Table 3. Identities of genes in cell proliferation cluster

Accession no.

Gene symbol

Gene name

Up-regulated genes

R51580

NDN

Necdin homolog (mouse)

AA676797

CCNF

Cyclin F

W95001

CDC25C

Cell division cycle 25C

AI921113

HDAC5

Histone deacetylase 5

W80455

SLC12A6

Solute carrier family 12 (potassium/chloride transporters), member 6

AA400476

KIF2C

Kinesin family member 2C

AA284072

CDKN3

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

R16712

ANLN

Anillin, actin binding protein (scraps homolog, Drosophila)

R06254

TPD52L2

Tumor protein D52-like 2

AA705886

MXI1

MAX interactor 1

H59204

CDC6

CDC6 cell division cycle 6 homolog (Saccharomyces cerevisiae)

H82442

ID2

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

AA279658

TREX1

Three prime repair exonuclease 1

AA397813

CKS2

CDC28 protein kinase regulatory subunit 2

AA082943

CCNG1

Cyclin G1

H79779

HDAC3

Histone deacetylase 3

AI017242

DCTN3

Dynactin 3 (p22)

N72193

CETN2

Centrin, EF-hand protein, 2

T71991

CREG

Cellular repressor of E1A-stimulated genes

W93379

NEK2

NIMA (never in mitosis gene a)-related kinase 2

R43576

BLZF1

Basic leucine zipper nuclear factor 1 (JEM-1)

H59620

INSIG1

Insulin induced gene 1

AA496930

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs

AA464152

QSCN6

Quiescin Q6

AA157018

STIM1

Stromal interaction molecule 1

AA279804

RAP1A

RAP1A, member of RAS oncogene family

AA488168

DCTN1

Dynactin 1 (p150, glued homolog, Drosophila)

AA704693

SIRT2

Sirtuin (silent mating-type information regulation 2 homolog) 2 (S. cerevisiae)

AA447661

SESN1

Sestrin 1

AA775803

PRDX1

Peroxiredoxin 1

AA458870

CDC37

CDC37 cell division cycle 37 homolog (S. cerevisiae)

AA608576

MAPRE2

Microtubule-associated protein, RP/EB family, member 2

AI279078

GPR21

G protein-coupled receptor 21

AA676460

KPNA2

Karyopherin a 2 (RAG cohort 1, importin a 1)

AA489647

CCNG2

Cyclin G2

N26643

CDK2

Cyclin-dependent kinase 2

AA443347

SEPT8

Septin 8

AA903504

BLM

Bloom syndrome

AA129931

PPP1CC

Protein phosphatase 1, catalytic subunit, g isoform

AA775381

ORC4L

Origin recognition complex, subunit 4-like (yeast)

AA676705

CGRRF1

Cell growth regulator with ring finger domain 1

N70463

BTG1

B cell translocation gene 1, antiproliferative

AA489679

GRLF1

Glucocorticoid receptor DNA binding factor 1

H93424

APRIN

Androgen-induced proliferation inhibitor

R79935

TIEG

TGFB inducible early growth response

AA045731

TIEG

TGFB inducible early growth response

NM_170607

TCFL4

Transcription factor-like 4

R83380

STAMBP

STAM binding protein

AA778663

TNFSF9

Tumor necrosis factor (ligand) superfamily, member 9

AA482119

ID3

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

AA490213

TOB1

Transducer of ERBB2, 1

W93891

MTVR1

Mouse Mammary Turmor Virus Receptor homolog 1

H86558

MAD

MAX dimerization protein 1

H20743

CDC34

Cell division cycle 34

AA496147

TUSC2

Tumor suppressor candidate 2

M74093

CCNE1

Cyclin E1

N33574

ING1

Inhibitor of growth family, member 1

AA149095

DUSP1

Dual specificity phosphatase 1

H69583

BTG2

BTG family, member 2

AA866113

APBB2

Amyloid b (A4) precursor protein-binding, family B, member 2 (Fe65-like)

Down-regulated genes

 

AA774665

CCNB2

Cyclin B2

R19158

STK6

Serine/threonine kinase 6

H63492

STK6

Serine/threonine kinase 6

AA629262

PLK1

Polo-like kinase 1 (Drosophila)

AA046523

CETN3

Centrin, EF-hand protein, 3 (CDC31 homolog, yeast)

T54144

RIOK3

RIO kinase 3 (yeast)

N62245

CDC7

CDC7 cell division cycle 7 (S. cerevisiae)

AA215502

TUBE1

Tubulin, e 1

AI024518

SUV39H1

Suppressor of variegation 3-9 homolog 1 (Drosophila)

AA157787

KNTC1

Kinetochore associated 1

AA683102

RAD21

RAD21 homolog (Schizosaccharomyces pombe)

AA732873

PLK4

Polo-like kinase 4 (Drosophila)

AA678139

NUBP1

Nucleotide binding protein 1 (mind homolog, Escherichia coli)

AA609740

KATNA1

Katanin p60 (atpase-containing) subunit A 1

AA430504

UBE2C

Ubiquitin-conjugating enzyme E2C

AF208227

NCOA6

Nuclear receptor coactivator 6

AA496924

NF1

Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)

AA418008

GFI1

Growth factor independent 1

H61188

SUV39H1

Suppressor of variegation 3-9 homolog 1 (Drosophila)

H89996

CTCF

CCCTC-binding factor (zinc finger protein)

AA465369

TFDP2

Transcription factor Dp-2 (E2F dimerization partner 2)

AA520999

CCNE2

Cyclin E2

AA160906

SIPA1

Signal-induced proliferation-associated gene 1

AA419251

IFITM1

Interferon-induced transmembrane protein 1 (9-27)

AA058323

IFITM1

Interferon-induced transmembrane protein 1 (9-27)

AA485371

BST2

Bone marrow stromal cell antigen 2

AA996024

HDAC4

Histone deacetylase 4

AA991578

VMD2

Vitelliform macular dystrophy (Best disease, bestrophin)

W73810

EMP3

Epithelial membrane protein 3

AA010079

PRKR

Protein kinase, interferon-inducible double-stranded RNA dependent

AA469965

LCK

Lymphocyte-specific protein tyrosine kinase

AA464731

S100A11

S100 calcium binding protein A11 (calgizzarin)

AA420981

LCK

Lymphocyte-specific protein tyrosine kinase

AA488332

PA2G4

Proliferation-associated 2G4, 38 kDa

AA102526

IL8

Interleukin 8

AA496628

NME2

Nonmetastatic cells 2, protein (NM23B) expressed in

AA933862

CD3E

CD3E antigen, epsilon polypeptide (tit3 complex)

AI341427

BCAT1

Branched chain aminotransferase 1, cytosolic

N54821

IL2RG

Interleukin 2 receptor, g (severe combined immunodeficiency)

R39356

TP53

Tumor protein p53 (Li-Fraumeni syndrome)

AA132086

C6orf108

Chromosome 6 open reading frame 108

R78608

CDK2AP1

CDK2-associated protein 1

AA644092

NME1

Nonmetastatic cells 1, protein (NM23A) expressed in

AA973928

IGHMBP2

Immunoglobulin m binding protein 2

AA453749

HDGF

Hepatoma-derived growth factor (high-mobility group protein 1-like)

W69954

AIF1

Allograft inflammatory factor 1

AI872406

PFDN1

Prefoldin 1

N20996

NFIC

Nuclear factor I/C (CCAAT-binding transcription factor)

AA147594

TNFRSF8

Tumor necrosis factor receptor superfamily, member 8

AA504521

TLK1

Tousled-like kinase 1

AA490996

IFI16

Interferon, g -inducible protein 16

AA464600

MYC

V-myc myelocytomatosis viral oncogene homolog (avian)

AA482079

REPIN1

Replication initiator 1

AA285155

MCM5

MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)

N70057

LST1

Leukocyte specific transcript 1

AA496025

MCM7

MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)

W46439

TFDP1

Transcription factor Dp-1

AI417539

ZAK

Sterile a motif and leucine zipper containing kinase AZK

AA454813

IFRD2

Interferon-related developmental regulator 2

AA448261

HMGA1

High mobility group AT-hook 1

AA489619

USP16

Ubiquitin specific protease 16

AA463450

NBS1

Nijmegen breakage syndrome 1 (nibrin)

AA427433

PPP2R1A

Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform

AA464256

DTYMK

Deoxythymidylate kinase (thymidylate kinase)

AA486790

CUL1

Cullin 1

AA496452

GRN

Granulin

AA149292

LIG3

Ligase III, DNA, ATP-dependent

AA706968

ZWINT

ZW10 interactor

AA478268

CTBP1

C-terminal binding protein 1

AA683058

ZMYND11

Zinc finger, MYND domain containing 11

AA427767

RBM14

RNA binding motif protein 14

AA504204

POLD3

Polymerase (DNA-directed), d 3, accessory subunit

AA130187

WT1

Wilms tumor 1

AA448664

POLE2

Polymerase (DNA directed), epsilon 2 (p59 subunit)

AA504838

PMS1

PMS1 postmeiotic segregation increased 1 (S. cerevisiae)

N21079

ZNF330

Zinc finger protein 330

AA456636

RAN

RAN, member RAS oncogene family

AA456608

MCM3

MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)

AA449048

ILF3

Interleukin enhancer binding factor 3, 90 kDa

AA449762

ILF3

Interleukin enhancer binding factor 3, 90 kDa

N29765

RAD51L3

RAD51-like 3 (S. cerevisiae)

N69204

CSE1L

CSE1 chromosome segregation 1-like (yeast)

AA496253

ATF5

Activating transcription factor 5

Genes are listed in order from top to bottom as they appear in Fig. 11.