase family.
Cluster-49852.0,NA,15.864493569246,-2.46805670353802,0.741380111469831,-3.32900311912191,0.00087157428284714,0.0319058911679549,intermediate,sup,NA,NA
Cluster-53434.0,PAE11_ARATH,89.0699356794373,-4.37450495986775,1.30053891328655,-3.36360943542481,0.00076930329062649,0.0293119510550274,intermediate,sup,https://www.uniprot.org/uniprot/Q93ZX9,function:Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall; galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.|subcellular location:Secreted|subcellular location:Cell wall|alternative products:Q9FH82-1|alternative products:1|alternative products:Q9FH82-2|alternative products:2|disruption phenotype:No visible phenotype under normal growth conditions.|similarity:Belongs to the pectinacetylesterase family.
Cluster-54202.1,NA,45.2253513976378,-1.2348745112931,0.361072626922003,-3.4200169694942,0.00062617229508215,0.0252811852985166,intermediate,sup,NA,NA
Cluster-56494.0,P2A01_ARATH,563.974971982691,-1.1869700102789,0.364405913219205,-3.257274284583,0.00112487680530184,0.0386705097659377,intermediate,sup,https://www.uniprot.org/uniprot/Q8LDY2,tissue specificity:Vascular tissues; specifically in phloem companion cell-sieve element complexes.
Cluster-631.1,AHP1_ARATH,8.9150004245257,-1.79801596386751,0.608166874963923,-2.95645165477678,0.00311201014038399,0.0816256569780129,intermediate,sup,https://www.uniprot.org/uniprot/Q9ZNV9,function:Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.|subunit:Interacts with the B-type response regulators ARR1; ARR2; ARR4 and ARR9. Binds to ETR1; AHK2; AHK3; AHK4; AHK5 and FBR12.|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Nucleus|tissue specificity:Strongly expressed in roots.|induction:By salt; cold and drought stress.|domain:Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.|PTM:Two-component system major event consists of a His-to-Asp phosphorelay between a sensor histidine kinase (HK) and a response regulator (RR). In plants; the His-to-Asp phosphorelay involves an additional intermediate named Histidine-containing phosphotransfer protein (HPt). This multistep phosphorelay consists of a His-Asp-His-Asp sequential transfer of a phosphate group between first an His and an Asp of the HK protein; followed by the transfer to a conserved His of the HPt protein and finally the transfer to an Asp in the receiver domain of the RR protein.
Cluster-1145.0,14334_SOLLC,16.9675211601364,-4.91287805735529,1.54999042253193,-3.16961833178945,0.00152639291550263,0.0487176416746898,intermediate,sup,https://www.uniprot.org/uniprot/Q8L5E2,subunit:Homodimer.|similarity:Belongs to the 14-3-3 family.
Cluster-2741.5,GP108_HUMAN,4.67410184749322,-2.57006033310254,0.746891764120596,-3.44100772904971,0.00057955197776891,0.0239082932216752,intermediate,sup,https://www.uniprot.org/uniprot/B9EJD7,function:May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.|function:(Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.|subcellular location:Colocalizes with TLR3; -7; -4; and -9.|subcellular location:Golgi apparatus|subcellular location:Cis-Golgi network membrane|subcellular location:Multi-pass membrane protein|subcellular location:Golgi apparatus|subcellular location:Trans-Golgi network membrane|subcellular location:Multi-pass membrane protein|subcellular location:Golgi apparatus membrane|subcellular location:Multi-pass membrane protein|domain:(Microbial infection) N- and C-terminal domains are required for AAV transduction.|similarity:Belongs to the LU7TM family.
Cluster-3513.0,DHAS_BACSU,6.15052119212439,-6.16041830833908,1.66758721973211,-3.69421055489302,0.00022057098061477,0.0114128544423562,intermediate,sup,https://www.uniprot.org/uniprot/Q04797,function:Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|catalytic activity:L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH|pathway:Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.|pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.|pathway:Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.|subunit:Homodimer.|similarity:Belongs to the aspartate-semialdehyde dehydrogenase family.
Cluster-3513.1,DHAS_BACSU,12.9043356803489,-6.62495496928111,1.24887175520754,-5.30475202250063,1.12826266405019E-07,2.34315426278533E-05,intermediate,sup,https://www.uniprot.org/uniprot/Q04797,function:Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|catalytic activity:L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH|pathway:Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.|pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.|pathway:Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.|subunit:Homodimer.|similarity:Belongs to the aspartate-semialdehyde dehydrogenase family.
Cluster-4294.0,SWET7_ARATH,7.17702340095997,-2.5989318127278,0.876774769165144,-2.96419548569181,0.0030347543384065,0.0801539950303341,intermediate,sup,https://www.uniprot.org/uniprot/Q9SN64,function:Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.|subunit:Forms heterooligomers with SWEET8; SWEET11; SWEET13; SWEET16 and SWEET17.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|induction:Induced by the pathogenic bacteria P.syringae pv. tomato.|similarity:Belongs to the SWEET sugar transporter family.
Cluster-5760.0,NA,124.896878722582,-2.06133722952062,0.658941777918295,-3.12825396506611,0.00175848165211655,0.0537489134816793,intermediate,sup,NA,NA
Cluster-6703.1,NA,12.2797285092129,-34.6624392344278,2.41400077392247,-14.3589180288892,9.3678218338952E-47,2.84041725825536E-42,intermediate,sup,NA,NA
Cluster-15213.3,ADH2_SOLTU,69.4168041621359,-1.56840813283862,0.527332170405492,-2.97423184258338,0.00293723057962095,0.0783976834548301,intermediate,sup,https://www.uniprot.org/uniprot/P14674,catalytic activity:a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH|catalytic activity:a secondary alcohol + NAD(+) = a ketone + H(+) + NADH|cofactor:Binds 2 Zn(2+) ions per subunit.|cofactor:Zn(2+)|subunit:Homodimer (By similarity). Homotetramer.|subcellular location:Cytoplasm|similarity:Belongs to the zinc-containing alcohol dehydrogenase family.
Cluster-16431.0,NA,7.52134442957954,-2.14432583205811,0.601517553346183,-3.56485994486683,0.00036405053397303,0.0169560310915458,intermediate,sup,NA,NA
Cluster-17828.0,ERF61_ARATH,11.5417677215093,-2.83738332215691,0.609589918554172,-4.65457717687758,3.24646221145682E-06,0.00039532522374932,intermediate,sup,https://www.uniprot.org/uniprot/Q9C7W2,function:Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).|subcellular location:Nucleus|similarity:Belongs to the AP2/ERF transcription factor family. ERF subfamily.
Cluster-20188.1,PP2B8_ARATH,19.2601143381799,-1.86053372057714,0.512607454739879,-3.6295486992503,0.00028391716576813,0.0139298582253327,intermediate,sup,https://www.uniprot.org/uniprot/Q9ZVQ8,NA
Cluster-20287.0,NA,8.06764975508317,-1.93330300148383,0.565742681510295,-3.41728327147375,0.00063249431149394,0.0253918902398258,intermediate,sup,NA,NA
Cluster-21500.1,KINX_DICDI,16.4609644979824,-2.36151405877321,0.705594793690782,-3.3468416715786,0.00081737880807858,0.0303722338722436,intermediate,sup,https://www.uniprot.org/uniprot/Q54QZ4,catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Cluster-21500.5,NA,793.209059955683,-1.82169065951994,0.590837365195986,-3.08323536531185,0.0020476313648092,0.0605128953337035,intermediate,sup,NA,NA
Cluster-21500.6,NA,541.304037504135,-1.82761440730829,0.413982825452511,-4.41471069557195,1.01145163196313E-05,0.00105389089115994,intermediate,sup,NA,NA
Cluster-22449.2,NA,14.8033043884073,-1.08940789165272,0.367215139703494,-2.96667477417287,0.00301039208887737,0.0796875931210743,intermediate,sup,NA,NA
Cluster-24328.0,NA,9.94031392077512,-1.95236797892368,0.562786363367742,-3.46911031610754,0.0005221849900286,0.0222375998351928,intermediate,sup,NA,NA
Cluster-24398.0,NA,15.5559401965883,-2.85121832291747,0.77375291383671,-3.68492095077161,0.00022877363243049,0.0117173062650763,intermediate,sup,NA,NA
Cluster-24752.0,NA,6.91056987734243,-3.04340687508029,0.71768033237391,-4.24061624346517,2.22906958264773E-05,0.00198204160749155,intermediate,sup,NA,NA
Cluster-25403.0,PR4_PHAVU,7.91105814821029,-1.85947902462901,0.631885792615034,-2.94274542387419,0.00325315813770344,0.0837343021165586,intermediate,sup,https://www.uniprot.org/uniprot/Q09020,tissue specificity:Abundant in radicals and epicotyls of seedlings and higher in the roots than in stems and leaves of mature plants.|developmental stage:Higher levels in seedlings than in mature plants.|induction:By wounding.
Cluster-26161.0,NA,424.840780929216,-1.6420620036453,0.413811731043624,-3.96813787638175,7.24364234653905E-05,0.00488410015865287,intermediate,sup,NA,NA
Cluster-27024.0,PIP27_ARATH,70.7154527159779,-2.12381400914263,0.59872973256481,-3.54719983596729,0.00038934914062498,0.0178061165805284,intermediate,sup,https://www.uniprot.org/uniprot/O49616,function:Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition.|subunit:Interacts with SYP61 and SYP121 in trafficking vesicles and at the plasma membrane.|subcellular location:Trafficking from the post-Golgi compartment to the plasma membrane is mediated by the SNARE proteins SYP61 and SYP121.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in flowers; expressed at low levels in siliques; and at low level in leaves and roots (PubMed:10102577; PubMed:11806824). Highly levels in elongating cells in both roots and shoots (PubMed:25082856).|induction:By NaCl and abscisic acid (ABA) treatments.|domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
Cluster-27024.3,PIP27_ARATH,45.1177333532303,-2.06901896775094,0.539330429716932,-3.83627337481564,0.0001249153569291,0.00741205193238259,intermediate,sup,https://www.uniprot.org/uniprot/O49616,function:Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition.|subunit:Interacts with SYP61 and SYP121 in trafficking vesicles and at the plasma membrane.|subcellular location:Trafficking from the post-Golgi compartment to the plasma membrane is mediated by the SNARE proteins SYP61 and SYP121.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in flowers; expressed at low levels in siliques; and at low level in leaves and roots (PubMed:10102577; PubMed:11806824). Highly levels in elongating cells in both roots and shoots (PubMed:25082856).|induction:By NaCl and abscisic acid (ABA) treatments.|domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
Cluster-27350.2,NA,313.210179717188,-1.20225195003416,0.407036778750433,-2.95366908544472,0.00314020529797118,0.0820104778981777,intermediate,sup,NA,NA
Cluster-27925.0,NA,38.3396869688914,-1.97115131825073,0.338846660594906,-5.81723696137367,5.98283018644153E-09,1.64765136462742E-06,intermediate,sup,NA,NA
Cluster-28352.0,NA,4.31333955810102,-4.99724607295803,1.10563381736098,-4.51980212118137,6.18974581058257E-06,0.00069254347868145,intermediate,sup,NA,NA
Cluster-28388.0,NA,122.227021546578,-2.27623081011133,0.654591202811151,-3.47733180699042,0.00050643067373151,0.0216885770882696,intermediate,sup,NA,NA
Cluster-29342.6,VILI3_ARATH,4.71113312188415,-4.40149689976679,1.15246655892729,-3.81919706534798,0.00013388677199573,0.0078521872605079,intermediate,sup,https://www.uniprot.org/uniprot/Q9SCN1,function:Binds actin and actin filament bundles in a Ca(2+)-insensitive manner; but severs actin filaments in a calcium-dependent manner; regardless of the presence or not of VLN1 (AC O81643). Acts redundantly with VLN2 (AC O81644) to generate thick actin filament bundles; to regulate directional organ growth (PubMed:22209875) and in sclerenchyma development (PubMed:22563899).|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|tissue specificity:Expressed in all tissues examined; including root hairs.|domain:The HP domain is important for the localization to actin filament bundles.|disruption phenotype:No visible phenotype. Vln2 and vln3 double mutants show absence of thick actin filament bundles in the cells; anomaly in the growth direction of organs (PubMed:22209875) and defects in sclerenchyma development; but no alterations in the secondary cell-wall machinery (PubMed:22563899).|similarity:Belongs to the villin/gelsolin family.
Cluster-29817.0,NA,6.08635750486931,-5.64800379739844,1.40505842225853,-4.0197643798467,5.82563747927714E-05,0.00414645901429958,intermediate,sup,NA,NA
Cluster-30434.0,PIN2_ARATH,21.6147532235487,-1.93886105104999,0.477852315328102,-4.057448271897,4.96118010172351E-05,0.00372346390753363,intermediate,sup,https://www.uniprot.org/uniprot/Q9SYT2,function:Acts as a component of the auxin efflux carrier. Seems to be involved in the root-specific auxin transport; and mediates the root gravitropism. Its particular localization suggest a role in the translocation of auxin towards the elongation zone.|subunit:Interacts with FYPP1 AND FYPP3.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Root-specific. Localized to the cortex; epidermis and lateral root cap; predominantly at the upper side of cells.|induction:Down-regulated by endoplasmic reticulum stress treatment.|disruption phenotype:Loss-of-function mutations impair the root gravitropic response; lead to an increased sensitivity to ethylene and auxin transport inhibitors; and give rise to an auxin accumulation in root tips.|similarity:Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
Cluster-31000.0,PIN2_ORYSJ,30.0430371308091,-2.13611855809624,0.550853697599518,-3.87783283910939,0.00010539108816366,0.00652155751879672,intermediate,sup,https://www.uniprot.org/uniprot/Q0DAE1,function:Acts as a component of the auxin efflux carrier. Involved in the basipetal polar auxin transport which contributes to the spreading growth of the tillers.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in roots; leaves; shoot apex and panicles (Ref.5). Expressed in roots; stem bases and young panicles (PubMed:19825657).|miscellaneous:Plants over-expressing PIN2 exhibit reduced height; increased tiller number and enlarged tiller angle.|similarity:Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
Cluster-31030.0,CCR1_ARATH,340.762620728338,-1.16342841537756,0.361302527890458,-3.22009486667719,0.00128148181878978,0.0424653663688798,intermediate,sup,https://www.uniprot.org/uniprot/Q9FPM0,function:Involved in the latter stages of lignin biosynthesis. Catalyzes one of the last steps of monolignol biosynthesis; the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes.|catalytic activity:(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH|biophysicochemical properties:0.96 uM for feruloyl-CoA|biophysicochemical properties:2.27 uM for p-coumaroyl-CoA|biophysicochemical properties:6.32 uM for sinapoyl-CoA|biophysicochemical properties:12.5 uM for caffeoyl-CoA|pathway:Aromatic compound metabolism; phenylpropanoid biosynthesis.|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9S9N9-1|alternative products:1|tissue specificity:Expressed in leaves; stems and flowers.|disruption phenotype:Dwarf phenotype; delayed senescence; collapsed xylem and significant reduction of lignin content in ecotype Columbia (PubMed:19674336). Retarded growth; impaired upright growth; altered leaf morphology; dark green leaves; collapsed xylem and strong decrease in lignin content in ecotype Landsberg erecta (PubMed:11389761).|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Cluster-31115.0,NA,19.7903782405609,-1.49858838625237,0.510651885918751,-2.93465749873057,0.00333916041928459,0.0851512220985162,intermediate,sup,NA,NA
Cluster-31349.0,MSL7_ARATH,42.1917397567782,-2.03584655170603,0.326484694484883,-6.23565694225917,4.49886052202515E-10,1.43589420935078E-07,intermediate,sup,https://www.uniprot.org/uniprot/F4IME1,function:Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|developmental stage:Expressed during somatic embryogenesis.|similarity:Belongs to the MscS (TC 1.A.23) family.
Cluster-31653.1,NA,72.7492971218961,-1.71885398455261,0.353449509531308,-4.86308210423575,1.15571878824161E-06,0.00016847379508785,intermediate,sup,NA,NA
Cluster-32109.0,NA,166.624683589775,-1.59910215705224,0.426217599826047,-3.75184449845545,0.00017553833486864,0.0096791019990097,intermediate,sup,NA,NA
Cluster-33649.0,C76A2_SOLME,4.43724036292923,-4.56341542366479,1.32434427771599,-3.44579238227616,0.00056938763425369,0.0235209842754855,intermediate,sup,https://www.uniprot.org/uniprot/P37122,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-33984.0,ALDO4_ARATH,15.4777945034045,-2.65478920075308,0.679649966454281,-3.90611245756849,9.37928745128612E-05,0.0059495685106788,intermediate,sup,https://www.uniprot.org/uniprot/Q7GB29,function:Aldehyde oxidase with a broad substrate specificity (PubMed:28188272). Involved in the accumulation of benzoic acid (BA) in siliques (PubMed:19297586). Delays and protects siliques from senescence by catalyzing aldehyde detoxification in siliques. Catalyzes the oxidation of an array of aromatic and aliphatic aldehydes; including vanillin and the reactive carbonyl species (RCS) acrolein; 4-hydroxyl-2-nonenal (HNE); and malondialdehyde (MDA) (PubMed:28188272).|catalytic activity:H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2|catalytic activity:an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2|catalytic activity:benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2|catalytic activity:H2O + hexanal + O2 = H(+) + H2O2 + hexanoate|catalytic activity:1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2|catalytic activity:H2O + O2 + vanillin = 4-hydroxy-3-methoxybenzoate + H(+) + H2O2|catalytic activity:H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2|catalytic activity:citral + H2O + O2 = 3;7-dimethylocta-2;6-dienoate + H(+) + H2O2|catalytic activity:acrolein + H2O + O2 = acrylate + H(+) + H2O2|catalytic activity:(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2|catalytic activity:(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2|catalytic activity:H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate|catalytic activity:H2O + O2 + propanal = H(+) + H2O2 + propanoate|catalytic activity:dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2|catalytic activity:H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate|cofactor:Binds 2 [2Fe-2S] clusters.|cofactor:[2Fe-2S] cluster|cofactor:FAD|cofactor:Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|cofactor:Mo-molybdopterin|activity regulation:Inhibited by Cu(2+).|biophysicochemical properties:23 uM for benzoic acid (BA) (at pH7; in the presence of NAD(+))|biophysicochemical properties:2.07 uM for indole-3-acetaldehyde (at pH7)|biophysicochemical properties:103.9 uM for cinnamylaldehyde (at pH7)|biophysicochemical properties:1.2 nmol/sec/mg enzyme with benzoic acid (BA) as substrate (at pH7; in the presence of NAD(+))|biophysicochemical properties:1.5 nmol/sec/mg enzyme with indole-3-acetaldehyde as substrate (at pH7)|biophysicochemical properties:5.5 nmol/sec/mg enzyme with cinnamylaldehyde as substrate (at pH7)|biophysicochemical properties:kcat is 95.2 sec(-1) with benzoic acid (BA) as substrate; 1.904 sec(-1) with indole-3-acetaldehyde as substrate; and 436.5 sec(-1) with cinnamylaldehyde as substrate (at pH 7; PubMed:19297586).|biophysicochemical properties:Optimum pH is 7.|biophysicochemical properties:Optimum temperature is 30 degrees Celsius.|subunit:Aldehyde oxidases (AO) are homodimers and heterodimers of AO subunits.|subcellular location:Cytoplasm|tissue specificity:Transcripts expressed at high levels in developing siliques and at low levels in dry seeds.|induction:Induced by dehydration; in rosette leaves but not in roots (PubMed:10972874; PubMed:28188272). Induced by hydrogen peroxide H(2)O(2) and aldehyde treatment (PubMed:28188272).|disruption phenotype:Plants have normal abscisic acid (ABA) levels; normal germination and are not affected in abscisic aldehyde oxidase activity in siliques; dry seeds and leaves. Reduced levels of benzoic acid (BA); 3-benzoyloxypropylglucosinolate and 4-benzoyloxybutylglucosinolate in seeds. Senesced siliques accumulate high endogenous reactive carbonyl species (RCS) levels associated with enhanced senescence molecular markers; have an increased chlorophyll degradation; and exhibit early seed shattering. Severe tissue damage and enhanced malondialdehyde levels and senescence symptoms in siliques treated with several aldehydes. Increased endogenous reactive carbonyl species (RCS) and higher expression levels of senescence marker genes; leading to premature siliques senescence in response to abiotic stresses such as dark and ultraviolet C irradiation (PubMed:28188272).|similarity:Belongs to the xanthine dehydrogenase family.
Cluster-34242.0,NA,16.5300839728688,-1.23284901568614,0.429604998642213,-2.86972688768197,0.00410826474703481,0.0975930279929641,intermediate,sup,NA,NA
Cluster-35333.0,ATAD1_RAT,10.7414640443602,-1.25381149848631,0.433604158568809,-2.89160395191952,0.00383280772359792,0.0929137464786411,intermediate,sup,https://www.uniprot.org/uniprot/B3STU2,function:Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR); thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).|catalytic activity:[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate|biophysicochemical properties:43.4 mM for ATP|biophysicochemical properties:11.0 nM/min/mg enzyme|subcellular location:Mitochondrion outer membrane|subcellular location:Single-pass membrane protein|subcellular location:Peroxisome membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell junction|subcellular location:Synapse|subcellular location:Postsynaptic cell membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the AAA ATPase family. MSP1 subfamily.|sequence caution:Truncated N-terminus.
Cluster-35443.0,NA,14.9715068630131,-1.12712976751855,0.320626488451775,-3.51539815989996,0.00043909513200554,0.0195503722430838,intermediate,sup,NA,NA
Cluster-36270.0,RADL6_ARATH,149.683506833306,-1.20800987467923,0.371558170586204,-3.25119986669479,0.00114919039308095,0.0392136886634876,intermediate,sup,https://www.uniprot.org/uniprot/Q9FRL6,function:Probable transcription factor.|subcellular location:Nucleus|alternative products:Q1A173-1|alternative products:1|alternative products:Q1A173-2|alternative products:2|tissue specificity:Expressed in the micropylar endosperm surrounding globular-stage embryos but no expression was detected elsewhere; including floral tissues.|miscellaneous:Assigned as a member of the MYB-related gene family; I-box-binding-like subfamily.|miscellaneous:Isoform 2|miscellaneous:May be due to an intron retention.
Cluster-36371.0,NA,947.170431211879,-1.4776249356885,0.501827975939437,-2.94448497599669,0.00323492651952484,0.0835939240438118,intermediate,sup,NA,NA
Cluster-36644.0,NA,20.6687826122589,-1.86987874730045,0.501953234187773,-3.72520509869044,0.00019515648308172,0.0104546638224754,intermediate,sup,NA,NA
Cluster-36835.0,KNAT6_ARATH,33.9200223403259,-1.78957347045586,0.349677537792764,-5.11778217655048,3.09149340300059E-07,5.3871937627805E-05,intermediate,sup,https://www.uniprot.org/uniprot/Q9LR21,function:Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1; CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated; meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.|subunit:May form heterodimeric complex with the TALE/BELL protein BLH9/PNY. Interacts with OFP2 and OFP4.|subcellular location:Nucleus|alternative products:Q84JS6-1|alternative products:KNAT6S|alternative products:short|alternative products:Q84JS6-2|alternative products:KNAT6L|alternative products:long|tissue specificity:Expressed predominantly in shoot apices of seedlings; and; to a lower extent; in rosette leaves.|developmental stage:First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem; and between the cotyledons. In seedlings; localized in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots.|induction:Seems to be repressed by AS2 and AS1 but induced by STM; CUC1 and CUC2.|similarity:Belongs to the TALE/KNOX homeobox family.|caution:It is uncertain whether Met-1 or Met-4 is the initiator.|sequence caution:Truncated N-terminus.|sequence caution:Truncated N-terminus.
Cluster-37151.0,NRAM6_ARATH,368.044170134026,-1.81349451859844,0.63051149904616,-2.87622750947746,0.00402459516121174,0.096200776309193,intermediate,sup,https://www.uniprot.org/uniprot/Q9C5V8,function:Probable intracellular cadmium (Cd) transporter that participates in the distribution or availability of Cd within the cell.|subcellular location:Endomembrane system|subcellular location:Multi-pass membrane protein|alternative products:Q9S9N8-1|alternative products:1|alternative products:Nramp6a|alternative products:Q9S9N8-2|alternative products:2|alternative products:Nramp6b|tissue specificity:Expressed in the vascular bundles of shoots; cotyledons; young leaves; sepals and petals; at the top of the flower stem and in the style. Expressed in the peduncle of developing siliques as well as in the septum and the funiculi.|disruption phenotype:No visible phenotype under normal growth condition; but in presence of Cd; increased tolerance to Cd toxicity.|similarity:Belongs to the NRAMP (TC 2.A.55) family.
Cluster-37411.0,CK1_ARATH,7.10442473347697,-2.39320403600038,0.782507594528206,-3.05837803075036,0.00222538649194728,0.0645702811696972,intermediate,sup,https://www.uniprot.org/uniprot/Q9C9J3,function:Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).|catalytic activity:ATP + choline = ADP + H(+) + phosphocholine|pathway:Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.|tissue specificity:Expressed in roots. Expressed at low levels in cauline leaves and flowers.|induction:By wounding; and salt and osmotic stresses.|similarity:Belongs to the choline/ethanolamine kinase family.
Cluster-37720.0,NA,11.1191220221322,-1.79687212510158,0.505646655958968,-3.55361219920218,0.00037997907362354,0.0174565840777871,intermediate,sup,NA,NA
Cluster-38323.0,PBL19_ARATH,13.1048128294038,-1.45731868743948,0.43799184379955,-3.32727357385775,0.00087700228574822,0.0319610412333797,intermediate,sup,https://www.uniprot.org/uniprot/Q9LTC0,function:May be involved in plant defense signaling.|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Cell membrane|subcellular location:Lipid-anchor|induction:Induced by infection with the bacterial pathogen Pseudomonas syringae pv maculicola strain ES4326.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-39607.0,ZPR3_ARATH,9.33078716655032,-1.62502577692288,0.460583694974588,-3.5281878074571,0.00041841517868531,0.0189072528061363,intermediate,sup,https://www.uniprot.org/uniprot/Q9LXI8,function:Competitive inhibitor of the HD-ZIPIII transcription factors in shoot apical meristem (SAM) development. Acts by forming non-functional heterodimers. Part of a negative feedback loop. Involved in SAM development and lateral organ patterning. Essential for proper functioning of stem cells in the SAM.|subunit:Interacts with REV (PubMed:18055602; PubMed:18408069). Interacts with ATBH-8; ATBH-9; ATB-14 and ATB-15 (PubMed:18408069).|subcellular location:Nucleus|tissue specificity:Expressed in the adaxial epidermis of the cotyledons and leaves; and in the vascular cylinder of wild-type torpedo stage embryos. Confined in the central zone and the organizing center in the shoot apical meristem.|induction:Up-regulated in response to increased HD-ZIPIII activity (PubMed:18055602). Up-regulated by ATHB-14 (PubMed:18408069). Up-regulated by REV (PubMed:22781836).|disruption phenotype:No visible phenotype during the vegetative growth. Disrupted activities of the shoot apical meristem and/or axillary meristems after the transition to reproductive growth. Zpr3 and zpr4 double mutants exhibit homeotic transformation and ectopic meristem activity.
Cluster-39710.0,CALM3_PETHY,60.7337169314369,-1.53859943493328,0.32753790552106,-4.69746984699563,2.63404055419147E-06,0.00033841840526965,intermediate,sup,https://www.uniprot.org/uniprot/P27164,function:Calmodulin mediates the control of a large number of enzymes; ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.|miscellaneous:This protein has four functional calcium-binding sites.|similarity:Belongs to the calmodulin family.
Cluster-40899.1,CNGC2_ARATH,232.413400325689,-1.47848217489112,0.421582819036406,-3.50697919395868,0.0004532245842509,0.0200887615485233,intermediate,sup,https://www.uniprot.org/uniprot/O65718,function:Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium; cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis; re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.|subunit:Homotetramer or heterotetramer (Potential). Binds calmodulin-1/4 with a higher affinity than calmodulin-2/3/5.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:O65718-1|alternative products:1|tissue specificity:Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques.|induction:Up-regulated by light. Transiently induced during leaf and culture senescence.|domain:The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.|miscellaneous:Loss-of-function mutations cngc2-1 (dnd1-1) or cncg2-2 results in the loss of the hypersensitive response and leads to a broad spectrum disease resistance. These mutations lead to a specific and dramatic calcium hypersensitivity that results in severe reductions in plant size and seed yield.|similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
Cluster-40909.0,KRP6_ORYSJ,58.7888505651197,-1.70480071267549,0.518117933537542,-3.29037194492701,0.00100055031050844,0.0353998669369036,intermediate,sup,https://www.uniprot.org/uniprot/Q67J15,similarity:Belongs to the CDI family. ICK/KRP subfamily.|caution:In contrast to other members of the family; it lacks the N-terminal region.
Cluster-41094.2,ADS3_ARATH,33.3364965222263,-8.64878398631,2.11852301082974,-4.08245930872501,4.45616162137349E-05,0.0034206399119409,intermediate,sup,https://www.uniprot.org/uniprot/Q9LVZ4,function:Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7;10;13-trienoic acid (16:3(7Z;10Z;13Z)); the major functional components of thylakoid membranes (PubMed:15579662; PubMed:16666902; PubMed:15240892). Required for chloroplast biogenesis at low temperature (PubMed:16668849). Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).|catalytic activity:a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]|cofactor:Fe(2+)|pathway:Lipid metabolism; oxylipin biosynthesis.|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Plastid|subcellular location:Chloroplast membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in young leaves. Low expression in roots.|domain:The histidine box domains are involved in binding the catalytic metal ions.|miscellaneous:Substrate specificity shifts from delta-7 to delta-9 desaturation when the protein is retargeted to the cytoplasm.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-41485.0,ZWIP4_ARATH,7.72983061324327,-1.67234703149731,0.528809230749439,-3.16247700352588,0.00156433090512618,0.0495352000358429,intermediate,sup,https://www.uniprot.org/uniprot/Q9LT33,function:Probable transcriptional regulator.|subcellular location:Nucleus|similarity:Belongs to the WIP C2H2-type zinc-finger protein family.|sequence caution:Truncated N-terminus.
Cluster-41744.0,RADL3_ARATH,132.580924094267,-1.09705396183719,0.344864035971044,-3.18112023118959,0.00146706730203765,0.0471524398623101,intermediate,sup,https://www.uniprot.org/uniprot/O23224,function:Probable transcription factor.|subcellular location:Nucleus|tissue specificity:Expressed just outside the vascular bundles in the rosette stem and the leaf traces. Not detected in floral primordia.|miscellaneous:Assigned as a member of the MYB-related gene family; I-box-binding-like subfamily.
Cluster-42265.0,MT1_ERYGU,1670.61871664057,-1.10564787537896,0.2332520143196,-4.74014288195602,2.13567560617303E-06,0.0002852679297567,intermediate,sup,https://www.uniprot.org/uniprot/P20238,function:Metallothioneins have a high content of cysteine residues that bind various heavy metals.|similarity:Belongs to the metallothionein superfamily. Type 15 family.
Cluster-42291.0,NA,43.7106573601447,-1.33326956821385,0.413994852498648,-3.22049793654912,0.00127968113913421,0.0424520917064424,intermediate,sup,NA,NA
Cluster-42564.8,NA,12.4672132035017,-2.89762918601573,0.673897311541378,-4.29980819983997,1.7094599153078E-05,0.00158509278568953,intermediate,sup,NA,NA
Cluster-43519.0,KASC1_ARATH,8.52986844137192,-5.54701616147359,1.44723326836817,-3.83284179732002,0.00012667142064012,0.00750157059615095,intermediate,sup,https://www.uniprot.org/uniprot/Q9FL32,function:Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).|catalytic activity:a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]|subunit:Homodimer.|subcellular location:Plastid|subcellular location:Chloroplast stroma|alternative products:P52410-1|alternative products:1|alternative products:P52410-2|alternative products:2|similarity:Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Cluster-44984.0,RH20_ORYSJ,12.0500324253577,-2.68066006186885,0.885509246892872,-3.02725247791021,0.00246787735820615,0.0693943039216598,intermediate,sup,https://www.uniprot.org/uniprot/A0A0P0UZY0,function:ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.|catalytic activity:ATP + H2O = ADP + H(+) + phosphate|subcellular location:Nucleus|domain:The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|similarity:Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Cluster-45080.0,AAE_RAUSE,25.6324666166783,-3.41549217040917,1.08613229368233,-3.14463734323706,0.00166292833530786,0.0517145128767895,intermediate,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-46016.0,PIP28_ARATH,6.08134556914139,-3.79759048562611,1.02837737148767,-3.69279856880985,0.00022179970222205,0.0114373958691751,intermediate,sup,https://www.uniprot.org/uniprot/Q0WS43,function:Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in roots and floral buds.|domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
Cluster-46257.0,NA,38.9774535098032,-4.32507610079629,0.48476591420218,-8.92198889006961,4.57988181404762E-19,8.66219057334365E-16,intermediate,sup,NA,NA
Cluster-49142.0,RAD_ANTMA,4230.27811442411,-10.8819107117792,0.787508988018118,-13.8181416051709,1.98118716223812E-43,3.00357879731111E-39,intermediate,sup,https://www.uniprot.org/uniprot/Q58FS3,function:Involved in the dorsovental asymmetry of flowers. Promotes dorsal identity.|subcellular location:Nucleus|tissue specificity:Specifically expressed in the dorsal region of developing flowers.|developmental stage:Early expressed at stage two (plastochrons 7 and 8); when the floral meristem comprised a loaf-shaped bulge of cells. Expression was in the dorsal region of the floral meristem. At stage four; when sepal primordia had emerged around the meristem dome; expression could be seen in the dorsal sepal primordium. At stage five; expressed in emerging dorsal primordia of whorls two and three. In older flower buds (stages seven and eight); expression was found mainly in the dorsal petals and staminode.|induction:Up-regulated by both CYC and DICH.|disruption phenotype:Radially symmetric flowers. Loss of functional stamens in dorsal positions. Organs reduction with five organs per whorl rather than six.
Cluster-49787.0,PM19L_ORYSJ,15.0781992517431,-1.56334119483887,0.429238934049026,-3.64212346743996,0.00027039831991897,0.0133966461736327,intermediate,sup,https://www.uniprot.org/uniprot/Q6L4D2,function:May be involved in abiotic stress response through abscisic acid-dependent signaling.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in roots; leaf blades; leaf sheaths; stems; spikelets and embryos.|induction:Induced by heat shock (PubMed:24459431). Induced by drought; cold and salt stresses (PubMed:24459431; PubMed:26505346). Induced by abscisic acid (ABA) (PubMed:24459431; PubMed:26505346).
Cluster-50283.0,NA,61.8125509903529,-2.22036819997981,0.337135182685858,-6.58598779958468,4.51870930407708E-11,1.73432638998634E-08,intermediate,sup,NA,NA
Cluster-51214.0,FBK22_ARATH,26.2776821340122,-1.63197506390827,0.531590642432613,-3.06998455887069,0.00214069838151724,0.0625569114618047,intermediate,sup,https://www.uniprot.org/uniprot/Q9C897,NA
Cluster-51306.1,NA,61.8844388658325,-1.15417826347446,0.390037122930621,-2.95914977221224,0.00308489131826311,0.0813365127487442,intermediate,sup,NA,NA
Cluster-51481.0,NA,11.2739845130471,-1.78169790006927,0.488352444379606,-3.64838534254233,0.00026389362740986,0.013129163842129,intermediate,sup,NA,NA
Cluster-52138.0,NA,244.130522501933,-1.29600071438455,0.282303957254646,-4.59079896359908,4.41552486491308E-06,0.00050713306601905,intermediate,sup,NA,NA
Cluster-52262.0,SMR6_ARATH,39.8957748113548,-1.1909450560647,0.40782563879885,-2.92023095843688,0.00349772061432759,0.0870011376103583,intermediate,sup,https://www.uniprot.org/uniprot/Q9FI64,function:Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle (By similarity). May inhibit CDKA-1/CYCD complexes during S-phase; preventing the re-initiation of DNA replication (PubMed:20706207).|subunit:Interacts with CDKA-1 and D-type cyclins (PubMed:20706207).
Cluster-52306.0,MTP3_ORYSJ,245.708741987004,-1.47170727820225,0.458426398510193,-3.21034583301713,0.0013257536284468,0.0437412141111376,intermediate,sup,https://www.uniprot.org/uniprot/Q0DX45,function:Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.|subcellular location:Tonoplast.|subcellular location:Vacuole membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Cluster-52592.0,COMT1_POPTM,11.8407209735322,-4.71335480785471,1.06970696760271,-4.40621118736626,1.05194406424186E-05,0.00108860054511528,intermediate,sup,https://www.uniprot.org/uniprot/Q43094,function:Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.|catalytic activity:(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine|pathway:Aromatic compound metabolism; phenylpropanoid biosynthesis.|subunit:Homodimer.|tissue specificity:Xylem.|PTM:The N-terminus is blocked.|similarity:Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Cluster-52993.1,DRL4_ARATH,5.81864454558733,-1.98706112868973,0.596937151700099,-3.32876103125849,0.00087233217170392,0.0319058911679549,intermediate,sup,https://www.uniprot.org/uniprot/F4I4Y9,function:Potential disease resistance protein.|domain:The LRR repeats probably act as specificity determinant of pathogen recognition.|similarity:Belongs to the disease resistance NB-LRR family.|online information:Functional and comparative genomics of disease resistance gene homologs
Cluster-53657.0,PER12_ARATH,5.29656755428854,-5.89297373383418,1.29725019225518,-4.54266553130328,5.55473475668753E-06,0.00062379671317601,intermediate,sup,https://www.uniprot.org/uniprot/Q43734,function:Removal of H(2)O(2); oxidation of toxic reductants; biosynthesis and degradation of lignin; suberization; auxin catabolism; response to environmental stresses such as wounding; pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.|function:Exhibits a Ca(2+)-pectate binding affinity which could be interpreted in vivo as a specificity to interact with the pectic structure of the cell wall.|catalytic activity:2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O|cofactor:Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|cofactor:heme b|cofactor:Binds 2 calcium ions per subunit.|cofactor:Ca(2+)|subcellular location:Carboxy-terminal extension appears to target the protein to vacuoles.|subcellular location:Secreted|subcellular location:Vacuole|tissue specificity:Expressed in roots and leaves.|developmental stage:Expressed in the first stage of developing seeds.|induction:Induced either by incompatible fungal pathogen attack; or by methyl jasmonate; a plant defense-related signaling molecule.|miscellaneous:There are 73 peroxidase genes in A.thaliana.|similarity:Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Cluster-54919.0,VESTR_MEDSA,30.3990221890309,-1.30409435103718,0.42814556852925,-3.04591346236971,0.00231974590342864,0.0662931343429403,intermediate,sup,https://www.uniprot.org/uniprot/Q40316,function:Stereospecific enzyme that catalyzes the NADPH-dependent reduction of (3R)-vestitone to (3R;4R)-4'-methoxyisoflavan-2';4;7-triol (DMI). Has no activity with (3S)-vestitone. Catalyzes the penultimate step in the biosynthesis of the phytoalexin medicarpin; and thereby contributes to plant defense reactions.|catalytic activity:a (3R;4R)-4;2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH|activity regulation:Inhibited by vestitone concentrations above 50 uM.|biophysicochemical properties:40 uM for vestitone|biophysicochemical properties:Optimum pH is 6.0.|biophysicochemical properties:Optimum temperature is 30 degrees Celsius.|subunit:Monomer.|tissue specificity:Detected in roots; and at lower levels in root nodules. Not detected in petioles; leaf and stem.|induction:Transiently up-regulated by fungal elicitors; peaking 6 hours after elicitor treatment.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Cluster-55325.0,SCL3_ARATH,20.4972500051792,-1.24329705413156,0.421426885037649,-2.95020820520381,0.0031755985030523,0.0826500619837329,intermediate,sup,https://www.uniprot.org/uniprot/Q9XE52,function:Probable transcription factor involved in plant development.|subunit:Binds to zinc finger proteins MGP/IDD3; IDD4; IDD5; BIB/IDD9 and JKD/IDD10.|subcellular location:Nucleus|tissue specificity:Expressed in seedlings; root epidermis; leaves; flowers and siliques.|similarity:Belongs to the GRAS family.
Cluster-56041.0,FLZ5_ARATH,128.677450736227,-1.7399582316589,0.583958633627198,-2.97959158656724,0.00288632930991783,0.0773796560619085,intermediate,sup,https://www.uniprot.org/uniprot/Q9LM43,subunit:Interacts with KIN10 and KIN11 via its FLZ-type zinc finger domain (PubMed:24600465; PubMed:29945970). Interacts with KINB3 via its N-terminal part (PubMed:29945970). Interacts with DELLA proteins GAI and RGA (Ref.9).|subcellular location:Shuttles from the cytoplasm to the nucleus when associated with KIN10.|subcellular location:Nucleus|subcellular location:Cytoplasm|induction:Down-regulated in response to mild as well as prolonged energy depletion (PubMed:26442059). Up-regulated by glucose; sucrose and mannose (PubMed:26442059).|similarity:Belongs to the FLZ family.
Cluster-56291.1,GDL61_ARATH,289.347421893148,-2.0690144384812,0.581432389020213,-3.55847812669629,0.00037300984771304,0.0172146599581542,intermediate,sup,https://www.uniprot.org/uniprot/Q0WNC7,subcellular location:Secreted|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-56291.6,GDL61_ARATH,145.026984554462,-1.27479545428121,0.38318809444015,-3.32681383575795,0.00087845039075275,0.0319753833109415,intermediate,sup,https://www.uniprot.org/uniprot/Q0WNC7,subcellular location:Secreted|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-56291.9,GDL61_ARATH,21.3293478185134,-4.97105337707589,1.40185117245277,-3.54606357276729,0.00039103186025112,0.0178292887739463,intermediate,sup,https://www.uniprot.org/uniprot/Q0WNC7,subcellular location:Secreted|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-56382.0,FADX_VERFO,4.28923379689267,-5.46838994362462,1.43329242946061,-3.81526465306353,0.00013603705616428,0.00794755217718156,intermediate,sup,https://www.uniprot.org/uniprot/Q8GZC2,function:Converts linoleic acid to alpha-eleostearic acid (18:3(9Z;11E;13E)) and alpha-linolenic acid to alpha-parinaric acid (18:4(9Z;11E;13E;15Z)). Converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13. Can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate; stereoselectively introducing a trans double bond.|catalytic activity:a (9Z;12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z;11E;13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O|catalytic activity:(9Z;12Z;15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z;11E;13E;15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O|catalytic activity:a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z;12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O|catalytic activity:a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z;12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed exclusively in developing seeds.|domain:The histidine box domains may contain the active site and/or be involved in metal ion binding.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-56526.0,NA,43.4671048105028,-2.78775274192008,0.402597970700416,-6.9244083299032,4.37801425785605E-12,2.04224262019159E-09,intermediate,sup,NA,NA
Cluster-56526.1,NA,28.6081547207326,-3.56278898953604,0.865188118578712,-4.11793564085093,3.82281415194083E-05,0.00299513043671829,intermediate,sup,NA,NA
Cluster-56526.2,NA,418.014203239517,-3.0281975366179,0.409395986387446,-7.3967445634703,1.39563645990254E-13,9.19936806537064E-11,intermediate,sup,NA,NA
Cluster-57115.2,SWET5_ORYSJ,6.63788573175866,-3.19262768004977,0.843819885462494,-3.78354164799032,0.00015461243858686,0.00882863229829074,intermediate,sup,https://www.uniprot.org/uniprot/A0A0P0WQZ4,function:Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Can transport galactose. Prevents growth but promotes senescence (PubMed:25988582; PubMed:24709840). Involved in regulating the crosstalk between sugar and auxin. Regulates negatively the auxin signaling pathway and translocation (PubMed:24709840).|subunit:Forms homooligomers and/or heterooligomers.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Mainly expressed in the floral organs at the heading stage; and also in stem; root; senescing leaves; stamen; pistil and hull.|similarity:Belongs to the SWEET sugar transporter family.
Cluster-57166.0,NRAM1_ARATH,68.8304039803374,-2.31606906396988,0.775844782457055,-2.98522219436087,0.00283372403924647,0.0766176637347344,intermediate,sup,https://www.uniprot.org/uniprot/Q9SP94,function:High affinity manganese (Mn) transporter involved in Mn acquisition from the soil. Required for Mn uptake into the root in conditions of low Mn availability. Can transport iron (Fe); cadmium (Cd) and cobalt (Co).|biophysicochemical properties:28 nM for Mn (2+)|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|induction:By Mn and Fe deficiency in roots.|disruption phenotype:No visible phenotype under normal growth condition; but under Mn limitation; very slow growth and unable to take up Mn.|similarity:Belongs to the NRAMP (TC 2.A.55) family.
Cluster-57253.1,TNG2_BOVIN,415.435615403742,-6.1094146128568,1.07325268989626,-5.69242888498827,1.25244769635312E-08,3.13846831414239E-06,intermediate,sup,https://www.uniprot.org/uniprot/Q29RZ5,subcellular location:Cytoplasm|subcellular location:Mitochondrion|subcellular location:Golgi apparatus|similarity:Belongs to the Tango2 family.|caution:Has been reported to be located in the Golgi apparatus (By similarity). However; another study was unable to detect Golgi localization (By similarity). Has also been reported to be located in the mitochondrion (By similarity). However; no mitochondrial localization was detected in another study which reported that the protein is primarily cytoplasmic (By similarity).
Cluster-57305.1,OTU_ARATH,22.9378380989184,-1.47660845308513,0.502145600181769,-2.94059821006223,0.00327579138529402,0.0841386949753308,intermediate,sup,https://www.uniprot.org/uniprot/Q8LBZ4,OTU domain-containing protein At3g57810 [Gene: At3g57810 or T10K17.20] - Arabidopsis thaliana (Mouse-ear cress)
Cluster-57679.1,NLTP6_AMBAR,366.654199079695,-1.48869585871743,0.469749810951281,-3.16912497676733,0.00152898634061302,0.0487491007715324,intermediate,sup,https://www.uniprot.org/uniprot/O04004,function:Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).|allergen:Causes an allergic reaction in human. Binds to IgE.|similarity:Belongs to the plant LTP family.
Cluster-631.0,AHP1_ARATH,184.880158819448,-1.52891577346441,0.378488621196743,-4.03952903162619,5.3558638622906E-05,0.00370243050872507,late,sup,https://www.uniprot.org/uniprot/Q9ZNV9,function:Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.|subunit:Interacts with the B-type response regulators ARR1; ARR2; ARR4 and ARR9. Binds to ETR1; AHK2; AHK3; AHK4; AHK5 and FBR12.|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Nucleus|tissue specificity:Strongly expressed in roots.|induction:By salt; cold and drought stress.|domain:Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.|PTM:Two-component system major event consists of a His-to-Asp phosphorelay between a sensor histidine kinase (HK) and a response regulator (RR). In plants; the His-to-Asp phosphorelay involves an additional intermediate named Histidine-containing phosphotransfer protein (HPt). This multistep phosphorelay consists of a His-Asp-His-Asp sequential transfer of a phosphate group between first an His and an Asp of the HK protein; followed by the transfer to a conserved His of the HPt protein and finally the transfer to an Asp in the receiver domain of the RR protein.
Cluster-741.13,RGP1_PEA,839.042668690525,-1.43127660707854,0.329781675251402,-4.34007318929238,1.4243526779463E-05,0.00134108933149068,late,sup,https://www.uniprot.org/uniprot/O04300,function:Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides (By similarity). Was initially shown to possess an autoglycosylating activity which is dependent on the presence of UDP-glucose and manganese (PubMed:9207152).|catalytic activity:UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose|cofactor:Mn(2+)|cofactor:Mg(2+)|activity regulation:Inhibited by inhibitor protein (IP) which may be a form of sucrose synthase.|subunit:Homopentamer or homohexamer.|subcellular location:Cell wall-associated; with highest concentrations on plasmodesmata. Also located in the Golgi apparatus.|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Cell junction|subcellular location:Plasmodesma|subcellular location:Golgi apparatus|domain:The conserved DXD motif is involved in enzyme activity.|PTM:Reversibly glycosylated by UDP-glucose; UDP-xylose and UDP-galactose; but not UDP-mannose.|similarity:Belongs to the RGP family.
Cluster-7572.1,UGT2_GARJA,586.896512284765,-1.63617405028689,0.399614783680205,-4.09437817895209,4.23302904776199E-05,0.00310912064086777,late,sup,https://www.uniprot.org/uniprot/F8WKW1,function:Iridoid glucosyltransferase acting on genipin and 7-deoxyloganetin. No activity with 7-deoxyloganetic acid. Involved in geniposide biosynthesis.|catalytic activity:7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP|biophysicochemical properties:8.82 mM for genipin|biophysicochemical properties:0.61 mM for 7-deoxyloganetin|biophysicochemical properties:0.17 mM for UPD-glucose|biophysicochemical properties:kcat is 1.04 sec(-1) for genipin. kcat is 0.13 sec(-1) for 7-deoxyloganetin. kcat is 0.16 sec(-1) for UPD-glucose.|tissue specificity:Ubiquitous. Very low expression in stems.|developmental stage:Up-regulated during the early stage of fruit ripening.|induction:Up-regulated by methyl jasmonate.|similarity:Belongs to the UDP-glycosyltransferase family.
Cluster-21091.4,CER1_ARATH,160.730581281625,-1.55395510928758,0.16120559911876,-9.63958521157061,5.44073723510379E-22,2.4662084638549E-18,late,sup,https://www.uniprot.org/uniprot/Q39045,function:Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes. Core component of a very-long-chain alkane synthesis complex. Involved in epicuticular wax biosynthesis and pollen fertility.|catalytic activity:a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)|subunit:Homodimer. Interacts with CER3; CYTB5-B; CYTB5-C; CYTB5-D and CYTB5-E.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Multi-pass membrane protein|alternative products:F4HVY0-1|alternative products:1|alternative products:F4HVY0-2|alternative products:2|alternative products:F4HVY0-3|alternative products:3|tissue specificity:Expressed in seedlings; stems; leaves; flowers; fruits and siliques. Not detected in roots; pollen and seeds. Expressed in trichomes; cotyledons; shoot apical meristem and leaf primordia. Preferentially associated with young leaves rather than mature leaves. Expressed in the epidermis of the stem and caulines leaves; in the carpels and the sepals.|induction:Down regulated by cold and dark stresses. Up-regulated by low humidity; osmotic stress and abscisic acid treatment. No effet of methyl jasmonate; GA3; salicylic acid; cytokinin or auxin treatments.|disruption phenotype:Glossy stem and fruit and reduced fertility due to the inability of the pollen grains to rehydrate on the stigma surface. Disappearance of the wax crystals. Decreased C29; C31 and C33 alkane contents. Increased susceptibility to soil water deficit.|similarity:Belongs to the sterol desaturase family.|sequence caution:Truncated C-terminus.
Cluster-26957.0,NDB4_ARATH,6.5584796599872,-3.07848164988371,0.944280294341218,-3.26013543683174,0.00111359024176571,0.038574474204395,late,sup,https://www.uniprot.org/uniprot/Q9SKT7,function:Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane (By similarity). NAD(P)H dehydrogenase; more efficient on NADH.|catalytic activity:a quinone + H(+) + NADH = a quinol + NAD(+)|catalytic activity:a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)|cofactor:Binds 1 FAD per subunit.|cofactor:FAD|activity regulation:No effect of calcium ions on activity.|biophysicochemical properties:Optimum pH is 6.8 with NADPH as substrate and 6.8-7.8 with NADH as substrate.|subcellular location:Mitochondrion inner membrane|subcellular location:Peripheral membrane protein|subcellular location:Intermembrane side|subcellular location:Peroxisome|tissue specificity:Expressed in seedlings; roots; cotyledons; stems; buds and flowers and; to a lower extent; in stems and leaves.|induction:Induced by chloramphenicol (Chl); erythromycin (Ery); paraquat (Par); rotenone (Rot) and salicylic acid (SA).|disruption phenotype:Lower reactive oxygen species formation and altered phenotype (e.g. growth rate; root:shoot ratios and leaf area). Lower leaf area early in development followed by a prompt subsequent increase in leaf area leading to larger leaves in mature plants. Better tolerance to salinity stress. These phenotypes are probably due to an enhanced expression of NDB2 and AOX.|similarity:Belongs to the NADH dehydrogenase family.
Cluster-28503.1,C94A1_VICSA,10.7559999098382,-2.76997574741794,0.864081167489425,-3.20568929359503,0.00134739391155586,0.0441753770189031,late,sup,https://www.uniprot.org/uniprot/O81117,function:Catalyzes the omega-hydroxylation of various fatty acids (FA) from 10 to 18 carbon atoms. The substrate specificity is higher for laurate > palmitate > myristate > linolenate > linoleate > oleate > caprate. May play a minor role in cutin synthesis and could be involved in plant defense.|cofactor:heme|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|induction:By clofibrate.|similarity:Belongs to the cytochrome P450 family.
Cluster-29162.0,UFC_ARATH,285.77500611708,-2.32840349268791,0.758971675828334,-3.06783977168412,0.00215612192183718,0.0620142662058049,late,sup,https://www.uniprot.org/uniprot/Q9LX14,Protein UPSTREAM OF FLC [Gene: UFC or At5g10150 or T31P16.140]- Arabidopsis thaliana (Mouse-ear cress)
Cluster-29874.0,Y3795_ARATH,63.7034388002479,-1.82916069534009,0.608764276371224,-3.00471096340199,0.0026583333499495,0.0724025040290968,late,sup,https://www.uniprot.org/uniprot/Q6E250,subunit:Interacts with RLK902.|alternative products:Q6DR24-1|alternative products:1|alternative products:Q6DR24-2|alternative products:2|tissue specificity:Expressed in inflorescences; stems; rosette leaves and weakly in roots.|induction:Rapid but transient down-regulation by wounding; salicylic acid treatment or pathogen infection.
Cluster-30348.0,PAO1_ARATH,34.3982959399496,-2.54792107256944,0.782868635966354,-3.25459592518271,0.0011355380431785,0.0390787658460452,late,sup,https://www.uniprot.org/uniprot/Q7FL79,function:Flavoenzyme involved in polyamine back-conversion (PubMed:16778015; PubMed:20532512; PubMed:21081665; PubMed:26973665). Catalyzes the oxidation of the secondary amino group of polyamines; such as spermine and its acetyl derivatives (PubMed:16778015; PubMed:20532512; PubMed:21081665). Substrate preference is thermospermine > norspermine > spermine > N(1)-acetylspermine (PubMed:16778015; PubMed:21081665). No activity detected when putrescine; spermidine or N(1)-acetylspermidine are used as substrates (PubMed:16778015). Plays an important role in the regulation of polyamine intracellular concentration (Probable) (PubMed:26973665). Involved in the production of hydrogen peroxide in response to salt and cold stresses (PubMed:26973665).|catalytic activity:H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine|catalytic activity:H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine|catalytic activity:H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine|catalytic activity:H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine|catalytic activity:H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine|cofactor:Binds 1 FAD per subunit.|cofactor:FAD|activity regulation:Inhibited by guazatine; N-prenylagmatine and 1;12-diaminododecane.|biophysicochemical properties:0.11 mM for spermine|biophysicochemical properties:0.12 mM for spermine|biophysicochemical properties:0.09 mM for norspermine|biophysicochemical properties:0.2 mM for N(1)-acetylspermine|biophysicochemical properties:0.47 mM for N(1)-acetylspermine|biophysicochemical properties:0.02 mM for thermospermine|biophysicochemical properties:Optimum pH is 8.0.|pathway:Amine and polyamine degradation; spermine degradation.|subcellular location:Cytoplasm|tissue specificity:Expressed at very low levels in leaves; stems and inflorescences.|disruption phenotype:No visible phenotype of seedlings under normal growth conditions (PubMed:26973665). The double mutants pao1 and pao5 exhibit enhanced tolerance to salt and drought stress (PubMed:26973665).|similarity:Belongs to the flavin monoamine oxidase family.
Cluster-30995.0,PDR1_NICPL,8.91508132086199,-4.05240222993907,1.02269875293384,-3.96245934427301,7.41816422777137E-05,0.00483323102560956,late,sup,https://www.uniprot.org/uniprot/Q949G3,function:Excretes secondary metabolites such as terpenes. Involved in both constitutive and jasmonic acid-dependent induced defense. Confers some resistance to sclareol and B.cinerea.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Roots; petals and leaf epidermis; where it is confined to glandular trichomes (at protein level).|induction:By terpenes such as sclareolide and sclareol; and by some phytohormones such as jasmonic acid (JA) and ethylene. Strongly induced by compatible pathogens such as the fungus B.cinerea; and the bacteria P.syringae pv tabaci; as well as by non pathogenic bacteria such as P.fluorescens; and P.marginalis pv marginalis. Weak induction by incompatible pathogens such as P.syringae pv syringae (at protein level).|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-33191.0,E70A1_ARATH,8.92968879718321,-2.5410206590778,0.867469544478258,-2.92923328000651,0.00339799296678753,0.085164547263956,late,sup,https://www.uniprot.org/uniprot/Q9LZD3,function:Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. Involved in polarized cell growth and organ morphogenesis. During cytokinesis; involved in cell plate initiation; cell plate maturation and formation of new primary cell wall. Participates in polarized pectin delivery required for the polarized development of the mucilage-producing volcano cells of the seed coat. Involved in the recycling and localization of auxin efflux carriers PIN1 and PIN2; and thus in polar auxin transport regulation. Functions in vesicle trafficking in tracheary elements to regulate patterned secondary cell wall (SCW) thickening (PubMed:27801942).|subunit:The exocyst complex is composed of SEC3; SEC5; SEC6; SEC8; SEC10; EXO70A1 and EXO84B. Interacts with SEC3A and EXO84B. Co-localizes with FPP3/VETH1; FPP2/VETH2 and COG2 in vesicle-like small motile compartments (PubMed:25541219). May interact with COG2 (PubMed:27801942).|subcellular location:During cytokinesis; localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall (PubMed:20870962). Localized at vesicle-like small compartments at cortical microtubules; especially in the presence of FPP3/VETH1; FPP2/VETH2 and COG2 (PubMed:25541219). Confined to helical/annular plasma membrane (PM) domains in protoxylem of roots before the secondary cell wall (SCW) is deposited. After the induction of xylem differentiation; first associated with plasma membrane (PM) foci and later co-localizes with microtubules (MT) organized into regular bundles; especially at the cell cortex (PubMed:27801942).|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Phragmoplast|subcellular location:Cell membrane|subcellular location:Secreted|subcellular location:Cell wall|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9LZD3-1|alternative products:1|disruption phenotype:Dwarf and sterile plants with decreased apical dominance. Branched inflorescences due to ectopic initiation of lateral inflorescences instead of flowers. Altered polar growth of root hairs and stigmatic papillae. Reduced cell expansion and aberrant xylem development. Aberrant deposition of xylem secondary cell wall (SCW) (PubMed:27801942).|similarity:Belongs to the EXO70 family.
Cluster-33627.0,WTR45_ARATH,22.1444026292822,-4.76224753772121,1.22368546774172,-3.8917251722453,9.95339542332581E-05,0.00608513322019927,late,sup,https://www.uniprot.org/uniprot/Q9FGG3,subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
Cluster-34063.0,ATAD1_RAT,43.5165729148201,-1.26032221630908,0.39584521155185,-3.18387637270685,0.00145317061046808,0.0463408075076907,late,sup,https://www.uniprot.org/uniprot/B3STU2,function:Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR); thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).|catalytic activity:[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate|biophysicochemical properties:43.4 mM for ATP|biophysicochemical properties:11.0 nM/min/mg enzyme|subcellular location:Mitochondrion outer membrane|subcellular location:Single-pass membrane protein|subcellular location:Peroxisome membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell junction|subcellular location:Synapse|subcellular location:Postsynaptic cell membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the AAA ATPase family. MSP1 subfamily.|sequence caution:Truncated N-terminus.
Cluster-34349.0,GALE2_CYATE,5.52430541491854,-4.12146055677625,1.25006174474376,-3.29700558720887,0.00097721557238139,0.0348393821479343,late,sup,https://www.uniprot.org/uniprot/O65781,catalytic activity:UDP-alpha-D-glucose = UDP-alpha-D-galactose|cofactor:NAD(+)|pathway:Carbohydrate metabolism; galactose metabolism.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Cluster-34359.0,NA,245.665505106026,-1.30583698205805,0.284168366155109,-4.59529327534394,4.32141034561565E-06,0.00051843403253741,late,sup,NA,NA
Cluster-36060.0,NLTP3_ARATH,21.1055067124692,-4.1831404417968,1.06079897546505,-3.94338657799226,8.03389959962116E-05,0.00517070252121662,late,sup,https://www.uniprot.org/uniprot/Q9FIE6,function:Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).|similarity:Belongs to the plant LTP family.
Cluster-36337.0,CAAT1_ARATH,35.3922474329613,-1.88242976928851,0.565803308995488,-3.32700381804152,0.00087785170694394,0.03227605406875,late,sup,https://www.uniprot.org/uniprot/Q96241,function:High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine; lysine; histidine; citrulline; valine; and glutamate). Transport mostly basic amino acids; and; to a lower extent neutral and acidic amino acids. May function as a proton symporter.|activity regulation:Inhibited by the protonophore 2;4-dinitrophenol.|biophysicochemical properties:35 uM for histidine (at pH 4.5)|biophysicochemical properties:Optimal transport of histidine at pH 4.5-5.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed in roots; stems; flowers; petioles; seeds; siliques; and leaves. Mostly present in major veins.|similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|sequence caution:Truncated N-terminus.|sequence caution:Truncated N-terminus.
Cluster-38175.3,ATH1_ARATH,180.136405351157,-1.02294426889186,0.292763700700335,-3.49409529407102,0.00047567119700712,0.0205566342030107,late,sup,https://www.uniprot.org/uniprot/Q7X9S7,function:Transcription factor which may be involved in the signal transduction pathway downstream of the COP1 gene. Controls floral competency as a specific activator of FLC expression. Is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).|subunit:May form heterodimeric complex with the TALE/KNOX protein STM.|subcellular location:Nucleus|tissue specificity:Most abundant in flowers.|developmental stage:Down-regulated in the shoot apical meristem (SAM) upon floral induction.|induction:By light. In etiolated seedlings; maximally expressed after 3 days of illumination.|similarity:Belongs to the TALE/BELL homeobox family.
Cluster-38481.0,EDR2_ARATH,7.28290193740401,-2.54531589035275,0.864046745109521,-2.94580808823037,0.00322112184660079,0.082547000311865,late,sup,https://www.uniprot.org/uniprot/Q56W91,function:Negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens; including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis; and the downy mildew pathogen Hyaloperonospora parasitica; probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR). Prevents ethylene-induced senescence. Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P) in vitro.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell membrane|subcellular location:Single-pass membrane protein|subcellular location:Endosome membrane|subcellular location:Single-pass membrane protein|alternative products:F4JSE7-1|alternative products:1|alternative products:F4JSE7-2|alternative products:2|alternative products:F4JSE7-3|alternative products:3|tissue specificity:Expressed ubiquitously in all tissues and organs; including leaves; roots; flowers; stems and siliques.|domain:The pleckstrin homology domain (3-110) binds to phosphatidylinositol-4-phosphate (PtdIns(4)P).|disruption phenotype:Enhanced disease resistance salicylic acid-(SA-) dependent to the biotrophic powdery mildew pathogen Erysiphe cichoracearum at a late stage of the infection process and characterized by the formation of necrotic lesions. Enhanced ethylene-induced senescence phenotype. In edr2-6; exaggerated chlorosis and necrosis response to attack by pathogens (e.g. Hyaloperonospora parasitica; Golovinomyces cichoracearum and Blumeria graminis); but not in response to abiotic stresses or attack by the bacterial pathogen Pseudomonas syringae; characterized by initiation of cell death at infection site and hyper sensitive response (HR).
Cluster-38849.0,GATL4_ARATH,18.8614840012876,-1.75180450212343,0.535498474182753,-3.27135292924398,0.00107034243819884,0.0376936354761922,late,sup,https://www.uniprot.org/uniprot/Q8GX53,function:May be involved in pectin and/or xylans biosynthesis in cell walls.|pathway:Glycan metabolism; pectin biosynthesis.|subcellular location:Golgi apparatus membrane|subcellular location:Single-pass type II membrane protein|similarity:Belongs to the glycosyltransferase 8 family.|sequence caution:Truncated N-terminus.
Cluster-39218.0,UXS2_ARATH,22.5916352855695,-1.32062684825818,0.455427232649089,-2.89975379947413,0.00373455868056333,0.0901122029918438,late,sup,https://www.uniprot.org/uniprot/Q39077,function:Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.|catalytic activity:H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose|cofactor:NAD(+)|biophysicochemical properties:0.2 mM for UDP-D-glucuronate|biophysicochemical properties:Optimum pH is 7.0.|biophysicochemical properties:Optimum temperature is 50 degrees Celsius.|pathway:Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.|subunit:Homodimer.|subcellular location:Golgi apparatus|subcellular location:Golgi stack membrane|subcellular location:Single-pass type II membrane protein|tissue specificity:Ubiquitous.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Cluster-40177.0,PDCB3_ARATH,59.3144108595755,-1.77125298846013,0.555750854269472,-3.187134981175,0.00143689699654262,0.0460068029266371,late,sup,https://www.uniprot.org/uniprot/Q9FZ86,subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:GPI-anchor|subcellular location:Cell junction|subcellular location:Plasmodesma|tissue specificity:Expressed in the shoot apical region and in young leaves but also detected in the laminar and vasculature of mature leaves.|PTM:Contains two additional disulfide bonds.
Cluster-40329.0,DOF37_ARATH,27.5896982845071,-4.25165128085777,0.592962118151654,-7.17019038941435,7.48935383196819E-13,7.66571603510808E-10,late,sup,https://www.uniprot.org/uniprot/Q9SAF9,function:Transcription factor specifically involved in the maternal control of seed germination. Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence. May ensure the inactivity of a component that would be activated to trigger germination as a consequence of red light perception.|subcellular location:Nucleus|alternative products:Q43385-1|alternative products:1|alternative products:Q43385-2|alternative products:2|tissue specificity:Expressed in the phloem of the mother plant; including in roots; stem; leaves and flowers; but not present in the seed and embryo. In maturing siliques; found all through the funiculus connecting the placenta to the ovule; but not in the ovule.|developmental stage:Turned off in siliques when they reached full maturation. Not expressed in developing or mature embryos.|miscellaneous:The regulatory role of DOF3.7/DAG1 appears to be opposite to that of DOF2.5/DAG2. Both zinc finger proteins may act on a maternal switch that controls seed germination; possibly by regulating the same gene(s).
Cluster-40981.0,GALE2_CYATE,8.91671573960864,-3.96173300698885,1.02543254023614,-3.86347502301471,0.00011178532801625,0.00659284099991794,late,sup,https://www.uniprot.org/uniprot/O65781,catalytic activity:UDP-alpha-D-glucose = UDP-alpha-D-galactose|cofactor:NAD(+)|pathway:Carbohydrate metabolism; galactose metabolism.|similarity:Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Cluster-41582.0,IQM2_ARATH,11.7251997912275,-3.23464321129842,0.904729705284021,-3.57525920991284,0.00034988106904335,0.01639841406314,late,sup,https://www.uniprot.org/uniprot/Q9LHN9,function:May be involved in biotic and abiotic stress responses.|subcellular location:Cytoplasm|subcellular location:Nucleus|tissue specificity:Expressed in rosette and cauline leaves; stems; flowers and siliques; and at lower levels in roots.|induction:By light. Down-regulated by treatment with mannitol.|disruption phenotype:Long hypocotyl phenotype.
Cluster-42795.1,DCAM4_ARATH,42.997946449115,-2.25583620770177,0.525128566784841,-4.29577888232855,1.74081035460726E-05,0.0015918130418354,late,sup,https://www.uniprot.org/uniprot/Q3E9D5,function:Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis; and normal plant embryogenesis; growth and development.|catalytic activity:H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine|cofactor:Binds 1 pyruvoyl group covalently per subunit.|cofactor:pyruvate|pathway:Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.|induction:By auxin.|PTM:Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction; and the pyruvate is formed at the N-terminus of the alpha chain; which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway; termed non-hydrolytic serinolysis; in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain; while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (By similarity).|disruption phenotype:Reduction in the length of stem internodes. Increased thickness of veins in leaves and inflorescence stems. Altered morphology of xylem vessel elements. Altered homeostasis of polyamines. Hyposensitivity to auxin and hypersensitivity to cytokinin. The double mutants of bud2-1 and samdc1-1 are embryonic lethal.|similarity:Belongs to the eukaryotic AdoMetDC family.
Cluster-43721.0,PFPB_RICCO,20.4241646194642,-2.64615821398386,0.897185768114046,-2.94939833870336,0.00318393304538865,0.0820683960440146,late,sup,https://www.uniprot.org/uniprot/Q41141,function:Catalytic subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Catalyzes the phosphorylation of D-fructose 6-phosphate; the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs); which renders the reaction reversible; and can thus function both in glycolysis and gluconeogenesis.|catalytic activity:beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1;6-bisphosphate + H(+) + phosphate|cofactor:Mg(2+)|activity regulation:Allosterically activated by fructose 2;6-bisphosphate.|pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.|subunit:Tetramer of two alpha (regulatory) and two beta (catalytic) chains.|subcellular location:Cytoplasm|similarity:Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
Cluster-44175.0,IQD31_ARATH,99.4425779087362,-1.24263811206607,0.2895323177919,-4.29188051110485,1.77166283819838E-05,0.00159665013706516,late,sup,https://www.uniprot.org/uniprot/Q9SSF5,subunit:Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.|subcellular location:Associates to cortical microtubules (MTs).|subcellular location:Nucleus|subcellular location:Nucleus envelope|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Cell membrane|similarity:Belongs to the IQD family.
Cluster-44181.0,NA,5.67635753889709,-2.75469194559861,0.909718569904611,-3.02807047885969,0.00246120678790608,0.068563732555101,late,sup,NA,NA
Cluster-44845.0,PME28_ARATH,12.4275078210073,-3.69272726906273,1.07681312294348,-3.42931116865351,0.00060511533804544,0.0248066016488137,late,sup,https://www.uniprot.org/uniprot/Q3E8Z8,function:Acts in the modification of cell walls via demethylesterification of cell wall pectin.|catalytic activity:[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol|pathway:Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Expressed in flower buds.|miscellaneous:The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.|similarity:In the N-terminal section; belongs to the PMEI family.|similarity:In the C-terminal section; belongs to the pectinesterase family.
Cluster-45253.3,COPA1_ARATH,15.40537023639,-1.21935623990359,0.342964820415242,-3.55533911153705,0.00037749188795897,0.0172939652838508,late,sup,https://www.uniprot.org/uniprot/O80706,function:The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles; which further mediate biosynthetic protein transport from the ER; via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes; and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).|subunit:Oligomeric complex that consists of at least the alpha; beta; beta'; gamma; delta; epsilon and zeta subunits.|subcellular location:The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi; as well as on the vesicles/buds originating from it.|subcellular location:Cytoplasm|subcellular location:Golgi apparatus membrane|subcellular location:Peripheral membrane protein|subcellular location:Cytoplasmic side|subcellular location:Cytoplasmic vesicle|subcellular location:COPI-coated vesicle membrane|subcellular location:Peripheral membrane protein|subcellular location:Cytoplasmic side
Cluster-45293.0,Y1864_ARATH,77.0527649446386,-1.12005673218529,0.254162914117008,-4.40684564888823,1.04886874278501E-05,0.00105910416177302,late,sup,https://www.uniprot.org/uniprot/Q9M8N1,catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Cell membrane|subcellular location:Single-pass type I membrane protein|alternative products:Q0V7T5-1|alternative products:1|alternative products:Q0V7T5-2|alternative products:2|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-45715.0,KASC1_ARATH,15.2335615986874,-4.07796971510634,0.934724784555144,-4.36274910271812,1.28438211709449E-05,0.00123495286592145,late,sup,https://www.uniprot.org/uniprot/Q9FL32,function:Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).|catalytic activity:a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]|subunit:Homodimer.|subcellular location:Plastid|subcellular location:Chloroplast stroma|alternative products:P52410-1|alternative products:1|alternative products:P52410-2|alternative products:2|similarity:Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Cluster-47445.0,CSLD1_ARATH,178.208588561018,-1.10240265265454,0.362062337105533,-3.04478687694382,0.00232845246414687,0.0659070443241573,late,sup,https://www.uniprot.org/uniprot/Q680J9,function:Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.|subcellular location:Golgi apparatus membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like D subfamily.
Cluster-50416.0,FAO4A_ARATH,306.620510794797,-2.47427356188655,0.379080669205764,-6.52703702109253,6.70834705836913E-11,4.1292161298165E-08,late,sup,https://www.uniprot.org/uniprot/O65709,function:Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.|catalytic activity:a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2|subcellular location:Membrane|subcellular location:Single-pass membrane protein|similarity:Belongs to the GMC oxidoreductase family.
Cluster-50757.0,DOF17_ARATH,51.4668137057743,-1.59754232687791,0.401258492816131,-3.98132963034866,6.85308330917717E-05,0.00452075537214535,late,sup,https://www.uniprot.org/uniprot/O82155,function:Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.|subcellular location:Nucleus
Cluster-51894.0,PATL3_ARATH,84.0011517123423,-1.82561039405734,0.395248465310313,-4.61889306166954,3.8579260845651E-06,0.0004800470378951,late,sup,https://www.uniprot.org/uniprot/Q9C7T9,function:Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).|subcellular location:Mainly membrane-associated. Also cytoplasmic (By similarity).|subcellular location:Membrane|subcellular location:Peripheral membrane protein|subcellular location:Cytoplasm|miscellaneous:'Patella' means 'small plate' in Latin.|similarity:Belongs to the patellin family.
Cluster-52352.0,KN14F_ARATH,259.947812739962,-1.24538200206505,0.213777206433049,-5.82560705532974,5.69053666772463E-09,1.96261661377068E-06,late,sup,https://www.uniprot.org/uniprot/O22240,function:Required for keeping the ATP levels stable and balancing the aerobic respiration pathways during seed germination at low temperature.|subunit:Interacts (via C-terminus) with VDAC3.|subcellular location:Associated with VDAC3 in mitochondrion.|subcellular location:Cytoplasm|subcellular location:Cytoskeleton|subcellular location:Mitochondrion|tissue specificity:Expressed in roots; leaves; stems and flowers (at protein level).|induction:Down-regulated by salicylic acid (SA).|disruption phenotype:No visible phenotype under normal growth conditions.|similarity:Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Cluster-52563.0,KAO1_ARATH,72.2138353506403,-2.10934805825795,0.366175166683031,-5.76048910516055,8.38705440484276E-09,2.71552281903735E-06,late,sup,https://www.uniprot.org/uniprot/Q9C5Y3,function:Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12); a key step in gibberellins (GAs) biosynthesis. GAs; which are involved many processes; including stem elongation; play a central role in plant development.|catalytic activity:ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]|cofactor:heme|pathway:Plant hormone biosynthesis; gibberellin biosynthesis.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|tissue specificity:Widely expressed. Highly expressed in influorescence stem; influorescence; and silique tissue. Weakly expressed in cauline and rosette leaves. Expressed at a higher level in stem and influorescence than AtKAO2/CYP88A4.|similarity:Belongs to the cytochrome P450 family.
Cluster-53102.1,CVIF1_ARATH,33.3197825679043,-2.10049058143527,0.420315151739725,-4.99741818190742,5.81029778499149E-07,9.96544587663676E-05,late,sup,https://www.uniprot.org/uniprot/Q9C7Y8,function:Inhibits fructosidases from vacuoles (vacuolar invertase VI).|subcellular location:Vacuole|alternative products:F4HWQ8-1|alternative products:1|alternative products:F4HWQ8-2|alternative products:2|tissue specificity:Mostly expressed in roots; senescent leaves and flowers (in sepals); and; to a lower extent; in stems; specifically in the vascular tissues (e.g. in the phloem).|disruption phenotype:Increased vacuolar invertase activity leading to accumulation of hexose.|similarity:Belongs to the PMEI family.
Cluster-53689.0,EDR2_ARATH,6.10535438850236,-3.13847293459829,1.07100228349166,-2.93040732309766,0.00338517953104889,0.0850908359050077,late,sup,https://www.uniprot.org/uniprot/Q56W91,function:Negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens; including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis; and the downy mildew pathogen Hyaloperonospora parasitica; probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR). Prevents ethylene-induced senescence. Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P) in vitro.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Single-pass membrane protein|subcellular location:Cell membrane|subcellular location:Single-pass membrane protein|subcellular location:Endosome membrane|subcellular location:Single-pass membrane protein|alternative products:F4JSE7-1|alternative products:1|alternative products:F4JSE7-2|alternative products:2|alternative products:F4JSE7-3|alternative products:3|tissue specificity:Expressed ubiquitously in all tissues and organs; including leaves; roots; flowers; stems and siliques.|domain:The pleckstrin homology domain (3-110) binds to phosphatidylinositol-4-phosphate (PtdIns(4)P).|disruption phenotype:Enhanced disease resistance salicylic acid-(SA-) dependent to the biotrophic powdery mildew pathogen Erysiphe cichoracearum at a late stage of the infection process and characterized by the formation of necrotic lesions. Enhanced ethylene-induced senescence phenotype. In edr2-6; exaggerated chlorosis and necrosis response to attack by pathogens (e.g. Hyaloperonospora parasitica; Golovinomyces cichoracearum and Blumeria graminis); but not in response to abiotic stresses or attack by the bacterial pathogen Pseudomonas syringae; characterized by initiation of cell death at infection site and hyper sensitive response (HR).
Cluster-54138.0,AB29G_ARATH,31.1561198342486,-1.57234248586039,0.520933191249161,-3.01831887902943,0.00254181290174528,0.0699494565241784,late,sup,https://www.uniprot.org/uniprot/O04323,function:May be a general defense protein.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|alternative products:Q94A18-1|alternative products:1|alternative products:Q94A18-2|alternative products:2|tissue specificity:Expressed in roots and stems; and; to a lower extent; in seedling and inflorescence.|induction:Repressed by cold/dark treatment.|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-54298.0,HMDH2_GOSHI,47.7865866923592,-1.29436729963755,0.443876723229593,-2.91605130861535,0.00354492198951709,0.0874057015093452,late,sup,https://www.uniprot.org/uniprot/O64967,function:Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.|catalytic activity:(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH|pathway:Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.|subcellular location:Endoplasmic reticulum membrane|subcellular location:Multi-pass membrane protein|subcellular location:Mitochondrion membrane|subcellular location:Multi-pass membrane protein|subcellular location:Plastid membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the HMG-CoA reductase family.
Cluster-54543.0,WDR44_XENLA,21.3465052405267,-1.81812786502555,0.526393369820507,-3.45393382451892,0.00055247292418092,0.0230657445845537,late,sup,https://www.uniprot.org/uniprot/Q498F0,function:Downstream effector for rab11. May be involved in vesicle recycling (By similarity).|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Cytoplasm|subcellular location:Perinuclear region|subcellular location:Endosome membrane|subcellular location:Golgi apparatus|subcellular location:Trans-Golgi network
Cluster-54850.0,NUDT8_ARATH,86.2490250364035,-1.14301791710671,0.376981567601195,-3.03202600694763,0.00242918273739016,0.0679699896449644,late,sup,https://www.uniprot.org/uniprot/Q9LVT5,function:Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity). May be involved in plant immunity and act as a positive regulator of defense response through salicylic acid (SA) signaling (PubMed:25436909).|cofactor:Mg(2+)|cofactor:Mn(2+)|tissue specificity:Expressed in roots; stems and; at lower level; leaves.|induction:Circadian regulation with a peak after 8 hours of light. Induced by abscisic acid (ABA). Down-regulated by salicylic acid (SA).|disruption phenotype:Small and stunted plant phenotype when grown on 12/12 hour photoperiod light. No visible phenotype when grown under short or long day light (8/16 hours or 16/8 hours of light/dark).|similarity:Belongs to the Nudix hydrolase family.
Cluster-56228.0,4CLL7_ARATH,9.75123435191644,-5.5647114993015,1.11111198223792,-5.00823642284322,5.49310344581556E-07,9.52438100195234E-05,late,sup,https://www.uniprot.org/uniprot/Q9M0X9,function:Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.|catalytic activity:ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA|catalytic activity:(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA|catalytic activity:ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA|catalytic activity:(9Z;12Z)-octadecadienoate + ATP + CoA = (9Z;12Z)-octadecadienoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA|catalytic activity:ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA|catalytic activity:(9Z;12Z;15Z)-octadecatrienoate + ATP + CoA = (9Z;12Z;15Z)-octadecatrienoyl-CoA + AMP + diphosphate|catalytic activity:ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA|biophysicochemical properties:75 uM for hexanoic acid|biophysicochemical properties:6 uM for nonanoic acid|biophysicochemical properties:54 uM for tetradecanoic acid|biophysicochemical properties:93 uM for OPDA|biophysicochemical properties:187 uM for OPC-6:0|biophysicochemical properties:kcat is 1.26 sec(-1) with hexanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 1.38 sec(-1) with nonanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 2.31 sec(-1) with tetradecanoic acid as substrate (PubMed:18267944; PubMed:15677481). kcat is 0.3 sec(-1) with OPDA as substrate (PubMed:18267944; PubMed:15677481). kcat is 0.41 sec(-1) with OPC-6:0 as substrate (PubMed:18267944; PubMed:15677481).|subcellular location:Peroxisome|tissue specificity:Expressed at low level in leaves.|induction:By methyl jasmonate.|domain:Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition; and are sufficient to confer the substrate specificity.|disruption phenotype:No obvious phenotype in growth; root and flower development; fertility; reproduction and morphology.|similarity:Belongs to the ATP-dependent AMP-binding enzyme family.
Cluster-57681.0,HTH_ARATH,3199.07514092683,-1.62432526883345,0.365770407445592,-4.44083292625324,8.96113496855852E-06,0.00093531846234329,late,sup,https://www.uniprot.org/uniprot/Q9SXZ3,cofactor:FAD|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q9S746-1|alternative products:1|tissue specificity:Expressed in roots; leaves; stems; inflorescences and siliques. Found not only in epidermis but also in all sub-epidermal cell layers.|miscellaneous:Mutations in the gene for this protein reveals an unusual pattern of genetic transmission in which progeny plants inherit; at relatively high frequency; DNA sequences different from those carried by their parents. The instability observed is not random but seems to be confined to the restoration of sequence information in progeny plants that; although absent from the parent genome; was present in the genome of an earlier ancestor.|similarity:Belongs to the GMC oxidoreductase family.
Cluster-57697.0,DIRL1_ARATH,3009.71952171764,-2.54790605104433,0.399487317091407,-6.37793977940316,1.79486058307112E-10,9.65269937302484E-08,late,sup,https://www.uniprot.org/uniprot/Q8LEU7,function:Putative lipid transfer protein required for systemic acquired resistance (SAR) long distance signaling. May interact with a lipid-derived molecule to promote long distance signaling associated with SAR. Together with AZI1; required for glycerol-3-phosphate- (G3P) and azelaic acid- (AA) induced systemic acquired resistance (SAR). Component of plant systemic immunity involved in priming defenses in a AA-dependent manner; by modulating production and/or translocation of a mobile signal(s) during SAR. Is able to bind with high affinity monoacylated phospholipids; mainly lysophosphatidylcholines (PubMed:18552128).|cofactor:Binds 1 zinc ion per subunit.|cofactor:Zn(2+)|subunit:Self-interacts and binds to AZI1 (PubMed:23602565). Does not interact with PDLP1 (PubMed:27078071).|subcellular location:Secreted|subcellular location:Extracellular space|subcellular location:Apoplast|subcellular location:Endoplasmic reticulum|subcellular location:Cell junction|subcellular location:Plasmodesma|induction:Induced by glycerol-3-phosphate (G3P).|disruption phenotype:No visible phenotype under normal growth condition; but compromised pathogen-induced glycerol-3-phosphate-(G3P) and azelaic acid- (AA) dependent systemic acquired resistance (SAR).|similarity:Belongs to the A9/FIL1 family.
Cluster-2964.2,RAS_PLESU,345.203410743401,-2.35804000240706,0.576098650428413,-4.09311842798715,4.25610201361598E-05,0.00311884796517402,late,sup,https://www.uniprot.org/uniprot/A0PDV5,function:Involved in the biosynthesis of rosmarinic acid; a compound with antiviral; antimicrobial and anti-inflammatory activities. Can use 4-coumaroyl- and caffeoyl-CoA as hydroxycinnamoyl donors and 4-Hydroxyphenyllactate and 3.4-Dihydroxyphenyllactate; but not shikimate or quinate; as hydroxycinnamoyl acceptors. Can also putatively catalyze amide formation with D-amino acids as acceptors.|catalytic activity:(2R)-3-(3;4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA|biophysicochemical properties:4.7 uM for 4-coumaroyl-CoA (in the presence of 4-Hydroxyphenyllactate)|biophysicochemical properties:3.4 uM for caffeoyl-CoA (in the presence of 4-Hydroxyphenyllactate)|biophysicochemical properties:1.3 uM for 4-coumaroyl-CoA (in the presence of 3.4-Dihydroxyphenyllactate)|biophysicochemical properties:4 uM for caffeoyl-CoA (in the presence of 3.4-Dihydroxyphenyllactate)|biophysicochemical properties:39 uM for 4-Hydroxyphenyllactate (in the presence of 4-coumaroyl-CoA)|biophysicochemical properties:219 uM for 4-Hydroxyphenyllactate (in the presence of caffeoyl-CoA)|biophysicochemical properties:56 uM for 3.4-Dihydroxyphenyllactate (in the presence of 4-coumaroyl-CoA)|biophysicochemical properties:132 uM for 3.4-Dihydroxyphenyllactate (in the presence of caffeoyl-CoA)|biophysicochemical properties:Optimum pH is 7.8.|similarity:Belongs to the plant acyltransferase family.
Cluster-24286.0,GAT22_ARATH,6.78493004741134,-3.45946303953922,1.21077319179056,-2.85723458612688,0.00427349869784554,0.0987604615314195,late,sup,https://www.uniprot.org/uniprot/A3E4C1,function:Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (PubMed:22102866; PubMed:25077795). Involved in the modulation of chloroplast development; growth and division in a cytokinin-dependent manner (PubMed:22102866; PubMed:22811435). Repressor of the gibberellic acid (GA) signaling pathway that regulates flowering and modulates greening; in a SOC1-dependent manner (PubMed:20844019; PubMed:23739688; PubMed:25077795). Prevents the accumulation of SOC1 during flowering (PubMed:23739688). Promotes chlorophyll biosynthesis throughout the plant; by regulating chlorophyll biosynthetic genes (e.g. HEMA1 and GUN4) and chloroplast localized glutamate synthase (e.g. GLU1) (PubMed:18417639; PubMed:20844019; PubMed:21453984; PubMed:22102866; PubMed:23878229; PubMed:25077795). Involved in the regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639). Regulator of germination; senescence; elongation growth and flowering time (PubMed:20844019; PubMed:22102866; PubMed:23878229). Influences also leaf starch content (PubMed:22102866).|subunit:Forms heterodimers with GATA18.|subcellular location:Nucleus|tissue specificity:Expressed predominantly in leaves; and barely in stems; flowers and siliques.|developmental stage:First observed in the inflorescence meristem (IM) and young flower buds (PubMed:23335616). Detected throughout the floral bud. In young flowers; restricted to the inner whorls; specifically the petals; stamens; and carpels (PubMed:18417639; PubMed:23335616). In older flowers; accumulates more in the stamens than in the petals and carpels (PubMed:18417639). Observed in anther locules; vascular strands; and ovules (PubMed:23335616). During imbibition; expressed in the endosperm; especially at the time of testa rupture. Later restricted to the cotyledons (PubMed:20844019). In mature embryos; restricted to the cotyledons. In young seedlings; mostly expressed in shoot tissues; including the tip; circumference; and vasculature of the cotyledons; the emerging leaves; the meristematic region; and the basal part of the hypocotyl; and; at low levels; in the primary roots. In older seedlings; accumulates in the green shoot tissues (PubMed:22811435).|induction:By light (including both red and white lights) (PubMed:17208962; PubMed:17587690). Levels follow a circadian and diurnal rhythm; with a peak at 20 hours; thus preempting dawn (PubMed:17208962). Activated by gibberellic acid (GA) (PubMed:20844019). Induced by cytokinin and derivatives (e.g. benzyladenine; t-Zeatin and 6-benzylaminopurine) in light conditions (PubMed:16212609; PubMed:17587690; PubMed:21453984; PubMed:22811435). Triggered by nitrate (PubMed:16262716). Negatively regulated by AP3/PI (PubMed:18417639). Strong accumulation during cold imbibition of nondormant seeds; but not at warm temperatures. Regulated by PIF transcription factors (PubMed:20844019). Repressed by HAN (PubMed:23335616). Inhibited by SOC1 (PubMed:23739688). Down-regulated by auxin (2;4D) and auxin response factors (e.g. ARF2 and ARF7) (PubMed:23878229).|disruption phenotype:Pale green leaves and reduced chlorophyll levels associated with altered regulation of sugar-sensing genes (e.g. HXK1; HXK2; STP13 and PLT6) (PubMed:18417639; PubMed:21453984; PubMed:22102866; PubMed:22811435). Reduced chloroplast size (PubMed:22811435). Faster seed germination. Early flowering. Increased leaves size (PubMed:20844019; PubMed:22102866). Reduced gibberellic acid (GA) levels due to increased GA turnover and associated with reduced expression of GA-anabolizing enzymes (e.g. GA3OX1) but increased expression of GA-catabolizing enzymes (e.g. GA2OX2) (PubMed:20844019). Small seeds with deformed seed coats (PubMed:22102866). The double mutant gnc cga1; lacking both GATA22 and GATA21; exhibits reduced sensitivity to cytokinin (e.g. benzyladenine) toward chloroplasts growth (PubMed:22811435).|similarity:Belongs to the type IV zinc-finger family. Class B subfamily.
Cluster-24940.0,MPK15_ARATH,5.30177295466418,-4.00386206663711,1.08427575376399,-3.69266033362636,0.00022192034030329,0.0116581662215619,late,sup,https://www.uniprot.org/uniprot/Q94EY5,catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|activity regulation:Activated by threonine and tyrosine phosphorylation.|subunit:Interacts with MKK7.|alternative products:Q9C9U4-1|alternative products:1|alternative products:Q9C9U4-2|alternative products:2|domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.|PTM:Dually phosphorylated on Thr-252 and Tyr-254; which activates the enzyme.|miscellaneous:Isoform 1|miscellaneous:Inferred from the gene model conservation between members of the family.|similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Cluster-25253.0,RAA5A_ARATH,79.9803464782529,-1.11235381404056,0.175244179857611,-6.34745082515361,2.18911918699981E-10,1.09867238496804E-07,late,sup,https://www.uniprot.org/uniprot/Q9FGK5,function:Intracellular vesicle trafficking and protein transport.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Cytoplasmic side|similarity:Belongs to the small GTPase superfamily. Rab family.
Cluster-28965.1,LFG5_ARATH,10.8136490122041,-1.49637903399304,0.478921322652568,-3.12447778625756,0.00178120970443166,0.0536221858838868,late,sup,https://www.uniprot.org/uniprot/Q940C4,subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the BI1 family.|caution:Was originally thought to contain a F-box domain and LRR repeats; but it lacks both types of domains.|sequence caution:The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.|sequence caution:The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.
Cluster-29882.0,AP180_ARATH,12.0171890956459,-2.43411863410343,0.727000437840988,-3.34816666869164,0.00081348073297167,0.0306189129978543,late,sup,https://www.uniprot.org/uniprot/Q9ZVN6,function:Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins; leading to their selection and concentration. Binding of AP180 to clathrin triskelia promotes their assembly into 70-90 nm coats cages.|subunit:Interacts with ALPHAC-AD and clathrin.|subcellular location:Colocalized with clathrin in the Golgi area.|subcellular location:Membrane|subcellular location:Clathrin-coated pit|subcellular location:Golgi apparatus|subcellular location:Cytoplasmic vesicle|subcellular location:Clathrin-coated vesicle
Cluster-30616.0,C71DA_SOYBN,4.85561091066131,-3.91344848445357,1.29792826890375,-3.01515004967026,0.00256852151571002,0.0705600570211445,late,sup,https://www.uniprot.org/uniprot/O48923,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-32677.1,PLY15_ARATH,135.261175025612,-1.38901412460416,0.323700440666478,-4.29104798789979,1.77831876515473E-05,0.00159665013706516,late,sup,https://www.uniprot.org/uniprot/Q9SVP1,catalytic activity:Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.|cofactor:Binds 1 Ca(2+) ion. Required for its activity.|cofactor:Ca(2+)|pathway:Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.|alternative products:A number of isoforms are produced. According to EST sequences.|alternative products:Q944R1-1|alternative products:1|tissue specificity:Expressed in flowers; but not in leaves.|similarity:Belongs to the polysaccharide lyase 1 family.
Cluster-33474.0,HAK5_ORYSJ,28.1742741148385,-3.051243104745,1.01825382226038,-2.99654471020954,0.00273058192876722,0.0739892097350846,late,sup,https://www.uniprot.org/uniprot/Q0JGC6,function:High-affinity potassium transporter.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
Cluster-33994.0,AB42G_ORYSJ,25.2637254264919,-2.82581097236378,0.765367608492353,-3.69209637435553,0.0002224131470848,0.0116647424082656,late,sup,https://www.uniprot.org/uniprot/Q8GU93,function:May be a general defense protein.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|alternative products:Q5Z9S8-1|alternative products:1|alternative products:Q5Z9S8-2|alternative products:2|similarity:Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Cluster-35752.0,AAE_RAUSE,5.42461269111232,-4.25748516461586,1.42052584266882,-2.99711912077368,0.0027254419322525,0.0739130534276683,late,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-35752.2,AAE_RAUSE,6.60384718040827,-4.98084978221254,1.41266324317738,-3.52585784776955,0.00042211347577136,0.0188377786022863,late,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-35845.0,EIF3C_MEDTR,88.6558426497154,-3.7082121463298,0.79846381358513,-4.64418309663878,3.41424674508723E-06,0.00043160975785505,late,sup,https://www.uniprot.org/uniprot/Q9XHM1,function:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is involved in protein synthesis of a specialized repertoire of mRNAs and; together with other initiation factors; stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|subunit:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|subcellular location:Cytoplasm|similarity:Belongs to the eIF-3 subunit C family.
Cluster-37427.0,NA,35.963596866525,-2.25819129022756,0.505666307412246,-4.46577368736289,7.97799104572924E-06,0.00084430726046572,late,sup,NA,NA
Cluster-37832.0,GRXC9_ARATH,232.625199166408,-1.19776166250949,0.316663328286383,-3.78244512552543,0.00015529533567128,0.00864477368570129,late,sup,https://www.uniprot.org/uniprot/C1JGQ9,function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).|subunit:Interacts with TGA2 and TGA6.|subcellular location:Cytoplasm|subcellular location:Nucleus|induction:Up-regulated by salicylic acid (SA).|similarity:Belongs to the glutaredoxin family. CC-type subfamily.
Cluster-37947.0,PRK1_ARATH,6.73367409281105,-3.06542365420598,0.980760521451551,-3.12555775559672,0.00177468217213678,0.0535705391193992,late,sup,https://www.uniprot.org/uniprot/O65240,function:Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth (PubMed:23024212).|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subunit:Interacts in vitro with ROPGEF1 (via PRONE domain).|subcellular location:Preferentially localized to the apical region of the pollen tube plasma membrane.|subcellular location:Cell membrane|subcellular location:Single-pass type I membrane protein|tissue specificity:Expressed in pollen and/or in flowers; but not in leaves.|domain:The protein kinase domain may be catalytically impaired due to the lack of the conserved Asp active site at position 485; which is replaced by a His residue.|disruption phenotype:No effect on pollen germination and growth. Prk1 and prk2 double mutant has no effect on pollen germination and growth. Prk1; prk2 and prk5 triple mutant shows reduced pollen tube elongation.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-39352.0,C71DA_SOYBN,14.2030592720077,-4.03160686579797,0.778654428218148,-5.17765868875079,2.24687805269727E-07,4.59957681368286E-05,late,sup,https://www.uniprot.org/uniprot/O48923,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-39382.0,EXPB2_ARATH,21.5892227767786,-6.65471892976405,0.948568285931506,-7.01554018668148,2.29062214537934E-12,2.0766125906539E-09,late,sup,https://www.uniprot.org/uniprot/O04484,function:May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Membrane|subcellular location:Peripheral membrane protein|similarity:Belongs to the expansin family. Expansin B subfamily.
Cluster-39837.0,VINSY_RAUSE,6.64717694109104,-3.11675136374735,0.718976760554296,-4.33498206721521,1.45772005346909E-05,0.00136440876981044,late,sup,https://www.uniprot.org/uniprot/Q70PR7,function:Acetyltransferase that catalyzes the formation of vinorine; a precursor of the antiarrhythmic monoterpenoid indole alkaloid ajmaline. Acts on gardneral; but not on polyneuridine aldehyde or N-methylgardneral.|catalytic activity:16-epivellosimine + acetyl-CoA = CoA + vinorine|activity regulation:Complete inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF); N-tosyl-L-phenylalanine chloromethylketone (TPCK); Hg(2+) and diethyl-pyrocarbonate (DEPC) (PubMed:15110860). 50% inhibition by N-(N-(L-3-trans-carboxirane-2-carbonyl)-L-leucyl)-agmanitine (E-64); N-alpha-p-tosyl-L-lysine chloromethylketone (TLCK) and phenylmethylsulfonyl fluoride (PMSF) (PubMed:15110860).|biophysicochemical properties:57 uM for Acetyl-CoA|biophysicochemical properties:7.5 uM for gardneral|biophysicochemical properties:63 uM for CoA|biophysicochemical properties:10 uM for vinorine|biophysicochemical properties:3.9 umol/min/mg enzyme for the forward reaction|biophysicochemical properties:44.1 umol/min/mg enzyme for the reverse reaction|biophysicochemical properties:Except vinorine; no other acetylated alkaloids are deacetylated by the reverse reaction.|biophysicochemical properties:Optimum pH is 7.8.|biophysicochemical properties:Optimum temperature is 35 degrees Celsius.|subunit:Monomer.|similarity:Belongs to the plant acyltransferase family.
Cluster-41687.1,PINI_ARATH,147.504747473683,-1.30264397907166,0.333588661968145,-3.90494080759871,9.4248451112044E-05,0.00585225705241713,late,sup,https://www.uniprot.org/uniprot/Q9ZSY6,function:Acts as a component of the auxin efflux carrier. Seems to be involved in the basipetal auxin transport. Mediates the formation of auxin gradient which is required to ensure correct organogenesis. Coordinated polar localization of PIN1 is directly regulated by the vesicle trafficking process and apical-basal PIN1 polarity also depends on the phosphorylation of conserved serine residues by PID kinase. The ARF-GEF protein GNOM is required for the correct recycling of PIN1 between the plasma membrane and endosomal compartments.|subunit:Interacts with TOPP4 (PubMed:11574889). Interacts with FYPP1 AND FYPP3 (PubMed:22715043).|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Expressed at the basal side of elongated parenchymatous xylem cells.|developmental stage:Expressed during embryogenesis. Already detected in the 8-cell stage at the inner cell boundaries. Later; polarity is gradually established at the basal side of provascular cells then in epidermis cells.|induction:Down-regulated by endoplasmic reticulum stress treatment.|disruption phenotype:Plants exhibit developed naked; pin-shaped inflorescences and abnormalities in the number; size; shape; and position of lateral organs.|similarity:Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
Cluster-42925.0,NA,26.096248399232,-3.35945727834207,1.08803352158581,-3.08764133796691,0.00201751806437897,0.0590007817352486,late,sup,NA,NA
Cluster-43032.0,PRK1_PETIN,6.04806456183714,-2.29479853501793,0.780004526745115,-2.94203232972751,0.00326065883593066,0.0831601769336876,late,sup,https://www.uniprot.org/uniprot/Q40902,function:Dual-specificity kinase with both serine/threonine and tyrosine kinase activities (PubMed:8038606). Required for postmeiotic development of microspores (Ref.2). Involved in embryo sac development at the late stages of megagametogenesis (Ref.3). Involved in the phosphorylation of KIP1 (PubMed:11500547).|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|catalytic activity:ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]|subunit:Interacts with KIP1.|subcellular location:Microsome membrane|subcellular location:Single-pass membrane protein|subcellular location:Cytoplasm|tissue specificity:Expressed in mature pollen grains and pollen tubes; but not in style; petal; leaf; root or sepal (PubMed:8038606; PubMed:11500547). Very low expression in the ovary (Ref.3).|developmental stage:Detected around the time of microspore mitosis with a peak in mature pollen grains.|PTM:Autophosphorylated.|similarity:Belongs to the protein kinase superfamily.
Cluster-46590.0,DRM1_ARATH,19.3010579076966,-3.49890439115175,1.01256393590622,-3.45548983829878,0.00054929389649111,0.0229935294665738,late,sup,https://www.uniprot.org/uniprot/O65923,alternative products:B9DGG8-1|alternative products:1|alternative products:B9DGG8-2|alternative products:2|alternative products:B9DGG8-3|alternative products:3|alternative products:B9DGG8-4|alternative products:4|alternative products:B9DGG8-5|alternative products:5|tissue specificity:Isoform 1: Expressed mainly in the low bolt. Isoform 2: Expressed mainly in the low bolt. Detected in flowers. Isoform 4: Expressed mainly in the low bolt. Isoform 5: Expressed mainly in the 6 days old seedlings. Detected in 16 days old seedlings; axil; low bolt and floral samples; but only barely in leaves and top bolt.|induction:Circadian-regulation (PubMed:24442277). Down-regulated in axillary buds within 24 hours after decapitation and then up-regulated (PubMed:15908603). Down-regulated by the transcription factor ERF114 (PubMed:23616605). Down-regulated by cold (PubMed:24442277). Almost complete down-regulation by sucrose; fructose and glucose; but not by other sugars (PubMed:16463203). Up-regulated by heat and dark growth conditions (PubMed:24442277). Isoform 2: Up-regulated by salt. Isoform 4: Up-regulated by salt. Isoform 1: Not up-regulated by salt. Isoform 5: Not up-regulated by salt (PubMed:24442277).|disruption phenotype:No visible phenotype. Drm1 and drmh1 double mutants have no visible phenotype.|miscellaneous:Predicted to be an intrinsically disordered protein.|miscellaneous:Isoform 3|miscellaneous:May be artifactual or particularly rare.|similarity:Belongs to the DRM1/ARP family.
Cluster-48688.0,MDIS2_ARATH,5.09831070294812,-4.99011410430041,1.1819765264991,-4.22183858344518,2.42317620105891E-05,0.00202894186415064,late,sup,https://www.uniprot.org/uniprot/Q9SN49,function:Involved in the pollen tube perception of the female signal by binding an unidentified female attractant (PubMed:26863186). May be involved in the regulation of root hairs development (PubMed:16367956).|catalytic activity:ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]|catalytic activity:ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]|subcellular location:Endomembrane system|subcellular location:Single-pass type I membrane protein|tissue specificity:Expressed in pollen tubes and seedlings.|disruption phenotype:Short straight root hairs.|similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Cluster-50321.0,NA,13.8475524434722,-1.75713357986915,0.606915089466369,-2.89518848742765,0.00378930924637047,0.0910869563540418,late,sup,NA,NA
Cluster-54587.1,PRP4_ARATH,875.662576250539,-1.40329570453505,0.455315059068061,-3.08203226883668,0.00205592548989599,0.0596839119802378,late,sup,https://www.uniprot.org/uniprot/Q9M7N8,subcellular location:Secreted|subcellular location:Cell wall|tissue specificity:Mostly expressed in aerial organs; particularly in expanding leaves; stems; flowers; and siliques. Also present in stipules.|developmental stage:In young seedlings; detected in the hypocotyl; cotyledons and rosette leaves;mostly in expanding leaves. At flowering time; expressed in stems; cauline leaves; sepals; and; in open flowers only; in anthers and on stigma surface. Later present in pedicels of developing siliques; nectaries; and along the length of maturing siliques. Expressed in roots during the early stages of lateral root formation.|similarity:Belongs to the plant proline-rich protein superfamily.
Cluster-56748.0,LOR15_ARATH,41.6816250112987,-1.4498843351181,0.374392253717238,-3.87263443813968,0.00010766525305672,0.00641176890973365,late,sup,https://www.uniprot.org/uniprot/Q8LEK9,function:Might be related to the phospholipid scramblase and tubby-like superfamily of membrane tethered transcription factors.|alternative products:Q9LZX1-1|alternative products:1|alternative products:Q9LZX1-2|alternative products:2|similarity:Belongs to the LOR family.
Cluster-57485.0,GASA6_ARATH,609.530204337212,-1.20432997119906,0.34089205895209,-3.53287775286172,0.00041106250128413,0.0185007278946746,late,sup,https://www.uniprot.org/uniprot/Q9CA50,function:Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination; flowering and seed maturation.|subcellular location:Secreted|PTM:Six disulfide bonds may be present.|similarity:Belongs to the GASA family.
Cluster-618.3,NA,797.751074518542,-3.60630211004382,1.11791948463997,-3.22590504915053,0.00125575009179907,0.04218852260136,late,sup,NA,NA
Cluster-618.4,NA,2355.90210104848,-1.67067328037467,0.523618331875867,-3.19063176109489,0.0014196209224734,0.0455916719332802,late,sup,NA,NA
Cluster-16818.1,NA,6.92873137430523,-2.94510899717712,0.942363790430437,-3.12523573919569,0.00177662619360647,0.0535705391193992,late,sup,NA,NA
Cluster-23290.0,PMA8_ARATH,42.8694632671364,-3.6370037025947,0.750443560082491,-4.84647200143194,1.25676314824343E-06,0.00018634156398955,late,sup,https://www.uniprot.org/uniprot/Q9M2A0,function:The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).|catalytic activity:ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate|subunit:Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-947. Binding to 14-3-3 proteins activates the H(+)-ATPase (By similarity).|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
Cluster-24398.0,NA,15.5559401965883,-2.9215093323501,0.927482679928326,-3.14993411259806,0.00163307287672453,0.0504060334420907,late,sup,NA,NA
Cluster-24752.0,NA,6.91056987734243,-4.32909973255377,1.17692142118481,-3.67832520899793,0.00023477049655549,0.0121127389954512,late,sup,NA,NA
Cluster-25495.2,NA,6.28794661587542,-4.19515717019439,0.971810124032144,-4.31684859670759,1.58272639759941E-05,0.0014642549524661,late,sup,NA,NA
Cluster-27760.0,NA,50.6183373452093,-1.96629413645966,0.68845840902599,-2.85608267787957,0.0042890343102806,0.0989033856578512,late,sup,NA,NA
Cluster-27925.0,NA,38.3396869688914,-1.4054433944775,0.284122361458143,-4.946613097486,7.55158601842377E-07,0.00012415120433398,late,sup,NA,NA
Cluster-28226.1,NA,22.9500722985968,-3.60901006424841,1.17262641521635,-3.07771513366647,0.00208594211911503,0.0603895469338685,late,sup,NA,NA
Cluster-28352.0,NA,4.31333955810102,-4.7150631601562,1.10895893956899,-4.25179237203208,2.12066424189191E-05,0.0018362342861132,late,sup,NA,NA
Cluster-28388.0,NA,122.227021546578,-1.88691113972038,0.648895265869035,-2.907882425669,0.00363885119620884,0.0889528108287415,late,sup,NA,NA
Cluster-28776.0,NA,6.60370593445959,-4.0556157442758,1.24573882965872,-3.25559069663652,0.00113156748839952,0.0389844043506153,late,sup,NA,NA
Cluster-29607.0,NA,3.74404876776329,-3.90599038054712,1.29340803336195,-3.01992123119439,0.00252840432585975,0.0696408587322308,late,sup,NA,NA
Cluster-29634.0,LEA1_CICAR,11.094696238263,-4.31011719105117,1.2182082031955,-3.53807927064129,0.00040304903669747,0.0182175868011549,late,sup,https://www.uniprot.org/uniprot/O49816,tissue specificity:Highest expression is found in seeds. No expression detected in adult tissues.|developmental stage:Not expressed in the first stages of embryogenesis. Levels increase during late embryogenesis and decrease in germinating seedlings.|induction:Up-regulated in response to water stress.|similarity:Belongs to the LEA type 4 family.
Cluster-29636.0,BDG3_ARATH,4.0724948283371,-4.07066096565796,0.973946826938585,-4.17955154538909,2.92084512173678E-05,0.00233446890964,late,sup,https://www.uniprot.org/uniprot/O22977,function:Involved in cuticle development and morphogenesis.|subcellular location:Cell membrane|subcellular location:Lipid-anchor|subcellular location:Secreted|subcellular location:Cell wall
Cluster-29817.0,NA,6.08635750486931,-5.19149270720048,1.41769176706277,-3.66193331146757,0.0002503190295687,0.0126273812531241,late,sup,NA,NA
Cluster-29989.0,EF2_ARATH,4.96109511864643,-3.54662284606755,0.809527166967252,-4.38110416893646,1.18079398759944E-05,0.00115396712461269,late,sup,https://www.uniprot.org/uniprot/Q9SGT4,function:Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step; the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites; respectively. Catalyzes the coordinated movement of the two tRNA molecules; the mRNA and conformational changes in the ribosome (By similarity). Involved in cold responses leading to freezing tolerance via the induction of cold-responsive genes (PubMed:9401119; PubMed:12032361).|pathway:Protein biosynthesis; polypeptide chain elongation.|subunit:May interact with glutaredoxins (Grxs).|subcellular location:Cytoplasm|alternative products:Q9ASR1-1|alternative products:1|alternative products:Q9ASR1-2|alternative products:2|tissue specificity:Expressed in root; stem; leaves; flowers and siliques.|induction:Induced by cold.|disruption phenotype:Blocks specifically low temperature-induced transcription of cold-responsive genes such as RD29A (PubMed:9401119; PubMed:12032361). Reduced capacity to develop freezing tolerance but does not impair the vernalization response. Defective in protein synthesis in the cold (PubMed:12032361).|similarity:Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.|sequence caution:Truncated N-terminus.|sequence caution:Truncated N-terminus.
Cluster-30434.0,PIN2_ARATH,21.6147532235487,-2.40290407720704,0.653260772554253,-3.678322927323,0.00023477259635053,0.0121127389954512,late,sup,https://www.uniprot.org/uniprot/Q9SYT2,function:Acts as a component of the auxin efflux carrier. Seems to be involved in the root-specific auxin transport; and mediates the root gravitropism. Its particular localization suggest a role in the translocation of auxin towards the elongation zone.|subunit:Interacts with FYPP1 AND FYPP3.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Root-specific. Localized to the cortex; epidermis and lateral root cap; predominantly at the upper side of cells.|induction:Down-regulated by endoplasmic reticulum stress treatment.|disruption phenotype:Loss-of-function mutations impair the root gravitropic response; lead to an increased sensitivity to ethylene and auxin transport inhibitors; and give rise to an auxin accumulation in root tips.|similarity:Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
Cluster-30951.0,NA,42.2564652184056,-1.12325952619996,0.328201130024131,-3.42247306131266,0.00062054246486856,0.025308242172596,late,sup,NA,NA
Cluster-31349.0,MSL7_ARATH,42.1917397567782,-1.85242455370975,0.407640442200931,-4.54426097594279,5.51283229451003E-06,0.00063840207556497,late,sup,https://www.uniprot.org/uniprot/F4IME1,function:Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.|subcellular location:Membrane|subcellular location:Multi-pass membrane protein|developmental stage:Expressed during somatic embryogenesis.|similarity:Belongs to the MscS (TC 1.A.23) family.
Cluster-31680.0,NA,13.1213576170521,-4.06051863241074,1.20442080094539,-3.3713454875767,0.00074801985750242,0.028909464163888,late,sup,NA,NA
Cluster-32109.0,NA,166.624683589775,-1.61386912141267,0.426156141021585,-3.78703711166495,0.00015245433708236,0.00853152754078219,late,sup,NA,NA
Cluster-32193.0,NA,36.1527849438581,-3.5245597753391,0.87166598381712,-4.04347518519039,5.26647324375874E-05,0.00365736364824056,late,sup,NA,NA
Cluster-33077.0,C7A52_PANGI,4.25707187510837,-5.02517050931918,1.5913555038626,-3.15779252160934,0.00158968655577304,0.0495488746706077,late,sup,https://www.uniprot.org/uniprot/I7C6E8,function:Component of the oleanane-type triterpene saponins (e.g. ginsenosides or panaxosides) biosynthetic pathway (PubMed:29378087). Catalyzes the carboxylation of beta-amyrin at the C-28 position to form oleanolic acid during ginsenoside biosynthesis; a class of tetracyclic triterpenoid saponins.|catalytic activity:beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]|cofactor:heme|pathway:Secondary metabolite biosynthesis; terpenoid biosynthesis.|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Mostly expressed in roots; and; to a lower extent; in stems and leaves (PubMed:30577538). Accumulates only in the rhizome of plants (PubMed:22875608).|developmental stage:Progressive increase in roots from the leaf opened stage to the green fruit; red fruit and root growth stages; respectively.|induction:Expression is not affected by methyl jasmonate (MeJA) treatment (PubMed:22875608). Influenced in roots and leaves by relative humidity and soil water potential (PubMed:30577538).|similarity:Belongs to the cytochrome P450 family.
Cluster-33649.0,C76A2_SOLME,4.43724036292923,-4.54882534195934,1.30837524316428,-3.47669780953519,0.00050762961367413,0.0216202518682958,late,sup,https://www.uniprot.org/uniprot/P37122,cofactor:heme|similarity:Belongs to the cytochrome P450 family.
Cluster-34251.0,NA,22.9387648992533,-1.51843248789213,0.472257605002368,-3.21526317799481,0.00130324979501806,0.0432101525558234,late,sup,NA,NA
Cluster-34958.0,NA,20.5516031064065,-6.66065298892231,1.7332546025061,-3.84285896560823,0.00012160935818018,0.00700302166072106,late,sup,NA,NA
Cluster-36639.1,WRKY7_ARATH,58.4614142078821,-1.19671042483775,0.37503433352788,-3.19093565002573,0.00141812861937467,0.0455898896583165,late,sup,https://www.uniprot.org/uniprot/Q9STX0,function:Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'); a frequently occurring elicitor-responsive cis-acting element (By similarity).|subcellular location:Nucleus|tissue specificity:In young; mature and senescent leaves.|induction:By salicylic acid and strongly during leaf senescence.|similarity:Belongs to the WRKY group II-d family.
Cluster-38783.0,POLC2_TOBAC,7.88632220529295,-2.30869880698188,0.808207163935594,-2.85656810531052,0.00428248119108058,0.0988960176077052,late,sup,https://www.uniprot.org/uniprot/Q8VWY7,allergen:Causes an allergic reaction in human.
Cluster-41094.2,ADS3_ARATH,33.3364965222263,-7.69228912368,2.1197920312774,-3.62879424499233,0.00028474807127539,0.0139215043167463,late,sup,https://www.uniprot.org/uniprot/Q9LVZ4,function:Fatty acid desaturase involved in the first desaturation step leading to the formation of hexadeca 7;10;13-trienoic acid (16:3(7Z;10Z;13Z)); the major functional components of thylakoid membranes (PubMed:15579662; PubMed:16666902; PubMed:15240892). Required for chloroplast biogenesis at low temperature (PubMed:16668849). Also indirectly involved in the production of the oxylipin dinor-oxo-phyto-dienoic acid implicated in wound signaling (PubMed:15579662).|catalytic activity:a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]|cofactor:Fe(2+)|pathway:Lipid metabolism; oxylipin biosynthesis.|pathway:Lipid metabolism; polyunsaturated fatty acid biosynthesis.|subcellular location:Plastid|subcellular location:Chloroplast membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Highly expressed in young leaves. Low expression in roots.|domain:The histidine box domains are involved in binding the catalytic metal ions.|miscellaneous:Substrate specificity shifts from delta-7 to delta-9 desaturation when the protein is retargeted to the cytoplasm.|similarity:Belongs to the fatty acid desaturase type 1 family.
Cluster-41197.0,NA,5.04010576473382,-3.48191785468968,1.17095688611433,-2.97356623115644,0.00294360872338305,0.0779124273145502,late,sup,NA,NA
Cluster-41668.1,NA,8.53792870052866,-2.1700170888273,0.67963085637378,-3.19293491235166,0.00140834687027646,0.0454596604210295,late,sup,NA,NA
Cluster-42564.8,NA,12.4672132035017,-3.11259920563594,0.703517858824228,-4.42433573873725,9.67394762917016E-06,0.00099985132988133,late,sup,NA,NA
Cluster-42920.0,LEA1_CICAR,15.1028699912358,-3.54472485897398,1.22553384771652,-2.89239245866501,0.00382320042587056,0.091554829821036,late,sup,https://www.uniprot.org/uniprot/O49816,tissue specificity:Highest expression is found in seeds. No expression detected in adult tissues.|developmental stage:Not expressed in the first stages of embryogenesis. Levels increase during late embryogenesis and decrease in germinating seedlings.|induction:Up-regulated in response to water stress.|similarity:Belongs to the LEA type 4 family.
Cluster-42946.0,NA,5.14177301313226,-3.92690171667547,1.15201153454589,-3.40873472089273,0.0006526491199292,0.0260813055105208,late,sup,NA,NA
Cluster-44509.1,C7A15_VITVI,4.33439992033528,-4.89342244650864,1.53453886791182,-3.18885532900679,0.00142837342881941,0.0458263790661676,late,sup,https://www.uniprot.org/uniprot/F1T282,function:Catalyzes the carboxylation of beta-amyrin at the C-28 position to form oleanolic acid. Catalyzes the carboxylation of alpha-amyrin and lupeol at the C-28 position to form ursolic acid and betulinic acid respectively. May be involved in saponin biosynthesis in fruit skin.|catalytic activity:beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]|cofactor:heme|subcellular location:Membrane|subcellular location:Single-pass membrane protein|tissue specificity:Expressed in leaves; stems and fruit skin.|similarity:Belongs to the cytochrome P450 family.
Cluster-44687.0,CSPLC_POPTR,12.7614578640526,-2.74565449260064,0.674961514917056,-4.06786821458709,4.74451999620276E-05,0.003398275834752,late,sup,https://www.uniprot.org/uniprot/B9HTL5,subunit:Homodimer and heterodimers.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|similarity:Belongs to the Casparian strip membrane proteins (CASP) family.
Cluster-44984.0,RH20_ORYSJ,12.0500324253577,-4.29433106891366,1.31341370089058,-3.26959515193258,0.00107701507476568,0.0377744048844891,late,sup,https://www.uniprot.org/uniprot/A0A0P0UZY0,function:ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.|catalytic activity:ATP + H2O = ADP + H(+) + phosphate|subcellular location:Nucleus|domain:The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|similarity:Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Cluster-45080.0,AAE_RAUSE,25.6324666166783,-3.44118452589747,1.08187939163212,-3.18074690442722,0.00146895903551705,0.0465170361247067,late,sup,https://www.uniprot.org/uniprot/Q3MKY2,function:Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline; but is inactive toward other acetylated alkaloids.|catalytic activity:17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)|catalytic activity:17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline|biophysicochemical properties:0.7 mM for 17-O-acetylnorajmaline|biophysicochemical properties:0.12 mM for 17-O-acetylajmaline|biophysicochemical properties:Optimum pH is 8.0. Half maximum activity is seen at pH 6.5 and 9.8.|biophysicochemical properties:Optimum temperature is 53 degrees Celsius.|similarity:Belongs to the 'GDSL' lipolytic enzyme family.
Cluster-46257.0,NA,38.9774535098032,-5.84610650785897,1.09654245915447,-5.33140003750225,9.74584634679619E-08,2.36057789758659E-05,late,sup,NA,NA
Cluster-46730.0,RGP1_ARATH,11.1785755376446,-3.15202578733978,0.877538421269583,-3.59189490846403,0.00032828223995999,0.0156167848184868,late,sup,https://www.uniprot.org/uniprot/W8PVH6,function:UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides. Catalyzes the interconvertion of UDP-L-arabinopyranose (UDP-Arap) and UDP-L-arabinofuranose (UDP-Araf) in vitro. Preferentially catalyzes the formation of UDP-Arap from UDP-Araf. At thermodynamic equilibrium in vitro the ratio of the pyranose form over the furanose form is 95:5. Is not active on other UDP-sugars (UDP-Gal; UDP-Xyl; UDP-Glc; GDP-Man and GDP-Fuc) (PubMed:21478444). Functions redundantly with RGP2 and is essential for proper cell walls and pollen development. Probably involved in the formation of the pectocellulosic cell wall layer intine. Is probably active as heteromer in vivo (PubMed:17071651).|catalytic activity:UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose|cofactor:Mn(2+)|cofactor:Mg(2+)|subunit:Heteromers with RGP2; RGP3; RGP4 and RGP5.|subcellular location:Soluble and associated with peripheral membrane and endomembrane system.|subcellular location:Cytoplasm|subcellular location:Cytosol|subcellular location:Golgi apparatus|tissue specificity:Predominantly expressed in shoot and root apical meristems. Expressed in epidermal cells of leaves; inflorescence stems and seed coat. Expressed in pollen.|domain:The conserved DXD motif is involved in enzyme activity.|PTM:Reversibly glycosylated in vitro by UDP-glucose; UDP-xylose and UDP-galactose; but not UDP-mannose.|disruption phenotype:No visible phenotype under normal growth condition; but significant reduction in total cell wall arabinose. Rgp1 and rgp2 double mutant is male gametophyte lethal; with an arrest in pollen mitosis (PubMed:17071651). RNAi-mediated knockdown of both RGP1 and RGP2 causes severe developmental defects and strong reduction in total cell wall arabinose (PubMed:21478444).|similarity:Belongs to the RGP family.
Cluster-47011.0,NA,35.556621769632,-4.2744936441064,0.874375228711832,-4.88862619130207,1.01542098856572E-06,0.00015640440760772,late,sup,NA,NA
Cluster-49127.1,PDI22_ORYSJ,19.1136649871917,-1.15082421069388,0.399697128111874,-2.87924062934914,0.00398634047615839,0.0941821171321711,late,sup,https://www.uniprot.org/uniprot/A0A0P0V205,function:Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation; isomerization; and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis (By similarity).|catalytic activity:Catalyzes the rearrangement of -S-S- bonds in proteins.|subcellular location:Secreted|similarity:Belongs to the protein disulfide isomerase family.
Cluster-49142.0,RAD_ANTMA,4230.27811442411,-10.8142181110413,0.855503259793854,-12.6407678606007,1.25819175328419E-36,1.99612121658536E-32,late,sup,https://www.uniprot.org/uniprot/Q58FS3,function:Involved in the dorsovental asymmetry of flowers. Promotes dorsal identity.|subcellular location:Nucleus|tissue specificity:Specifically expressed in the dorsal region of developing flowers.|developmental stage:Early expressed at stage two (plastochrons 7 and 8); when the floral meristem comprised a loaf-shaped bulge of cells. Expression was in the dorsal region of the floral meristem. At stage four; when sepal primordia had emerged around the meristem dome; expression could be seen in the dorsal sepal primordium. At stage five; expressed in emerging dorsal primordia of whorls two and three. In older flower buds (stages seven and eight); expression was found mainly in the dorsal petals and staminode.|induction:Up-regulated by both CYC and DICH.|disruption phenotype:Radially symmetric flowers. Loss of functional stamens in dorsal positions. Organs reduction with five organs per whorl rather than six.
Cluster-49883.0,RGP1_PEA,4.42909316918204,-4.17252121987317,1.4226801627374,-2.93285963293729,0.00335855697637161,0.0849162006106118,late,sup,https://www.uniprot.org/uniprot/O04300,function:Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides (By similarity). Was initially shown to possess an autoglycosylating activity which is dependent on the presence of UDP-glucose and manganese (PubMed:9207152).|catalytic activity:UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose|cofactor:Mn(2+)|cofactor:Mg(2+)|activity regulation:Inhibited by inhibitor protein (IP) which may be a form of sucrose synthase.|subunit:Homopentamer or homohexamer.|subcellular location:Cell wall-associated; with highest concentrations on plasmodesmata. Also located in the Golgi apparatus.|subcellular location:Secreted|subcellular location:Cell wall|subcellular location:Cell junction|subcellular location:Plasmodesma|subcellular location:Golgi apparatus|domain:The conserved DXD motif is involved in enzyme activity.|PTM:Reversibly glycosylated by UDP-glucose; UDP-xylose and UDP-galactose; but not UDP-mannose.|similarity:Belongs to the RGP family.
Cluster-50283.0,NA,61.8125509903529,-1.07903471444543,0.341962527423875,-3.15541800025336,0.00160268310045555,0.0498560144877006,late,sup,NA,NA
Cluster-52182.2,NA,9.07321145872475,-1.99529932228138,0.569967504736679,-3.5007247004427,0.00046399489389229,0.0202232939329704,late,sup,NA,NA
Cluster-52592.0,COMT1_POPTM,11.8407209735322,-4.4355374245182,0.984135418792679,-4.50703972219559,6.57383305450295E-06,0.00072175682636463,late,sup,https://www.uniprot.org/uniprot/Q43094,function:Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.|catalytic activity:(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine|pathway:Aromatic compound metabolism; phenylpropanoid biosynthesis.|subunit:Homodimer.|tissue specificity:Xylem.|PTM:The N-terminus is blocked.|similarity:Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Cluster-53273.0,NA,190.912189645229,-1.3117622347708,0.27011589512005,-4.85629412585216,1.19603007509763E-06,0.00018157911140118,late,sup,NA,NA
Cluster-53657.0,PER12_ARATH,5.29656755428854,-3.25209229946824,0.989984903435954,-3.28499180965402,0.00101985336236955,0.036196808935107,late,sup,https://www.uniprot.org/uniprot/Q43734,function:Removal of H(2)O(2); oxidation of toxic reductants; biosynthesis and degradation of lignin; suberization; auxin catabolism; response to environmental stresses such as wounding; pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.|function:Exhibits a Ca(2+)-pectate binding affinity which could be interpreted in vivo as a specificity to interact with the pectic structure of the cell wall.|catalytic activity:2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O|cofactor:Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|cofactor:heme b|cofactor:Binds 2 calcium ions per subunit.|cofactor:Ca(2+)|subcellular location:Carboxy-terminal extension appears to target the protein to vacuoles.|subcellular location:Secreted|subcellular location:Vacuole|tissue specificity:Expressed in roots and leaves.|developmental stage:Expressed in the first stage of developing seeds.|induction:Induced either by incompatible fungal pathogen attack; or by methyl jasmonate; a plant defense-related signaling molecule.|miscellaneous:There are 73 peroxidase genes in A.thaliana.|similarity:Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Cluster-56526.0,NA,43.4671048105028,-2.32019976059356,0.383192587660922,-6.05491816727586,1.40489064876286E-09,5.64268104876526E-07,late,sup,NA,NA
Cluster-56526.1,NA,28.6081547207326,-9.30861568025128,1.16104875953856,-8.01742011588803,1.07989269776019E-15,1.80342080525952E-12,late,sup,NA,NA
Cluster-56526.2,NA,418.014203239517,-2.64667940870113,0.381479546914679,-6.93793266272564,3.97879271361985E-12,3.23710494367072E-09,late,sup,NA,NA
Cluster-56607.0,NA,6.71952170412079,-3.39721495277793,0.943534671190427,-3.60051946844918,0.00031758204691254,0.0152407340459519,late,sup,NA,NA
Cluster-57115.0,SWET5_ORYSJ,31.3775333136996,-2.31165258579303,0.725522712933997,-3.18618913589178,0.00144160319498917,0.0460645210241756,late,sup,https://www.uniprot.org/uniprot/A0A0P0WQZ4,function:Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Can transport galactose. Prevents growth but promotes senescence (PubMed:25988582; PubMed:24709840). Involved in regulating the crosstalk between sugar and auxin. Regulates negatively the auxin signaling pathway and translocation (PubMed:24709840).|subunit:Forms homooligomers and/or heterooligomers.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Mainly expressed in the floral organs at the heading stage; and also in stem; root; senescing leaves; stamen; pistil and hull.|similarity:Belongs to the SWEET sugar transporter family.
Cluster-57115.2,SWET5_ORYSJ,6.63788573175866,-4.04626765786709,1.1052661919362,-3.6608987838295,0.00025133203914314,0.0126583580984315,late,sup,https://www.uniprot.org/uniprot/A0A0P0WQZ4,function:Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Can transport galactose. Prevents growth but promotes senescence (PubMed:25988582; PubMed:24709840). Involved in regulating the crosstalk between sugar and auxin. Regulates negatively the auxin signaling pathway and translocation (PubMed:24709840).|subunit:Forms homooligomers and/or heterooligomers.|subcellular location:Cell membrane|subcellular location:Multi-pass membrane protein|tissue specificity:Mainly expressed in the floral organs at the heading stage; and also in stem; root; senescing leaves; stamen; pistil and hull.|similarity:Belongs to the SWEET sugar transporter family.
Cluster-57485.1,GASA6_ARATH,210.342943426522,-1.10678388957222,0.308817158346765,-3.58394557963465,0.00033844263019439,0.0160280368001018,late,sup,https://www.uniprot.org/uniprot/Q9CA50,function:Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination; flowering and seed maturation.|subcellular location:Secreted|PTM:Six disulfide bonds may be present.|similarity:Belongs to the GASA family.