Table 3. Identities of genes in cell proliferation cluster
Accession no. |
Gene symbol |
Gene name |
|
Up-regulated genes |
|||
R51580 |
NDN |
Necdin homolog (mouse) |
|
AA676797 |
CCNF |
Cyclin F |
|
W95001 |
CDC25C |
Cell division cycle 25C |
|
AI921113 |
HDAC5 |
Histone deacetylase 5 |
|
W80455 |
SLC12A6 |
Solute carrier family 12 (potassium/chloride transporters), member 6 |
|
AA400476 |
KIF2C |
Kinesin family member 2C |
|
AA284072 |
CDKN3 |
Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) |
|
R16712 |
ANLN |
Anillin, actin binding protein (scraps homolog, Drosophila) |
|
R06254 |
TPD52L2 |
Tumor protein D52-like 2 |
|
AA705886 |
MXI1 |
MAX interactor 1 |
|
H59204 |
CDC6 |
CDC6 cell division cycle 6 homolog (Saccharomyces cerevisiae) |
|
H82442 |
ID2 |
Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
|
AA279658 |
TREX1 |
Three prime repair exonuclease 1 |
|
AA397813 |
CKS2 |
CDC28 protein kinase regulatory subunit 2 |
|
AA082943 |
CCNG1 |
Cyclin G1 |
|
H79779 |
HDAC3 |
Histone deacetylase 3 |
|
AI017242 |
DCTN3 |
Dynactin 3 (p22) |
|
N72193 |
CETN2 |
Centrin, EF-hand protein, 2 |
|
T71991 |
CREG |
Cellular repressor of E1A-stimulated genes |
|
W93379 |
NEK2 |
NIMA (never in mitosis gene a)-related kinase 2 |
|
R43576 |
BLZF1 |
Basic leucine zipper nuclear factor 1 (JEM-1) |
|
H59620 |
INSIG1 |
Insulin induced gene 1 |
|
AA496930 |
RECK |
Reversion-inducing-cysteine-rich protein with kazal motifs |
|
AA464152 |
QSCN6 |
Quiescin Q6 |
|
AA157018 |
STIM1 |
Stromal interaction molecule 1 |
|
AA279804 |
RAP1A |
RAP1A, member of RAS oncogene family |
|
AA488168 |
DCTN1 |
Dynactin 1 (p150, glued homolog, Drosophila) |
|
AA704693 |
SIRT2 |
Sirtuin (silent mating-type information regulation 2 homolog) 2 (S. cerevisiae) |
|
AA447661 |
SESN1 |
Sestrin 1 |
|
AA775803 |
PRDX1 |
Peroxiredoxin 1 |
|
AA458870 |
CDC37 |
CDC37 cell division cycle 37 homolog (S. cerevisiae) |
|
AA608576 |
MAPRE2 |
Microtubule-associated protein, RP/EB family, member 2 |
|
AI279078 |
GPR21 |
G protein-coupled receptor 21 |
|
AA676460 |
KPNA2 |
Karyopherin a 2 (RAG cohort 1, importin a 1) |
|
AA489647 |
CCNG2 |
Cyclin G2 |
|
N26643 |
CDK2 |
Cyclin-dependent kinase 2 |
|
AA443347 |
SEPT8 |
Septin 8 |
|
AA903504 |
BLM |
Bloom syndrome |
|
AA129931 |
PPP1CC |
Protein phosphatase 1, catalytic subunit, g isoform |
|
AA775381 |
ORC4L |
Origin recognition complex, subunit 4-like (yeast) |
|
AA676705 |
CGRRF1 |
Cell growth regulator with ring finger domain 1 |
|
N70463 |
BTG1 |
B cell translocation gene 1, antiproliferative |
|
AA489679 |
GRLF1 |
Glucocorticoid receptor DNA binding factor 1 |
|
H93424 |
APRIN |
Androgen-induced proliferation inhibitor |
|
R79935 |
TIEG |
TGFB inducible early growth response |
|
AA045731 |
TIEG |
TGFB inducible early growth response |
|
NM_170607 |
TCFL4 |
Transcription factor-like 4 |
|
R83380 |
STAMBP |
STAM binding protein |
|
AA778663 |
TNFSF9 |
Tumor necrosis factor (ligand) superfamily, member 9 |
|
AA482119 |
ID3 |
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
|
AA490213 |
TOB1 |
Transducer of ERBB2, 1 |
|
W93891 |
MTVR1 |
Mouse Mammary Turmor Virus Receptor homolog 1 |
|
H86558 |
MAD |
MAX dimerization protein 1 |
|
H20743 |
CDC34 |
Cell division cycle 34 |
|
AA496147 |
TUSC2 |
Tumor suppressor candidate 2 |
|
M74093 |
CCNE1 |
Cyclin E1 |
|
N33574 |
ING1 |
Inhibitor of growth family, member 1 |
|
AA149095 |
DUSP1 |
Dual specificity phosphatase 1 |
|
H69583 |
BTG2 |
BTG family, member 2 |
|
AA866113 |
APBB2 |
Amyloid b (A4) precursor protein-binding, family B, member 2 (Fe65-like) |
|
Down-regulated genes |
|
||
AA774665 |
CCNB2 |
Cyclin B2 |
|
R19158 |
STK6 |
Serine/threonine kinase 6 |
|
H63492 |
STK6 |
Serine/threonine kinase 6 |
|
AA629262 |
PLK1 |
Polo-like kinase 1 (Drosophila) |
|
AA046523 |
CETN3 |
Centrin, EF-hand protein, 3 (CDC31 homolog, yeast) |
|
T54144 |
RIOK3 |
RIO kinase 3 (yeast) |
|
N62245 |
CDC7 |
CDC7 cell division cycle 7 (S. cerevisiae) |
|
AA215502 |
TUBE1 |
Tubulin, e 1 |
|
AI024518 |
SUV39H1 |
Suppressor of variegation 3-9 homolog 1 (Drosophila) |
|
AA157787 |
KNTC1 |
Kinetochore associated 1 |
|
AA683102 |
RAD21 |
RAD21 homolog (Schizosaccharomyces pombe) |
|
AA732873 |
PLK4 |
Polo-like kinase 4 (Drosophila) |
|
AA678139 |
NUBP1 |
Nucleotide binding protein 1 (mind homolog, Escherichia coli) |
|
AA609740 |
KATNA1 |
Katanin p60 (atpase-containing) subunit A 1 |
|
AA430504 |
UBE2C |
Ubiquitin-conjugating enzyme E2C |
|
AF208227 |
NCOA6 |
Nuclear receptor coactivator 6 |
|
AA496924 |
NF1 |
Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) |
|
AA418008 |
GFI1 |
Growth factor independent 1 |
|
H61188 |
SUV39H1 |
Suppressor of variegation 3-9 homolog 1 (Drosophila) |
|
H89996 |
CTCF |
CCCTC-binding factor (zinc finger protein) |
|
AA465369 |
TFDP2 |
Transcription factor Dp-2 (E2F dimerization partner 2) |
|
AA520999 |
CCNE2 |
Cyclin E2 |
|
AA160906 |
SIPA1 |
Signal-induced proliferation-associated gene 1 |
|
AA419251 |
IFITM1 |
Interferon-induced transmembrane protein 1 (9-27) |
|
AA058323 |
IFITM1 |
Interferon-induced transmembrane protein 1 (9-27) |
|
AA485371 |
BST2 |
Bone marrow stromal cell antigen 2 |
|
AA996024 |
HDAC4 |
Histone deacetylase 4 |
|
AA991578 |
VMD2 |
Vitelliform macular dystrophy (Best disease, bestrophin) |
|
W73810 |
EMP3 |
Epithelial membrane protein 3 |
|
AA010079 |
PRKR |
Protein kinase, interferon-inducible double-stranded RNA dependent |
|
AA469965 |
LCK |
Lymphocyte-specific protein tyrosine kinase |
|
AA464731 |
S100A11 |
S100 calcium binding protein A11 (calgizzarin) |
|
AA420981 |
LCK |
Lymphocyte-specific protein tyrosine kinase |
|
AA488332 |
PA2G4 |
Proliferation-associated 2G4, 38 kDa |
|
AA102526 |
IL8 |
Interleukin 8 |
|
AA496628 |
NME2 |
Nonmetastatic cells 2, protein (NM23B) expressed in |
|
AA933862 |
CD3E |
CD3E antigen, epsilon polypeptide (tit3 complex) |
|
AI341427 |
BCAT1 |
Branched chain aminotransferase 1, cytosolic |
|
N54821 |
IL2RG |
Interleukin 2 receptor, g (severe combined immunodeficiency) |
|
R39356 |
TP53 |
Tumor protein p53 (Li-Fraumeni syndrome) |
|
AA132086 |
C6orf108 |
Chromosome 6 open reading frame 108 |
|
R78608 |
CDK2AP1 |
CDK2-associated protein 1 |
|
AA644092 |
NME1 |
Nonmetastatic cells 1, protein (NM23A) expressed in |
|
AA973928 |
IGHMBP2 |
Immunoglobulin m binding protein 2 |
|
AA453749 |
HDGF |
Hepatoma-derived growth factor (high-mobility group protein 1-like) |
|
W69954 |
AIF1 |
Allograft inflammatory factor 1 |
|
AI872406 |
PFDN1 |
Prefoldin 1 |
|
N20996 |
NFIC |
Nuclear factor I/C (CCAAT-binding transcription factor) |
|
AA147594 |
TNFRSF8 |
Tumor necrosis factor receptor superfamily, member 8 |
|
AA504521 |
TLK1 |
Tousled-like kinase 1 |
|
AA490996 |
IFI16 |
Interferon, g -inducible protein 16 |
|
AA464600 |
MYC |
V-myc myelocytomatosis viral oncogene homolog (avian) |
|
AA482079 |
REPIN1 |
Replication initiator 1 |
|
AA285155 |
MCM5 |
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) |
|
N70057 |
LST1 |
Leukocyte specific transcript 1 |
|
AA496025 |
MCM7 |
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) |
|
W46439 |
TFDP1 |
Transcription factor Dp-1 |
|
AI417539 |
ZAK |
Sterile a motif and leucine zipper containing kinase AZK |
|
AA454813 |
IFRD2 |
Interferon-related developmental regulator 2 |
|
AA448261 |
HMGA1 |
High mobility group AT-hook 1 |
|
AA489619 |
USP16 |
Ubiquitin specific protease 16 |
|
AA463450 |
NBS1 |
Nijmegen breakage syndrome 1 (nibrin) |
|
AA427433 |
PPP2R1A |
Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform |
|
AA464256 |
DTYMK |
Deoxythymidylate kinase (thymidylate kinase) |
|
AA486790 |
CUL1 |
Cullin 1 |
|
AA496452 |
GRN |
Granulin |
|
AA149292 |
LIG3 |
Ligase III, DNA, ATP-dependent |
|
AA706968 |
ZWINT |
ZW10 interactor |
|
AA478268 |
CTBP1 |
C-terminal binding protein 1 |
|
AA683058 |
ZMYND11 |
Zinc finger, MYND domain containing 11 |
|
AA427767 |
RBM14 |
RNA binding motif protein 14 |
|
AA504204 |
POLD3 |
Polymerase (DNA-directed), d 3, accessory subunit |
|
AA130187 |
WT1 |
Wilms tumor 1 |
|
AA448664 |
POLE2 |
Polymerase (DNA directed), epsilon 2 (p59 subunit) |
|
AA504838 |
PMS1 |
PMS1 postmeiotic segregation increased 1 (S. cerevisiae) |
|
N21079 |
ZNF330 |
Zinc finger protein 330 |
|
AA456636 |
RAN |
RAN, member RAS oncogene family |
|
AA456608 |
MCM3 |
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) |
|
AA449048 |
ILF3 |
Interleukin enhancer binding factor 3, 90 kDa |
|
AA449762 |
ILF3 |
Interleukin enhancer binding factor 3, 90 kDa |
|
N29765 |
RAD51L3 |
RAD51-like 3 (S. cerevisiae) |
|
N69204 |
CSE1L |
CSE1 chromosome segregation 1-like (yeast) |
|
AA496253 |
ATF5 |
Activating transcription factor 5 |
Genes are listed in order from top to bottom as they appear in Fig. 11.