Dieldrin:  Pathways related to data in the Comparative Toxicogenomics Database,,,,,,,
Pathway,Pathway ID,P-value,Corrected P-value,Annotated Genes Quantity,Genome Frequency,Annotated Genes,
Signal Transduction,REACT:R-HSA-162582,3.23E-108,6.07E-105,266,2587/43037 genes: 6.01%,ACTB|ACVR1C|ADAM17|ADRA2B|ADRB1|ADRB2|AGT|AKT2|ANXA1|APOA1|APOB|APOE|APP|AR|ARAF|ARHGEF5|ARHGEF6|ARRB2|ASH2L|ATF1|ATP2A2|AURKB|AVPR1B|AXIN2|BCL2L11|BEX3|BIRC2|BIRC3|BIRC5|BOC|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP3|CASP8|CASP9|CCKBR|CCL1|CCND1|CCNE1|CCNT1|CCNT2|CDC20|CDC25C|CDCA8|CDK1|CDK2|CDKN1A|CENPE|CENPF|CENPO|CGA|CGN|CHRM1|CHRM2|CHRM4|CHRM5|CIT|CORT|CREB1|CRH|CRHBP|CRK|CSNK1E|CUL1|CUL5|CYP26A1|DERL2|DGKI|DNAJB1|DRD3|DRD4|DUSP1|E2F1|E2F5|ECE1|ECT2|EGFR|EIF4G1|ELK1|ERBB3|ERBIN|ESR1|F2|FADD|FES|FGB|FGD1|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FLT4|FOXO3|FSHB|FST|FYN|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|GCG|GDI1|GFAP|GFRA1|GNRH1|GNRHR|GPR17|GRIN1|GRIN2B|GRIN2C|GRK2|GRM5|GTF2F1|H2AFZ|HDAC8|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|IGF1|IL6|INS|IQGAP1|ITGA2B|JAG1|JUN|JUNB|KDR|KIF7|KIT|LAMA5|LAMB1|LDLR|LHB|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MDK|MDM2|MEN1|MET|METAP2|MMP9|MRTFA|MTOR|MYC|MYD88|MYLK|NAPEPLD|NCF4|NDC80|NEDD8|NEFL|NET1|NFKB1|NGF|NMT1|NOTCH1|NOTCH2|NOX1|NPY|NSMAF|NTRK1|NTRK2|NTS|NUF2|NUP133|PARD6A|PARP1|PDGFA|PDGFC|PDGFRA|PDGFRB|PDK1|PDK4|PELP1|PENK|PGF|PGR|PIK3R2|PLCB1|PLG|PLK1|POLR2B|POLR2F|POMC|PPP2R1A|PPP3R1|PRC1|PRKAB1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|PTCH2|PTH2|RACGAP1|RAF1|RAP1A|RARA|RARB|RARG|RET|RGS18|RGS2|RIPK2|RSPO3|RTN4|RXRA|SAV1|SFRP2|SMARCA4|SMPD3|SOX6|SQSTM1|SRC|SSTR3|STK3|SUFU|SYVN1|TAC1|TAX1BP3|TCF7|TCIRG1|TFDP2|TGFB1|TIAL1|TJP1|TLE1|TNF|TNFRSF1A|TP53|TRADD|TRIB3|TSC1|TSC2|VCP|VEGFA|VEGFB|VEGFC|VIPR2|WASF2|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B|WWOX,
Immune System,REACT:R-HSA-168256,8.03E-80,1.51E-76,209,2118/43037 genes: 4.92%,ACLY|ACTB|ADAM17|AKT2|ALOX15|ALOX5|ANAPC7|ANXA1|AP1M2|APAF1|APOB|APP|ARAF|ARRB2|ARSB|ASB16|ASB3|ASB6|ATAD3B|ATF1|ATF2|ATG7|BCL2|BCL2L1|BCL6|BIRC2|BIRC3|BIRC5|C1R|C1S|C8B|CALM2|CALR|CAMK2A|CAMK2B|CAMK2G|CAND1|CARD9|CASP3|CASP4|CASP8|CASP9|CAT|CCND1|CCNF|CD3G|CDC20|CDC23|CDC26|CDC34|CDK13|CDKN1A|CEBPD|CENPE|CFH|CFI|CHRNB4|COPB1|CREB1|CRK|CSTB|CTSB|CTSD|CUL1|CUL2|CUL5|DCTN2|DEGS1|DNAJC3|DUSP1|EGFR|EIF4E3|EIF4G1|ELK1|ERBB3|FADD|FAF2|FBXO2|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FOXO3|FYN|FZR1|GFRA1|GH1|GRIN1|GRIN2B|GRIN2C|GRK2|HERC2|HMOX1|HSP90B1|HSPA1A|IFITM1|IL10|IL10RB|IL18|IL1B|IL6|INPP5D|INS|IQGAP1|IRAK3|ISG15|ISG20|ITGA2B|ITGB7|JUN|JUNB|KEAP1|KIF20A|KIF23|KIT|LAMA5|LAMP1|LCN2|LGMN|LRSAM1|LTA4H|MAN2B1|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MDM2|MET|MGST1|MMP9|MTOR|MYC|MYD88|NCF4|NDN|NEFL|NFKB1|NPC2|NUP133|NUP214|P2RX7|PCBP2|PDGFA|PDGFRA|PDGFRB|PDIA3|PIK3R2|PNP|POLR2F|POLR3H|POMC|PPP2R1A|PPP3R1|PRDX6|PRKCD|PRL|PSEN1|PSMA2|PSMA4|PSMC4|PSMD1|PYCARD|QPCT|RACGAP1|RAE1|RAF1|RAP1A|RET|RIPK2|RNASET2|RNF34|SEC22B|SIPA1|SMARCA4|SNAP23|SNAP25|SQSTM1|SRC|STBD1|SUGT1|TCIRG1|TGFB1|TNF|TNFRSF1A|TP53|TRAIP|TRIB3|TRIP12|TRPC1|TSC2|UBE2C|UBE2R2|VAMP8|VCP|VEGFA|VHL|WASF2|XDH|ZBTB16,
Pathways in cancer,KEGG:hsa05200,9.58E-77,1.80E-73,100,395/43037 genes: 0.92%,AKT2|AR|ARAF|AXIN2|BAX|BCL2|BCL2L1|BID|BIRC2|BIRC3|BIRC5|BRCA2|CASP3|CASP8|CASP9|CCDC6|CCND1|CCNE1|CCNE2|CDK2|CDK6|CDKN1A|CRK|CUL2|CYCS|E2F1|EGFR|EGLN3|FADD|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FOS|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|HSP90B1|IGF1|IL6|ITGA2B|JUN|KIT|LAMA5|LAMB1|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MDM2|MET|MMP9|MSH2|MSH6|MTOR|MYC|NCOA4|NFKB1|NTRK1|PDGFA|PDGFRA|PDGFRB|PGF|PIK3R2|PLCB1|PTCH2|RAF1|RARA|RARB|RB1|RET|RXRA|SUFU|TCF7|TGFB1|TGFB3|TP53|VEGFA|VEGFB|VEGFC|VHL|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B|ZBTB16,
Metabolism,REACT:R-HSA-1430728,1.67E-75,3.13E-72,206,2172/43037 genes: 5.05%,AADAC|ABCB1|ABCC1|ABCC8|ABCG2|ACADS|ACLY|ACOT11|ACOX3|ACP5|ACSF2|ACSL4|ACSL5|ACSM3|ADH5|ADSL|AGT|AGXT2|AHR|AIMP1|AIMP2|ALB|ALDH7A1|ALOX15|ALOX5|APOA1|APOB|APOE|ARSB|ATP5F1A|ATP5F1B|ATP6|B3GNT3|BCAT1|CALM2|CAT|CERS5|CGA|CHAC1|CHIA|CIDEA|CIDEC|COASY|COMT|COQ2|COX20|CPTP|CTRC|CYCS|CYP1A1|CYP1A2|CYP1B1|CYP26A1|CYP2B6|CYP3A4|CYP8B1|DBH|DCK|DEGS1|DHFR|DTYMK|EEF1E1|ELOVL7|ENO1|ENOPH1|ENTPD7|EPHX1|EPHX2|FGF21|FYN|G6PD|GALE|GALK1|GAPDH|GCG|GCLC|GGPS1|GMPS|GPT|GPX1|GPX4|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|GYG2|HBA1|HBA2|HIBADH|HK2|HMMR|HMOX1|HSD17B12|HSD3B1|IARS|IDH3B|INPP5D|INS|INSIG2|IQGAP1|KYAT1|LCT|LDLR|LGMN|LHB|LIAS|LMBRD1|LPIN2|LTA4H|MAN2B1|MARC1|MED17|MED28|MED30|MED6|MGST1|MGST2|MMADHC|MSMO1|NAGS|NAMPT|ND2|NDUFA12|NDUFAF6|NFYC|NNT|NPC1|NPC2|NUP133|NUP214|ODC1|OSBPL10|OSBPL7|PARP4|PC|PDK1|PDK4|PDSS1|PECR|PGD|PIK3R2|PLCB1|PLEKHA1|PLPP3|PNMT|PNP|POMC|PON1|PPOX|PPP2R1A|PPT1|PPT2|PRELP|PSMA2|PSMA4|PSMC4|PSMD1|PYGM|RAE1|RAP1A|RPIA|RPL6|RPS7|RPS8|RRM2|RXRA|SCARB1|SERINC3|SGPL1|SGPP1|SI|SIN3A|SLC10A1|SLC16A1|SLC16A8|SLC19A2|SLC22A1|SLC25A37|SLC2A2|SLC44A1|SLC44A4|SLC4A1|SLC5A6|SLC6A12|SLC6A8|SMPD3|SNAP25|SPTLC1|ST3GAL1|STAR|STXBP1|TH|TK1|TNFAIP8|TPH1|TPH2|TPI1|TRIB3|TYR|UBIAD1|UCP3|UGP2|UQCRH|UROS|XDH,
Gene Expression,REACT:R-HSA-74160,1.80E-59,3.37E-56,169,1831/43037 genes: 4.25%,ACTB|ADARB1|ADAT3|AIFM2|AIMP1|AIMP2|AKT2|ALKBH8|APAF1|APOE|AR|ATF2|ATM|AURKA|AURKB|BAX|BBC3|BCL2L14|BCL6|BID|BIRC5|BNIP3L|BRCA1|CCNB1|CCNE1|CCNE2|CCNH|CCNT1|CCNT2|CDC25C|CDK1|CDK13|CDK2|CDKN1A|CGA|CHEK2|COX20|CSNK1D|CSNK1E|CTU2|CYCS|DAXX|DDIT4|DDX39B|DDX4|DHX15|DHX16|DNA2|E2F1|E2F5|EED|EEF1E1|EGFR|EIF4G1|ELL2|ESR1|ESR2|EZH2|FANCC|FKBP6|FOS|G6PD|GADD45A|GTF2F1|GTF3C4|H2AFZ|HIPK1|HSPA1A|IARS|IARS2|INTS10|INTS4|JUN|JUNB|KIT|MAP2K6|MAPK3|MDC1|MDM2|MDM4|MED17|MED30|MED6|MEN1|MPHOSPH10|MPHOSPH6|MSH2|MTA3|MTOR|MYC|NOP2|NOTCH1|NOTCH2|NPM1|NR1I2|NR1I3|NR5A1|NR5A2|NUP133|NUP214|PARP1|PATL1|PCBP2|PCNA|PELP1|PGR|PIDD1|PIWIL2|PLAGL1|PLK2|POLR2B|POLR2F|POLR3H|PPP1R13B|PPP2R1A|PRDX2|PRELID1|PRKAB1|PRKCD|PRMT1|PSMA2|PSMA4|PSMC4|PSMD1|PUS1|QTRT1|RABGGTB|RAD1|RAE1|RARA|RARB|RARG|RBL2|RFC4|RNF34|RPL6|RPS7|RPS8|RXRA|SART1|SESN1|SF1|SGK1|SIN3A|SNRNP25|SNRNP40|SNRPD1|SRP68|SRSF5|STEAP3|TAF8|TDRD9|TFB1M|TFDP2|THRB|TOPBP1|TP53|TPRKB|TRMT6|TRMT61A|TRMU|TSC1|TSC2|TYW3|UTP14A|UTP15|VEGFA|WWOX|ZFP36,
Innate Immune System,REACT:R-HSA-168249,4.29E-57,8.05E-54,140,1298/43037 genes: 3.02%,ACLY|ACTB|AKT2|ALOX5|APAF1|APOB|APP|ARAF|ARRB2|ARSB|ATAD3B|ATF1|ATF2|ATG7|BCL2|BCL2L1|BIRC2|BIRC3|C1R|C1S|C8B|CALM2|CAMK2A|CAMK2B|CAMK2G|CAND1|CARD9|CASP4|CASP8|CASP9|CAT|CD3G|CDC34|CDK13|CDKN1A|CFH|CFI|CHRNB4|COPB1|CREB1|CRK|CSTB|CTSB|CTSD|CUL1|DEGS1|DNAJC3|DUSP1|EGFR|ELK1|ERBB3|FADD|FAF2|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|HSP90B1|HSPA1A|IL1B|INS|IQGAP1|IRAK3|ISG15|ITGA2B|JUN|KIT|LAMP1|LCN2|LGMN|LTA4H|MAN2B1|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MDM2|MET|MGST1|MMP9|MTOR|MYD88|NCF4|NEFL|NFKB1|NPC2|P2RX7|PCBP2|PDGFA|PDGFRA|PDGFRB|PIK3R2|PNP|POLR2F|POLR3H|PPP2R1A|PPP3R1|PRDX6|PRKCD|PSEN1|PSMA2|PSMA4|PSMC4|PSMD1|PYCARD|QPCT|RAF1|RAP1A|RET|RIPK2|RNASET2|SNAP23|SNAP25|SRC|STBD1|SUGT1|TCIRG1|TP53|TRIB3|TSC2|VAMP8|VCP|WASF2,
Breast cancer,KEGG:hsa05224,4.62E-55,8.66E-52,56,144/43037 genes: 0.33%,AKT2|ARAF|AXIN2|BRCA1|BRCA2|CCND1|CDK6|CDKN1A|E2F1|EGFR|ESR1|ESR2|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FLT4|FOS|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|IGF1|JAG1|JUN|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MTOR|MYC|NOTCH1|NOTCH2|PGR|PIK3R2|RAF1|RB1|TCF7|TP53|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Cell Cycle,REACT:R-HSA-1640170,1.02E-54,1.91E-51,98,621/43037 genes: 1.44%,AKT2|ANAPC7|ATM|AURKA|AURKB|BABAM2|BIRC5|BRCA1|BRCA2|CCNB1|CCNB2|CCND1|CCNE1|CCNE2|CCNH|CDC20|CDC23|CDC25B|CDC25C|CDC26|CDC6|CDC7|CDCA8|CDK1|CDK2|CDK6|CDKN1A|CDKN1C|CENPE|CENPF|CENPO|CEP164|CEP70|CETN2|CHEK2|CSNK1D|CSNK1E|CUL1|DCTN2|DHFR|DNA2|E2F1|E2F5|ESCO2|ESPL1|FBXO5|FKBP6|FZR1|H2AFZ|HAUS1|HAUS8|HDAC8|HERC2|HMMR|KIF20A|KIF23|LIG1|LIN9|LMNB1|LPIN2|MAPK1|MAPK3|MCM2|MDC1|MDM2|MDM4|MYC|NDC80|NPM1|NSD2|NUF2|NUP133|NUP214|ORC4|ORC5|PCNA|PHLDA1|PLK1|PLK4|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|RAD1|RAE1|RB1|RBL2|RFC4|RRM2|SMC1A|TFDP2|TOPBP1|TP53|TUBGCP2|UBE2C|WEE1,
Signaling by Interleukins,REACT:R-HSA-449147,3.54E-49,6.63E-46,86,528/43037 genes: 1.23%,ALOX15|ALOX5|ANXA1|ARAF|ARRB2|BCL2|BCL2L1|BCL6|BIRC5|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP3|CCND1|CDKN1A|CEBPD|CRK|CUL1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|HMOX1|HSP90B1|IL10|IL10RB|IL18|IL1B|IL6|INPP5D|IQGAP1|IRAK3|ITGA2B|JUNB|KIT|LAMA5|LCN2|MAP2K1|MAP2K2|MAP2K6|MAPK1|MAPK3|MET|MMP9|MYC|MYD88|NDN|NEFL|NFKB1|PDGFA|PDGFRA|PDGFRB|PIK3R2|POMC|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|RIPK2|SMARCA4|SQSTM1|SRC|TGFB1|TNF|TNFRSF1A|TP53|VEGFA,
Cytokine Signaling in Immune system,REACT:R-HSA-1280215,2.21E-48,4.15E-45,100,760/43037 genes: 1.77%,ADAM17|ALOX15|ALOX5|ANXA1|ARAF|ARRB2|BCL2|BCL2L1|BCL6|BIRC2|BIRC3|BIRC5|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP3|CCND1|CDKN1A|CEBPD|CRK|CUL1|DUSP1|EGFR|EIF4E3|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FOXO3|FYN|GFRA1|GH1|GRIN1|GRIN2B|GRIN2C|HMOX1|HSP90B1|IFITM1|IL10|IL10RB|IL18|IL1B|IL6|INPP5D|IQGAP1|IRAK3|ISG15|ISG20|ITGA2B|JUNB|KIT|LAMA5|LCN2|MAP2K1|MAP2K2|MAP2K6|MAPK1|MAPK3|MET|MMP9|MYC|MYD88|NDN|NEFL|NFKB1|NUP133|NUP214|PDGFA|PDGFRA|PDGFRB|PIK3R2|POMC|PPP2R1A|PRKCD|PRL|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|RAF1|RAP1A|RET|RIPK2|SMARCA4|SQSTM1|SRC|TGFB1|TNF|TNFRSF1A|TP53|VEGFA,
PI3K-Akt signaling pathway,KEGG:hsa04151,3.05E-48,5.73E-45,71,341/43037 genes: 0.79%,AKT2|ATF2|BCL2|BCL2L1|BCL2L11|BRCA1|CASP9|CCND1|CCNE1|CCNE2|CDK2|CDK6|CDKN1A|CHRM1|CHRM2|COL1A1|CREB1|DDIT4|EGFR|EPHA2|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FGFR4|FLT4|FOXO3|GH1|HSP90B1|IGF1|IL6|INS|ITGA2B|ITGB7|KDR|KIT|LAMA5|LAMB1|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|MYB|MYC|NFKB1|NGF|PDGFA|PDGFC|PDGFRA|PDGFRB|PGF|PIK3R2|PPP2R1A|PRL|RAF1|RBL2|RXRA|SGK1|TP53|TSC1|TSC2|VEGFA|VEGFB|VEGFC,
"Cell Cycle, Mitotic",REACT:R-HSA-69278,3.68E-48,6.90E-45,84,514/43037 genes: 1.19%,AKT2|ANAPC7|AURKA|AURKB|BIRC5|CCNB1|CCNB2|CCND1|CCNE1|CCNE2|CCNH|CDC20|CDC23|CDC25B|CDC25C|CDC26|CDC6|CDC7|CDCA8|CDK1|CDK2|CDK6|CDKN1A|CDKN1C|CENPE|CENPF|CENPO|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|CUL1|DCTN2|DHFR|DNA2|E2F1|E2F5|ESCO2|ESPL1|FBXO5|FZR1|H2AFZ|HAUS1|HAUS8|HDAC8|HMMR|KIF20A|KIF23|LIG1|LIN9|LMNB1|LPIN2|MAPK1|MAPK3|MCM2|MYC|NDC80|NUF2|NUP133|NUP214|ORC4|ORC5|PCNA|PHLDA1|PLK1|PLK4|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|RAE1|RB1|RBL2|RFC4|RRM2|SMC1A|TFDP2|TP53|TUBGCP2|UBE2C|WEE1,
Apoptosis,KEGG:hsa04210,1.95E-47,3.65E-44,50,138/43037 genes: 0.32%,ACTB|AIFM1|AKT2|APAF1|ATM|BAK1|BAX|BBC3|BCL2|BCL2L1|BCL2L11|BID|BIRC2|BIRC3|BIRC5|CASP12|CASP3|CASP7|CASP8|CASP9|CTSB|CTSD|CYCS|DAXX|DDIT3|DIABLO|FADD|FOS|GADD45A|GADD45G|HRK|JUN|LMNB1|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|NFKB1|NGF|NTRK1|PARP1|PARP4|PIDD1|PIK3R2|RAF1|TNF|TNFRSF1A|TP53|TRADD,
Disease,REACT:R-HSA-1643685,7.80E-47,1.46E-43,104,860/43037 genes: 2.00%,ABCC8|ADAM17|AKT2|ALB|AP1M2|APP|ARAF|ARRB2|ATG7|AVPR1B|BCL2L11|CALM2|CALR|CASP9|CCNH|CCNT1|CCNT2|CDC25B|CDC25C|CDKN1A|CHMP4C|CREB1|CUL1|CUL5|DERL2|DNAJC3|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FXR1|FYN|FZD6|FZD8|GRSF1|GTF2F1|GYG2|HDAC8|HSPA1A|IQGAP1|ISG15|ITGA2B|JAG1|JUN|KIT|LIG1|LMNB1|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK3|MDM2|MET|MMADHC|MTOR|MYC|MYD88|NAPEPLD|NFKB1|NMT1|NOTCH1|NOTCH2|NPM1|NUP133|NUP214|PC|PDGFA|PDGFRA|PDGFRB|PIK3R2|POLR2B|POLR2F|POMC|PPP2R1A|PRDX2|PRELP|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|RAF1|RAP1A|RPL6|RPS7|RPS8|SNAP25|SOD2|SRC|SYVN1|TGFB1|TSC2|VCP|VPS37C|WNT3A,
Transcriptional Regulation by TP53,REACT:R-HSA-3700989,9.22E-47,1.73E-43,72,370/43037 genes: 0.86%,AIFM2|AKT2|APAF1|ATF2|ATM|AURKA|AURKB|BAX|BBC3|BCL2L14|BCL6|BID|BIRC5|BNIP3L|BRCA1|CCNB1|CCNE1|CCNE2|CCNH|CCNT1|CCNT2|CDC25C|CDK1|CDK13|CDK2|CDKN1A|CHEK2|COX20|CYCS|DAXX|DDIT4|DNA2|E2F1|FANCC|FOS|G6PD|GADD45A|GTF2F1|HIPK1|JUN|MAP2K6|MDC1|MDM2|MDM4|MSH2|MTOR|NPM1|PCNA|PIDD1|PLAGL1|PLK2|POLR2B|POLR2F|PPP1R13B|PPP2R1A|PRDX2|PRELID1|PRKAB1|PRMT1|RABGGTB|RAD1|RBL2|RFC4|RNF34|SESN1|SGK1|STEAP3|TFDP2|TOPBP1|TP53|TSC1|TSC2,
Signalling by NGF,REACT:R-HSA-166520,9.11E-46,1.71E-42,79,477/43037 genes: 1.11%,ADAM17|AKT2|ARAF|ARHGEF5|ARHGEF6|ARRB2|ATF1|BCL2L11|BEX3|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP3|CASP9|CDKN1A|CREB1|CRK|DUSP1|ECT2|EGFR|ELK1|ERBB3|FGB|FGD1|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MDM2|MET|MTOR|MYD88|NEFL|NET1|NFKB1|NGF|NTRK1|NTRK2|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|RIPK2|RTN4|SQSTM1|SRC|TP53|TRIB3|TSC2,
Generic Transcription Pathway,REACT:R-HSA-212436,1.47E-44,2.76E-41,102,873/43037 genes: 2.03%,AIFM2|AKT2|APAF1|APOE|AR|ATF2|ATM|AURKA|AURKB|BAX|BBC3|BCL2L14|BCL6|BID|BIRC5|BNIP3L|BRCA1|CCNB1|CCNE1|CCNE2|CCNH|CCNT1|CCNT2|CDC25C|CDK1|CDK13|CDK2|CDKN1A|CGA|CHEK2|COX20|CYCS|DAXX|DDIT4|DNA2|E2F1|E2F5|EGFR|ESR1|ESR2|FANCC|FOS|G6PD|GADD45A|GTF2F1|HIPK1|JUN|JUNB|KIT|MAP2K6|MDC1|MDM2|MDM4|MED17|MED30|MED6|MEN1|MSH2|MTOR|MYC|NOP2|NOTCH1|NOTCH2|NPM1|NR1I2|NR1I3|NR5A1|NR5A2|PARP1|PCNA|PGR|PIDD1|PLAGL1|PLK2|POLR2B|POLR2F|PPP1R13B|PPP2R1A|PRDX2|PRELID1|PRKAB1|PRMT1|RABGGTB|RAD1|RARA|RARB|RARG|RBL2|RFC4|RNF34|RXRA|SESN1|SGK1|STEAP3|TFDP2|THRB|TOPBP1|TP53|TSC1|TSC2|VEGFA|WWOX,
Cell cycle,KEGG:hsa04110,2.73E-44,5.12E-41,46,124/43037 genes: 0.29%,ANAPC7|ATM|CCNB1|CCNB2|CCND1|CCNE1|CCNE2|CCNH|CDC20|CDC23|CDC25B|CDC25C|CDC26|CDC6|CDC7|CDK1|CDK2|CDK6|CDKN1A|CDKN1C|CHEK2|CUL1|E2F1|E2F5|ESPL1|FZR1|GADD45A|GADD45G|MCM2|MDM2|MYC|ORC4|ORC5|PCNA|PLK1|PTTG1|RB1|RBL2|SMC1A|TFDP2|TGFB1|TGFB3|TP53|TTK|WEE1|ZBTB17,
Proteoglycans in cancer,KEGG:hsa05205,5.84E-43,1.09E-39,54,203/43037 genes: 0.47%,ACTB|AKT2|ANK1|ARAF|CAMK2A|CAMK2B|CAMK2G|CASP3|CCND1|CDKN1A|EGFR|ELK1|ERBB3|ESR1|FGF2|FGFR1|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|IGF1|IQGAP1|KDR|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MDM2|MET|MMP9|MTOR|MYC|PIK3R2|RAF1|SRC|TGFB1|TIMP3|TNF|TP53|VEGFA|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
MAPK signaling pathway,KEGG:hsa04010,7.18E-42,1.35E-38,58,255/43037 genes: 0.59%,AKT2|ARRB2|ATF2|CASP3|CDC25B|CRK|DAXX|DDIT3|DUSP1|EGFR|ELK1|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FGFR4|FOS|GADD45A|GADD45G|HSPA1A|IL1B|JUN|JUND|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAP3K6|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MAPK8IP1|MAPT|MOS|MYC|NFKB1|NGF|NTF4|NTRK1|NTRK2|PDGFA|PDGFRA|PDGFRB|PPP3R1|RAF1|RAP1A|STK3|TGFB1|TGFB3|TNF|TNFRSF1A|TP53,
Metabolic pathways,KEGG:hsa01100,2.27E-41,4.26E-38,118,1270/43037 genes: 2.95%,ACADS|ACLY|ACO1|ACOX3|ACP5|ACSL4|ACSL5|ACSM3|ADH5|ADSL|AGXT2|ALDH7A1|ALOX15|ALOX5|ARSB|ATP5F1A|ATP5F1B|ATP6|B3GNT3|B4GALNT3|BCAT1|C1GALT1C1|CERS5|CHIA|COASY|COMT|COQ2|COX17|CYCS|CYP1A1|CYP1A2|CYP26A1|CYP2B6|CYP3A4|CYP8B1|DAD1|DBH|DCK|DEGS1|DGKI|DHFR|DOLK|DTYMK|ENO1|ENOPH1|EPHX2|G6PD|GAD2|GALE|GALK1|GAPDH|GCLC|GGPS1|GMPS|GPT|GYG2|HIBADH|HK2|HMOX1|HOGA1|HSD17B12|HSD3B1|IDH3B|KYAT1|LAMA5|LCT|LIAS|LPIN2|LTA4H|MAN2A1|MPI|MSMO1|NAGS|NAMPT|NAT8L|ND2|NDUFA12|NNT|ODC1|PC|PGD|PIGC|PIGS|PLCB1|PLPP3|PNMT|PNP|POLR2B|POLR2F|POLR3H|POMT1|PON1|PPOX|PPT1|PPT2|PRDX6|PYGM|QRSL1|RPIA|RRM2|SDSL|SGPL1|SI|SMPD3|SPTLC1|ST3GAL1|ST6GAL1|TCIRG1|TH|TK1|TPH1|TPH2|TPI1|TYR|UGP2|UQCRH|UROS|XDH,
Cellular responses to stress,REACT:R-HSA-2262752,1.17E-40,2.20E-37,72,451/43037 genes: 1.05%,ANAPC7|ATG7|ATM|BAG1|BAG2|BAG3|CAMK2A|CAMK2B|CAMK2G|CAT|CCNE1|CCNE2|CDC23|CDC26|CDK2|CDK6|CDKN1A|CEBPB|CHMP4C|CUL2|CYCS|DNAJB1|E2F1|EED|EGLN3|ERF|EZH2|FOS|FZR1|GPX1|GPX3|GPX6|H2AFZ|HSPA14|HSPA1A|HSPA9|IL6|JUN|LMNB1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MDM2|MDM4|MTOR|NCF4|NFKB1|NUP133|NUP214|PRDX2|PRDX6|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|RB1|SOD1|SOD2|TFDP2|TP53|TSC1|TSC2|TXN2|UBE2C|VCP|VEGFA|VHL|WIPI2,
Signaling by GPCR,REACT:R-HSA-372790,2.37E-38,4.44E-35,117,1341/43037 genes: 3.12%,ADRA2B|ADRB1|ADRB2|AGT|AKT2|ANXA1|APP|ARAF|ARHGEF5|ARHGEF6|ARRB2|AVPR1B|CALM2|CAMK2A|CAMK2B|CAMK2G|CCKBR|CCL1|CGA|CHRM1|CHRM2|CHRM4|CHRM5|CORT|CREB1|CRH|CRHBP|DGKI|DRD3|DRD4|DUSP1|ECE1|ECT2|EGFR|ERBB3|F2|FGB|FGD1|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FSHB|FYN|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|GCG|GFRA1|GNRH1|GNRHR|GPR17|GRIN1|GRIN2B|GRIN2C|GRK2|GRM5|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|IQGAP1|ITGA2B|KIT|LHB|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NET1|NPY|NTS|PDGFA|PDGFRA|PDGFRB|PENK|PIK3R2|PLCB1|POMC|PPP2R1A|PPP3R1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|PTCH2|PTH2|RAF1|RAP1A|RET|RGS18|RGS2|SRC|SSTR3|TAC1|VIPR2|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
HTLV-I infection,KEGG:hsa05166,2.40E-38,4.50E-35,55,256/43037 genes: 0.59%,AKT2|ANAPC7|ATF1|ATF2|ATM|BAX|BCL2L1|CALR|CCNB2|CCND1|CD3G|CDC20|CDC23|CDC26|CDKN1A|CHEK2|CREB1|E2F1|ELK1|FOS|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|IL6|JUN|MYB|MYC|NFKB1|PCNA|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP3R1|PTTG1|RB1|TGFB1|TGFB3|TNF|TNFRSF1A|TP53|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B|ZFP36,
NGF signalling via TRKA from the plasma membrane,REACT:R-HSA-187037,3.57E-38,6.69E-35,65,387/43037 genes: 0.90%,AKT2|ARAF|ARRB2|ATF1|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|CRK|DUSP1|EGFR|ELK1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MDM2|MET|MTOR|NEFL|NGF|NTRK1|NTRK2|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
Gastrin-CREB signalling pathway via PKC and MAPK,REACT:R-HSA-881907,2.48E-37,4.66E-34,68,443/43037 genes: 1.03%,AGT|ANXA1|APP|ARAF|ARRB2|AVPR1B|CALM2|CAMK2A|CAMK2B|CAMK2G|CCKBR|CHRM1|CHRM5|CREB1|DGKI|DUSP1|EGFR|ERBB3|F2|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GCG|GFRA1|GNRH1|GNRHR|GPR17|GRIN1|GRIN2B|GRIN2C|GRK2|GRM5|HTR2B|HTR2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NTS|PDGFA|PDGFRA|PDGFRB|PIK3R2|PLCB1|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|RGS18|RGS2|SRC|TAC1,
Rap1 signaling pathway,KEGG:hsa04015,2.75E-37,5.16E-34,50,210/43037 genes: 0.49%,ACTB|AKT2|CALM2|CRK|EGFR|EPHA2|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FGFR4|FLT4|GRIN1|GRIN2B|IGF1|INS|ITGA2B|KDR|KIT|MAP2K1|MAP2K2|MAP2K6|MAPK1|MAPK12|MAPK13|MAPK3|MET|NGF|PARD6A|PARD6B|PDGFA|PDGFC|PDGFRA|PDGFRB|PGF|PIK3R2|PLCB1|RAF1|RAP1A|SIPA1|SIPA1L1|SKAP1|SRC|VEGFA|VEGFB|VEGFC,
Platinum drug resistance,KEGG:hsa01524,3.28E-37,6.15E-34,34,73/43037 genes: 0.17%,ABCC2|AKT2|APAF1|ATM|BAK1|BAX|BBC3|BCL2|BCL2L1|BID|BIRC2|BIRC3|BIRC5|BRCA1|CASP3|CASP8|CASP9|CDKN1A|CYCS|FADD|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MAPK1|MAPK3|MDM2|MGST1|MGST2|MSH2|MSH6|PIK3R2|TP53,
Fc epsilon receptor (FCERI) signaling,REACT:R-HSA-2454202,8.01E-37,1.50E-33,63,378/43037 genes: 0.88%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDC34|CDKN1A|CREB1|CUL1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INS|IQGAP1|ITGA2B|JUN|KIT|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK10|MAPK3|MDM2|MET|MTOR|NEFL|NFKB1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PPP3R1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
FoxO signaling pathway,KEGG:hsa04068,5.98E-36,1.12E-32,41,132/43037 genes: 0.31%,AKT2|ARAF|ATM|BCL2L11|BCL6|BNIP3|CAT|CCNB1|CCNB2|CCND1|CDK2|CDKN1A|CSNK1E|EGFR|FOXO3|GADD45A|GADD45G|IGF1|IL10|IL6|INS|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MDM2|PIK3R2|PLK1|PLK2|PLK4|PRKAB1|PRMT1|RAF1|RBL2|SGK1|SOD2|TGFB1|TGFB3,
Signaling by VEGF,REACT:R-HSA-194138,1.05E-35,1.97E-32,59,338/43037 genes: 0.79%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FLT4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KDR|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MET|MTOR|NCF4|NEFL|PDGFA|PDGFRA|PDGFRB|PGF|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|VEGFA|VEGFB|VEGFC|WASF2,
Adaptive Immune System,REACT:R-HSA-1280218,1.11E-35,2.09E-32,88,818/43037 genes: 1.90%,AKT2|ANAPC7|AP1M2|ASB16|ASB3|ASB6|ATG7|CALM2|CALR|CASP9|CCNF|CD3G|CDC20|CDC23|CDC26|CDC34|CDKN1A|CENPE|CREB1|CTSB|CTSD|CUL1|CUL2|CUL5|DCTN2|EGFR|ERBB3|FBXO2|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|FZR1|HERC2|IFITM1|INPP5D|INS|ITGB7|KEAP1|KIF20A|KIF23|KIT|LGMN|LRSAM1|MAPK1|MAPK3|MDM2|MET|MTOR|MYD88|NCF4|NFKB1|PDGFA|PDGFRA|PDGFRB|PDIA3|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RACGAP1|RAF1|RAP1A|RIPK2|RNF34|SEC22B|SIPA1|SNAP23|SRC|TP53|TRAIP|TRIB3|TRIP12|TRPC1|TSC2|UBE2C|UBE2R2|VAMP8|VHL|XDH|ZBTB16,
Metabolism of proteins,REACT:R-HSA-392499,1.57E-35,2.95E-32,125,1623/43037 genes: 3.77%,ACTB|ACTR5|ADRB2|AGT|ANK1|APOA1|APP|AR|ARFGAP2|ARRB2|ARSB|ATP5F1A|ATP5F1B|AURKA|AURKB|AXIN2|B3GNT3|BABAM2|BIRC2|BIRC3|BIRC5|BRCA1|C1GALT1C1|CALM2|CALR|CCNE1|CCNE2|CDC20|CDC34|CDCA8|CETN2|CGA|COG1|COPB1|COQ2|COX17|CPB1|CSNK1D|CTSD|DAD1|DCTN2|DDIT3|DERL2|DNAJB9|DNAJC3|DOLK|DOLPP1|EIF4G1|ESR1|F2|FSHB|GCG|GFER|GH1|GRIA1|H2AFZ|HERC2|HSP90B1|HSPA9|IGF1|INS|ITM2B|KEAP1|LDHD|LHB|LMAN2|MAN2A1|MCRS1|MDC1|MDM2|MDM4|MPI|MYC|NEDD8|NFYC|NUP133|NUP214|PAM16|PARP1|PCNA|PDIA3|PIGC|PIGS|PLG|POMC|POMT1|PPP6R3|PRL|PRMT3|PSMA2|PSMA4|PSMC4|PSMD1|RABGGTB|RAD23B|RAE1|RIPK2|RPL6|RPS7|RPS8|SEC22B|SEC62|SLC17A5|SLC34A2|SMC1A|SNCA|SRP68|ST3GAL1|ST6GAL1|ST8SIA3|SYVN1|TGFB1|TOMM20|TP53|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9|UBA2|UBE2C|UBE2R2|UGGT2|USP16|VCP|ZBTB17,
Hepatitis B,KEGG:hsa05161,1.63E-35,3.06E-32,42,144/43037 genes: 0.33%,AKT2|APAF1|ATF2|BAX|BCL2|BIRC5|CASP12|CASP3|CASP8|CASP9|CCND1|CCNE1|CCNE2|CDK2|CDK6|CDKN1A|CREB1|CYCS|E2F1|ELK1|FADD|FOS|IL6|JUN|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MMP9|MYC|MYD88|NFKB1|PCNA|PIK3R2|RAF1|RB1|SRC|TGFB1|TGFB3|TNF|TP53,
Diseases of signal transduction,REACT:R-HSA-5663202,2.10E-35,3.93E-32,61,370/43037 genes: 0.86%,ADAM17|AKT2|ARAF|ARRB2|ATG7|BCL2L11|CASP9|CDKN1A|CREB1|CUL1|DERL2|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FXR1|FYN|FZD6|FZD8|GTF2F1|HDAC8|IQGAP1|ITGA2B|JAG1|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|MYC|NAPEPLD|NOTCH1|PDGFA|PDGFRA|PDGFRB|PIK3R2|POLR2B|POLR2F|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|SRC|SYVN1|TGFB1|TSC2|VCP|WNT3A,
Neuroactive ligand-receptor interaction,KEGG:hsa04080,2.39E-35,4.49E-32,54,277/43037 genes: 0.64%,ADRA2B|ADRB1|ADRB2|AVPR1B|CCKBR|CGA|CHRM1|CHRM2|CHRM4|CHRM5|CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4|DRD3|DRD4|F2|FSHB|GABRA1|GABRA2|GABRB2|GABRB3|GABRG1|GABRG2|GABRR1|GH1|GNRHR|GRIA1|GRIA2|GRID1|GRIK3|GRIN1|GRIN2B|GRIN2C|GRIN3B|GRM5|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|LHB|P2RX3|P2RX4|P2RX7|PLG|PRL|SSTR3|THRB|VIPR2,
Developmental Biology,REACT:R-HSA-1266738,2.41E-34,4.51E-31,99,1076/43037 genes: 2.50%,ACTB|ACVR1C|AKT2|ANK1|ARAF|ARRB2|ASH2L|BOC|CALM2|CAMK2A|CAMK2B|CAMK2G|CDH2|CEBPB|CEBPD|CREB1|CTCF|DUSP1|EED|EGFR|EPHA2|EPHA3|EPHA8|ERBB3|EZH2|FES|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GAP43|GFRA1|GRIN1|GRIN2B|GRIN2C|H2AFZ|INS|IQGAP1|ITGA2B|JUN|KDR|KIT|LAMB1|LCE1F|LGI1|MAP2K1|MAP2K2|MAP2K6|MAPK1|MAPK12|MAPK3|MED17|MED28|MED30|MED6|MET|MMP9|MYF5|NEFL|NFKB1|NOTCH1|NR5A1|NR5A2|NTN1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PLXND1|POLR2B|POLR2F|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RARA|RARB|RARG|RET|RGMA|RXRA|SALL1|SCN2A|SLC2A2|SRC|TGFB1|TNF|TRPC1|UNC5B|VEGFA,
Signaling by PDGF,REACT:R-HSA-186797,5.09E-34,9.54E-31,60,376/43037 genes: 0.87%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|NEFL|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|PLG|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
Signaling by SCF-KIT,REACT:R-HSA-1433557,9.10E-34,1.71E-30,57,337/43037 genes: 0.78%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|DUSP1|EGFR|ERBB3|FES|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MMP9|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
Tuberculosis,KEGG:hsa05152,1.03E-33,1.93E-30,44,178/43037 genes: 0.41%,AKT2|APAF1|BAX|BCL2|BID|CALM2|CAMK2A|CAMK2B|CAMK2G|CARD9|CASP3|CASP8|CASP9|CEBPB|CREB1|CTSD|CYCS|FADD|HSPA9|IL10|IL10RB|IL18|IL1B|IL6|LAMP1|LSP1|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|NFYC|PPP3R1|RAF1|RIPK2|SRC|TCIRG1|TGFB1|TGFB3|TNF|TNFRSF1A|TRADD,
Downstream signal transduction,REACT:R-HSA-186763,1.06E-33,1.99E-30,58,352/43037 genes: 0.82%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
Amyotrophic lateral sclerosis (ALS),KEGG:hsa05014,1.51E-33,2.84E-30,28,51/43037 genes: 0.12%,APAF1|BAX|BCL2|BCL2L1|BID|CASP12|CASP3|CASP9|CAT|CYCS|DAXX|GPX1|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|MAP2K6|MAPK12|MAPK13|NEFH|NEFL|NEFM|PPP3R1|SOD1|TNF|TNFRSF1A|TP53,
p53 signaling pathway,KEGG:hsa04115,2.02E-33,3.79E-30,31,69/43037 genes: 0.16%,APAF1|ATM|BAX|BBC3|BID|CASP3|CASP8|CASP9|CCNB1|CCNB2|CCND1|CCNE1|CCNE2|CDK1|CDK2|CDK6|CDKN1A|CHEK2|CYCS|GADD45A|GADD45G|IGF1|MDM2|MDM4|PIDD1|RRM2|SESN1|STEAP3|TP53|TSC2|ZMAT3,
Transmembrane transport of small molecules,REACT:R-HSA-382551,5.60E-33,1.05E-29,77,676/43037 genes: 1.57%,ABCB1|ABCC1|ABCC2|ABCC4|ABCC8|ABCE1|ABCG2|ALB|ANO10|APOA1|AQP11|AQP9|ATP2A2|BEST1|CALM2|CAMK2A|CAMK2B|CAMK2G|DERL2|FGF21|GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|HK2|HMOX1|HTR3A|HTR3B|LCN2|MCOLN2|NIPAL3|NUP133|NUP214|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|RAF1|RHBG|SGK1|SLC12A3|SLC12A4|SLC13A3|SLC16A1|SLC16A2|SLC16A7|SLC16A8|SLC17A3|SLC17A5|SLC18A1|SLC18A2|SLC1A5|SLC22A1|SLC26A11|SLC26A4|SLC29A1|SLC2A2|SLC34A2|SLC38A1|SLC44A1|SLC44A4|SLC4A1|SLC5A6|SLC6A12|SLC6A2|SLC6A3|SLC7A11|SLC7A2|SLC7A8|SLCO1C1|STEAP3|TCIRG1|TRPC1|VCP,
Signaling by EGFR,REACT:R-HSA-177929,6.94E-33,1.30E-29,58,364/43037 genes: 0.85%,ADAM17|AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
Prostate cancer,KEGG:hsa05215,1.66E-32,3.11E-29,33,87/43037 genes: 0.20%,AKT2|AR|ARAF|BCL2|CASP9|CCND1|CCNE1|CCNE2|CDK2|CDKN1A|CREB1|E2F1|EGFR|FGFR1|HSP90B1|IGF1|INS|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MTOR|NFKB1|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|RAF1|RB1|TCF7|TP53,
DAP12 signaling,REACT:R-HSA-2424491,1.88E-32,3.53E-29,57,356/43037 genes: 0.83%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
VEGFA-VEGFR2 Pathway,REACT:R-HSA-4420097,2.80E-32,5.26E-29,55,330/43037 genes: 0.77%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KDR|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MET|MTOR|NCF4|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|VEGFA|WASF2,
Melanoma,KEGG:hsa05218,7.60E-32,1.42E-28,30,69/43037 genes: 0.16%,AKT2|ARAF|CCND1|CDK6|CDKN1A|E2F1|EGFR|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|IGF1|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|RAF1|RB1|TP53,
Insulin receptor signalling cascade,REACT:R-HSA-74751,1.15E-31,2.15E-28,52,297/43037 genes: 0.69%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|TSC1|TSC2,
IGF1R signaling cascade,REACT:R-HSA-2428924,1.36E-31,2.55E-28,52,298/43037 genes: 0.69%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IGF1|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|TSC1|TSC2,
IRS-related events triggered by IGF1R,REACT:R-HSA-2428928,1.36E-31,2.55E-28,52,298/43037 genes: 0.69%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IGF1|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|TSC1|TSC2,
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),REACT:R-HSA-2404192,1.62E-31,3.03E-28,52,299/43037 genes: 0.69%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IGF1|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|TSC1|TSC2,
DAP12 interactions,REACT:R-HSA-2172127,1.79E-31,3.36E-28,57,371/43037 genes: 0.86%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CASP9|CDKN1A|CREB1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|GRK2|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TP53|TRIB3|TSC2,
IRS-mediated signalling,REACT:R-HSA-112399,7.04E-31,1.32E-27,51,294/43037 genes: 0.68%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TRIB3|TSC1|TSC2,
Signaling by Insulin receptor,REACT:R-HSA-74752,7.24E-31,1.36E-27,53,322/43037 genes: 0.75%,AKT2|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|EIF4G1|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INS|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PRKAB1|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|TCIRG1|TRIB3|TSC1|TSC2,
Fluid shear stress and atherosclerosis,KEGG:hsa05418,1.07E-30,2.01E-27,38,142/43037 genes: 0.33%,ACTB|AKT2|BCL2|CALM2|DUSP1|FOS|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|HMOX1|HSP90B1|IL1B|ITGA2B|JUN|KDR|KEAP1|MAP2K6|MAP2K7|MAPK10|MAPK12|MAPK13|MGST1|MGST2|MMP9|NFKB1|NOX1|NPPC|PDGFA|PIK3R2|SQSTM1|SRC|TNF|TNFRSF1A|TP53|TXN2|VEGFA,
Signalling to ERKs,REACT:R-HSA-187687,3.55E-30,6.65E-27,48,263/43037 genes: 0.61%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Signalling to RAS,REACT:R-HSA-167044,1.08E-29,2.02E-26,47,256/43037 genes: 0.59%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Endocrine resistance,KEGG:hsa01522,1.26E-29,2.36E-26,32,95/43037 genes: 0.22%,AKT2|ARAF|BAX|BCL2|BIK|CCND1|CDKN1A|E2F1|EGFR|ESR1|ESR2|FOS|IGF1|JAG1|JUN|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MDM2|MMP9|MTOR|NOTCH1|NOTCH2|PIK3R2|RAF1|RB1|SRC|TP53,
ARMS-mediated activation,REACT:R-HSA-170984,3.28E-29,6.14E-26,46,249/43037 genes: 0.58%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
MAPK family signaling cascades,REACT:R-HSA-5683057,3.62E-29,6.79E-26,49,290/43037 genes: 0.67%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CDK1|DNAJB1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IL6|IQGAP1|ITGA2B|JUN|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MYC|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Prolonged ERK activation events,REACT:R-HSA-169893,5.66E-29,1.06E-25,46,252/43037 genes: 0.59%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
FCERI mediated MAPK activation,REACT:R-HSA-2871796,1.51E-28,2.83E-25,47,271/43037 genes: 0.63%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOS|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|JUN|KIT|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK10|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
VEGFR2 mediated cell proliferation,REACT:R-HSA-5218921,1.65E-28,3.09E-25,46,258/43037 genes: 0.60%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KDR|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC|VEGFA,
Signalling to p38 via RIT and RIN,REACT:R-HSA-187706,3.54E-28,6.64E-25,45,249/43037 genes: 0.58%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Frs2-mediated activation,REACT:R-HSA-170968,4.23E-28,7.93E-25,45,250/43037 genes: 0.58%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
MAPK1/MAPK3 signaling,REACT:R-HSA-5684996,5.05E-28,9.47E-25,45,251/43037 genes: 0.58%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CDK1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IL6|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Interleukin receptor SHC signaling,REACT:R-HSA-912526,1.02E-27,1.91E-24,45,255/43037 genes: 0.59%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INPP5D|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
GPCR ligand binding,REACT:R-HSA-500792,1.13E-27,2.12E-24,58,454/43037 genes: 1.05%,ADRA2B|ADRB1|ADRB2|AGT|ANXA1|APP|AVPR1B|CCKBR|CCL1|CGA|CHRM1|CHRM2|CHRM4|CHRM5|CORT|CRH|CRHBP|DRD3|DRD4|ECE1|F2|FSHB|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|GCG|GNRH1|GNRHR|GPR17|GRM5|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|LHB|NPY|NTS|PENK|POMC|PTCH2|PTH2|SSTR3|TAC1|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Metabolism of lipids and lipoproteins,REACT:R-HSA-556833,1.30E-27,2.43E-24,77,814/43037 genes: 1.89%,ABCC1|ACADS|ACLY|ACOT11|ACOX3|ACSF2|ACSL4|ACSL5|ACSM3|AGT|AHR|ALB|ALDH7A1|ALOX15|ALOX5|APOA1|APOB|APOE|ARSB|CERS5|CGA|CIDEA|CIDEC|COQ2|CPTP|CYP1A1|CYP1A2|CYP1B1|CYP8B1|DEGS1|ELOVL7|EPHX2|FGF21|FYN|GGPS1|GPX1|GPX4|HSD17B12|HSD3B1|INPP5D|INSIG2|LDLR|LHB|LPIN2|LTA4H|MED17|MED28|MED30|MED6|MSMO1|NFYC|NPC1|NPC2|OSBPL10|OSBPL7|PDSS1|PECR|PIK3R2|PLEKHA1|PLPP3|POMC|PON1|PPT1|PPT2|RXRA|SCARB1|SGPL1|SGPP1|SIN3A|SLC10A1|SLC44A1|SLC44A4|SMPD3|SPTLC1|STAR|TNFAIP8|TRIB3,
TNF signaling pathway,KEGG:hsa04668,1.30E-27,2.44E-24,32,108/43037 genes: 0.25%,AKT2|ATF2|BCL3|BIRC2|BIRC3|CASP3|CASP7|CASP8|CEBPB|CREB1|FADD|FOS|IL1B|IL6|JAG1|JUN|JUNB|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MMP9|NFKB1|PIK3R2|TNF|TNFRSF1A|TRADD|VEGFC,
"Interleukin-3, 5 and GM-CSF signaling",REACT:R-HSA-512988,1.51E-27,2.84E-24,46,271/43037 genes: 0.63%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INPP5D|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Apoptosis - multiple species,KEGG:hsa04215,1.98E-27,3.71E-24,21,33/43037 genes: 0.08%,APAF1|BAK1|BAX|BBC3|BCL2|BCL2L1|BCL2L11|BID|BIRC2|BIRC3|BIRC5|BIRC6|CASP3|CASP7|CASP8|CASP9|CYCS|DIABLO|FADD|MAPK10|TNFRSF1A,
Neurotrophin signaling pathway,KEGG:hsa04722,2.18E-27,4.09E-24,33,119/43037 genes: 0.28%,AKT2|BAX|BCL2|BEX3|CALM2|CAMK2A|CAMK2B|CAMK2G|CRK|FOXO3|IRAK3|JUN|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|NGF|NTF4|NTRK1|NTRK2|NTRK3|PIK3R2|PRKCD|PSEN1|RAF1|RAP1A|RIPK2|TP53,
Post-translational protein modification,REACT:R-HSA-597592,2.27E-27,4.27E-24,87,1037/43037 genes: 2.41%,ACTB|ACTR5|ADRB2|ANK1|AR|ARFGAP2|ARRB2|ARSB|AURKA|AURKB|AXIN2|B3GNT3|BABAM2|BIRC2|BIRC3|BIRC5|BRCA1|C1GALT1C1|CALM2|CALR|CDC20|CDC34|CDCA8|CETN2|CGA|COG1|COPB1|CSNK1D|DAD1|DCTN2|DERL2|DOLK|DOLPP1|ESR1|F2|GRIA1|HERC2|INS|KEAP1|LHB|LMAN2|MAN2A1|MCRS1|MDC1|MDM2|MDM4|MPI|MYC|NEDD8|NUP133|NUP214|PARP1|PCNA|PDIA3|PIGC|PIGS|POMT1|PPP6R3|PRMT3|PSMA2|PSMA4|PSMC4|PSMD1|RABGGTB|RAD23B|RAE1|RIPK2|SEC22B|SLC17A5|SMC1A|ST3GAL1|ST6GAL1|ST8SIA3|SYVN1|TGFB1|TOMM20|TP53|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9|UBA2|UBE2C|UBE2R2|UGGT2|USP16|VCP,
Melanogenesis,KEGG:hsa04916,2.54E-27,4.77E-24,31,101/43037 genes: 0.23%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|PLCB1|POMC|RAF1|TCF7|TYR|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Interleukin-2 signaling,REACT:R-HSA-451927,3.36E-27,6.31E-24,45,262/43037 genes: 0.61%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|INPP5D|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Oocyte meiosis,KEGG:hsa04114,9.55E-27,1.79E-23,33,124/43037 genes: 0.29%,ANAPC7|AR|AURKA|CALM2|CAMK2A|CAMK2B|CAMK2G|CCNB1|CCNB2|CCNE1|CCNE2|CDC20|CDC23|CDC25C|CDC26|CDK1|CDK2|CUL1|ESPL1|FBXO5|IGF1|INS|MAP2K1|MAPK1|MAPK12|MAPK3|MOS|PGR|PLK1|PPP2R1A|PPP3R1|PTTG1|SMC1A,
Axon guidance,REACT:R-HSA-422475,1.75E-26,3.27E-23,62,550/43037 genes: 1.28%,ACTB|ANK1|ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|DUSP1|EGFR|EPHA2|EPHA3|EPHA8|ERBB3|FES|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GAP43|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KDR|KIT|LAMB1|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MMP9|NEFL|NTN1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PLXND1|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|RGMA|SCN2A|SRC|TRPC1|UNC5B|VEGFA,
GRB2 events in EGFR signaling,REACT:R-HSA-179812,1.92E-26,3.60E-23,43,245/43037 genes: 0.57%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
RAF/MAP kinase cascade,REACT:R-HSA-5673001,1.92E-26,3.60E-23,43,245/43037 genes: 0.57%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
SHC1 events in EGFR signaling,REACT:R-HSA-180336,1.92E-26,3.60E-23,43,245/43037 genes: 0.57%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
SOS-mediated signalling,REACT:R-HSA-112412,1.92E-26,3.60E-23,43,245/43037 genes: 0.57%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
PI3K/AKT activation,REACT:R-HSA-198203,2.95E-26,5.53E-23,33,128/43037 genes: 0.30%,AKT2|CASP9|CDKN1A|CREB1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|NGF|NTRK1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC|TP53|TRIB3|TSC2,
Colorectal cancer,KEGG:hsa05210,3.47E-26,6.50E-23,25,60/43037 genes: 0.14%,AKT2|ARAF|AXIN2|BAX|BCL2|BIRC5|CASP3|CASP9|CCND1|CYCS|FOS|JUN|MAP2K1|MAPK1|MAPK10|MAPK3|MSH2|MSH6|MYC|PIK3R2|RAF1|TCF7|TGFB1|TGFB3|TP53,
Signaling pathways regulating pluripotency of stem cells,KEGG:hsa04550,3.49E-26,6.55E-23,34,139/43037 genes: 0.32%,ACVR1C|AKT2|AXIN2|FGF2|FGFR1|FGFR4|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|ID2|IGF1|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|MYC|MYF5|PIK3R2|RAF1|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Regulation of actin cytoskeleton,KEGG:hsa04810,6.22E-26,1.17E-22,40,212/43037 genes: 0.49%,ACTB|ACTN1|ARAF|ARHGEF6|CHRM1|CHRM2|CHRM4|CHRM5|CRK|EGFR|F2|FGD1|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FGFR4|INS|IQGAP1|ITGA2B|ITGB7|MAP2K1|MAP2K2|MAPK1|MAPK3|MOS|MYLK|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|RAF1|SCIN|SRC|WASF2,
Vesicle-mediated transport,REACT:R-HSA-5653656,6.32E-26,1.19E-22,67,659/43037 genes: 1.53%,ADRB2|AKT2|ALB|AMBP|ANK1|AP1M2|APOA1|APOB|APOE|APP|ARFGAP2|ARRB2|BIN1|CALM2|CALR|CD3G|CENPE|CHMP4C|CHRM2|COG1|COL1A1|COPB1|COPS6|CSNK1D|DCTN2|DNASE2|EGFR|GDI1|GJA1|GJB2|GRIA1|GRK2|HBA1|HBA2|HSP90B1|INS|KIF18B|KIF20A|KIF20B|KIF23|LDLR|LMAN2|MAN2A1|MON1B|NEDD8|PPP6R3|PRKAB1|RABEP1|RACGAP1|SCARB1|SEC22B|SLC18A3|SNAP23|SRC|TJP1|TPD52L1|TRAPPC11|TRAPPC13|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9|TSC1|TSC2|VAMP8|VPS37C|WNT5A,
Signaling by Leptin,REACT:R-HSA-2586552,7.42E-26,1.39E-22,43,253/43037 genes: 0.59%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Ras signaling pathway,KEGG:hsa04014,8.92E-26,1.67E-22,41,227/43037 genes: 0.53%,AKT2|BCL2L1|CALM2|EGFR|ELK1|EPHA2|FGF1|FGF12|FGF17|FGF2|FGF21|FGF22|FGF9|FGFR1|FGFR4|FLT4|GRIN1|GRIN2B|IGF1|INS|KDR|KIT|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MET|NFKB1|NGF|PDGFA|PDGFC|PDGFRA|PDGFRB|PGF|PIK3R2|RAF1|RAP1A|VEGFA|VEGFB|VEGFC,
Mitotic G1-G1/S phases,REACT:R-HSA-453279,9.66E-26,1.81E-22,34,143/43037 genes: 0.33%,AKT2|CCNB1|CCND1|CCNE1|CCNE2|CCNH|CDC6|CDC7|CDK1|CDK2|CDK6|CDKN1A|CDKN1C|CUL1|DHFR|E2F1|E2F5|FBXO5|LIN9|MCM2|MYC|ORC4|ORC5|PCNA|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RB1|RBL2|RRM2|TFDP2|WEE1,
Hippo signaling pathway,KEGG:hsa04390,9.67E-26,1.81E-22,35,154/43037 genes: 0.36%,ACTB|AXIN2|BBC3|BIRC2|BIRC5|CCND1|CSNK1D|CSNK1E|FGF1|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|ID2|MYC|PARD6A|PARD6B|PPP2R1A|SAV1|STK3|TCF7|TGFB1|TGFB3|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
MicroRNAs in cancer,KEGG:hsa05206,1.18E-25,2.22E-22,46,299/43037 genes: 0.69%,ABCB1|ABCC1|ATM|BAK1|BCL2|BCL2L11|BRCA1|CASP3|CCND1|CCNE1|CCNE2|CDC25B|CDC25C|CDK6|CDKN1A|CRK|CYP1B1|DDIT4|E2F1|EGFR|ERBB3|EZH2|FZD3|HMOX1|KIF23|MAP2K1|MAP2K2|MAPK1|MDM2|MDM4|MET|MMP9|MTOR|MYC|NFKB1|NOTCH1|NOTCH2|PDGFA|PDGFRA|PDGFRB|PIK3R2|RAF1|TIMP3|TP53|VEGFA|WNT3A,
RET signaling,REACT:R-HSA-8853659,1.20E-25,2.25E-22,44,270/43037 genes: 0.63%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Transmission across Chemical Synapses,REACT:R-HSA-112315,1.57E-25,2.95E-22,40,217/43037 genes: 0.50%,CALM2|CAMK2A|CAMK2B|CAMK2G|CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4|COMT|CREB1|GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|GAD2|GRIA1|GRIA2|GRIK3|GRIN1|GRIN2B|GRIN2C|MAPK1|MDM2|NEFL|PLCB1|RAF1|SLC18A2|SLC18A3|SLC22A1|SLC38A1|SLC6A12|SLC6A3|SLC6A4|SNAP25|STXBP1,
EGFR tyrosine kinase inhibitor resistance,KEGG:hsa01521,2.09E-25,3.93E-22,27,79/43037 genes: 0.18%,AKT2|ARAF|BAX|BCL2|BCL2L1|BCL2L11|EGFR|ERBB3|FGF2|FOXO3|IGF1|IL6|KDR|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|RAF1|SRC|VEGFA,
Glioma,KEGG:hsa05214,2.47E-25,4.63E-22,25,64/43037 genes: 0.15%,AKT2|ARAF|CALM2|CAMK2A|CAMK2B|CAMK2G|CCND1|CDK6|CDKN1A|E2F1|EGFR|IGF1|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MTOR|PDGFA|PDGFRA|PDGFRB|PIK3R2|RAF1|RB1|TP53,
NCAM signaling for neurite out-growth,REACT:R-HSA-375165,3.04E-25,5.70E-22,44,276/43037 genes: 0.64%,ARAF|ARRB2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|DUSP1|EGFR|ERBB3|FGB|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|GFRA1|GRIN1|GRIN2B|GRIN2C|IQGAP1|ITGA2B|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|NEFL|PDGFA|PDGFRA|PDGFRB|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RAF1|RAP1A|RET|SRC,
Alzheimer's disease,KEGG:hsa05010,3.34E-25,6.26E-22,36,171/43037 genes: 0.40%,ADAM17|APAF1|APBB1|APOE|APP|ATP2A2|ATP5F1A|ATP5F1B|ATP6|BACE2|BID|CALM2|CASP12|CASP3|CASP7|CASP8|CASP9|CYCS|FADD|GAPDH|GRIN1|GRIN2B|GRIN2C|IL1B|MAPK1|MAPK3|MAPT|NDUFA12|PLCB1|PPP3R1|PSEN1|RTN4|SNCA|TNF|TNFRSF1A|UQCRH,
Hemostasis,REACT:R-HSA-109582,3.41E-25,6.39E-22,65,639/43037 genes: 1.48%,ABCC4|ACTN1|ADRA2B|AKT2|ALB|APOA1|APOB|APP|ARRB2|ATP2A2|C1QBP|CABLES1|CALM2|CDC37L1|CDK2|CENPE|CRK|DGKI|EPCAM|F2|FGB|FYN|IGF1|INPP5D|ITGA2B|KIF18B|KIF20A|KIF20B|KIF23|MAFK|MAPK1|MAPK3|MERTK|MYB|P2RX3|P2RX4|P2RX7|PDGFA|PIK3R2|PLG|PPP2R1A|PRKCD|RACGAP1|RAF1|RAP1A|S100A10|SERPINC1|SERPING1|SIN3A|SLC16A1|SLC16A8|SLC7A11|SLC7A8|SOD1|SRC|STXBP2|SYTL4|TGFB1|TGFB3|TIMP3|TP53|VEGFA|VEGFB|VEGFC|WEE1,
Focal adhesion,KEGG:hsa04510,6.71E-25,1.26E-21,38,199/43037 genes: 0.46%,ACTB|ACTN1|AKT2|BCL2|BIRC2|BIRC3|CCND1|COL1A1|CRK|EGFR|ELK1|FLT4|FYN|IGF1|ITGA2B|ITGB7|JUN|KDR|LAMA5|LAMB1|MAP2K1|MAPK1|MAPK10|MAPK3|MET|MYLK|PDGFA|PDGFC|PDGFRA|PDGFRB|PGF|PIK3R2|RAF1|RAP1A|SRC|VEGFA|VEGFB|VEGFC,
Programmed Cell Death,REACT:R-HSA-5357801,7.80E-25,1.46E-21,36,175/43037 genes: 0.41%,AKT2|APAF1|BAK1|BAX|BBC3|BCL2|BCL2L1|BCL2L11|BID|BIRC2|BIRC3|CASP3|CASP7|CASP8|CASP9|CYCS|DIABLO|E2F1|FADD|LMNB1|MAPT|NMT1|OCLN|OPA1|PPP1R13B|PPP3R1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|TFDP2|TJP1|TP53|TRADD|UNC5B,
Interleukin-4 and 13 signaling,REACT:R-HSA-6785807,2.79E-24,5.23E-21,30,114/43037 genes: 0.26%,ALOX15|ALOX5|ANXA1|BCL2|BCL2L1|BCL6|BIRC5|CCND1|CDKN1A|CEBPD|FGF2|FOS|FOXO3|HMOX1|HSP90B1|IL10|IL18|IL1B|IL6|JUNB|LAMA5|LCN2|MMP9|MYC|NDN|POMC|TGFB1|TNF|TP53|VEGFA,
PIP3 activates AKT signaling,REACT:R-HSA-1257604,3.44E-24,6.45E-21,31,125/43037 genes: 0.29%,AKT2|CASP9|CDKN1A|CREB1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC|TP53|TRIB3|TSC2,
Downstream signaling events of B Cell Receptor (BCR),REACT:R-HSA-1168372,5.16E-24,9.67E-21,37,197/43037 genes: 0.46%,AKT2|CASP9|CDKN1A|CREB1|CUL1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|NFKB1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|SRC|TP53|TRIB3|TSC2,
Apoptosis,REACT:R-HSA-109581,5.16E-24,9.67E-21,35,172/43037 genes: 0.40%,AKT2|APAF1|BAK1|BAX|BBC3|BCL2|BCL2L1|BCL2L11|BID|BIRC2|CASP3|CASP7|CASP8|CASP9|CYCS|DIABLO|E2F1|FADD|LMNB1|MAPT|NMT1|OCLN|OPA1|PPP1R13B|PPP3R1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|TFDP2|TJP1|TP53|TRADD|UNC5B,
GAB1 signalosome,REACT:R-HSA-180292,7.49E-24,1.40E-20,31,128/43037 genes: 0.30%,AKT2|CASP9|CDKN1A|CREB1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC|TP53|TRIB3|TSC2,
Intrinsic Pathway for Apoptosis,REACT:R-HSA-109606,8.98E-24,1.68E-20,21,44/43037 genes: 0.10%,AKT2|APAF1|BAK1|BAX|BBC3|BCL2|BCL2L1|BCL2L11|BID|CASP3|CASP7|CASP8|CASP9|CYCS|DIABLO|E2F1|NMT1|PPP1R13B|PPP3R1|TFDP2|TP53,
mTOR signaling pathway,KEGG:hsa04150,9.13E-24,1.71E-20,33,151/43037 genes: 0.35%,AKT2|DDIT4|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|IGF1|INS|MAP2K1|MAP2K2|MAPK1|MAPK3|MTOR|PIK3R2|RAF1|SGK1|TNF|TNFRSF1A|TSC1|TSC2|WDR24|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Cell Cycle Checkpoints,REACT:R-HSA-69620,1.08E-23,2.03E-20,37,201/43037 genes: 0.47%,ANAPC7|ATM|BABAM2|BRCA1|CCNB1|CCNB2|CCNE1|CCNE2|CDC20|CDC23|CDC25C|CDC26|CDC6|CDC7|CDK1|CDK2|CDKN1A|CHEK2|DNA2|HERC2|MCM2|MDC1|MDM2|MDM4|NSD2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RAD1|RFC4|TOPBP1|TP53|UBE2C|WEE1,
Central carbon metabolism in cancer,KEGG:hsa05230,1.13E-23,2.11E-20,24,65/43037 genes: 0.15%,AKT2|EGFR|FGFR1|G6PD|HK2|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|MTOR|MYC|NTRK1|NTRK3|PDGFRA|PDGFRB|PDK1|PIK3R2|RAF1|RET|SLC1A5|SLC2A2|TP53,
Wnt signaling pathway,KEGG:hsa04310,1.99E-23,3.73E-20,32,143/43037 genes: 0.33%,AXIN2|CAMK2A|CAMK2B|CAMK2G|CCND1|CSNK1E|CUL1|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|JUN|MAPK10|MYC|PLCB1|PPP3R1|PSEN1|SFRP2|TCF7|TP53|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Transcriptional misregulation in cancer,KEGG:hsa05202,2.11E-23,3.96E-20,35,179/43037 genes: 0.42%,AFF1|ATF1|ATM|BCL2L1|BCL6|BIRC3|CCNT1|CCNT2|CDK14|CDKN1A|CEBPB|DDIT3|ID2|IGF1|IL6|ITGB7|LDB1|MDM2|MEN1|MET|MMP9|MYC|MYCN|NFKB1|NSD2|NTRK1|PAX7|PDGFA|RARA|RXRA|SIN3A|TP53|WT1|ZBTB16|ZBTB17,
Signaling by the B Cell Receptor (BCR),REACT:R-HSA-983705,2.99E-23,5.61E-20,39,234/43037 genes: 0.54%,AKT2|CALM2|CASP9|CDKN1A|CREB1|CUL1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|NFKB1|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|SRC|TP53|TRIB3|TRPC1|TSC2,
cAMP signaling pathway,KEGG:hsa04024,6.74E-23,1.26E-19,36,198/43037 genes: 0.46%,ABCC4|ACOX3|ADRB1|ADRB2|AKT2|ATP2A2|CALM2|CAMK2A|CAMK2B|CAMK2G|CHRM1|CHRM2|CREB1|FOS|FSHB|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|GRIN3B|HTR1A|HTR1D|HTR6|JUN|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|NFKB1|NPY|PIK3R2|RAF1|RAP1A|VIPR2,
Role of LAT2/NTAL/LAB on calcium mobilization,REACT:R-HSA-2730905,6.81E-23,1.28E-19,31,137/43037 genes: 0.32%,AKT2|CASP9|CDKN1A|CREB1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|INS|KIT|MAPK1|MAPK3|MDM2|MET|MTOR|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC|TP53|TRIB3|TSC2,
Thyroid hormone signaling pathway,KEGG:hsa04919,7.96E-23,1.49E-19,29,116/43037 genes: 0.27%,ACTB|AKT2|ATP2A2|CASP9|CCND1|ESR1|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MED17|MED30|MTOR|MYC|NOTCH1|NOTCH2|PIK3R2|PLCB1|RAF1|RXRA|SIN3A|SLC16A2|SLCO1C1|SRC|THRB|TP53|TSC2|WNT4,
Neuronal System,REACT:R-HSA-112316,9.14E-23,1.71E-19,46,349/43037 genes: 0.81%,ABCC8|CALM2|CAMK2A|CAMK2B|CAMK2G|CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4|COMT|CREB1|FLOT1|GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|GAD2|GRIA1|GRIA2|GRIK3|GRIN1|GRIN2B|GRIN2C|GRM5|KCNB2|LRRTM3|MAPK1|MDM2|NEFL|PLCB1|RAF1|SIPA1L1|SLC18A2|SLC18A3|SLC22A1|SLC38A1|SLC6A12|SLC6A3|SLC6A4|SNAP25|STXBP1,
Sphingolipid signaling pathway,KEGG:hsa04071,1.35E-22,2.53E-19,29,118/43037 genes: 0.27%,ABCC1|AKT2|BAX|BCL2|BID|CERS5|CTSD|DEGS1|FYN|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|NSMAF|PIK3R2|PLCB1|PPP2R1A|RAF1|SGPL1|SGPP1|SPTLC1|TNF|TNFRSF1A|TP53|TRADD,
G1/S Transition,REACT:R-HSA-69206,1.75E-22,3.27E-19,29,119/43037 genes: 0.28%,AKT2|CCNB1|CCND1|CCNE1|CCNE2|CCNH|CDC6|CDC7|CDK1|CDK2|CDKN1A|CUL1|DHFR|E2F1|FBXO5|MCM2|MYC|ORC4|ORC5|PCNA|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RB1|RRM2|TFDP2|WEE1,
HIF-1 signaling pathway,KEGG:hsa04066,3.44E-22,6.46E-19,27,101/43037 genes: 0.23%,AKT2|BCL2|CAMK2A|CAMK2B|CAMK2G|CDKN1A|CUL2|EGFR|EGLN3|ENO1|GAPDH|HK2|HMOX1|IGF1|IL6|INS|MAP2K1|MAP2K2|MAPK1|MAPK3|MTOR|NFKB1|NOX1|PDK1|PIK3R2|VEGFA|VHL,
Toxoplasmosis,KEGG:hsa05145,5.69E-22,1.07E-18,28,113/43037 genes: 0.26%,AKT2|ALOX5|BCL2|BCL2L1|BIRC2|BIRC3|CASP3|CASP8|CASP9|CYCS|HSPA1A|IL10|IL10RB|LAMA5|LAMB1|LDLR|MAP2K6|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|TGFB1|TGFB3|TNF|TNFRSF1A,
Prolactin signaling pathway,KEGG:hsa04917,2.15E-21,4.04E-18,23,70/43037 genes: 0.16%,AKT2|CCND1|CGA|ESR1|ESR2|FOS|FOXO3|INS|LHB|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|PIK3R2|PRL|RAF1|SLC2A2|SRC|TH,
Basal cell carcinoma,KEGG:hsa05217,3.01E-21,5.64E-18,21,55/43037 genes: 0.13%,AXIN2|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|PTCH2|SUFU|TCF7|TP53|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Pancreatic cancer,KEGG:hsa05212,5.11E-21,9.58E-18,22,64/43037 genes: 0.15%,AKT2|ARAF|ARHGEF6|BCL2L1|BRCA2|CASP9|CCND1|CDK6|E2F1|EGFR|MAP2K1|MAPK1|MAPK10|MAPK3|NFKB1|PIK3R2|RAF1|RB1|TGFB1|TGFB3|TP53|VEGFA,
NOD-like receptor signaling pathway,KEGG:hsa04621,5.53E-21,1.04E-17,32,170/43037 genes: 0.40%,BCL2|BCL2L1|BIRC2|BIRC3|CARD9|CASP12|CASP4|CASP8|CTSB|ERBIN|FADD|IL18|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NAMPT|NFKB1|NOX1|P2RX7|PLCB1|PRKCD|PYCARD|RIPK2|SUGT1|TNF|TXN2,
Mitotic G2-G2/M phases,REACT:R-HSA-453274,6.56E-21,1.23E-17,33,184/43037 genes: 0.43%,AURKA|CCNB1|CCNB2|CCNH|CDC25B|CDC25C|CDK1|CDK2|CDKN1A|CENPF|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|CUL1|DCTN2|E2F1|HAUS1|HAUS8|HMMR|LIN9|PHLDA1|PLK1|PLK4|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|TP53|TUBGCP2|WEE1,
Serotonergic synapse,KEGG:hsa04726,6.78E-21,1.27E-17,27,112/43037 genes: 0.26%,ALOX15|ALOX5|APP|ARAF|CASP3|DUSP1|GABRB2|GABRB3|HTR1A|HTR1D|HTR2B|HTR2C|HTR3A|HTR3B|HTR5A|HTR6|MAP2K1|MAPK1|MAPK3|PLCB1|RAF1|SLC18A1|SLC18A2|SLC6A4|TPH1|TPH2|TRPC1,
GnRH signaling pathway,KEGG:hsa04912,7.68E-21,1.44E-17,25,92/43037 genes: 0.21%,CALM2|CAMK2A|CAMK2B|CAMK2G|CGA|EGFR|ELK1|FSHB|GNRH1|GNRHR|JUN|LHB|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|PLCB1|PRKCD|RAF1|SRC,
Small cell lung cancer,KEGG:hsa05222,1.24E-20,2.32E-17,24,84/43037 genes: 0.20%,AKT2|APAF1|BCL2|BCL2L1|BIRC2|BIRC3|CASP9|CCND1|CCNE1|CCNE2|CDK2|CDK6|CYCS|E2F1|ITGA2B|LAMA5|LAMB1|MYC|NFKB1|PIK3R2|RARB|RB1|RXRA|TP53,
Membrane Trafficking,REACT:R-HSA-199991,2.37E-20,4.44E-17,57,613/43037 genes: 1.42%,ADRB2|AKT2|ANK1|AP1M2|APOB|APP|ARFGAP2|ARRB2|BIN1|CALM2|CD3G|CENPE|CHMP4C|CHRM2|COG1|COPB1|COPS6|CSNK1D|DCTN2|DNASE2|EGFR|GDI1|GJA1|GJB2|GRIA1|GRK2|INS|KIF18B|KIF20A|KIF20B|KIF23|LDLR|LMAN2|MAN2A1|MON1B|NEDD8|PPP6R3|PRKAB1|RABEP1|RACGAP1|SEC22B|SLC18A3|SNAP23|SRC|TJP1|TPD52L1|TRAPPC11|TRAPPC13|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9|TSC1|TSC2|VAMP8|VPS37C|WNT5A,
Progesterone-mediated oocyte maturation,KEGG:hsa04914,2.42E-20,4.54E-17,25,96/43037 genes: 0.22%,AKT2|ANAPC7|ARAF|CCNB1|CCNB2|CDC23|CDC25B|CDC25C|CDC26|CDK1|CDK2|FZR1|IGF1|INS|MAP2K1|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MOS|PGR|PIK3R2|PLK1|RAF1,
G2/M Transition,REACT:R-HSA-69275,4.79E-20,8.97E-17,32,182/43037 genes: 0.42%,AURKA|CCNB1|CCNB2|CCNH|CDC25B|CDC25C|CDK1|CDK2|CDKN1A|CENPF|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|CUL1|DCTN2|HAUS1|HAUS8|HMMR|LIN9|PHLDA1|PLK1|PLK4|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|TP53|TUBGCP2|WEE1,
AGE-RAGE signaling pathway in diabetic complications,KEGG:hsa04933,5.52E-20,1.03E-16,25,99/43037 genes: 0.23%,AKT2|BAX|BCL2|CASP3|CCND1|COL1A1|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|NOX1|PIK3R2|PLCB1|PRKCD|TGFB1|TGFB3|TNF|VEGFA|VEGFB|VEGFC,
PI3K/AKT Signaling in Cancer,REACT:R-HSA-2219528,7.52E-20,1.41E-16,24,90/43037 genes: 0.21%,AKT2|CASP9|CDKN1A|CREB1|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FOXO3|FYN|KIT|MDM2|MET|MTOR|PDGFA|PDGFRA|PDGFRB|PIK3R2|TSC2,
Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell,REACT:R-HSA-112314,7.97E-20,1.49E-16,29,146/43037 genes: 0.34%,CALM2|CAMK2A|CAMK2B|CAMK2G|CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4|CREB1|GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|GRIA1|GRIA2|GRIK3|GRIN1|GRIN2B|GRIN2C|MAPK1|MDM2|NEFL|PLCB1|RAF1,
Legionellosis,KEGG:hsa05134,8.44E-20,1.58E-16,20,55/43037 genes: 0.13%,APAF1|BCL2L13|BNIP3|CASP3|CASP7|CASP8|CASP9|CLK1|CYCS|HSPA1A|IL18|IL1B|IL6|MYD88|NFKB1|PYCARD|SAR1A|SEC22B|TNF|VCP,
Influenza A,KEGG:hsa05164,1.03E-19,1.93E-16,31,173/43037 genes: 0.40%,ACTB|AKT2|ATF2|CASP9|CYCS|DDX39B|DNAJB1|DNAJC3|HSPA1A|IL18|IL1B|IL6|JUN|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|PIK3R2|PLG|PYCARD|RAE1|RAF1|TNF|TNFRSF1A,
TP53 Regulates Transcription of Cell Cycle Genes,REACT:R-HSA-6791312,1.66E-19,3.12E-16,19,49/43037 genes: 0.11%,AURKA|BAX|CCNB1|CCNE1|CCNE2|CDC25C|CDK1|CDK2|CDKN1A|E2F1|GADD45A|NPM1|PCNA|PLAGL1|PLK2|PRMT1|RBL2|TFDP2|TP53,
Cellular Senescence,REACT:R-HSA-2559583,4.81E-19,9.01E-16,32,196/43037 genes: 0.46%,ANAPC7|ATM|CCNE1|CCNE2|CDC23|CDC26|CDK2|CDK6|CDKN1A|CEBPB|E2F1|EED|ERF|EZH2|FOS|FZR1|H2AFZ|IL6|JUN|LMNB1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MDM2|MDM4|NFKB1|RB1|TFDP2|TP53|UBE2C,
Wnt signaling,KEGG:hsa_M00677,6.89E-19,1.29E-15,17,38/43037 genes: 0.09%,FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|TCF7|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Choline metabolism in cancer,KEGG:hsa05231,8.64E-19,1.62E-15,24,99/43037 genes: 0.23%,AKT2|DGKI|EGFR|FOS|JUN|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MTOR|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|PLPP3|RAF1|SLC22A1|SLC44A1|SLC44A4|TSC1|TSC2|WASF2,
Chronic myeloid leukemia,KEGG:hsa05220,1.42E-18,2.65E-15,21,71/43037 genes: 0.16%,AKT2|ARAF|BCL2L1|CCND1|CDK6|CDKN1A|CRK|E2F1|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MYC|NFKB1|PIK3R2|RAF1|RB1|TGFB1|TGFB3|TP53,
Chagas disease (American trypanosomiasis),KEGG:hsa05142,1.84E-18,3.44E-15,24,102/43037 genes: 0.24%,AKT2|CALR|CASP8|CD3G|FADD|FOS|IL10|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|PIK3R2|PLCB1|PPP2R1A|TGFB1|TGFB3|TNF|TNFRSF1A,
Signaling by Wnt,REACT:R-HSA-195721,2.29E-18,4.30E-15,40,336/43037 genes: 0.78%,AKT2|ARRB2|ASH2L|AXIN2|CALM2|CAMK2A|CSNK1E|CUL1|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|H2AFZ|MEN1|MYC|PARD6A|PLCB1|PPP2R1A|PPP3R1|PSMA2|PSMA4|PSMC4|PSMD1|RSPO3|SFRP2|SMARCA4|SOX6|TCF7|TLE1|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
SLC-mediated transmembrane transport,REACT:R-HSA-425407,2.69E-18,5.05E-15,37,286/43037 genes: 0.66%,ALB|CALM2|FGF21|HK2|NUP133|NUP214|RAE1|RHBG|SLC12A3|SLC12A4|SLC13A3|SLC16A1|SLC16A2|SLC16A7|SLC16A8|SLC17A5|SLC18A1|SLC18A2|SLC1A5|SLC22A1|SLC26A11|SLC26A4|SLC29A1|SLC2A2|SLC34A2|SLC38A1|SLC44A1|SLC44A4|SLC4A1|SLC5A6|SLC6A12|SLC6A2|SLC6A3|SLC7A11|SLC7A2|SLC7A8|SLCO1C1,
Protein processing in endoplasmic reticulum,KEGG:hsa04141,3.22E-18,6.04E-15,29,166/43037 genes: 0.39%,BAG1|BAG2|BAK1|BAX|BCL2|CALR|CASP12|CUL1|DAD1|DDIT3|DERL2|DNAJB1|DNAJC3|FBXO2|HSP90B1|HSPA1A|LMAN2|MAP2K7|MAPK10|NPLOC4|PDIA3|PDIA4|RAD23B|SAR1A|SEC62|SYVN1|UBXN6|UGGT2|VCP,
Toll-Like Receptors Cascades,REACT:R-HSA-168898,3.40E-18,6.38E-15,28,153/43037 genes: 0.36%,APOB|APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CTSB|CUL1|ELK1|FADD|FGB|FOS|HSP90B1|IRAK3|JUN|LGMN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Bladder cancer,KEGG:hsa05219,3.42E-18,6.41E-15,17,41/43037 genes: 0.10%,ARAF|CCND1|CDKN1A|E2F1|EGFR|MAP2K1|MAP2K2|MAPK1|MAPK3|MDM2|MMP9|MYC|RAF1|RB1|SRC|TP53|VEGFA,
Negative regulation of the PI3K/AKT network,REACT:R-HSA-199418,3.66E-18,6.86E-15,23,94/43037 genes: 0.22%,AKT2|EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|INS|KIT|MAPK1|MAPK3|MET|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC|TRIB3,
Calcium signaling pathway,KEGG:hsa04020,3.94E-18,7.39E-15,30,181/43037 genes: 0.42%,ADRB1|ADRB2|ATP2A2|AVPR1B|CALM2|CAMK2A|CAMK2B|CAMK2G|CCKBR|CHRM1|CHRM2|CHRM5|CHRNA7|EGFR|ERBB3|GRIN1|GRIN2C|GRM5|HTR2B|HTR2C|HTR5A|HTR6|MYLK|P2RX3|P2RX4|P2RX7|PDGFRA|PDGFRB|PLCB1|PPP3R1,
Osteoclast differentiation,KEGG:hsa04380,4.38E-18,8.21E-15,26,129/43037 genes: 0.30%,ACP5|AKT2|CREB1|FOS|FYN|IL1B|JUN|JUNB|JUND|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NCF4|NFKB1|NOX1|PIK3R2|PPP3R1|SQSTM1|TGFB1|TNF|TNFRSF1A,
M Phase,REACT:R-HSA-68886,4.81E-18,9.02E-15,38,308/43037 genes: 0.72%,ANAPC7|AURKB|BIRC5|CCNB1|CCNB2|CDC20|CDC23|CDC26|CDCA8|CDK1|CENPE|CENPF|CENPO|ESPL1|FBXO5|H2AFZ|HDAC8|KIF20A|KIF23|LMNB1|LPIN2|MAPK1|MAPK3|NDC80|NUF2|NUP133|NUP214|PLK1|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|RAE1|RB1|SMC1A|UBE2C,
S Phase,REACT:R-HSA-69242,5.36E-18,1.01E-14,26,130/43037 genes: 0.30%,CCND1|CCNE1|CCNE2|CCNH|CDC25B|CDC6|CDK2|CDKN1A|CUL1|DNA2|ESCO2|FZR1|LIG1|MCM2|MYC|ORC4|ORC5|PCNA|PSMA2|PSMA4|PSMC4|PSMD1|RB1|RFC4|SMC1A|WEE1,
ErbB signaling pathway,KEGG:hsa04012,6.93E-18,1.30E-14,22,86/43037 genes: 0.20%,AKT2|ARAF|CAMK2A|CAMK2B|CAMK2G|CDKN1A|CRK|EGFR|ELK1|ERBB3|JUN|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK10|MAPK3|MTOR|MYC|PIK3R2|RAF1|SRC,
Non-small cell lung cancer,KEGG:hsa05223,6.97E-18,1.31E-14,19,58/43037 genes: 0.13%,AKT2|ALK|ARAF|CASP9|CCND1|CDK6|E2F1|EGFR|FOXO3|MAP2K1|MAP2K2|MAPK1|MAPK3|PIK3R2|RAF1|RARB|RB1|RXRA|TP53,
DNA Repair,REACT:R-HSA-73894,1.15E-17,2.16E-14,38,316/43037 genes: 0.73%,ACTB|ACTR5|APBB1|ATM|BABAM2|BRCA1|BRCA2|CCNH|CDK2|CETN2|CHEK2|COPS6|DNA2|EYA2|FANCC|FANCG|HERC2|ISG15|KDM4B|LIG1|MCRS1|MDC1|MPG|MSH2|MSH6|NEIL1|NPLOC4|NSD2|PARP1|PCNA|POLR2B|POLR2F|RAD1|RAD23B|RFC4|TOPBP1|TP53|VCP,
"Platelet activation, signaling and aggregation",REACT:R-HSA-76002,1.19E-17,2.24E-14,36,282/43037 genes: 0.66%,ABCC4|ACTN1|ADRA2B|AKT2|ALB|APOA1|APP|ARRB2|CALM2|CDC37L1|CRK|DGKI|F2|FGB|FYN|IGF1|ITGA2B|MAPK1|MAPK3|PDGFA|PIK3R2|PLG|PRKCD|RAF1|RAP1A|SERPING1|SOD1|SRC|STXBP2|SYTL4|TGFB1|TGFB3|TIMP3|VEGFA|VEGFB|VEGFC,
Pertussis,KEGG:hsa05133,1.19E-16,2.24E-13,20,76/43037 genes: 0.18%,C1R|C1S|CALM2|CASP3|CASP7|FOS|IL10|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|PYCARD|SERPING1|TNF,
"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",REACT:R-HSA-6811558,1.42E-16,2.66E-13,21,87/43037 genes: 0.20%,EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|INS|KIT|MAPK1|MAPK3|MET|PDGFA|PDGFRA|PDGFRB|PIK3R2|PPP2R1A|SRC,
Long-term potentiation,KEGG:hsa04720,1.48E-16,2.78E-13,19,67/43037 genes: 0.16%,ARAF|CALM2|CAMK2A|CAMK2B|CAMK2G|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|GRM5|MAP2K1|MAP2K2|MAPK1|MAPK3|PLCB1|PPP3R1|RAF1|RAP1A,
MyD88-independent TLR3/TLR4 cascade,REACT:R-HSA-166166,1.79E-16,3.36E-13,22,99/43037 genes: 0.23%,APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CUL1|ELK1|FADD|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor 3 (TLR3) Cascade,REACT:R-HSA-168164,1.79E-16,3.36E-13,22,99/43037 genes: 0.23%,APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CUL1|ELK1|FADD|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
TRIF-mediated TLR3/TLR4 signaling,REACT:R-HSA-937061,1.79E-16,3.36E-13,22,99/43037 genes: 0.23%,APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CUL1|ELK1|FADD|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Endometrial cancer,KEGG:hsa05213,1.85E-16,3.47E-13,17,50/43037 genes: 0.12%,AKT2|ARAF|AXIN2|CASP9|CCND1|EGFR|ELK1|FOXO3|MAP2K1|MAP2K2|MAPK1|MAPK3|MYC|PIK3R2|RAF1|TCF7|TP53,
Amphetamine addiction,KEGG:hsa05031,2.02E-16,3.78E-13,19,68/43037 genes: 0.16%,ATF2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|FOS|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|GRIN3B|JUN|PPP3R1|SLC18A1|SLC18A2|SLC6A3|TH,
Activated TLR4 signalling,REACT:R-HSA-166054,4.40E-16,8.26E-13,23,115/43037 genes: 0.27%,APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CUL1|ELK1|FADD|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
G2/M Checkpoints,REACT:R-HSA-69481,4.83E-16,9.05E-13,27,169/43037 genes: 0.39%,ATM|BABAM2|BRCA1|CCNB1|CCNB2|CDC25C|CDC6|CDC7|CDK1|CDK2|CHEK2|DNA2|HERC2|MCM2|MDC1|NSD2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RAD1|RFC4|TOPBP1|TP53|WEE1,
Class B/2 (Secretin family receptors),REACT:R-HSA-373080,4.85E-16,9.09E-13,21,92/43037 genes: 0.21%,CRH|CRHBP|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|FZD9|GCG|PTCH2|PTH2|WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
IL-17 signaling pathway,KEGG:hsa04657,6.14E-16,1.15E-12,21,93/43037 genes: 0.22%,CASP3|CASP8|CEBPB|FADD|FOS|HSP90B1|IL1B|IL6|JUN|JUND|LCN2|MAPK1|MAPK10|MAPK12|MAPK13|MAPK15|MAPK3|MMP9|NFKB1|TNF|TRADD,
TP53 Regulates Transcription of Cell Death Genes,REACT:R-HSA-5633008,6.27E-16,1.18E-12,16,45/43037 genes: 0.10%,AIFM2|APAF1|ATM|BAX|BBC3|BCL2L14|BCL6|BID|BIRC5|BNIP3L|PIDD1|PPP1R13B|PRELID1|RABGGTB|STEAP3|TP53,
Dopaminergic synapse,KEGG:hsa04728,6.92E-16,1.30E-12,24,130/43037 genes: 0.30%,AKT2|ARRB2|ATF2|CALM2|CAMK2A|CAMK2B|CAMK2G|COMT|CREB1|DRD3|DRD4|FOS|GRIA1|GRIA2|GRIN2B|MAPK10|MAPK12|MAPK13|PLCB1|PPP2R1A|SLC18A1|SLC18A2|SLC6A3|TH,
Glutathione metabolism,KEGG:hsa00480,8.19E-16,1.54E-12,17,54/43037 genes: 0.13%,G6PD|GCLC|GPX1|GPX3|GPX4|GPX6|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MGST1|MGST2|ODC1|PGD|RRM2|TXNDC12,
Class A/1 (Rhodopsin-like receptors),REACT:R-HSA-373076,8.51E-16,1.59E-12,36,322/43037 genes: 0.75%,ADRA2B|ADRB1|ADRB2|AGT|ANXA1|APP|AVPR1B|CCKBR|CCL1|CGA|CHRM1|CHRM2|CHRM4|CHRM5|CORT|DRD3|DRD4|ECE1|F2|FSHB|GNRH1|GNRHR|GPR17|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|LHB|NPY|NTS|PENK|POMC|SSTR3|TAC1,
Renal cell carcinoma,KEGG:hsa05211,1.49E-15,2.79E-12,18,65/43037 genes: 0.15%,AKT2|ARAF|CRK|CUL2|EGLN3|JUN|MAP2K1|MAP2K2|MAPK1|MAPK3|MET|PIK3R2|RAF1|RAP1A|TGFB1|TGFB3|VEGFA|VHL,
Neutrophil degranulation,REACT:R-HSA-6798695,1.64E-15,3.07E-12,44,488/43037 genes: 1.13%,ACLY|ALOX5|APAF1|ARSB|ATAD3B|ATG7|CAND1|CAT|CDK13|CHRNB4|COPB1|CSTB|CTSB|CTSD|DEGS1|DNAJC3|FAF2|HSPA1A|IQGAP1|LAMP1|LCN2|LTA4H|MAN2B1|MAPK1|MGST1|MMP9|NFKB1|NPC2|PNP|PRDX6|PRKCD|PSEN1|PSMA2|PSMD1|PYCARD|QPCT|RAP1A|RNASET2|SNAP23|SNAP25|STBD1|TCIRG1|VAMP8|VCP,
Estrogen signaling pathway,KEGG:hsa04915,1.91E-15,3.58E-12,21,98/43037 genes: 0.23%,AKT2|ATF2|CALM2|CREB1|EGFR|ESR1|ESR2|FOS|HSP90B1|HSPA1A|JUN|MAP2K1|MAP2K2|MAPK1|MAPK3|MMP9|PIK3R2|PLCB1|PRKCD|RAF1|SRC,
Nicotine addiction,KEGG:hsa05033,2.01E-15,3.76E-12,15,40/43037 genes: 0.09%,CHRNA4|CHRNA7|GABRA1|GABRA2|GABRB2|GABRB3|GABRG1|GABRG2|GABRR1|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|GRIN3B,
"Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways",REACT:R-HSA-168643,2.06E-15,3.86E-12,16,48/43037 genes: 0.11%,APP|BCL2|BCL2L1|BIRC2|BIRC3|CARD9|CASP4|CASP8|CASP9|MAP2K6|MAPK12|MAPK13|P2RX7|PYCARD|RIPK2|SUGT1,
Ubiquitin mediated proteolysis,KEGG:hsa04120,2.39E-15,4.49E-12,24,137/43037 genes: 0.32%,ANAPC7|BIRC2|BIRC3|BIRC6|BRCA1|CDC20|CDC23|CDC26|CDC34|CUL1|CUL2|CUL5|FBXO2|FZR1|HERC2|KEAP1|MDM2|SYVN1|TRIP12|UBA2|UBE2C|UBE2R2|VHL|WWP2,
Gap junction,KEGG:hsa04540,2.64E-15,4.96E-12,20,88/43037 genes: 0.20%,ADRB1|CDK1|CSNK1D|EGFR|GJA1|GRM5|HTR2B|HTR2C|MAP2K1|MAP2K2|MAPK1|MAPK3|PDGFA|PDGFC|PDGFRA|PDGFRB|PLCB1|RAF1|SRC|TJP1,
Cholinergic synapse,KEGG:hsa04725,2.85E-15,5.35E-12,22,112/43037 genes: 0.26%,AKT2|BCL2|CAMK2A|CAMK2B|CAMK2G|CHRM1|CHRM2|CHRM4|CHRM5|CHRNA3|CHRNA4|CHRNA7|CHRNB4|CREB1|FOS|FYN|MAP2K1|MAPK1|MAPK3|PIK3R2|PLCB1|SLC18A3,
Toll Like Receptor 4 (TLR4) Cascade,REACT:R-HSA-166016,3.59E-15,6.74E-12,23,126/43037 genes: 0.29%,APP|ATF1|ATF2|BIRC2|BIRC3|CASP8|CREB1|CUL1|ELK1|FADD|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
E2F mediated regulation of DNA replication,REACT:R-HSA-113510,3.64E-15,6.83E-12,14,34/43037 genes: 0.08%,CCNB1|CCNE1|CDC6|CDK1|DHFR|E2F1|FBXO5|ORC4|ORC5|PCNA|PPP2R1A|RB1|RRM2|TFDP2,
Asparagine N-linked glycosylation,REACT:R-HSA-446203,4.40E-15,8.25E-12,33,284/43037 genes: 0.66%,ANK1|ARFGAP2|CALR|CGA|COG1|COPB1|CSNK1D|DAD1|DCTN2|DERL2|DOLK|DOLPP1|GRIA1|INS|LHB|LMAN2|MAN2A1|MPI|PDIA3|PPP6R3|RAD23B|SEC22B|SLC17A5|ST3GAL1|ST6GAL1|ST8SIA3|SYVN1|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9|UGGT2|VCP,
Epstein-Barr virus infection,KEGG:hsa05169,4.55E-15,8.54E-12,28,200/43037 genes: 0.46%,AKT2|ATF2|BCL2|CDK1|CDK2|CDKN1A|HSPA1A|IL10|IL10RB|JUN|MAP2K6|MAP2K7|MAPK10|MAPK12|MAPK13|MDM2|MYC|NFKB1|NUP214|PIK3R2|POLR2B|POLR2F|POLR3H|PSMC4|PSMD1|RB1|TP53|TRADD,
Autophagy - animal,KEGG:hsa04140,5.14E-15,9.63E-12,23,128/43037 genes: 0.30%,AKT2|ATG7|BCL2|BCL2L1|BNIP3|CTSB|CTSD|DDIT4|INS|LAMP1|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MTOR|PIK3R2|PRKCD|RAF1|TSC1|TSC2|VAMP8|WIPI2,
Viral carcinogenesis,KEGG:hsa05203,5.19E-15,9.72E-12,28,201/43037 genes: 0.47%,ACTN1|ATF2|BAK1|BAX|CASP3|CASP8|CCND1|CCNE1|CCNE2|CDC20|CDK1|CDK2|CDK6|CDKN1A|CREB1|HDAC8|JUN|MAPK1|MAPK3|MDM2|NFKB1|PIK3R2|RB1|RBL2|SCIN|SRC|TP53|TRADD,
Prion diseases,KEGG:hsa05020,5.95E-15,1.12E-11,14,35/43037 genes: 0.08%,BAX|C8B|CASP12|ELK1|FYN|HSPA1A|IL1B|IL6|MAP2K1|MAP2K2|MAPK1|MAPK3|NOTCH1|SOD1,
Amine ligand-binding receptors,REACT:R-HSA-375280,7.12E-15,1.34E-11,15,43/43037 genes: 0.10%,ADRA2B|ADRB1|ADRB2|CHRM1|CHRM2|CHRM4|CHRM5|DRD3|DRD4|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6,
Hepatitis C,KEGG:hsa05160,8.67E-15,1.63E-11,23,131/43037 genes: 0.30%,AKT2|ARAF|CDKN1A|CLDN2|CLDN7|EGFR|LDLR|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|OCLN|PIK3R2|PPP2R1A|RAF1|RXRA|SCARB1|TNF|TNFRSF1A|TP53|TRADD,
Thyroid cancer,KEGG:hsa05216,9.11E-15,1.71E-11,13,29/43037 genes: 0.07%,CCDC6|CCND1|MAP2K1|MAP2K2|MAPK1|MAPK3|MYC|NCOA4|NTRK1|RET|RXRA|TCF7|TP53,
Infectious disease,REACT:R-HSA-5663205,1.02E-14,1.91E-11,38,388/43037 genes: 0.90%,AP1M2|CALM2|CALR|CCNH|CCNT1|CCNT2|CHMP4C|CUL5|DNAJC3|FYN|GRSF1|GTF2F1|HSPA1A|ISG15|LIG1|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MET|NMT1|NPM1|NUP133|NUP214|POLR2B|POLR2F|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|RPL6|RPS7|RPS8|SNAP25|SRC|TGFB1|VPS37C,
Huntington's disease,KEGG:hsa05016,1.43E-14,2.68E-11,27,193/43037 genes: 0.45%,APAF1|ATP5F1A|ATP5F1B|ATP6|BAX|BBC3|CASP3|CASP8|CASP9|CREB1|CYCS|DCTN2|DNAL1|GPX1|GRIN1|GRIN2B|GRM5|NDUFA12|PLCB1|POLR2B|POLR2F|SIN3A|SOD1|SOD2|TGM2|TP53|UQCRH,
Mitotic Metaphase and Anaphase,REACT:R-HSA-2555396,2.02E-14,3.78E-11,26,180/43037 genes: 0.42%,ANAPC7|AURKB|BIRC5|CDC20|CDC23|CDC26|CDCA8|CENPE|CENPF|CENPO|ESPL1|FBXO5|HDAC8|LMNB1|NDC80|NUF2|NUP133|PLK1|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|SMC1A|UBE2C,
Acute myeloid leukemia,KEGG:hsa05221,2.36E-14,4.43E-11,16,55/43037 genes: 0.13%,AKT2|ARAF|CCND1|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MTOR|MYC|NFKB1|PIK3R2|RAF1|RARA|TCF7|ZBTB16,
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest,REACT:R-HSA-6804114,2.66E-14,4.99E-11,11,19/43037 genes: 0.04%,AURKA|BAX|CCNB1|CDC25C|CDK1|GADD45A|PCNA|PRMT1|RBL2|TFDP2|TP53,
APC/C-mediated degradation of cell cycle proteins,REACT:R-HSA-174143,2.87E-14,5.38E-11,19,87/43037 genes: 0.20%,ANAPC7|AURKA|AURKB|CCNB1|CDC20|CDC23|CDC26|CDK1|CDK2|CUL1|FBXO5|FZR1|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Regulation of mitotic cell cycle,REACT:R-HSA-453276,2.87E-14,5.38E-11,19,87/43037 genes: 0.20%,ANAPC7|AURKA|AURKB|CCNB1|CDC20|CDC23|CDC26|CDK1|CDK2|CUL1|FBXO5|FZR1|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Toll-like receptor signaling pathway,KEGG:hsa04620,7.96E-14,1.49E-10,20,104/43037 genes: 0.24%,AKT2|CASP8|FADD|FOS|IL1B|IL6|JUN|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|PIK3R2|TNF,
Class I MHC mediated antigen processing & presentation,REACT:R-HSA-983169,8.02E-14,1.50E-10,36,373/43037 genes: 0.87%,ANAPC7|ASB16|ASB3|ASB6|ATG7|CALR|CCNF|CDC20|CDC23|CDC26|CDC34|CUL1|CUL2|CUL5|FBXO2|FZR1|HERC2|KEAP1|LRSAM1|MYD88|NCF4|PDIA3|PSMA2|PSMA4|PSMC4|PSMD1|RNF34|SEC22B|SNAP23|TRAIP|TRIP12|UBE2C|UBE2R2|VAMP8|VHL|ZBTB16,
Axon guidance,KEGG:hsa04360,8.27E-14,1.55E-10,25,175/43037 genes: 0.41%,BOC|CAMK2A|CAMK2B|CAMK2G|EPHA2|EPHA3|EPHA8|FES|FYN|FZD3|MAPK1|MAPK3|MET|NTN1|PARD6A|PARD6B|PDK1|PIK3R2|PPP3R1|RAF1|SRC|TRPC1|UNC5B|WNT4|WNT5A,
Phospholipase D signaling pathway,KEGG:hsa04072,8.33E-14,1.56E-10,23,145/43037 genes: 0.34%,AKT2|AVPR1B|DGKI|EGFR|FYN|GRM5|INS|KIT|MAP2K1|MAP2K2|MAPK1|MAPK3|MTOR|PDGFA|PDGFC|PDGFRA|PDGFRB|PIK3R2|PLCB1|PLPP3|RAF1|TSC1|TSC2,
Platelet degranulation,REACT:R-HSA-114608,1.01E-13,1.89E-10,22,132/43037 genes: 0.31%,ABCC4|ACTN1|ALB|APOA1|APP|CALM2|CDC37L1|FGB|IGF1|ITGA2B|PDGFA|PLG|SERPING1|SOD1|STXBP2|SYTL4|TGFB1|TGFB3|TIMP3|VEGFA|VEGFB|VEGFC,
Regulation of TP53 Activity,REACT:R-HSA-5633007,1.14E-13,2.14E-10,24,162/43037 genes: 0.38%,AKT2|ATM|AURKA|AURKB|BRCA1|CDK1|CDK2|CHEK2|DAXX|DNA2|HIPK1|MAP2K6|MDM2|MDM4|MTOR|PPP1R13B|PPP2R1A|PRKAB1|RAD1|RFC4|RNF34|SGK1|TOPBP1|TP53,
Mitotic Anaphase,REACT:R-HSA-68882,1.40E-13,2.62E-10,25,179/43037 genes: 0.42%,ANAPC7|AURKB|BIRC5|CDC20|CDC23|CDC26|CDCA8|CENPE|CENPF|CENPO|ESPL1|HDAC8|LMNB1|NDC80|NUF2|NUP133|PLK1|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|SMC1A|UBE2C,
Non-alcoholic fatty liver disease (NAFLD),KEGG:hsa04932,1.51E-13,2.84E-10,23,149/43037 genes: 0.35%,AKT2|BAX|BCL2L11|BID|CASP3|CASP7|CASP8|CYCS|DDIT3|IL1B|IL6|INS|JUN|MAPK10|NDUFA12|NFKB1|PIK3R2|PRKAB1|RXRA|TGFB1|TNF|TNFRSF1A|UQCRH,
MyD88:Mal cascade initiated on plasma membrane,REACT:R-HSA-166058,1.57E-13,2.95E-10,19,95/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor 2 (TLR2) Cascade,REACT:R-HSA-181438,1.57E-13,2.95E-10,19,95/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor TLR1:TLR2 Cascade,REACT:R-HSA-168179,1.57E-13,2.95E-10,19,95/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor TLR6:TLR2 Cascade,REACT:R-HSA-168188,1.57E-13,2.95E-10,19,95/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|IRAK3|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Regulation of TP53 Degradation,REACT:R-HSA-6804757,1.76E-13,3.30E-10,13,35/43037 genes: 0.08%,AKT2|ATM|CDK1|CDK2|CHEK2|DAXX|MDM2|MDM4|MTOR|PPP2R1A|RNF34|SGK1|TP53,
Signaling by Rho GTPases,REACT:R-HSA-194315,1.82E-13,3.41E-10,38,425/43037 genes: 0.99%,ACTB|AR|ARHGEF5|ARHGEF6|AURKB|BIRC5|CALM2|CDC20|CDC25C|CDCA8|CENPE|CENPF|CENPO|CIT|ECT2|FGD1|GDI1|H2AFZ|IQGAP1|MAPK1|MAPK3|MEN1|MRTFA|MYLK|NCF4|NDC80|NET1|NOX1|NUF2|NUP133|PIK3R2|PLK1|PPP2R1A|PRC1|RACGAP1|SRC|TAX1BP3|WASF2,
MyD88 cascade initiated on plasma membrane,REACT:R-HSA-975871,1.94E-13,3.63E-10,18,84/43037 genes: 0.20%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor 10 (TLR10) Cascade,REACT:R-HSA-168142,1.94E-13,3.63E-10,18,84/43037 genes: 0.20%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor 5 (TLR5) Cascade,REACT:R-HSA-168176,1.94E-13,3.63E-10,18,84/43037 genes: 0.20%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Response to elevated platelet cytosolic Ca2+,REACT:R-HSA-76005,2.22E-13,4.17E-10,22,137/43037 genes: 0.32%,ABCC4|ACTN1|ALB|APOA1|APP|CALM2|CDC37L1|FGB|IGF1|ITGA2B|PDGFA|PLG|SERPING1|SOD1|STXBP2|SYTL4|TGFB1|TGFB3|TIMP3|VEGFA|VEGFB|VEGFC,
Separation of Sister Chromatids,REACT:R-HSA-2467813,2.59E-13,4.86E-10,24,168/43037 genes: 0.39%,ANAPC7|AURKB|BIRC5|CDC20|CDC23|CDC26|CDCA8|CENPE|CENPF|CENPO|ESPL1|HDAC8|NDC80|NUF2|NUP133|PLK1|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|SMC1A|UBE2C,
Regulation of TP53 Expression and Degradation,REACT:R-HSA-6806003,2.70E-13,5.06E-10,13,36/43037 genes: 0.08%,AKT2|ATM|CDK1|CDK2|CHEK2|DAXX|MDM2|MDM4|MTOR|PPP2R1A|RNF34|SGK1|TP53,
MAP kinase activation in TLR cascade,REACT:R-HSA-450294,3.24E-13,6.08E-10,16,64/43037 genes: 0.15%,ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|NFKB1|PPP2R1A|RIPK2,
Constitutive Signaling by Aberrant PI3K in Cancer,REACT:R-HSA-2219530,4.21E-13,7.90E-10,16,65/43037 genes: 0.15%,EGFR|ERBB3|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|FYN|KIT|MET|PDGFA|PDGFRA|PDGFRB|PIK3R2,
Cellular response to heat stress,REACT:R-HSA-3371556,5.59E-13,1.05E-09,18,89/43037 genes: 0.21%,ATM|BAG1|BAG2|BAG3|CAMK2A|CAMK2B|CAMK2G|DNAJB1|HSPA14|HSPA1A|HSPA9|MAPK1|MAPK3|MTOR|NUP133|NUP214|RAE1|VCP,
Fc epsilon RI signaling pathway,KEGG:hsa04664,7.02E-13,1.32E-09,16,67/43037 genes: 0.16%,AKT2|ALOX5|FYN|INPP5D|MAP2K1|MAP2K2|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|PIK3R2|RAF1|TNF,
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,REACT:R-HSA-975138,8.37E-13,1.57E-09,18,91/43037 genes: 0.21%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
TP53 Regulates Transcription of DNA Repair Genes,REACT:R-HSA-6796648,1.15E-12,2.15E-09,16,69/43037 genes: 0.16%,ATF2|ATM|BRCA1|CCNH|CCNT1|CCNT2|CDK13|FANCC|FOS|GTF2F1|JUN|MDC1|MSH2|POLR2B|POLR2F|TP53,
MyD88 dependent cascade initiated on endosome,REACT:R-HSA-975155,1.24E-12,2.32E-09,18,93/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Toll Like Receptor 7/8 (TLR7/8) Cascade,REACT:R-HSA-168181,1.24E-12,2.32E-09,18,93/43037 genes: 0.22%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
G0 and Early G1,REACT:R-HSA-1538133,1.39E-12,2.61E-09,11,25/43037 genes: 0.06%,CCNE1|CCNE2|CDC6|CDK1|CDK2|E2F1|E2F5|LIN9|PCNA|RBL2|TFDP2,
Cyclin A:Cdk2-associated events at S phase entry,REACT:R-HSA-69656,1.85E-12,3.46E-09,16,71/43037 genes: 0.16%,CCND1|CCNE1|CCNE2|CCNH|CDC25B|CDK2|CDKN1A|CUL1|FZR1|MYC|PSMA2|PSMA4|PSMC4|PSMD1|RB1|WEE1,
Activation of NMDA receptor upon glutamate binding and postsynaptic events,REACT:R-HSA-442755,1.87E-12,3.50E-09,13,41/43037 genes: 0.10%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|MAPK1|NEFL|RAF1,
Oxytocin signaling pathway,KEGG:hsa04921,1.94E-12,3.64E-09,22,152/43037 genes: 0.35%,ACTB|CALM2|CAMK2A|CAMK2B|CAMK2G|CCND1|CDKN1A|EGFR|ELK1|FOS|JUN|MAP2K1|MAP2K2|MAPK1|MAPK3|MYLK|PLCB1|PPP3R1|PRKAB1|RAF1|RGS2|SRC,
RHO GTPase Effectors,REACT:R-HSA-195258,2.30E-12,4.31E-09,30,294/43037 genes: 0.68%,ACTB|AR|AURKB|BIRC5|CALM2|CDC20|CDC25C|CDCA8|CENPE|CENPF|CENPO|CIT|H2AFZ|IQGAP1|MAPK1|MAPK3|MEN1|MRTFA|MYLK|NCF4|NDC80|NOX1|NUF2|NUP133|PLK1|PPP2R1A|PRC1|SRC|TAX1BP3|WASF2,
Signaling by BRAF and RAF fusions,REACT:R-HSA-6802952,2.32E-12,4.34E-09,15,61/43037 genes: 0.14%,ARAF|ARRB2|ATG7|BCL2L11|FGB|FXR1|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Inflammatory mediator regulation of TRP channels,KEGG:hsa04750,2.64E-12,4.95E-09,18,97/43037 genes: 0.23%,CALM2|CAMK2A|CAMK2B|CAMK2G|HTR2B|HTR2C|IGF1|IL1B|MAP2K6|MAPK10|MAPK12|MAPK13|NGF|NTRK1|PIK3R2|PLCB1|PRKCD|SRC,
Toll Like Receptor 9 (TLR9) Cascade,REACT:R-HSA-168138,2.64E-12,4.95E-09,18,97/43037 genes: 0.23%,APP|ATF1|ATF2|CREB1|CUL1|ELK1|FOS|JUN|MAP2K1|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MYD88|NFKB1|PPP2R1A|RIPK2,
Signaling by high-kinase activity BRAF mutants,REACT:R-HSA-6802948,4.62E-12,8.67E-09,12,35/43037 genes: 0.08%,ARAF|ARRB2|FGB|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
G alpha (q) signalling events,REACT:R-HSA-416476,4.93E-12,9.24E-09,24,192/43037 genes: 0.45%,AGT|ANXA1|APP|AVPR1B|CCKBR|CHRM1|CHRM5|DGKI|F2|GCG|GNRH1|GNRHR|GPR17|GRK2|GRM5|HTR2B|HTR2C|NTS|PIK3R2|PLCB1|PRKCD|RGS18|RGS2|TAC1,
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,REACT:R-HSA-6803204,5.53E-12,1.04E-08,10,21/43037 genes: 0.05%,AIFM2|ATM|BAX|BBC3|BID|BNIP3L|PPP1R13B|PRELID1|STEAP3|TP53,
Longevity regulating pathway,KEGG:hsa04211,6.53E-12,1.23E-08,17,89/43037 genes: 0.21%,AKT2|ATF2|BAX|CAT|CREB1|FOXO3|IGF1|INS|MTOR|NFKB1|PIK3R2|PRKAB1|SESN1|SOD2|TP53|TSC1|TSC2,
T cell receptor signaling pathway,KEGG:hsa04660,7.65E-12,1.43E-08,18,103/43037 genes: 0.24%,AKT2|CD3G|FOS|FYN|IL10|JUN|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK12|MAPK13|MAPK3|NFKB1|PIK3R2|PPP3R1|RAF1|TNF,
Cyclin A/B1 associated events during G2/M transition,REACT:R-HSA-69273,9.94E-12,1.86E-08,10,22/43037 genes: 0.05%,CCNB1|CCNB2|CCNH|CDC25B|CDC25C|CDK1|CDK2|PLK1|PPP2R1A|WEE1,
CREB phosphorylation through the activation of Ras,REACT:R-HSA-442742,1.00E-11,1.88E-08,11,29/43037 genes: 0.07%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|GRIN1|GRIN2B|GRIN2C|MAPK1|NEFL|RAF1,
TCF dependent signaling in response to WNT,REACT:R-HSA-201681,1.44E-11,2.70E-08,26,238/43037 genes: 0.55%,AKT2|ASH2L|AXIN2|CSNK1E|FZD1|FZD2|FZD6|FZD8|H2AFZ|MEN1|MYC|PPP2R1A|PSMA2|PSMA4|PSMC4|PSMD1|RSPO3|SFRP2|SMARCA4|SOX6|TCF7|TLE1|WNT3A|WNT4|WNT5A|WNT9A,
Metabolism of carbohydrates,REACT:R-HSA-71387,1.45E-11,2.72E-08,29,296/43037 genes: 0.69%,ARSB|B3GNT3|CALM2|CHIA|ENO1|FGF21|G6PD|GALE|GALK1|GAPDH|GYG2|HK2|HMMR|LCT|MAN2B1|NUP133|NUP214|PC|PGD|PPP2R1A|PRELP|PYGM|RAE1|RPIA|SI|SLC2A2|ST3GAL1|TPI1|UGP2,
Herpes simplex infection,KEGG:hsa05168,1.53E-11,2.87E-08,23,185/43037 genes: 0.43%,C1QBP|CASP3|CASP8|CDC34|CDK1|CDK2|CUL1|CYCS|DAXX|FADD|FOS|IL1B|IL6|JUN|MAPK10|MCRS1|MYD88|NFKB1|SRSF5|TNF|TNFRSF1A|TP53|UBE2R2,
Regulation of APC/C activators between G1/S and early anaphase,REACT:R-HSA-176408,1.59E-11,2.98E-08,16,81/43037 genes: 0.19%,ANAPC7|CCNB1|CDC20|CDC23|CDC26|CDK1|CDK2|CUL1|FBXO5|FZR1|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|UBE2C,
MAPK (ERK1/2) signaling,KEGG:hsa_M00687,1.59E-11,2.98E-08,7,8/43037 genes: 0.02%,ARAF|MAP2K1|MAP2K2|MAPK1|MAPK3|MOS|RAF1,
CREB phosphorylation through the activation of CaMKII,REACT:R-HSA-442729,1.91E-11,3.57E-08,9,17/43037 genes: 0.04%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|GRIN1|GRIN2B|GRIN2C|NEFL,
"Unblocking of NMDA receptor, glutamate binding and activation",REACT:R-HSA-438066,1.91E-11,3.57E-08,9,17/43037 genes: 0.04%,CAMK2A|CAMK2B|CAMK2G|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|NEFL,
Insulin signaling pathway,KEGG:hsa04910,1.91E-11,3.58E-08,20,138/43037 genes: 0.32%,AKT2|ARAF|CALM2|CRK|ELK1|FLOT1|HK2|INS|MAP2K1|MAP2K2|MAPK1|MAPK10|MAPK3|MTOR|PIK3R2|PRKAB1|PYGM|RAF1|TSC1|TSC2,
Metabolism of amino acids and derivatives,REACT:R-HSA-71291,1.98E-11,3.71E-08,32,362/43037 genes: 0.84%,AGXT2|AIMP1|AIMP2|ALDH7A1|BCAT1|CGA|DBH|EEF1E1|ENOPH1|GCLC|GPT|HIBADH|IARS|KYAT1|LIAS|NAGS|ODC1|PNMT|PSMA2|PSMA4|PSMC4|PSMD1|RPL6|RPS7|RPS8|SERINC3|SLC6A12|SLC6A8|TH|TPH1|TPH2|TYR,
Cyclin D associated events in G1,REACT:R-HSA-69231,2.00E-11,3.75E-08,12,39/43037 genes: 0.09%,CCND1|CCNH|CDK6|CDKN1A|CDKN1C|CUL1|E2F1|E2F5|PPP2R1A|RB1|RBL2|TFDP2,
G1 Phase,REACT:R-HSA-69236,2.00E-11,3.75E-08,12,39/43037 genes: 0.09%,CCND1|CCNH|CDK6|CDKN1A|CDKN1C|CUL1|E2F1|E2F5|PPP2R1A|RB1|RBL2|TFDP2,
MAP2K and MAPK activation,REACT:R-HSA-5674135,2.00E-11,3.75E-08,12,39/43037 genes: 0.09%,ARAF|ARRB2|FGB|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Paradoxical activation of RAF signaling by kinase inactive BRAF,REACT:R-HSA-6802955,2.00E-11,3.75E-08,12,39/43037 genes: 0.09%,ARAF|ARRB2|FGB|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Signaling by moderate kinase activity BRAF mutants,REACT:R-HSA-6802946,2.00E-11,3.75E-08,12,39/43037 genes: 0.09%,ARAF|ARRB2|FGB|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Biological oxidations,REACT:R-HSA-211859,2.01E-11,3.77E-08,25,223/43037 genes: 0.52%,AADAC|ADH5|AHR|CHAC1|COMT|CYP1A1|CYP1A2|CYP1B1|CYP26A1|CYP2B6|CYP3A4|CYP8B1|EPHX1|GCLC|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MARC1|MGST1|MGST2|POMC|RXRA|UGP2,
DNA Replication,REACT:R-HSA-69306,2.06E-11,3.86E-08,18,109/43037 genes: 0.25%,CDC6|CDC7|CDK2|CDKN1A|DNA2|E2F1|FZR1|LIG1|MCM2|ORC4|ORC5|PCNA|PSMA2|PSMA4|PSMC4|PSMD1|RB1|RFC4,
VEGF signaling pathway,KEGG:hsa04370,2.12E-11,3.97E-08,14,59/43037 genes: 0.14%,AKT2|CASP9|KDR|MAP2K1|MAP2K2|MAPK1|MAPK12|MAPK13|MAPK3|PIK3R2|PPP3R1|RAF1|SRC|VEGFA,
Deubiquitination,REACT:R-HSA-5688426,2.18E-11,4.10E-08,29,301/43037 genes: 0.70%,ACTB|ACTR5|ADRB2|AR|ARRB2|AXIN2|BABAM2|BIRC2|BIRC3|BRCA1|CDC20|ESR1|KEAP1|MCRS1|MDM2|MDM4|MYC|NEDD8|PSMA2|PSMA4|PSMC4|PSMD1|RAD23B|RIPK2|TGFB1|TOMM20|TP53|USP16|VCP,
Cocaine addiction,KEGG:hsa05030,2.37E-11,4.45E-08,13,49/43037 genes: 0.11%,ATF2|CREB1|GRIA2|GRIN1|GRIN2B|GRIN2C|GRIN3B|JUN|NFKB1|SLC18A1|SLC18A2|SLC6A3|TH,
Ferroptosis,KEGG:hsa04216,2.80E-11,5.26E-08,12,40/43037 genes: 0.09%,ACSL4|ACSL5|ALOX15|ATG7|GCLC|GPX4|HMOX1|NCOA4|PCBP2|SLC7A11|STEAP3|TP53,
Cyclin E associated events during G1/S transition,REACT:R-HSA-69202,3.05E-11,5.72E-08,15,72/43037 genes: 0.17%,AKT2|CCND1|CCNE1|CCNE2|CCNH|CDK2|CDKN1A|CUL1|MYC|PSMA2|PSMA4|PSMC4|PSMD1|RB1|WEE1,
Leishmaniasis,KEGG:hsa05140,3.05E-11,5.72E-08,15,72/43037 genes: 0.17%,ELK1|FOS|IL10|IL1B|JUN|MAPK1|MAPK12|MAPK13|MAPK3|MYD88|NCF4|NFKB1|TGFB1|TGFB3|TNF,
Ovarian steroidogenesis,KEGG:hsa04913,3.14E-11,5.90E-08,13,50/43037 genes: 0.12%,ALOX5|BMP15|CGA|CYP1A1|CYP1B1|FSHB|HSD3B1|IGF1|INS|LDLR|LHB|SCARB1|STAR,
G1/S-Specific Transcription,REACT:R-HSA-69205,3.74E-11,7.01E-08,9,18/43037 genes: 0.04%,CCNE1|CDC6|CDK1|DHFR|E2F1|FBXO5|PCNA|RRM2|TFDP2,
Salmonella infection,KEGG:hsa05132,4.13E-11,7.75E-08,16,86/43037 genes: 0.20%,ACTB|FOS|IL18|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MYD88|NFKB1|PYCARD|TJP1|WASF2,
Nuclear Receptor transcription pathway,REACT:R-HSA-383280,4.14E-11,7.76E-08,13,51/43037 genes: 0.12%,AR|ESR1|ESR2|NR1I2|NR1I3|NR5A1|NR5A2|PGR|RARA|RARB|RARG|RXRA|THRB,
Antigen processing: Ubiquitination & Proteasome degradation,REACT:R-HSA-983168,4.82E-11,9.04E-08,29,311/43037 genes: 0.72%,ANAPC7|ASB16|ASB3|ASB6|ATG7|CCNF|CDC20|CDC23|CDC26|CDC34|CUL1|CUL2|CUL5|FBXO2|FZR1|HERC2|KEAP1|LRSAM1|PSMA2|PSMA4|PSMC4|PSMD1|RNF34|TRAIP|TRIP12|UBE2C|UBE2R2|VHL|ZBTB16,
Retrograde endocannabinoid signaling,KEGG:hsa04723,5.42E-11,1.02E-07,17,101/43037 genes: 0.23%,GABRA1|GABRA2|GABRB2|GABRB3|GABRG1|GABRG2|GABRR1|GRIA1|GRIA2|GRM5|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NAPEPLD|PLCB1,
Oncogenic MAPK signaling,REACT:R-HSA-6802957,5.67E-11,1.06E-07,15,75/43037 genes: 0.17%,ARAF|ARRB2|ATG7|BCL2L11|FGB|FXR1|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Alcoholism,KEGG:hsa05034,5.91E-11,1.11E-07,22,180/43037 genes: 0.42%,ARAF|ATF2|CALM2|CREB1|CRH|GRIN1|GRIN2B|GRIN2C|GRIN3B|H2AFZ|HDAC8|MAP2K1|MAPK1|MAPK3|NPY|NTRK2|RAF1|SLC18A1|SLC18A2|SLC29A1|SLC6A3|TH,
Resolution of Sister Chromatid Cohesion,REACT:R-HSA-2500257,7.49E-11,1.40E-07,17,103/43037 genes: 0.24%,AURKB|BIRC5|CCNB1|CCNB2|CDC20|CDCA8|CDK1|CENPE|CENPF|CENPO|HDAC8|NDC80|NUF2|NUP133|PLK1|PPP2R1A|SMC1A,
Regulation of PLK1 Activity at G2/M Transition,REACT:R-HSA-2565942,8.48E-11,1.59E-07,16,90/43037 genes: 0.21%,AURKA|CCNB1|CCNB2|CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|CUL1|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A,
Organelle biogenesis and maintenance,REACT:R-HSA-1852241,8.78E-11,1.65E-07,30,340/43037 genes: 0.79%,ATF2|ATP5F1B|BBS4|BBS7|CDK1|CEP164|CEP70|CETN2|CREB1|CSNK1D|CSNK1E|CYCS|DAP3|DCTN2|ERAL1|HAUS1|HAUS8|MAPK12|MRPL19|MRPL2|MRPL23|MRPL54|PLK1|PLK4|PPP2R1A|PPRC1|PRKAB1|RXRA|SSTR3|TFB1M,
Phosphorylation of Emi1,REACT:R-HSA-176417,9.51E-11,1.78E-07,6,6/43037 genes: 0.01%,CCNB1|CDC20|CDK1|FBXO5|FZR1|PLK1,
Endocytosis,KEGG:hsa04144,1.04E-10,1.95E-07,26,260/43037 genes: 0.60%,ADRB1|ADRB2|ARFGAP2|ARRB2|BIN1|CHMP4C|EGFR|ERBB3|FGFR4|GRK2|HSPA1A|KDR|KIT|LDLR|MDM2|MET|NTRK1|PARD6A|PARD6B|PDGFRA|RABEP1|RET|SRC|TGFB1|TGFB3|VPS37C,
PI3K Cascade,REACT:R-HSA-109704,1.24E-10,2.32E-07,15,79/43037 genes: 0.18%,AKT2|EIF4G1|FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|MTOR|PIK3R2|PRKAB1|TRIB3|TSC1|TSC2,
Th17 cell differentiation,KEGG:hsa04659,1.40E-10,2.62E-07,17,107/43037 genes: 0.25%,AHR|CD3G|FOS|IL1B|IL6|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|MTOR|NFKB1|PPP3R1|RARA|RXRA|TGFB1,
G2/M DNA damage checkpoint,REACT:R-HSA-69473,1.97E-10,3.70E-07,16,95/43037 genes: 0.22%,ATM|BABAM2|BRCA1|CCNB1|CDC25C|CDK1|CHEK2|DNA2|HERC2|MDC1|NSD2|RAD1|RFC4|TOPBP1|TP53|WEE1,
Metabolism of vitamins and cofactors,REACT:R-HSA-196854,2.04E-10,3.82E-07,21,174/43037 genes: 0.40%,ABCC1|ACP5|APOA1|APOB|APOE|COASY|CTRC|CYP8B1|DHFR|GSTO1|GSTO2|LDLR|LGMN|LMBRD1|MMADHC|NAMPT|PARP4|PC|SLC19A2|SLC5A6|UBIAD1,
Post NMDA receptor activation events,REACT:R-HSA-438064,2.12E-10,3.97E-07,11,37/43037 genes: 0.09%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|GRIN1|GRIN2B|GRIN2C|MAPK1|NEFL|RAF1,
Chemical carcinogenesis,KEGG:hsa05204,2.16E-10,4.04E-07,15,82/43037 genes: 0.19%,ADH5|CHRNA7|CYP1A1|CYP1A2|CYP1B1|CYP3A4|EPHX1|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|KYAT1|MGST1|MGST2,
SUMOylation,REACT:R-HSA-2990846,2.19E-10,4.10E-07,17,110/43037 genes: 0.26%,AURKA|AURKB|BIRC5|BRCA1|CDCA8|CETN2|HERC2|MDC1|MDM2|NUP133|NUP214|PARP1|PCNA|RAE1|SMC1A|TP53|UBA2,
Mitotic Prometaphase,REACT:R-HSA-68877,2.53E-10,4.75E-07,17,111/43037 genes: 0.26%,AURKB|BIRC5|CCNB1|CCNB2|CDC20|CDCA8|CDK1|CENPE|CENPF|CENPO|HDAC8|NDC80|NUF2|NUP133|PLK1|PPP2R1A|SMC1A,
Detoxification of Reactive Oxygen Species,REACT:R-HSA-3299685,2.92E-10,5.47E-07,11,38/43037 genes: 0.09%,CAT|CYCS|GPX1|GPX3|GPX6|NCF4|PRDX2|PRDX6|SOD1|SOD2|TXN2,
Signaling by NOTCH,REACT:R-HSA-157118,2.93E-10,5.48E-07,17,112/43037 genes: 0.26%,ADAM17|ARRB2|ATP2A2|CCND1|CREB1|CUL1|E2F1|HDAC8|JAG1|JUN|MDK|MYC|NOTCH1|NOTCH2|TFDP2|TLE1|TP53,
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,REACT:R-HSA-174178,4.46E-10,8.37E-07,14,73/43037 genes: 0.17%,ANAPC7|AURKA|AURKB|CDC20|CDC23|CDC26|FZR1|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Metabolism of xenobiotics by cytochrome P450,KEGG:hsa00980,4.46E-10,8.37E-07,14,73/43037 genes: 0.17%,ADH5|CYP1A1|CYP1A2|CYP1B1|CYP2B6|CYP3A4|EPHX1|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MGST1|MGST2,
Transport to the Golgi and subsequent modification,REACT:R-HSA-948021,4.54E-10,8.51E-07,20,164/43037 genes: 0.38%,ANK1|ARFGAP2|CGA|COG1|COPB1|CSNK1D|DCTN2|GRIA1|INS|LHB|LMAN2|MAN2A1|PPP6R3|SEC22B|ST6GAL1|ST8SIA3|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9,
Signaling by RAS mutants,REACT:R-HSA-6802949,5.01E-10,9.39E-07,12,50/43037 genes: 0.12%,ARAF|ARRB2|FGB|IQGAP1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1|RAP1A|SRC,
Synthesis of DNA,REACT:R-HSA-69239,5.07E-10,9.51E-07,16,101/43037 genes: 0.23%,CDC6|CDK2|CDKN1A|DNA2|FZR1|LIG1|MCM2|ORC4|ORC5|PCNA|PSMA2|PSMA4|PSMC4|PSMD1|RB1|RFC4,
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors,REACT:R-HSA-8864260,5.39E-10,1.01E-06,11,40/43037 genes: 0.09%,APOE|CDKN1A|CGA|EGFR|ESR1|KIT|MYC|NOP2|NPM1|VEGFA|WWOX,
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,REACT:R-HSA-8862803,5.71E-10,1.07E-06,9,23/43037 genes: 0.05%,APP|BCL2L11|CDC25B|CDC25C|FOXO3|JUN|LMNB1|PRDX2|SOD2,
Neurodegenerative Diseases,REACT:R-HSA-8863678,5.71E-10,1.07E-06,9,23/43037 genes: 0.05%,APP|BCL2L11|CDC25B|CDC25C|FOXO3|JUN|LMNB1|PRDX2|SOD2,
Beta-catenin independent WNT signaling,REACT:R-HSA-3858494,5.72E-10,1.07E-06,19,149/43037 genes: 0.35%,ARRB2|CALM2|CAMK2A|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|PARD6A|PLCB1|PPP3R1|PSMA2|PSMA4|PSMC4|PSMD1|TCF7|WNT4|WNT5A,
Activation of BH3-only proteins,REACT:R-HSA-114452,5.73E-10,1.07E-06,10,31/43037 genes: 0.07%,AKT2|BBC3|BCL2|BCL2L11|BID|E2F1|PPP1R13B|PPP3R1|TFDP2|TP53,
MAPK targets/ Nuclear events mediated by MAP kinases,REACT:R-HSA-450282,5.73E-10,1.07E-06,10,31/43037 genes: 0.07%,ATF1|ATF2|CREB1|ELK1|FOS|JUN|MAPK1|MAPK10|MAPK3|PPP2R1A,
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors,REACT:R-HSA-629594,6.20E-10,1.16E-06,7,11/43037 genes: 0.03%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4,
AURKA Activation by TPX2,REACT:R-HSA-8854518,6.50E-10,1.22E-06,14,75/43037 genes: 0.17%,AURKA|CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|HMMR|PLK1|PLK4|PPP2R1A,
Apoptotic factor-mediated response,REACT:R-HSA-111471,6.54E-10,1.23E-06,6,7/43037 genes: 0.02%,APAF1|CASP3|CASP7|CASP9|CYCS|DIABLO,
Signaling by FGFR,REACT:R-HSA-190236,7.18E-10,1.35E-06,15,89/43037 genes: 0.21%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|GTF2F1|MAPK1|MAPK3|POLR2B|POLR2F|PPP2R1A|SRC|TIAL1,
SUMO E3 ligases SUMOylate target proteins,REACT:R-HSA-3108232,7.93E-10,1.49E-06,16,104/43037 genes: 0.24%,AURKA|AURKB|BIRC5|BRCA1|CDCA8|CETN2|HERC2|MDC1|MDM2|NUP133|NUP214|PARP1|PCNA|RAE1|SMC1A|TP53,
NOD1/2 Signaling Pathway,REACT:R-HSA-168638,8.17E-10,1.53E-06,10,32/43037 genes: 0.07%,BIRC2|BIRC3|CARD9|CASP4|CASP8|CASP9|MAP2K6|MAPK12|MAPK13|RIPK2,
p53-Dependent G1 DNA Damage Response,REACT:R-HSA-69563,1.08E-09,2.03E-06,13,65/43037 genes: 0.15%,ATM|CCNE1|CCNE2|CDK2|CDKN1A|CHEK2|MDM2|MDM4|PSMA2|PSMA4|PSMC4|PSMD1|TP53,
p53-Dependent G1/S DNA damage checkpoint,REACT:R-HSA-69580,1.08E-09,2.03E-06,13,65/43037 genes: 0.15%,ATM|CCNE1|CCNE2|CDK2|CDKN1A|CHEK2|MDM2|MDM4|PSMA2|PSMA4|PSMC4|PSMD1|TP53,
Negative regulation of FGFR1 signaling,REACT:R-HSA-5654726,1.15E-09,2.16E-06,10,33/43037 genes: 0.08%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|MAPK1|MAPK3|PPP2R1A|SRC,
Lysosome,KEGG:hsa04142,1.30E-09,2.44E-06,17,123/43037 genes: 0.29%,ACP5|AP1M2|AP3D1|ARSB|CTSB|CTSD|DNASE2|LAMP1|LGMN|LITAF|MAN2B1|NPC1|NPC2|PPT1|PPT2|SLC17A5|TCIRG1,
Platelet activation,KEGG:hsa04611,1.30E-09,2.44E-06,17,123/43037 genes: 0.29%,ACTB|AKT2|COL1A1|FGB|FYN|ITGA2B|MAPK1|MAPK12|MAPK13|MAPK3|MYLK|PIK3R2|PLCB1|RAP1A|SNAP23|SRC|VAMP8,
Regulation of TP53 Activity through Phosphorylation,REACT:R-HSA-6804756,1.36E-09,2.55E-06,15,93/43037 genes: 0.22%,ATM|AURKA|AURKB|BRCA1|CDK2|CHEK2|DNA2|HIPK1|MDM2|MDM4|PRKAB1|RAD1|RFC4|TOPBP1|TP53,
"Fatty acid, triacylglycerol, and ketone body metabolism",REACT:R-HSA-535734,1.45E-09,2.72E-06,24,252/43037 genes: 0.59%,ACADS|ACLY|ACOT11|ACSF2|ACSL4|ACSL5|ACSM3|AGT|AHR|APOA1|CYP1A1|ELOVL7|HSD17B12|LPIN2|MED17|MED28|MED30|MED6|NFYC|PPT1|PPT2|RXRA|SIN3A|TRIB3,
African trypanosomiasis,KEGG:hsa05143,1.60E-09,2.99E-06,10,34/43037 genes: 0.08%,APOA1|HBA1|HBA2|IL10|IL18|IL1B|IL6|MYD88|PLCB1|TNF,
G1/S DNA Damage Checkpoints,REACT:R-HSA-69615,1.61E-09,3.01E-06,13,67/43037 genes: 0.16%,ATM|CCNE1|CCNE2|CDK2|CDKN1A|CHEK2|MDM2|MDM4|PSMA2|PSMA4|PSMC4|PSMD1|TP53,
Amoebiasis,KEGG:hsa05146,1.84E-09,3.46E-06,15,95/43037 genes: 0.22%,ACTN1|C8B|CASP3|COL1A1|IL10|IL1B|IL6|LAMA5|LAMB1|NFKB1|PIK3R2|PLCB1|TGFB1|TGFB3|TNF,
Senescence-Associated Secretory Phenotype (SASP),REACT:R-HSA-2559582,1.85E-09,3.47E-06,16,110/43037 genes: 0.26%,ANAPC7|CDC23|CDC26|CDK2|CDK6|CDKN1A|CEBPB|FOS|FZR1|H2AFZ|IL6|JUN|MAPK1|MAPK3|NFKB1|UBE2C,
WNT ligand biogenesis and trafficking,REACT:R-HSA-3238698,2.06E-09,3.86E-06,9,26/43037 genes: 0.06%,WNT2|WNT2B|WNT3A|WNT4|WNT5A|WNT6|WNT7A|WNT9A|WNT9B,
Centrosome maturation,REACT:R-HSA-380287,2.22E-09,4.16E-06,14,82/43037 genes: 0.19%,CCNB1|CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A|TUBGCP2,
Recruitment of mitotic centrosome proteins and complexes,REACT:R-HSA-380270,2.22E-09,4.16E-06,14,82/43037 genes: 0.19%,CCNB1|CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A|TUBGCP2,
Adipocytokine signaling pathway,KEGG:hsa04920,2.35E-09,4.41E-06,13,69/43037 genes: 0.16%,ACSL4|ACSL5|AKT2|MAPK10|MTOR|NFKB1|NPY|POMC|PRKAB1|RXRA|TNF|TNFRSF1A|TRADD,
p75 NTR receptor-mediated signalling,REACT:R-HSA-193704,2.48E-09,4.66E-06,15,97/43037 genes: 0.23%,ADAM17|ARHGEF5|ARHGEF6|BCL2L11|BEX3|CASP3|ECT2|FGD1|MYD88|NET1|NFKB1|NGF|RIPK2|RTN4|SQSTM1,
VEGF binds to VEGFR leading to receptor dimerization,REACT:R-HSA-195399,2.57E-09,4.81E-06,6,8/43037 genes: 0.02%,FLT4|KDR|PGF|VEGFA|VEGFB|VEGFC,
VEGF ligand-receptor interactions,REACT:R-HSA-194313,2.57E-09,4.81E-06,6,8/43037 genes: 0.02%,FLT4|KDR|PGF|VEGFA|VEGFB|VEGFC,
Ras activation uopn Ca2+ infux through NMDA receptor,REACT:R-HSA-442982,2.64E-09,4.95E-06,8,19/43037 genes: 0.04%,CALM2|CAMK2A|CAMK2B|CAMK2G|GRIN1|GRIN2B|GRIN2C|NEFL,
Type II diabetes mellitus,KEGG:hsa04930,2.77E-09,5.19E-06,11,46/43037 genes: 0.11%,ABCC8|HK2|INS|MAPK1|MAPK10|MAPK3|MTOR|PIK3R2|PRKCD|SLC2A2|TNF,
B cell receptor signaling pathway,KEGG:hsa04662,2.83E-09,5.32E-06,13,70/43037 genes: 0.16%,AKT2|FOS|IFITM1|INPP5D|JUN|MAP2K1|MAP2K2|MAPK1|MAPK3|NFKB1|PIK3R2|PPP3R1|RAF1,
Regulation of HSF1-mediated heat shock response,REACT:R-HSA-3371453,2.83E-09,5.32E-06,13,70/43037 genes: 0.16%,ATM|BAG1|BAG2|BAG3|DNAJB1|HSPA14|HSPA1A|HSPA9|MAPK1|MAPK3|NUP133|NUP214|RAE1,
Cell cycle - G1/S transition,KEGG:hsa_M00692,3.11E-09,5.82E-06,7,13/43037 genes: 0.03%,CCND1|CCNE1|CCNE2|CDK2|CDK6|E2F1|RB1,
Hedgehog signaling pathway,KEGG:hsa04340,3.54E-09,6.65E-06,11,47/43037 genes: 0.11%,ARRB2|BCL2|BOC|CCND1|CSNK1D|CSNK1E|CUL1|GRK2|KIF7|PTCH2|SUFU,
GPCR downstream signaling,REACT:R-HSA-388396,3.86E-09,7.24E-06,53,1016/43037 genes: 2.36%,ADRA2B|ADRB1|ADRB2|AGT|AKT2|ANXA1|APP|ARHGEF5|ARHGEF6|ARRB2|AVPR1B|CCKBR|CGA|CHRM1|CHRM2|CHRM4|CHRM5|CORT|CRH|DGKI|DRD3|DRD4|ECT2|F2|FGD1|FSHB|GCG|GNRH1|GNRHR|GPR17|GRK2|GRM5|HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6|LHB|NET1|NPY|NTS|PENK|PIK3R2|PLCB1|POMC|PRKCD|PTH2|RGS18|RGS2|SSTR3|TAC1|VIPR2,
DNA Double-Strand Break Repair,REACT:R-HSA-5693532,3.99E-09,7.47E-06,19,167/43037 genes: 0.39%,APBB1|ATM|BABAM2|BRCA1|BRCA2|CDK2|CHEK2|DNA2|EYA2|HERC2|KDM4B|MDC1|NSD2|PARP1|PCNA|RAD1|RFC4|TOPBP1|TP53,
Adherens junction,KEGG:hsa04520,4.07E-09,7.63E-06,13,72/43037 genes: 0.17%,ACTB|ACTN1|EGFR|FGFR1|FYN|IQGAP1|MAPK1|MAPK3|MET|SRC|TCF7|TJP1|WASF2,
CLEC7A (Dectin-1) signaling,REACT:R-HSA-5607764,4.41E-09,8.27E-06,15,101/43037 genes: 0.23%,CALM2|CARD9|CASP8|CDC34|CUL1|IL1B|NFKB1|PPP3R1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|PYCARD|SRC,
Activation of caspases through apoptosome-mediated cleavage,REACT:R-HSA-111459,4.47E-09,8.37E-06,5,5/43037 genes: 0.01%,APAF1|CASP3|CASP7|CASP9|CYCS,
Cytochrome c-mediated apoptotic response,REACT:R-HSA-111461,4.47E-09,8.37E-06,5,5/43037 genes: 0.01%,APAF1|CASP3|CASP7|CASP9|CYCS,
Arachidonic acid metabolism,REACT:R-HSA-2142753,4.74E-09,8.89E-06,12,60/43037 genes: 0.14%,ABCC1|ALOX15|ALOX5|CYP1A1|CYP1A2|CYP1B1|CYP8B1|EPHX2|GPX1|GPX4|LTA4H|PON1,
Long-term depression,KEGG:hsa04730,4.74E-09,8.89E-06,12,60/43037 genes: 0.14%,ARAF|CRH|GRIA1|GRIA2|IGF1|MAP2K1|MAP2K2|MAPK1|MAPK3|PLCB1|PPP2R1A|RAF1,
Binding and Uptake of Ligands by Scavenger Receptors,REACT:R-HSA-2173782,5.70E-09,1.07E-05,11,49/43037 genes: 0.11%,ALB|AMBP|APOA1|APOB|APOE|CALR|COL1A1|HBA1|HBA2|HSP90B1|SCARB1,
Malaria,KEGG:hsa05144,5.70E-09,1.07E-05,11,49/43037 genes: 0.11%,HBA1|HBA2|IL10|IL18|IL1B|IL6|MET|MYD88|TGFB1|TGFB3|TNF,
Cytokine-cytokine receptor interaction,KEGG:hsa04060,5.71E-09,1.07E-05,24,270/43037 genes: 0.63%,CCL1|EGFR|FLT4|GH1|IL10|IL10RB|IL18|IL1B|IL6|KDR|KIT|MET|PDGFA|PDGFC|PDGFRA|PDGFRB|PRL|TGFB1|TGFB3|TNF|TNFRSF1A|VEGFA|VEGFB|VEGFC,
Glucagon signaling pathway,KEGG:hsa04922,5.82E-09,1.09E-05,15,103/43037 genes: 0.24%,AKT2|ATF2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|GCG|PLCB1|PPP3R1|PRKAB1|PRMT1|PYGM|SIK1|SLC2A2,
Ion channel transport,REACT:R-HSA-983712,5.88E-09,1.10E-05,21,209/43037 genes: 0.49%,ANO10|ATP2A2|BEST1|CALM2|CAMK2A|CAMK2B|CAMK2G|GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|HTR3A|HTR3B|MCOLN2|RAF1|SGK1|SLC17A3|TCIRG1|TRPC1,
Acetylcholine Binding And Downstream Events,REACT:R-HSA-181431,6.10E-09,1.14E-05,7,14/43037 genes: 0.03%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4,
Activation of Nicotinic Acetylcholine Receptors,REACT:R-HSA-629602,6.10E-09,1.14E-05,7,14/43037 genes: 0.03%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4,
Postsynaptic nicotinic acetylcholine receptors,REACT:R-HSA-622327,6.10E-09,1.14E-05,7,14/43037 genes: 0.03%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA7|CHRNB4,
Signaling by FGFR2,REACT:R-HSA-5654738,6.85E-09,1.28E-05,13,75/43037 genes: 0.17%,FGF1|FGF17|FGF2|FGF22|FGF9|GTF2F1|MAPK1|MAPK3|POLR2B|POLR2F|PPP2R1A|SRC|TIAL1,
Highly calcium permeable nicotinic acetylcholine receptors,REACT:R-HSA-629597,7.56E-09,1.42E-05,6,9/43037 genes: 0.02%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNB4,
"Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds",REACT:R-HSA-425366,7.62E-09,1.43E-05,15,105/43037 genes: 0.24%,FGF21|RHBG|SLC13A3|SLC16A1|SLC16A7|SLC16A8|SLC18A1|SLC18A2|SLC22A1|SLC2A2|SLC44A1|SLC44A4|SLC6A12|SLC6A2|SLC6A3,
Extracellular matrix organization,REACT:R-HSA-1474244,8.34E-09,1.56E-05,25,297/43037 genes: 0.69%,ACTN1|ADAM17|CAPN3|CASP3|COL18A1|COL1A1|COL5A3|COL8A1|CTSB|CTSD|DST|FGB|FGF2|HTRA1|ITGA2B|ITGB7|KDR|LAMA5|LAMB1|MMP9|PDGFA|PLG|PSEN1|TGFB1|TGFB3,
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,REACT:R-HSA-176814,9.56E-09,1.79E-05,13,77/43037 genes: 0.18%,ANAPC7|CCNB1|CDC20|CDC23|CDC26|CDK1|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Regulation of DNA replication,REACT:R-HSA-69304,9.56E-09,1.79E-05,13,77/43037 genes: 0.18%,CDC6|CDK2|CDKN1A|E2F1|FZR1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RB1,
Insulin resistance,KEGG:hsa04931,9.93E-09,1.86E-05,15,107/43037 genes: 0.25%,AKT2|CREB1|IL6|INS|MAPK10|MTOR|NFKB1|PIK3R2|PRKAB1|PRKCD|PYGM|SLC2A2|TNF|TNFRSF1A|TRIB3,
Antifolate resistance,KEGG:hsa01523,1.21E-08,2.26E-05,9,31/43037 genes: 0.07%,ABCC1|ABCC2|ABCC4|ABCG2|DHFR|IL1B|IL6|NFKB1|TNF,
Negative regulation of FGFR4 signaling,REACT:R-HSA-5654733,1.21E-08,2.26E-05,9,31/43037 genes: 0.07%,FGF1|FGF17|FGF2|FGF9|FGFR4|MAPK1|MAPK3|PPP2R1A|SRC,
Mitophagy - animal,KEGG:hsa04137,1.24E-08,2.32E-05,12,65/43037 genes: 0.15%,BCL2L1|BCL2L13|BNIP3|BNIP3L|E2F1|FIS1|FOXO3|JUN|MAPK10|SQSTM1|SRC|TP53,
Oxidative Stress Induced Senescence,REACT:R-HSA-2559580,1.38E-08,2.58E-05,16,126/43037 genes: 0.29%,CDK6|E2F1|EED|EZH2|FOS|H2AFZ|JUN|MAP2K6|MAP2K7|MAPK1|MAPK10|MAPK3|MDM2|MDM4|TFDP2|TP53,
Adrenergic signaling in cardiomyocytes,KEGG:hsa04261,1.49E-08,2.79E-05,17,144/43037 genes: 0.33%,ADRB1|ADRB2|AKT2|ATF2|ATP2A2|BCL2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|MAPK1|MAPK12|MAPK13|MAPK3|PLCB1|PPP2R1A,
cGMP-PKG signaling pathway,KEGG:hsa04022,1.63E-08,3.06E-05,18,163/43037 genes: 0.38%,ADRA2B|ADRB1|ADRB2|AKT2|ATF2|ATP2A2|CALM2|CREB1|INS|MAP2K1|MAP2K2|MAPK1|MAPK3|MYLK|PLCB1|PPP3R1|RAF1|RGS2,
Oncogene Induced Senescence,REACT:R-HSA-2559585,1.65E-08,3.09E-05,9,32/43037 genes: 0.07%,CDK6|E2F1|ERF|MAPK1|MAPK3|MDM2|MDM4|TFDP2|TP53,
C-type lectin receptors (CLRs),REACT:R-HSA-5621481,1.65E-08,3.10E-05,17,145/43037 genes: 0.34%,CALM2|CARD9|CASP8|CDC34|CUL1|FYN|IL1B|NFKB1|PPP3R1|PRKCD|PSMA2|PSMA4|PSMC4|PSMD1|PYCARD|RAF1|SRC,
Circadian entrainment,KEGG:hsa04713,1.83E-08,3.43E-05,14,96/43037 genes: 0.22%,CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|FOS|GRIA1|GRIA2|GRIN1|GRIN2B|GRIN2C|MAPK1|MAPK3|PLCB1,
PCP/CE pathway,REACT:R-HSA-4086400,1.83E-08,3.43E-05,14,96/43037 genes: 0.22%,ARRB2|FZD1|FZD2|FZD3|FZD6|FZD7|FZD8|PARD6A|PSMA2|PSMA4|PSMC4|PSMD1|WNT4|WNT5A,
Activation of the AP-1 family of transcription factors,REACT:R-HSA-450341,1.86E-08,3.48E-05,6,10/43037 genes: 0.02%,ATF2|FOS|JUN|MAPK1|MAPK10|MAPK3,
Cell cycle - G2/M transition,KEGG:hsa_M00693,1.86E-08,3.48E-05,6,10/43037 genes: 0.02%,CCNB1|CCNB2|CDC25C|CDK1|CDK2|WEE1,
TNF signaling,REACT:R-HSA-75893,1.96E-08,3.68E-05,10,43/43037 genes: 0.10%,ADAM17|BIRC2|BIRC3|CASP8|FADD|NSMAF|SMPD3|TNF|TNFRSF1A|TRADD,
Epithelial cell signaling in Helicobacter pylori infection,KEGG:hsa05120,2.11E-08,3.96E-05,12,68/43037 genes: 0.16%,ADAM17|CASP3|EGFR|JUN|MAPK10|MAPK12|MAPK13|MET|NFKB1|SRC|TCIRG1|TJP1,
Carbon metabolism,KEGG:hsa01200,2.39E-08,4.48E-05,15,114/43037 genes: 0.26%,ACADS|ACO1|ADH5|CAT|ENO1|G6PD|GAPDH|GPT|HK2|IDH3B|PC|PGD|RPIA|SDSL|TPI1,
Glutamatergic synapse,KEGG:hsa04724,2.39E-08,4.48E-05,15,114/43037 genes: 0.26%,GRIA1|GRIA2|GRIK3|GRIN1|GRIN2B|GRIN2C|GRIN3B|GRK2|GRM5|MAPK1|MAPK3|PLCB1|PPP3R1|SLC38A1|TRPC1,
Negative feedback regulation of MAPK pathway,REACT:R-HSA-5674499,2.63E-08,4.93E-05,5,6/43037 genes: 0.01%,MAP2K1|MAP2K2|MAPK1|MAPK3|RAF1,
Negative regulation of FGFR2 signaling,REACT:R-HSA-5654727,2.97E-08,5.56E-05,9,34/43037 genes: 0.08%,FGF1|FGF17|FGF2|FGF22|FGF9|MAPK1|MAPK3|PPP2R1A|SRC,
Measles,KEGG:hsa05162,3.00E-08,5.63E-05,16,133/43037 genes: 0.31%,AKT2|BBC3|CCND1|CCNE1|CCNE2|CD3G|CDK2|CDK6|FYN|HSPA1A|IL1B|IL6|MYD88|NFKB1|PIK3R2|TP53,
Tight junction,KEGG:hsa04530,3.15E-08,5.91E-05,18,170/43037 genes: 0.40%,ACTB|ACTN1|CCND1|CGN|CLDN2|CLDN7|JUN|MAP2K7|MAPK10|OCLN|PARD6A|PARD6B|PCNA|PPP2R1A|PRKAB1|RAP1A|SRC|TJP1,
Polo-like kinase mediated events,REACT:R-HSA-156711,3.27E-08,6.12E-05,7,17/43037 genes: 0.04%,CCNB1|CCNB2|CDC25C|CENPF|LIN9|PLK1|WEE1,
Constitutive Signaling by AKT1 E17K in Cancer,REACT:R-HSA-5674400,3.37E-08,6.32E-05,8,25/43037 genes: 0.06%,AKT2|CASP9|CDKN1A|CREB1|FOXO3|MDM2|MTOR|TSC2,
RHO GTPases Activate Formins,REACT:R-HSA-5663220,3.41E-08,6.39E-05,15,117/43037 genes: 0.27%,ACTB|AURKB|BIRC5|CDC20|CDCA8|CENPE|CENPF|CENPO|MRTFA|NDC80|NUF2|NUP133|PLK1|PPP2R1A|SRC,
Bile secretion,KEGG:hsa04976,3.50E-08,6.56E-05,12,71/43037 genes: 0.16%,ABCB1|ABCC2|ABCC4|ABCG2|AQP9|CYP3A4|EPHX1|LDLR|RXRA|SCARB1|SLC10A1|SLC22A1,
Loss of Nlp from mitotic centrosomes,REACT:R-HSA-380259,4.12E-08,7.72E-05,12,72/43037 genes: 0.17%,CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A,
Loss of proteins required for interphase microtubule organization from the centrosome,REACT:R-HSA-380284,4.12E-08,7.72E-05,12,72/43037 genes: 0.17%,CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A,
Orc1 removal from chromatin,REACT:R-HSA-68949,4.12E-08,7.72E-05,12,72/43037 genes: 0.17%,CDC6|CDK2|CDKN1A|FZR1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RB1,
Switching of origins to a post-replicative state,REACT:R-HSA-69052,4.12E-08,7.72E-05,12,72/43037 genes: 0.17%,CDC6|CDK2|CDKN1A|FZR1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RB1,
Ligand-gated ion channel transport,REACT:R-HSA-975298,4.78E-08,8.96E-05,8,26/43037 genes: 0.06%,GABRA1|GABRA2|GABRB2|GABRB3|GABRG2|GABRR1|HTR3A|HTR3B,
HIV Infection,REACT:R-HSA-162906,4.96E-08,9.30E-05,21,236/43037 genes: 0.55%,AP1M2|CCNH|CCNT1|CCNT2|CHMP4C|CUL5|FYN|GTF2F1|LIG1|NMT1|NPM1|NUP133|NUP214|POLR2B|POLR2F|PSMA2|PSMA4|PSMC4|PSMD1|RAE1|VPS37C,
Removal of licensing factors from origins,REACT:R-HSA-69300,5.65E-08,1.06E-04,12,74/43037 genes: 0.17%,CDC6|CDK2|CDKN1A|FZR1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1|RB1,
Metabolism of water-soluble vitamins and cofactors,REACT:R-HSA-196849,6.02E-08,1.13E-04,15,122/43037 genes: 0.28%,ABCC1|ACP5|COASY|CTRC|CYP8B1|DHFR|GSTO1|GSTO2|LMBRD1|MMADHC|NAMPT|PARP4|PC|SLC19A2|SLC5A6,
Biosynthesis of amino acids,KEGG:hsa01230,6.60E-08,1.24E-04,12,75/43037 genes: 0.17%,ACO1|ALDH7A1|BCAT1|ENO1|GAPDH|GPT|IDH3B|NAGS|PC|RPIA|SDSL|TPI1,
Fc gamma R-mediated phagocytosis,KEGG:hsa04666,6.62E-08,1.24E-04,13,90/43037 genes: 0.21%,AKT2|BIN1|CRK|INPP5D|MAP2K1|MAPK1|MAPK3|PIK3R2|PLPP3|PRKCD|RAF1|SCIN|WASF2,
Activation of ATR in response to replication stress,REACT:R-HSA-176187,6.64E-08,1.25E-04,9,37/43037 genes: 0.09%,CDC25C|CDC6|CDC7|CDK2|MCM2|ORC4|ORC5|RAD1|RFC4,
Transport of inorganic cations/anions and amino acids/oligopeptides,REACT:R-HSA-425393,7.49E-08,1.40E-04,14,107/43037 genes: 0.25%,CALM2|SLC12A3|SLC12A4|SLC17A5|SLC1A5|SLC26A11|SLC26A4|SLC34A2|SLC38A1|SLC4A1|SLC6A12|SLC7A11|SLC7A2|SLC7A8,
APC/C:Cdc20 mediated degradation of mitotic proteins,REACT:R-HSA-176409,7.68E-08,1.44E-04,12,76/43037 genes: 0.18%,ANAPC7|CCNB1|CDC20|CDC23|CDC26|CDK1|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Longevity regulating pathway - multiple species,KEGG:hsa04213,7.72E-08,1.45E-04,11,62/43037 genes: 0.14%,AKT2|CAT|FOXO3|HSPA1A|IGF1|INS|MTOR|PIK3R2|PRKAB1|SOD1|SOD2,
Presynaptic nicotinic acetylcholine receptors,REACT:R-HSA-622323,7.87E-08,1.48E-04,6,12/43037 genes: 0.03%,CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNB4,
Serotonin receptors,REACT:R-HSA-390666,7.87E-08,1.48E-04,6,12/43037 genes: 0.03%,HTR1A|HTR1D|HTR2B|HTR2C|HTR5A|HTR6,
Phosphorylation of the APC/C,REACT:R-HSA-176412,8.15E-08,1.53E-04,7,19/43037 genes: 0.04%,ANAPC7|CCNB1|CDC23|CDC26|CDK1|PLK1|UBE2C,
Th1 and Th2 cell differentiation,KEGG:hsa04658,8.65E-08,1.62E-04,13,92/43037 genes: 0.21%,CD3G|FOS|JAG1|JUN|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|NOTCH1|NOTCH2|PPP3R1,
Signaling by TGF-beta Receptor Complex,REACT:R-HSA-170834,8.93E-08,1.67E-04,12,77/43037 genes: 0.18%,CCNT1|CCNT2|CGN|E2F5|JUNB|MEN1|MYC|NEDD8|PARD6A|PARP1|TFDP2|TGFB1,
Death Receptor Signalling,REACT:R-HSA-73887,9.18E-08,1.72E-04,10,50/43037 genes: 0.12%,ADAM17|BIRC2|BIRC3|CASP8|FADD|NSMAF|SMPD3|TNF|TNFRSF1A|TRADD,
Signaling by FGFR1,REACT:R-HSA-5654736,9.18E-08,1.72E-04,10,50/43037 genes: 0.12%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|MAPK1|MAPK3|PPP2R1A|SRC,
Phase 1 - Functionalization of compounds,REACT:R-HSA-211945,9.49E-08,1.78E-04,14,109/43037 genes: 0.25%,AADAC|ADH5|AHR|CYP1A1|CYP1A2|CYP1B1|CYP26A1|CYP2B6|CYP3A4|CYP8B1|EPHX1|MARC1|POMC|RXRA,
Apoptotic cleavage of cellular proteins,REACT:R-HSA-111465,1.09E-07,2.04E-04,9,39/43037 genes: 0.09%,BIRC2|CASP3|CASP7|CASP8|LMNB1|MAPT|OCLN|PRKCD|TJP1,
Glutathione conjugation,REACT:R-HSA-156590,1.09E-07,2.04E-04,9,39/43037 genes: 0.09%,CHAC1|GCLC|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MGST1|MGST2,
NF-kappa B signaling pathway,KEGG:hsa04064,1.12E-07,2.10E-04,13,94/43037 genes: 0.22%,ATM|BCL2|BCL2L1|BIRC2|BIRC3|IL1B|MYD88|NFKB1|PARP1|PIDD1|TNF|TNFRSF1A|TRADD,
Negative regulation of FGFR3 signaling,REACT:R-HSA-5654732,1.24E-07,2.32E-04,8,29/43037 genes: 0.07%,FGF1|FGF17|FGF2|FGF9|MAPK1|MAPK3|PPP2R1A|SRC,
Shigellosis,KEGG:hsa05131,1.28E-07,2.40E-04,11,65/43037 genes: 0.15%,ACTB|CRK|MAPK1|MAPK10|MAPK12|MAPK13|MAPK3|NFKB1|RIPK2|SRC|WASF2,
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest,REACT:R-HSA-6804116,1.44E-07,2.69E-04,6,13/43037 genes: 0.03%,CCNE1|CCNE2|CDK2|CDKN1A|E2F1|TP53,
Signaling by FGFR4,REACT:R-HSA-5654743,1.73E-07,3.25E-04,9,41/43037 genes: 0.10%,FGF1|FGF17|FGF2|FGF9|FGFR4|MAPK1|MAPK3|PPP2R1A|SRC,
The citric acid (TCA) cycle and respiratory electron transport,REACT:R-HSA-1428517,1.74E-07,3.26E-04,17,170/43037 genes: 0.40%,ATP5F1A|ATP5F1B|ATP6|COX20|CYCS|IDH3B|ND2|NDUFA12|NDUFAF6|NNT|PDK1|PDK4|RXRA|SLC16A1|SLC16A8|UCP3|UQCRH,
Asymmetric localization of PCP proteins,REACT:R-HSA-4608870,1.77E-07,3.32E-04,11,67/43037 genes: 0.16%,FZD1|FZD2|FZD3|FZD7|FZD8|PARD6A|PSMA2|PSMA4|PSMC4|PSMD1|WNT5A,
Signal transduction by L1,REACT:R-HSA-445144,1.81E-07,3.40E-04,7,21/43037 genes: 0.05%,EGFR|FGFR1|ITGA2B|MAP2K1|MAP2K2|MAPK1|MAPK3,
Aldosterone synthesis and secretion,KEGG:hsa04925,1.82E-07,3.42E-04,12,82/43037 genes: 0.19%,ATF1|ATF2|CALM2|CAMK2A|CAMK2B|CAMK2G|CREB1|HSD3B1|LDLR|PLCB1|SCARB1|STAR,
ER to Golgi Anterograde Transport,REACT:R-HSA-199977,1.91E-07,3.58E-04,15,133/43037 genes: 0.31%,ANK1|ARFGAP2|COG1|COPB1|CSNK1D|DCTN2|GRIA1|INS|LMAN2|PPP6R3|SEC22B|TRAPPC2|TRAPPC2L|TRAPPC6B|TRAPPC9,
Cargo recognition for clathrin-mediated endocytosis,REACT:R-HSA-8856825,2.09E-07,3.91E-04,13,99/43037 genes: 0.23%,ADRB2|APOB|ARRB2|CD3G|CHRM2|COPS6|EGFR|GRK2|LDLR|NEDD8|SLC18A3|VAMP8|WNT5A,
Apoptotic machinery,KEGG:hsa_M00685,2.09E-07,3.92E-04,4,4/43037 genes: 0.01%,APAF1|CASP3|CASP7|CASP9,
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes,REACT:R-HSA-69200,2.09E-07,3.92E-04,4,4/43037 genes: 0.01%,CCNE1|CCNE2|CDK2|RB1,
Cell-Cell communication,REACT:R-HSA-1500931,2.11E-07,3.95E-04,15,134/43037 genes: 0.31%,ACTN1|ARHGEF6|CDH2|CLDN2|CLDN7|DST|FYN|IQGAP1|MAPK12|MAPK13|NTN1|PARD6A|PARD6B|PIK3R2|SRC,
tRNA modification in the nucleus and cytosol,REACT:R-HSA-6782315,2.16E-07,4.06E-04,9,42/43037 genes: 0.10%,ADAT3|ALKBH8|CTU2|PUS1|QTRT1|TPRKB|TRMT6|TRMT61A|TYW3,
TGF-beta signaling pathway,KEGG:hsa04350,2.39E-07,4.49E-04,12,84/43037 genes: 0.20%,ACVR1C|CUL1|E2F5|FST|ID2|MAPK1|MAPK3|MYC|PPP2R1A|TGFB1|TGFB3|TNF,
Drug metabolism - cytochrome P450,KEGG:hsa00982,2.42E-07,4.53E-04,11,69/43037 genes: 0.16%,ADH5|CYP1A2|CYP2B6|CYP3A4|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MGST1|MGST2,
Golgi Cisternae Pericentriolar Stack Reorganization,REACT:R-HSA-162658,2.47E-07,4.62E-04,6,14/43037 genes: 0.03%,CCNB1|CCNB2|CDK1|MAPK1|MAPK3|PLK1,
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain,REACT:R-HSA-6803205,2.47E-07,4.62E-04,6,14/43037 genes: 0.03%,BCL2L14|BCL6|BIRC5|PPP1R13B|RABGGTB|TP53,
TP53 Regulates Metabolic Genes,REACT:R-HSA-5628897,2.73E-07,5.12E-04,12,85/43037 genes: 0.20%,AKT2|COX20|CYCS|DDIT4|G6PD|MTOR|PRDX2|PRKAB1|SESN1|TP53|TSC1|TSC2,
APC/C:Cdc20 mediated degradation of Cyclin B,REACT:R-HSA-174048,3.68E-07,6.90E-04,7,23/43037 genes: 0.05%,ANAPC7|CCNB1|CDC20|CDC23|CDC26|CDK1|UBE2C,
RAF-independent MAPK1/3 activation,REACT:R-HSA-112409,3.68E-07,6.90E-04,7,23/43037 genes: 0.05%,CDK1|DUSP1|IL6|MAP2K1|MAP2K2|MAPK1|MAPK3,
FGFR2 mutant receptor activation,REACT:R-HSA-1839126,3.72E-07,6.97E-04,8,33/43037 genes: 0.08%,FGF1|FGF17|FGF2|FGF22|FGF9|GTF2F1|POLR2B|POLR2F,
Parkinson's disease,KEGG:hsa05012,4.50E-07,8.44E-04,15,142/43037 genes: 0.33%,APAF1|ATP5F1A|ATP5F1B|ATP6|CASP3|CASP9|CYCS|ND2|NDUFA12|SLC18A1|SLC18A2|SLC6A3|SNCA|TH|UQCRH,
Interleukin-1 signaling,REACT:R-HSA-446652,4.95E-07,9.28E-04,9,46/43037 genes: 0.11%,CUL1|IL1B|IRAK3|MAP2K1|MAP2K6|MYD88|NFKB1|RIPK2|SQSTM1,
Lipoprotein metabolism,REACT:R-HSA-174824,5.03E-07,9.43E-04,11,74/43037 genes: 0.17%,ALB|APOA1|APOB|APOE|CIDEC|FGF21|FYN|LDLR|NPC1|NPC2|SCARB1,
Thyroid hormone synthesis,KEGG:hsa04918,5.03E-07,9.43E-04,11,74/43037 genes: 0.17%,ALB|ATF2|CGA|CREB1|GPX1|GPX3|GPX6|HSP90B1|PDIA4|PLCB1|SLC26A4,
Vitamin digestion and absorption,KEGG:hsa04977,5.10E-07,9.56E-04,7,24/43037 genes: 0.06%,ABCC1|APOA1|APOB|LMBRD1|SCARB1|SLC19A2|SLC5A6,
ABC-family proteins mediated transport,REACT:R-HSA-382556,5.22E-07,9.79E-04,13,107/43037 genes: 0.25%,ABCB1|ABCC1|ABCC2|ABCC4|ABCC8|ABCE1|APOA1|DERL2|PSMA2|PSMA4|PSMC4|PSMD1|VCP,
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members,REACT:R-HSA-111453,5.24E-07,9.82E-04,5,9/43037 genes: 0.02%,BBC3|BCL2|BCL2L1|BCL2L11|BID,
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks,REACT:R-HSA-5693565,5.78E-07,0.00108,11,75/43037 genes: 0.17%,APBB1|ATM|BABAM2|BRCA1|CHEK2|EYA2|HERC2|KDM4B|MDC1|NSD2|TP53,
BRCA1-associated genome surveillance complex (BASC),KEGG:hsa_M00295,6.34E-07,0.00119,6,16/43037 genes: 0.04%,ATM|BRCA1|MSH2|MSH6|PCNA|RFC4,
FGFR1 ligand binding and activation,REACT:R-HSA-190242,6.34E-07,0.00119,6,16/43037 genes: 0.04%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1,
Phospholipase C-mediated cascade: FGFR1,REACT:R-HSA-5654219,6.34E-07,0.00119,6,16/43037 genes: 0.04%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1,
tRNA processing,REACT:R-HSA-72306,6.48E-07,0.00122,13,109/43037 genes: 0.25%,ADAT3|ALKBH8|CTU2|NUP133|NUP214|PUS1|QTRT1|RAE1|TPRKB|TRMT6|TRMT61A|TRMU|TYW3,
SCF(Skp2)-mediated degradation of p27/p21,REACT:R-HSA-187577,6.51E-07,0.00122,10,61/43037 genes: 0.14%,CCND1|CCNE1|CCNE2|CDK2|CDKN1A|CUL1|PSMA2|PSMA4|PSMC4|PSMD1,
The role of GTSE1 in G2/M progression after G2 checkpoint,REACT:R-HSA-8852276,6.51E-07,0.00122,10,61/43037 genes: 0.14%,CCNB1|CCNB2|CDK1|CDKN1A|PLK1|PSMA2|PSMA4|PSMC4|PSMD1|TP53,
DNA Double Strand Break Response,REACT:R-HSA-5693606,6.63E-07,0.00124,11,76/43037 genes: 0.18%,APBB1|ATM|BABAM2|BRCA1|CHEK2|EYA2|HERC2|KDM4B|MDC1|NSD2|TP53,
Nucleotide Excision Repair,REACT:R-HSA-5696398,8.88E-07,0.00167,13,112/43037 genes: 0.26%,ACTB|ACTR5|CCNH|CETN2|COPS6|LIG1|MCRS1|PARP1|PCNA|POLR2B|POLR2F|RAD23B|RFC4,
Signaling by FGFR in disease,REACT:R-HSA-1226099,8.88E-07,0.00167,10,63/43037 genes: 0.15%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1|FGFR4|GTF2F1|POLR2B|POLR2F,
Inflammasomes,REACT:R-HSA-622312,9.62E-07,0.0018,6,17/43037 genes: 0.04%,APP|BCL2|BCL2L1|P2RX7|PYCARD|SUGT1,
"Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline",KEGG:hsa_M00042,1.03E-06,0.00193,4,5/43037 genes: 0.01%,DBH|PNMT|TH|TYR,
Cyclin B2 mediated events,REACT:R-HSA-157881,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CCNB2|CDC25B|CDC25C|CDK1,
G2/M DNA replication checkpoint,REACT:R-HSA-69478,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CCNB1|CCNB2|CDK1|WEE1,
Muscarinic acetylcholine receptors,REACT:R-HSA-390648,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CHRM1|CHRM2|CHRM4|CHRM5,
SMAC binds to IAPs,REACT:R-HSA-111463,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CASP3|CASP7|CASP9|DIABLO,
SMAC-mediated apoptotic response,REACT:R-HSA-111469,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CASP3|CASP7|CASP9|DIABLO,
SMAC-mediated dissociation of IAP:caspase complexes,REACT:R-HSA-111464,1.03E-06,0.00193,4,5/43037 genes: 0.01%,CASP3|CASP7|CASP9|DIABLO,
Activation of PUMA and translocation to mitochondria,REACT:R-HSA-139915,1.03E-06,0.00193,5,10/43037 genes: 0.02%,BBC3|E2F1|PPP1R13B|TFDP2|TP53,
Leukocyte transendothelial migration,KEGG:hsa04670,1.09E-06,0.00204,13,114/43037 genes: 0.26%,ACTB|ACTN1|CLDN2|CLDN7|MAPK12|MAPK13|MMP9|NCF4|NOX1|OCLN|PIK3R2|RAP1A|SIPA1,
Metabolism of nucleotides,REACT:R-HSA-15869,1.17E-06,0.0022,12,97/43037 genes: 0.23%,ADSL|AGXT2|CAT|DCK|DTYMK|ENTPD7|GMPS|GPX1|PNP|RRM2|TK1|XDH,
Amine-derived hormones,REACT:R-HSA-209776,1.42E-06,0.00266,6,18/43037 genes: 0.04%,CGA|DBH|PNMT|TH|TPH1|TPH2,
Nuclear Envelope Breakdown,REACT:R-HSA-2980766,1.47E-06,0.00276,9,52/43037 genes: 0.12%,CCNB1|CCNB2|CDK1|LMNB1|LPIN2|NUP133|NUP214|PLK1|RAE1,
Jak-STAT signaling pathway,KEGG:hsa04630,1.50E-06,0.00282,15,156/43037 genes: 0.36%,AKT2|BCL2|BCL2L1|CCND1|CDKN1A|GFAP|GH1|IL10|IL10RB|IL6|MTOR|MYC|PIK3R2|PRL|RAF1,
Clathrin-mediated endocytosis,REACT:R-HSA-8856828,1.61E-06,0.00303,14,137/43037 genes: 0.32%,ADRB2|APOB|ARRB2|BIN1|CD3G|CHRM2|COPS6|EGFR|GRK2|LDLR|NEDD8|SLC18A3|VAMP8|WNT5A,
Dorso-ventral axis formation,KEGG:hsa04320,1.62E-06,0.00303,7,28/43037 genes: 0.07%,EGFR|MAP2K1|MAPK1|MAPK3|NOTCH1|NOTCH2|PIWIL2,
Anchoring of the basal body to the plasma membrane,REACT:R-HSA-5620912,1.63E-06,0.00305,12,100/43037 genes: 0.23%,CDK1|CEP164|CEP70|CETN2|CSNK1D|CSNK1E|DCTN2|HAUS1|HAUS8|PLK1|PLK4|PPP2R1A,
Influenza Infection,REACT:R-HSA-168254,1.63E-06,0.00305,15,157/43037 genes: 0.36%,CALR|DNAJC3|GRSF1|GTF2F1|HSPA1A|ISG15|NUP133|NUP214|POLR2B|POLR2F|RAE1|RPL6|RPS7|RPS8|TGFB1,
Peroxisome,KEGG:hsa04146,1.63E-06,0.00306,11,83/43037 genes: 0.19%,ACOX3|ACSL4|ACSL5|CAT|EPHX2|MPV17|PECR|PEX13|SOD1|SOD2|XDH,
Apoptotic execution  phase,REACT:R-HSA-75153,1.74E-06,0.00327,9,53/43037 genes: 0.12%,BIRC2|CASP3|CASP7|CASP8|LMNB1|MAPT|OCLN|PRKCD|TJP1,
Homology Directed Repair,REACT:R-HSA-5693538,1.76E-06,0.0033,14,138/43037 genes: 0.32%,ATM|BABAM2|BRCA1|BRCA2|CDK2|DNA2|HERC2|MDC1|NSD2|PARP1|PCNA|RAD1|RFC4|TOPBP1,
Signaling by Hedgehog,REACT:R-HSA-5358351,1.76E-06,0.0033,14,138/43037 genes: 0.32%,ADAM17|ARRB2|BOC|CUL1|DERL2|GRK2|KIF7|PSMA2|PSMA4|PSMC4|PSMD1|SUFU|SYVN1|VCP,
Negative regulation of MAPK pathway,REACT:R-HSA-5675221,1.80E-06,0.00338,8,40/43037 genes: 0.09%,ARAF|DUSP1|MAP2K1|MAP2K2|MAPK1|MAPK3|PPP2R1A|RAF1,
Signaling by FGFR3,REACT:R-HSA-5654741,1.80E-06,0.00338,8,40/43037 genes: 0.09%,FGF1|FGF17|FGF2|FGF9|MAPK1|MAPK3|PPP2R1A|SRC,
Tryptophan metabolism,KEGG:hsa00380,1.80E-06,0.00338,8,40/43037 genes: 0.09%,ALDH7A1|CAT|CYP1A1|CYP1A2|CYP1B1|KYAT1|TPH1|TPH2,
L1CAM interactions,REACT:R-HSA-373760,1.81E-06,0.0034,12,101/43037 genes: 0.23%,ANK1|EGFR|FGFR1|GAP43|ITGA2B|LAMB1|MAP2K1|MAP2K2|MAPK1|MAPK3|SCN2A|SRC,
Ub-specific processing proteases,REACT:R-HSA-5689880,1.82E-06,0.00341,18,223/43037 genes: 0.52%,ADRB2|AR|ARRB2|AXIN2|BIRC2|BIRC3|CDC20|KEAP1|MDM2|MDM4|MYC|PSMA2|PSMA4|PSMC4|PSMD1|TOMM20|TP53|USP16,
APC/C:Cdc20 mediated degradation of Securin,REACT:R-HSA-174154,1.83E-06,0.00344,10,68/43037 genes: 0.16%,ANAPC7|CDC20|CDC23|CDC26|PSMA2|PSMA4|PSMC4|PSMD1|PTTG1|UBE2C,
Cytochrome P450 - arranged by substrate type,REACT:R-HSA-211897,1.83E-06,0.00344,10,68/43037 genes: 0.16%,AHR|CYP1A1|CYP1A2|CYP1B1|CYP26A1|CYP2B6|CYP3A4|CYP8B1|POMC|RXRA,
Androgen biosynthesis,REACT:R-HSA-193048,1.85E-06,0.00347,5,11/43037 genes: 0.03%,CGA|HSD17B12|HSD3B1|LHB|POMC,
Signaling by activated point mutants of FGFR1,REACT:R-HSA-1839122,1.85E-06,0.00347,5,11/43037 genes: 0.03%,FGF1|FGF17|FGF2|FGF9|FGFR1,
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,REACT:R-HSA-176407,2.03E-06,0.00381,6,19/43037 genes: 0.04%,ANAPC7|CDC20|CDC23|CDC26|FZR1|UBE2C,
Na+/Cl- dependent neurotransmitter transporters,REACT:R-HSA-442660,2.03E-06,0.00381,6,19/43037 genes: 0.04%,SLC18A1|SLC18A2|SLC22A1|SLC6A12|SLC6A2|SLC6A3,
Fatty Acyl-CoA Biosynthesis,REACT:R-HSA-75105,2.05E-06,0.00384,9,54/43037 genes: 0.13%,ACLY|ACOT11|ACSF2|ACSL4|ACSL5|ELOVL7|HSD17B12|PPT1|PPT2,
Mitochondrial biogenesis,REACT:R-HSA-1592230,2.05E-06,0.00384,9,54/43037 genes: 0.13%,ATF2|ATP5F1B|CREB1|CYCS|MAPK12|PPRC1|PRKAB1|RXRA|TFB1M,
Global Genome Nucleotide Excision Repair (GG-NER),REACT:R-HSA-5696399,2.07E-06,0.00389,11,85/43037 genes: 0.20%,ACTB|ACTR5|CCNH|CETN2|COPS6|LIG1|MCRS1|PARP1|PCNA|RAD23B|RFC4,
Insulin secretion,KEGG:hsa04911,2.07E-06,0.00389,11,85/43037 genes: 0.20%,ABCC8|ATF2|CAMK2A|CAMK2B|CAMK2G|CREB1|GCG|INS|PLCB1|SLC2A2|SNAP25,
Chemokine signaling pathway,KEGG:hsa04062,2.23E-06,0.00418,16,182/43037 genes: 0.42%,AKT2|ARRB2|CCL1|CRK|FOXO3|GRK2|MAP2K1|MAPK1|MAPK3|NFKB1|PIK3R2|PLCB1|PRKCD|RAF1|RAP1A|SRC,
Mitotic Prophase,REACT:R-HSA-68875,2.28E-06,0.00427,14,141/43037 genes: 0.33%,CCNB1|CCNB2|CDK1|H2AFZ|LMNB1|LPIN2|MAPK1|MAPK3|NUP133|NUP214|PLK1|PPP2R1A|RAE1|RB1,
DNA Replication Pre-Initiation,REACT:R-HSA-69002,2.33E-06,0.00437,11,86/43037 genes: 0.20%,CDC6|CDC7|CDK2|E2F1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1,
M/G1 Transition,REACT:R-HSA-68874,2.33E-06,0.00437,11,86/43037 genes: 0.20%,CDC6|CDC7|CDK2|E2F1|MCM2|ORC4|ORC5|PSMA2|PSMA4|PSMC4|PSMD1,
Pre-NOTCH Transcription and Translation,REACT:R-HSA-1912408,2.68E-06,0.00503,7,30/43037 genes: 0.07%,CCND1|E2F1|JUN|NOTCH1|NOTCH2|TFDP2|TP53,
Stabilization of p53,REACT:R-HSA-69541,2.81E-06,0.00527,9,56/43037 genes: 0.13%,ATM|CHEK2|MDM2|MDM4|PSMA2|PSMA4|PSMC4|PSMD1|TP53,
CLEC7A/inflammasome pathway,REACT:R-HSA-5660668,3.03E-06,0.00569,4,6/43037 genes: 0.01%,CASP8|IL1B|NFKB1|PYCARD,
FGFR1b ligand binding and activation,REACT:R-HSA-190370,3.03E-06,0.00569,4,6/43037 genes: 0.01%,FGF1|FGF2|FGF22|FGFR1,
TNFR1-mediated ceramide production,REACT:R-HSA-5626978,3.03E-06,0.00569,4,6/43037 genes: 0.01%,NSMAF|SMPD3|TNF|TNFRSF1A,
Chromatin modifying enzymes,REACT:R-HSA-3247509,3.11E-06,0.00584,20,279/43037 genes: 0.65%,ACTB|ASH2L|ATF2|CCND1|EED|ELP2|ELP3|EZH2|H2AFZ|HDAC8|JMJD6|KDM4B|MCRS1|MTA3|NFKB1|NSD2|PRMT1|PRMT3|PRMT6|SMARCA4,
Chromatin organization,REACT:R-HSA-4839726,3.11E-06,0.00584,20,279/43037 genes: 0.65%,ACTB|ASH2L|ATF2|CCND1|EED|ELP2|ELP3|EZH2|H2AFZ|HDAC8|JMJD6|KDM4B|MCRS1|MTA3|NFKB1|NSD2|PRMT1|PRMT3|PRMT6|SMARCA4,
FGFR1c ligand binding and activation,REACT:R-HSA-190373,3.12E-06,0.00585,5,12/43037 genes: 0.03%,FGF1|FGF17|FGF2|FGF9|FGFR1,
Signaling by FGFR2 in disease,REACT:R-HSA-5655253,3.21E-06,0.00602,8,43/43037 genes: 0.10%,FGF1|FGF17|FGF2|FGF22|FGF9|GTF2F1|POLR2B|POLR2F,
Rheumatoid arthritis,KEGG:hsa05323,3.28E-06,0.00615,11,89/43037 genes: 0.21%,ACP5|FOS|IL18|IL1B|IL6|JUN|TCIRG1|TGFB1|TGFB3|TNF|VEGFA,
Phase II conjugation,REACT:R-HSA-156580,3.35E-06,0.00628,12,107/43037 genes: 0.25%,CHAC1|COMT|CYP1A2|GCLC|GSTA5|GSTM3|GSTM4|GSTO1|GSTO2|MGST1|MGST2|UGP2,
Cdc20:Phospho-APC/C mediated degradation of Cyclin A,REACT:R-HSA-174184,3.56E-06,0.00668,10,73/43037 genes: 0.17%,ANAPC7|CDC20|CDC23|CDC26|CDK1|PSMA2|PSMA4|PSMC4|PSMD1|UBE2C,
Viral myocarditis,KEGG:hsa05416,3.80E-06,0.00713,9,58/43037 genes: 0.13%,ACTB|BID|CASP3|CASP8|CASP9|CCND1|CYCS|EIF4G1|FYN,
PI-3K cascade:FGFR1,REACT:R-HSA-5654689,3.92E-06,0.00735,6,21/43037 genes: 0.05%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1,
Scavenging by Class A Receptors,REACT:R-HSA-3000480,3.92E-06,0.00735,6,21/43037 genes: 0.05%,APOA1|APOB|APOE|CALR|COL1A1|HSP90B1,
SHC-mediated cascade:FGFR1,REACT:R-HSA-5654688,3.92E-06,0.00735,6,21/43037 genes: 0.05%,FGF1|FGF17|FGF2|FGF22|FGF9|FGFR1,
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint,REACT:R-HSA-179419,4.04E-06,0.00757,10,74/43037 genes: 0.17%,ANAPC7|CDC20|CDC23|CDC26|CDK1|PSMA2|PSMA4|PSMC4|PSMD1|UBE2C,
Peptide hormone metabolism,REACT:R-HSA-2980736,4.09E-06,0.00767,11,91/43037 genes: 0.21%,AGT|CGA|CPB1|CTSD|FSHB|GCG|GH1|IGF1|INS|LHB|POMC,
AKT phosphorylates targets in the cytosol,REACT:R-HSA-198323,4.98E-06,0.00934,5,13/43037 genes: 0.03%,AKT2|CASP9|CDKN1A|MDM2|TSC2,
GABA A receptor activation,REACT:R-HSA-977441,4.98E-06,0.00934,5,13/43037 genes: 0.03%,GABRA1|GABRA2|GABRB2|GABRB3|GABRG2,
Hormone ligand-binding receptors,REACT:R-HSA-375281,4.98E-06,0.00934,5,13/43037 genes: 0.03%,CGA|FSHB|GNRH1|GNRHR|LHB,
TNFR1-induced proapoptotic signaling,REACT:R-HSA-5357786,4.98E-06,0.00934,5,13/43037 genes: 0.03%,CASP8|FADD|TNF|TNFRSF1A|TRADD,
Uptake and function of anthrax toxins,REACT:R-HSA-5210891,4.98E-06,0.00934,5,13/43037 genes: 0.03%,CALM2|MAP2K1|MAP2K2|MAP2K6|MAP2K7,
"Cell death signalling via NRAGE, NRIF and NADE",REACT:R-HSA-204998,5.16E-06,0.00968,10,76/43037 genes: 0.18%,ARHGEF5|ARHGEF6|BCL2L11|BEX3|CASP3|ECT2|FGD1|NET1|NGF|SQSTM1,
Base excision repair,KEGG:hsa03410,5.32E-06,0.00997,7,33/43037 genes: 0.08%,APEX2|LIG1|MPG|NEIL1|PARP1|PARP4|PCNA,