Comparison,,Number of studies,Within-study bias,Reporting bias,Indirectness,Imprecision,Heterogeneity,Incoherence,Confidence rating,Reason(s) for downgrading, A:E,Moderate,6,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], A:F,Moderate,3,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], A:G,Very low,1,Major concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]",9 A:H,Low,3,Major concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Low,["Within-study bias"],3 B:E,Moderate,9,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"],16 B:F,Moderate,1,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], C:F,Moderate,7,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], D:G,Moderate,4,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], A:B,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", A:C,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", A:D,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", B:C,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", B:D,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", B:G,Very low,0,Major concerns,Low risk,No concerns,No concerns,Major concerns,No concerns,Very low,"[""Within-study bias"",""Heterogeneity""]", B:H,Low,0,Major concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Low,["Within-study bias"], C:D,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", C:E,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", C:G,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", C:H,Moderate,0,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], D:E,Moderate,0,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], D:F,Moderate,0,Some concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Moderate,["Within-study bias"], D:H,Low,0,Major concerns,Low risk,No concerns,No concerns,No concerns,No concerns,Low,["Within-study bias"], E:F,Very low,0,Some concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", E:G,Very low,0,Major concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", E:H,Very low,0,Major concerns,Low risk,No concerns,No concerns,Major concerns,No concerns,Very low,"[""Within-study bias"",""Heterogeneity""]", F:G,Very low,0,Major concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", F:H,Very low,0,Major concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]", G:H,Very low,0,Major concerns,Low risk,No concerns,Major concerns,No concerns,No concerns,Very low,"[""Within-study bias"",""Imprecision""]",