DDE:  Pathways related to data in the Comparative Toxicogenomics Database,,,,,,,
Pathway,Pathway ID,P-value,Corrected P-value,Annotated Genes Quantity,Genome Frequency,Annotated Genes,
Metabolism,REACT:R-HSA-1430728,5.87E-68,8.30E-65,136,2172/43037 genes: 5.05%,ABCB1|ABCB11|ABCC3|ABCG2|ABCG8|ACACA|ACADM|ACADS|ACOX1|ADIPOQ|AGT|AHR|AKR1B1|AKR1B10|AKR1C4|ALB|AMPD3|AOC3|APOB|APOE|APRT|ARG1|BLVRB|BPHL|CA2|CACNA1A|CACNA1C|CACNA1D|CACNB3|CARNS1|CAT|CD36|CD38|CD44|CGA|CKMT2|CLOCK|CPT1A|CREBBP|CRYL1|CSNK2A1|CYB5A|CYCS|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP26A1|CYP27A1|CYP2B6|CYP3A4|CYP7A1|CYP8B1|DDC|DIO2|DPYD|EBP|ELOVL2|ELOVL3|EPHX2|FABP3|FABP4|FASN|FBP1|FOLH1|FYN|GAPDH|GCLC|GLS|GLYAT|GPT|GPX1|GPX2|GPX4|GSR|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|HSD17B1|HSD17B4|IDI1|INMT|INS|LDLR|LHB|LIPF|ME1|MED1|MGST3|MSMO1|MT2A|NOS3|NR1H4|NUDT7|OGDH|OXCT1|PCK1|PKLR|PLA2G12A|PLA2G1B|POMC|POR|PPARG|PPARGC1A|PRELP|PTGS2|RELN|RPL17|RXRA|SHMT2|SLC10A2|SLC25A14|SLC25A37|SLC2A4|SMPD3|SQLE|SRD5A2|SREBF1|STAR|STS|STXBP1|SUCLG2|TPMT|TPO|TSHB|TTR|UGT2A3|UGT2B17|VNN1,
Immune System,REACT:R-HSA-168256,1.17E-63,1.66E-60,130,2118/43037 genes: 4.92%,ACTB|ACTG1|AMPD3|APAF1|APOB|APP|APRT|AREL1|ARG1|ATP8B4|BCL2|BCL2L1|C1R|CAMK2B|CAMK2G|CAPN1|CASP3|CASP4|CASP8|CASP9|CAT|CCND1|CD300LF|CD36|CD4|CD40LG|CD44|CD81|CD86|CFL1|CHGA|CLU|CREB1|CREBBP|CREG1|CSTB|CTNNB1|CTSD|CXCL8|CYBA|DLG4|DNAJC5|EGF|EGFR|EPX|ERBB2|ERBB3|ERBB4|FASLG|FBXO30|FGFR4|FN1|FOS|FOXO3|FOXO4|FTL|FYN|GDNF|GFRA1|GFRA4|GH1|GRIN1|GRIN2B|GSK3B|GSN|HSPA1B|IFITM2|IFNG|IGF2R|IL12RB2|IL1B|IL4|IL6|INS|IRS2|ITGAL|JUN|KIT|KLC1|LRRC7|MAPK1|MAPK3|MMP8|MMP9|MPO|MT2A|MYC|NCF1|NCF2|NCF4|NF1|NFKB1|NFKBIA|NFKBIB|NOS2|NOS3|NR4A1|NRG1|ORM1|PDGFRA|PDGFRB|POMC|PRDX6|PRKN|PRL|PTGS2|PYCARD|REL|RELA|RET|RETN|RIPK2|RPS6KB2|SLPI|SPTBN2|STAT3|STAT5B|STBD1|SYNGAP1|TGFB1|TLR9|TNF|TNFRSF11B|TNFRSF1B|TP53|TSC2|TTR|VASP|VIM|VNN1,
Innate Immune System,REACT:R-HSA-168249,4.08E-57,5.77E-54,100,1298/43037 genes: 3.02%,ACTB|ACTG1|AMPD3|APAF1|APOB|APP|APRT|ARG1|ATP8B4|BCL2|BCL2L1|C1R|CAMK2B|CAMK2G|CAPN1|CASP4|CASP8|CASP9|CAT|CD36|CD4|CD44|CD86|CFL1|CHGA|CLU|CREB1|CREBBP|CREG1|CSTB|CTNNB1|CTSD|CYBA|DLG4|DNAJC5|EGF|EGFR|EPX|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOS|FOXO3|FOXO4|FTL|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|GSN|HSPA1B|IGF2R|IL1B|INS|IRS2|ITGAL|JUN|KIT|LRRC7|MAPK1|MAPK3|MMP8|MMP9|MPO|NCF1|NCF2|NCF4|NF1|NFKB1|NFKBIA|NFKBIB|NOS2|NOS3|NR4A1|NRG1|ORM1|PDGFRA|PDGFRB|PRDX6|PYCARD|RELA|RET|RETN|RIPK2|RPS6KB2|SLPI|SPTBN2|STBD1|SYNGAP1|TLR9|TNFRSF1B|TP53|TSC2|TTR|VNN1,
Signal Transduction,REACT:R-HSA-162582,2.57E-50,3.64E-47,126,2587/43037 genes: 6.01%,ACTB|ACTG1|ACVR1C|ADM|AGT|AKR1B10|AKR1C4|APOB|APOE|APP|AR|AVP|BCL2L11|CAMK2B|CAMK2G|CASP3|CASP8|CASP9|CCND1|CD86|CGA|CHN2|CPT1A|CREB1|CREBBP|CSNK2A1|CTNNB1|CTTN|CXCL8|CYBA|CYP26A1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|ESR1|FAS|FASLG|FGFR4|FN1|FOXO3|FOXO4|FSHB|FSHR|FYN|GDNF|GFRA1|GFRA4|GLI1|GNRH1|GRIN1|GRIN2B|GSK3B|HDAC1|HNRNPH1|HSD17B1|HSPB1|IGF1|IGF1R|IGF2|IL6|INHBB|INS|IRS2|JUN|KIT|KLC1|KLK3|LDLR|LEP|LHB|MAPK1|MAPK3|MMP9|MYC|NCF1|NCF2|NCF4|NF1|NFKB1|NFKBIA|NOS3|NOTCH2|NOTCH3|NOTCH4|NOX1|NR3C1|NR4A1|NRG1|NTRK1|NTRK2|OXT|PARP1|PDGFRA|PDGFRB|PFN1|PGR|POMC|PTCH1|PTCH2|RACK1|RDH12|REEP6|RELA|RET|RIPK2|RPS6KB2|RXRA|RXRB|SMPD3|SPTBN2|STAT3|STAT5B|SYNGAP1|TGFB1|TLR9|TNF|TNFRSF10B|TP53|TRHR|TSC2|TSHB|TTR|YWHAG,
Developmental Biology,REACT:R-HSA-1266738,4.08E-50,5.77E-47,86,1076/43037 genes: 2.50%,ACTB|ACTG1|ACVR1C|ADIPOQ|CACNA1C|CACNA1D|CACNA1G|CACNA1I|CACNB1|CACNB3|CACNG2|CAMK2B|CAMK2G|CAPN1|CD36|CDH2|CEBPA|CEBPB|CFL1|CREB1|CREBBP|CSNK2A1|CTNNB1|DCC|DLG1|DLG4|EGF|EGFR|EPHA3|EPHA8|ERBB2|ERBB3|ERBB4|FABP4|FGFR4|FN1|FOXO3|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|JUN|KIT|KRT18|KRT19|KRT71|LEP|MAPK1|MAPK3|MED1|MMP9|NF1|NFKB1|NR5A1|NRCAM|NRG1|PCK1|PDGFRA|PDGFRB|PFN1|PKLR|PLXND1|PPARG|PPARGC1A|RDX|RELA|RET|ROBO1|RRAS|RXRA|SCN5A|SLC2A4|SLIT1|SPTBN2|SREBF1|STAT3|SYNGAP1|TGFB1|TNF|UNC5B|VASP,
Pathways in cancer,KEGG:hsa05200,1.44E-43,2.04E-40,54,395/43037 genes: 0.92%,AR|BAX|BCL2|BCL2L1|BID|CASP3|CASP8|CASP9|CCND1|CEBPA|CREBBP|CTNNB1|CXCL8|CYCS|DCC|EGF|EGFR|ERBB2|FAS|FASLG|FN1|FOS|GLI1|GSK3B|HDAC1|IGF1|IGF1R|IL6|JUN|KIT|KLK3|MAPK1|MAPK3|MMP9|MYC|NFKB1|NFKBIA|NOS2|NTRK1|PDGFRA|PDGFRB|PPARG|PTCH1|PTCH2|PTGS2|RELA|RET|RUNX1|RXRA|RXRB|STAT3|STAT5B|TGFB1|TP53,
Metabolism of lipids and lipoproteins,REACT:R-HSA-556833,1.07E-41,1.51E-38,69,814/43037 genes: 1.89%,ABCB11|ABCC3|ABCG8|ACACA|ACADM|ACADS|ACOX1|AGT|AHR|AKR1B1|AKR1C4|ALB|APOB|APOE|CD36|CGA|CLOCK|CPT1A|CREBBP|CSNK2A1|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP27A1|CYP7A1|CYP8B1|EBP|ELOVL2|ELOVL3|EPHX2|FABP3|FABP4|FASN|FYN|GPX1|GPX2|GPX4|HSD17B1|HSD17B4|IDI1|LDLR|LHB|LIPF|ME1|MED1|MSMO1|NR1H4|NUDT7|OXCT1|PLA2G12A|PLA2G1B|POMC|PPARG|PPARGC1A|PTGS2|RELN|RXRA|SLC10A2|SMPD3|SQLE|SRD5A2|SREBF1|STAR|STS,
Signaling by Interleukins,REACT:R-HSA-449147,3.54E-40,5.01E-37,57,528/43037 genes: 1.23%,BCL2|BCL2L1|CAMK2B|CAMK2G|CASP3|CCND1|CD36|CD4|CD86|CXCL8|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FASLG|FGFR4|FN1|FOS|FOXO3|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IL12RB2|IL1B|IL4|IL6|IRS2|KIT|MAPK1|MAPK3|MMP9|MYC|NF1|NFKB1|NOS2|NRG1|PDGFRA|PDGFRB|POMC|PTGS2|RELA|RET|RIPK2|SPTBN2|STAT3|STAT5B|SYNGAP1|TGFB1|TNF|TNFRSF1B|TP53|VIM,
Cytokine Signaling in Immune system,REACT:R-HSA-1280215,1.66E-39,2.35E-36,65,760/43037 genes: 1.77%,BCL2|BCL2L1|CAMK2B|CAMK2G|CASP3|CCND1|CD36|CD4|CD40LG|CD44|CD86|CXCL8|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FASLG|FGFR4|FN1|FOS|FOXO3|FYN|GDNF|GFRA1|GFRA4|GH1|GRIN1|GRIN2B|IFITM2|IFNG|IL12RB2|IL1B|IL4|IL6|IRS2|KIT|MAPK1|MAPK3|MMP9|MT2A|MYC|NF1|NFKB1|NOS2|NRG1|PDGFRA|PDGFRB|POMC|PRL|PTGS2|RELA|RET|RIPK2|SPTBN2|STAT3|STAT5B|SYNGAP1|TGFB1|TNF|TNFRSF11B|TNFRSF1B|TP53|VIM,
MAPK signaling pathway,KEGG:hsa04010,7.99E-39,1.13E-35,43,255/43037 genes: 0.59%,BDNF|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1G|CACNA1I|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CASP3|DDIT3|EGF|EGFR|FAS|FASLG|FGFR4|FOS|GADD45B|HSPA1B|HSPA2|HSPB1|IL1B|JUN|MAPK1|MAPK3|MKNK2|MYC|NF1|NFKB1|NR4A1|NTRK1|NTRK2|PDGFRA|PDGFRB|RELA|RRAS|TGFB1|TNF|TP53,
Apoptosis,KEGG:hsa04210,1.98E-38,2.80E-35,35,138/43037 genes: 0.32%,ACTB|ACTG1|APAF1|BAK1|BAX|BCL2|BCL2L1|BCL2L11|BID|CAPN1|CASP12|CASP3|CASP8|CASP9|CTSD|CYCS|DDIT3|FAS|FASLG|FOS|GADD45B|HRK|JUN|LMNB2|MAPK1|MAPK3|NFKB1|NFKBIA|NTRK1|PARP1|PMAIP1|RELA|TNF|TNFRSF10B|TP53,
Axon guidance,REACT:R-HSA-422475,6.26E-36,8.85E-33,54,550/43037 genes: 1.28%,ACTB|ACTG1|CACNA1C|CACNA1D|CACNA1G|CACNA1I|CACNB1|CACNB3|CAMK2B|CAMK2G|CFL1|CREB1|CSNK2A1|DCC|DLG1|DLG4|EGF|EGFR|EPHA3|EPHA8|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|IRS2|KIT|MAPK1|MAPK3|MMP9|NF1|NRCAM|NRG1|PDGFRA|PDGFRB|PFN1|PLXND1|RDX|RET|ROBO1|RRAS|SCN5A|SLIT1|SPTBN2|SYNGAP1|UNC5B|VASP,
Platinum drug resistance,KEGG:hsa01524,5.06E-35,7.14E-32,27,73/43037 genes: 0.17%,ABCC2|APAF1|BAK1|BAX|BCL2|BCL2L1|BID|BRCA1|CASP3|CASP8|CASP9|CYCS|ERBB2|FAS|FASLG|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MAPK1|MAPK3|MGST3|PMAIP1|TP53|XPA,
Signalling by NGF,REACT:R-HSA-166520,1.71E-32,2.42E-29,48,477/43037 genes: 1.11%,BCL2L11|CAMK2B|CAMK2G|CASP3|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|HDAC1|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NFKB1|NFKBIA|NR4A1|NRG1|NTRK1|NTRK2|PDGFRA|PDGFRB|RELA|RET|RIPK2|RPS6KB2|SPTBN2|STAT3|SYNGAP1|TP53|TSC2,
Fc epsilon receptor (FCERI) signaling,REACT:R-HSA-2454202,2.06E-31,2.92E-28,43,378/43037 genes: 0.88%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOS|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|JUN|KIT|MAPK1|MAPK3|NF1|NFKB1|NFKBIA|NR4A1|NRG1|PDGFRA|PDGFRB|RELA|RET|RPS6KB2|SPTBN2|SYNGAP1|TP53|TSC2,
Signaling by SCF-KIT,REACT:R-HSA-1433557,3.61E-31,5.10E-28,41,337/43037 genes: 0.78%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|MMP9|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|STAT3|STAT5B|SYNGAP1|TP53|TSC2,
Disease,REACT:R-HSA-1643685,9.38E-30,1.33E-26,58,860/43037 genes: 2.00%,ACACA|ALB|APP|AVP|BCL2L11|CAPN1|CASP9|CD36|CD4|CD86|CREB1|CREBBP|CTDP1|CTNNB1|CYP11A1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FASLG|FGFR4|FN1|FOXO3|FOXO4|FYN|GSK3B|HDAC1|IRS2|JUN|KIT|MAPK1|MAPK3|MYC|NF1|NFKB1|NFKBIA|NFKBIB|NOTCH2|NOTCH3|NOTCH4|NR4A1|NRG1|PDGFRA|PDGFRB|POMC|PRDX1|PRDX2|PRELP|RELA|RPL17|RPS6KB2|STAT3|STAT5B|SYNGAP1|TGFB1|TSC2|TTR,
Downstream signal transduction,REACT:R-HSA-186763,2.89E-29,4.09E-26,40,352/43037 genes: 0.82%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|STAT3|STAT5B|SYNGAP1|TP53|TSC2,
Hepatitis B,KEGG:hsa05161,7.15E-29,1.01E-25,29,144/43037 genes: 0.33%,APAF1|BAX|BCL2|CASP12|CASP3|CASP8|CASP9|CCND1|CREB1|CREBBP|CXCL8|CYCS|FAS|FASLG|FOS|IL6|JUN|MAPK1|MAPK3|MMP9|MYC|NFKB1|NFKBIA|RELA|STAT3|STAT5B|TGFB1|TNF|TP53,
Metabolic pathways,KEGG:hsa01100,7.68E-29,1.08E-25,68,1270/43037 genes: 2.95%,ACACA|ACADM|ACADS|ACOX1|AKR1B1|AKR1B10|AKR1C4|ALPL|AMPD3|AOC3|APRT|ARG1|BLVRB|CD38|CKMT2|CRYL1|CYCS|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP21A2|CYP26A1|CYP27A1|CYP2B6|CYP3A4|CYP7A1|CYP8B1|DDC|DNMT1|DNMT3A|DPYD|EBP|EPHX2|FASN|FBP1|FOLH1|GAPDH|GCLC|GLS|GPT|HSD17B1|HSD17B4|IDI1|LIPF|ME1|MSMO1|NOS2|NOS3|OGDH|PCK1|PKLR|PLA2G12A|PLA2G1B|PRDX6|PTGS2|RDH12|RGN|SHMT2|SMPD3|SQLE|SUCLG2|TPO|TRAK2|UGT2A3|UGT2B17,
NGF signalling via TRKA from the plasma membrane,REACT:R-HSA-187037,9.29E-29,1.31E-25,41,387/43037 genes: 0.90%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|NTRK1|NTRK2|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|STAT3|SYNGAP1|TP53|TSC2,
PI3K-Akt signaling pathway,KEGG:hsa04151,1.15E-28,1.63E-25,39,341/43037 genes: 0.79%,BCL2|BCL2L1|BCL2L11|BRCA1|CASP9|CCND1|CREB1|EGF|EGFR|EPO|FASLG|FGFR4|FN1|FOXO3|GH1|GSK3B|IGF1|IGF1R|IL4|IL6|INS|KIT|MAPK1|MAPK3|MYC|NFKB1|NOS3|NR4A1|PCK1|PDGFRA|PDGFRB|PRL|RELA|RELN|RPS6KB2|RXRA|TP53|TSC2|YWHAG,
Proteoglycans in cancer,KEGG:hsa05205,3.52E-28,4.97E-25,32,203/43037 genes: 0.47%,ACTB|ACTG1|CAMK2B|CAMK2G|CASP3|CCND1|CD44|CTNNB1|CTTN|EGFR|ERBB2|ERBB3|ERBB4|ESR1|FAS|FASLG|FN1|IGF1|IGF1R|IGF2|MAPK1|MAPK3|MMP9|MYC|PTCH1|RDX|RPS6KB2|RRAS|STAT3|TGFB1|TNF|TP53,
Signaling by PDGF,REACT:R-HSA-186797,3.77E-28,5.33E-25,40,376/43037 genes: 0.87%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|STAT3|STAT5B|SYNGAP1|TP53|TSC2,
Biological oxidations,REACT:R-HSA-211859,4.22E-28,5.97E-25,33,223/43037 genes: 0.52%,AHR|AOC3|BPHL|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP26A1|CYP27A1|CYP2B6|CYP3A4|CYP7A1|CYP8B1|GCLC|GLYAT|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3|NR1H4|POMC|POR|RXRA|TPMT|UGT2A3|UGT2B17,
Prostate cancer,KEGG:hsa05215,1.07E-27,1.51E-24,24,87/43037 genes: 0.20%,AR|BCL2|CASP9|CCND1|CREB1|CREBBP|CTNNB1|EGF|EGFR|ERBB2|GSK3B|IGF1|IGF1R|INS|KLK3|MAPK1|MAPK3|NFKB1|NFKBIA|PDGFRA|PDGFRB|RELA|SRD5A2|TP53,
Fluid shear stress and atherosclerosis,KEGG:hsa05418,1.21E-27,1.70E-24,28,142/43037 genes: 0.33%,ACTB|ACTG1|BCL2|CTNNB1|CYBA|FOS|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|IFNG|IL1B|JUN|MGST3|MMP9|NCF1|NCF2|NFE2L2|NFKB1|NOS3|NOX1|RELA|SUMO2|TNF|TP53|TRPV4,
HIF-1 signaling pathway,KEGG:hsa04066,1.74E-27,2.46E-24,25,101/43037 genes: 0.23%,BCL2|CAMK2B|CAMK2G|CREBBP|EGF|EGFR|EPO|ERBB2|GAPDH|IFNG|IGF1|IGF1R|IL6|INS|MAPK1|MAPK3|MKNK2|NFKB1|NOS2|NOS3|NOX1|RELA|RPS6KB2|STAT3|TF,
DAP12 signaling,REACT:R-HSA-2424491,7.61E-27,1.07E-23,38,356/43037 genes: 0.83%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|SYNGAP1|TP53|TSC2,
Signaling by EGFR,REACT:R-HSA-177929,1.72E-26,2.43E-23,38,364/43037 genes: 0.85%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|SYNGAP1|TP53|TSC2,
NCAM signaling for neurite out-growth,REACT:R-HSA-375165,3.34E-26,4.71E-23,34,276/43037 genes: 0.64%,CACNA1C|CACNA1D|CACNA1G|CACNA1I|CACNB1|CACNB3|CAMK2B|CAMK2G|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
DAP12 interactions,REACT:R-HSA-2172127,3.46E-26,4.89E-23,38,371/43037 genes: 0.86%,CAMK2B|CAMK2G|CASP9|CD86|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RET|RPS6KB2|SPTBN2|SYNGAP1|TP53|TSC2,
PI3K/AKT activation,REACT:R-HSA-198203,4.09E-26,5.78E-23,26,128/43037 genes: 0.30%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NR4A1|NRG1|NTRK1|PDGFRA|PDGFRB|RPS6KB2|TP53|TSC2,
Downstream signaling events of B Cell Receptor (BCR),REACT:R-HSA-1168372,4.96E-26,7.01E-23,30,197/43037 genes: 0.46%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NR4A1|NRG1|PDGFRA|PDGFRB|REL|RELA|RPS6KB2|TP53|TSC2,
Amyotrophic lateral sclerosis (ALS),KEGG:hsa05014,4.40E-25,6.22E-22,19,51/43037 genes: 0.12%,APAF1|BAX|BCL2|BCL2L1|BID|CASP12|CASP3|CASP9|CAT|CYCS|GPX1|GRIA2|GRIN1|GRIN2B|SLC1A2|SOD1|TNF|TNFRSF1B|TP53,
Generic Transcription Pathway,REACT:R-HSA-212436,4.48E-25,6.32E-22,53,873/43037 genes: 2.03%,APAF1|APOE|AR|BAX|BID|BRCA1|BTG2|CGA|CREBBP|CSNK2A1|CTDP1|CYCS|EGFR|ERBB2|ESR1|ESR2|FAS|FOS|GLS|GPX2|GSR|HDAC1|HUS1|JUN|KIT|MED1|MYC|NOTCH2|NOTCH3|NOTCH4|NR1H4|NR1I2|NR1I3|NR3C1|NR3C2|NR4A1|NR4A2|NR5A1|PARP1|PGR|PLK3|PMAIP1|PPARG|PRDX1|PRDX2|RXRA|RXRB|THRA|THRB|TNFRSF10B|TP53|TSC2|YWHAG,
PIP3 activates AKT signaling,REACT:R-HSA-1257604,5.60E-25,7.91E-22,25,125/43037 genes: 0.29%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NR4A1|NRG1|PDGFRA|PDGFRB|RPS6KB2|TP53|TSC2,
GAB1 signalosome,REACT:R-HSA-180292,1.05E-24,1.48E-21,25,128/43037 genes: 0.30%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NR4A1|NRG1|PDGFRA|PDGFRB|RPS6KB2|TP53|TSC2,
Non-alcoholic fatty liver disease (NAFLD),KEGG:hsa04932,2.63E-24,3.71E-21,26,149/43037 genes: 0.35%,ADIPOQ|BAX|BCL2L11|BID|CASP3|CASP8|CEBPA|CXCL8|CYCS|DDIT3|FAS|FASLG|GSK3B|IL1B|IL6|INS|IRS2|JUN|LEP|NFKB1|PKLR|RELA|RXRA|SREBF1|TGFB1|TNF,
EGFR tyrosine kinase inhibitor resistance,KEGG:hsa01521,5.16E-24,7.29E-21,21,79/43037 genes: 0.18%,BAX|BCL2|BCL2L1|BCL2L11|EGF|EGFR|ERBB2|ERBB3|FOXO3|GSK3B|IGF1|IGF1R|IL6|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RPS6KB2|STAT3,
Role of LAT2/NTAL/LAB on calcium mobilization,REACT:R-HSA-2730905,6.29E-24,8.89E-21,25,137/43037 genes: 0.32%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NR4A1|NRG1|PDGFRA|PDGFRB|RPS6KB2|TP53|TSC2,
MicroRNAs in cancer,KEGG:hsa05206,6.40E-24,9.04E-21,33,299/43037 genes: 0.69%,ABCB1|BAK1|BCL2|BCL2L11|BCL2L2|BRCA1|CASP3|CCND1|CD44|CREBBP|CYP1B1|DNMT1|DNMT3A|EGFR|ERBB2|ERBB3|GLS|HDAC1|IRS2|MAPK1|MMP9|MYC|NFKB1|NOTCH2|NOTCH3|NOTCH4|PDGFRA|PDGFRB|PTGS2|RDX|STAT3|TP53|VIM,
Neuronal System,REACT:R-HSA-112316,6.78E-24,9.57E-21,35,349/43037 genes: 0.81%,CACNA1A|CACNA1B|CACNA2D3|CACNB1|CACNB3|CACNG2|CAMK2B|CAMK2G|CREB1|DLG1|DLG4|DLGAP3|DLGAP4|DNAJC5|GABRA4|GABRB1|GLS|GRIA2|GRIA4|GRIK1|GRIK2|GRIN1|GRIN2B|GRIP1|MAPK1|NLGN1|NRXN1|NRXN2|PPFIA3|RRAS|SHANK2|SLC1A2|SLC1A6|SLC6A3|STXBP1,
Signaling by the B Cell Receptor (BCR),REACT:R-HSA-983705,9.00E-24,1.27E-20,30,234/43037 genes: 0.54%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|KIT|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NR4A1|NRG1|PDGFRA|PDGFRB|REL|RELA|RPS6KB2|TP53|TSC2,
Endocrine resistance,KEGG:hsa01522,1.22E-23,1.72E-20,22,95/43037 genes: 0.22%,ABCB11|BAX|BCL2|BIK|CCND1|EGFR|ERBB2|ESR1|ESR2|FOS|IGF1|IGF1R|JUN|MAPK1|MAPK3|MED1|MMP9|NOTCH2|NOTCH3|NOTCH4|RPS6KB2|TP53,
VEGFA-VEGFR2 Pathway,REACT:R-HSA-4420097,1.26E-23,1.77E-20,34,330/43037 genes: 0.77%,CAMK2B|CAMK2G|CTNNB1|CYBA|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|HSPB1|IRS2|KIT|MAPK1|MAPK3|NCF1|NCF2|NCF4|NF1|NOS3|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Transmission across Chemical Synapses,REACT:R-HSA-112315,1.53E-23,2.16E-20,29,217/43037 genes: 0.50%,CACNA1A|CACNA1B|CACNA2D3|CACNB1|CACNB3|CACNG2|CAMK2B|CAMK2G|CREB1|DLG1|DLG4|DNAJC5|GABRA4|GABRB1|GLS|GRIA2|GRIA4|GRIK1|GRIK2|GRIN1|GRIN2B|GRIP1|MAPK1|PPFIA3|RRAS|SLC1A2|SLC1A6|SLC6A3|STXBP1,
Tuberculosis,KEGG:hsa05152,1.68E-23,2.37E-20,27,178/43037 genes: 0.41%,APAF1|BAX|BCL2|BID|CAMK2B|CAMK2G|CASP3|CASP8|CASP9|CEBPB|CREB1|CREBBP|CTSD|CYCS|IFNG|IL1B|IL6|MAPK1|MAPK3|NFKB1|NOS2|PLK3|RELA|RIPK2|TGFB1|TLR9|TNF,
Nuclear Receptor transcription pathway,REACT:R-HSA-383280,2.54E-23,3.58E-20,18,51/43037 genes: 0.12%,AR|ESR1|ESR2|MED1|NR1H4|NR1I2|NR1I3|NR3C1|NR3C2|NR4A1|NR4A2|NR5A1|PGR|PPARG|RXRA|RXRB|THRA|THRB,
Signaling by VEGF,REACT:R-HSA-194138,2.75E-23,3.88E-20,34,338/43037 genes: 0.79%,CAMK2B|CAMK2G|CTNNB1|CYBA|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|HSPB1|IRS2|KIT|MAPK1|MAPK3|NCF1|NCF2|NCF4|NF1|NOS3|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
MAPK family signaling cascades,REACT:R-HSA-5683057,3.15E-23,4.46E-20,32,290/43037 genes: 0.67%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|HSPB1|IL6|IRS2|JUN|KIT|MAPK1|MAPK3|MYC|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Interleukin-4 and 13 signaling,REACT:R-HSA-6785807,3.56E-23,5.03E-20,23,114/43037 genes: 0.26%,BCL2|BCL2L1|CCND1|CD36|CXCL8|FASLG|FN1|FOS|FOXO3|IL1B|IL4|IL6|MMP9|MYC|NOS2|POMC|PTGS2|STAT3|TGFB1|TNF|TNFRSF1B|TP53|VIM,
Diseases of signal transduction,REACT:R-HSA-5663202,4.77E-23,6.75E-20,35,370/43037 genes: 0.86%,BCL2L11|CASP9|CD86|CREB1|CREBBP|CTNNB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOXO3|FOXO4|FYN|GSK3B|HDAC1|IRS2|KIT|MAPK1|MAPK3|MYC|NF1|NR4A1|NRG1|PDGFRA|PDGFRB|RPS6KB2|STAT3|STAT5B|SYNGAP1|TGFB1|TSC2|TTR,
Thyroid hormone signaling pathway,KEGG:hsa04919,5.45E-23,7.70E-20,23,116/43037 genes: 0.27%,ACTB|ACTG1|CASP9|CCND1|CREBBP|CTNNB1|DIO2|ESR1|GSK3B|HDAC1|MAPK1|MAPK3|MED1|MYC|NOTCH2|NOTCH3|NOTCH4|RXRA|RXRB|THRA|THRB|TP53|TSC2,
IGF1R signaling cascade,REACT:R-HSA-2428924,7.35E-23,1.04E-19,32,298/43037 genes: 0.69%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IGF1|IGF1R|IGF2|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
IRS-related events triggered by IGF1R,REACT:R-HSA-2428928,7.35E-23,1.04E-19,32,298/43037 genes: 0.69%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IGF1|IGF1R|IGF2|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),REACT:R-HSA-2404192,8.15E-23,1.15E-19,32,299/43037 genes: 0.69%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IGF1|IGF1R|IGF2|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
Signaling by Leptin,REACT:R-HSA-2586552,9.12E-23,1.29E-19,30,253/43037 genes: 0.59%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|LEP|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|STAT3|STAT5B|SYNGAP1,
PI3K/AKT Signaling in Cancer,REACT:R-HSA-2219528,1.06E-22,1.50E-19,21,90/43037 genes: 0.21%,CASP9|CD86|CREB1|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FOXO3|FOXO4|FYN|GSK3B|IRS2|KIT|NR4A1|NRG1|PDGFRA|PDGFRB|RPS6KB2|TSC2,
Detoxification of Reactive Oxygen Species,REACT:R-HSA-3299685,2.27E-22,3.21E-19,16,38/43037 genes: 0.09%,CAT|CYBA|CYCS|GPX1|GPX2|GPX5|GPX6|GSR|NCF1|NCF2|NCF4|PRDX1|PRDX2|PRDX6|SOD1|TXNRD2,
Cytochrome P450 - arranged by substrate type,REACT:R-HSA-211897,2.59E-22,3.67E-19,19,68/43037 genes: 0.16%,AHR|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP26A1|CYP27A1|CYP2B6|CYP3A4|CYP7A1|CYP8B1|NR1H4|POMC|POR|RXRA,
Adaptive Immune System,REACT:R-HSA-1280218,3.72E-22,5.26E-19,48,818/43037 genes: 1.90%,AREL1|CASP9|CD300LF|CD36|CD4|CD40LG|CD81|CD86|CREB1|CTSD|CYBA|EGF|EGFR|ERBB2|ERBB3|ERBB4|FBXO30|FGFR4|FOXO3|FOXO4|FYN|GSK3B|INS|IRS2|ITGAL|KIT|KLC1|MAPK1|MAPK3|NCF1|NCF2|NCF4|NFKB1|NFKBIA|NFKBIB|NR4A1|NRG1|PDGFRA|PDGFRB|PRKN|REL|RELA|RIPK2|RPS6KB2|SPTBN2|TP53|TSC2|VASP,
Leishmaniasis,KEGG:hsa05140,8.78E-22,1.24E-18,19,72/43037 genes: 0.17%,CYBA|FOS|IFNG|IL1B|IL4|JUN|MAPK1|MAPK3|NCF1|NCF2|NCF4|NFKB1|NFKBIA|NFKBIB|NOS2|PTGS2|RELA|TGFB1|TNF,
Endogenous sterols,REACT:R-HSA-211976,4.44E-21,6.27E-18,14,28/43037 genes: 0.07%,AHR|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1B1|CYP21A2|CYP27A1|CYP7A1|CYP8B1|NR1H4|POMC|RXRA,
IL-17 signaling pathway,KEGG:hsa04657,6.48E-21,9.16E-18,20,93/43037 genes: 0.22%,CASP3|CASP8|CEBPB|CXCL8|FOS|GSK3B|IFNG|IL1B|IL4|IL6|JUN|MAPK1|MAPK3|MMP13|MMP9|NFKB1|NFKBIA|PTGS2|RELA|TNF,
Phase 1 - Functionalization of compounds,REACT:R-HSA-211945,7.95E-21,1.12E-17,21,109/43037 genes: 0.25%,AHR|AOC3|BPHL|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP26A1|CYP27A1|CYP2B6|CYP3A4|CYP7A1|CYP8B1|NR1H4|POMC|POR|RXRA,
FCERI mediated MAPK activation,REACT:R-HSA-2871796,8.70E-21,1.23E-17,29,271/43037 genes: 0.63%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FOS|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|JUN|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Insulin receptor signalling cascade,REACT:R-HSA-74751,9.75E-21,1.38E-17,30,297/43037 genes: 0.69%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
Breast cancer,KEGG:hsa05224,9.78E-21,1.38E-17,23,144/43037 genes: 0.33%,BRCA1|CCND1|CTNNB1|EGF|EGFR|ERBB2|ESR1|ESR2|FOS|GSK3B|IGF1|IGF1R|JUN|KIT|MAPK1|MAPK3|MYC|NOTCH2|NOTCH3|NOTCH4|PGR|RPS6KB2|TP53,
ARMS-mediated activation,REACT:R-HSA-170984,1.07E-20,1.51E-17,28,249/43037 genes: 0.58%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Signalling to p38 via RIT and RIN,REACT:R-HSA-187706,1.07E-20,1.51E-17,28,249/43037 genes: 0.58%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Frs2-mediated activation,REACT:R-HSA-170968,1.19E-20,1.68E-17,28,250/43037 genes: 0.58%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Adipocytokine signaling pathway,KEGG:hsa04920,1.32E-20,1.87E-17,18,69/43037 genes: 0.16%,ADIPOQ|CD36|CPT1A|IRS2|LEP|NFKB1|NFKBIA|NFKBIB|PCK1|POMC|PPARGC1A|RELA|RXRA|RXRB|SLC2A4|STAT3|TNF|TNFRSF1B,
MAPK1/MAPK3 signaling,REACT:R-HSA-5684996,1.33E-20,1.88E-17,28,251/43037 genes: 0.58%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IL6|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Prolonged ERK activation events,REACT:R-HSA-169893,1.48E-20,2.09E-17,28,252/43037 genes: 0.59%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Toxoplasmosis,KEGG:hsa05145,1.76E-20,2.49E-17,21,113/43037 genes: 0.26%,BCL2|BCL2L1|CASP3|CASP8|CASP9|CD40LG|CYCS|HSPA1B|HSPA2|IFNG|LDLR|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NOS2|RELA|STAT3|TGFB1|TNF,
Signalling to RAS,REACT:R-HSA-167044,2.27E-20,3.21E-17,28,256/43037 genes: 0.59%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
FoxO signaling pathway,KEGG:hsa04068,2.61E-20,3.69E-17,22,132/43037 genes: 0.31%,BCL2L11|CAT|CCND1|CREBBP|EGF|EGFR|FASLG|FOXO3|FOXO4|GADD45B|IGF1|IGF1R|IL6|INS|IRS2|MAPK1|MAPK3|PCK1|PLK3|SLC2A4|STAT3|TGFB1,
Measles,KEGG:hsa05162,3.10E-20,4.38E-17,22,133/43037 genes: 0.31%,CCND1|CSNK2A1|FAS|FASLG|FYN|GSK3B|HSPA1B|HSPA2|IFNG|IL1B|IL4|IL6|NFKB1|NFKBIA|NFKBIB|RACK1|RELA|STAT3|STAT5B|TLR9|TNFRSF10B|TP53,
Cellular responses to stress,REACT:R-HSA-2262752,3.11E-20,4.39E-17,35,451/43037 genes: 1.05%,CAMK2B|CAMK2G|CAT|CEBPB|CREBBP|CXCL8|CYBA|CYCS|EPO|FOS|GPX1|GPX2|GPX5|GPX6|GSK3B|GSR|HSPA1B|HSPA2|IL6|JUN|MAPK1|MAPK3|NCF1|NCF2|NCF4|NFKB1|PRDX1|PRDX2|PRDX6|RELA|SOD1|STAT3|TP53|TSC2|TXNRD2,
Alzheimer's disease,KEGG:hsa05010,3.27E-20,4.63E-17,24,171/43037 genes: 0.40%,APAF1|APOE|APP|ATF6|BACE1|BACE2|BID|CACNA1C|CACNA1D|CAPN1|CASP12|CASP3|CASP8|CASP9|CYCS|FAS|GAPDH|GRIN1|GRIN2B|GSK3B|IL1B|MAPK1|MAPK3|TNF,
Interleukin-2 signaling,REACT:R-HSA-451927,4.26E-20,6.02E-17,28,262/43037 genes: 0.61%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|STAT5B|SYNGAP1,
Influenza A,KEGG:hsa05164,4.34E-20,6.13E-17,24,173/43037 genes: 0.40%,ACTB|ACTG1|CASP9|CREBBP|CXCL8|CYCS|FAS|FASLG|GSK3B|HSPA1B|HSPA2|IFNG|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|PYCARD|RELA|TNF|TNFRSF10B,
Ovarian steroidogenesis,KEGG:hsa04913,4.49E-20,6.35E-17,16,50/43037 genes: 0.12%,CGA|CYP11A1|CYP17A1|CYP19A1|CYP1A1|CYP1B1|FSHB|FSHR|HSD17B1|IGF1|IGF1R|INS|LDLR|LHB|PTGS2|STAR,
Signalling to ERKs,REACT:R-HSA-187687,4.72E-20,6.67E-17,28,263/43037 genes: 0.61%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|NTRK1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
AMPK signaling pathway,KEGG:hsa04152,6.60E-20,9.32E-17,21,120/43037 genes: 0.28%,ACACA|ADIPOQ|CCND1|CD36|CPT1A|CREB1|FASN|FBP1|FOXO3|IGF1|IGF1R|INS|IRS2|LEP|PCK1|PPARG|PPARGC1A|RPS6KB2|SLC2A4|SREBF1|TSC2,
IRS-mediated signalling,REACT:R-HSA-112399,8.44E-20,1.19E-16,29,294/43037 genes: 0.68%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
GRB2 events in EGFR signaling,REACT:R-HSA-179812,8.98E-20,1.27E-16,27,245/43037 genes: 0.57%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
RAF/MAP kinase cascade,REACT:R-HSA-5673001,8.98E-20,1.27E-16,27,245/43037 genes: 0.57%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
SHC1 events in EGFR signaling,REACT:R-HSA-180336,8.98E-20,1.27E-16,27,245/43037 genes: 0.57%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
SOS-mediated signalling,REACT:R-HSA-112412,8.98E-20,1.27E-16,27,245/43037 genes: 0.57%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Signaling by Insulin receptor,REACT:R-HSA-74752,9.84E-20,1.39E-16,30,322/43037 genes: 0.75%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|INS|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TLR9|TSC2,
"Interleukin-3, 5 and GM-CSF signaling",REACT:R-HSA-512988,1.06E-19,1.50E-16,28,271/43037 genes: 0.63%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|STAT5B|SYNGAP1,
Th17 cell differentiation,KEGG:hsa04659,1.28E-19,1.81E-16,20,107/43037 genes: 0.25%,AHR|CD4|FOS|IFNG|IL1B|IL4|IL6|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RUNX1|RXRA|RXRB|STAT3|STAT5B|TGFB1,
Gastrin-CREB signalling pathway via PKC and MAPK,REACT:R-HSA-881907,1.54E-19,2.18E-16,34,443/43037 genes: 1.03%,AGT|APP|AVP|CAMK2B|CAMK2G|CREB1|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GNRH1|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|OXT|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1|TRHR,
Interleukin receptor SHC signaling,REACT:R-HSA-912526,2.56E-19,3.61E-16,27,255/43037 genes: 0.59%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
VEGFR2 mediated cell proliferation,REACT:R-HSA-5218921,3.47E-19,4.90E-16,27,258/43037 genes: 0.60%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Neutrophil degranulation,REACT:R-HSA-6798695,3.86E-19,5.45E-16,35,488/43037 genes: 1.13%,AMPD3|APAF1|APRT|ARG1|ATP8B4|CAPN1|CAT|CD36|CD44|CREG1|CSTB|CTSD|CYBA|DNAJC5|EPX|FTL|GSN|HSPA1B|IGF2R|ITGAL|LRRC7|MAPK1|MMP8|MMP9|MPO|NFKB1|ORM1|PRDX6|PYCARD|RETN|SLPI|STBD1|TNFRSF1B|TTR|VNN1,
Prolactin signaling pathway,KEGG:hsa04917,5.98E-19,8.45E-16,17,70/43037 genes: 0.16%,CCND1|CGA|CYP17A1|ESR1|ESR2|FOS|FOXO3|GSK3B|INS|LHB|MAPK1|MAPK3|NFKB1|PRL|RELA|STAT3|STAT5B,
AGE-RAGE signaling pathway in diabetic complications,KEGG:hsa04933,6.19E-19,8.75E-16,19,99/43037 genes: 0.23%,BAX|BCL2|CASP3|CCND1|CXCL8|FN1|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NOS3|NOX1|RELA|STAT3|STAT5B|TGFB1|TNF,
Oxytocin signaling pathway,KEGG:hsa04921,6.23E-19,8.80E-16,22,152/43037 genes: 0.35%,ACTB|ACTG1|CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CAMK2B|CAMK2G|CCND1|CD38|EGFR|FOS|JUN|MAPK1|MAPK3|NOS3|OXT|PTGS2,
Steroid hormone biosynthesis,KEGG:hsa00140,6.77E-19,9.56E-16,16,58/43037 genes: 0.13%,AKR1C4|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP1A1|CYP1B1|CYP21A2|CYP3A4|CYP7A1|HSD17B1|SRD5A2|STS|UGT2A3|UGT2B17,
cAMP signaling pathway,KEGG:hsa04024,1.09E-18,1.54E-15,24,198/43037 genes: 0.46%,ACOX1|BDNF|CACNA1C|CACNA1D|CAMK2B|CAMK2G|CREB1|CREBBP|FOS|FSHB|FSHR|GLI1|GRIA2|GRIA4|GRIN1|GRIN2B|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|PTCH1|RELA|RRAS,
RET signaling,REACT:R-HSA-8853659,1.13E-18,1.59E-15,27,270/43037 genes: 0.63%,CAMK2B|CAMK2G|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FYN|GDNF|GFRA1|GFRA4|GRIN1|GRIN2B|IRS2|KIT|MAPK1|MAPK3|NF1|NRG1|PDGFRA|PDGFRB|RET|SPTBN2|SYNGAP1,
Colorectal cancer,KEGG:hsa05210,1.24E-18,1.76E-15,16,60/43037 genes: 0.14%,BAX|BCL2|CASP3|CASP9|CCND1|CTNNB1|CYCS|DCC|FOS|GSK3B|JUN|MAPK1|MAPK3|MYC|TGFB1|TP53,
Transcriptional regulation of white adipocyte differentiation,REACT:R-HSA-381340,1.55E-18,2.19E-15,18,88/43037 genes: 0.20%,ADIPOQ|CD36|CEBPA|CEBPB|CREBBP|FABP4|LEP|MED1|NFKB1|PCK1|PPARG|PPARGC1A|RELA|RXRA|SLC2A4|SREBF1|TGFB1|TNF,
Viral carcinogenesis,KEGG:hsa05203,1.55E-18,2.20E-15,24,201/43037 genes: 0.47%,ACTN1|BAK1|BAX|CASP3|CASP8|CCND1|CREB1|CREBBP|DLG1|DNAJA3|GSN|HDAC1|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|PMAIP1|REL|RELA|STAT3|STAT5B|TP53|YWHAG,
Metabolism of steroid hormones,REACT:R-HSA-196071,3.66E-18,5.17E-15,13,32/43037 genes: 0.07%,AKR1B1|CGA|CYP11A1|CYP11B1|CYP11B2|CYP17A1|CYP19A1|CYP21A2|HSD17B1|LHB|POMC|SRD5A2|STAR,
Osteoclast differentiation,KEGG:hsa04380,6.15E-18,8.69E-15,20,129/43037 genes: 0.30%,CREB1|CYBA|FOS|FYN|IFNG|IL1B|JUN|MAPK1|MAPK3|NCF1|NCF2|NCF4|NFKB1|NFKBIA|NOX1|PPARG|RELA|TGFB1|TNF|TNFRSF11B,
Apoptosis,REACT:R-HSA-109581,9.50E-18,1.34E-14,22,172/43037 genes: 0.40%,APAF1|BAK1|BAX|BCL2|BCL2L1|BCL2L11|BID|CASP3|CASP8|CASP9|CTNNB1|CYCS|DCC|FAS|FASLG|GSN|PMAIP1|TNFRSF10B|TP53|UNC5B|VIM|YWHAG,
Legionellosis,KEGG:hsa05134,1.03E-17,1.46E-14,15,55/43037 genes: 0.13%,APAF1|CASP3|CASP8|CASP9|CXCL8|CYCS|HSPA1B|HSPA2|IL1B|IL6|NFKB1|NFKBIA|PYCARD|RELA|TNF,
Intrinsic Pathway for Apoptosis,REACT:R-HSA-109606,1.09E-17,1.55E-14,14,44/43037 genes: 0.10%,APAF1|BAK1|BAX|BCL2|BCL2L1|BCL2L11|BID|CASP3|CASP8|CASP9|CYCS|PMAIP1|TP53|YWHAG,
Programmed Cell Death,REACT:R-HSA-5357801,1.39E-17,1.96E-14,22,175/43037 genes: 0.41%,APAF1|BAK1|BAX|BCL2|BCL2L1|BCL2L11|BID|CASP3|CASP8|CASP9|CTNNB1|CYCS|DCC|FAS|FASLG|GSN|PMAIP1|TNFRSF10B|TP53|UNC5B|VIM|YWHAG,
Transcriptional misregulation in cancer,KEGG:hsa05202,2.27E-17,3.20E-14,22,179/43037 genes: 0.42%,BCL2L1|CD86|CEBPA|CEBPB|CXCL8|DDIT3|HDAC1|IGF1|IGF1R|IL6|MMP9|MPO|MYC|NFKB1|NTRK1|PPARG|REL|RELA|RUNX1|RXRA|RXRB|TP53,
Neurotrophin signaling pathway,KEGG:hsa04722,2.35E-17,3.32E-14,19,119/43037 genes: 0.28%,BAX|BCL2|BDNF|CAMK2B|CAMK2G|FASLG|FOXO3|GSK3B|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NTRK1|NTRK2|RELA|RIPK2|TP53,
Bile secretion,KEGG:hsa04976,2.40E-17,3.39E-14,16,71/43037 genes: 0.16%,ABCB1|ABCB11|ABCC2|ABCC3|ABCG2|ABCG8|CA2|CYP3A4|CYP7A1|LDLR|NR1H4|RXRA|SLC10A2|SLC22A7|SLC51A|SLC51B,
Chagas disease (American trypanosomiasis),KEGG:hsa05142,2.55E-17,3.60E-14,18,102/43037 genes: 0.24%,CASP8|CXCL8|FAS|FASLG|FOS|IFNG|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NOS2|RELA|TGFB1|TLR9|TNF,
Ras signaling pathway,KEGG:hsa04014,2.67E-17,3.77E-14,24,227/43037 genes: 0.53%,BCL2L1|EGF|EGFR|FASLG|FGFR4|FOXO4|GRIN1|GRIN2B|IGF1|IGF1R|INS|KIT|MAPK1|MAPK3|NF1|NFKB1|PDGFRA|PDGFRB|PLA2G12A|PLA2G1B|REL|RELA|RRAS|SYNGAP1,
HTLV-I infection,KEGG:hsa05166,3.86E-17,5.46E-14,25,256/43037 genes: 0.59%,ATF3|BAX|BCL2L1|CCND1|CREB1|CREBBP|CREM|CTNNB1|DLG1|FOS|GSK3B|IL6|ITGAL|JUN|MYC|NFKB1|NFKBIA|PDGFRA|PDGFRB|RELA|RRAS|STAT5B|TGFB1|TNF|TP53,
Insulin resistance,KEGG:hsa04931,6.22E-17,8.79E-14,18,107/43037 genes: 0.25%,CD36|CPT1A|CREB1|GSK3B|IL6|INS|IRS2|NFKB1|NFKBIA|NOS3|PCK1|PPARGC1A|RELA|RPS6KB2|SLC2A4|SREBF1|STAT3|TNF,
TNF signaling pathway,KEGG:hsa04668,7.40E-17,1.05E-13,18,108/43037 genes: 0.25%,CASP3|CASP8|CEBPB|CREB1|FAS|FOS|IL1B|IL6|JUN|MAPK1|MAPK3|MMP9|NFKB1|NFKBIA|PTGS2|RELA|TNF|TNFRSF1B,
NOD-like receptor signaling pathway,KEGG:hsa04621,1.09E-16,1.55E-13,21,170/43037 genes: 0.40%,BCL2|BCL2L1|CARD6|CASP12|CASP4|CASP8|CXCL8|CYBA|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NOX1|PYCARD|RELA|RIPK2|TNF,
Gene Expression,REACT:R-HSA-74160,2.39E-16,3.38E-13,62,1831/43037 genes: 4.25%,ACTB|APAF1|APOE|AR|BAX|BID|BRCA1|BTG2|CGA|CREBBP|CSNK2A1|CTDP1|CYCS|DNMT1|DNMT3A|EGFR|ERBB2|ESR1|ESR2|FAS|FOS|GLS|GPX2|GSK3B|GSR|HDAC1|HNRNPH1|HSPB1|HUS1|JUN|KIT|MAPK3|MED1|MYC|NOTCH2|NOTCH3|NOTCH4|NR1H4|NR1I2|NR1I3|NR3C1|NR3C2|NR4A1|NR4A2|NR5A1|PARP1|PGR|PLK3|PMAIP1|PPARG|PRDX1|PRDX2|RPL17|RXRA|RXRB|TFAM|THRA|THRB|TNFRSF10B|TP53|TSC2|YWHAG,
Epstein-Barr virus infection,KEGG:hsa05169,2.47E-16,3.49E-13,22,200/43037 genes: 0.46%,BCL2|CD38|CD44|CREBBP|CSNK2A1|GSK3B|HDAC1|HSPA1B|HSPA2|HSPB1|IFNG|ITGAL|JUN|MYC|NFKB1|NFKBIA|NFKBIB|RELA|STAT3|TP53|VIM|YWHAG,
Glutathione metabolism,KEGG:hsa00480,2.81E-16,3.97E-13,14,54/43037 genes: 0.13%,GCLC|GPX1|GPX2|GPX4|GPX5|GPX6|GSR|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3,
Apoptosis - multiple species,KEGG:hsa04215,3.66E-16,5.17E-13,12,33/43037 genes: 0.08%,APAF1|BAK1|BAX|BCL2|BCL2L1|BCL2L11|BID|CASP3|CASP8|CASP9|CYCS|PMAIP1,
Small cell lung cancer,KEGG:hsa05222,4.23E-16,5.98E-13,16,84/43037 genes: 0.20%,APAF1|BCL2|BCL2L1|CASP9|CCND1|CYCS|FN1|MYC|NFKB1|NFKBIA|NOS2|PTGS2|RELA|RXRA|RXRB|TP53,
p53 signaling pathway,KEGG:hsa04115,4.30E-16,6.08E-13,15,69/43037 genes: 0.16%,APAF1|BAX|BID|CASP3|CASP8|CASP9|CCND1|CYCS|FAS|GADD45B|IGF1|PMAIP1|TNFRSF10B|TP53|TSC2,
Salmonella infection,KEGG:hsa05132,6.29E-16,8.88E-13,16,86/43037 genes: 0.20%,ACTB|ACTG1|CXCL8|FOS|IFNG|IL1B|IL6|JUN|KLC1|MAPK1|MAPK3|NFKB1|NOS2|PFN1|PYCARD|RELA,
"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",REACT:R-HSA-6811558,7.63E-16,1.08E-12,16,87/43037 genes: 0.20%,CD86|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FYN|INS|IRS2|KIT|MAPK1|MAPK3|NRG1|PDGFRA|PDGFRB,
Non-small cell lung cancer,KEGG:hsa05223,8.47E-16,1.20E-12,14,58/43037 genes: 0.13%,ALK|CASP9|CCND1|EGF|EGFR|ERBB2|FOXO3|MAPK1|MAPK3|RXRA|RXRB|STAT3|STAT5B|TP53,
PPAR signaling pathway,KEGG:hsa03320,8.52E-16,1.20E-12,15,72/43037 genes: 0.17%,ACADM|ACOX1|ADIPOQ|CD36|CPT1A|CYP27A1|CYP7A1|CYP8B1|FABP3|FABP4|ME1|PCK1|PPARG|RXRA|RXRB,
Type II diabetes mellitus,KEGG:hsa04930,9.41E-16,1.33E-12,13,46/43037 genes: 0.11%,ADIPOQ|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1G|INS|IRS2|MAPK1|MAPK3|PKLR|SLC2A4|TNF,
Longevity regulating pathway,KEGG:hsa04211,1.12E-15,1.58E-12,16,89/43037 genes: 0.21%,ADIPOQ|BAX|CAT|CREB1|FOXO3|IGF1|IGF1R|INS|IRS2|NFKB1|PPARG|PPARGC1A|RELA|RPS6KB2|TP53|TSC2,
Cytokine-cytokine receptor interaction,KEGG:hsa04060,1.41E-15,1.99E-12,24,270/43037 genes: 0.63%,CD40LG|CXCL8|EGF|EGFR|EPO|FAS|FASLG|GH1|IFNG|IL12RB2|IL1B|IL4|IL6|INHBB|KIT|LEP|PDGFRA|PDGFRB|PRL|TGFB1|TNF|TNFRSF10B|TNFRSF11B|TNFRSF1B,
Th1 and Th2 cell differentiation,KEGG:hsa04658,1.94E-15,2.74E-12,16,92/43037 genes: 0.21%,CD4|FOS|IFNG|IL12RB2|IL4|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|NOTCH2|NOTCH3|RELA|RUNX3|STAT5B,
Pertussis,KEGG:hsa05133,2.02E-15,2.85E-12,15,76/43037 genes: 0.18%,C1R|CASP3|CFL1|CXCL8|FOS|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NOS2|PYCARD|RELA|TNF,
Focal adhesion,KEGG:hsa04510,2.76E-15,3.90E-12,21,199/43037 genes: 0.46%,ACTB|ACTG1|ACTN1|BCL2|CCND1|CTNNB1|EGF|EGFR|ERBB2|FN1|FYN|GSK3B|IGF1|IGF1R|JUN|MAPK1|MAPK3|PDGFRA|PDGFRB|RELN|VASP,
Negative regulation of the PI3K/AKT network,REACT:R-HSA-199418,2.77E-15,3.91E-12,16,94/43037 genes: 0.22%,CD86|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FYN|INS|IRS2|KIT|MAPK1|MAPK3|NRG1|PDGFRA|PDGFRB,
"Fatty acid, triacylglycerol, and ketone body metabolism",REACT:R-HSA-535734,3.12E-15,4.41E-12,23,252/43037 genes: 0.59%,ACACA|ACADM|ACADS|ACOX1|AGT|AHR|CD36|CLOCK|CPT1A|CREBBP|CYP1A1|CYP7A1|ELOVL2|ELOVL3|FASN|ME1|MED1|NR1H4|OXCT1|PPARG|PPARGC1A|RXRA|SREBF1,
Thyroid cancer,KEGG:hsa05216,3.65E-15,5.15E-12,11,29/43037 genes: 0.07%,CCND1|CTNNB1|MAPK1|MAPK3|MYC|NTRK1|PPARG|RET|RXRA|RXRB|TP53,
Calcium signaling pathway,KEGG:hsa04020,5.23E-15,7.40E-12,20,181/43037 genes: 0.42%,CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1G|CACNA1I|CAMK2B|CAMK2G|CD38|EGFR|ERBB2|ERBB3|ERBB4|GRIN1|NOS2|NOS3|PDGFRA|PDGFRB|TNNC2|TRHR,
Herpes simplex infection,KEGG:hsa05168,8.00E-15,1.13E-11,20,185/43037 genes: 0.43%,CASP3|CASP8|CLOCK|CREBBP|CSNK2A1|CYCS|FAS|FASLG|FOS|IFNG|IL1B|IL6|JUN|NFKB1|NFKBIA|NFKBIB|RELA|TLR9|TNF|TP53,
Rap1 signaling pathway,KEGG:hsa04015,8.18E-15,1.16E-11,21,210/43037 genes: 0.49%,ACTB|ACTG1|CTNNB1|EGF|EGFR|FGFR4|GRIN1|GRIN2B|IGF1|IGF1R|INS|ITGAL|KIT|MAGI2|MAPK1|MAPK3|PDGFRA|PDGFRB|PFN1|RRAS|VASP,
Amphetamine addiction,KEGG:hsa05031,9.37E-15,1.32E-11,14,68/43037 genes: 0.16%,CACNA1C|CACNA1D|CAMK2B|CAMK2G|CREB1|DDC|FOS|GRIA2|GRIA4|GRIN1|GRIN2B|HDAC1|JUN|SLC6A3,
T cell receptor signaling pathway,KEGG:hsa04660,1.24E-14,1.76E-11,16,103/43037 genes: 0.24%,CD4|CD40LG|DLG1|FOS|FYN|GSK3B|IFNG|IL4|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|TNF,
ErbB signaling pathway,KEGG:hsa04012,1.41E-14,1.99E-11,15,86/43037 genes: 0.20%,CAMK2B|CAMK2G|EGF|EGFR|ERBB2|ERBB3|ERBB4|GSK3B|JUN|MAPK1|MAPK3|MYC|NRG1|RPS6KB2|STAT5B,
PPARA activates gene expression,REACT:R-HSA-1989781,1.58E-14,2.23E-11,17,124/43037 genes: 0.29%,ACADM|ACOX1|AGT|AHR|CD36|CLOCK|CPT1A|CREBBP|CYP1A1|CYP7A1|ME1|MED1|NR1H4|PPARG|PPARGC1A|RXRA|SREBF1,
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha),REACT:R-HSA-400206,2.37E-14,3.34E-11,17,127/43037 genes: 0.30%,ACADM|ACOX1|AGT|AHR|CD36|CLOCK|CPT1A|CREBBP|CYP1A1|CYP7A1|ME1|MED1|NR1H4|PPARG|PPARGC1A|RXRA|SREBF1,
Glutamatergic synapse,KEGG:hsa04724,6.45E-14,9.11E-11,16,114/43037 genes: 0.26%,CACNA1A|CACNA1C|CACNA1D|DLG4|GLS|GRIA2|GRIA4|GRIK1|GRIK2|GRIN1|GRIN2B|MAPK1|MAPK3|SHANK2|SLC1A2|SLC1A6,
Pancreatic cancer,KEGG:hsa05212,1.03E-13,1.45E-10,13,64/43037 genes: 0.15%,BCL2L1|CASP9|CCND1|EGF|EGFR|ERBB2|MAPK1|MAPK3|NFKB1|RELA|STAT3|TGFB1|TP53,
Endometrial cancer,KEGG:hsa05213,1.07E-13,1.51E-10,12,50/43037 genes: 0.12%,CASP9|CCND1|CTNNB1|EGF|EGFR|ERBB2|FOXO3|GSK3B|MAPK1|MAPK3|MYC|TP53,
Constitutive Signaling by Aberrant PI3K in Cancer,REACT:R-HSA-2219530,1.27E-13,1.80E-10,13,65/43037 genes: 0.15%,CD86|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FYN|IRS2|KIT|NRG1|PDGFRA|PDGFRB,
Shigellosis,KEGG:hsa05131,1.27E-13,1.80E-10,13,65/43037 genes: 0.15%,ACTB|ACTG1|CD44|CTTN|CXCL8|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|PFN1|RELA|RIPK2,
Aldosterone synthesis and secretion,KEGG:hsa04925,1.47E-13,2.07E-10,14,82/43037 genes: 0.19%,CACNA1C|CACNA1D|CACNA1G|CACNA1I|CAMK2B|CAMK2G|CREB1|CYP11A1|CYP11B2|CYP21A2|LDLR|NR4A1|NR4A2|STAR,
Hypertrophic cardiomyopathy (HCM),KEGG:hsa05410,1.75E-13,2.47E-10,14,83/43037 genes: 0.19%,ACTB|ACTG1|CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|IGF1|IL6|TGFB1|TNF,
Transcriptional Regulation by TP53,REACT:R-HSA-3700989,1.93E-13,2.72E-10,25,370/43037 genes: 0.86%,APAF1|BAX|BID|BRCA1|BTG2|CREBBP|CSNK2A1|CTDP1|CYCS|FAS|FOS|GLS|GPX2|GSR|HDAC1|HUS1|JUN|PLK3|PMAIP1|PRDX1|PRDX2|TNFRSF10B|TP53|TSC2|YWHAG,
Huntington's disease,KEGG:hsa05016,2.09E-13,2.95E-10,19,193/43037 genes: 0.45%,APAF1|BAX|BDNF|CASP3|CASP8|CASP9|CREB1|CREBBP|CYCS|DLG4|GPX1|GRIN1|GRIN2B|HDAC1|PPARG|PPARGC1A|SOD1|TFAM|TP53,
Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell,REACT:R-HSA-112314,2.46E-13,3.48E-10,17,146/43037 genes: 0.34%,CACNG2|CAMK2B|CAMK2G|CREB1|DLG1|DLG4|GABRA4|GABRB1|GRIA2|GRIA4|GRIK1|GRIK2|GRIN1|GRIN2B|GRIP1|MAPK1|RRAS,
Hemostasis,REACT:R-HSA-109582,3.05E-13,4.31E-10,32,639/43037 genes: 1.48%,ACTN1|ALB|APOB|APP|CD36|CD44|CFL1|CLU|CREBBP|DOCK10|EGF|FN1|FYN|HBG1|HDAC1|IGF1|IGF2|ITGAL|KLC1|MAPK1|MAPK3|MERTK|MMRN1|NOS2|NOS3|ORM1|PFN1|SOD1|TF|TGFB1|TNFRSF10B|TP53,
Acute myeloid leukemia,KEGG:hsa05221,3.69E-13,5.21E-10,12,55/43037 genes: 0.13%,CCND1|CEBPA|KIT|MAPK1|MAPK3|MYC|NFKB1|RELA|RPS6KB2|RUNX1|STAT3|STAT5B,
Chronic myeloid leukemia,KEGG:hsa05220,4.25E-13,6.01E-10,13,71/43037 genes: 0.16%,BCL2L1|CCND1|HDAC1|MAPK1|MAPK3|MYC|NFKB1|NFKBIA|RELA|RUNX1|STAT5B|TGFB1|TP53,
Circadian Clock,REACT:R-HSA-400253,4.25E-13,6.01E-10,13,71/43037 genes: 0.16%,AVP|BHLHE40|CLOCK|CPT1A|CREB1|CREBBP|CREM|DBP|MED1|NR3C1|PPARGC1A|RXRA|SREBF1,
Arrhythmogenic right ventricular cardiomyopathy (ARVC),KEGG:hsa05412,5.14E-13,7.27E-10,13,72/43037 genes: 0.17%,ACTB|ACTG1|CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CDH2|CTNNB1|GJA1,
Bile acid and bile salt metabolism,REACT:R-HSA-194068,5.33E-13,7.53E-10,11,43/43037 genes: 0.10%,ABCB11|ABCC3|AKR1C4|ALB|CYP27A1|CYP7A1|CYP8B1|HSD17B4|NR1H4|RXRA|SLC10A2,
Hepatitis C,KEGG:hsa05160,5.90E-13,8.34E-10,16,131/43037 genes: 0.30%,CD81|CLDN7|CXCL8|EGF|EGFR|GSK3B|LDLR|MAPK1|MAPK3|NFKB1|NFKBIA|RELA|RXRA|STAT3|TNF|TP53,
Metabolism of xenobiotics by cytochrome P450,KEGG:hsa00980,6.20E-13,8.76E-10,13,73/43037 genes: 0.17%,CYP1A1|CYP1B1|CYP2B6|CYP3A4|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3|UGT2A3|UGT2B17,
Metabolism of proteins,REACT:R-HSA-392499,6.51E-13,9.20E-10,52,1623/43037 genes: 3.77%,ACTB|AGT|ALPL|APP|AR|ARFGEF2|ATF3|ATF6|BACE1|BRCA1|CGA|CPB1|CSNK2A1|CTNNB1|CTSD|CXCL8|DDIT3|ESR1|FOXO4|FSHB|GH1|GSN|IGF1|IGF2|IGFBP2|INHBB|INS|KLK3|LEP|LHB|MDGA2|MYC|NFKBIA|PARP1|PDIA6|POMC|PRKN|PRL|RENBP|RIPK2|RPL17|SPTBN2|STAT3|STS|SUMO2|TGFB1|TGFBI|TIMM13|TP53|TSHB|TTR|VNN1,
Peptide hormone metabolism,REACT:R-HSA-2980736,6.55E-13,9.25E-10,14,91/43037 genes: 0.21%,AGT|CGA|CPB1|CTNNB1|CTSD|FSHB|GH1|IGF1|INHBB|INS|LEP|LHB|POMC|TSHB,
Platelet degranulation,REACT:R-HSA-114608,6.65E-13,9.40E-10,16,132/43037 genes: 0.31%,ACTN1|ALB|APP|CD36|CFL1|CLU|EGF|FN1|IGF1|IGF2|MMRN1|ORM1|PFN1|SOD1|TF|TGFB1,
Viral myocarditis,KEGG:hsa05416,7.28E-13,1.03E-09,12,58/43037 genes: 0.13%,ACTB|ACTG1|BID|CASP3|CASP8|CASP9|CCND1|CD40LG|CD86|CYCS|FYN|ITGAL,
NF-kappa B signaling pathway,KEGG:hsa04064,1.04E-12,1.47E-09,14,94/43037 genes: 0.22%,BCL2|BCL2L1|CARD10|CD40LG|CSNK2A1|CXCL8|GADD45B|IL1B|NFKB1|NFKBIA|PARP1|PTGS2|RELA|TNF,
Response to elevated platelet cytosolic Ca2+,REACT:R-HSA-76005,1.19E-12,1.68E-09,16,137/43037 genes: 0.32%,ACTN1|ALB|APP|CD36|CFL1|CLU|EGF|FN1|IGF1|IGF2|MMRN1|ORM1|PFN1|SOD1|TF|TGFB1,
Amoebiasis,KEGG:hsa05146,1.21E-12,1.71E-09,14,95/43037 genes: 0.22%,ACTN1|ARG1|CASP3|CXCL8|FN1|HSPB1|IFNG|IL1B|IL6|NFKB1|NOS2|RELA|TGFB1|TNF,
Insulin signaling pathway,KEGG:hsa04910,1.34E-12,1.89E-09,16,138/43037 genes: 0.32%,ACACA|FASN|FBP1|GSK3B|INS|IRS2|MAPK1|MAPK3|MKNK2|PCK1|PKLR|PPARGC1A|RPS6KB2|SLC2A4|SREBF1|TSC2,
Circadian entrainment,KEGG:hsa04713,1.40E-12,1.98E-09,14,96/43037 genes: 0.22%,CACNA1C|CACNA1D|CACNA1G|CACNA1I|CAMK2B|CAMK2G|CREB1|FOS|GRIA2|GRIA4|GRIN1|GRIN2B|MAPK1|MAPK3,
Phase 0 - rapid depolarisation,REACT:R-HSA-5576892,1.55E-12,2.20E-09,11,47/43037 genes: 0.11%,CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CAMK2B|CAMK2G|SCN5A,
"BMAL1:CLOCK,NPAS2 activates circadian gene expression",REACT:R-HSA-1368108,2.00E-12,2.82E-09,11,48/43037 genes: 0.11%,AVP|BHLHE40|CLOCK|CREB1|CREBBP|CREM|DBP|MED1|NR3C1|PPARGC1A|RXRA,
Glioma,KEGG:hsa05214,2.54E-12,3.59E-09,12,64/43037 genes: 0.15%,CAMK2B|CAMK2G|CCND1|EGF|EGFR|IGF1|IGF1R|MAPK1|MAPK3|PDGFRA|PDGFRB|TP53,
Cocaine addiction,KEGG:hsa05030,2.55E-12,3.61E-09,11,49/43037 genes: 0.11%,BDNF|CREB1|DDC|DLG4|GRIA2|GRIN1|GRIN2B|JUN|NFKB1|RELA|SLC6A3,
Malaria,KEGG:hsa05144,2.55E-12,3.61E-09,11,49/43037 genes: 0.11%,CD36|CD40LG|CD81|CXCL8|IFNG|IL1B|IL6|ITGAL|TGFB1|TLR9|TNF,
Adrenergic signaling in cardiomyocytes,KEGG:hsa04261,2.59E-12,3.67E-09,16,144/43037 genes: 0.33%,BCL2|CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CAMK2B|CAMK2G|CREB1|CREM|MAPK1|MAPK3|SCN5A,
Chemical carcinogenesis,KEGG:hsa05204,2.95E-12,4.16E-09,13,82/43037 genes: 0.19%,CYP1A1|CYP1B1|CYP3A4|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3|PTGS2|UGT2A3|UGT2B17,
Central carbon metabolism in cancer,KEGG:hsa05230,3.08E-12,4.36E-09,12,65/43037 genes: 0.15%,EGFR|ERBB2|GLS|KIT|MAPK1|MAPK3|MYC|NTRK1|PDGFRA|PDGFRB|RET|TP53,
Toll-like receptor signaling pathway,KEGG:hsa04620,4.32E-12,6.10E-09,14,104/43037 genes: 0.24%,CASP8|CD86|CXCL8|FOS|IL1B|IL6|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|RELA|TLR9|TNF,
Signaling by GPCR,REACT:R-HSA-372790,5.71E-12,8.07E-09,45,1341/43037 genes: 3.12%,ADM|AGT|APP|AVP|CAMK2B|CAMK2G|CGA|CREB1|CXCL8|DLG4|EGF|EGFR|ERBB2|ERBB3|ERBB4|FGFR4|FN1|FSHB|FSHR|FYN|GDNF|GFRA1|GFRA4|GNRH1|GRIN1|GRIN2B|IRS2|KIT|LHB|MAPK1|MAPK3|NF1|NRG1|OXT|PDGFRA|PDGFRB|POMC|PTCH1|PTCH2|REEP6|RET|SPTBN2|SYNGAP1|TRHR|TSHB,
Dopaminergic synapse,KEGG:hsa04728,7.24E-12,1.02E-08,15,130/43037 genes: 0.30%,CACNA1A|CACNA1B|CACNA1C|CACNA1D|CAMK2B|CAMK2G|CLOCK|CREB1|DDC|FOS|GRIA2|GRIA4|GRIN2B|GSK3B|SLC6A3,
Dilated cardiomyopathy,KEGG:hsa05414,8.70E-12,1.23E-08,13,89/43037 genes: 0.21%,ACTB|ACTG1|CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|IGF1|TGFB1|TNF,
Activation of NMDA receptor upon glutamate binding and postsynaptic events,REACT:R-HSA-442755,1.04E-11,1.47E-08,10,41/43037 genes: 0.10%,CAMK2B|CAMK2G|CREB1|DLG4|GRIA2|GRIA4|GRIN1|GRIN2B|MAPK1|RRAS,
Bladder cancer,KEGG:hsa05219,1.04E-11,1.47E-08,10,41/43037 genes: 0.10%,CCND1|CXCL8|EGF|EGFR|ERBB2|MAPK1|MAPK3|MMP9|MYC|TP53,
Adherens junction,KEGG:hsa04520,1.10E-11,1.56E-08,12,72/43037 genes: 0.17%,ACTB|ACTG1|ACTN1|CREBBP|CSNK2A1|CTNNB1|EGFR|ERBB2|FYN|IGF1R|MAPK1|MAPK3,
Protein-protein interactions at synapses,REACT:R-HSA-6794362,1.10E-11,1.56E-08,12,72/43037 genes: 0.17%,DLG1|DLG4|DLGAP3|DLGAP4|GRIA4|GRIN1|GRIN2B|NLGN1|NRXN1|NRXN2|SHANK2|STXBP1,
Regulation of actin cytoskeleton,KEGG:hsa04810,1.11E-11,1.57E-08,18,212/43037 genes: 0.49%,ACTB|ACTG1|ACTN1|CFL1|EGF|EGFR|FGFR4|FN1|GSN|INS|ITGAL|MAPK1|MAPK3|PDGFRA|PDGFRB|PFN1|RDX|RRAS,
Thyroid hormone synthesis,KEGG:hsa04918,1.54E-11,2.18E-08,12,74/43037 genes: 0.17%,ALB|CGA|CREB1|GPX1|GPX2|GPX5|GPX6|GSR|TG|TPO|TSHB|TTR,
Neuroactive ligand-receptor interaction,KEGG:hsa04080,1.55E-11,2.19E-08,20,277/43037 genes: 0.64%,CGA|FSHB|FSHR|GABRA4|GABRB1|GH1|GRIA2|GRIA4|GRIK1|GRIK2|GRIN1|GRIN2B|LEP|LHB|NR3C1|PRL|THRA|THRB|TRHR|TSHB,
Antifolate resistance,KEGG:hsa01523,2.01E-11,2.85E-08,9,31/43037 genes: 0.07%,ABCC2|ABCC3|ABCG2|IL1B|IL6|NFKB1|RELA|SHMT2|TNF,
Tight junction,KEGG:hsa04530,3.32E-11,4.69E-08,16,170/43037 genes: 0.40%,ACTB|ACTG1|ACTN1|CACNA1D|CCND1|CLDN7|CTTN|DLG1|ERBB2|JUN|MYH1|MYH8|RDX|RUNX1|SLC9A3R1|VASP,
Longevity regulating pathway - multiple species,KEGG:hsa04213,3.95E-11,5.58E-08,11,62/43037 genes: 0.14%,CAT|FOXO3|HDAC1|HSPA1B|HSPA2|IGF1|IGF1R|INS|IRS2|RPS6KB2|SOD1,
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,REACT:R-HSA-8862803,5.16E-11,7.29E-08,8,23/43037 genes: 0.05%,APP|BCL2L11|CAPN1|FASLG|FOXO3|JUN|PRDX1|PRDX2,
Neurodegenerative Diseases,REACT:R-HSA-8863678,5.16E-11,7.29E-08,8,23/43037 genes: 0.05%,APP|BCL2L11|CAPN1|FASLG|FOXO3|JUN|PRDX1|PRDX2,
Inflammatory bowel disease (IBD),KEGG:hsa05321,6.76E-11,9.55E-08,11,65/43037 genes: 0.15%,IFNG|IL12RB2|IL1B|IL4|IL6|JUN|NFKB1|RELA|STAT3|TGFB1|TNF,
Toll-Like Receptors Cascades,REACT:R-HSA-168898,7.66E-11,1.08E-07,15,153/43037 genes: 0.36%,APOB|APP|CASP8|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2|TLR9,
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol,REACT:R-HSA-193368,7.67E-11,1.08E-07,8,24/43037 genes: 0.06%,ABCB11|AKR1C4|CYP27A1|CYP7A1|CYP8B1|HSD17B4|NR1H4|RXRA,
Signaling by PTK6,REACT:R-HSA-8848021,9.53E-11,1.35E-07,11,67/43037 genes: 0.16%,CCND1|EGF|EGFR|ERBB2|ERBB3|ERBB4|NF1|NR3C1|NRG1|STAT3|SYNGAP1,
Jak-STAT signaling pathway,KEGG:hsa04630,1.01E-10,1.43E-07,15,156/43037 genes: 0.36%,BCL2|BCL2L1|CCND1|CREBBP|EPO|GH1|IFNG|IL12RB2|IL4|IL6|LEP|MYC|PRL|STAT3|STAT5B,
Constitutive Signaling by AKT1 E17K in Cancer,REACT:R-HSA-5674400,1.12E-10,1.58E-07,8,25/43037 genes: 0.06%,CASP9|CREB1|FOXO3|FOXO4|GSK3B|NR4A1|RPS6KB2|TSC2,
NCAM1 interactions,REACT:R-HSA-419037,1.18E-10,1.66E-07,9,37/43037 genes: 0.09%,CACNA1C|CACNA1D|CACNA1G|CACNA1I|CACNB1|CACNB3|GDNF|GFRA1|GFRA4,
Drug metabolism - cytochrome P450,KEGG:hsa00982,1.33E-10,1.88E-07,11,69/43037 genes: 0.16%,CYP2B6|CYP3A4|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3|UGT2A3|UGT2B17,
"Platelet activation, signaling and aggregation",REACT:R-HSA-76002,1.63E-10,2.31E-07,19,282/43037 genes: 0.66%,ACTN1|ALB|APP|CD36|CFL1|CLU|EGF|FN1|FYN|IGF1|IGF2|MAPK1|MAPK3|MMRN1|ORM1|PFN1|SOD1|TF|TGFB1,
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,REACT:R-HSA-975138,1.90E-10,2.68E-07,12,91/43037 genes: 0.21%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2|TLR9,
"Unblocking of NMDA receptor, glutamate binding and activation",REACT:R-HSA-438066,2.11E-10,2.98E-07,7,17/43037 genes: 0.04%,CAMK2B|CAMK2G|DLG4|GRIA2|GRIA4|GRIN1|GRIN2B,
Leukocyte transendothelial migration,KEGG:hsa04670,2.12E-10,3.00E-07,13,114/43037 genes: 0.26%,ACTB|ACTG1|ACTN1|CLDN7|CTNNB1|CYBA|ITGAL|MMP9|NCF1|NCF2|NCF4|NOX1|VASP,
GnRH signaling pathway,KEGG:hsa04912,2.16E-10,3.05E-07,12,92/43037 genes: 0.21%,CACNA1C|CACNA1D|CAMK2B|CAMK2G|CGA|EGFR|FSHB|GNRH1|JUN|LHB|MAPK1|MAPK3,
Activated TLR4 signalling,REACT:R-HSA-166054,2.37E-10,3.35E-07,13,115/43037 genes: 0.27%,APP|CASP8|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Protein processing in endoplasmic reticulum,KEGG:hsa04141,2.44E-10,3.45E-07,15,166/43037 genes: 0.39%,ATF6|BAK1|BAX|BCL2|CAPN1|CASP12|DDIT3|DNAJA2|DNAJB2|DNAJC5|HSPA1B|HSPA2|NFE2L2|PDIA6|PRKN,
MyD88 dependent cascade initiated on endosome,REACT:R-HSA-975155,2.46E-10,3.47E-07,12,93/43037 genes: 0.22%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2|TLR9,
Toll Like Receptor 7/8 (TLR7/8) Cascade,REACT:R-HSA-168181,2.46E-10,3.47E-07,12,93/43037 genes: 0.22%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2|TLR9,
Caspase activation via extrinsic apoptotic signalling pathway,REACT:R-HSA-5357769,3.13E-10,4.42E-07,8,28/43037 genes: 0.07%,CASP3|CASP8|CASP9|DCC|FAS|FASLG|TNFRSF10B|UNC5B,
Phase 2 - plateau phase,REACT:R-HSA-5576893,3.13E-10,4.42E-07,8,28/43037 genes: 0.07%,CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7,
MyD88:Mal cascade initiated on plasma membrane,REACT:R-HSA-166058,3.17E-10,4.47E-07,12,95/43037 genes: 0.22%,APP|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor 2 (TLR2) Cascade,REACT:R-HSA-181438,3.17E-10,4.47E-07,12,95/43037 genes: 0.22%,APP|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor TLR1:TLR2 Cascade,REACT:R-HSA-168179,3.17E-10,4.47E-07,12,95/43037 genes: 0.22%,APP|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor TLR6:TLR2 Cascade,REACT:R-HSA-168188,3.17E-10,4.47E-07,12,95/43037 genes: 0.22%,APP|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Extracellular matrix organization,REACT:R-HSA-1474244,3.92E-10,5.54E-07,19,297/43037 genes: 0.69%,ACTN1|CAPN1|CAPN11|CASP3|CD44|COL16A1|CTSD|DMP1|FN1|ITGAL|MMP10|MMP13|MMP17|MMP7|MMP8|MMP9|NRXN1|TGFB1|TTR,
Toll Like Receptor 9 (TLR9) Cascade,REACT:R-HSA-168138,4.05E-10,5.73E-07,12,97/43037 genes: 0.23%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2|TLR9,
Interactions of neurexins and neuroligins at synapses,REACT:R-HSA-6794361,4.14E-10,5.85E-07,10,58/43037 genes: 0.13%,DLG4|DLGAP3|DLGAP4|GRIN1|GRIN2B|NLGN1|NRXN1|NRXN2|SHANK2|STXBP1,
Vesicle-mediated transport,REACT:R-HSA-5653656,4.15E-10,5.87E-07,28,659/43037 genes: 1.53%,ALB|APOB|APOE|APP|AVP|CD36|CD4|CTTN|EGF|EGFR|FTL|GJA1|GJB1|GJB2|IGF2R|INS|KLC1|LDLR|MYH1|MYH8|PACSIN1|RABGAP1|SCARA5|SLC2A4|SPTBN2|TF|TSC2|YWHAG,
CREB phosphorylation through the activation of Ras,REACT:R-HSA-442742,4.28E-10,6.05E-07,8,29/43037 genes: 0.07%,CAMK2B|CAMK2G|CREB1|DLG4|GRIN1|GRIN2B|MAPK1|RRAS,
Estrogen signaling pathway,KEGG:hsa04915,4.58E-10,6.47E-07,12,98/43037 genes: 0.23%,CREB1|EGFR|ESR1|ESR2|FOS|HSPA1B|HSPA2|JUN|MAPK1|MAPK3|MMP9|NOS3,
Axon guidance,KEGG:hsa04360,5.12E-10,7.24E-07,15,175/43037 genes: 0.41%,CAMK2B|CAMK2G|CFL1|DCC|EPHA3|EPHA8|FYN|GSK3B|MAPK1|MAPK3|PTCH1|ROBO1|RRAS|SLIT1|UNC5B,
MyD88-independent TLR3/TLR4 cascade,REACT:R-HSA-166166,5.16E-10,7.29E-07,12,99/43037 genes: 0.23%,APP|CASP8|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor 3 (TLR3) Cascade,REACT:R-HSA-168164,5.16E-10,7.29E-07,12,99/43037 genes: 0.23%,APP|CASP8|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
TRIF-mediated TLR3/TLR4 signaling,REACT:R-HSA-937061,5.16E-10,7.29E-07,12,99/43037 genes: 0.23%,APP|CASP8|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
CLEC7A/inflammasome pathway,REACT:R-HSA-5660668,6.80E-10,9.61E-07,5,6/43037 genes: 0.01%,CASP8|IL1B|NFKB1|PYCARD|RELA,
Toll Like Receptor 4 (TLR4) Cascade,REACT:R-HSA-166016,7.49E-10,1.06E-06,13,126/43037 genes: 0.29%,APP|CASP8|CD36|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
"Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity",REACT:R-HSA-399721,1.02E-09,1.44E-06,8,32/43037 genes: 0.07%,CACNG2|CAMK2B|CAMK2G|DLG1|DLG4|GRIA2|GRIA4|GRIP1,
Trafficking of AMPA receptors,REACT:R-HSA-399719,1.02E-09,1.44E-06,8,32/43037 genes: 0.07%,CACNG2|CAMK2B|CAMK2G|DLG1|DLG4|GRIA2|GRIA4|GRIP1,
MyD88 cascade initiated on plasma membrane,REACT:R-HSA-975871,1.18E-09,1.66E-06,11,84/43037 genes: 0.20%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor 10 (TLR10) Cascade,REACT:R-HSA-168142,1.18E-09,1.66E-06,11,84/43037 genes: 0.20%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Toll Like Receptor 5 (TLR5) Cascade,REACT:R-HSA-168176,1.18E-09,1.66E-06,11,84/43037 genes: 0.20%,APP|CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
Phase II conjugation,REACT:R-HSA-156580,1.28E-09,1.82E-06,12,107/43037 genes: 0.25%,GCLC|GLYAT|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3|TPMT|UGT2A3|UGT2B17,
Synthesis of bile acids and bile salts,REACT:R-HSA-192105,1.73E-09,2.44E-06,8,34/43037 genes: 0.08%,ABCB11|AKR1C4|CYP27A1|CYP7A1|CYP8B1|HSD17B4|NR1H4|RXRA,
Interleukin-10 signaling,REACT:R-HSA-6783783,1.74E-09,2.46E-06,9,49/43037 genes: 0.11%,CD86|CXCL8|IL1B|IL4|IL6|PTGS2|STAT3|TNF|TNFRSF1B,
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels,REACT:R-HSA-112308,1.88E-09,2.66E-06,6,13/43037 genes: 0.03%,CACNA1A|CACNA1B|CACNA2D3|CACNB1|CACNB3|CACNG2,
ERBB2 Activates PTK6 Signaling,REACT:R-HSA-8847993,1.88E-09,2.66E-06,6,13/43037 genes: 0.03%,EGF|EGFR|ERBB2|ERBB3|ERBB4|NRG1,
Hormone ligand-binding receptors,REACT:R-HSA-375281,1.88E-09,2.66E-06,6,13/43037 genes: 0.03%,CGA|FSHB|FSHR|GNRH1|LHB|TSHB,
Cholinergic synapse,KEGG:hsa04725,2.19E-09,3.09E-06,12,112/43037 genes: 0.26%,BCL2|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CAMK2B|CAMK2G|CREB1|FOS|FYN|MAPK1|MAPK3,
Degradation of the extracellular matrix,REACT:R-HSA-1474228,2.19E-09,3.09E-06,12,112/43037 genes: 0.26%,CAPN1|CAPN11|CASP3|CD44|COL16A1|CTSD|MMP10|MMP13|MMP17|MMP7|MMP8|MMP9,
Prion diseases,KEGG:hsa05020,2.22E-09,3.14E-06,8,35/43037 genes: 0.08%,BAX|CASP12|FYN|IL1B|IL6|MAPK1|MAPK3|SOD1,
Melanoma,KEGG:hsa05218,2.44E-09,3.45E-06,10,69/43037 genes: 0.16%,CCND1|EGF|EGFR|IGF1|IGF1R|MAPK1|MAPK3|PDGFRA|PDGFRB|TP53,
Carbon metabolism,KEGG:hsa01200,2.68E-09,3.79E-06,12,114/43037 genes: 0.26%,ACADM|ACADS|CAT|FBP1|GAPDH|GPT|ME1|OGDH|PKLR|RGN|SHMT2|SUCLG2,
B cell receptor signaling pathway,KEGG:hsa04662,2.82E-09,3.99E-06,10,70/43037 genes: 0.16%,CD81|FOS|GSK3B|JUN|MAPK1|MAPK3|NFKB1|NFKBIA|NFKBIB|RELA,
Autoimmune thyroid disease,KEGG:hsa05320,3.03E-09,4.29E-06,9,52/43037 genes: 0.12%,CD40LG|CD86|CGA|FAS|FASLG|IL4|TG|TPO|TSHB,
ERBB2 Regulates Cell Motility,REACT:R-HSA-6785631,3.26E-09,4.61E-06,6,14/43037 genes: 0.03%,EGF|EGFR|ERBB2|ERBB3|ERBB4|NRG1,
Peptide hormone biosynthesis,REACT:R-HSA-209952,3.26E-09,4.61E-06,6,14/43037 genes: 0.03%,CGA|FSHB|INHBB|LHB|POMC|TSHB,
Post NMDA receptor activation events,REACT:R-HSA-438064,3.58E-09,5.06E-06,8,37/43037 genes: 0.09%,CAMK2B|CAMK2G|CREB1|DLG4|GRIN1|GRIN2B|MAPK1|RRAS,
Sphingolipid signaling pathway,KEGG:hsa04071,3.99E-09,5.64E-06,12,118/43037 genes: 0.27%,BAX|BCL2|BID|CTSD|FYN|MAPK1|MAPK3|NFKB1|NOS3|RELA|TNF|TP53,
Phospholipase D signaling pathway,KEGG:hsa04072,4.25E-09,6.00E-06,13,145/43037 genes: 0.34%,AVP|CXCL8|EGF|EGFR|FYN|INS|KIT|MAPK1|MAPK3|PDGFRA|PDGFRB|RRAS|TSC2,
Muscle contraction,REACT:R-HSA-397014,4.26E-09,6.02E-06,15,204/43037 genes: 0.47%,CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CAMK2B|CAMK2G|MYH8|SCN5A|TNNC2|TNNT1|VIM,
Metabolism of vitamins and cofactors,REACT:R-HSA-196854,4.41E-09,6.23E-06,14,174/43037 genes: 0.40%,ACACA|AKR1B10|AKR1C4|APOB|APOE|CD38|CYB5A|CYP8B1|FASN|LDLR|PTGS2|SHMT2|TTR|VNN1,
Growth hormone receptor signaling,REACT:R-HSA-982772,4.86E-09,6.87E-06,7,25/43037 genes: 0.06%,GH1|IRS2|MAPK1|MAPK3|PRL|STAT3|STAT5B,
Synthesis of bile acids and bile salts via 27-hydroxycholesterol,REACT:R-HSA-193807,5.39E-09,7.62E-06,6,15/43037 genes: 0.03%,AKR1C4|CYP27A1|CYP7A1|CYP8B1|NR1H4|RXRA,
Glutathione conjugation,REACT:R-HSA-156590,5.60E-09,7.92E-06,8,39/43037 genes: 0.09%,GCLC|GSTM1|GSTM2|GSTM3|GSTM4|GSTT1|GSTT2|MGST3,
Cross-presentation of particulate exogenous antigens (phagosomes),REACT:R-HSA-1236973,6.24E-09,8.81E-06,5,8/43037 genes: 0.02%,CD36|CYBA|NCF1|NCF2|NCF4,
Nicotine addiction,KEGG:hsa05033,6.94E-09,9.81E-06,8,40/43037 genes: 0.09%,CACNA1A|CACNA1B|GABRA4|GABRB1|GRIA2|GRIA4|GRIN1|GRIN2B,
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors,REACT:R-HSA-8864260,6.94E-09,9.81E-06,8,40/43037 genes: 0.09%,APOE|CGA|CREBBP|EGFR|ERBB2|ESR1|KIT|MYC,
PI3K events in ERBB2 signaling,REACT:R-HSA-1963642,8.55E-09,1.21E-05,6,16/43037 genes: 0.04%,EGF|EGFR|ERBB2|ERBB3|ERBB4|NRG1,
Recycling of bile acids and salts,REACT:R-HSA-159418,8.55E-09,1.21E-05,6,16/43037 genes: 0.04%,ABCB11|ABCC3|ALB|NR1H4|RXRA|SLC10A2,
Retrograde endocannabinoid signaling,KEGG:hsa04723,8.61E-09,1.22E-05,11,101/43037 genes: 0.23%,CACNA1A|CACNA1B|CACNA1C|CACNA1D|GABRA4|GABRB1|GRIA2|GRIA4|MAPK1|MAPK3|PTGS2,
Activation of gene expression by SREBF (SREBP),REACT:R-HSA-2426168,1.05E-08,1.48E-05,8,42/43037 genes: 0.10%,ACACA|CREBBP|FASN|IDI1|MED1|RXRA|SQLE|SREBF1,
RORA activates gene expression,REACT:R-HSA-1368082,1.17E-08,1.65E-05,7,28/43037 genes: 0.07%,CLOCK|CPT1A|CREBBP|MED1|PPARGC1A|RXRA|SREBF1,
CREB phosphorylation through the activation of CaMKII,REACT:R-HSA-442729,1.31E-08,1.85E-05,6,17/43037 genes: 0.04%,CAMK2B|CAMK2G|CREB1|DLG4|GRIN1|GRIN2B,
AKT phosphorylates targets in the nucleus,REACT:R-HSA-198693,1.39E-08,1.97E-05,5,9/43037 genes: 0.02%,CREB1|FOXO3|FOXO4|NR4A1|RPS6KB2,
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members,REACT:R-HSA-111453,1.39E-08,1.97E-05,5,9/43037 genes: 0.02%,BCL2|BCL2L1|BCL2L11|BID|PMAIP1,
Glucocorticoid biosynthesis,REACT:R-HSA-194002,1.39E-08,1.97E-05,5,9/43037 genes: 0.02%,CYP11B1|CYP11B2|CYP17A1|CYP21A2|POMC,
RHO GTPase Effectors,REACT:R-HSA-195258,1.48E-08,2.10E-05,17,294/43037 genes: 0.68%,ACTB|ACTG1|AR|CTNNB1|CTTN|CYBA|DLG4|KLC1|KLK3|MAPK1|MAPK3|NCF1|NCF2|NCF4|NOX1|PFN1|YWHAG,
Arachidonic acid metabolism,KEGG:hsa00590,1.53E-08,2.16E-05,9,62/43037 genes: 0.14%,CYP2B6|EPHX2|GPX1|GPX2|GPX5|GPX6|PLA2G12A|PLA2G1B|PTGS2,
Endocytosis,KEGG:hsa04144,1.65E-08,2.34E-05,16,260/43037 genes: 0.60%,ARFGEF2|EGF|EGFR|ERBB3|ERBB4|FGFR4|HSPA1B|HSPA2|IGF1R|IGF2R|KIT|LDLR|NTRK1|PDGFRA|RET|TGFB1,
TGF-beta signaling pathway,KEGG:hsa04350,1.73E-08,2.44E-05,10,84/43037 genes: 0.20%,ACVR1C|CREBBP|IFNG|INHBB|MAPK1|MAPK3|MYC|RPS6KB2|TGFB1|TNF,
TP53 Regulates Transcription of Cell Death Genes,REACT:R-HSA-5633008,1.86E-08,2.63E-05,8,45/43037 genes: 0.10%,APAF1|BAX|BID|CREBBP|FAS|PMAIP1|TNFRSF10B|TP53,
Pre-NOTCH Transcription and Translation,REACT:R-HSA-1912408,1.97E-08,2.78E-05,7,30/43037 genes: 0.07%,CCND1|CREBBP|JUN|NOTCH2|NOTCH3|NOTCH4|TP53,
Serotonergic synapse,KEGG:hsa04726,2.57E-08,3.63E-05,11,112/43037 genes: 0.26%,APP|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CASP3|DDC|GABRB1|MAPK1|MAPK3|PTGS2,
Rheumatoid arthritis,KEGG:hsa05323,3.04E-08,4.29E-05,10,89/43037 genes: 0.21%,CD86|CXCL8|FOS|IFNG|IL1B|IL6|ITGAL|JUN|TGFB1|TNF,
Long-term potentiation,KEGG:hsa04720,3.08E-08,4.35E-05,9,67/43037 genes: 0.16%,CACNA1C|CAMK2B|CAMK2G|CREBBP|GRIA2|GRIN1|GRIN2B|MAPK1|MAPK3,
"Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways",REACT:R-HSA-168643,3.17E-08,4.48E-05,8,48/43037 genes: 0.11%,APP|BCL2|BCL2L1|CASP4|CASP8|CASP9|PYCARD|RIPK2,
Wnt signaling pathway,KEGG:hsa04310,3.53E-08,4.98E-05,12,143/43037 genes: 0.33%,CAMK2B|CAMK2G|CCND1|CREBBP|CSNK2A1|CTNNB1|GSK3B|JUN|MMP7|MYC|NKD2|TP53,
Membrane Trafficking,REACT:R-HSA-199991,3.54E-08,5.00E-05,24,613/43037 genes: 1.42%,APOB|APP|AVP|CD4|CTTN|EGF|EGFR|FTL|GJA1|GJB1|GJB2|IGF2R|INS|KLC1|LDLR|MYH1|MYH8|PACSIN1|RABGAP1|SLC2A4|SPTBN2|TF|TSC2|YWHAG,
Androgen biosynthesis,REACT:R-HSA-193048,5.02E-08,7.09E-05,5,11/43037 genes: 0.03%,CGA|CYP17A1|LHB|POMC|SRD5A2,
African trypanosomiasis,KEGG:hsa05143,5.02E-08,7.09E-05,7,34/43037 genes: 0.08%,FAS|FASLG|IFNG|IL1B|IL6|TLR9|TNF,
Activation of caspases through apoptosome-mediated cleavage,REACT:R-HSA-111459,5.54E-08,7.83E-05,4,5/43037 genes: 0.01%,APAF1|CASP3|CASP9|CYCS,
Cytochrome c-mediated apoptotic response,REACT:R-HSA-111461,5.54E-08,7.83E-05,4,5/43037 genes: 0.01%,APAF1|CASP3|CASP9|CYCS,
Hematopoietic cell lineage,KEGG:hsa04640,6.32E-08,8.93E-05,10,96/43037 genes: 0.22%,CD36|CD38|CD4|CD44|EPO|IL1B|IL4|IL6|KIT|TNF,
SHC1 events in ERBB2 signaling,REACT:R-HSA-1250196,7.56E-08,1.07E-04,6,22/43037 genes: 0.05%,EGF|EGFR|ERBB2|ERBB3|ERBB4|NRG1,
Choline metabolism in cancer,KEGG:hsa05231,8.49E-08,1.20E-04,10,99/43037 genes: 0.23%,EGF|EGFR|FOS|JUN|MAPK1|MAPK3|PDGFRA|PDGFRB|RPS6KB2|TSC2,
"Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate",KEGG:hsa_M00104,8.53E-08,1.20E-04,5,12/43037 genes: 0.03%,AKR1C4|CYP27A1|CYP7A1|CYP8B1|HSD17B4,
Glycoprotein hormones,REACT:R-HSA-209822,8.53E-08,1.20E-04,5,12/43037 genes: 0.03%,CGA|FSHB|INHBB|LHB|TSHB,
Allograft rejection,KEGG:hsa05330,9.35E-08,1.32E-04,7,37/43037 genes: 0.09%,CD40LG|CD86|FAS|FASLG|IFNG|IL4|TNF,
Regulation of cholesterol biosynthesis by SREBP (SREBF),REACT:R-HSA-1655829,9.60E-08,1.36E-04,8,55/43037 genes: 0.13%,ACACA|CREBBP|FASN|IDI1|MED1|RXRA|SQLE|SREBF1,
Autophagy - animal,KEGG:hsa04140,1.03E-07,1.45E-04,11,128/43037 genes: 0.30%,BCL2|BCL2L1|CTSD|IGF1R|INS|IRS2|MAPK1|MAPK3|RPS6KB2|RRAS|TSC2,
L1CAM interactions,REACT:R-HSA-373760,1.03E-07,1.45E-04,10,101/43037 genes: 0.23%,CSNK2A1|DLG1|DLG4|EGFR|MAPK1|MAPK3|NRCAM|RDX|SCN5A|SPTBN2,
Melanogenesis,KEGG:hsa04916,1.03E-07,1.45E-04,10,101/43037 genes: 0.23%,CAMK2B|CAMK2G|CREB1|CREBBP|CTNNB1|GSK3B|KIT|MAPK1|MAPK3|POMC,
RHO GTPases Activate NADPH Oxidases,REACT:R-HSA-5668599,1.37E-07,1.94E-04,5,13/43037 genes: 0.03%,CYBA|NCF1|NCF2|NCF4|NOX1,
Natural killer cell mediated cytotoxicity,KEGG:hsa04650,1.41E-07,1.99E-04,11,132/43037 genes: 0.31%,BID|CASP3|FAS|FASLG|FYN|IFNG|ITGAL|MAPK1|MAPK3|TNF|TNFRSF10B,
"C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone",KEGG:hsa_M00109,1.65E-07,2.33E-04,4,6/43037 genes: 0.01%,CYP11B1|CYP11B2|CYP17A1|CYP21A2,
Mineralocorticoid biosynthesis,REACT:R-HSA-193993,1.65E-07,2.33E-04,4,6/43037 genes: 0.01%,CGA|CYP11B2|CYP21A2|LHB,
Synthesis of 15-eicosatetraenoic acid derivatives,REACT:R-HSA-2142770,1.65E-07,2.33E-04,4,6/43037 genes: 0.01%,GPX1|GPX2|GPX4|PTGS2,
Arachidonic acid metabolism,REACT:R-HSA-2142753,1.93E-07,2.73E-04,8,60/43037 genes: 0.14%,CYP1A1|CYP1B1|CYP8B1|EPHX2|GPX1|GPX2|GPX4|PTGS2,
Collagen degradation,REACT:R-HSA-1442490,1.97E-07,2.78E-04,7,41/43037 genes: 0.10%,COL16A1|CTSD|MMP10|MMP13|MMP7|MMP8|MMP9,
Graft-versus-host disease,KEGG:hsa05332,1.97E-07,2.78E-04,7,41/43037 genes: 0.10%,CD86|FAS|FASLG|IFNG|IL1B|IL6|TNF,
Senescence-Associated Secretory Phenotype (SASP),REACT:R-HSA-2559582,2.31E-07,3.27E-04,10,110/43037 genes: 0.26%,CEBPB|CXCL8|FOS|IL6|JUN|MAPK1|MAPK3|NFKB1|RELA|STAT3,
Signaling pathways regulating pluripotency of stem cells,KEGG:hsa04550,2.38E-07,3.37E-04,11,139/43037 genes: 0.32%,ACVR1C|CTNNB1|FGFR4|GSK3B|IGF1|IGF1R|INHBB|MAPK1|MAPK3|MYC|STAT3,
TP53 Regulates Metabolic Genes,REACT:R-HSA-5628897,2.52E-07,3.55E-04,9,85/43037 genes: 0.20%,CYCS|GLS|GPX2|GSR|PRDX1|PRDX2|TP53|TSC2|YWHAG,
Integration of energy metabolism,REACT:R-HSA-163685,2.52E-07,3.56E-04,10,111/43037 genes: 0.26%,ACACA|ADIPOQ|CACNA1A|CACNA1C|CACNA1D|CACNB3|FASN|INS|PKLR|STXBP1,
Signaling by NOTCH,REACT:R-HSA-157118,2.74E-07,3.87E-04,10,112/43037 genes: 0.26%,CCND1|CREB1|CREBBP|HDAC1|JUN|MYC|NOTCH2|NOTCH3|NOTCH4|TP53,
Signaling by ERBB4,REACT:R-HSA-1236394,2.78E-07,3.92E-04,7,43/43037 genes: 0.10%,EGF|EGFR|ERBB3|ERBB4|ESR1|NRG1|PGR,
Type I diabetes mellitus,KEGG:hsa04940,2.78E-07,3.92E-04,7,43/43037 genes: 0.10%,CD86|FAS|FASLG|IFNG|IL1B|INS|TNF,
Cardiac conduction,REACT:R-HSA-5576891,2.96E-07,4.18E-04,11,142/43037 genes: 0.33%,CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7|CAMK2B|CAMK2G|SCN5A,
Cell adhesion molecules (CAMs),KEGG:hsa04514,3.18E-07,4.49E-04,11,143/43037 genes: 0.33%,CADM1|CD4|CD40LG|CD86|CDH2|CLDN7|ITGAL|NLGN1|NRCAM|NRXN1|NRXN2,
"Lipid digestion, mobilization, and transport",REACT:R-HSA-73923,3.51E-07,4.96E-04,10,115/43037 genes: 0.27%,ABCG8|ALB|APOB|APOE|FABP3|FABP4|FYN|LDLR|LIPF|RELN,
Dorso-ventral axis formation,KEGG:hsa04320,3.62E-07,5.12E-04,6,28/43037 genes: 0.07%,EGFR|MAPK1|MAPK3|NOTCH2|NOTCH3|NOTCH4,
Mitophagy - animal,KEGG:hsa04137,3.64E-07,5.14E-04,8,65/43037 genes: 0.15%,BCL2L1|CSNK2A1|FOXO3|JUN|PRKN|RELA|RRAS|TP53,
Apoptotic factor-mediated response,REACT:R-HSA-111471,3.82E-07,5.39E-04,4,7/43037 genes: 0.02%,APAF1|CASP3|CASP9|CYCS,
Transcriptional activation of mitochondrial biogenesis,REACT:R-HSA-2151201,3.84E-07,5.42E-04,7,45/43037 genes: 0.10%,CREB1|CREBBP|CYCS|MED1|PPARGC1A|RXRA|TFAM,
TAK1 activates NFkB by phosphorylation and activation of IKKs complex,REACT:R-HSA-445989,4.53E-07,6.40E-04,6,29/43037 genes: 0.07%,APP|NFKB1|NFKBIA|NFKBIB|RELA|RIPK2,
GRB2 events in ERBB2 signaling,REACT:R-HSA-1963640,4.54E-07,6.42E-04,5,16/43037 genes: 0.04%,EGF|EGFR|ERBB2|ERBB4|NRG1,
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors,REACT:R-HSA-8866910,4.54E-07,6.42E-04,5,16/43037 genes: 0.04%,CGA|EGFR|ERBB2|ESR1|KIT,
Chemokine signaling pathway,KEGG:hsa04062,4.92E-07,6.96E-04,12,182/43037 genes: 0.42%,CXCL8|FOXO3|GSK3B|MAPK1|MAPK3|NCF1|NFKB1|NFKBIA|NFKBIB|RELA|STAT3|STAT5B,
Pre-NOTCH Expression and Processing,REACT:R-HSA-1912422,5.23E-07,7.39E-04,7,47/43037 genes: 0.11%,CCND1|CREBBP|JUN|NOTCH2|NOTCH3|NOTCH4|TP53,
Downregulation of ERBB2 signaling,REACT:R-HSA-8863795,5.61E-07,7.93E-04,6,30/43037 genes: 0.07%,EGF|EGFR|ERBB2|ERBB3|ERBB4|NRG1,
Signaling by Rho GTPases,REACT:R-HSA-194315,5.98E-07,8.44E-04,18,425/43037 genes: 0.99%,ACTB|ACTG1|AR|CHN2|CTNNB1|CTTN|CYBA|DLG4|KLC1|KLK3|MAPK1|MAPK3|NCF1|NCF2|NCF4|NOX1|PFN1|YWHAG,
Fatty acid metabolism,KEGG:hsa01212,6.07E-07,8.57E-04,7,48/43037 genes: 0.11%,ACACA|ACADM|ACADS|ACOX1|CPT1A|ELOVL2|FASN,
Primary bile acid biosynthesis,KEGG:hsa00120,6.38E-07,9.02E-04,5,17/43037 genes: 0.04%,AKR1C4|CYP27A1|CYP7A1|CYP8B1|HSD17B4,
EPH-Ephrin signaling,REACT:R-HSA-2682334,6.55E-07,9.26E-04,9,95/43037 genes: 0.22%,ACTB|ACTG1|CFL1|EPHA3|EPHA8|FYN|GRIN1|GRIN2B|MMP9,
Activation of BH3-only proteins,REACT:R-HSA-114452,6.90E-07,9.75E-04,6,31/43037 genes: 0.07%,BCL2|BCL2L11|BID|PMAIP1|TP53|YWHAG,
Oocyte meiosis,KEGG:hsa04114,7.07E-07,1.00E-03,10,124/43037 genes: 0.29%,AR|CAMK2B|CAMK2G|IGF1|IGF1R|INS|MAPK1|MAPK3|PGR|YWHAG,
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR),REACT:R-HSA-5603027,7.57E-07,0.00107,4,8/43037 genes: 0.02%,NFKB1|NFKBIA|NFKBIB|RELA,
Death Receptor Signalling,REACT:R-HSA-73887,8.08E-07,0.00114,7,50/43037 genes: 0.12%,CASP8|FAS|FASLG|RACK1|SMPD3|TNF|TNFRSF10B,
Signaling by ERBB2,REACT:R-HSA-1227986,8.08E-07,0.00114,7,50/43037 genes: 0.12%,EGF|EGFR|ERBB2|ERBB3|ERBB4|FYN|NRG1,
Amine-derived hormones,REACT:R-HSA-209776,8.76E-07,0.00124,5,18/43037 genes: 0.04%,CGA|DDC|DIO2|TPO|TSHB,
Activation of Matrix Metalloproteinases,REACT:R-HSA-1592389,1.02E-06,0.00144,6,33/43037 genes: 0.08%,MMP10|MMP13|MMP17|MMP7|MMP8|MMP9,
"ROS, RNS production in phagocytes",REACT:R-HSA-1222556,1.02E-06,0.00144,6,33/43037 genes: 0.08%,CYBA|NCF1|NCF2|NCF4|NOS2|NOS3,
"C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone",KEGG:hsa_M00108,1.09E-06,0.00154,3,3/43037 genes: 0.01%,CYP11B1|CYP11B2|CYP21A2,
Formation of apoptosome,REACT:R-HSA-111458,1.09E-06,0.00154,3,3/43037 genes: 0.01%,APAF1|CASP9|CYCS,
Oligomerization of connexins into connexons,REACT:R-HSA-190704,1.09E-06,0.00154,3,3/43037 genes: 0.01%,GJA1|GJB1|GJB2,
Transport of connexins along the secretory pathway,REACT:R-HSA-190827,1.09E-06,0.00154,3,3/43037 genes: 0.01%,GJA1|GJB1|GJB2,
Ras activation uopn Ca2+ infux through NMDA receptor,REACT:R-HSA-442982,1.18E-06,0.00167,5,19/43037 genes: 0.04%,CAMK2B|CAMK2G|DLG4|GRIN1|GRIN2B,
Glucagon signaling pathway,KEGG:hsa04922,1.30E-06,0.00184,9,103/43037 genes: 0.24%,ACACA|CAMK2B|CAMK2G|CPT1A|CREB1|CREBBP|FBP1|PCK1|PPARGC1A,
Mitochondrial biogenesis,REACT:R-HSA-1592230,1.38E-06,0.00195,7,54/43037 genes: 0.13%,CREB1|CREBBP|CYCS|MED1|PPARGC1A|RXRA|TFAM,
Metabolism of amino acids and derivatives,REACT:R-HSA-71291,1.45E-06,0.00205,16,362/43037 genes: 0.84%,ARG1|CARNS1|CGA|CKMT2|DDC|DIO2|FOLH1|GCLC|GLS|GPT|GSR|INMT|OGDH|RPL17|TPO|TSHB,
Cardiac muscle contraction,KEGG:hsa04260,1.50E-06,0.00212,8,78/43037 genes: 0.18%,CACNA1C|CACNA1D|CACNA2D3|CACNB1|CACNB3|CACNG2|CACNG6|CACNG7,
Clathrin-mediated endocytosis,REACT:R-HSA-8856828,1.77E-06,0.00249,10,137/43037 genes: 0.32%,APOB|AVP|CD4|CTTN|EGF|EGFR|IGF2R|LDLR|PACSIN1|TF,
Apelin signaling pathway,KEGG:hsa04371,1.89E-06,0.00266,10,138/43037 genes: 0.32%,CCND1|MAPK1|MAPK3|NOS2|NOS3|NOTCH3|PPARGC1A|RPS6KB2|RRAS|TFAM,
Arginine biosynthesis,KEGG:hsa00220,2.03E-06,0.00287,5,21/43037 genes: 0.05%,ARG1|GLS|GPT|NOS2|NOS3,
RIP-mediated NFkB activation via ZBP1,REACT:R-HSA-1810476,2.03E-06,0.00287,5,21/43037 genes: 0.05%,APP|NFKB1|NFKBIA|NFKBIB|RELA,
SALM protein interactions at the synapses,REACT:R-HSA-8849932,2.03E-06,0.00287,5,21/43037 genes: 0.05%,DLG1|DLG4|GRIA4|GRIN1|GRIN2B,
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,REACT:R-HSA-6803204,2.03E-06,0.00287,5,21/43037 genes: 0.05%,BAX|BID|CREBBP|PMAIP1|TP53,
Activation of the AP-1 family of transcription factors,REACT:R-HSA-450341,2.23E-06,0.00316,4,10/43037 genes: 0.02%,FOS|JUN|MAPK1|MAPK3,
Signal attenuation,REACT:R-HSA-74749,2.23E-06,0.00316,4,10/43037 genes: 0.02%,INS|IRS2|MAPK1|MAPK3,
Thyroxine biosynthesis,REACT:R-HSA-209968,2.23E-06,0.00316,4,10/43037 genes: 0.02%,CGA|DIO2|TPO|TSHB,
Peroxisome,KEGG:hsa04146,2.42E-06,0.00342,8,83/43037 genes: 0.19%,ACOX1|CAT|EPHX2|HSD17B4|NOS2|NUDT7|PRDX1|SOD1,
Transmembrane transport of small molecules,REACT:R-HSA-382551,2.82E-06,0.00398,22,676/43037 genes: 1.57%,ABCB1|ABCC2|ABCC3|ABCG2|ABCG8|ALB|ATP8B4|AVP|CAMK2B|CAMK2G|FTL|GABRA4|GABRB1|RUNX1|SLC1A2|SLC1A6|SLC22A7|SLC2A4|SLC6A3|TF|TRPV4|TSC22D3,
Alcoholism,KEGG:hsa05034,3.09E-06,0.00436,11,180/43037 genes: 0.42%,BDNF|CREB1|DDC|GRIN1|GRIN2B|H2AFY2|HDAC1|MAPK1|MAPK3|NTRK2|SLC6A3,
HSF1-dependent transactivation,REACT:R-HSA-3371571,3.30E-06,0.00466,5,23/43037 genes: 0.05%,CAMK2B|CAMK2G|CREBBP|HSPA1B|HSPA2,
Tryptophan metabolism,KEGG:hsa00380,3.32E-06,0.0047,6,40/43037 genes: 0.09%,CAT|CYP1A1|CYP1B1|DDC|INMT|OGDH,
CASP8 activity is inhibited,REACT:R-HSA-5218900,3.48E-06,0.00492,4,11/43037 genes: 0.03%,CASP8|FAS|FASLG|TNFRSF10B,
Dimerization of procaspase-8,REACT:R-HSA-69416,3.48E-06,0.00492,4,11/43037 genes: 0.03%,CASP8|FAS|FASLG|TNFRSF10B,
Ligand-independent caspase activation via DCC,REACT:R-HSA-418889,3.48E-06,0.00492,4,11/43037 genes: 0.03%,CASP3|CASP9|DCC|UNC5B,
Regulation by c-FLIP,REACT:R-HSA-3371378,3.48E-06,0.00492,4,11/43037 genes: 0.03%,CASP8|FAS|FASLG|TNFRSF10B,
GABAergic synapse,KEGG:hsa04727,3.77E-06,0.00532,8,88/43037 genes: 0.20%,CACNA1A|CACNA1B|CACNA1C|CACNA1D|GABRA4|GABRB1|GLS|TRAK2,
Fat digestion and absorption,KEGG:hsa04975,3.86E-06,0.00546,6,41/43037 genes: 0.10%,ABCG8|APOB|CD36|LIPF|PLA2G12A|PLA2G1B,
Cytosolic DNA-sensing pathway,KEGG:hsa04623,3.99E-06,0.00564,7,63/43037 genes: 0.15%,IL1B|IL6|NFKB1|NFKBIA|NFKBIB|PYCARD|RELA,
Cellular response to heat stress,REACT:R-HSA-3371556,4.10E-06,0.0058,8,89/43037 genes: 0.21%,CAMK2B|CAMK2G|CREBBP|GSK3B|HSPA1B|HSPA2|MAPK1|MAPK3,
Diseases associated with the TLR signaling cascade,REACT:R-HSA-5602358,4.13E-06,0.00584,5,24/43037 genes: 0.06%,CD36|NFKB1|NFKBIA|NFKBIB|RELA,
Diseases of Immune System,REACT:R-HSA-5260271,4.13E-06,0.00584,5,24/43037 genes: 0.06%,CD36|NFKB1|NFKBIA|NFKBIB|RELA,
Glutamate Neurotransmitter Release Cycle,REACT:R-HSA-210500,4.13E-06,0.00584,5,24/43037 genes: 0.06%,GLS|PPFIA3|SLC1A2|SLC1A6|STXBP1,
Apoptotic machinery,KEGG:hsa_M00685,4.33E-06,0.00612,3,4/43037 genes: 0.01%,APAF1|CASP3|CASP9,
Defective LFNG causes SCDO3,REACT:R-HSA-5083630,4.33E-06,0.00612,3,4/43037 genes: 0.01%,NOTCH2|NOTCH3|NOTCH4,
PLCG1 events in ERBB2 signaling,REACT:R-HSA-1251932,4.33E-06,0.00612,3,4/43037 genes: 0.01%,EGF|EGFR|ERBB2,
MAP kinase activation in TLR cascade,REACT:R-HSA-450294,4.44E-06,0.00627,7,64/43037 genes: 0.15%,CREB1|FOS|JUN|MAPK1|MAPK3|NFKB1|RIPK2,
EPHB-mediated forward signaling,REACT:R-HSA-3928662,4.47E-06,0.00631,6,42/43037 genes: 0.10%,ACTB|ACTG1|CFL1|FYN|GRIN1|GRIN2B,
Phagosome,KEGG:hsa04145,4.77E-06,0.00674,10,153/43037 genes: 0.36%,ACTB|ACTG1|C1R|CD36|CYBA|MPO|NCF1|NCF2|NCF4|NOX1,
Retinol metabolism,KEGG:hsa00830,4.93E-06,0.00697,7,65/43037 genes: 0.15%,CYP1A1|CYP26A1|CYP2B6|CYP3A4|RDH12|UGT2A3|UGT2B17,
Hippo signaling pathway,KEGG:hsa04390,5.06E-06,0.00714,10,154/43037 genes: 0.36%,ACTB|ACTG1|CCND1|CTNNB1|DLG1|DLG4|GSK3B|MYC|TGFB1|YWHAG,
TRAF6 mediated NF-kB activation,REACT:R-HSA-933542,5.12E-06,0.00724,5,25/43037 genes: 0.06%,APP|NFKB1|NFKBIA|NFKBIB|RELA,
ZBP1(DAI) mediated induction of type I IFNs,REACT:R-HSA-1606322,5.12E-06,0.00724,5,25/43037 genes: 0.06%,APP|NFKB1|NFKBIA|NFKBIB|RELA,
Activation of Ca-permeable Kainate Receptor,REACT:R-HSA-451308,5.18E-06,0.00732,4,12/43037 genes: 0.03%,DLG1|DLG4|GRIK1|GRIK2,
Ionotropic activity of Kainate Receptors,REACT:R-HSA-451306,5.18E-06,0.00732,4,12/43037 genes: 0.03%,DLG1|DLG4|GRIK1|GRIK2,
ABC transporters,KEGG:hsa02010,5.91E-06,0.00834,6,44/43037 genes: 0.10%,ABCB1|ABCB11|ABCC2|ABCC3|ABCG2|ABCG8,
Retinoid metabolism and transport,REACT:R-HSA-975634,5.91E-06,0.00834,6,44/43037 genes: 0.10%,AKR1B10|AKR1C4|APOB|APOE|LDLR|TTR,
Cell cycle,KEGG:hsa04110,6.09E-06,0.0086,9,124/43037 genes: 0.29%,CCND1|CREBBP|GADD45B|GSK3B|HDAC1|MYC|TGFB1|TP53|YWHAG,
Cytosolic sensors of pathogen-associated DNA,REACT:R-HSA-1834949,6.69E-06,0.00945,7,68/43037 genes: 0.16%,APP|CREBBP|CTNNB1|NFKB1|NFKBIA|NFKBIB|RELA,
Epithelial cell signaling in Helicobacter pylori infection,KEGG:hsa05120,6.69E-06,0.00945,7,68/43037 genes: 0.16%,CASP3|CXCL8|EGFR|JUN|NFKB1|NFKBIA|RELA,
Cellular Senescence,REACT:R-HSA-2559583,6.98E-06,0.00986,11,196/43037 genes: 0.46%,CEBPB|CXCL8|FOS|IL6|JUN|MAPK1|MAPK3|NFKB1|RELA|STAT3|TP53,