Category,ID,Name,Source,p-value,q-value Bonferroni,q-value FDR B&H,q-value FDR B&Y,Hit Count in Query List,Hit Count in Genome,Hit in Query List GO: Molecular Function,GO:0033549,MAP kinase phosphatase activity, ,1.16E-04,9.46E-02,4.12E-02,3.00E-01,4,19,"STYXL2,DUSP2,DUSP4,DUSP6" GO: Molecular Function,GO:0035259,nuclear glucocorticoid receptor binding, ,1.43E-04,1.17E-01,4.12E-02,3.00E-01,4,20,"ETS2,NR4A1,NR4A2,NR4A3" GO: Molecular Function,GO:0000981,"DNA-binding transcription factor activity, RNA polymerase II-specific", ,1.52E-04,1.24E-01,4.12E-02,3.00E-01,37,1427,"SOX4,ZNF136,MSC,ZNF154,ZNF184,ETS2,ETV5,NR4A1,KCNIP3,BBX,SP140L,HES1,ZNF160,FOXF1,ZNF367,ZNF680,FEZF2,FOSB,ZNF652,ZNF329,ZNF254,NR4A2,NR4A3,ZNF736,ZNF784,RFX3,SP110,TGIF1,NACC2,EGR1,EGR2,EGR4,ELF2,ZNF799,ZNF664,NPAS4,MYBL1" GO: Biological Process,GO:0048598,embryonic morphogenesis, ,2.01E-07,9.79E-04,9.79E-04,8.88E-03,39,1185,"SOX4,SPRY2,ATP6V0C,CENPF,MAPKAPK2,ZNF184,ETS2,ETV5,NCL,CITED2,ADM,DSTYK,BRPF1,FGF2,LBH,HES1,TMEM231,FOXF1,GPI,SHROOM3,SUPT20H,DUSP2,DUSP4,DUSP6,KAT6A,APEX1,CHSY1,LAMB3,NR4A3,LBR,EDN1,RIT1,TGIF1,LRIG1,EGR1,MICAL2,MYLIP,MACF1,RBM24" GO: Biological Process,GO:0007409,axonogenesis, ,1.05E-05,5.10E-02,1.41E-02,1.28E-01,25,705,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0007389,pattern specification process, ,1.33E-05,6.47E-02,1.41E-02,1.28E-01,29,903,"SPRY2,CENPF,ETS2,NCL,SLC25A25,B4GALT6,CITED2,BASP1,BRPF1,PXN,ARC,FGF2,HES1,COPS6,FOXF1,SEMA3F,SHROOM3,FEZF2,DUSP6,KAT6A,APEX1,CHSY1,RFX3,EDN1,TGIF1,FSTL1,EGR2,MICAL2,RBM24" GO: Biological Process,GO:0045934,negative regulation of nucleobase-containing compound metabolic process, ,1.46E-05,7.11E-02,1.41E-02,1.28E-01,46,1793,"ZNF136,MSC,CENPF,MAPKAPK2,NAB2,ETS2,LGR4,ETV5,PSMC5,U2AF2,KCNIP3,CITED2,UBR5,BASP1,TSPO,LBH,MCRS1,HES1,TAF1,FHL2,SMURF2,FOXF1,SMG6,SRSF6,FEZF2,FOSB,TENT5A,POT1,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2,RBM24" GO: Biological Process,GO:0003002,regionalization, ,1.59E-05,7.74E-02,1.41E-02,1.28E-01,23,632,"SPRY2,ETS2,SLC25A25,B4GALT6,CITED2,BASP1,BRPF1,PXN,ARC,FGF2,HES1,COPS6,FOXF1,SEMA3F,FEZF2,DUSP6,KAT6A,CHSY1,EDN1,TGIF1,FSTL1,EGR2,RBM24" GO: Biological Process,GO:0023057,negative regulation of signaling, ,1.76E-05,8.57E-02,1.41E-02,1.28E-01,45,1751,"SOX4,SPRY2,HLA-E,LGR4,GBP1,STYXL2,NCL,KCTD21,CHGA,RNF43,BDNF,ADM,SCG2,TSPO,ARC,FGF2,LBH,ARRDC3,DNM1,FHL2,SMURF2,DYRK3,DYRK2,RAF1,HTR1B,RASA3,DUSP2,DUSP4,DUSP6,NR4A2,STMN1,RGS2,LDLR,RGS4,CRHBP,EDN1,TXNDC12,TGIF1,CORO1A,EGR1,SUDS3,TLE4,SPRY4,MYLIP,CD59" GO: Biological Process,GO:0061564,axon development, ,2.03E-05,9.87E-02,1.41E-02,1.28E-01,26,780,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,TSPO,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0045744,negative regulation of G protein-coupled receptor signaling pathway, ,3.50E-05,1.70E-01,1.49E-02,1.35E-01,7,68,"ADM,ARRDC3,DNM1,HTR1B,STMN1,RGS2,RGS4" GO: Biological Process,GO:0010648,negative regulation of cell communication, ,3.60E-05,1.75E-01,1.49E-02,1.35E-01,44,1747,"SOX4,SPRY2,HLA-E,LGR4,GBP1,STYXL2,NCL,KCTD21,CHGA,RNF43,BDNF,ADM,SCG2,TSPO,ARC,FGF2,LBH,ARRDC3,DNM1,FHL2,SMURF2,DYRK3,DYRK2,RAF1,HTR1B,RASA3,DUSP2,DUSP4,DUSP6,NR4A2,STMN1,RGS2,RGS4,CRHBP,EDN1,TXNDC12,TGIF1,CORO1A,EGR1,SUDS3,TLE4,SPRY4,MYLIP,CD59" GO: Biological Process,GO:0048568,embryonic organ development, ,3.72E-05,1.81E-01,1.49E-02,1.35E-01,30,1005,"SOX4,SPRY2,ATP6V0C,CENPF,RNF112,ETV5,TUBB2B,NCL,CITED2,ADM,COX5A,DSTYK,TSPO,LBH,HES1,FOXF1,FLT3LG,KAT6A,APEX1,CHSY1,NR4A3,EDN1,RIT1,FSTL1,LRIG1,EGR1,EGR2,MICAL2,RBM24,PLK4" GO: Biological Process,GO:0009725,response to hormone, ,3.86E-05,1.87E-01,1.49E-02,1.35E-01,37,1370,"PCSK1,SERPINF1,NCL,NR4A1,SST,BDNF,EPM2AIP1,CITED2,ADM,PTPRN,UBR5,TSPO,PXN,LBH,TAC1,PLAT,HES1,FHL2,GPI,HTR1B,SRSF6,FOSB,SHC1,NR4A2,APEX1,NR4A3,PPAT,LDLR,CRHBP,EDN1,TXNDC12,CITED4,FADS1,EGR1,EGR2,RAB15,NPAS4" GO: Biological Process,GO:0043435,response to corticotropin-releasing hormone, ,4.64E-05,2.25E-01,1.49E-02,1.35E-01,3,6,"NR4A1,NR4A2,NR4A3" GO: Biological Process,GO:0071376,cellular response to corticotropin-releasing hormone stimulus, ,4.64E-05,2.25E-01,1.49E-02,1.35E-01,3,6,"NR4A1,NR4A2,NR4A3" GO: Biological Process,GO:0060562,epithelial tube morphogenesis, ,4.80E-05,2.33E-01,1.49E-02,1.35E-01,21,587,"SOX4,SPRY2,CENPF,LGR4,ETV5,NCL,CITED2,ADM,BRPF1,PXN,FGF2,HES1,FOXF1,SHROOM3,RASA3,PODXL,APEX1,EDN1,TGIF1,MICAL2,RBM24" GO: Biological Process,GO:0098916,anterograde trans-synaptic signaling, ,5.33E-05,2.59E-01,1.49E-02,1.35E-01,30,1025,"GJD2,PDYN,ETV5,PSMC5,TUBB2B,NR4A1,SST,STX1B,BDNF,PLPPR4,ARC,SYT1,SYT5,TAC1,PLAT,DNM1,PMP22,CACNB1,NPTX2,HTR1B,RGS4,CRHBP,EDN1,OPHN1,EGR1,EGR2,RAB15,SNAP25,NPAS4,HCRTR2" GO: Biological Process,GO:0007268,chemical synaptic transmission, ,5.33E-05,2.59E-01,1.49E-02,1.35E-01,30,1025,"GJD2,PDYN,ETV5,PSMC5,TUBB2B,NR4A1,SST,STX1B,BDNF,PLPPR4,ARC,SYT1,SYT5,TAC1,PLAT,DNM1,PMP22,CACNB1,NPTX2,HTR1B,RGS4,CRHBP,EDN1,OPHN1,EGR1,EGR2,RAB15,SNAP25,NPAS4,HCRTR2" GO: Biological Process,GO:0000904,cell morphogenesis involved in differentiation, ,5.81E-05,2.82E-01,1.49E-02,1.35E-01,31,1081,"MATN2,LGR4,ETV5,GBP1,TUBB2B,B4GALT6,BDNF,TMEFF2,ANOS1,DST,METRN,PLPPR4,PXN,ARC,HES1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,SPRY4,MACF1,SNAP25" GO: Biological Process,GO:0007616,long-term memory, ,6.00E-05,2.92E-01,1.49E-02,1.35E-01,6,51,"ARC,TAC1,LDLR,EGR1,SNAP25,NPAS4" GO: Biological Process,GO:0048667,cell morphogenesis involved in neuron differentiation, ,6.09E-05,2.96E-01,1.49E-02,1.35E-01,27,882,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,HES1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0099537,trans-synaptic signaling, ,6.13E-05,2.98E-01,1.49E-02,1.35E-01,30,1033,"GJD2,PDYN,ETV5,PSMC5,TUBB2B,NR4A1,SST,STX1B,BDNF,PLPPR4,ARC,SYT1,SYT5,TAC1,PLAT,DNM1,PMP22,CACNB1,NPTX2,HTR1B,RGS4,CRHBP,EDN1,OPHN1,EGR1,EGR2,RAB15,SNAP25,NPAS4,HCRTR2" GO: Biological Process,GO:0051253,negative regulation of RNA metabolic process, ,8.67E-05,4.21E-01,1.96E-02,1.78E-01,41,1645,"ZNF136,MSC,CENPF,MAPKAPK2,NAB2,ETS2,LGR4,ETV5,PSMC5,U2AF2,KCNIP3,CITED2,BASP1,LBH,HES1,TAF1,FHL2,SMURF2,FOXF1,SRSF6,FEZF2,FOSB,TENT5A,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2,RBM24" GO: Biological Process,GO:0009968,negative regulation of signal transduction, ,8.87E-05,4.31E-01,1.96E-02,1.78E-01,40,1591,"SOX4,SPRY2,HLA-E,LGR4,GBP1,STYXL2,NCL,KCTD21,RNF43,BDNF,ADM,SCG2,FGF2,LBH,ARRDC3,DNM1,FHL2,SMURF2,DYRK3,DYRK2,RAF1,HTR1B,RASA3,DUSP2,DUSP4,DUSP6,NR4A2,STMN1,RGS2,RGS4,CRHBP,TXNDC12,TGIF1,CORO1A,EGR1,SUDS3,TLE4,SPRY4,MYLIP,CD59" GO: Biological Process,GO:0099536,synaptic signaling, ,9.89E-05,4.81E-01,2.09E-02,1.90E-01,30,1061,"GJD2,PDYN,ETV5,PSMC5,TUBB2B,NR4A1,SST,STX1B,BDNF,PLPPR4,ARC,SYT1,SYT5,TAC1,PLAT,DNM1,PMP22,CACNB1,NPTX2,HTR1B,RGS4,CRHBP,EDN1,OPHN1,EGR1,EGR2,RAB15,SNAP25,NPAS4,HCRTR2" GO: Biological Process,GO:0048646,anatomical structure formation involved in morphogenesis, ,1.10E-04,5.34E-01,2.23E-02,2.02E-01,45,1890,"SOX4,SPRY2,GJD2,SERPINF1,HLA-E,ETS2,ETV5,STYXL2,NCL,NR4A1,CITED2,ADM,LYVE1,SCG2,BRPF1,PXN,FGF2,MCRS1,HES1,FHL2,FOXF1,PMP22,DOCK2,GPI,FLT3LG,SHROOM3,PODXL,DUSP2,DUSP4,DUSP6,KAT6A,SHC1,CHSY1,LAMB3,NR4A3,RGS2,EDN1,OPHN1,TGIF1,EGR2,SPRY4,CD59,MACF1,FUT1,RBM24" GO: Biological Process,GO:0048729,tissue morphogenesis, ,1.34E-04,6.52E-01,2.61E-02,2.36E-01,31,1132,"SOX4,SPRY2,CENPF,MAPKAPK2,LGR4,ETV5,NCL,TMEFF2,CITED2,ADM,BRPF1,PXN,FGF2,HES1,COPS6,SMURF2,FOXF1,GPI,SHROOM3,RASA3,PODXL,PLEKHA4,APEX1,CHSY1,NR4A3,EDN1,OPHN1,TGIF1,MICAL2,MACF1,RBM24" GO: Biological Process,GO:0031175,neuron projection development, ,1.47E-04,7.13E-01,2.72E-02,2.47E-01,36,1407,"MATN2,SERPINF1,HLA-E,LGR4,ETV5,TUBB2B,STX1B,B4GALT6,BDNF,ADM,ANOS1,DST,METRN,PLPPR4,TSPO,ARC,SYT1,HES1,PMP22,SEMA3F,FEZF2,SHC1,NR4A2,LAMB3,NR4A3,STMN1,RGS2,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MYLIP,MACF1,SNAP25" GO: Biological Process,GO:0048812,neuron projection morphogenesis, ,1.51E-04,7.35E-01,2.72E-02,2.47E-01,27,932,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,SYT1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:1901652,response to peptide, ,1.61E-04,7.82E-01,2.77E-02,2.51E-01,24,785,"PCSK1,SERPINF1,NCL,NR4A1,EPM2AIP1,ADM,PTPRN,PXN,PLAT,DNM1,CACNB1,SRSF6,SHC1,NR4A2,APEX1,NR4A3,PPAT,LDLR,CRHBP,EDN1,FADS1,EGR1,EGR2,RAB15" GO: Biological Process,GO:0014072,response to isoquinoline alkaloid, ,1.65E-04,8.03E-01,2.77E-02,2.51E-01,6,61,"PCSK1,TAC1,GPI,FOSB,RGS4,EGR1" GO: Biological Process,GO:0032940,secretion by cell, ,1.77E-04,8.61E-01,2.85E-02,2.58E-01,30,1097,"PCSK1,SOX4,MYO1G,PDYN,HLA-E,CHGA,NR4A1,STX1B,BDNF,ADM,PTPRN,SCG2,HYAL3,TSPO,SYT1,SYT5,TAC1,FOXF1,RAF1,HTR1B,NR4A3,RFX3,CRHBP,EDN1,ARL4D,CORO1A,SYNGR3,AACS,RAB15,SNAP25" GO: Biological Process,GO:1900924,negative regulation of glycine import across plasma membrane, ,1.82E-04,8.84E-01,2.85E-02,2.58E-01,2,2,"RGS2,RGS4" GO: Biological Process,GO:0045944,positive regulation of transcription by RNA polymerase II, ,1.93E-04,9.39E-01,2.93E-02,2.66E-01,36,1427,"SOX4,ETS2,ETV5,IER5,NCL,SSBP2,NR4A1,CITED2,PTPRN,FGF2,MCRS1,HES1,TAF1,MED17,FOXF1,RAF1,FLT3LG,SUPT20H,FEZF2,FOSB,TNIP2,KAT6A,NR4A2,APEX1,NR4A3,ZNF784,RFX3,EDN1,IFRD1,EGR1,EGR2,EGR4,MICAL2,HELZ2,NPAS4,MYBL1" GO: Biological Process,GO:0007369,gastrulation, ,2.01E-04,9.77E-01,2.94E-02,2.67E-01,16,422,"MAPKAPK2,ZNF184,ETS2,ETV5,FOXF1,GPI,SUPT20H,DUSP2,DUSP4,DUSP6,LAMB3,NR4A3,LBR,TGIF1,MYLIP,MACF1" GO: Biological Process,GO:0120039,plasma membrane bounded cell projection morphogenesis, ,2.06E-04,1.00E+00,2.94E-02,2.67E-01,27,950,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,SYT1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0001975,response to amphetamine, ,2.16E-04,1.00E+00,3.00E-02,2.72E-01,6,64,"NR4A1,NR4A2,RGS2,RGS4,EDN1,EGR1" GO: Biological Process,GO:0048791,calcium ion-regulated exocytosis of neurotransmitter, ,2.30E-04,1.00E+00,3.01E-02,2.73E-01,4,23,"STX1B,SYT1,SYT5,SNAP25" GO: Biological Process,GO:0048858,cell projection morphogenesis, ,2.35E-04,1.00E+00,3.01E-02,2.73E-01,27,958,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,SYT1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0040036,regulation of fibroblast growth factor receptor signaling pathway, ,2.35E-04,1.00E+00,3.01E-02,2.73E-01,6,65,"SPRY2,DSTYK,FGF2,DUSP4,DUSP6,SPRY4" GO: Biological Process,GO:0140352,export from cell, ,2.47E-04,1.00E+00,3.03E-02,2.75E-01,31,1172,"PCSK1,SOX4,MYO1G,PDYN,HLA-E,CHGA,NR4A1,STX1B,BDNF,ADM,KCNE4,PTPRN,SCG2,HYAL3,TSPO,SYT1,SYT5,TAC1,FOXF1,RAF1,HTR1B,NR4A3,RFX3,CRHBP,EDN1,ARL4D,CORO1A,SYNGR3,AACS,RAB15,SNAP25" GO: Biological Process,GO:0071363,cellular response to growth factor stimulus, ,2.55E-04,1.00E+00,3.03E-02,2.75E-01,27,963,"SPRY2,MAPKAPK2,NCL,NR4A1,B4GALT6,BDNF,CITED2,DSTYK,PXN,FGF2,TAC1,HES1,SMURF2,RAF1,DUSP4,DUSP6,SHC1,EDN1,TGIF1,CORO1A,FSTL1,EGR1,EGR4,SUDS3,SPRY4,CD59,CEP57" GO: Biological Process,GO:0045055,regulated exocytosis, ,2.60E-04,1.00E+00,3.03E-02,2.75E-01,14,346,"HLA-E,CHGA,STX1B,HYAL3,SYT1,SYT5,FOXF1,HTR1B,NR4A3,CRHBP,CORO1A,SYNGR3,RAB15,SNAP25" GO: Biological Process,GO:0002009,morphogenesis of an epithelium, ,2.68E-04,1.00E+00,3.03E-02,2.75E-01,27,966,"SOX4,SPRY2,CENPF,MAPKAPK2,LGR4,ETV5,NCL,TMEFF2,CITED2,ADM,BRPF1,PXN,FGF2,HES1,COPS6,SMURF2,FOXF1,SHROOM3,RASA3,PODXL,PLEKHA4,APEX1,EDN1,OPHN1,TGIF1,MICAL2,RBM24" GO: Biological Process,GO:2000026,regulation of multicellular organismal development, ,2.69E-04,1.00E+00,3.03E-02,2.75E-01,44,1908,"SOX4,SPRY2,BRPF3,RNF112,SERPINF1,HLA-E,ETV5,SYNDIG1,BDNF,ITPKB,CITED2,ADM,METRN,BASP1,TMEM178A,SCG2,BRPF1,TSPO,PXN,FGF2,MCRS1,HES1,AMIGO2,SEMA3F,FLT3LG,SRSF6,FEZF2,TENT5A,DUSP6,KAT6A,SHC1,RFX3,RGS2,LDLR,RGS4,S1PR3,EDN1,PRMT6,TGIF1,IFRD1,EGR2,CD59,MACF1,FUT1" GO: Biological Process,GO:0001704,formation of primary germ layer, ,2.80E-04,1.00E+00,3.09E-02,2.80E-01,10,192,"ETS2,ETV5,FOXF1,GPI,DUSP2,DUSP4,DUSP6,LAMB3,NR4A3,MACF1" GO: Biological Process,GO:0043279,response to alkaloid, ,3.04E-04,1.00E+00,3.28E-02,2.97E-01,10,194,"PCSK1,BDNF,TAC1,HES1,GPI,HTR1B,FOSB,RGS4,CRHBP,EGR1" GO: Biological Process,GO:0043434,response to peptide hormone, ,3.43E-04,1.00E+00,3.49E-02,3.17E-01,21,677,"PCSK1,NCL,NR4A1,EPM2AIP1,ADM,PTPRN,PXN,PLAT,SRSF6,SHC1,NR4A2,APEX1,NR4A3,PPAT,LDLR,CRHBP,EDN1,FADS1,EGR1,EGR2,RAB15" GO: Biological Process,GO:0060548,negative regulation of cell death, ,3.43E-04,1.00E+00,3.49E-02,3.17E-01,34,1359,"SOX4,SPRY2,ATP6V0C,SERPINF1,HLA-E,PSMC5,NCL,CHGA,NR4A1,BDNF,ITPKB,CITED2,SCG2,DSTYK,CIAPIN1,FGF2,TAC1,FHL2,AMIGO2,DYRK3,GPI,RAF1,FLT3LG,SRSF6,TNIP2,SHC1,NR4A2,APEX1,NR4A3,EDN1,TXNDC12,CORO1A,FSTL1,CD59" GO: Biological Process,GO:0032989,cellular component morphogenesis, ,3.45E-04,1.00E+00,3.49E-02,3.17E-01,30,1141,"GJD2,MATN2,LGR4,ETV5,STYXL2,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,SYT1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25,RBM24" GO: Biological Process,GO:0032990,cell part morphogenesis, ,3.53E-04,1.00E+00,3.49E-02,3.17E-01,27,983,"MATN2,LGR4,ETV5,TUBB2B,B4GALT6,BDNF,ANOS1,DST,METRN,PLPPR4,ARC,SYT1,PMP22,SEMA3F,FEZF2,NR4A2,LAMB3,NR4A3,STMN1,RGS4,EDN1,OPHN1,CORO1A,IFRD1,EGR2,MACF1,SNAP25" GO: Biological Process,GO:0044351,macropinocytosis, ,3.64E-04,1.00E+00,3.49E-02,3.17E-01,3,11,"MAPKAPK2,STX1B,DOCK2" GO: Biological Process,GO:0008277,regulation of G protein-coupled receptor signaling pathway, ,3.67E-04,1.00E+00,3.49E-02,3.17E-01,9,163,"CHGA,ADM,ARRDC3,DNM1,HTR1B,STMN1,RGS2,RGS4,EDN1" GO: Biological Process,GO:0048844,artery morphogenesis, ,4.53E-04,1.00E+00,4.18E-02,3.79E-01,7,102,"SOX4,CITED2,HES1,FOXF1,KAT6A,LDLR,EDN1" GO: Biological Process,GO:1903508,positive regulation of nucleic acid-templated transcription, ,4.72E-04,1.00E+00,4.18E-02,3.79E-01,43,1900,"SOX4,ETS2,LGR4,ETV5,PSMC5,IER5,NCL,SSBP2,NR4A1,CITED2,PTPRN,BRPF1,FGF2,LBH,MCRS1,HES1,TAF1,MED17,FOXF1,RAF1,FLT3LG,SUPT20H,FEZF2,FOSB,TNIP2,KAT6A,SHC1,NR4A2,APEX1,NR4A3,ZNF784,RFX3,EDN1,IFRD1,CITED4,EGR1,EGR2,EGR4,MICAL2,HELZ2,ELF2,NPAS4,MYBL1" GO: Biological Process,GO:0045893,positive regulation of DNA-templated transcription, ,4.72E-04,1.00E+00,4.18E-02,3.79E-01,43,1900,"SOX4,ETS2,LGR4,ETV5,PSMC5,IER5,NCL,SSBP2,NR4A1,CITED2,PTPRN,BRPF1,FGF2,LBH,MCRS1,HES1,TAF1,MED17,FOXF1,RAF1,FLT3LG,SUPT20H,FEZF2,FOSB,TNIP2,KAT6A,SHC1,NR4A2,APEX1,NR4A3,ZNF784,RFX3,EDN1,IFRD1,CITED4,EGR1,EGR2,EGR4,MICAL2,HELZ2,ELF2,NPAS4,MYBL1" GO: Biological Process,GO:0045892,negative regulation of DNA-templated transcription, ,4.78E-04,1.00E+00,4.18E-02,3.79E-01,36,1497,"ZNF136,MSC,CENPF,NAB2,ETS2,LGR4,ETV5,PSMC5,KCNIP3,CITED2,BASP1,LBH,HES1,TAF1,FHL2,SMURF2,FOXF1,FEZF2,FOSB,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2" GO: Biological Process,GO:1903507,negative regulation of nucleic acid-templated transcription, ,4.96E-04,1.00E+00,4.18E-02,3.79E-01,36,1500,"ZNF136,MSC,CENPF,NAB2,ETS2,LGR4,ETV5,PSMC5,KCNIP3,CITED2,BASP1,LBH,HES1,TAF1,FHL2,SMURF2,FOXF1,FEZF2,FOSB,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2" GO: Biological Process,GO:0070848,response to growth factor, ,5.03E-04,1.00E+00,4.18E-02,3.79E-01,27,1006,"SPRY2,MAPKAPK2,NCL,NR4A1,B4GALT6,BDNF,CITED2,DSTYK,PXN,FGF2,TAC1,HES1,SMURF2,RAF1,DUSP4,DUSP6,SHC1,EDN1,TGIF1,CORO1A,FSTL1,EGR1,EGR4,SUDS3,SPRY4,CD59,CEP57" GO: Biological Process,GO:1902680,positive regulation of RNA biosynthetic process, ,5.04E-04,1.00E+00,4.18E-02,3.79E-01,43,1906,"SOX4,ETS2,LGR4,ETV5,PSMC5,IER5,NCL,SSBP2,NR4A1,CITED2,PTPRN,BRPF1,FGF2,LBH,MCRS1,HES1,TAF1,MED17,FOXF1,RAF1,FLT3LG,SUPT20H,FEZF2,FOSB,TNIP2,KAT6A,SHC1,NR4A2,APEX1,NR4A3,ZNF784,RFX3,EDN1,IFRD1,CITED4,EGR1,EGR2,EGR4,MICAL2,HELZ2,ELF2,NPAS4,MYBL1" GO: Biological Process,GO:0010558,negative regulation of macromolecule biosynthetic process, ,5.07E-04,1.00E+00,4.18E-02,3.79E-01,42,1848,"ZNF136,MSC,CENPF,NAB2,ETS2,LGR4,ETV5,PSMC5,NCL,KCNIP3,TMEFF2,CITED2,BASP1,LBH,MCRS1,HES1,TAF1,FHL2,SMURF2,FOXF1,FEZF2,FOSB,POT1,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,RGS2,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2,RBM24" GO: Biological Process,GO:1902679,negative regulation of RNA biosynthetic process, ,5.21E-04,1.00E+00,4.22E-02,3.83E-01,36,1504,"ZNF136,MSC,CENPF,NAB2,ETS2,LGR4,ETV5,PSMC5,KCNIP3,CITED2,BASP1,LBH,HES1,TAF1,FHL2,SMURF2,FOXF1,FEZF2,FOSB,KAT6A,ZNF254,SHC1,NR4A2,APEX1,NR4A3,ZNF736,ZNF784,RFX3,EDN1,PRMT6,TGIF1,NACC2,EGR1,SUDS3,TLE4,ELF2" GO: Biological Process,GO:1900923,regulation of glycine import across plasma membrane, ,5.33E-04,1.00E+00,4.25E-02,3.85E-01,2,3,"RGS2,RGS4" GO: Biological Process,GO:0042063,gliogenesis, ,5.42E-04,1.00E+00,4.25E-02,3.85E-01,17,508,"SOX4,MATN2,RNF112,NAB2,ETV5,B4GALT6,METRN,TSPO,NAV1,FGF2,HES1,PMP22,LDLR,PRMT6,IFRD1,EGR1,EGR2" GO: Biological Process,GO:0010243,response to organonitrogen compound, ,5.51E-04,1.00E+00,4.25E-02,3.85E-01,38,1623,"PCSK1,SERPINF1,NCL,NR4A1,SST,BDNF,EPM2AIP1,ADM,PTPRN,TSPO,PXN,TAC1,PLAT,HES1,TAF1,DNM1,GPI,CACNB1,HTR1B,SRSF6,FOSB,SHC1,NR4A2,APEX1,NR4A3,PPAT,RGS2,LDLR,RGS4,CRHBP,EDN1,TXNDC12,FADS1,EGR1,EGR2,MYLIP,AACS,RAB15" GO: Biological Process,GO:0007611,learning or memory, ,6.28E-04,1.00E+00,4.77E-02,4.32E-01,14,378,"SERPINF1,BDNF,C1QL1,ARC,TAC1,GPI,NPTX2,NR4A2,LDLR,CRHBP,EGR1,EGR2,SNAP25,NPAS4" GO: Biological Process,GO:0030177,positive regulation of Wnt signaling pathway, ,6.66E-04,1.00E+00,4.98E-02,4.52E-01,9,177,"SOX4,ATP6V0C,TMEM198,LGR4,UBR5,FGF2,SMURF2,PLEKHA4,MACF1" GO: Cellular Component,GO:0031045,dense core granule, ,3.96E-07,2.38E-04,2.38E-04,1.66E-03,7,36,"PDYN,CHGA,SCG2,SYT1,SYT5,PLAT,CRHBP" GO: Cellular Component,GO:0098992,neuronal dense core vesicle, ,1.52E-06,9.12E-04,4.56E-04,3.18E-03,5,16,"PDYN,CHGA,SCG2,SYT5,PLAT" GO: Cellular Component,GO:0030133,transport vesicle, ,3.50E-06,2.10E-03,7.00E-04,4.89E-03,22,541,"PCSK1,PCSK2,ATP6V0C,RNF112,PDYN,HLA-E,SYNDIG1,CHGA,STX1B,BDNF,PTPRN,SYT1,SYT5,DCLK2,DNM1,EDN1,OVGP1,SYNGR3,CD59,RAB15,SNAP25,MX1" GO: Cellular Component,GO:0045202,synapse, ,1.04E-05,6.22E-03,1.56E-03,1.09E-02,44,1683,"PCSK1,ATP6V0C,GJD2,RNF112,PDYN,ETV5,PSMC5,SYNDIG1,TUBB2B,NR4A1,SST,KCNIP3,STX1B,BDNF,C1QL1,DST,PLPPR4,PTPRN,KCNK1,STRN4,ARC,SYT1,SYT5,TAC1,PLAT,DCLK2,DNM1,CNN3,PMP22,SEMA3F,CACNB1,NPTX2,HTR1B,SYNM,CRHBP,TRIM3,OPHN1,CORO1A,SYNGR3,MACF1,RAB15,SNAP25,NPAS4,HCRTR2" GO: Cellular Component,GO:0008021,synaptic vesicle, ,1.95E-05,1.17E-02,2.34E-03,1.63E-02,14,275,"ATP6V0C,RNF112,PDYN,SYNDIG1,STX1B,BDNF,PTPRN,SYT1,SYT5,DCLK2,DNM1,SYNGR3,RAB15,SNAP25" GO: Cellular Component,GO:0070382,exocytic vesicle, ,3.56E-05,2.14E-02,3.57E-03,2.49E-02,15,329,"ATP6V0C,RNF112,PDYN,SYNDIG1,STX1B,BDNF,PTPRN,SYT1,SYT5,DCLK2,DNM1,SYNGR3,RAB15,SNAP25,MX1" GO: Cellular Component,GO:0070776,MOZ/MORF histone acetyltransferase complex, ,1.82E-04,1.09E-01,1.44E-02,1.01E-01,3,9,"BRPF3,BRPF1,KAT6A" GO: Cellular Component,GO:0099503,secretory vesicle, ,2.11E-04,1.27E-01,1.44E-02,1.01E-01,32,1232,"A1BG,PCSK1,PCSK2,ATP6V0C,RNF112,PDYN,SYNDIG1,CHGA,CHGB,STX1B,BDNF,PTPRN,SCG2,HYAL3,ARC,SYT1,SYT5,PLAT,DCLK2,DNM1,DOCK2,GPI,VWF,CCT2,CRHBP,EDN1,SYNGR3,CD59,SERPINB1,RAB15,SNAP25,MX1" GO: Cellular Component,GO:0098793,presynapse, ,2.16E-04,1.30E-01,1.44E-02,1.01E-01,22,712,"PCSK1,ATP6V0C,RNF112,PDYN,SYNDIG1,NR4A1,KCNIP3,STX1B,BDNF,C1QL1,PTPRN,SYT1,SYT5,DCLK2,DNM1,CACNB1,HTR1B,CRHBP,OPHN1,SYNGR3,RAB15,SNAP25" GO: Cellular Component,GO:0070775,H3 histone acetyltransferase complex, ,2.57E-04,1.54E-01,1.54E-02,1.08E-01,3,10,"BRPF3,BRPF1,KAT6A" Domain,IPR018054,Chromogranin_CS,InterPro,3.10E-06,4.66E-03,9.31E-04,7.35E-03,3,3,"CHGA,CHGB,SCG2" Domain,IPR003070,Nuc_orph_rcpt,InterPro,3.10E-06,4.66E-03,9.31E-04,7.35E-03,3,3,"NR4A1,NR4A2,NR4A3" Domain,PF01271,Granin,Pfam,3.10E-06,4.66E-03,9.31E-04,7.35E-03,3,3,"CHGA,CHGB,SCG2" Domain,PS00422,GRANINS_1,PROSITE,3.10E-06,4.66E-03,9.31E-04,7.35E-03,3,3,"CHGA,CHGB,SCG2" Domain,IPR001990,Granin,InterPro,3.10E-06,4.66E-03,9.31E-04,7.35E-03,3,3,"CHGA,CHGB,SCG2" Domain,IPR001819,Chromogranin_AB,InterPro,2.14E-04,3.22E-01,4.33E-02,3.41E-01,2,2,"CHGA,CHGB" Domain,PS00423,GRANINS_2,PROSITE,2.14E-04,3.22E-01,4.33E-02,3.41E-01,2,2,"CHGA,CHGB" Domain,PS50014,BROMODOMAIN_2,PROSITE,3.08E-04,4.63E-01,4.33E-02,3.41E-01,5,41,"BRPF3,SP140L,BRPF1,TAF1,SP110" Domain,IPR008343,MKP,InterPro,3.40E-04,5.10E-01,4.33E-02,3.41E-01,3,10,"DUSP2,DUSP4,DUSP6" Domain,IPR001487,Bromodomain,InterPro,3.46E-04,5.19E-01,4.33E-02,3.41E-01,5,42,"BRPF3,SP140L,BRPF1,TAF1,SP110" Domain,SM00297,BROMO,SMART,3.46E-04,5.19E-01,4.33E-02,3.41E-01,5,42,"BRPF3,SP140L,BRPF1,TAF1,SP110" Domain,1.20.920.10,-,Gene3D,3.46E-04,5.19E-01,4.33E-02,3.41E-01,5,42,"BRPF3,SP140L,BRPF1,TAF1,SP110" Pathway,M42557,Orexin receptor pathway,MSigDB C2 BIOCARTA (v7.5.1),5.10E-07,8.39E-04,8.39E-04,6.70E-03,13,154,"NR4A1,ARC,HES1,FOSB,TENT5A,DUSP4,NR4A3,LDLR,EGR1,EGR2,PDP1,NPAS4,HCRTR2" Transcription Factor Binding Site,V$CREBP1_Q2,V$CREBP1_Q2,TFBS,3.07E-15,3.01E-12,3.01E-12,2.25E-11,21,196,"PCSK1,ATP6V0C,ZNF184,CHGB,SLC25A25,SCG2,KCNK1,CHPF,HS3ST2,ZNF367,GPR3,FOSB,RBMS2,NR4A2,NR4A3,EGR1,EGR2,EGR4,PDP1,SYNGR3,SNAP25" Transcription Factor Binding Site,V$CREB_Q4_01,V$CREB_Q4_01,TFBS,4.16E-13,4.08E-10,2.04E-10,1.52E-09,18,171,"ATP6V0C,ZNF184,CHGB,SST,SLC25A25,SCG2,CHPF,HS3ST2,ZNF367,GPR3,FOSB,RBMS2,NR4A2,EGR2,PDP1,SYNGR3,SNAP25,PLK4" Transcription Factor Binding Site,V$CREB_Q4,V$CREB_Q4,TFBS,7.70E-13,7.54E-10,2.52E-10,1.88E-09,19,203,"PCSK1,ATP6V0C,ZNF184,CHGB,SST,SCG2,CHPF,HS3ST2,ZNF367,GPR3,FOSB,RBMS2,NR4A2,NR4A3,EGR4,PDP1,SYNGR3,SNAP25,PLK4" Transcription Factor Binding Site,V$CREB_01,V$CREB_01,TFBS,1.67E-12,1.64E-09,4.10E-10,3.06E-09,19,212,"PCSK1,ATP6V0C,ZNF184,CHGB,SST,SLC25A25,KCNF1,SCG2,CHPF,HS3ST2,ZNF367,GPR3,FOSB,RBMS2,NR4A2,PDP1,SYNGR3,SNAP25,PLK4" Transcription Factor Binding Site,V$E4F1_Q6,V$E4F1_Q6,TFBS,3.50E-12,3.43E-09,6.87E-10,5.13E-09,19,221,"ATP6V0C,ZNF184,CHGB,NR4A1,SLC25A25,SCG2,CHPF,ZNF367,GPR3,FOSB,RBMS2,NR4A2,NR4A3,MIR137HG,EGR2,EGR4,PDP1,SYNGR3,PLK4" Transcription Factor Binding Site,V$CREB_Q2,V$CREB_Q2,TFBS,1.09E-11,1.07E-08,1.78E-09,1.33E-08,18,207,"PCSK1,ATP6V0C,ZNF184,CHGB,SST,SCG2,CHPF,HS3ST2,ZNF367,FOSB,RBMS2,NR4A2,NR4A3,EGR1,EGR4,PDP1,SYNGR3,PLK4" Transcription Factor Binding Site,V$CREBP1CJUN_01,V$CREBP1CJUN_01,TFBS,1.75E-11,1.72E-08,2.46E-09,1.83E-08,18,213,"PCSK1,ATP6V0C,ZNF184,CHGB,SST,SLC25A25,KCNF1,SCG2,CHPF,HS3ST2,ZNF367,GPR3,NR4A2,EGR1,PDP1,SYNGR3,SNAP25,HCRTR2" Transcription Factor Binding Site,TGACGTCA_V$ATF3_Q6,TGACGTCA_V$ATF3_Q6,TFBS,2.15E-10,2.10E-07,2.63E-08,1.96E-07,16,188,"PCSK1,ATP6V0C,ZNF184,CHGB,SST,SLC25A25,KCNF1,SCG2,CHPF,HS3ST2,ZNF367,GPR3,NR4A2,PDP1,SYNGR3,SNAP25" Transcription Factor Binding Site,V$ATF_01,V$ATF_01,TFBS,1.37E-08,1.35E-05,1.50E-06,1.12E-05,15,217,"ATP6V0C,ZNF184,CHGB,SST,SLC25A25,SCG2,CHPF,HS3ST2,ZNF367,GPR3,FOSB,DUSP4,NR4A2,EGR2,EGR4" Transcription Factor Binding Site,GTGACGY_V$E4F1_Q6,GTGACGY_V$E4F1_Q6,TFBS,2.22E-08,2.17E-05,2.17E-06,1.62E-05,22,496,"PCSK2,ATP6V0C,NAB2,ZNF184,CHGB,NR4A1,SLC25A25,SCG2,CHPF,ZNF367,GPR3,FOSB,RBMS2,DUSP4,NR4A2,NR4A3,EGR1,EGR2,EGR4,PDP1,SYNGR3,PLK4" Transcription Factor Binding Site,TGAYRTCA_V$ATF3_Q6,TGAYRTCA_V$ATF3_Q6,TFBS,4.56E-08,4.47E-05,3.77E-06,2.82E-05,20,430,"PCSK1,PCSK2,ATP6V0C,ZNF184,CHGB,SST,SLC25A25,KCNF1,SCG2,KCNK1,CHPF,HS3ST2,CNN3,ZNF367,GPR3,NR4A2,PDP1,CELF3,SYNGR3,SNAP25" Transcription Factor Binding Site,CAGGTG_V$E12_Q6,CAGGTG_V$E12_Q6,TFBS,4.62E-08,4.52E-05,3.77E-06,2.82E-05,48,1950,"SOX4,SPRY2,ATP6V0C,MSC,PDYN,ETS2,SSBP2,ZNF385B,NR4A1,B4GALT6,BDNF,TMEFF2,CITED2,BBX,SCG2,KCNK1,STRN4,SYT1,TAC1,ARRDC3,FAM181B,SMURF2,PMP22,SEMA3F,NPTX2,VWF,PODXL,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,LBR,RFX3,EDN1,OPHN1,CORO1A,LRIG1,MICAL2,TLE4,CELF3,SYNGR3,SPRY4,MYLIP,MACF1,SNAP25,PLK4,HCRTR2" Transcription Factor Binding Site,V$CREB_Q2_01,V$CREB_Q2_01,TFBS,8.77E-08,8.60E-05,6.61E-06,4.94E-05,13,182,"PCSK1,CHGB,SLC25A25,SCG2,CHPF,HS3ST2,ZNF367,FOSB,NR4A2,EGR1,SYNGR3,SNAP25,PLK4" Transcription Factor Binding Site,V$ATF_B,V$ATF_B,TFBS,1.32E-07,1.30E-04,8.78E-06,6.56E-05,12,157,"ATP6V0C,CHGB,SST,SLC25A25,KCNF1,SCG2,HS3ST2,ZNF367,GPR3,FOSB,PDP1,SNAP25" Transcription Factor Binding Site,V$NRSF_01,V$NRSF_01,TFBS,1.34E-07,1.32E-04,8.78E-06,6.56E-05,9,77,"PCSK2,CHGA,SST,BDNF,PTPRN,HES1,CELF3,SNAP25,PHYHIPL" Transcription Factor Binding Site,TTGTTT_V$FOXO4_01,TTGTTT_V$FOXO4_01,TFBS,1.75E-07,1.71E-04,1.07E-05,7.99E-05,41,1599,"PCSK2,MSC,CLK4,ETS2,ETV5,SSBP2,ZNF385B,CHGA,NR4A1,SST,BDNF,CITED2,BRPF1,MCRS1,ARRDC3,AMIGO2,DYRK3,DYRK2,NPTX2,HTR1B,VWF,SYNM,FOSB,RBMS2,DUSP4,DUSP6,NR4A2,NR4A3,STMN1,PPAT,MIR137HG,RIT1,CORO1A,FSTL1,EGR1,EGR2,MAP4K5,KIAA0040,MPZL2,PATJ,HCRTR2" Transcription Factor Binding Site,TGTTTGY_V$HNF3_Q6,TGTTTGY_V$HNF3_Q6,TFBS,4.98E-07,4.88E-04,2.87E-05,2.14E-04,22,594,"A1BG,SOX4,PCSK2,PDYN,SERPINF1,ITPKB,CITED2,BBX,BRPF1,HTR1B,SRSF6,FOSB,DUSP6,NR4A3,PPAT,RFX3,FSTL1,EGR2,TLE4,SNAP25,MPZL2,HCRTR2" Transcription Factor Binding Site,V$ATF1_Q6,V$ATF1_Q6,TFBS,1.09E-06,1.07E-03,5.38E-05,4.02E-04,12,191,"PCSK1,ATP6V0C,CHGB,SST,SCG2,HS3ST2,CNN3,DYRK3,SRSF6,FOSB,PDP1,SNAP25" Transcription Factor Binding Site,AACTTT_UNKNOWN,AACTTT_UNKNOWN,TFBS,1.11E-06,1.09E-03,5.38E-05,4.02E-04,38,1529,"PCSK1,SOX4,SPRY2,PDYN,ETV5,U2AF2,SSBP2,BDNF,TMEFF2,ADM,BASP1,SCG2,TAC1,HES1,ARRDC3,AMIGO2,SEMA3F,CACNB1,NPTX2,SRSF6,PPP1R3B,FOSB,KAT6A,SHC1,NR4A2,NR4A3,RFX3,CRHBP,MIR137HG,RIT1,EGR2,TLE4,UTP4,CELF3,MYLIP,PRKAB2,TIMM50,HCRTR2" Transcription Factor Binding Site,V$STAT5A_04,V$STAT5A_04,TFBS,1.12E-06,1.10E-03,5.38E-05,4.02E-04,11,158,"SSBP2,ZNF385B,NR4A1,BDNF,CITED2,SCG2,ARC,ARRDC3,SRSF6,FSTL1,SPRY4" Transcription Factor Binding Site,V$SRF_Q4,V$SRF_Q4,TFBS,1.15E-06,1.13E-03,5.38E-05,4.02E-04,12,192,"MAPKAPK2,NR4A1,CITED2,FOSB,DUSP2,DUSP6,MUS81,EDN1,EGR1,EGR2,EGR4,RUNDC1" Transcription Factor Binding Site,V$NFY_01,V$NFY_01,TFBS,1.51E-06,1.48E-03,6.73E-05,5.02E-04,12,197,"ETV5,IER5,CKS2,SP140L,HES1,CNN3,NPTX2,DUSP6,STMN1,FADS1,PDP1,TLE4" Transcription Factor Binding Site,V$ATF3_Q6,V$ATF3_Q6,TFBS,1.96E-06,1.92E-03,8.36E-05,6.24E-04,12,202,"ATP6V0C,ZNF184,CHGB,SST,SCG2,CHPF,HS3ST2,CNN3,ZNF367,GPR3,FOSB,PDP1" Transcription Factor Binding Site,CGTSACG_V$PAX3_B,CGTSACG_V$PAX3_B,TFBS,3.07E-06,3.01E-03,1.21E-04,9.03E-04,9,111,"NAB2,CHGB,NR4A1,KCNE4,NR4A2,EGR1,EGR2,EGR4,PDP1" Transcription Factor Binding Site,V$SRF_Q6,V$SRF_Q6,TFBS,3.09E-06,3.03E-03,1.21E-04,9.03E-04,12,211,"MAPKAPK2,NR4A1,BDNF,CITED2,NAV1,FOSB,DUSP2,MUS81,EGR1,EGR2,PRKAB2,RUNDC1" Transcription Factor Binding Site,V$SRF_C,V$SRF_C,TFBS,4.23E-06,4.15E-03,1.59E-04,1.19E-03,11,181,"NR4A1,FHL2,FOSB,DUSP2,DUSP6,MUS81,EGR1,EGR2,EGR4,PRKAB2,RUNDC1" Transcription Factor Binding Site,YYCATTCAWW_UNKNOWN,YYCATTCAWW_UNKNOWN,TFBS,8.10E-06,7.94E-03,2.94E-04,2.20E-03,10,158,"ETS2,ETV5,BASP1,SCG2,GPR3,FOSB,DUSP4,NR4A3,CORO1A,SPRY4" Transcription Factor Binding Site,V$CREB_02,V$CREB_02,TFBS,1.04E-05,1.02E-02,3.57E-04,2.67E-03,11,199,"PCSK2,CHGB,MDN1,SCG2,GPR3,FOSB,NR4A2,NR4A3,PDP1,SNAP25,PLK4" Transcription Factor Binding Site,TGGAAA_V$NFAT_Q4_01,TGGAAA_V$NFAT_Q4_01,TFBS,1.06E-05,1.04E-02,3.57E-04,2.67E-03,35,1491,"SPRY2,NAB2,ETS2,ETV5,NCL,SSBP2,NR4A1,BDNF,C1QL1,CITED2,ADM,SCG2,HYAL3,TAC1,ARRDC3,SMURF2,PMP22,CACNB1,SRSF6,RBMS2,SHC1,NR4A2,LAMB3,NR4A3,STMN1,RGS2,OPHN1,MIR137HG,RIT1,FSTL1,EGR2,PDP1,CELF3,SNAP25,RUNDC1" Transcription Factor Binding Site,CCAWWNAAGG_V$SRF_Q4,CCAWWNAAGG_V$SRF_Q4,TFBS,1.42E-05,1.40E-02,4.65E-04,3.47E-03,7,74,"MAPKAPK2,NR4A1,FOSB,DUSP2,EGR1,EGR2,RUNDC1" Transcription Factor Binding Site,CTTTGT_V$LEF1_Q2,CTTTGT_V$LEF1_Q2,TFBS,2.17E-05,2.13E-02,6.86E-04,5.12E-03,35,1543,"PCSK1,PCSK2,SPRY2,CENPF,PDYN,ZNF184,BDNF,CITED2,LYVE1,KCNE4,BBX,BASP1,TAF1,ARRDC3,CHPF,CNN3,SEMA3F,DUSP4,KAT6A,NR4A2,APEX1,LAMB3,NR4A3,CCT2,STMN1,RFX3,TRIM3,OPHN1,MIR137HG,RIT1,MAP4K5,CELF3,RAB15,RBM24,HCRTR2" Transcription Factor Binding Site,V$CEBPDELTA_Q6,V$CEBPDELTA_Q6,TFBS,3.65E-05,3.58E-02,1.12E-03,8.36E-03,10,188,"PCSK2,SERPINF1,NR4A1,BDNF,CITED2,PTPRN,TAC1,ARRDC3,FOSB,NR4A2" Transcription Factor Binding Site,V$ELK1_01,V$ELK1_01,TFBS,5.20E-05,5.09E-02,1.54E-03,1.15E-02,10,196,"SOX4,U2AF2,DPP8,ITPKB,CITED2,PTPRN,RBMS2,SHC1,TLE4,HELZ2" Transcription Factor Binding Site,RTAAACA_V$FREAC2_01,RTAAACA_V$FREAC2_01,TFBS,5.65E-05,5.54E-02,1.57E-03,1.17E-02,21,745,"PCSK1,ATP6V0C,MSC,MATN2,ETV5,ZNF385B,ISG20,NR4A1,BDNF,CITED2,FHL2,SMURF2,SRSF6,DUSP4,KAT6A,NR4A2,EDN1,FSTL1,MAP4K5,SPRY4,SNAP25" Transcription Factor Binding Site,M30065,MIER1_TARGET_GENES,MSigDB,5.66E-05,5.55E-02,1.57E-03,1.17E-02,14,375,"PCSK1,HLA-E,SSBP2,CHGB,NR4A1,BDNF,SCG2,SYT5,HS3ST2,GPR19,TMEM179,UTP4,CELF3,MARF1" Transcription Factor Binding Site,V$CETS1P54_01,V$CETS1P54_01,TFBS,6.16E-05,6.04E-02,1.57E-03,1.17E-02,10,200,"SPRY2,MAPKAPK2,ZNF184,U2AF2,DPP8,PTPRN,SYT5,SRSF6,RBMS2,SHC1" Transcription Factor Binding Site,V$LFA1_Q6,V$LFA1_Q6,TFBS,6.16E-05,6.04E-02,1.57E-03,1.17E-02,10,200,"PDYN,NR4A1,ADM,BRPF1,MCRS1,HES1,GPR3,CACNB1,RHO,CELF3" Transcription Factor Binding Site,RYTTCCTG_V$ETS2_B,RYTTCCTG_V$ETS2_B,TFBS,6.20E-05,6.07E-02,1.57E-03,1.17E-02,23,866,"CNKSR1,MAPKAPK2,ETV5,BDNF,CITED2,PTPRN,SEMA3F,FLT3LG,RASA3,VPS39,RBMS2,DUSP4,SHC1,NR4A2,NR4A3,MIR137HG,CITED4,FSTL1,EGR1,MICAL2,MYLIP,HELZ2,KIAA0040" Transcription Factor Binding Site,CAGGTA_V$AREB6_01,CAGGTA_V$AREB6_01,TFBS,6.24E-05,6.11E-02,1.57E-03,1.17E-02,19,638,"SPRY2,ETV5,BDNF,ITPKB,BBX,BRPF1,KCNK1,STRN4,PXN,SYT5,CHPF,SMURF2,SEMA3F,CACNB1,CHSY1,LAMB3,MIR137HG,CORO1A,EGR2" Transcription Factor Binding Site,GGGAGGRR_V$MAZ_Q6,GGGAGGRR_V$MAZ_Q6,TFBS,6.85E-05,6.71E-02,1.68E-03,1.25E-02,38,1836,"SOX4,PCSK2,RNF112,NAB2,ETV5,IER5,SSBP2,BDNF,KCNE4,STRN4,ARC,TAC1,PLAT,HES1,TAF1,FAM181B,CHPF,COPS6,CNN3,GPR3,SRSF6,FOSB,DUSP4,DUSP6,SHC1,NR4A3,RFX3,LDLR,TRIM3,OPHN1,CORO1A,EGR1,EGR2,MICAL2,CELF3,SPRY4,SNAP25,HCRTR2" Transcription Factor Binding Site,GCTNWTTGK_UNKNOWN,GCTNWTTGK_UNKNOWN,TFBS,7.58E-05,7.43E-02,1.81E-03,1.35E-02,11,247,"SOX4,SPRY2,PDYN,ETV5,ZNF385B,CITED2,SP140L,SMURF2,CNN3,DYRK2,DUSP6" Transcription Factor Binding Site,M40816,ZNF740_TARGET_GENES,MSigDB,8.09E-05,7.93E-02,1.89E-03,1.41E-02,30,1317,"SPRY2,BRPF3,CLK4,U2AF2,MCCC2,NR4A1,DPP8,RNF43,ITPKB,CITED2,CEP170,BBX,METRN,STRN4,LBH,TAF1,C17orf80,FLT3LG,SUPT20H,ZNF329,KAT6A,STMN1,RGS4,TGIF1,CCND2-AS1,PDP1,MARF1,ELF2,ZNF664,BBC3" Transcription Factor Binding Site,M30251,ZFP91_TARGET_GENES,MSigDB,9.28E-05,9.09E-02,2.12E-03,1.58E-02,32,1458,"BRPF3,MAPKAPK2,TMEM198,SERPINF1,ETV5,IER5,ZFAND5,KCTD21,PFKP,INKA2,UBR5,TMEM160,DSTYK,NAV1,PLAT,HES1,ARRDC3,CHPF,MIEF2,PMP22,USP30,RBMS2,FAM131A,TXNDC12,SEC22C,LRIG1,MICAL2,TLE4,SPRY4,AACS,MACF1,BBC3" Transcription Factor Binding Site,V$PXR_Q2,V$PXR_Q2,TFBS,1.00E-04,9.80E-02,2.23E-03,1.66E-02,10,212,"ETV5,BDNF,PLAT,HES1,SRSF6,SHC1,NR4A3,FSTL1,EGR2,MACF1" Transcription Factor Binding Site,V$IRF7_01,V$IRF7_01,TFBS,1.04E-04,1.02E-01,2.26E-03,1.69E-02,10,213,"SOX4,SST,ARRDC3,TAP1,NR4A2,NR4A3,RFX3,SP110,MIR137HG,EGR4" Transcription Factor Binding Site,CAGNWMCNNNGAC_UNKNOWN,CAGNWMCNNNGAC_UNKNOWN,TFBS,1.12E-04,1.09E-01,2.37E-03,1.77E-02,6,71,"CHGA,CHGB,BDNF,PTPRN,CELF3,PHYHIPL" Transcription Factor Binding Site,V$SRF_01,V$SRF_01,TFBS,1.15E-04,1.12E-01,2.37E-03,1.77E-02,5,45,"FOSB,MUS81,EGR1,EGR2,EGR4" Transcription Factor Binding Site,RGAANNTTC_V$HSF1_01,RGAANNTTC_V$HSF1_01,TFBS,1.19E-04,1.17E-01,2.37E-03,1.77E-02,13,353,"BDNF,ADM,SLC35F3,SCG2,HES1,AMIGO2,SYNM,NR4A2,NR4A3,CCT2,RFX3,MIR137HG,ELF2" Transcription Factor Binding Site,V$TEF1_Q6,V$TEF1_Q6,TFBS,1.21E-04,1.18E-01,2.37E-03,1.77E-02,9,176,"MAPKAPK2,IER5,BDNF,CNN3,SHC1,LAMB3,OVGP1,EGR2,CELF3" Transcription Factor Binding Site,V$PAX4_01,V$PAX4_01,TFBS,1.21E-04,1.19E-01,2.37E-03,1.77E-02,10,217,"SPRY2,ETV5,STX1B,BDNF,C1QL1,HES1,DNM1,HS3ST2,NR4A3,TRIM3" Transcription Factor Binding Site,V$AP1_Q4_01,V$AP1_Q4_01,TFBS,1.31E-04,1.28E-01,2.51E-03,1.87E-02,10,219,"ETV5,ZNF385B,LYVE1,PTPRN,HS3ST2,RGS2,RIT1,FSTL1,MAP4K5,WDFY3" Transcription Factor Binding Site,M40802,ZSCAN29_TARGET_GENES,MSigDB,1.40E-04,1.37E-01,2.64E-03,1.97E-02,38,1901,"GP6,SAMD8,IER5,ZFAND5,SSBP2,NR4A1,B4GALT6,CITED2,TUBB6,CKS2,TRMT10C,BBX,DST,DSTYK,BRPF1,HES1,ARRDC3,DNM1,RNU2-2P,DUSP2,DUSP4,DUSP6,ZNF329,MUS81,ZNF736,LBR,TRIM3,TXNDC12,TGIF1,CNTD1,CITED4,FADS1,UTP4,RBM24,ZNF664,CEP57,PLK4,MX1" Transcription Factor Binding Site,TGCCAAR_V$NF1_Q6,TGCCAAR_V$NF1_Q6,TFBS,1.55E-04,1.52E-01,2.87E-03,2.14E-02,17,572,"SOX4,ATP6V0C,ETV5,PSMC5,BDNF,CITED2,RBMS2,DUSP2,DUSP4,EDN1,OPHN1,MIR137HG,RIT1,EGR2,MAP4K5,SPRY4,PHYHIPL" Transcription Factor Binding Site,CACGTG_V$MYC_Q2,CACGTG_V$MYC_Q2,TFBS,1.60E-04,1.57E-01,2.91E-03,2.17E-02,21,803,"U2AF2,NCL,BDNF,CITED2,KCNE4,MDN1,TAC1,ARRDC3,SEMA3F,PPP1R3B,DUSP4,KAT6A,APEX1,NR4A3,STMN1,PPAT,TRIM3,MICAL2,TLE4,UTP4,TIMM50" Transcription Factor Binding Site,V$E2F_Q3_01,V$E2F_Q3_01,TFBS,1.83E-04,1.80E-01,3.27E-03,2.44E-02,9,186,"PCSK1,MCM6,NCL,CHGB,CITED2,ZNF367,STMN1,TLE4,DNAJC5G" Transcription Factor Binding Site,V$STAT5A_02,V$STAT5A_02,TFBS,1.92E-04,1.88E-01,3.34E-03,2.49E-02,7,111,"PCSK2,ZNF184,BDNF,DYRK2,NR4A3,SP110,CITED4" Transcription Factor Binding Site,V$AP1_Q4,V$AP1_Q4,TFBS,1.94E-04,1.91E-01,3.34E-03,2.49E-02,10,230,"ETV5,ZNF385B,ISG20,LYVE1,PTPRN,DNM1,GPR3,LAMB3,EDN1,WDFY3" Transcription Factor Binding Site,TCCATTKW_UNKNOWN,TCCATTKW_UNKNOWN,TFBS,2.23E-04,2.19E-01,3.77E-03,2.82E-02,9,191,"SOX4,ETV5,NR4A1,NAV1,DUSP6,NR4A3,RFX3,MIR137HG,CELF3" Transcription Factor Binding Site,M30079,NAB2_TARGET_GENES,MSigDB,2.35E-04,2.30E-01,3.84E-03,2.87E-02,32,1535,"SPRY2,SAMD8,NAB2,MIF4GD,ETS2,SLC25A25,COX5A,STRADA,DSTYK,PXN,NKTR,SMURF2,MIR29B2CHG,DYRK3,SMG6,DYRK2,SEMA3F,PODXL,ZNF652,DUSP2,CHSY1,RFX3,TRIM3,TGIF1,SEC22C,EGR1,MAP4K5,PDP1,TLE4,MACF1,CEP57,BBC3" Transcription Factor Binding Site,M40710,HMGB1_TARGET_GENES,MSigDB,2.35E-04,2.30E-01,3.84E-03,2.87E-02,32,1535,"SPRY2,BRPF3,TBC1D2B,MIF4GD,NR4A1,PFKP,ITPKB,TUBB6,BBX,DTX4,PXN,DNM1,SMURF2,AMIGO2,PMP22,PLSCR4,SHROOM3,TMEM151B,APEX1,TRIM3,EVA1C,CORO1A,KLHL36,MAP4K5,UTP4,SYNGR3,KIAA0040,ELF2,RAB15,ZNF664,KCTD18,ANKRD33B" Transcription Factor Binding Site,V$SRF_Q5_01,V$SRF_Q5_01,TFBS,2.51E-04,2.46E-01,3.99E-03,2.98E-02,9,194,"MAPKAPK2,CITED2,FOSB,MUS81,TRIM3,EGR1,EGR2,PRKAB2,RUNDC1" Transcription Factor Binding Site,V$AHRARNT_01,V$AHRARNT_01,TFBS,2.52E-04,2.47E-01,3.99E-03,2.98E-02,7,116,"SOX4,NR4A1,BDNF,HES1,SHC1,PDP1,HELZ2" Transcription Factor Binding Site,V$BRN2_01,V$BRN2_01,TFBS,2.70E-04,2.65E-01,4.21E-03,3.14E-02,9,196,"ETV5,ZNF385B,CNN3,GPR3,DUSP6,NR4A3,RIT1,SPRY4,SNAP25" Transcription Factor Binding Site,CATTGTYY_V$SOX9_B1,CATTGTYY_V$SOX9_B1,TFBS,3.35E-04,3.28E-01,5.10E-03,3.81E-02,11,293,"PCSK2,BASP1,BRPF1,NAV1,CNN3,VWF,KAT6A,STMN1,EDN1,CORO1A,CELF3" Transcription Factor Binding Site,YTATTTTNR_V$MEF2_02,YTATTTTNR_V$MEF2_02,TFBS,3.38E-04,3.32E-01,5.10E-03,3.81E-02,16,555,"PCSK1,SOX4,NAB2,ZNF385B,NR4A1,BDNF,HES1,ARRDC3,MIEF2,FOSB,RFX3,EDN1,CITED4,MAP4K5,TLE4,SNAP25" Transcription Factor Binding Site,V$PAX2_02,V$PAX2_02,TFBS,3.90E-04,3.82E-01,5.79E-03,4.32E-02,9,206,"ZNF184,ETV5,BDNF,CITED2,BRPF1,PMP22,DUSP4,MIR137HG,FSTL1" Transcription Factor Binding Site,M40748,ISL1_TARGET_GENES,MSigDB,4.62E-04,4.53E-01,6.68E-03,4.99E-02,20,808,"SYNPO2,ZFAND5,CHGB,RNF43,EPM2AIP1,DST,STRADA,PLAT,FHL2,PLSCR4,PART1,RAF1,GPR19,DUSP6,SHC1,LBR,RFX3,ELF2,RPPH1,MYBL1" Transcription Factor Binding Site,V$SOX5_01,V$SOX5_01,TFBS,4.64E-04,4.54E-01,6.68E-03,4.99E-02,9,211,"PCSK2,ZNF385B,NR4A1,NPTX2,DUSP6,KAT6A,RFX3,MIR137HG,FSTL1" Transcription Factor Binding Site,GGGYGTGNY_UNKNOWN,GGGYGTGNY_UNKNOWN,TFBS,5.55E-04,5.44E-01,7.88E-03,5.88E-02,15,524,"NAB2,B4GALT6,BDNF,PXN,MIEF2,ZNF367,PMP22,FOSB,LAMB3,NR4A3,STMN1,MIR137HG,MAP4K5,CELF3,FUT1" Transcription Factor Binding Site,M30304,ZNF350_TARGET_GENES,MSigDB,6.07E-04,5.95E-01,8.45E-03,6.31E-02,30,1483,"ZNF136,CENPF,HLA-E,LGR4,ETV5,MCM6,TNFRSF10B,SLC25A25,TRMT10C,MDN1,BBX,TMEM160,BRPF1,TMEM231,ZNF160,RNU2-2P,MIEF2,USP30,ZNF680,DUSP6,SHC1,CHSY1,RGS4,TXNDC12,ARL4D,SEC22C,SPRY4,PRKAB2,ZNF799,CEP57" Transcription Factor Binding Site,V$ATF6_01,V$ATF6_01,TFBS,6.12E-04,6.00E-01,8.45E-03,6.31E-02,6,97,"NR4A1,GCC1,DUSP4,EGR1,EGR2,HCRTR2" Transcription Factor Binding Site,TGACCTY_V$ERR1_Q2,TGACCTY_V$ERR1_Q2,TFBS,6.65E-04,6.52E-01,9.05E-03,6.76E-02,20,832,"SOX4,PCSK2,ATP6V0C,CHGA,BDNF,KCNK1,DNM1,SEMA3F,NPTX2,HTR1B,SRSF6,STMN1,OPHN1,RHO,FSTL1,NACC2,MAP4K5,SYNGR3,SPRY4,WDFY3" Transcription Factor Binding Site,M40725,PCGF2_TARGET_GENES,MSigDB,7.07E-04,6.93E-01,9.49E-03,7.09E-02,21,899,"MSC,MATN2,ETV5,MIR181A1HG,PFKP,RNF43,TMEM178A,PXN,TAC1,NKTR,TMEM231,DNM1,FHL2,MIR29B2CHG,PART1,USP30,FEZF2,PODXL,RGS4,EDN1,SEC22C" Transcription Factor Binding Site,V$CREBP1_01,V$CREBP1_01,TFBS,7.19E-04,7.05E-01,9.52E-03,7.11E-02,7,138,"PCSK2,ETV5,ARRDC3,NPTX2,RBMS2,PDP1,SPRY4" Transcription Factor Binding Site,V$E2F1_Q4_01,V$E2F1_Q4_01,TFBS,7.56E-04,7.40E-01,9.87E-03,7.37E-02,8,181,"PCSK1,MCM6,NCL,CHGB,ZNF367,STMN1,TLE4,DNAJC5G" Transcription Factor Binding Site,V$AP1_Q2,V$AP1_Q2,TFBS,8.32E-04,8.16E-01,1.07E-02,7.99E-02,9,229,"ETV5,ZNF385B,LYVE1,PTPRN,DNM1,HS3ST2,LAMB3,MAP4K5,WDFY3" Transcription Factor Binding Site,V$E2F_Q6_01,V$E2F_Q6_01,TFBS,8.41E-04,8.24E-01,1.07E-02,7.99E-02,8,184,"MCM6,NCL,CITED2,ZNF367,DUSP6,STMN1,DNAJC5G,PLK4" Transcription Factor Binding Site,CTGCAGY_UNKNOWN,CTGCAGY_UNKNOWN,TFBS,8.68E-04,8.51E-01,1.08E-02,8.06E-02,16,606,"SOX4,SERPINF1,ETV5,CHGA,BDNF,CITED2,KCNE4,BBX,ARRDC3,DNM1,ZNF367,RGS2,TRIM3,EGR1,SPRY4,HELZ2" Transcription Factor Binding Site,V$OCT1_03,V$OCT1_03,TFBS,8.71E-04,8.53E-01,1.08E-02,8.06E-02,8,185,"ZNF385B,BDNF,CITED2,TMPRSS3,NPTX2,SRSF6,NR4A3,RIT1" Transcription Factor Binding Site,TGANTCA_V$AP1_C,TGANTCA_V$AP1_C,TFBS,9.20E-04,9.02E-01,1.13E-02,8.41E-02,21,918,"ETV5,ZNF385B,ISG20,BDNF,ADM,LYVE1,PTPRN,KCNK1,TAC1,HS3ST2,PMP22,GPR3,LAMB3,RGS2,RHO,RIT1,MAP4K5,MACF1,SNAP25,WDFY3,MPZL2" Transcription Factor Binding Site,V$ISRE_01,V$ISRE_01,TFBS,9.33E-04,9.15E-01,1.13E-02,8.43E-02,8,187,"ETV5,SSBP2,BDNF,KCNE4,BBX,ANAPC1,EGR2,CELF3" Transcription Factor Binding Site,M30335,ZNF512_TARGET_GENES,MSigDB,1.00E-03,9.83E-01,1.20E-02,8.95E-02,13,442,"MAPKAPK2,ZNF184,ETS2,U2AF2,TNFRSF10B,TMEM160,AMIGO2,SEMA3F,RBMS2,PLEKHA4,PRMT6,TLE4,CELF3" Transcription Factor Binding Site,V$AP1FJ_Q2,V$AP1FJ_Q2,TFBS,1.03E-03,1.00E+00,1.21E-02,9.01E-02,9,236,"ETV5,ZNF385B,ISG20,LYVE1,PTPRN,DNM1,HS3ST2,LAMB3,TLE4" Transcription Factor Binding Site,M40694,ZBTB24_TARGET_GENES,MSigDB,1.03E-03,1.00E+00,1.21E-02,9.01E-02,31,1604,"SYNPO2,TMEM198,MCCC2,KCTD21,PFKP,RNF43,INKA2,CEP170,SP140L,PTPRN,SCG2,KCNK1,SYT5,PLAT,CHPF,MIEF2,AMIGO2,GPR19,RBMS2,TENT5A,SHC1,NR4A2,MUS81,LAMB3,EDN1,TXNDC12,TGIF1,LRIG1,MAP4K5,PLK4,MX1" Transcription Factor Binding Site,M34471,POU2AF1_TARGET_GENES,MSigDB,1.11E-03,1.00E+00,1.27E-02,9.51E-02,21,932,"ACOX1,NAB2,ZNF184,ETV5,U2AF2,ZFAND5,SLC25A25,RNF43,CEP170,BRPF1,RNU2-2P,CNN3,USP30,SHROOM3,ZNF680,KAT6A,TGIF1,IFRD1,LRIG1,EGR2,RPPH1" Transcription Factor Binding Site,TGANNYRGCA_V$TCF11MAFG_01,TGANNYRGCA_V$TCF11MAFG_01,TFBS,1.12E-03,1.00E+00,1.27E-02,9.51E-02,9,239,"PSMC5,LYVE1,PTPRN,ARRDC3,CACNB1,DUSP2,NR4A3,RHO,WDFY3" Transcription Factor Binding Site,V$RFX1_01,V$RFX1_01,TFBS,1.14E-03,1.00E+00,1.27E-02,9.51E-02,8,193,"NAB2,ZNF385B,BDNF,CITED2,ADM,MIEF2,DUSP4,MIR137HG" Transcription Factor Binding Site,V$POU6F1_01,V$POU6F1_01,TFBS,1.14E-03,1.00E+00,1.27E-02,9.51E-02,8,193,"SOX4,ETV5,ZNF385B,SCG2,SYT5,GPR3,RFX3,FSTL1" Transcription Factor Binding Site,M30410,ZSCAN5C_TARGET_GENES,MSigDB,1.17E-03,1.00E+00,1.28E-02,9.53E-02,7,150,"SPRY2,BDNF,KCNK1,ARRDC3,DUSP6,RFX3,TGIF1" Transcription Factor Binding Site,V$AR_01,V$AR_01,TFBS,1.18E-03,1.00E+00,1.28E-02,9.53E-02,6,110,"ETV5,ITPKB,PMP22,RBMS2,SNAP25,RBM24" Transcription Factor Binding Site,GGGTGGRR_V$PAX4_03,GGGTGGRR_V$PAX4_03,TFBS,1.19E-03,1.00E+00,1.28E-02,9.53E-02,23,1068,"PCSK2,SPRY2,ATP6V0C,MSC,NAB2,ETV5,NR4A1,ITPKB,C1QL1,PTPRN,PXN,PLAT,ARRDC3,HS3ST2,PMP22,CACNB1,SRSF6,RBMS2,PLEKHA4,SHC1,NR4A3,CORO1A,SPRY4" Transcription Factor Binding Site,M40822,AUTS2_TARGET_GENES,MSigDB,1.25E-03,1.00E+00,1.33E-02,9.93E-02,13,453,"ACOX1,MIF4GD,PFKP,RNF43,CITED2,DST,DSTYK,KCNK1,MCRS1,ARRDC3,DUSP6,TLE4,RUNDC1" Transcription Factor Binding Site,V$HFH1_01,V$HFH1_01,TFBS,1.26E-03,1.00E+00,1.33E-02,9.93E-02,8,196,"ETV5,ISG20,NR4A1,CITED2,HTR1B,NR4A2,FSTL1,EGR2" Transcription Factor Binding Site,V$FOXO4_01,V$FOXO4_01,TFBS,1.30E-03,1.00E+00,1.36E-02,1.01E-01,8,197,"MSC,ETV5,ZNF385B,BDNF,CITED2,ARRDC3,SMURF2,FSTL1" Transcription Factor Binding Site,M40720,HMGB2_TARGET_GENES,MSigDB,1.43E-03,1.00E+00,1.48E-02,1.10E-01,12,404,"PCSK1,ISG20,TNFRSF10B,SMURF2,SMG6,PLSCR4,POT1,RGS4,TGIF1,IFRD1,SUDS3,CYP1B1-AS1" Transcription Factor Binding Site,M29932,CSHL1_TARGET_GENES,MSigDB,1.45E-03,1.00E+00,1.48E-02,1.11E-01,9,248,"ZFAND5,STRN4,HES1,RNU2-2P,APEX1,SP110,FADS1,SPRY4,RPPH1" Transcription Factor Binding Site,STTTCRNTTT_V$IRF_Q6,STTTCRNTTT_V$IRF_Q6,TFBS,1.52E-03,1.00E+00,1.54E-02,1.15E-01,7,157,"MSC,CHGB,CITED2,KCNE4,TAP1,FLT3LG,SRSF6" Transcription Factor Binding Site,V$DBP_Q6,V$DBP_Q6,TFBS,1.58E-03,1.00E+00,1.54E-02,1.15E-01,8,203,"SOX4,ZNF385B,ITPKB,DUSP6,NR4A3,RFX3,MAP4K5,TLE4" Transcription Factor Binding Site,YGTCCTTGR_UNKNOWN,YGTCCTTGR_UNKNOWN,TFBS,1.58E-03,1.00E+00,1.54E-02,1.15E-01,5,79,"CITED2,FHL2,GPI,NPTX2,PHYHIPL" Transcription Factor Binding Site,M30310,ZNF391_TARGET_GENES,MSigDB,1.59E-03,1.00E+00,1.54E-02,1.15E-01,21,960,"BRPF3,ETS2,NCL,SSBP2,KCTD21,DPP8,RNF43,CITED2,BBX,BRPF1,KCNK1,CNN3,USP30,FLT3LG,SRSF6,PPP1R3B,KAT6A,NR4A3,SEC22C,EGR2,SUDS3" Transcription Factor Binding Site,M40693,FOXP2_TARGET_GENES,MSigDB,1.60E-03,1.00E+00,1.54E-02,1.15E-01,35,1939,"ATP6V0C,TMEM198,NAB2,ETV5,ZFAND5,ISG20,TNFRSF10B,NR4A1,INKA2,TMEM178A,STRN4,ARHGAP29,SYT5,C3orf80,LINC00632,ARRDC3,MED17,ZNF160,PMP22,GPR3,USP30,DUSP4,KAT6A,NR4A2,STMN1,PPAT,TXNDC12,PRMT6,TGIF1,EGR4,MAP4K5,SERPINB1,MACF1,ELF2,PHYHIPL" Transcription Factor Binding Site,M40786,KDM7A_TARGET_GENES,MSigDB,1.60E-03,1.00E+00,1.54E-02,1.15E-01,34,1866,"SPRY2,ZNF184,NCL,SSBP2,DPP8,BDNF,INKA2,CEP170,DST,BRPF1,STRN4,ARRDC3,DNM1,C17orf80,FOXF1,DYRK2,SEMA3F,HTR1B,SUPT20H,KAT6A,MUS81,LBR,RGS2,MIR137HG,EVA1C,IFRD1,FSTL1,NACC2,CCND2-AS1,TLE4,UTP4,MACF1,PATJ,BBC3" Transcription Factor Binding Site,V$E47_01,V$E47_01,TFBS,1.63E-03,1.00E+00,1.55E-02,1.15E-01,8,204,"CITED2,PODXL,NR4A3,CORO1A,CELF3,MYLIP,MACF1,PLK4" Transcription Factor Binding Site,V$HNF3_Q6,V$HNF3_Q6,TFBS,1.70E-03,1.00E+00,1.60E-02,1.20E-01,7,160,"NR4A1,ITPKB,FOSB,DUSP6,NR4A3,EGR2,SNAP25" Transcription Factor Binding Site,V$SREBP1_Q6,V$SREBP1_Q6,TFBS,1.73E-03,1.00E+00,1.61E-02,1.20E-01,8,206,"ATP6V0C,RNF112,ETV5,SSBP2,CACNB1,LDLR,CORO1A,MACF1" Transcription Factor Binding Site,V$FREAC4_01,V$FREAC4_01,TFBS,1.77E-03,1.00E+00,1.64E-02,1.22E-01,6,119,"MSC,IER5,ZNF385B,NR4A1,CITED2,SPRY4" Transcription Factor Binding Site,M30300,ZNF329_TARGET_GENES,MSigDB,1.81E-03,1.00E+00,1.64E-02,1.23E-01,15,590,"ZNF136,SYNPO2,ACOX1,PFKP,B4GALT6,MDN1,DST,DSTYK,HES1,USP30,TNIP2,DUSP6,LDLR,NACC2,MT-ND1" Transcription Factor Binding Site,M30352,ZNF563_TARGET_GENES,MSigDB,1.81E-03,1.00E+00,1.64E-02,1.23E-01,16,651,"BRPF3,ISG20,NR4A1,STX1B,B4GALT6,CITED2,METRN,KCNK1,PXN,DCLK2,CNN3,C17orf80,PMP22,GPI,FEZF2,ZNF329" Transcription Factor Binding Site,GATTGGY_V$NFY_Q6_01,GATTGGY_V$NFY_Q6_01,TFBS,1.87E-03,1.00E+00,1.68E-02,1.25E-01,20,907,"SOX4,CENPF,ETV5,IER5,ZNF385B,BDNF,EPM2AIP1,CKS2,ARRDC3,CNN3,NPTX2,SRSF6,FOSB,SHC1,STMN1,RGS4,FADS1,PDP1,TLE4,CYP1B1-AS1" Transcription Factor Binding Site,V$CEBPB_02,V$CEBPB_02,TFBS,1.89E-03,1.00E+00,1.68E-02,1.25E-01,8,209,"SERPINF1,BDNF,C1QL1,TAC1,ARRDC3,DYRK3,CITED4,SPRY4" Transcription Factor Binding Site,M30161,SKIL_TARGET_GENES,MSigDB,1.93E-03,1.00E+00,1.68E-02,1.25E-01,35,1961,"ATP6V0C,FAM168B,CENPF,ANKRD37,TMEM198,NAB2,ISG20,TNFRSF10B,SLC25A25,COX5A,TMEM160,BRPF1,ARRDC3,DNM1,CHPF,TAP1,SMURF2,MIR29B2CHG,DYRK3,SMG6,FLT3LG,TNIP2,NTMT1,CHSY1,CORO1A,LRIG1,EGR2,MAP4K5,PDP1,CELF3,PRKAB2,SERPINB1,ZNF664,KCTD18,BBC3" Transcription Factor Binding Site,V$NFY_Q6_01,V$NFY_Q6_01,TFBS,1.95E-03,1.00E+00,1.68E-02,1.25E-01,8,210,"SPRY2,ETV5,CNN3,FOSB,STMN1,FADS1,MICAL2,PDP1" Transcription Factor Binding Site,V$FOXD3_01,V$FOXD3_01,TFBS,1.95E-03,1.00E+00,1.68E-02,1.25E-01,7,164,"ETV5,NR4A1,CITED2,GPR3,FSTL1,EGR2,TLE4" Transcription Factor Binding Site,TAATTA_V$CHX10_01,TAATTA_V$CHX10_01,TFBS,1.96E-03,1.00E+00,1.68E-02,1.25E-01,16,656,"PCSK2,ETS2,U2AF2,ZNF385B,BDNF,CITED2,BASP1,ARC,TAC1,SMURF2,CNN3,PART1,VWF,RFX3,MIR137HG,TLE4" Transcription Factor Binding Site,M34461,AHRR_TARGET_GENES,MSigDB,1.99E-03,1.00E+00,1.70E-02,1.27E-01,27,1388,"WDR33,ACOX1,LGR4,SSBP2,RNF43,EPM2AIP1,TRMT10C,UBR5,DSTYK,DTX4,HES1,ARRDC3,DNM1,GPR19,RASA3,ZNF652,TENT5A,NR4A2,CHSY1,PRMT6,TGIF1,IFRD1,PDP1,MT-ND1,PRKAB2,ELF2,MYBL1" Transcription Factor Binding Site,V$NFY_Q6,V$NFY_Q6,TFBS,2.01E-03,1.00E+00,1.70E-02,1.27E-01,8,211,"SPRY2,CENPF,EPM2AIP1,CKS2,ARRDC3,SRSF6,TLE4,CYP1B1-AS1" Transcription Factor Binding Site,M40709,HBZ_TARGET_GENES,MSigDB,2.03E-03,1.00E+00,1.70E-02,1.27E-01,18,784,"MCCC2,DPP8,RNF43,DST,DTX4,STRN4,RNU2-2P,SMG6,TNIP2,CHSY1,STMN1,SP110,EGR2,PDP1,CD59,MACF1,CYP1B1-AS1,BBC3" Transcription Factor Binding Site,V$FREAC2_01,V$FREAC2_01,TFBS,2.07E-03,1.00E+00,1.72E-02,1.28E-01,8,212,"PCSK1,ETV5,ZNF385B,BDNF,CITED2,SYT1,DUSP4,MAP4K5" Transcription Factor Binding Site,M30155,SFMBT1_TARGET_GENES,MSigDB,2.13E-03,1.00E+00,1.75E-02,1.31E-01,31,1680,"SPRY2,ETV5,ZFAND5,SSBP2,ISG20,DPP8,CEP170,ADM,LYVE1,DST,COX5A,BRPF1,DNM1,ZNF160,TAP1,ZNF367,RAF1,SYNM,DUSP6,NTMT1,NR4A2,MUS81,CHSY1,RGS2,OPHN1,EGR1,MAP4K5,PRKAB2,NIPAL1,MACF1,ELF2" Transcription Factor Binding Site,V$AP1_Q6,V$AP1_Q6,TFBS,2.32E-03,1.00E+00,1.89E-02,1.41E-01,8,216,"ETV5,ZNF385B,LYVE1,PTPRN,HS3ST2,GPR3,RIT1,WDFY3" Transcription Factor Binding Site,TTCYNRGAA_V$STAT5B_01,TTCYNRGAA_V$STAT5B_01,TFBS,2.34E-03,1.00E+00,1.89E-02,1.41E-01,9,266,"A1BG,PCSK2,ETV5,BDNF,FLT3LG,TNIP2,DUSP4,NR4A3,CITED4" Transcription Factor Binding Site,V$TST1_01,V$TST1_01,TFBS,2.39E-03,1.00E+00,1.92E-02,1.43E-01,8,217,"ZNF385B,CITED2,ARRDC3,NR4A2,NR4A3,RFX3,EGR2,CELF3" Transcription Factor Binding Site,V$MYCMAX_B,V$MYCMAX_B,TFBS,2.46E-03,1.00E+00,1.96E-02,1.46E-01,8,218,"SOX4,SERPINF1,NCL,ZNF367,STMN1,MICAL2,SNAP25,RBM24" Transcription Factor Binding Site,WTGAAAT_UNKNOWN,WTGAAAT_UNKNOWN,TFBS,2.62E-03,1.00E+00,2.06E-02,1.54E-01,13,493,"PCSK2,ZNF385B,GPR3,NPTX2,DUSP6,KAT6A,NR4A3,STMN1,RFX3,SP110,MIR137HG,RIT1,PRKAB2" Transcription Factor Binding Site,V$HFH8_01,V$HFH8_01,TFBS,2.64E-03,1.00E+00,2.06E-02,1.54E-01,7,173,"ETV5,NR4A1,ITPKB,FHL2,NR4A2,FSTL1,EGR2" Transcription Factor Binding Site,TATAAA_V$TATA_01,TATAAA_V$TATA_01,TFBS,2.67E-03,1.00E+00,2.06E-02,1.54E-01,22,1070,"MSC,ETV5,ZNF385B,NR4A1,BDNF,CITED2,TMPRSS3,ARRDC3,FHL2,DYRK2,PART1,SRSF6,NR4A3,RGS4,EDN1,OPHN1,RHO,RIT1,EGR2,TLE4,CELF3,SNAP25" Transcription Factor Binding Site,V$EFC_Q6,V$EFC_Q6,TFBS,2.67E-03,1.00E+00,2.06E-02,1.54E-01,8,221,"ETS2,BDNF,CITED2,STRN4,HES1,MIEF2,FOSB,HELZ2" Transcription Factor Binding Site,M29902,BARX1_TARGET_GENES,MSigDB,2.73E-03,1.00E+00,2.09E-02,1.56E-01,25,1279,"CENPF,ZNF184,HLA-E,IER5,NCL,KCTD21,INKA2,ADM,CKS2,TMEM160,BRPF1,MED17,MIEF2,PLSCR4,USP30,GPR19,VPS39,RBMS2,SHC1,LBR,LDLR,TXNDC12,FADS1,SPRY4,TIMM50" Transcription Factor Binding Site,M40843,UBP1_TARGET_GENES,MSigDB,2.79E-03,1.00E+00,2.12E-02,1.58E-01,34,1931,"SPRY2,CNKSR1,NAB2,ETS2,PSMC5,U2AF2,KCTD21,CHGB,TNFRSF10B,DPP8,ADM,MDN1,BBX,PTPRN,UBR5,MCRS1,TAP1,DYRK3,PLSCR4,RAF1,MUS81,CCT2,STMN1,TXNDC12,CITED4,FADS1,SUDS3,MAP4K5,UTP4,MYLIP,NIPAL1,MPZL2,PATJ,RPPH1" Transcription Factor Binding Site,V$NF1_Q6,V$NF1_Q6,TFBS,2.82E-03,1.00E+00,2.13E-02,1.59E-01,8,223,"SOX4,SSBP2,CHGA,BDNF,CITED2,CACNB1,LAMB3,CITED4" Transcription Factor Binding Site,M40775,ZNF318_TARGET_GENES,MSigDB,2.86E-03,1.00E+00,2.14E-02,1.60E-01,13,498,"ISG20,SP140L,HES1,RNU2-2P,TAP1,GPI,FLT3LG,FOSB,PLEKHA4,MUS81,NR4A3,SP110,TGIF1" Transcription Factor Binding Site,V$NFKB_C,V$NFKB_C,TFBS,2.90E-03,1.00E+00,2.14E-02,1.60E-01,8,224,"PCSK2,MSC,IER5,BDNF,C1QL1,LAMB3,EGR2,SNAP25" Transcription Factor Binding Site,M40703,PHF2_TARGET_GENES,MSigDB,2.91E-03,1.00E+00,2.14E-02,1.60E-01,28,1498,"ACOX1,PSMC5,ZFAND5,NCL,KCTD21,CITED2,ADM,DST,HYAL3,BRPF1,CIAPIN1,TSPO,MED17,TAP1,SMURF2,C17orf80,DYRK3,PLSCR4,DUSP6,NTMT1,PLEKHA4,NR4A2,CCT2,KLHL36,PDP1,NIPAL1,ZNF664,ANKRD33B" Transcription Factor Binding Site,V$FXR_IR1_Q6,V$FXR_IR1_Q6,TFBS,2.93E-03,1.00E+00,2.14E-02,1.60E-01,5,91,"CITED2,HES1,NPTX2,OVGP1,MACF1" Transcription Factor Binding Site,MGGAAGTG_V$GABP_B,MGGAAGTG_V$GABP_B,TFBS,2.95E-03,1.00E+00,2.14E-02,1.60E-01,14,560,"SPRY2,ZNF184,ETV5,U2AF2,DPP8,BDNF,CITED2,CHPF,NPTX2,RBMS2,SHC1,NR4A2,EGR2,PATJ" Transcription Factor Binding Site,V$E2F_Q3,V$E2F_Q3,TFBS,3.00E-03,1.00E+00,2.16E-02,1.61E-01,7,177,"PCSK1,MCM6,NCL,ZNF367,STMN1,DNAJC5G,PLK4" Transcription Factor Binding Site,YNTTTNNNANGCARM_UNKNOWN,YNTTTNNNANGCARM_UNKNOWN,TFBS,3.21E-03,1.00E+00,2.30E-02,1.71E-01,4,57,"ETV5,ZNF385B,CNN3,HCRTR2" Transcription Factor Binding Site,WGTTNNNNNAAA_UNKNOWN,WGTTNNNNNAAA_UNKNOWN,TFBS,3.34E-03,1.00E+00,2.37E-02,1.77E-01,12,448,"PCSK1,ETS2,ETV5,SSBP2,BDNF,BASP1,SRSF6,DUSP6,NR4A2,NR4A3,RFX3,RIT1" Transcription Factor Binding Site,TTANTCA_UNKNOWN,TTANTCA_UNKNOWN,TFBS,3.39E-03,1.00E+00,2.39E-02,1.79E-01,17,758,"PCSK1,SOX4,MAPKAPK2,ETS2,TMEFF2,CITED2,TAC1,PLAT,DNM1,PMP22,PART1,NPTX2,RBMS2,DUSP6,CRHBP,EDN1,PDP1" Transcription Factor Binding Site,SMTTTTGT_UNKNOWN,SMTTTTGT_UNKNOWN,TFBS,3.44E-03,1.00E+00,2.41E-02,1.80E-01,10,336,"MAPKAPK2,CLK4,ETS2,CITED2,CNN3,DUSP4,DUSP6,NR4A2,NR4A3,STMN1" Transcription Factor Binding Site,M40770,ATXN7L3_TARGET_GENES,MSigDB,3.52E-03,1.00E+00,2.43E-02,1.82E-01,9,283,"TMEM198,IER5,ZFAND5,RNF43,CITED2,HES1,CHPF,SHROOM3,NR4A2" Transcription Factor Binding Site,V$E2F1DP1_01,V$E2F1DP1_01,TFBS,3.60E-03,1.00E+00,2.43E-02,1.82E-01,7,183,"PCSK1,MCM6,NCL,BRPF1,ZNF367,STMN1,DNAJC5G" Transcription Factor Binding Site,V$E2F4DP2_01,V$E2F4DP2_01,TFBS,3.60E-03,1.00E+00,2.43E-02,1.82E-01,7,183,"PCSK1,MCM6,NCL,BRPF1,ZNF367,STMN1,DNAJC5G" Transcription Factor Binding Site,V$E2F1DP2_01,V$E2F1DP2_01,TFBS,3.60E-03,1.00E+00,2.43E-02,1.82E-01,7,183,"PCSK1,MCM6,NCL,BRPF1,ZNF367,STMN1,DNAJC5G" Transcription Factor Binding Site,V$E2F_02,V$E2F_02,TFBS,3.60E-03,1.00E+00,2.43E-02,1.82E-01,7,183,"PCSK1,MCM6,NCL,BRPF1,ZNF367,STMN1,DNAJC5G" Transcription Factor Binding Site,MYAATNNNNNNNGGC_UNKNOWN,MYAATNNNNNNNGGC_UNKNOWN,TFBS,3.69E-03,1.00E+00,2.48E-02,1.85E-01,5,96,"CENPF,ETV5,BDNF,SRSF6,TLE4" Transcription Factor Binding Site,GTGGGTGK_UNKNOWN,GTGGGTGK_UNKNOWN,TFBS,3.78E-03,1.00E+00,2.51E-02,1.87E-01,8,234,"PCSK2,BASP1,GPR3,HTR1B,NR4A3,FSTL1,EGR1,RUNDC1" Transcription Factor Binding Site,V$E2F_Q4_01,V$E2F_Q4_01,TFBS,3.82E-03,1.00E+00,2.51E-02,1.87E-01,7,185,"MCM6,NCL,CITED2,ZNF367,STMN1,DNAJC5G,PLK4" Transcription Factor Binding Site,V$NKX3A_01,V$NKX3A_01,TFBS,3.82E-03,1.00E+00,2.51E-02,1.87E-01,7,185,"PCSK2,NR4A1,SLC25A25,PART1,SRSF6,MIR137HG,EGR2" Transcription Factor Binding Site,V$COMP1_01,V$COMP1_01,TFBS,3.86E-03,1.00E+00,2.51E-02,1.87E-01,5,97,"SRSF6,NR4A3,MIR137HG,TLE4,SPRY4" Transcription Factor Binding Site,M30398,ZNF843_TARGET_GENES,MSigDB,3.86E-03,1.00E+00,2.51E-02,1.87E-01,19,900,"ETV5,SSBP2,KCTD21,DPP8,RNF43,BBX,DST,COX5A,BRPF1,KCNK1,PXN,MS4A8,USP30,DUSP6,NTMT1,SUDS3,TLE4,UTP4,WDFY3" Transcription Factor Binding Site,V$NFKB_Q6_01,V$NFKB_Q6_01,TFBS,4.05E-03,1.00E+00,2.58E-02,1.93E-01,7,187,"PCSK2,MSC,IER5,BDNF,C1QL1,DUSP6,SNAP25" Transcription Factor Binding Site,V$TCF11_01,V$TCF11_01,TFBS,4.05E-03,1.00E+00,2.58E-02,1.93E-01,7,187,"PCSK2,BDNF,FHL2,HS3ST2,SRSF6,NR4A3,RIT1" Transcription Factor Binding Site,M29964,FEV_TARGET_GENES,MSigDB,4.07E-03,1.00E+00,2.58E-02,1.93E-01,30,1681,"WDR33,TMEM198,EPM2AIP1,MDN1,COX5A,BRPF1,NAV1,GCC1,CHPF,MIEF2,C17orf80,ZNF367,RAF1,GPR3,FLT3LG,VPS39,PPP1R3B,RBMS2,TENT5A,MUS81,PPAT,SP110,LDLR,EDN1,ARL4D,SPRY4,MARF1,NIPAL1,MPZL2,CEP57" Transcription Factor Binding Site,V$AP1_C,V$AP1_C,TFBS,4.08E-03,1.00E+00,2.58E-02,1.93E-01,8,237,"ETV5,ZNF385B,LYVE1,HS3ST2,RGS2,RIT1,FSTL1,WDFY3" Transcription Factor Binding Site,V$MYB_Q3,V$MYB_Q3,TFBS,4.17E-03,1.00E+00,2.62E-02,1.96E-01,7,188,"SSBP2,CHGA,BDNF,ZNF367,RASA3,RFX3,RGS2" Transcription Factor Binding Site,V$E2F1_Q3,V$E2F1_Q3,TFBS,4.42E-03,1.00E+00,2.76E-02,2.06E-01,7,190,"PCSK1,MCM6,NCL,ZNF367,STMN1,DNAJC5G,PLK4" Transcription Factor Binding Site,M30353,ZNF577_TARGET_GENES,MSigDB,4.52E-03,1.00E+00,2.80E-02,2.09E-01,13,526,"CLK4,TNFRSF10B,NR4A1,INKA2,USP30,VPS39,EVA1C,MAP4K5,UTP4,AACS,SNAP25,CYP1B1-AS1,RPPH1" Transcription Factor Binding Site,V$SOX9_B1,V$SOX9_B1,TFBS,4.68E-03,1.00E+00,2.88E-02,2.15E-01,7,192,"SOX4,NR4A1,BASP1,NAV1,DUSP6,KAT6A,CELF3" Transcription Factor Binding Site,M40742,GTF2A2_TARGET_GENES,MSigDB,4.73E-03,1.00E+00,2.90E-02,2.17E-01,13,529,"BRPF3,HLA-E,IER5,SSBP2,LBH,HES1,RNU2-2P,SRSF6,FOSB,RGS2,IFRD1,EGR1,MYLIP" Transcription Factor Binding Site,TGCGCANK_UNKNOWN,TGCGCANK_UNKNOWN,TFBS,4.81E-03,1.00E+00,2.91E-02,2.17E-01,11,410,"PCSK2,U2AF2,BDNF,CKS2,STRADA,MCRS1,ARRDC3,DNM1,FOSB,SPRY4,RBM24" Transcription Factor Binding Site,V$PIT1_Q6,V$PIT1_Q6,TFBS,4.81E-03,1.00E+00,2.91E-02,2.17E-01,7,193,"SOX4,ETV5,ZNF385B,BDNF,CITED2,DUSP6,MIR137HG" Transcription Factor Binding Site,V$ARNT_02,V$ARNT_02,TFBS,4.94E-03,1.00E+00,2.95E-02,2.21E-01,7,194,"U2AF2,NCL,BDNF,KCNE4,APEX1,STMN1,TRIM3" Transcription Factor Binding Site,V$MYOD_Q6_01,V$MYOD_Q6_01,TFBS,4.94E-03,1.00E+00,2.95E-02,2.21E-01,7,194,"NR4A1,BDNF,SCG2,ARRDC3,SEMA3F,STMN1,EGR2" Transcription Factor Binding Site,V$NKX22_01,V$NKX22_01,TFBS,5.04E-03,1.00E+00,2.99E-02,2.23E-01,6,147,"PDYN,ETV5,SRSF6,MIR137HG,CITED4,EGR2" Transcription Factor Binding Site,CATRRAGC_UNKNOWN,CATRRAGC_UNKNOWN,TFBS,5.19E-03,1.00E+00,3.04E-02,2.27E-01,5,104,"CHGA,DPP8,HTR1B,SRSF6,MAP4K5" Transcription Factor Binding Site,M30157,SIPA1_TARGET_GENES,MSigDB,5.21E-03,1.00E+00,3.04E-02,2.27E-01,6,148,"ANKRD37,HLA-E,DST,TNIP2,MT-ND1,RPPH1" Transcription Factor Binding Site,V$MSX1_01,V$MSX1_01,TFBS,5.21E-03,1.00E+00,3.04E-02,2.27E-01,6,148,"SOX4,SPRY2,ETV5,BDNF,PMP22,UTP4" Transcription Factor Binding Site,CTTTAAR_UNKNOWN,CTTTAAR_UNKNOWN,TFBS,5.42E-03,1.00E+00,3.14E-02,2.35E-01,17,795,"PDYN,SERPINF1,ETV5,IER5,BDNF,BRPF1,ARRDC3,COPS6,MIEF2,ZNF367,PMP22,KAT6A,EDN1,OPHN1,MIR137HG,RAB15,RBM24" Transcription Factor Binding Site,M30149,RYBP_TARGET_GENES,MSigDB,5.58E-03,1.00E+00,3.22E-02,2.40E-01,32,1869,"PCSK1,MSC,NAB2,MIF4GD,NR4A1,PFKP,BDNF,CITED2,CEP170,BASP1,KCNF1,DSTYK,BRPF1,TSPO,PXN,NAV1,HES1,GCC1,HS3ST2,TAP1,AMIGO2,USP30,FEZF2,PPP1R3B,DUSP6,NR4A2,CCND2-AS1,SUDS3,SPRY4,AACS,PHYHIPL,RPPH1" Transcription Factor Binding Site,V$FREAC3_01,V$FREAC3_01,TFBS,5.67E-03,1.00E+00,3.25E-02,2.42E-01,7,199,"PCSK1,CITED2,SCG2,LAMB3,FSTL1,EGR2,MAP4K5" Transcription Factor Binding Site,V$HSF_Q6,V$HSF_Q6,TFBS,5.73E-03,1.00E+00,3.27E-02,2.44E-01,6,151,"PCSK1,LYVE1,SHC1,EDN1,CORO1A,SNAP25" Transcription Factor Binding Site,V$SMAD4_Q6,V$SMAD4_Q6,TFBS,5.82E-03,1.00E+00,3.28E-02,2.45E-01,7,200,"NAB2,PSMC5,SST,MCRS1,SRSF6,TRIM3,PDP1" Transcription Factor Binding Site,V$WHN_B,V$WHN_B,TFBS,5.82E-03,1.00E+00,3.28E-02,2.45E-01,7,200,"SPRY2,BDNF,TAC1,PMP22,NR4A3,OPHN1,RBM24" Transcription Factor Binding Site,M30125,PRDM12_TARGET_GENES,MSigDB,5.92E-03,1.00E+00,3.31E-02,2.47E-01,6,152,"TNFRSF10B,VPS39,MAP4K5,UTP4,SNAP25,CYP1B1-AS1" Transcription Factor Binding Site,M30192,TAZ_TARGET_GENES,MSigDB,6.01E-03,1.00E+00,3.35E-02,2.50E-01,12,483,"ISG20,NR4A1,DST,CNN3,GPI,GPR3,FLT3LG,SHROOM3,STMN1,EDN1,CORO1A,BBC3" Transcription Factor Binding Site,V$TBP_01,V$TBP_01,TFBS,6.30E-03,1.00E+00,3.47E-02,2.59E-01,7,203,"MSC,NR4A1,FHL2,DYRK2,RIT1,EGR2,CELF3" Transcription Factor Binding Site,V$IRF1_01,V$IRF1_01,TFBS,6.30E-03,1.00E+00,3.47E-02,2.59E-01,7,203,"ITPKB,KCNE4,BBX,TAP1,FLT3LG,RIT1,EGR2" Transcription Factor Binding Site,CGGAARNGGCNG_UNKNOWN,CGGAARNGGCNG_UNKNOWN,TFBS,6.60E-03,1.00E+00,3.54E-02,2.64E-01,3,36,"VPS39,DUSP6,EGR1" Transcription Factor Binding Site,V$AP4_01,V$AP4_01,TFBS,6.64E-03,1.00E+00,3.54E-02,2.64E-01,7,205,"PCSK1,NAB2,SSBP2,FLT3LG,NR4A2,SPRY4,SNAP25" Transcription Factor Binding Site,V$ALPHACP1_01,V$ALPHACP1_01,TFBS,6.64E-03,1.00E+00,3.54E-02,2.64E-01,7,205,"SPRY2,SLC25A25,CKS2,SP140L,HES1,MIEF2,DUSP6" Transcription Factor Binding Site,V$MYB_Q5_01,V$MYB_Q5_01,TFBS,6.64E-03,1.00E+00,3.54E-02,2.64E-01,7,205,"SSBP2,BDNF,RASA3,SYNM,KAT6A,RFX3,RGS2" Transcription Factor Binding Site,V$TEF_Q6,V$TEF_Q6,TFBS,6.64E-03,1.00E+00,3.54E-02,2.64E-01,7,205,"SOX4,SPRY2,ETV5,ARRDC3,NPTX2,EGR2,TLE4" Transcription Factor Binding Site,M30299,ZNF322_TARGET_GENES,MSigDB,6.65E-03,1.00E+00,3.54E-02,2.64E-01,19,948,"IER5,ISG20,STX1B,CEP170,MDN1,DST,STRADA,HYAL3,ARRDC3,MED17,FHL2,GPI,PODXL,MUS81,LDLR,RIT1,CNTD1,SEC22C,MYBL1" Transcription Factor Binding Site,V$TAL1BETAITF2_01,V$TAL1BETAITF2_01,TFBS,6.81E-03,1.00E+00,3.61E-02,2.69E-01,7,206,"BRPF1,STRN4,TAC1,FOSB,TRIM3,MIR137HG,MACF1" Transcription Factor Binding Site,M30176,SOX3_TARGET_GENES,MSigDB,6.88E-03,1.00E+00,3.63E-02,2.71E-01,13,554,"ZFAND5,SLC25A25,NKTR,ARRDC3,TMEM231,CNN3,GPR19,CCT2,STMN1,PDP1,TLE4,CELF3,SPRY4" Transcription Factor Binding Site,V$IPF1_Q4,V$IPF1_Q4,TFBS,7.16E-03,1.00E+00,3.75E-02,2.80E-01,7,208,"SOX4,BDNF,SMURF2,POT1,NR4A2,EGR2,TLE4" Transcription Factor Binding Site,M30237,ZBTB12_TARGET_GENES,MSigDB,7.31E-03,1.00E+00,3.81E-02,2.84E-01,24,1311,"SAMD8,CLK4,SLC25A25,RNF43,B4GALT6,INKA2,CEP170,DST,HYAL3,BRPF1,ARRDC3,MIEF2,VPS39,FOSB,DUSP6,ZNF736,EVA1C,TGIF1,EGR1,MACF1,CEP57,RUNDC1,PLK4,MYBL1" Transcription Factor Binding Site,AAAYWAACM_V$HFH4_01,AAAYWAACM_V$HFH4_01,TFBS,7.35E-03,1.00E+00,3.81E-02,2.84E-01,7,209,"BDNF,HTR1B,FOSB,NR4A3,FSTL1,EGR2,MYLIP" Transcription Factor Binding Site,V$AMEF2_Q6,V$AMEF2_Q6,TFBS,7.72E-03,1.00E+00,3.98E-02,2.97E-01,7,211,"ZNF385B,NR4A1,BDNF,DYRK2,RFX3,CRHBP,EDN1" Transcription Factor Binding Site,V$STAT_01,V$STAT_01,TFBS,7.91E-03,1.00E+00,4.06E-02,3.03E-01,7,212,"ETV5,BDNF,SRSF6,TNIP2,DUSP4,NR4A3,CITED4" Transcription Factor Binding Site,V$TFIIA_Q6,V$TFIIA_Q6,TFBS,8.11E-03,1.00E+00,4.14E-02,3.09E-01,7,213,"IER5,NR4A1,FHL2,SMURF2,GPR19,FOSB,EGR1" Transcription Factor Binding Site,TGASTMAGC_V$NFE2_01,TGASTMAGC_V$NFE2_01,TFBS,8.23E-03,1.00E+00,4.18E-02,3.12E-01,6,163,"ETV5,LYVE1,PTPRN,HS3ST2,RIT1,WDFY3" Transcription Factor Binding Site,M40820,ZNF555_TARGET_GENES,MSigDB,8.51E-03,1.00E+00,4.27E-02,3.19E-01,4,75,"TNFRSF10B,VPS39,UTP4,SNAP25" Transcription Factor Binding Site,V$ARNT_01,V$ARNT_01,TFBS,8.51E-03,1.00E+00,4.27E-02,3.19E-01,7,215,"BDNF,TAC1,ARRDC3,KAT6A,STMN1,PPAT,SNAP25" Transcription Factor Binding Site,CAGCTG_V$AP4_Q5,CAGCTG_V$AP4_Q5,TFBS,8.54E-03,1.00E+00,4.27E-02,3.19E-01,22,1184,"SOX4,ETV5,NR4A1,CITED2,KCNE4,NAV1,CHPF,PMP22,CACNB1,DUSP4,PLEKHA4,NR4A3,PPAT,CRHBP,MIR137HG,RIT1,EGR1,EGR2,TLE4,CELF3,SPRY4,RUNDC1" Transcription Factor Binding Site,M40776,HMBOX1_TARGET_GENES,MSigDB,8.62E-03,1.00E+00,4.29E-02,3.20E-01,22,1185,"HLA-E,NCL,DPP8,RNF43,INKA2,CITED2,CEP170,DST,CIAPIN1,KCNK1,NKTR,FHL2,SMG6,FLT3LG,GPR19,TENT5A,MUS81,LBR,IFRD1,SEC22C,MICAL2,MARF1" Transcription Factor Binding Site,V$GATA_C,V$GATA_C,TFBS,8.72E-03,1.00E+00,4.32E-02,3.22E-01,7,216,"ZNF385B,BDNF,HYAL3,DUSP6,EDN1,CITED4,MAP4K5" Transcription Factor Binding Site,V$CEBP_Q2_01,V$CEBP_Q2_01,TFBS,8.93E-03,1.00E+00,4.38E-02,3.27E-01,7,217,"ETV5,BDNF,ARRDC3,DYRK3,STMN1,CITED4,SPRY4" Transcription Factor Binding Site,V$AREB6_01,V$AREB6_01,TFBS,8.93E-03,1.00E+00,4.38E-02,3.27E-01,7,217,"STRN4,PXN,ARRDC3,VWF,LAMB3,OPHN1,EGR4" Transcription Factor Binding Site,M30379,ZNF7_TARGET_GENES,MSigDB,9.06E-03,1.00E+00,4.42E-02,3.30E-01,18,908,"CLK4,HLA-E,TBC1D2B,CHGA,TRMT10C,PTPRN,DTX4,SYT5,HES1,TAF1,HS3ST2,GPR19,SRSF6,ZNF329,CITED4,OVGP1,TMEM179,PRKAB2" Transcription Factor Binding Site,V$CEBP_01,V$CEBP_01,TFBS,9.15E-03,1.00E+00,4.44E-02,3.31E-01,7,218,"ADM,CACNB1,SRSF6,FOSB,DUSP2,EGR2,MYLIP" Transcription Factor Binding Site,V$ETS2_B,V$ETS2_B,TFBS,9.37E-03,1.00E+00,4.52E-02,3.38E-01,7,219,"CNKSR1,MAPKAPK2,CITED2,RASA3,RBMS2,MIR137HG,EGR1" Transcription Factor Binding Site,V$AHRARNT_02,V$AHRARNT_02,TFBS,9.47E-03,1.00E+00,4.55E-02,3.40E-01,2,14,"HES1,EGR1" Transcription Factor Binding Site,M30140,RBM34_TARGET_GENES,MSigDB,9.52E-03,1.00E+00,4.55E-02,3.40E-01,20,1053,"CHGB,DPP8,INKA2,COX5A,DNM1,FHL2,ZNF367,DYRK3,DOCK2,GPR3,USP30,SRSF6,TNIP2,CHSY1,NR4A3,FAM131A,FADS1,PDP1,MACF1,RUNDC1" Transcription Factor Binding Site,CTCNANGTGNY_UNKNOWN,CTCNANGTGNY_UNKNOWN,TFBS,9.74E-03,1.00E+00,4.63E-02,3.46E-01,4,78,"CITED2,TMPRSS3,MIR137HG,UTP4" Transcription Factor Binding Site,M40732,NUP153_TARGET_GENES,MSigDB,9.90E-03,1.00E+00,4.69E-02,3.50E-01,28,1643,"ATP6V0C,BRPF3,CENPF,SAMD8,TMEM198,KCTD21,INKA2,EPM2AIP1,UBR5,DSTYK,PXN,MCRS1,NKTR,DNM1,CHPF,C17orf80,RAF1,VPS39,PPP1R3B,POT1,SHC1,CNTD1,IFRD1,SEC22C,PRKAB2,MARF1,SERPINB1,MACF1" Transcription Factor Binding Site,M29922,CHAF1B_TARGET_GENES,MSigDB,1.04E-02,1.00E+00,4.88E-02,3.65E-01,19,991,"ETV5,IER5,SSBP2,ISG20,DPP8,ARRDC3,RNU2-2P,SMURF2,DOCK2,SUPT20H,PPP1R3B,DUSP2,DUSP6,KAT6A,EGR1,UTP4,SERPINB1,CEP57,ANKRD33B" Gene Family,925,Granins,genenames.org,6.95E-05,1.03E-02,1.03E-02,5.74E-02,3,8,"CHGA,CHGB,SCG2" Gene Family,895,MAP kinase phosphatases,genenames.org,2.00E-04,2.96E-02,1.44E-02,8.05E-02,3,11,"DUSP2,DUSP4,DUSP6" Gene Family,542,Endogenous ligands,genenames.org,2.93E-04,4.33E-02,1.44E-02,8.05E-02,10,237,"PDYN,SST,BDNF,ADM,FGF2,TAC1,FLT3LG,VWF,RGS2,EDN1" Gene Family,425,Beta 4-glycosyltransferases,genenames.org,7.85E-04,1.16E-01,2.90E-02,1.62E-01,3,17,"B4GALT6,CHPF,CHSY1" Drug,ctd:D010938,Plant Oils,CTD,4.47E-15,1.06E-10,1.06E-10,1.13E-09,33,496,"SPRY2,SAMD8,ANKRD37,ZFAND5,TNFRSF10B,NR4A1,SLC25A25,CITED2,ADM,SLC35F3,ARC,PLAT,HES1,ARRDC3,SPTY2D1,SRSF6,PODXL,FOSB,ZNF652,TENT5A,DUSP2,DUSP6,NR4A2,NR4A3,RGS2,EDN1,RIT1,IFRD1,NACC2,EGR1,EGR2,EGR4,MYLIP" Drug,1520_UP,Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.15E-14,1.70E-09,8.51E-10,9.06E-09,19,154,"SOX4,ZNF184,ETS2,ETV5,IER5,ISG20,TNFRSF10B,NR4A1,ARC,HES1,FOSB,DUSP4,NR4A2,NR4A3,RGS2,LDLR,TGIF1,EGR1,EGR4" Drug,ctd:C568608,PCI 5002,CTD,2.37E-12,5.64E-08,1.66E-08,1.77E-07,36,735,"SAMD8,ANKRD37,NAB2,ETS2,IER5,TNFRSF10B,NR4A1,DPP8,SLC25A25,CITED2,ADM,CKS2,ARC,FGF2,GCC1,MED17,SMURF2,SPTY2D1,FOSB,TENT5A,DUSP2,NR4A2,CHSY1,NR4A3,FAM131A,RGS2,LDLR,EDN1,TGIF1,IFRD1,NACC2,EGR1,EGR2,SPRY4,MYLIP,SNAP25" Drug,3851_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.79E-12,6.63E-08,1.66E-08,1.77E-07,18,165,"SOX4,CLK4,NAB2,IER5,TNFRSF10B,NR4A1,CITED2,ADM,TENT5A,DUSP4,KAT6A,NR4A2,NR4A3,LDLR,EDN1,EGR1,PDP1,MYLIP" Drug,ctd:D017638,"Asbestos, Crocidolite",CTD,7.56E-12,1.80E-07,3.60E-08,3.83E-07,47,1240,"SOX4,SPRY2,CNKSR1,MSC,MAPKAPK2,ISG20,TNFRSF10B,NR4A1,BDNF,CITED2,ADM,CKS2,DST,FGF2,SYT5,MED17,FHL2,HS3ST2,SMURF2,AMIGO2,SEMA3F,RAF1,PPP1R3B,FOSB,DUSP2,DUSP4,DUSP6,SHC1,NR4A2,APEX1,NR4A3,RGS2,LDLR,RGS4,EDN1,RIT1,TGIF1,IFRD1,EGR1,EGR2,EGR4,MAP4K5,PDP1,TLE4,SPRY4,CD59,SNAP25" Drug,1068_UP,thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.05E-11,2.49E-07,4.14E-08,4.41E-07,17,155,"CNKSR1,ETS2,IER5,ISG20,TNFRSF10B,NR4A1,CITED2,HES1,TENT5A,DUSP4,NR4A2,NR4A3,LDLR,FADS1,LRIG1,EGR1,MAP4K5" Drug,1791_UP,Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.43E-11,3.39E-07,4.85E-08,5.16E-07,17,158,"SOX4,SPRY2,WDR33,ETS2,IER5,TNFRSF10B,NR4A1,BDNF,CITED2,ADM,ARC,FOSB,DUSP4,LAMB3,RGS2,EDN1,EGR1" Drug,ctd:D003024,Clozapine,CTD,2.47E-11,5.86E-07,7.33E-08,7.81E-07,25,390,"ACOX1,NCL,CHGA,NR4A1,PFKP,SST,KCNIP3,STX1B,BDNF,STRN4,ARC,FGF2,SYT5,TAC1,NPTX2,FOSB,DUSP6,NR4A2,LDLR,RGS4,CRHBP,OVGP1,EGR1,EGR2,SNAP25" Drug,1486_UP,Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.10E-10,4.98E-06,5.54E-07,5.90E-06,16,162,"SPRY2,ETV5,IER5,ISG20,NR4A1,TMPRSS3,ARC,HES1,DUSP4,NR4A2,NR4A3,RGS2,LDLR,LRIG1,EGR1,SYNGR3" Drug,2525_UP,Strophanthidin [66-28-4]; Up 200; 9.8uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.02E-10,7.18E-06,7.18E-07,7.65E-06,16,166,"WDR33,CLK4,ETS2,IER5,NR4A1,BDNF,FOSB,KAT6A,NR4A2,NR4A3,RGS2,LDLR,RIT1,OVGP1,EGR1,CD59" Drug,ctd:D006220,Haloperidol,CTD,3.79E-10,9.02E-06,8.20E-07,8.73E-06,22,342,"NCL,NR4A1,PFKP,KCNIP3,STX1B,BDNF,STRN4,ARC,TAC1,TAP1,NPTX2,FOSB,DUSP6,NR4A3,RGS2,LDLR,RGS4,CRHBP,EDN1,EGR1,EGR2,SNAP25" Drug,ctd:C051246,1-methylanthracene,CTD,4.66E-10,1.11E-05,9.24E-07,9.85E-06,31,677,"SOX4,SPRY2,ANKRD37,CLK4,ETS2,ETV5,IER5,ZFAND5,KCTD21,NR4A1,SLC25A25,BDNF,INKA2,TRMT10C,FGF2,HES1,SPTY2D1,PPP1R3B,DUSP4,DUSP6,NR4A2,NR4A3,LDLR,EDN1,TGIF1,IFRD1,LRIG1,EGR1,EGR2,SPRY4,MARF1" Drug,6807_UP,Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.87E-10,1.87E-05,1.44E-06,1.53E-05,15,152,"ETS2,ETV5,ISG20,NR4A1,ADM,HES1,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,LDLR,TGIF1,EGR1,EGR4" Drug,2211_UP,Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.45E-10,2.25E-05,1.61E-06,1.71E-05,15,154,"ETS2,ETV5,ISG20,NR4A1,PXN,ARC,CACNB1,FOSB,DUSP4,NR4A2,NR4A3,RGS2,LDLR,EGR1,EGR4" Drug,1010_UP,thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.13E-09,2.69E-05,1.80E-06,1.91E-05,15,156,"CNKSR1,ETS2,ETV5,IER5,ISG20,TNFRSF10B,NR4A1,HES1,DUSP4,NR4A2,RGS2,LDLR,LRIG1,EGR1,SYNGR3" Drug,2651_UP,Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.24E-09,2.95E-05,1.84E-06,1.96E-05,15,157,"ETS2,ETV5,ISG20,NR4A1,FGF2,PLAT,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,LDLR,EGR1,EGR4,HCRTR2" Drug,2192_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.48E-09,3.51E-05,1.98E-06,2.11E-05,15,159,"WDR33,CLK4,NAB2,ETS2,TNFRSF10B,NR4A1,PLSCR4,FOSB,NR4A2,NR4A3,RGS2,LDLR,TRIM3,RIT1,EGR1" Drug,ctd:D003913,Dextroamphetamine,CTD,1.50E-09,3.56E-05,1.98E-06,2.11E-05,16,185,"PDYN,NR4A1,STX1B,BDNF,SCG2,ARC,SYT5,TAC1,FOSB,RGS4,CRHBP,IFRD1,EGR1,BBC3,NPAS4,MYBL1" Drug,2210_UP,Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.61E-09,3.83E-05,2.02E-06,2.15E-05,15,160,"ETS2,ISG20,NR4A1,ARC,HES1,CACNB1,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,RGS2,LDLR,TGIF1,EGR1" Drug,ctd:D003042,Cocaine,CTD,1.91E-09,4.55E-05,2.28E-06,2.42E-05,44,1314,"PCSK2,SYNPO2,GJD2,CLK4,PDYN,IER5,TNFRSF10B,NR4A1,STX1B,BDNF,ITPKB,TRMT10C,COX5A,BASP1,SCG2,ARHGAP29,ARC,FGF2,SYT1,SYT5,TAC1,GCC1,DNM1,HS3ST2,SEMA3F,RAF1,NPTX2,HTR1B,VWF,FOSB,NR4A2,CCT2,RGS2,RGS4,EDN1,TRIM3,OPHN1,IFRD1,NACC2,EGR1,EGR2,AACS,RAB15,HCRTR2" Drug,5936_DN,H-7 dihydrochloride; Down 200; 100uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.05E-09,4.87E-05,2.32E-06,2.47E-05,16,189,"SOX4,CLK4,IER5,ZFAND5,CITED2,BRPF1,HES1,GCC1,MED17,AMIGO2,DYRK2,TENT5A,DUSP4,TGIF1,MYLIP,PLK4" Drug,ctd:C007738,fluoranthene,CTD,2.17E-09,5.17E-05,2.35E-06,2.50E-05,34,851,"SOX4,SPRY2,ANKRD37,CLK4,ETS2,ETV5,IER5,ZFAND5,KCTD21,NR4A1,SLC25A25,BDNF,INKA2,TRMT10C,FGF2,HES1,SPTY2D1,PPP1R3B,DUSP4,DUSP6,NR4A2,APEX1,NR4A3,LDLR,EDN1,TGIF1,IFRD1,LRIG1,EGR1,EGR2,MT-ND1,SPRY4,AACS,MARF1" Drug,3852_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.27E-09,5.40E-05,2.35E-06,2.50E-05,15,164,"CLK4,NAB2,TNFRSF10B,NR4A1,ADM,DUSP4,KAT6A,NR4A2,NR4A3,LDLR,EDN1,EGR1,PDP1,MYLIP,PLK4" Drug,3275_UP,Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.47E-09,5.88E-05,2.45E-06,2.61E-05,15,165,"SOX4,CLK4,IER5,TNFRSF10B,CITED2,ADM,PXN,HES1,TENT5A,DUSP4,NR4A2,LDLR,EDN1,OVGP1,EGR1" Drug,5021_UP,Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.73E-09,8.88E-05,3.29E-06,3.50E-05,15,170,"NAB2,ETV5,GBP1,ISG20,TNFRSF10B,NR4A1,PLAT,CACNB1,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,EGR1,EGR4" Drug,2423_UP,Digoxin [20830-75-5]; Up 200; 5.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.73E-09,8.88E-05,3.29E-06,3.50E-05,15,170,"ETS2,IER5,ZFAND5,NR4A1,BDNF,CKS2,ARC,FOSB,DUSP2,NR4A2,NR4A3,RGS2,LDLR,EGR1,CD59" Drug,3945_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.73E-09,8.88E-05,3.29E-06,3.50E-05,15,170,"SOX4,CLK4,IER5,TNFRSF10B,NR4A1,ADM,FGF2,FOSB,TENT5A,DUSP4,NR4A2,NR4A3,EDN1,EGR1,PDP1" Drug,6048_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.14E-09,1.22E-04,4.36E-06,4.65E-05,15,174,"CLK4,ETV5,NR4A1,ADM,CACNB1,RASA3,FOSB,TENT5A,DUSP4,KAT6A,NR4A2,LDLR,EDN1,EGR1,PDP1" Drug,5779_UP,Ellipticine [519-23-3]; Up 200; 16.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.01E-09,1.67E-04,5.75E-06,6.13E-05,15,178,"CHGA,BDNF,CITED2,ADM,PLPPR4,ARC,LBH,NPTX2,FOSB,TENT5A,NR4A2,RGS4,EDN1,EGR1,EGR4" Drug,312_DN,staurosporine; Down 200; 1uM; MCF7; HG-U133A,Broad Institute CMAP Down,8.81E-09,2.09E-04,6.98E-06,7.44E-05,15,181,"SOX4,IER5,ZFAND5,TNFRSF10B,CITED2,CKS2,HES1,MED17,AMIGO2,DYRK2,TENT5A,LDLR,TGIF1,IFRD1,NACC2" Drug,ctd:D009020,Morphine,CTD,1.09E-08,2.59E-04,8.18E-06,8.72E-05,23,447,"PDYN,SERPINF1,NR4A1,SST,BDNF,NAV1,FGF2,SYT5,TAC1,PLAT,FHL2,RAF1,FOSB,DUSP6,NR4A2,RGS4,ARL4D,EGR1,EGR2,EGR4,SERPINB1,PATJ,BBC3" Drug,5968_DN,H-7 dihydrochloride; Down 200; 100uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,1.10E-08,2.62E-04,8.18E-06,8.72E-05,15,184,"SOX4,ZNF184,IER5,ZFAND5,BRPF1,GCC1,MED17,DYRK2,SUPT20H,TENT5A,RGS2,LDLR,TGIF1,IFRD1,PLK4" Drug,ctd:D008694,Methamphetamine,CTD,1.31E-08,3.11E-04,9.44E-06,1.01E-04,44,1401,"PCSK1,PDYN,NAB2,LGR4,ISG20,NR4A1,SLC25A25,BDNF,C1QL1,CITED2,DST,STRADA,SCG2,ARHGAP29,PXN,ARC,FGF2,TAC1,PLAT,HES1,DNM1,SPTY2D1,NPTX2,GPR19,PODXL,TENT5A,DUSP6,KAT6A,NR4A2,MUS81,NR4A3,CCT2,STMN1,RGS2,RGS4,CITED4,EGR1,EGR2,EGR4,PDP1,NIPAL1,MACF1,BBC3,NPAS4" Drug,4404_UP,Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.39E-08,3.30E-04,9.71E-06,1.04E-04,14,160,"CLK4,IER5,TNFRSF10B,NR4A1,ADM,FOSB,DUSP4,KAT6A,NR4A2,NR4A3,LDLR,EDN1,EGR1,PDP1" Drug,2227_UP,Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.50E-08,3.58E-04,1.02E-05,1.09E-04,14,161,"ETS2,ISG20,NR4A1,ARC,SYT5,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,RGS2,LDLR,EGR1,EGR4" Drug,3771_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.63E-08,3.87E-04,1.05E-05,1.12E-04,14,162,"WDR33,ETS2,GBP1,IER5,NR4A1,CITED2,ADM,ARC,NPTX2,FOSB,NR4A2,EDN1,EGR1,MYLIP" Drug,1339_UP,Digitoxigenin [143-62-4]; Up 200; 10.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.63E-08,3.87E-04,1.05E-05,1.12E-04,14,162,"CLK4,NAB2,ZFAND5,NR4A1,DPP8,CKS2,FOSB,DUSP2,KAT6A,NR4A2,NR4A3,LDLR,RIT1,EGR1" Drug,ctd:D005472,Fluorouracil,CTD,1.76E-08,4.19E-04,1.10E-05,1.17E-04,43,1364,"SOX4,LGR4,IER5,MCM6,NCL,MCCC2,TNFRSF10B,NR4A1,SST,BDNF,INKA2,CITED2,ADM,CKS2,BBX,DST,METRN,SCG2,TSPO,FGF2,PLAT,HES1,FHL2,TAP1,ZNF367,RAF1,SRSF6,PODXL,DUSP6,APEX1,RGS2,RGS4,CRHBP,EDN1,RIT1,FADS1,EGR1,MAP4K5,MYLIP,KIAA0040,MACF1,FUT1,BBC3" Drug,3770_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.06E-08,4.90E-04,1.21E-05,1.29E-04,14,165,"WDR33,ETS2,TNFRSF10B,NR4A1,BDNF,CITED2,ADM,ARC,FOSB,NR4A2,EDN1,EGR1,MYLIP,PRKAB2" Drug,2439_UP,Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.06E-08,4.90E-04,1.21E-05,1.29E-04,14,165,"SOX4,NAB2,IER5,ARC,HES1,FOSB,DUSP2,DUSP4,NR4A2,NR4A3,RGS2,RIT1,EGR1,EGR4" Drug,ctd:C534628,SCH 23390,CTD,2.08E-08,4.95E-04,1.21E-05,1.29E-04,18,285,"PCSK1,NAB2,ARC,PLAT,NPTX2,FOSB,TENT5A,DUSP6,NR4A2,MUS81,NR4A3,RGS2,RGS4,CITED4,EGR1,EGR2,EGR4,NPAS4" Drug,6680_UP,Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.40E-08,5.71E-04,1.36E-05,1.45E-04,14,167,"ZNF136,WDR33,CLK4,ETS2,NR4A1,BDNF,ADM,ARC,FOSB,NR4A2,NR4A3,EDN1,EGR1,MYLIP" Drug,1132_UP,BW-B 70C; Up 200; 31.6uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,2.79E-08,6.64E-04,1.54E-05,1.65E-04,14,169,"SOX4,ETS2,ISG20,TNFRSF10B,NR4A1,HES1,CHPF,DUSP4,ZNF254,FADS1,LRIG1,EGR1,SYNGR3,CEP57" Drug,965_UP,felodipine; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.01E-08,7.16E-04,1.59E-05,1.69E-04,14,170,"ETS2,IER5,ISG20,TNFRSF10B,NR4A1,ADM,ARC,HES1,DUSP4,NR4A2,NR4A3,RGS2,LDLR,EGR1" Drug,5501_UP,Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.01E-08,7.16E-04,1.59E-05,1.69E-04,14,170,"ETV5,IER5,ISG20,TNFRSF10B,NR4A1,HES1,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,TGIF1,EGR1,TLE4" Drug,ctd:D012110,Reserpine,CTD,3.14E-08,7.46E-04,1.62E-05,1.73E-04,12,119,"PCSK1,PCSK2,CHGA,CHGB,BDNF,SCG2,ARC,TAC1,RGS2,LDLR,RGS4,EGR1" Drug,ctd:D020849,Raloxifene Hydrochloride,CTD,3.29E-08,7.82E-04,1.66E-05,1.77E-04,32,857,"MAPKAPK2,PDYN,NCL,SSBP2,ISG20,NR4A1,TMPRSS3,ARHGAP29,LBH,PLAT,FHL2,SMURF2,AMIGO2,DYRK2,PMP22,SEMA3F,VWF,PODXL,DUSP2,DUSP4,DUSP6,APEX1,NR4A3,STMN1,LDLR,RGS4,IFRD1,LRIG1,EGR1,MICAL2,PDP1,MYBL1" Drug,ctd:C518313,"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine",CTD,3.47E-08,8.24E-04,1.72E-05,1.83E-04,5,9,"NR4A1,ARC,FOSB,NR4A3,EGR1" Drug,ctd:D002737,Chloroprene,CTD,3.67E-08,8.73E-04,1.78E-05,1.90E-04,42,1348,"PCSK1,SOX4,MYO1G,SYNPO2,SAMD8,WDR33,ANKRD37,ETV5,GBP1,MCM6,TUBB2B,NR4A1,KCNIP3,SLC25A25,RNF43,BDNF,ADM,CKS2,LYVE1,BBX,TMEM178A,KCNK1,LBH,PLAT,ARRDC3,TAP1,SMURF2,DYRK3,ZNF329,KAT6A,RGS2,RGS4,S1PR3,EVA1C,CORO1A,IFRD1,EGR1,EGR2,MICAL2,SPRY4,NIPAL1,MPZL2" Drug,6451_UP,Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.76E-08,8.93E-04,1.79E-05,1.90E-04,14,173,"ETS2,IER5,TNFRSF10B,INKA2,ADM,PLSCR4,DUSP4,DUSP6,ZNF329,NR4A2,NR4A3,RGS2,EGR1,BBC3" Drug,ctd:D000661,Amphetamine,CTD,4.40E-08,1.05E-03,2.05E-05,2.18E-04,13,148,"PDYN,NR4A1,BDNF,SCG2,ARC,FGF2,TAC1,HTR1B,FOSB,CCT2,RGS2,RGS4,EGR1" Drug,4827_UP,Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.67E-08,1.11E-03,2.13E-05,2.27E-04,14,176,"CLK4,NR4A1,ADM,SP140L,ARC,HES1,FOSB,DUSP6,ZNF329,NR4A2,NR4A3,EGR1,SYNGR3,FUT1" Drug,3887_UP,"Camptothecine (S,+) [7689-03-4]; Up 200; 11.4uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,5.77E-08,1.37E-03,2.59E-05,2.76E-04,14,179,"GP6,SERPINF1,ETS2,IER5,NR4A1,ADM,ARC,GPR3,FOSB,NR4A2,RGS2,EDN1,EGR1,TLE4" Drug,6823_UP,Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.04E-08,1.44E-03,2.66E-05,2.83E-04,13,152,"ETV5,ISG20,NR4A1,ARC,HES1,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,LDLR,TGIF1,EGR1" Drug,4662_UP,Menadione [58-27-5]; Up 200; 23.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.63E-08,1.58E-03,2.82E-05,3.00E-04,14,181,"IER5,NR4A1,CITED2,ADM,ARC,SEMA3F,FOSB,TENT5A,DUSP2,NR4A2,RGS4,ARL4D,EGR1,MYLIP" Drug,1537_UP,Lynestrenol [52-76-6]; Up 200; 14uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.63E-08,1.58E-03,2.82E-05,3.00E-04,14,181,"SPRY2,ETS2,ETV5,ISG20,NR4A1,TMPRSS3,DYRK3,DUSP4,NR4A2,NR4A3,RGS2,EGR1,PLK4,MYBL1" Drug,CID003036508,Pc 12,Stitch,6.87E-08,1.63E-03,2.87E-05,3.05E-04,15,211,"PCSK1,SPRY2,GJD2,CHGA,CHGB,BDNF,SCG2,FGF2,SYT1,RAF1,SHC1,IFRD1,EGR1,SPRY4,SNAP25" Drug,2321_UP,"Camptothecine (S,+) [7689-03-4]; Up 200; 11.4uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,7.11E-08,1.69E-03,2.91E-05,3.10E-04,14,182,"ETS2,IER5,NR4A1,ADM,ARC,HES1,GPR3,FOSB,NR4A2,NR4A3,RGS2,EGR1,TLE4,HCRTR2" Drug,3691_DN,0175029-0000 [211245-78-2]; Down 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,8.15E-08,1.94E-03,3.28E-05,3.50E-04,14,184,"SOX4,ZNF184,IER5,ZFAND5,ADM,MED17,DYRK2,DUSP4,DUSP6,ZNF329,CHSY1,RGS2,LDLR,PLK4" Drug,ctd:D015655,1-Methyl-4-phenylpyridinium,CTD,8.75E-08,2.08E-03,3.47E-05,3.69E-04,47,1657,"CENPF,RNF112,SERPINF1,HLA-E,PSMC5,U2AF2,MCM6,NCL,CHGA,TNFRSF10B,NR4A1,SST,BDNF,TMEFF2,ADM,PTPRN,TMEM178A,SCG2,TSPO,FGF2,LBH,FAM181B,HS3ST2,GPI,RAF1,GPR3,NPTX2,GPR19,SRSF6,DUSP6,PLEKHA4,NR4A2,NR4A3,LBR,S1PR3,ARL4D,RIT1,IFRD1,FADS1,LRIG1,NACC2,EGR1,MT-ND1,FUT1,RBM24,BBC3,HCRTR2" Drug,4163_UP,Trimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.32E-08,2.22E-03,3.63E-05,3.87E-04,14,186,"GP6,ETV5,ISG20,NR4A1,ADM,ARC,FOSB,DUSP4,NR4A2,NR4A3,RGS2,EDN1,EGR1,EGR4" Drug,3386_UP,Propofol [2078-54-8]; Up 200; 22.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.97E-08,2.37E-03,3.77E-05,4.01E-04,14,187,"ETS2,NR4A1,ARC,PLSCR4,GPR3,CACNB1,NPTX2,FOSB,NR4A3,RGS2,EDN1,EGR1,EGR4,MX1" Drug,ctd:D005047,Etoposide,CTD,9.98E-08,2.37E-03,3.77E-05,4.01E-04,25,587,"MSC,CENPF,MAPKAPK2,MATN2,HLA-E,IER5,MCM6,ISG20,TNFRSF10B,BDNF,INKA2,EPM2AIP1,CIAPIN1,FGF2,TAP1,PMP22,TENT5A,DUSP2,DUSP4,APEX1,STMN1,EDN1,CD59,MACF1,BBC3" Drug,4328_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.03E-07,2.44E-03,3.79E-05,4.03E-04,13,159,"WDR33,CLK4,ETS2,IER5,BDNF,ADM,ARC,FOSB,NR4A2,EDN1,OVGP1,EGR1,MYLIP" Drug,CID000066393,"estradiol-2,3-quinone",Stitch,1.04E-07,2.46E-03,3.79E-05,4.03E-04,10,85,"PDYN,SST,SLC25A25,BDNF,CITED2,TAC1,HTR1B,IFRD1,EGR1,MAP4K5" Drug,5275_UP,Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.11E-07,2.63E-03,3.99E-05,4.25E-04,13,160,"CLK4,ETV5,IER5,TNFRSF10B,NR4A1,ADM,DUSP4,KAT6A,NR4A2,NR4A3,EDN1,EGR1,PDP1" Drug,7340_UP,Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.28E-07,3.04E-03,4.54E-05,4.84E-04,13,162,"CLK4,IER5,TNFRSF10B,NR4A1,ADM,TENT5A,DUSP4,KAT6A,NR4A2,LDLR,EDN1,RIT1,EGR1" Drug,1162_UP,Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.68E-07,3.98E-03,5.86E-05,6.24E-04,14,195,"SOX4,WDR33,MAPKAPK2,ACOX1,NAB2,U2AF2,ISG20,TMEM231,DYRK3,NR4A2,NR4A3,CD59,WDFY3,MYBL1" Drug,3283_UP,Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.70E-07,4.05E-03,5.86E-05,6.25E-04,13,166,"WDR33,CLK4,NR4A1,INKA2,ADM,HES1,TENT5A,DUSP4,KAT6A,NR4A2,LDLR,EDN1,EGR1" Drug,5640_UP,Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.83E-07,4.34E-03,6.03E-05,6.42E-04,13,167,"SOX4,CLK4,NAB2,TNFRSF10B,NR4A1,ADM,HES1,TENT5A,DUSP4,NR4A2,LDLR,EDN1,EGR1" Drug,6047_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.83E-07,4.34E-03,6.03E-05,6.42E-04,13,167,"SOX4,CLK4,IER5,NR4A1,ADM,HES1,TENT5A,DUSP4,NR4A2,LDLR,EDN1,EGR1,PDP1" Drug,4801_UP,Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.83E-07,4.34E-03,6.03E-05,6.42E-04,13,167,"CLK4,IER5,TNFRSF10B,NR4A1,ADM,TENT5A,DUSP4,NR4A2,NR4A3,EDN1,RIT1,EGR1,PDP1" Drug,6087_UP,Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.96E-07,4.65E-03,6.37E-05,6.79E-04,13,168,"WDR33,CLK4,TNFRSF10B,ADM,TENT5A,DUSP4,NR4A2,NR4A3,LDLR,EDN1,RIT1,EGR1,PDP1" Drug,ctd:C044887,beta-methylcholine,CTD,2.28E-07,5.43E-03,7.34E-05,7.82E-04,46,1657,"SOX4,SPRY2,BRPF3,SYNPO2,WDR33,RNF112,TBC1D2B,ETV5,SSBP2,CHGA,CHGB,PFKP,EPM2AIP1,ADM,CKS2,TRMT10C,BBX,ANAPC1,STRADA,BRPF1,CIAPIN1,STRN4,MCRS1,ARRDC3,FHL2,DYRK2,SUPT20H,VPS39,PODXL,ZNF652,DUSP6,FSD1,FAM131A,PPAT,LDLR,RGS4,PRMT6,TGIF1,SEC22C,EGR1,CELF3,MYLIP,SNAP25,PHYHIPL,RUNDC1,PLK4" Drug,906_UP,calmidazolium chloride; Up 200; 5uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,2.57E-07,6.11E-03,8.15E-05,8.68E-04,13,172,"ISG20,NR4A1,INKA2,SYT5,HES1,NKTR,RASA3,FOSB,DUSP4,NR4A2,NR4A3,LDLR,EGR1" Drug,2456_UP,Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.94E-07,6.99E-03,9.08E-05,9.67E-04,13,174,"ETS2,ADM,ARC,FOSB,DUSP2,NR4A2,NR4A3,LDLR,EGR1,EGR4,MYLIP,CD59,PLK4" Drug,CID004369084,PNU-107859,Stitch,2.94E-07,6.99E-03,9.08E-05,9.67E-04,13,174,"PCSK1,PCSK2,PDYN,CHGA,CHGB,NR4A1,SST,BDNF,SCG2,VWF,CRHBP,MT-ND1,SNAP25" Drug,3746_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,3.14E-07,7.47E-03,9.57E-05,1.02E-03,13,175,"MAPKAPK2,SSBP2,PLPPR4,LBH,SYT1,DYRK3,PLSCR4,NR4A2,NR4A3,RGS4,EDN1,CORO1A,BBC3" Drug,6463_UP,Fluspirilen [1841-19-6]; Up 200; 8.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.58E-07,8.51E-03,1.08E-04,1.15E-03,13,177,"SPRY2,ISG20,NR4A1,ARC,FOSB,DUSP4,DUSP6,NR4A2,NR4A3,LDLR,EGR1,EGR4,BBC3" Drug,ctd:D013759,Dronabinol,CTD,3.73E-07,8.87E-03,1.11E-04,1.18E-03,31,906,"SOX4,PDYN,SERPINF1,PSMC5,MCM6,NR4A1,KCNIP3,BDNF,TMEFF2,CITED2,CKS2,BBX,PTPRN,SCG2,ARC,TAC1,NKTR,DCLK2,COPS6,DYRK2,GPI,RAF1,VWF,FOSB,DUSP6,CCT2,IFRD1,EGR1,SPRY4,SERPINB1,PATJ" Drug,ctd:C088658,zoledronic acid,CTD,3.96E-07,9.42E-03,1.16E-04,1.24E-03,42,1471,"SOX4,CENPF,HLA-E,TBC1D2B,ETS2,IER5,MCM6,TUBB2B,ZNF385B,TNFRSF10B,KCNIP3,CKS2,BBX,BASP1,TMPRSS3,ARHGAP29,NAV1,FGF2,LBH,PLAT,HES1,ARRDC3,FHL2,RAF1,VWF,DUSP4,DUSP6,LAMB3,STMN1,LDLR,EDN1,OVGP1,FSTL1,EGR1,EGR2,EGR4,TLE4,PRKAB2,CD59,SNAP25,MPZL2,CEP57" Drug,3397_UP,Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.34E-07,1.03E-02,1.23E-04,1.31E-03,13,180,"CLK4,SYNDIG1,TNFRSF10B,CITED2,ADM,DSTYK,TENT5A,DUSP4,NR4A2,LDLR,EDN1,OVGP1,EGR1" Drug,1477_UP,Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.34E-07,1.03E-02,1.23E-04,1.31E-03,13,180,"ETS2,ISG20,TNFRSF10B,NR4A1,ARC,FOSB,DUSP4,ZNF329,NR4A2,NR4A3,RGS2,ARL4D,EGR1" Drug,1937_UP,Azacyclonol [115-46-8]; Up 200; 15uM; PC3; HG-U133A,Broad Institute CMAP Up,4.34E-07,1.03E-02,1.23E-04,1.31E-03,13,180,"SOX4,ISG20,NR4A1,CITED2,ADM,KCNK1,ARC,TENT5A,DUSP6,LDLR,RGS4,OVGP1,EGR1" Drug,5963_DN,H-7 dihydrochloride; Down 200; 100uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,4.63E-07,1.10E-02,1.29E-04,1.38E-03,13,181,"SOX4,CLK4,IER5,ZFAND5,CITED2,GCC1,DYRK2,TENT5A,DUSP4,LDLR,TGIF1,IFRD1,FUT1" Drug,5941_DN,H-7 dihydrochloride; Down 200; 100uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,4.93E-07,1.17E-02,1.36E-04,1.45E-03,13,182,"SOX4,SPRY2,ZNF184,IER5,ZFAND5,ADM,GCC1,MED17,TENT5A,DUSP4,DUSP6,RGS2,LDLR" Drug,5677_UP,Bisacodyl [603-50-9]; Up 200; 11uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.25E-07,1.25E-02,1.43E-04,1.53E-03,13,183,"CLK4,NAB2,IER5,ADM,HS3ST2,FOXF1,DYRK3,TENT5A,DUSP4,NR4A2,EDN1,EGR1,PDP1" Drug,4713_DN,0175029-0000 [211245-78-2]; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,5.58E-07,1.33E-02,1.49E-04,1.59E-03,13,184,"SOX4,CLK4,IER5,ZFAND5,CITED2,HES1,GCC1,AMIGO2,DYRK2,TENT5A,LDLR,TGIF1,IFRD1" Drug,4610_DN,Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,5.58E-07,1.33E-02,1.49E-04,1.59E-03,13,184,"SOX4,CLK4,IER5,ZFAND5,BRPF1,HES1,MED17,DUSP4,DUSP6,CHSY1,RGS2,LDLR,IFRD1" Drug,ctd:C496932,panobinostat,CTD,5.94E-07,1.41E-02,1.57E-04,1.67E-03,39,1333,"PDYN,SERPINF1,SSBP2,ZNF385B,CHGA,TNFRSF10B,PFKP,SST,SLC25A25,RNF43,CITED2,ANOS1,DST,SP140L,TMEM178A,KCNK1,TSPO,NAV1,TAC1,PLAT,DCLK2,AMIGO2,RAF1,FEZF2,PODXL,PPP1R3B,DUSP4,KAT6A,CHSY1,RFX3,S1PR3,EDN1,LRIG1,TLE4,MYLIP,KIAA0040,SNAP25,RBM24,PATJ" Drug,835_UP,carbamazepine; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,7.57E-07,1.80E-02,1.96E-04,2.09E-03,13,189,"SPRY2,CNKSR1,ETS2,ETV5,IER5,ADM,HES1,NR4A2,SP110,RGS2,EGR1,MAP4K5,WDFY3" Drug,1833_UP,Azaguanine-8 [134-58-7]; Up 200; 26.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,7.58E-07,1.80E-02,1.96E-04,2.09E-03,12,159,"SOX4,NAB2,TNFRSF10B,NR4A1,BDNF,FOSB,DUSP2,DUSP4,NR4A2,NR4A3,FAM131A,TGIF1" Drug,1220_UP,SAHA; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.11E-07,1.93E-02,2.03E-04,2.16E-03,12,160,"IER5,TNFRSF10B,BDNF,CITED2,ADM,PLPPR4,SYT1,DYRK3,DUSP6,RGS4,BBC3,MYBL1" Drug,2429_UP,Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.11E-07,1.93E-02,2.03E-04,2.16E-03,12,160,"ETS2,ISG20,NR4A1,BDNF,FOSB,DUSP2,DUSP4,NR4A2,LAMB3,NR4A3,RGS2,EGR1" Drug,5364_UP,Anisomycin [22862-76-6]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.11E-07,1.93E-02,2.03E-04,2.16E-03,12,160,"CLK4,IER5,ISG20,NR4A1,ADM,HES1,FOSB,DUSP6,NR4A3,RGS2,EGR1,EGR4" Drug,CID000003816,NSC759587,Stitch,8.38E-07,1.99E-02,2.08E-04,2.21E-03,20,444,"GP6,GJD2,PDYN,NR4A1,SST,BDNF,SCG2,TSPO,FGF2,SYT1,TAC1,HTR1B,SYNM,FOSB,NR4A2,EGR1,EGR2,EGR4,SNAP25,BBC3" Drug,5439_UP,Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.67E-07,2.06E-02,2.10E-04,2.24E-03,12,161,"SERPINF1,ETS2,ETV5,TNFRSF10B,TENT5A,DUSP4,DUSP6,EDN1,OVGP1,EGR1,SYNGR3,BBC3" Drug,2886_UP,Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.67E-07,2.06E-02,2.10E-04,2.24E-03,12,161,"ETS2,ETV5,TNFRSF10B,NR4A1,ARC,FOSB,DUSP4,NR4A2,NR4A3,RGS2,LDLR,EGR1" Drug,CID009549284,MEK1/2 inhibitor,Stitch,9.60E-07,2.28E-02,2.31E-04,2.46E-03,13,193,"ATP6V0C,ETS2,NCL,NR4A1,BDNF,RAF1,FOSB,DUSP6,NR4A2,RGS2,LDLR,EGR1,BBC3" Drug,ctd:D007608,Kainic Acid,CTD,1.02E-06,2.42E-02,2.42E-04,2.58E-03,13,194,"PDYN,CHGB,NR4A1,SST,BDNF,CITED2,ARC,FGF2,TAC1,NR4A2,APEX1,NR4A3,EGR1" Drug,3963_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.06E-06,2.51E-02,2.48E-04,2.65E-03,12,164,"CLK4,TNFRSF10B,NR4A1,ADM,FOSB,DUSP4,KAT6A,NR4A2,NR4A3,EDN1,EGR1,PDP1" Drug,1234_UP,"Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.28E-06,3.04E-02,2.98E-04,3.17E-03,12,167,"IER5,CITED2,ADM,PLPPR4,SYT1,DYRK3,PLSCR4,DUSP6,NR4A2,RGS4,CORO1A,MYBL1" Drug,ctd:D018967,Risperidone,CTD,1.41E-06,3.36E-02,3.25E-04,3.46E-03,8,65,"CHGA,CHGB,BDNF,RGS2,LDLR,EGR1,EGR2,SNAP25" Drug,CID000004920,17-isoprogesterone,Stitch,1.45E-06,3.45E-02,3.25E-04,3.46E-03,35,1170,"SOX4,PDYN,NAB2,TUBB2B,CHGA,CHGB,NR4A1,SST,BDNF,ADM,TUBB6,LYVE1,UBR5,SCG2,TSPO,FGF2,TAC1,PLAT,PMP22,RAF1,NPTX2,VWF,SRSF6,ZNF652,DUSP6,APEX1,LDLR,EDN1,OVGP1,EGR2,PDP1,SPRY4,MYLIP,MPZL2,CEP57" Drug,2193_UP,Lanatoside C [17575-22-3]; Up 200; 4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.45E-06,3.45E-02,3.25E-04,3.46E-03,12,169,"CLK4,IER5,NR4A1,STRN4,FOSB,KAT6A,NR4A2,NR4A3,LDLR,RIT1,OVGP1,EGR1" Drug,5724_UP,Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.45E-06,3.45E-02,3.25E-04,3.46E-03,12,169,"ETS2,ISG20,CITED2,ADM,ARC,FGF2,SYT1,NR4A2,RGS4,EGR1,SYNGR3,BBC3" Drug,6051_UP,Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.54E-06,3.67E-02,3.33E-04,3.55E-03,12,170,"SOX4,WDR33,ADM,ARHGAP29,TENT5A,DUSP4,ZNF329,NR4A3,EDN1,IFRD1,EGR1,MYBL1" Drug,941_UP,rottlerin; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.54E-06,3.67E-02,3.33E-04,3.55E-03,12,170,"CNKSR1,NAB2,ETS2,ETV5,ISG20,TNFRSF10B,DYRK3,ZNF329,LDLR,TRIM3,TGIF1,EGR1" Drug,1212_UP,"Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.54E-06,3.67E-02,3.33E-04,3.55E-03,12,170,"BDNF,CITED2,ADM,PLPPR4,SYT1,DYRK3,DYRK2,DUSP6,NR4A2,RGS4,CORO1A,MYBL1" Drug,4680_UP,Digoxigenin [1672-46-4]; Up 200; 10.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.54E-06,3.67E-02,3.33E-04,3.55E-03,12,170,"ZNF136,WDR33,CLK4,ETS2,BDNF,ADM,ARC,FOSB,NR4A2,EDN1,EGR1,MYLIP" Drug,ctd:C041786,palm oil,CTD,1.58E-06,3.74E-02,3.37E-04,3.59E-03,45,1719,"SAMD8,MATN2,MCM6,ZFAND5,ZNF385B,ISG20,NR4A1,PFKP,SLC25A25,ITPKB,CITED2,TUBB6,TSPO,NAV1,PLAT,HES1,ARRDC3,FHL2,CNN3,MIEF2,DYRK2,PMP22,PLSCR4,VWF,RASA3,PODXL,PPP1R3B,PLEKHA4,CHSY1,ZNF784,RGS2,RGS4,S1PR3,ARL4D,TGIF1,CORO1A,IFRD1,FSTL1,EGR1,MYLIP,PRKAB2,AACS,SERPINB1,RAB15,BBC3" Drug,887_UP,celastrol; Up 200; 2.5uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.64E-06,3.90E-02,3.42E-04,3.65E-03,12,171,"ETS2,ETV5,IER5,TNFRSF10B,NR4A1,ADM,DUSP6,NR4A2,SP110,RGS2,TGIF1,EGR1" Drug,3297_UP,Bisacodyl [603-50-9]; Up 200; 11uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.64E-06,3.90E-02,3.42E-04,3.65E-03,12,171,"WDR33,CLK4,TNFRSF10B,ADM,TENT5A,DUSP4,KAT6A,NR4A2,NR4A3,LDLR,EDN1,EGR1" Drug,5026_UP,Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.64E-06,3.90E-02,3.42E-04,3.65E-03,12,171,"CLK4,TNFRSF10B,NR4A1,ADM,FOSB,DUSP4,NR4A2,NR4A3,EDN1,RIT1,EGR1,PDP1" Drug,3295_UP,Felodipine [72509-76-3]; Up 200; 10.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.09E-06,4.97E-02,4.32E-04,4.61E-03,12,175,"ETS2,NR4A1,HES1,DUSP4,ZNF329,NR4A2,NR4A3,RGS2,OVGP1,EGR1,EGR4,MICAL2" Drug,ctd:D024483,Vitamin K 3,CTD,2.38E-06,5.65E-02,4.87E-04,5.19E-03,36,1249,"SPRY2,CENPF,ANKRD37,HLA-E,ETS2,IER5,MCM6,ISG20,KCTD21,NR4A1,PFKP,SST,RNF43,CITED2,ANAPC1,HES1,FHL2,DYRK2,VPS39,PODXL,DUSP2,DUSP6,APEX1,CCT2,LBR,LDLR,EDN1,LRIG1,NACC2,EGR1,MICAL2,SPRY4,PRKAB2,SERPINB1,FUT1,BBC3" Drug,CID009996931,"(2S)-4-[[(2S)-1,4-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]amino]-2-[[(3S)-3,4-bis(oxidanyl)-4-oxidanylidene-butyl]amino]butanoic acid",Stitch,2.50E-06,5.95E-02,5.08E-04,5.42E-03,8,70,"ANOS1,COX5A,NPTX2,HTR1B,FEZF2,LDLR,MT-ND1,PLK4" Drug,ctd:D020122,tert-Butylhydroperoxide,CTD,2.56E-06,6.09E-02,5.16E-04,5.50E-03,46,1808,"ANKRD37,MATN2,HLA-E,ETS2,ETV5,PSMC5,MCM6,TUBB2B,ISG20,KCTD21,NR4A1,PFKP,SST,BDNF,CEP170,ADM,DST,TSPO,PXN,SYT1,MCRS1,HES1,NKTR,ARRDC3,FHL2,COPS6,TAP1,AMIGO2,PLSCR4,DOCK2,GPI,DUSP6,POT1,LAMB3,STMN1,LBR,RGS2,LDLR,EDN1,EGR1,PDP1,TLE4,SPRY4,SERPINB1,CEP57,MX1" Drug,4541_UP,"Camptothecine (S,+) [7689-03-4]; Up 200; 11.4uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,2.65E-06,6.30E-02,5.25E-04,5.59E-03,12,179,"ETS2,IER5,NR4A1,CITED2,ADM,GPR3,FOSB,TENT5A,NR4A2,EDN1,EGR1,TLE4" Drug,2656_UP,Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.65E-06,6.30E-02,5.25E-04,5.59E-03,12,179,"SOX4,CLK4,TBC1D2B,IER5,ADM,TENT5A,DUSP4,NR4A2,LDLR,EGR1,PATJ,BBC3" Drug,ctd:D010095,Oxotremorine,CTD,2.80E-06,6.67E-02,5.51E-04,5.87E-03,4,9,"CHGA,CHGB,SCG2,EDN1" Drug,ctd:D009538,Nicotine,CTD,3.01E-06,7.17E-02,5.87E-04,6.26E-03,31,1001,"SERPINF1,PSMC5,CHGA,CHGB,NR4A1,SST,BDNF,ITPKB,CKS2,SCG2,KCNK1,TSPO,ARC,FGF2,PLAT,RAF1,HTR1B,VWF,RASA3,FOSB,DUSP6,APEX1,RGS2,LDLR,EDN1,EGR1,EGR2,AACS,CD59,SERPINB1,PATJ" Drug,7085_DN,GW8510; Down 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,3.15E-06,7.48E-02,6.04E-04,6.43E-03,12,182,"SOX4,SPRY2,CENPF,ZFAND5,EPM2AIP1,MED17,TENT5A,DUSP4,DUSP6,RGS2,TGIF1,PDP1" Drug,3075_UP,Cantharidin [56-25-7]; Up 200; 20.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.15E-06,7.48E-02,6.04E-04,6.43E-03,12,182,"GP6,NR4A1,ARC,PLAT,HES1,NKTR,FOSB,NR4A2,NR4A3,TRIM3,OVGP1,EGR1" Drug,1343_UP,Primaquine diphosphate [63-45-6]; Up 200; 8.8uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.33E-06,7.92E-02,6.34E-04,6.75E-03,12,183,"SOX4,MAPKAPK2,ETS2,INKA2,ADM,FOSB,TNIP2,DUSP2,NR4A3,EGR1,PRKAB2,MX1" Drug,CID000042785,Lupex,Stitch,3.53E-06,8.39E-02,6.62E-04,7.05E-03,10,124,"PCSK1,PCSK2,PDYN,CHGA,CHGB,SST,SCG2,SYT5,TAC1,GPI" Drug,3808_UP,Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.53E-06,8.40E-02,6.62E-04,7.05E-03,11,153,"SOX4,SPRY2,ETS2,BDNF,CITED2,ADM,ARC,FOSB,LAMB3,NR4A3,RGS4" Drug,ctd:C057693,troglitazone,CTD,3.78E-06,8.98E-02,7.02E-04,7.48E-03,37,1329,"CENPF,ANKRD37,ACOX1,SERPINF1,NAB2,MCM6,CHGB,TNFRSF10B,NR4A1,CITED2,ADM,CKS2,NAV1,FGF2,TAF1,FOXF1,RAF1,PODXL,DUSP6,NR4A3,STMN1,SP110,RGS2,LDLR,RGS4,S1PR3,EDN1,IFRD1,CITED4,FADS1,EGR1,MT-ND1,SPRY4,TIMM50,DNAJC5G,FUT1,PLK4" Drug,ctd:C017096,n-butoxyethanol,CTD,4.11E-06,9.77E-02,7.57E-04,8.07E-03,22,581,"SOX4,MYO1G,BRPF3,SERPINF1,ETS2,MCM6,ISG20,NR4A1,ADM,ZNF367,DUSP2,DUSP6,PPAT,RGS2,LDLR,EDN1,IFRD1,FSTL1,EGR1,EGR2,MAP4K5,PLK4" Drug,6764_UP,Anisomycin [22862-76-6]; Up 200; 15uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.54E-06,1.08E-01,8.23E-04,8.77E-03,11,157,"SOX4,SPRY2,ETS2,CITED2,ADM,ARC,FOSB,NR4A2,LAMB3,EDN1,EGR1" Drug,913_UP,forskolin; Up 200; 50uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,4.54E-06,1.08E-01,8.23E-04,8.77E-03,11,157,"ETS2,ISG20,CITED2,ADM,TMPRSS3,CHPF,DUSP4,NR4A2,LRIG1,MARF1,MPZL2" Drug,1209_UP,2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,5.47E-06,1.30E-01,9.84E-04,1.05E-02,12,192,"MAPKAPK2,BDNF,PLPPR4,DTX4,SYT1,DYRK3,SMG6,RASA3,NR4A2,RGS4,CORO1A,BBC3" Drug,ctd:D010656,Phenylephrine,CTD,5.89E-06,1.40E-01,1.05E-03,1.12E-02,20,505,"NAB2,BDNF,ADM,TUBB6,FGF2,TAC1,TAF1,ARRDC3,FHL2,RAF1,FOSB,DUSP6,NR4A3,STMN1,RGS2,LDLR,RGS4,EDN1,EGR1,MYBL1" Drug,1655_UP,thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.13E-06,1.46E-01,1.08E-03,1.15E-02,11,162,"ETS2,ETV5,IER5,ISG20,NR4A1,HES1,DYRK3,DUSP4,NR4A2,LDLR,EGR1" Drug,2658_UP,Anisomycin [22862-76-6]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.13E-06,1.46E-01,1.08E-03,1.15E-02,11,162,"SOX4,WDR33,ISG20,ADM,DUSP4,DUSP6,NR4A3,EDN1,IFRD1,EGR1,MYBL1" Drug,ctd:D004054,Diethylstilbestrol,CTD,6.24E-06,1.48E-01,1.09E-03,1.16E-02,36,1304,"MAPKAPK2,ACOX1,PSMC5,MCM6,TUBB2B,ZFAND5,SSBP2,BDNF,CITED2,CKS2,LYVE1,COX5A,KCNF1,DTX4,TSPO,FGF2,HES1,NKTR,FHL2,DYRK2,GPI,FLT3LG,DUSP6,APEX1,LAMB3,CCT2,STMN1,RGS4,S1PR3,ARL4D,EGR1,EGR2,MICAL2,RBM24,NPAS4,MYBL1" Drug,ctd:D015124,8-Bromo Cyclic Adenosine Monophosphate,CTD,6.62E-06,1.57E-01,1.14E-03,1.22E-02,24,692,"PCSK1,SPRY2,LGR4,ETV5,NR4A1,ITPKB,KCNE4,SCG2,TAC1,PLAT,FHL2,TENT5A,DUSP4,DUSP6,NR4A2,LAMB3,NR4A3,LDLR,CRHBP,FADS1,EGR1,EGR2,MYLIP,PATJ" Drug,ctd:D012834,Silver,CTD,6.63E-06,1.58E-01,1.14E-03,1.22E-02,47,1933,"SOX4,SPRY2,CENPF,TBC1D2B,SSBP2,ISG20,TNFRSF10B,NR4A1,SST,BDNF,CITED2,DTX4,FGF2,TAC1,HS3ST2,TAP1,FOXF1,AMIGO2,SEMA3F,SHROOM3,FEZF2,FOSB,TENT5A,DUSP2,DUSP4,TMEM151B,NR4A2,RGS2,RHO,CNTD1,EGR1,EGR2,EGR4,PDP1,TLE4,SYNGR3,SPRY4,HELZ2,SERPINB1,RAB15,SNAP25,WDFY3,RBM24,KCTD18,NPAS4,MX1,MYBL1" Drug,2952_DN,Betulin [473-98-3]; Down 200; 9uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,6.75E-06,1.60E-01,1.15E-03,1.23E-02,12,196,"NR4A1,DYRK3,PLSCR4,FOSB,DUSP2,DUSP4,ZNF254,NR4A2,NR4A3,EGR1,CD59,MX1" Drug,6190_UP,15d-PGJ2; Up 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,6.90E-06,1.64E-01,1.17E-03,1.25E-02,11,164,"MSC,SYNDIG1,ISG20,ADM,PXN,DUSP4,ZNF329,NR4A2,NR4A3,RIT1,MICAL2" Drug,4573_DN,Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,7.11E-06,1.69E-01,1.20E-03,1.28E-02,12,197,"CENPF,NAB2,GBP1,TNFRSF10B,DTX4,FGF2,SYT1,SEMA3F,GPR3,NR4A2,MAP4K5,PATJ" Drug,ctd:D001554,Benzene,CTD,7.28E-06,1.73E-01,1.22E-03,1.30E-02,28,892,"MAPKAPK2,NAB2,TBC1D2B,ZFAND5,NR4A1,CITED2,UBR5,DSTYK,TAC1,VWF,FOSB,DUSP2,DUSP4,KAT6A,NR4A2,APEX1,NR4A3,FAM131A,RGS2,RIT1,TGIF1,IFRD1,FADS1,EGR1,EGR2,CD59,PATJ,MX1" Drug,ctd:D010894,Piroxicam,CTD,7.39E-06,1.76E-01,1.23E-03,1.31E-02,22,603,"HLA-E,GBP1,MCM6,ISG20,CEP170,ADM,CKS2,ARC,FGF2,PLAT,CNN3,AMIGO2,SRSF6,LAMB3,NR4A3,STMN1,LBR,LDLR,RGS4,TGIF1,PLK4,MX1" Drug,5826_UP,Strophanthidin [66-28-4]; Up 200; 9.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.74E-06,1.84E-01,1.26E-03,1.34E-02,11,166,"CLK4,ETS2,IER5,CITED2,ADM,ARC,FOSB,NR4A2,EDN1,EGR1,MYLIP" Drug,1053_UP,prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,7.74E-06,1.84E-01,1.26E-03,1.34E-02,11,166,"SOX4,ETS2,IER5,ISG20,TNFRSF10B,DYRK3,DUSP4,LDLR,FADS1,EGR1,SYNGR3" Drug,4327_UP,Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.74E-06,1.84E-01,1.26E-03,1.34E-02,11,166,"WDR33,CLK4,ETS2,BDNF,ADM,ARC,NR4A2,EDN1,OVGP1,EGR1,PLK4" Drug,1489_DN,Antipyrine [60-80-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.88E-06,1.87E-01,1.27E-03,1.35E-02,12,199,"NAB2,U2AF2,DSTYK,PXN,CHPF,DYRK3,SEMA3F,FAM131A,LDLR,TRIM3,PATJ,PLK4" Drug,988_UP,"estradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA",Broad Institute CMAP Up,7.88E-06,1.87E-01,1.27E-03,1.35E-02,12,199,"ISG20,TNFRSF10B,DTX4,TMPRSS3,TAF1,FOXF1,DYRK3,ZNF329,RGS2,TRIM3,PATJ,MYBL1" Drug,2927_UP,Sanguinarine [2447-54-3]; Up 200; 12uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.20E-06,1.95E-01,1.31E-03,1.39E-02,11,167,"SOX4,IER5,NR4A1,ARC,HES1,FOSB,TENT5A,DUSP4,NR4A2,NR4A3,EGR1" Drug,ctd:C027576,4-hydroxy-2-nonenal,CTD,8.39E-06,1.99E-01,1.33E-03,1.42E-02,26,799,"PCSK2,SPRY2,PDYN,NAB2,ETS2,GBP1,MCM6,ISG20,TNFRSF10B,NR4A1,BDNF,CKS2,BBX,DST,TAC1,ARRDC3,ZNF367,RAF1,APEX1,STMN1,SP110,RGS2,EDN1,RIT1,BBC3,MX1" Drug,ctd:C051890,irinotecan,CTD,8.61E-06,2.05E-01,1.35E-03,1.44E-02,24,703,"CENPF,MATN2,ETS2,MCCC2,CKS2,MDN1,DST,PTPRN,FGF2,LBH,SYT1,PLAT,HES1,AMIGO2,DYRK2,PMP22,FOSB,DUSP2,DUSP6,RGS4,OPHN1,EGR1,KIAA0040,RBM24" Drug,4454_UP,thioridazine hydrochloride; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.68E-06,2.06E-01,1.35E-03,1.44E-02,11,168,"ETS2,ISG20,NR4A1,KCNK1,ARC,SYT1,AMIGO2,NR4A2,RGS4,EDN1,EGR1" Drug,4365_UP,Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.68E-06,2.06E-01,1.35E-03,1.44E-02,11,168,"SOX4,WDR33,ETS2,ADM,ARHGAP29,TENT5A,DUSP4,ZNF329,NR4A3,EDN1,MYBL1" Drug,4471_UP,Astemizole [68844-77-9]; Up 200; 8.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,9.18E-06,2.18E-01,1.41E-03,1.50E-02,11,169,"ETS2,ISG20,ADM,ARC,FGF2,SYT1,AMIGO2,TENT5A,NR4A2,RGS4,EGR1" Drug,1075_UP,fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,9.18E-06,2.18E-01,1.41E-03,1.50E-02,11,169,"ETS2,ISG20,TNFRSF10B,KCNF1,SUPT20H,DUSP4,LDLR,FADS1,LRIG1,EGR1,MAP4K5" Drug,7063_UP,MG-262; Up 200; 0.1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.71E-06,2.31E-01,1.47E-03,1.57E-02,11,170,"WDR33,ETS2,ETV5,IER5,TNFRSF10B,DUSP2,RGS2,LDLR,IFRD1,EGR1,FUT1" Drug,1656_UP,15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.71E-06,2.31E-01,1.47E-03,1.57E-02,11,170,"ETS2,ETV5,IER5,ZFAND5,TNFRSF10B,ADM,SYNM,ZNF329,LDLR,RIT1,IFRD1" Drug,ctd:D000936,Antigen-Antibody Complex,CTD,1.00E-05,2.39E-01,1.51E-03,1.61E-02,5,24,"NR4A1,FOSB,NR4A2,NR4A3,EGR2" Drug,2723_UP,Cycloheximide [66-81-9]; Up 200; 14.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.03E-05,2.44E-01,1.53E-03,1.62E-02,11,171,"ETS2,GBP1,ISG20,BDNF,SCG2,SYT1,PLAT,DUSP4,NR4A2,NR4A3,RGS2" Drug,3318_UP,Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.03E-05,2.44E-01,1.53E-03,1.62E-02,11,171,"ETS2,ISG20,NR4A1,ARC,FOSB,DUSP4,NR4A2,LAMB3,NR4A3,EGR1,EGR4" Drug,ctd:D005576,Colforsin,CTD,1.05E-05,2.50E-01,1.55E-03,1.65E-02,15,315,"ACOX1,NR4A1,SST,BDNF,NAV1,FGF2,TAC1,RAF1,HTR1B,FOSB,NR4A2,NR4A3,EDN1,FADS1,SNAP25" Drug,ctd:C578491,"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)",CTD,1.07E-05,2.54E-01,1.57E-03,1.67E-02,4,12,"CLK4,DYRK3,DYRK2,SRSF6" Drug,6989_UP,thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.08E-05,2.58E-01,1.58E-03,1.69E-02,11,172,"IER5,ISG20,NR4A1,DUSP4,LDLR,OVGP1,FADS1,LRIG1,EGR1,EGR4,PATJ" Drug,5105_UP,Parthenolide [20554-84-1]; Up 200; 16.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.15E-05,2.72E-01,1.66E-03,1.77E-02,11,173,"NAB2,IER5,CITED2,ADM,ARC,FOSB,TENT5A,NR4A2,EDN1,EGR1,MICAL2" Drug,CID000000951,noradrealine,Stitch,1.18E-05,2.80E-01,1.70E-03,1.81E-02,21,575,"PDYN,SERPINF1,TUBB2B,CHGA,CHGB,SST,BDNF,ADM,COX5A,FGF2,SYT1,TAC1,RAF1,CACNB1,HTR1B,SYNM,EDN1,EGR1,MAP4K5,PDP1,SNAP25" Drug,5613_UP,Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.21E-05,2.88E-01,1.71E-03,1.82E-02,11,174,"ETS2,IER5,TNFRSF10B,NR4A1,ADM,DUSP4,NR4A2,RGS2,RHO,OVGP1,EGR1" Drug,1302_UP,Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.21E-05,2.88E-01,1.71E-03,1.82E-02,11,174,"CLK4,ETS2,NR4A1,CKS2,FOSB,DUSP2,KAT6A,NR4A2,NR4A3,LDLR,EGR1" Drug,5248_UP,Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.21E-05,2.88E-01,1.71E-03,1.82E-02,11,174,"ETS2,ETV5,IER5,ISG20,TNFRSF10B,NR4A1,ADM,NR4A2,NR4A3,RGS2,EGR1" Drug,ctd:D014415,Tunicamycin,CTD,1.30E-05,3.09E-01,1.83E-03,1.95E-02,40,1574,"SOX4,SPRY2,CENPF,ACOX1,SERPINF1,ETS2,ETV5,MCM6,MCCC2,CHGA,TNFRSF10B,PFKP,BASP1,KCNK1,TSPO,HES1,GCC1,NKTR,CHPF,SPTY2D1,CNN3,GPI,RAF1,SHROOM3,NPTX2,DUSP6,STMN1,LDLR,RGS4,RHO,PRMT6,CORO1A,OVGP1,EGR1,MT-ND1,MYLIP,NIPAL1,SNAP25,PHYHIPL,BBC3" Drug,5745_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.42E-05,3.38E-01,1.99E-03,2.12E-02,11,177,"SSBP2,CITED2,ADM,PLPPR4,SYT1,DYRK3,PLSCR4,RGS4,CORO1A,SYNGR3,MYBL1" Drug,ctd:D016291,Dizocilpine Maleate,CTD,1.53E-05,3.63E-01,2.12E-03,2.26E-02,8,89,"SST,BDNF,FGF2,TAC1,PLAT,FOSB,DUSP6,EGR1" Drug,ctd:D011078,Polychlorinated Biphenyls,CTD,1.57E-05,3.73E-01,2.17E-03,2.31E-02,22,633,"SOX4,CENPF,ACOX1,RNF112,ETS2,MCM6,TUBB2B,TUBB6,KCNE4,BASP1,SMG6,GPI,RAF1,FOSB,DUSP6,NR4A2,CHSY1,STMN1,EGR1,EGR2,MACF1,PLK4" Drug,3895_UP,Diethylstilbestrol [56-53-1]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.58E-05,3.75E-01,2.17E-03,2.31E-02,11,179,"ETV5,ISG20,BDNF,ADM,ARC,FOSB,DUSP4,NR4A2,NR4A3,RGS2,EGR1" Drug,ctd:C030935,benz(a)anthracene,CTD,1.65E-05,3.93E-01,2.23E-03,2.38E-02,34,1253,"SOX4,MYO1G,ACOX1,CLK4,ETV5,IER5,MCM6,TNFRSF10B,INKA2,TMEFF2,EPM2AIP1,CITED2,ADM,LYVE1,MDN1,DST,DTX4,MS4A8,PLAT,NKTR,TAF1,TAP1,SMURF2,FOXF1,ZNF367,PMP22,FLT3LG,VPS39,DUSP2,RGS2,EDN1,HELZ2,SERPINB1,ZNF664" Drug,CID000130021,CGP 36742,Stitch,1.66E-05,3.95E-01,2.23E-03,2.38E-02,6,44,"PDYN,SST,BDNF,TSPO,HTR1B,EGR1" Drug,7139_UP,"Chrysene-1,4-quinone [100900-16-1]; Up 200; 15.4uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.66E-05,3.95E-01,2.23E-03,2.38E-02,11,180,"IER5,NR4A1,ADM,ARC,FOSB,TENT5A,DUSP2,NR4A2,EDN1,EGR1,MYLIP" Drug,6340_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.66E-05,3.95E-01,2.23E-03,2.38E-02,11,180,"ETS2,SSBP2,ADM,PLPPR4,SYT1,TENT5A,NR4A2,NR4A3,RGS4,CORO1A,MYBL1" Drug,5419_DN,Methotrexate [59-05-2]; Down 200; 8.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.75E-05,4.16E-01,2.34E-03,2.49E-02,11,181,"SPRY2,CENPF,CKS2,TAF1,GPR19,SRSF6,DUSP2,LBR,LDLR,TLE4,SYNGR3" Drug,ctd:C513635,S-2-pentyl-4-pentynoic hydroxamic acid,CTD,1.76E-05,4.19E-01,2.34E-03,2.50E-02,26,834,"SPRY2,SYNPO2,WDR33,CLK4,TBC1D2B,ETV5,CHGA,PTPRN,KCNK1,ARC,LBH,DNM1,DYRK3,SHROOM3,SUPT20H,RASA3,TNIP2,TGIF1,CITED4,FSTL1,MAP4K5,TLE4,SPRY4,MYLIP,AACS,PHYHIPL" Drug,ctd:D004221,Disulfiram,CTD,1.81E-05,4.30E-01,2.39E-03,2.54E-02,25,785,"ETV5,IER5,TUBB2B,CHGA,BDNF,ADM,ARC,HES1,GCC1,HS3ST2,SPTY2D1,PLSCR4,NPTX2,FOSB,TNIP2,DUSP2,KAT6A,RGS2,LDLR,FSTL1,EGR1,MYLIP,MACF1,ELF2,MX1" Drug,848_UP,felodipine; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.84E-05,4.38E-01,2.42E-03,2.58E-02,11,182,"ETS2,ETV5,IER5,NR4A1,DSTYK,ARC,HES1,C17orf80,DUSP4,NR4A2,EGR1" Drug,4732_UP,Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.94E-05,4.61E-01,2.49E-03,2.66E-02,11,183,"SERPINF1,ISG20,TNFRSF10B,NR4A1,GPR3,RASA3,FOSB,DUSP6,NR4A3,RGS2,EGR1" Drug,2053_UP,Disulfiram [97-77-8]; Up 200; 13.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.94E-05,4.61E-01,2.49E-03,2.66E-02,11,183,"GBP1,IER5,ZFAND5,NR4A1,ADM,ARC,FOSB,DUSP2,NR4A2,LDLR,EGR1" Drug,5530_DN,Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.94E-05,4.61E-01,2.49E-03,2.66E-02,11,183,"SOX4,CITED2,SP140L,HES1,AMIGO2,PMP22,GPR19,ZNF652,DUSP2,NR4A2,SP110" Drug,7059_UP,"Forskolin, from Coleus forskohlii; Up 200; 0.5uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.94E-05,4.61E-01,2.49E-03,2.66E-02,11,183,"MAPKAPK2,ETS2,ISG20,TNFRSF10B,SP140L,CHPF,DYRK3,DUSP4,NR4A2,TRIM3,PATJ" Drug,ctd:D012601,Scopolamine Hydrobromide,CTD,1.96E-05,4.65E-01,2.50E-03,2.67E-02,9,120,"PDYN,NR4A1,BDNF,ARC,TAC1,DUSP6,ARL4D,EGR1,EGR2" Drug,ctd:C009277,sodium arsenate,CTD,2.00E-05,4.74E-01,2.54E-03,2.70E-02,42,1720,"SYNPO2,SAMD8,WDR33,MAPKAPK2,CLK4,GBP1,MCCC2,NR4A1,DPP8,B4GALT6,BDNF,ITPKB,EPM2AIP1,BBX,DST,CIAPIN1,NAV1,ARC,LBH,MCRS1,NKTR,ARRDC3,FOXF1,VWF,SYNM,FOSB,DUSP6,APEX1,CCT2,PPAT,RGS2,ARL4D,CITED4,EGR1,EGR2,SUDS3,MICAL2,SERPINB1,MACF1,RBM24,PATJ,KCTD18" Drug,2696_UP,LY 294002; Up 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.04E-05,4.85E-01,2.57E-03,2.74E-02,11,184,"GP6,ADM,GPR3,DUSP4,DUSP6,NR4A2,NR4A3,EGR1,EGR4,PRKAB2,MYBL1" Drug,5671_DN,Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.04E-05,4.85E-01,2.57E-03,2.74E-02,11,184,"SOX4,IER5,ZFAND5,CITED2,HES1,GCC1,MED17,AMIGO2,LDLR,TGIF1,IFRD1" Drug,ctd:C015001,arsenite,CTD,2.08E-05,4.94E-01,2.60E-03,2.77E-02,42,1723,"PCSK1,PCSK2,SPRY2,MSC,ZNF154,CENPF,MAPKAPK2,ANKRD37,SYNDIG1,TNFRSF10B,NR4A1,SST,BDNF,TMEFF2,C1QL1,CKS2,SLC35F3,NAV1,FGF2,LBH,SYT1,TAC1,PLAT,HES1,TAP1,DOCK2,NPTX2,FEZF2,FOSB,TENT5A,DUSP4,SHC1,APEX1,NR4A3,STMN1,CRHBP,EDN1,IFRD1,SPRY4,ELF2,SNAP25,BBC3" Drug,ctd:D003561,Cytarabine,CTD,2.11E-05,5.02E-01,2.63E-03,2.80E-02,21,598,"MATN2,TNFRSF10B,PFKP,CITED2,CKS2,TSPO,LBH,TAC1,PLAT,PMP22,GPR19,PODXL,TENT5A,DUSP4,RGS4,EDN1,LRIG1,CELF3,MYLIP,PHYHIPL,BBC3" Drug,7498_UP,irinotecan HCl; Up 200; 100uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.15E-05,5.10E-01,2.63E-03,2.80E-02,11,185,"GP6,SERPINF1,IER5,ISG20,ADM,ARC,DYRK3,TENT5A,RGS2,OVGP1,EGR1" Drug,4128_UP,Azacytidine-5 [320-67-2]; Up 200; 16.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.15E-05,5.10E-01,2.63E-03,2.80E-02,11,185,"SOX4,ZNF184,ADM,PLAT,FOXF1,TENT5A,DUSP4,DUSP6,TGIF1,EGR1,FUT1" Drug,7530_UP,irinotecan HCl; Up 200; 100uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.15E-05,5.10E-01,2.63E-03,2.80E-02,11,185,"SPRY2,SERPINF1,ETS2,IER5,ADM,ARC,C17orf80,NR4A2,RGS2,OVGP1,EGR1" Drug,ctd:D003932,Heroin,CTD,2.16E-05,5.13E-01,2.63E-03,2.80E-02,6,46,"PDYN,BDNF,SYT1,NR4A2,SYNGR3,SNAP25" Drug,6793_UP,Nocodazole [31430-18-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.26E-05,5.37E-01,2.72E-03,2.90E-02,11,186,"ETS2,ETV5,ISG20,PXN,SMG6,DUSP4,KAT6A,LDLR,EDN1,TRIM3,PRKAB2" Drug,1334_UP,Myricetin [529-44-2]; Up 200; 12.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.26E-05,5.37E-01,2.72E-03,2.90E-02,11,186,"MAPKAPK2,ACOX1,NAB2,NR4A1,ADM,NKTR,DUSP4,ZNF254,NR4A2,RIT1,PLK4" Drug,ctd:C009250,sevoflurane,CTD,2.36E-05,5.60E-01,2.83E-03,3.01E-02,12,222,"NR4A1,SLC25A25,ARC,FHL2,RAF1,PPP1R3B,DUSP6,EDN1,IFRD1,EGR1,EGR2,NPAS4" Drug,ctd:C004312,glycidol,CTD,2.41E-05,5.74E-01,2.88E-03,3.07E-02,18,466,"TBC1D2B,NR4A1,BDNF,BASP1,ARC,ARRDC3,AMIGO2,SHC1,NR4A2,NR4A3,EDN1,CNTD1,CITED4,EGR4,CELF3,SPRY4,RBM24,NPAS4" Drug,595_UP,resveratrol; Up 200; 50uM; MCF7; HG-U133A,Broad Institute CMAP Up,2.75E-05,6.53E-01,3.24E-03,3.45E-02,11,190,"ETV5,IER5,TNFRSF10B,INKA2,TMEM231,DYRK2,VPS39,LDLR,MARF1,SERPINB1,MYBL1" Drug,7305_UP,Econazole nitrate [24169-02-6]; Up 200; 9uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.75E-05,6.53E-01,3.24E-03,3.45E-02,11,190,"NAB2,CITED2,FGF2,AMIGO2,TENT5A,RGS4,TRIM3,EGR1,TLE4,PATJ,MX1" Drug,ctd:C483909,torcetrapib,CTD,2.75E-05,6.54E-01,3.24E-03,3.45E-02,15,342,"SPRY2,SAMD8,NAB2,NR4A1,BDNF,DST,ARHGAP29,TENT5A,NR4A2,NR4A3,RGS2,EDN1,PDP1,TLE4,RUNDC1" Drug,ctd:C119620,kenpaullone,CTD,2.77E-05,6.59E-01,3.24E-03,3.46E-02,6,48,"NR4A1,CITED2,ADM,PPP1R3B,FOSB,RGS4" Drug,1304_UP,Anisomycin [22862-76-6]; Up 200; 15uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.83E-05,6.72E-01,3.29E-03,3.51E-02,10,157,"ETS2,SSBP2,NR4A1,FOSB,DUSP2,NR4A2,NR4A3,RIT1,IFRD1,EGR1" Drug,ctd:C022838,nickel chloride,CTD,2.92E-05,6.94E-01,3.39E-03,3.61E-02,32,1178,"SOX4,SPRY2,CENPF,ANKRD37,ACOX1,SERPINF1,ETS2,GBP1,MCM6,TUBB2B,NR4A1,CITED2,ADM,CKS2,DST,DSTYK,FGF2,PMP22,GPI,PPP1R3B,FOSB,DUSP6,CHSY1,CCT2,RGS2,LDLR,IFRD1,EGR1,MT-ND1,SERPINB1,BBC3,PLK4" Drug,1011_UP,15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.15E-05,7.49E-01,3.64E-03,3.87E-02,10,159,"ETS2,ETV5,IER5,ZFAND5,TNFRSF10B,ADM,RGS2,LDLR,RIT1,IFRD1" Drug,2896_UP,Mometasone furoate [83919-23-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.32E-05,7.90E-01,3.80E-03,4.05E-02,10,160,"ISG20,TNFRSF10B,NR4A1,DUSP4,NR4A2,RGS2,LDLR,ARL4D,EGR1,MICAL2" Drug,4411_DN,Cyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,3.33E-05,7.91E-01,3.80E-03,4.05E-02,11,194,"SERPINF1,NR4A1,C1QL1,DNM1,SEMA3F,GPR19,SYNM,KAT6A,SP110,TLE4,WDFY3" Drug,ctd:D008775,Methylprednisolone,CTD,3.48E-05,8.28E-01,3.95E-03,4.21E-02,9,129,"GBP1,ISG20,AMIGO2,VWF,LAMB3,NR4A3,RGS4,EDN1,MX1" Drug,6692_UP,Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.49E-05,8.29E-01,3.95E-03,4.21E-02,11,195,"INKA2,LYVE1,SCG2,ARC,RGS4,TRIM3,RHO,EGR1,MICAL2,SNAP25,MX1" Drug,6171_UP,"Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,3.66E-05,8.69E-01,4.04E-03,4.30E-02,11,196,"GP6,NAB2,PXN,TMEM231,AMIGO2,CACNB1,GPR19,NR4A2,NR4A3,TRIM3,CD59" Drug,7511_UP,daunorubicin HCl; Up 200; 1uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.66E-05,8.69E-01,4.04E-03,4.30E-02,11,196,"GBP1,TNFRSF10B,BDNF,CITED2,ADM,SYT5,SMG6,DYRK2,TENT5A,KAT6A,MX1" Drug,7091_UP,"ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,3.66E-05,8.69E-01,4.04E-03,4.30E-02,11,196,"MAPKAPK2,ISG20,RNF43,ADM,DSTYK,C17orf80,PMP22,DUSP2,ZNF329,FAM131A,RGS2" Drug,5777_UP,Spiperone [749-02-0]; Up 200; 10.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.70E-05,8.79E-01,4.04E-03,4.30E-02,10,162,"ETS2,TNFRSF10B,KCNK1,FGF2,SYT1,AMIGO2,FOSB,NR4A2,LAMB3,EDN1" Drug,1069_UP,15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.70E-05,8.79E-01,4.04E-03,4.30E-02,10,162,"ETS2,IER5,ZFAND5,TNFRSF10B,ADM,LDLR,RIT1,IFRD1,EGR1,PRKAB2" Drug,CID000209654,Sv 2,Stitch,3.70E-05,8.79E-01,4.04E-03,4.30E-02,3,6,"CHGA,CHGB,SCG2" Drug,CID000073759,bis(2-pyridylmethyl)amine,Stitch,3.70E-05,8.79E-01,4.04E-03,4.30E-02,3,6,"ADM,DST,TSPO" Drug,CID000005917,pentylenetetrazol,Stitch,3.70E-05,8.80E-01,4.04E-03,4.30E-02,9,130,"PDYN,SST,BDNF,TSPO,DUSP2,DUSP6,EGR1,EGR2,NPAS4" Drug,CID000108185,EXP3174,Stitch,3.74E-05,8.88E-01,4.06E-03,4.32E-02,5,31,"GP6,TAC1,DUSP2,EDN1,EGR1" Drug,1071_UP,rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.83E-05,9.11E-01,4.10E-03,4.37E-02,11,197,"SOX4,MAPKAPK2,STRN4,PXN,GPR19,DUSP4,FADS1,KLHL36,MAP4K5,PATJ,CEP57" Drug,1113_UP,doxycycline; Up 200; 14.4uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.83E-05,9.11E-01,4.10E-03,4.37E-02,11,197,"NAB2,ETS2,CITED2,PXN,COPS6,ZNF254,KLHL36,MICAL2,FUT1,CEP57,MYBL1" Drug,2177_UP,Benfotiamine [22457-89-2]; Up 200; 8.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.83E-05,9.11E-01,4.10E-03,4.37E-02,11,197,"MSC,NR4A1,FGF2,CHPF,CNN3,GPR3,TRIM3,EGR1,KLHL36,SYNGR3,CD59" Drug,ctd:D003345,Corticosterone,CTD,3.93E-05,9.35E-01,4.18E-03,4.46E-02,13,272,"SOX4,PDYN,MCM6,BDNF,ADM,CKS2,TSPO,SYNM,PODXL,STMN1,EDN1,CD59,PLK4" Drug,ctd:C016101,shikonin,CTD,3.94E-05,9.37E-01,4.18E-03,4.46E-02,6,51,"NR4A1,FOSB,DUSP6,NR4A2,NR4A3,EGR2" Drug,2158_UP,"Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Up 200; 11.8uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,4.01E-05,9.54E-01,4.20E-03,4.48E-02,11,198,"ISG20,BDNF,C1QL1,GPR3,GPR19,FOSB,DUSP4,NR4A2,LAMB3,TRIM3,KLHL36" Drug,2518_UP,Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,4.01E-05,9.54E-01,4.20E-03,4.48E-02,11,198,"GJD2,SSBP2,C1QL1,SCG2,HS3ST2,RASA3,NR4A3,FSD1,MICAL2,RAB15,PLK4" Drug,3756_DN,Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,4.01E-05,9.54E-01,4.20E-03,4.48E-02,11,198,"CENPF,TNFRSF10B,NR4A1,SYT1,DYRK2,SUPT20H,KAT6A,CORO1A,KLHL36,WDFY3,PATJ" Drug,7188_UP,Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.10E-05,9.75E-01,4.28E-03,4.56E-02,10,164,"ETS2,IER5,ISG20,TNFRSF10B,DUSP4,NR4A2,RGS2,LDLR,TGIF1,EGR1" Drug,ctd:D000001,Calcimycin,CTD,4.17E-05,9.92E-01,4.33E-03,4.62E-02,9,132,"NR4A1,RAF1,FOSB,DUSP6,NR4A2,NR4A3,EDN1,EGR1,EGR2" Drug,5227_UP,thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.32E-05,1.00E+00,4.47E-03,4.76E-02,10,165,"ETS2,ETV5,IER5,ISG20,INKA2,CACNB1,DUSP4,NR4A2,EGR1,BBC3" Drug,1685_UP,Imipramine hydrochloride [113-52-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.40E-05,1.00E+00,4.52E-03,4.81E-02,11,200,"NAB2,ETV5,NR4A1,B4GALT6,CITED2,GPR3,DUSP2,DUSP4,FSD1,WDFY3,PLK4" Drug,ctd:C031895,lead chromate,CTD,4.41E-05,1.00E+00,4.52E-03,4.81E-02,6,52,"NR4A1,FOSB,DUSP6,NR4A2,EGR1,EGR2" Drug,5324_UP,Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.55E-05,1.00E+00,4.60E-03,4.90E-02,10,166,"CLK4,TNFRSF10B,NR4A1,ADM,FOSB,DUSP4,NR4A2,EDN1,RIT1,EGR1" Drug,3518_UP,Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.55E-05,1.00E+00,4.60E-03,4.90E-02,10,166,"SERPINF1,ETV5,TNFRSF10B,INKA2,TENT5A,DUSP4,DUSP6,FAM131A,TGIF1,EGR1" Drug,956_UP,5224221; Up 200; 12uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,4.55E-05,1.00E+00,4.60E-03,4.90E-02,10,166,"WDR33,ETS2,ETV5,ISG20,TNFRSF10B,ADM,ZNF329,TGIF1,IFRD1,FUT1" Drug,ctd:C090413,N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide,CTD,4.90E-05,1.00E+00,4.93E-03,5.26E-02,4,17,"NR4A1,ARC,HTR1B,FOSB" Drug,ctd:C086401,pentabromodiphenyl ether,CTD,4.97E-05,1.00E+00,4.98E-03,5.31E-02,33,1267,"SPRY2,CLK4,NAB2,ETV5,PSMC5,GBP1,NR4A1,SLC25A25,BDNF,CITED2,KCNE4,BASP1,PXN,TAC1,ARRDC3,DNM1,FHL2,TAP1,CNN3,DOCK2,DUSP4,NR4A2,CCT2,STMN1,RGS4,CRHBP,RHO,CORO1A,IFRD1,EGR1,CD59,RAB15,MX1" Drug,1649_UP,trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.03E-05,1.00E+00,5.01E-03,5.33E-02,10,168,"MAPKAPK2,ETS2,ISG20,TNFRSF10B,NR4A1,CACNB1,DUSP4,NR4A2,RGS2,EGR1" Drug,5310_UP,Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.03E-05,1.00E+00,5.01E-03,5.33E-02,10,168,"CLK4,ETS2,TNFRSF10B,ADM,GCC1,TGIF1,IFRD1,EGR1,SYNGR3,MYBL1" Drug,ctd:C016104,sodium bichromate,CTD,5.27E-05,1.00E+00,5.20E-03,5.54E-02,39,1616,"MYO1G,MAPKAPK2,ACOX1,ETS2,ETV5,MCM6,NCL,ISG20,MCCC2,NR4A1,CITED2,TUBB6,DST,UBR5,CIAPIN1,TSPO,TAP1,CNN3,ZNF367,DYRK3,DOCK2,RAF1,PPP1R3B,DUSP2,DUSP6,APEX1,LAMB3,CCT2,TGIF1,CORO1A,IFRD1,FADS1,EGR1,PDP1,UTP4,MYLIP,SERPINB1,PATJ,PLK4" Drug,6948_UP,15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.29E-05,1.00E+00,5.20E-03,5.54E-02,10,169,"IER5,ZFAND5,TNFRSF10B,GCC1,C17orf80,DYRK3,ZNF329,RIT1,IFRD1,EGR1" Drug,2691_UP,15d-PGJ2; Up 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,5.29E-05,1.00E+00,5.20E-03,5.54E-02,10,169,"SOX4,IER5,ADM,HES1,SYNM,DUSP4,RIT1,IFRD1,EGR1,CD59" Drug,ctd:C018637,phorone,CTD,5.44E-05,1.00E+00,5.30E-03,5.64E-02,8,106,"SPRY2,CLK4,SLC25A25,CIAPIN1,NTMT1,PPAT,IFRD1,FUT1" Drug,ctd:D011188,Potassium,CTD,5.44E-05,1.00E+00,5.30E-03,5.64E-02,8,106,"PDYN,NR4A1,SST,BDNF,KCNK1,TAC1,EDN1,EGR1" Drug,1167_UP,17-AAG; Up 200; 1uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,5.56E-05,1.00E+00,5.40E-03,5.75E-02,10,170,"WDR33,NAB2,ETV5,ISG20,NR4A1,PMP22,DUSP4,NR4A2,NR4A3,PRKAB2" Drug,5247_UP,Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.84E-05,1.00E+00,5.65E-03,6.02E-02,10,171,"CLK4,ZNF184,ADM,SP140L,HES1,DUSP6,NR4A3,RGS2,EGR1,SYNGR3" Drug,ctd:D002713,Chlorine,CTD,6.14E-05,1.00E+00,5.91E-03,6.30E-02,15,367,"ATP6V0C,PSMC5,NR4A1,SST,STX1B,FGF2,PLAT,CNN3,PMP22,APEX1,NR4A3,EDN1,EGR1,RAB15,SNAP25" Drug,ctd:C558013,NSC 689534,CTD,6.25E-05,1.00E+00,5.99E-03,6.38E-02,38,1570,"SOX4,CENPF,ANKRD37,MATN2,IER5,MCM6,ISG20,MCCC2,TNFRSF10B,C1QL1,ADM,DST,COX5A,ANAPC1,TMEM178A,ARC,SYT1,PLAT,FHL2,DYRK3,PLSCR4,SYNM,PODXL,PPP1R3B,LAMB3,STMN1,RGS4,EDN1,RIT1,EVA1C,TGIF1,IFRD1,EGR1,PDP1,MYLIP,PRKAB2,RBM24,MPZL2" Drug,ctd:D009151,Mustard Gas,CTD,6.35E-05,1.00E+00,6.07E-03,6.46E-02,34,1340,"PCSK1,PCSK2,MAPKAPK2,ETS2,GBP1,IER5,MCM6,ISG20,TNFRSF10B,B4GALT6,BDNF,ADM,CKS2,SCG2,FGF2,LBH,TAC1,PLAT,HES1,PMP22,RAF1,PODXL,TENT5A,LAMB3,NR4A3,PPAT,RGS2,EDN1,EGR1,EGR2,SPRY4,PATJ,PLK4,MX1" Drug,CID000643007,C068244,Stitch,6.41E-05,1.00E+00,6.08E-03,6.48E-02,3,7,"PART1,LDLR,EDN1" Drug,7285_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,6.44E-05,1.00E+00,6.08E-03,6.48E-02,10,173,"MAPKAPK2,SSBP2,CITED2,ADM,PLPPR4,SYT1,PLSCR4,RGS4,CORO1A,MYBL1" Drug,949_UP,5255229; Up 200; 13uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,6.44E-05,1.00E+00,6.08E-03,6.48E-02,10,173,"NAB2,ETS2,IER5,NR4A1,DUSP4,NR4A2,NR4A3,SP110,LDLR,EGR1" Drug,CID000031782,AC1L1MBN,Stitch,6.75E-05,1.00E+00,6.33E-03,6.74E-02,7,81,"GBP1,CHGA,TAC1,PLAT,PMP22,LBR,SPRY4" Drug,4243_UP,Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.76E-05,1.00E+00,6.33E-03,6.74E-02,10,174,"CLK4,ETS2,BDNF,CITED2,ADM,HES1,FOSB,EDN1,OVGP1,EGR1" Drug,7245_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,7.09E-05,1.00E+00,6.56E-03,6.99E-02,10,175,"ETS2,IER5,CITED2,ADM,SYT1,NR4A2,RGS4,ARL4D,CORO1A,MYBL1" Drug,909_UP,HC toxin from Helminthosporium carbonum; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,7.09E-05,1.00E+00,6.56E-03,6.99E-02,10,175,"ETV5,SSBP2,CITED2,ADM,DYRK3,PMP22,NR4A2,ARL4D,CORO1A,PDP1" Drug,4436_UP,"Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,7.09E-05,1.00E+00,6.56E-03,6.99E-02,10,175,"SSBP2,NR4A1,PLPPR4,SYT1,DYRK3,RGS4,EDN1,CORO1A,LRIG1,MYBL1" Drug,6896_UP,scriptaid; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.44E-05,1.00E+00,6.86E-03,7.30E-02,10,176,"SSBP2,NR4A1,ADM,PLPPR4,SYT1,NR4A2,RGS4,TRIM3,CORO1A,SYNGR3" Drug,ctd:D005473,Fluoxetine,CTD,7.50E-05,1.00E+00,6.89E-03,7.34E-02,14,331,"PDYN,BDNF,ARC,FGF2,HES1,FHL2,NPTX2,HTR1B,FOSB,NR4A2,NR4A3,ARL4D,EGR1,EGR4" Drug,ctd:D019284,Thapsigargin,CTD,7.56E-05,1.00E+00,6.91E-03,7.36E-02,34,1352,"SPRY2,CENPF,SERPINF1,ETV5,MCM6,MCCC2,CHGA,TNFRSF10B,PFKP,ADM,BASP1,SCG2,KCNK1,TSPO,TAC1,TAF1,CHPF,CNN3,SMG6,RAF1,SHROOM3,FOSB,DUSP6,NR4A2,STMN1,LDLR,CORO1A,EGR1,EGR2,MT-ND1,NIPAL1,MACF1,BBC3,PLK4" Drug,1951_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A",Broad Institute CMAP Up,7.80E-05,1.00E+00,7.03E-03,7.49E-02,10,177,"ETV5,BDNF,CITED2,SYT1,DYRK3,PLSCR4,DUSP6,RGS4,ARL4D,MYBL1" Drug,1645_UP,SAHA; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.80E-05,1.00E+00,7.03E-03,7.49E-02,10,177,"ETV5,SSBP2,ADM,DYRK3,PMP22,RGS2,ARL4D,CORO1A,EGR1,PDP1" Drug,ctd:D017371,8-Hydroxy-2-(di-n-propylamino)tetralin,CTD,7.82E-05,1.00E+00,7.03E-03,7.49E-02,4,19,"PDYN,NR4A1,ARC,FOSB" Drug,CID000070905,B-13,Stitch,7.82E-05,1.00E+00,7.03E-03,7.49E-02,4,19,"PCSK1,PCSK2,PDYN,SYNM" Drug,ctd:D014810,Vitamin E,CTD,7.83E-05,1.00E+00,7.03E-03,7.49E-02,38,1587,"SOX4,GP6,SERPINF1,HLA-E,ETS2,GBP1,SYNDIG1,TUBB2B,ZFAND5,PFKP,ITPKB,CEP170,BBX,FGF2,MCRS1,PLAT,HES1,NKTR,CHPF,COPS6,SMURF2,SMG6,GPI,RAF1,VWF,VPS39,APEX1,PPAT,RGS2,ARL4D,OVGP1,NACC2,EGR1,MAP4K5,MACF1,SNAP25,CEP57,MX1" Drug,CID000128904,SN-6999,Stitch,7.88E-05,1.00E+00,7.04E-03,7.50E-02,5,36,"FHL2,PART1,EGR1,EGR2,EGR4" Drug,4217_UP,Digitoxigenin [143-62-4]; Up 200; 10.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.57E-05,1.00E+00,7.54E-03,8.04E-02,10,179,"ADM,ARC,HS3ST2,FOSB,NR4A2,EDN1,RHO,EGR1,MYLIP,PLK4" Drug,5489_UP,Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.57E-05,1.00E+00,7.54E-03,8.04E-02,10,179,"GBP1,ARC,FOSB,DUSP4,NR4A2,NR4A3,LDLR,TGIF1,EGR1,WDFY3" Drug,1891_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A",Broad Institute CMAP Up,8.57E-05,1.00E+00,7.54E-03,8.04E-02,10,179,"LGR4,IER5,SSBP2,CITED2,SYT1,DYRK3,DUSP6,RGS4,ARL4D,MYBL1" Drug,6711_UP,Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.57E-05,1.00E+00,7.54E-03,8.04E-02,10,179,"CLK4,ETS2,IER5,RNF43,ADM,SCG2,AMIGO2,TENT5A,NR4A2,EDN1" Drug,ctd:D004128,Dimethylnitrosamine,CTD,8.70E-05,1.00E+00,7.63E-03,8.13E-02,25,865,"ETS2,PSMC5,MCM6,ISG20,TNFRSF10B,NR4A1,PFKP,TUBB6,TMEM178A,TSPO,LBH,PLAT,FHL2,TAP1,RAF1,PPP1R3B,DUSP6,SHC1,APEX1,CHSY1,STMN1,RGS2,IFRD1,FSTL1,SERPINB1" Drug,4072_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,8.97E-05,1.00E+00,7.76E-03,8.26E-02,10,180,"SSBP2,PLPPR4,SYT1,PLSCR4,SEMA3F,NR4A2,NR4A3,RGS4,CORO1A,SYNGR3" Drug,3787_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,8.97E-05,1.00E+00,7.76E-03,8.26E-02,10,180,"SSBP2,PLPPR4,LBH,SYT1,DYRK3,PLSCR4,RGS4,CORO1A,LRIG1,SYNGR3" Drug,958_UP,resveratrol; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,8.97E-05,1.00E+00,7.76E-03,8.26E-02,10,180,"ETS2,IER5,ISG20,TNFRSF10B,ADM,DYRK3,SP110,LDLR,EGR1,BBC3" Drug,4641_UP,GBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.97E-05,1.00E+00,7.76E-03,8.26E-02,10,180,"SOX4,CITED2,ADM,ARC,TENT5A,NR4A2,TRIM3,TGIF1,EGR1,MX1" Drug,CID010197840,"(3S,4R,5R)-5-methylolpiperidine-2,3,4-triol",Stitch,9.02E-05,1.00E+00,7.77E-03,8.27E-02,5,37,"NCL,CHGB,UBR5,SCG2,EGR2" Drug,ctd:C029938,nickel sulfate,CTD,9.28E-05,1.00E+00,7.96E-03,8.48E-02,38,1600,"MSC,ZNF154,MAPKAPK2,ZNF184,MIF4GD,ETS2,GBP1,SSBP2,NR4A1,STX1B,EPM2AIP1,CITED2,ADM,SCG2,FGF2,PLAT,HES1,DCLK2,TAP1,PLSCR4,FLT3LG,DUSP4,NR4A2,LAMB3,LBR,S1PR3,EDN1,RIT1,EVA1C,TGIF1,IFRD1,EGR1,KLHL36,TLE4,MYLIP,PRKAB2,RBM24,MX1" Drug,CID000005753,corticosterone,Stitch,9.33E-05,1.00E+00,7.98E-03,8.50E-02,15,381,"PCSK1,PCSK2,PDYN,NR4A1,SST,BDNF,ADM,ANOS1,TSPO,TAC1,HTR1B,SYNM,CRHBP,EDN1,EGR1" Drug,5802_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,9.39E-05,1.00E+00,8.01E-03,8.53E-02,10,181,"ADM,PLPPR4,SYT1,DYRK3,PLSCR4,NR4A2,RGS4,EDN1,CORO1A,MYBL1" Drug,ctd:D013849,Thimerosal,CTD,9.73E-05,1.00E+00,8.23E-03,8.77E-02,31,1199,"PCSK2,FAM168B,MAPKAPK2,ANKRD37,CLK4,HLA-E,NR4A1,PFKP,RNF43,TMEFF2,CITED2,ADM,DST,ARC,HES1,ARRDC3,MED17,SEMA3F,GPI,PPP1R3B,FOSB,KAT6A,NR4A2,FADS1,MAP4K5,TLE4,SYNGR3,PRKAB2,SNAP25,WDFY3,FUT1" Drug,593_UP,geldanamycin; Up 200; 1uM; MCF7; HG-U133A,Broad Institute CMAP Up,9.83E-05,1.00E+00,8.23E-03,8.77E-02,10,182,"MAPKAPK2,ETV5,ZFAND5,DYRK2,GPR3,VPS39,SHC1,RGS2,LDLR,KLHL36" Drug,5010_UP,Prochlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.83E-05,1.00E+00,8.23E-03,8.77E-02,10,182,"ISG20,RNF43,SYT5,PLAT,GPR3,DUSP4,KAT6A,NR4A2,SP110,FUT1" Drug,1280_UP,Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,9.83E-05,1.00E+00,8.23E-03,8.77E-02,10,182,"WDR33,ISG20,NR4A1,DSTYK,DUSP4,NR4A2,NR4A3,FAM131A,TLE4,PLK4" Drug,5354_DN,Mitoxantrone dihydrochloride [70476-82-3]; Down 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,9.83E-05,1.00E+00,8.23E-03,8.77E-02,10,182,"CLK4,IER5,ZFAND5,CITED2,HES1,MED17,AMIGO2,LDLR,TGIF1,IFRD1" Drug,CID000062706,saran,Stitch,1.03E-04,1.00E+00,8.47E-03,9.02E-02,5,38,"ETS2,MCRS1,DYRK2,MPZL2,MX1" Drug,5221_UP,trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.03E-04,1.00E+00,8.47E-03,9.02E-02,10,183,"ETS2,ISG20,LYVE1,PLAT,DUSP4,NR4A3,SP110,LRIG1,EGR1,BBC3" Drug,7062_DN,GW8510; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.03E-04,1.00E+00,8.47E-03,9.02E-02,10,183,"SOX4,CENPF,CLK4,ZFAND5,CITED2,GCC1,AMIGO2,DYRK2,TGIF1,IFRD1" Drug,1141_UP,AG-1478; Up 200; 31.6uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.03E-04,1.00E+00,8.47E-03,9.02E-02,10,183,"ZNF184,ETS2,TNFRSF10B,HES1,TMEM231,CHPF,IFRD1,EGR1,SYNGR3,MARF1" Drug,7084_UP,MS-275; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.03E-04,1.00E+00,8.47E-03,9.02E-02,10,183,"ETS2,ISG20,BDNF,CITED2,PLPPR4,SYT1,PMP22,PLSCR4,DUSP6,RGS4" Drug,CID000002826,pseudococaine,Stitch,1.04E-04,1.00E+00,8.52E-03,9.08E-02,19,570,"PDYN,NAB2,NR4A1,BDNF,FGF2,TAC1,PLAT,GCC1,NPTX2,HTR1B,FOSB,DUSP2,NR4A2,NR4A3,CCT2,RGS2,CRHBP,EDN1,EGR1" Drug,7074_UP,MS-275; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.08E-04,1.00E+00,8.76E-03,9.34E-02,10,184,"CITED2,PLPPR4,SYT1,DYRK3,PMP22,PLSCR4,DUSP6,RGS4,SYNGR3,SERPINB1" Drug,1540_UP,Perphenazine [58-39-9]; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.08E-04,1.00E+00,8.76E-03,9.34E-02,10,184,"SOX4,ISG20,NR4A1,C1QL1,DYRK3,DUSP4,LAMB3,LDLR,OVGP1,EGR1" Drug,ctd:D011189,Potassium Chloride,CTD,1.09E-04,1.00E+00,8.87E-03,9.45E-02,8,117,"BDNF,SCG2,SYT5,TAC1,PLAT,NR4A2,EDN1,SNAP25" Drug,2215_UP,Disulfiram [97-77-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.13E-04,1.00E+00,9.07E-03,9.67E-02,10,185,"NR4A1,PXN,ZNF652,NR4A2,NR4A3,RGS2,TRIM3,EGR1,EGR4,WDFY3" Drug,1215_UP,prochlorperazine dimaleate salt; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.13E-04,1.00E+00,9.07E-03,9.67E-02,10,185,"MAPKAPK2,KCNK1,SYT1,C17orf80,NR4A2,RGS4,EGR1,MICAL2,PATJ,BBC3" Drug,ctd:D008770,Methylnitrosourea,CTD,1.16E-04,1.00E+00,9.29E-03,9.90E-02,14,345,"SPRY2,MSC,PFKP,BDNF,SCG2,TSPO,SMG6,TNIP2,SHC1,STMN1,TGIF1,IFRD1,CD59,PATJ" Drug,CID000104014,PRO-ILE,Stitch,1.17E-04,1.00E+00,9.29E-03,9.90E-02,5,39,"PDYN,SST,BDNF,TAC1,CRHBP" Drug,2218_UP,Isoconazole [27523-40-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.18E-04,1.00E+00,9.29E-03,9.90E-02,10,186,"NR4A1,PXN,CACNB1,DUSP4,NR4A2,NR4A3,RGS2,TRIM3,LRIG1,EGR1" Drug,966_DN,retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Down,1.18E-04,1.00E+00,9.29E-03,9.90E-02,10,186,"MAPKAPK2,NAB2,SSBP2,KCNK1,ZNF160,SYNM,PODXL,MUS81,LRIG1,MYBL1" Drug,ctd:D019324,beta-Naphthoflavone,CTD,1.18E-04,1.00E+00,9.29E-03,9.90E-02,24,829,"A1BG,IER5,ISG20,ITPKB,CITED2,ADM,TUBB6,BASP1,DNM1,FHL2,CHPF,CNN3,PMP22,VWF,DUSP6,PLEKHA4,LAMB3,STMN1,RGS4,RIT1,FADS1,FSTL1,EGR1,SERPINB1" Drug,2448_UP,Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.18E-04,1.00E+00,9.29E-03,9.90E-02,9,151,"IER5,ISG20,NR4A1,GCC1,DUSP4,NR4A2,LAMB3,NR4A3,PLK4" Drug,CID006323466,DB08375,Stitch,1.18E-04,1.00E+00,9.29E-03,9.90E-02,4,21,"A1BG,COX5A,SYNM,APEX1" Drug,CID003082858,Dcfpe,Stitch,1.18E-04,1.00E+00,9.29E-03,9.90E-02,4,21,"PDYN,BDNF,TMEFF2,RHO" Drug,2656_DN,Strophantine octahydrate [11018-89-6]; Down 200; 5.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.23E-04,1.00E+00,9.59E-03,1.02E-01,10,187,"ACOX1,ZNF184,BBX,MCRS1,AMIGO2,GPR19,POT1,IFRD1,MICAL2,CEP57" Drug,1070_UP,troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.23E-04,1.00E+00,9.59E-03,1.02E-01,10,187,"ISG20,TNFRSF10B,ZNF160,C17orf80,DUSP4,POT1,LDLR,FADS1,EGR1,MAP4K5" Drug,ctd:D010126,Ozone,CTD,1.24E-04,1.00E+00,9.61E-03,1.02E-01,32,1272,"A1BG,ATP6V0C,CENPF,PSMC5,IER5,MCM6,NR4A1,SST,KCNIP3,STX1B,BDNF,ADM,KCNE4,KCNK1,FGF2,TAC1,PLAT,CNN3,PMP22,GPI,VWF,APEX1,NR4A3,LDLR,EDN1,IFRD1,EGR1,EGR2,RAB15,SNAP25,PHYHIPL,PLK4" Drug,ctd:D001241,Aspirin,CTD,1.26E-04,1.00E+00,9.79E-03,1.04E-01,21,678,"PCSK1,GP6,ETS2,MCM6,TNFRSF10B,STRN4,PXN,PLAT,SMURF2,RAF1,FOSB,DUSP6,NR4A3,LDLR,TGIF1,EGR1,EGR4,MT-ND1,SERPINB1,BBC3,MX1" Drug,2239_UP,Nocodazole [31430-18-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.29E-04,1.00E+00,9.82E-03,1.05E-01,10,188,"ETS2,ISG20,NR4A1,ADM,PLSCR4,CACNB1,DUSP4,LDLR,EDN1,EGR1" Drug,5493_UP,Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.29E-04,1.00E+00,9.82E-03,1.05E-01,10,188,"ETV5,ISG20,TMPRSS3,FGF2,DUSP4,DUSP6,RGS2,ARL4D,OVGP1,EGR1" Drug,3701_UP,Methotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.29E-04,1.00E+00,9.82E-03,1.05E-01,10,188,"NAB2,TNFRSF10B,DSTYK,SYT1,NR4A2,LDLR,RGS4,EDN1,RIT1,EGR1" Drug,ctd:C000499,ferric oxide,CTD,1.29E-04,1.00E+00,9.82E-03,1.05E-01,10,188,"CLK4,TUBB2B,ADM,DUSP4,PRMT6,EGR1,EGR2,SERPINB1,RAB15,WDFY3" Drug,CID000019390,AC1L2E0P,Stitch,1.34E-04,1.00E+00,1.02E-02,1.08E-01,13,307,"NAB2,PSMC5,CHGA,NR4A1,TMEFF2,LYVE1,SCG2,TAF1,FHL2,KAT6A,NR4A2,NR4A3,LDLR" Drug,6954_UP,fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.34E-04,1.00E+00,1.02E-02,1.09E-01,10,189,"ETS2,ETV5,ISG20,CITED2,DYRK3,SEMA3F,DUSP4,LDLR,OVGP1,EGR1" Drug,ctd:C023035,"3,4,5,3',4'-pentachlorobiphenyl",CTD,1.35E-04,1.00E+00,1.02E-02,1.09E-01,31,1221,"ACOX1,ISG20,SST,SLC25A25,CITED2,PTPRN,KCNK1,TSPO,ARHGAP29,FGF2,HES1,DNM1,FHL2,TAP1,ZNF367,PMP22,PLSCR4,RAF1,PODXL,PPP1R3B,DUSP6,LBR,ZNF784,LDLR,EDN1,RHO,FADS1,EGR1,AACS,PHYHIPL,MX1" Drug,2539_UP,Leflunomide [75706-12-6]; Up 200; 14.8uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.40E-04,1.00E+00,1.05E-02,1.12E-01,10,190,"SYNDIG1,NR4A1,B4GALT6,LYVE1,DSTYK,SYT5,HTR1B,DUSP4,NR4A2,RHO" Drug,1483_UP,Dicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.40E-04,1.00E+00,1.05E-02,1.12E-01,10,190,"ETS2,ISG20,NR4A1,ARC,FGF2,DNM1,RASA3,NR4A2,NR4A3,EGR1" Drug,961_UP,5253409; Up 200; 17uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.40E-04,1.00E+00,1.05E-02,1.12E-01,10,190,"ETS2,ETV5,IER5,ISG20,ADM,DYRK3,NR4A2,FSD1,RGS2,EGR1" Drug,2629_UP,Bepridil hydrochloride [74764-40-2]; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.40E-04,1.00E+00,1.05E-02,1.12E-01,10,190,"ISG20,ARC,FOSB,DUSP2,NR4A2,NR4A3,LDLR,RGS4,EGR1,SNAP25" Drug,1227_UP,LY 294002; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.46E-04,1.00E+00,1.09E-02,1.16E-01,10,191,"MAPKAPK2,ITPKB,NKTR,C17orf80,PLSCR4,DUSP4,DUSP6,NR4A2,KLHL36,FUT1" Drug,3448_UP,Dienestrol [84-17-3]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.46E-04,1.00E+00,1.09E-02,1.16E-01,10,191,"NAB2,ETS2,ARC,PLAT,SUPT20H,RASA3,ZNF329,RGS2,EGR1,MYBL1" Drug,ctd:D006052,Gold Sodium Thiomalate,CTD,1.52E-04,1.00E+00,1.12E-02,1.19E-01,7,92,"GBP1,ISG20,AMIGO2,LAMB3,NR4A3,RGS4,MX1" Drug,2146_UP,Trimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.53E-04,1.00E+00,1.12E-02,1.19E-01,10,192,"SOX4,CHPF,GPR19,DUSP4,FAM131A,LDLR,OVGP1,EGR1,PDP1,CD59" Drug,3470_UP,Securinine [5610-40-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.53E-04,1.00E+00,1.12E-02,1.19E-01,10,192,"ETS2,U2AF2,TNFRSF10B,INKA2,TMPRSS3,ZNF652,DUSP4,MACF1,PLK4,MYBL1" Drug,1221_UP,Rapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.53E-04,1.00E+00,1.12E-02,1.19E-01,10,192,"MAPKAPK2,DSTYK,TMEM231,C17orf80,AMIGO2,SUPT20H,DUSP4,NR4A2,TGIF1,BBC3" Drug,1153_UP,"Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,1.53E-04,1.00E+00,1.12E-02,1.19E-01,10,192,"SSBP2,ISG20,SP140L,AMIGO2,PMP22,DUSP6,NR4A3,EGR1,CD59,MYBL1" Drug,ctd:D019287,Zinc Sulfate,CTD,1.54E-04,1.00E+00,1.12E-02,1.19E-01,22,739,"PCSK2,NAB2,PSMC5,CHGA,CHGB,BDNF,ADM,PTPRN,SCG2,SYT1,HES1,CNN3,FOSB,NR4A3,RGS4,TXNDC12,FADS1,EGR1,PDP1,SYNGR3,SNAP25,BBC3" Drug,CID000035781,"5,7-dihydroxytryptamine",Stitch,1.56E-04,1.00E+00,1.14E-02,1.21E-01,6,65,"PDYN,CHGA,SST,TAC1,HTR1B,SYNM" Drug,425_UP,staurosporine; Up 200; 0.01uM; MCF7; HG-U133A,Broad Institute CMAP Up,1.59E-04,1.00E+00,1.14E-02,1.21E-01,10,193,"IER5,ISG20,NR4A1,EPM2AIP1,HTR1B,TENT5A,DUSP4,NR4A2,LRIG1,SYNGR3" Drug,3810_DN,(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,1.59E-04,1.00E+00,1.14E-02,1.21E-01,10,193,"NAB2,TBC1D2B,U2AF2,NR4A1,RASA3,DUSP2,EGR1,MICAL2,PATJ,BBC3" Drug,5005_UP,Clorgyline hydrochloride [17780-75-5]; Up 200; 13uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.59E-04,1.00E+00,1.14E-02,1.21E-01,10,193,"ETV5,GBP1,ISG20,NR4A1,ARC,PLAT,SP110,EDN1,EGR1,TLE4" Drug,3608_UP,Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.59E-04,1.00E+00,1.14E-02,1.21E-01,10,193,"ETV5,ISG20,NR4A1,ARC,FGF2,DUSP4,NR4A3,CRHBP,EGR1,SYNGR3" Drug,5602_DN,Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.59E-04,1.00E+00,1.14E-02,1.21E-01,10,193,"MAPKAPK2,ETS2,TNFRSF10B,PXN,FGF2,PLSCR4,RGS2,TRIM3,IFRD1,TLE4" Drug,ctd:D001379,Azathioprine,CTD,1.59E-04,1.00E+00,1.14E-02,1.21E-01,20,639,"CENPF,GBP1,IER5,MCM6,ZNF385B,ISG20,ADM,DTX4,AMIGO2,LAMB3,NR4A3,STMN1,RGS4,RIT1,EGR1,EGR2,SPRY4,RBM24,MX1,MYBL1" Drug,ctd:D003976,Diazinon,CTD,1.60E-04,1.00E+00,1.14E-02,1.22E-01,36,1524,"CENPF,ETS2,MCM6,SYNDIG1,CHGA,CHGB,PFKP,BDNF,CKS2,KCNK1,FGF2,MCRS1,TAC1,ARRDC3,MIEF2,ZNF367,AMIGO2,DYRK2,PMP22,GPI,FLT3LG,HTR1B,ZNF652,MUS81,CCT2,RFX3,RGS2,LDLR,TRIM3,CITED4,NACC2,EGR1,PRKAB2,CEP57,BBC3,PLK4" Drug,4736_DN,Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.66E-04,1.00E+00,1.17E-02,1.24E-01,10,194,"ETV5,U2AF2,TMPRSS3,NKTR,C17orf80,SEMA3F,DUSP4,FAM131A,BBC3,PLK4" Drug,1707_DN,Acetohexamide [968-81-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.66E-04,1.00E+00,1.17E-02,1.24E-01,10,194,"CENPF,NAB2,U2AF2,DNM1,SEMA3F,LAMB3,FAM131A,SP110,TRIM3,PATJ" Drug,1581_DN,Chlorthalidone [77-36-1]; Down 200; 11.8uM; HL60; HG-U133A,Broad Institute CMAP Down,1.66E-04,1.00E+00,1.17E-02,1.24E-01,10,194,"FAM168B,LGR4,NR4A1,TMEM231,DYRK2,CACNB1,ZNF652,EGR1,MARF1,SNAP25" Drug,6835_UP,Clobetasol propionate [25122-46-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.66E-04,1.00E+00,1.17E-02,1.24E-01,10,194,"CENPF,SYT5,SEMA3F,GPR3,CACNB1,DUSP4,KAT6A,NR4A2,FSTL1,FUT1" Drug,CID000006410,tert-butyl hydroperoxide,Stitch,1.67E-04,1.00E+00,1.17E-02,1.24E-01,25,902,"MATN2,ETS2,MCM6,TUBB2B,NR4A1,SST,BDNF,CEP170,ADM,SYT1,NKTR,FHL2,COPS6,AMIGO2,PLSCR4,DOCK2,DUSP6,APEX1,LBR,RGS2,LDLR,EGR1,PDP1,CEP57,MX1" Drug,5743_UP,Cycloheximide [66-81-9]; Up 200; 14.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.67E-04,1.00E+00,1.17E-02,1.24E-01,9,158,"SOX4,SPRY2,WDR33,CLK4,ETS2,BDNF,CITED2,ADM,EDN1" Drug,ctd:C030973,cupric oxide,CTD,1.69E-04,1.00E+00,1.18E-02,1.26E-01,18,543,"MCM6,TUBB2B,NCL,ISG20,NR4A1,TUBB6,DST,ARC,HES1,CNN3,PODXL,PPP1R3B,FOSB,NR4A3,RIT1,EGR1,MARF1,MYBL1" Drug,CID000003413,forskolin from Coleus forskohlii,Stitch,1.72E-04,1.00E+00,1.18E-02,1.26E-01,27,1013,"MSC,PDYN,NAB2,TUBB2B,CHGA,CHGB,NR4A1,SST,BDNF,ADM,TUBB6,SCG2,FGF2,TAC1,PLAT,GPI,RAF1,HTR1B,DUSP2,NR4A2,NR4A3,RGS2,RGS4,S1PR3,CRHBP,EDN1,EGR1" Drug,ctd:D015632,"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine",CTD,1.72E-04,1.00E+00,1.18E-02,1.26E-01,13,315,"ATP6V0C,PDYN,PSMC5,BDNF,COX5A,RASA3,FOSB,NR4A2,APEX1,STMN1,RGS2,EGR1,SYNGR3" Drug,5241_UP,haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.73E-04,1.00E+00,1.18E-02,1.26E-01,10,195,"CENPF,ISG20,PXN,ARC,SEMA3F,MAP4K5,PATJ,BBC3,PLK4,MX1" Drug,3757_UP,Fluocinonide [356-12-7]; Up 200; 8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.73E-04,1.00E+00,1.18E-02,1.26E-01,10,195,"PCSK1,NAB2,TMPRSS3,LBH,PLAT,CACNB1,NPTX2,RASA3,LRIG1,BBC3" Drug,1539_UP,Haloperidol [52-86-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.73E-04,1.00E+00,1.18E-02,1.26E-01,10,195,"SERPINF1,ISG20,C1QL1,SCG2,DYRK3,VPS39,KAT6A,SP110,TRIM3,OVGP1" Drug,3034_DN,Capsaicin [404-86-4]; Down 200; 13uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,1.73E-04,1.00E+00,1.18E-02,1.26E-01,10,195,"SOX4,ACOX1,GBP1,SSBP2,B4GALT6,GPR3,EGR1,WDFY3,BBC3,PLK4" Drug,7327_DN,Etofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.73E-04,1.00E+00,1.18E-02,1.26E-01,10,195,"CENPF,MAPKAPK2,ACOX1,DSTYK,PXN,TMEM231,ZNF329,LAMB3,PRKAB2,PATJ" Drug,ctd:D004390,Chlorpyrifos,CTD,1.77E-04,1.00E+00,1.20E-02,1.28E-01,26,960,"PCSK2,RNF112,PDYN,CHGA,CHGB,NR4A1,SST,BDNF,CIAPIN1,PXN,ARC,FGF2,MCRS1,TAC1,TAF1,NPTX2,HTR1B,DUSP2,PPAT,RGS2,CRHBP,EGR2,SPRY4,PRKAB2,NPAS4,MX1" Drug,ctd:C029497,"2,3-bis(3'-hydroxybenzyl)butyrolactone",CTD,1.80E-04,1.00E+00,1.20E-02,1.28E-01,26,961,"SOX4,CENPF,IER5,MCM6,SSBP2,CITED2,CKS2,TMPRSS3,HES1,ZNF160,ZNF367,NR4A2,STMN1,PPAT,RGS2,LDLR,S1PR3,TGIF1,LRIG1,EGR1,SYNGR3,MYLIP,HELZ2,CD59,CEP57,PLK4" Drug,7025_UP,Clorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"GJD2,B4GALT6,ITPKB,SYT5,PLAT,DYRK3,SEMA3F,CACNB1,DUSP2,LRIG1" Drug,2072_UP,Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"SOX4,NR4A1,CITED2,DSTYK,NKTR,SP110,EGR1,TLE4,BBC3,MX1" Drug,3789_DN,(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"NAB2,TNFRSF10B,NKTR,GPR19,KAT6A,NR4A2,RGS4,KLHL36,WDFY3,PATJ" Drug,1687_UP,Hydroflumethiazide [135-09-1]; Up 200; 12uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"GBP1,ISG20,NR4A1,ADM,ARC,SEMA3F,SUPT20H,GPR19,DUSP6,PDP1" Drug,7173_UP,Ungerine nitrate; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"TNFRSF10B,CITED2,DSTYK,TMPRSS3,PXN,ARC,DYRK3,RASA3,NR4A2,PATJ" Drug,4673_UP,Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"TBC1D2B,ETV5,LYVE1,PLPPR4,SEMA3F,SUPT20H,NR4A2,TRIM3,TLE4,PLK4" Drug,5249_DN,Phthalylsulfathiazole [85-73-4]; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"ZNF136,ITPKB,TAF1,C17orf80,DYRK3,ZNF652,ZNF329,POT1,WDFY3,PLK4" Drug,6000_UP,Moricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.81E-04,1.00E+00,1.20E-02,1.28E-01,10,196,"GP6,WDR33,ETV5,DSTYK,C17orf80,CACNB1,RASA3,DUSP2,EDN1,TRIM3" Drug,3026_DN,Ioversol [87771-40-2]; Down 200; 5uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"SOX4,CENPF,SSBP2,CHPF,RASA3,DUSP6,KLHL36,CD59,PLK4,MYBL1" Drug,2075_UP,Pindolol [13523-86-9]; Up 200; 16.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"SOX4,NAB2,NR4A1,ITPKB,ANOS1,SP140L,DYRK3,NR4A2,FAM131A,WDFY3" Drug,1499_DN,Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"CNKSR1,RNF43,SYT1,TMEM231,DYRK3,VPS39,DUSP2,DUSP4,FUT1,MPZL2" Drug,7064_DN,0198306-0000 [212631-61-3]; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"IER5,TNFRSF10B,DUSP4,CHSY1,LBR,EGR1,MICAL2,PDP1,TLE4,MPZL2" Drug,4177_DN,Gelsemine [509-15-9]; Down 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"SERPINF1,NR4A1,INKA2,LYVE1,ARC,DYRK3,SEMA3F,DUSP4,FAM131A,EGR1" Drug,6017_DN,Isotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"MAPKAPK2,SSBP2,NR4A1,ITPKB,KCNF1,DYRK3,ZNF329,FAM131A,SYNGR3,FUT1" Drug,3717_UP,Heliotrine [303-33-3]; Up 200; 12.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"INKA2,ARC,CACNB1,GPR19,KAT6A,RGS4,EGR1,TLE4,BBC3,PLK4" Drug,3478_DN,Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.88E-04,1.00E+00,1.22E-02,1.30E-01,10,197,"WDR33,MAPKAPK2,SERPINF1,ETS2,ISG20,ADM,DTX4,STRN4,MCRS1,SEMA3F" Drug,ctd:D011239,Prednisolone,CTD,1.92E-04,1.00E+00,1.24E-02,1.32E-01,9,161,"GBP1,ISG20,SCG2,ARRDC3,AMIGO2,LAMB3,NR4A3,RGS4,MX1" Drug,1140_UP,MG-132; Up 200; 21uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.92E-04,1.00E+00,1.24E-02,1.32E-01,9,161,"WDR33,ETS2,IER5,TNFRSF10B,GCC1,LDLR,IFRD1,EGR1,FUT1" Drug,ctd:C042720,mercuric bromide,CTD,1.93E-04,1.00E+00,1.24E-02,1.33E-01,28,1076,"A1BG,PCSK1,MIF4GD,ZNF385B,PFKP,SST,BDNF,ADM,LYVE1,DSTYK,KCNK1,NAV1,TAC1,DCLK2,TMEM231,AMIGO2,VWF,FEZF2,DUSP2,KAT6A,EDN1,IFRD1,SYNGR3,SPRY4,SERPINB1,MPZL2,PATJ,ANKRD33B" Drug,3441_DN,Sulfadimethoxine [122-11-2]; Down 200; 12.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.96E-04,1.00E+00,1.25E-02,1.33E-01,10,198,"TBC1D2B,ETS2,TNFRSF10B,ITPKB,KCNF1,DNM1,DUSP4,TRIM3,EGR1,PDP1" Drug,7509_UP,16-phenyl tetranor Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.96E-04,1.00E+00,1.25E-02,1.33E-01,10,198,"ISG20,TNFRSF10B,BDNF,INKA2,SMG6,CACNB1,NR4A2,CORO1A,PATJ,MX1" Drug,1940_DN,Dehydrocholic acid [81-23-2]; Down 200; 9.6uM; PC3; HG-U133A,Broad Institute CMAP Down,1.96E-04,1.00E+00,1.25E-02,1.33E-01,10,198,"CNKSR1,ZFAND5,SP140L,STRN4,GCC1,NKTR,MED17,POT1,MACF1,WDFY3" Drug,7442_DN,Acemetacin [53164-05-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,1.96E-04,1.00E+00,1.25E-02,1.33E-01,10,198,"TNFRSF10B,SP140L,PXN,SUPT20H,GPR19,VPS39,KAT6A,FAM131A,LRIG1,PATJ" Drug,3509_UP,Levocabastine hydrochloride [79547-78-7]; Up 200; 8.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.96E-04,1.00E+00,1.25E-02,1.33E-01,10,198,"ETV5,GBP1,NR4A1,LYVE1,CACNB1,DUSP6,FAM131A,RGS2,TRIM3,HCRTR2" Drug,ctd:C006703,benzo(b)fluoranthene,CTD,1.99E-04,1.00E+00,1.26E-02,1.34E-01,36,1541,"SOX4,MYO1G,SERPINF1,NAB2,IER5,MCM6,TUBB2B,TNFRSF10B,INKA2,TMEFF2,CITED2,ADM,TUBB6,LYVE1,MDN1,TMEM178A,DTX4,SYT1,PLAT,NKTR,TAF1,FHL2,TAP1,FOXF1,ZNF367,PMP22,VWF,VPS39,PODXL,PPP1R3B,STMN1,EGR1,MICAL2,NIPAL1,SERPINB1,MPZL2" Drug,1527_UP,Moroxidine hydrochloride [3160-91-6]; Up 200; 19.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"SPRY2,SERPINF1,ISG20,NR4A1,INKA2,DYRK3,DUSP2,KAT6A,LAMB3,PDP1" Drug,4337_UP,Proglumide [6620-60-6]; Up 200; 12uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"GP6,TBC1D2B,CACNB1,NPTX2,DUSP2,RGS4,TRIM3,OVGP1,EGR4,FUT1" Drug,6006_DN,Nifedipine [21829-25-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"SPRY2,MAPKAPK2,NR4A1,ITPKB,PMP22,GPR19,PODXL,NR4A2,FAM131A,MAP4K5" Drug,2820_UP,Tadjakonine [11087-94-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"ZNF154,NAB2,ETV5,NR4A1,FGF2,DYRK3,NR4A2,LAMB3,TRIM3,RHO" Drug,6830_DN,Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"MAPKAPK2,ETS2,DSTYK,TMPRSS3,NKTR,DNM1,SEMA3F,SYNM,NR4A2,SP110" Drug,CID000000836,"3,4-dihydroxyphenylalanine",Stitch,2.04E-04,1.00E+00,1.27E-02,1.36E-01,10,199,"PDYN,TUBB2B,NR4A1,SST,BDNF,TUBB6,HTR1B,FOSB,NR4A2,EGR1" Drug,ctd:D016685,Mitomycin,CTD,2.08E-04,1.00E+00,1.29E-02,1.38E-01,15,410,"CENPF,MATN2,INKA2,CKS2,FGF2,PMP22,TENT5A,DUSP4,APEX1,IFRD1,EGR1,MYLIP,CD59,CEP57,MX1" Drug,2885_DN,Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.11E-04,1.00E+00,1.29E-02,1.38E-01,9,163,"SOX4,LGR4,CITED2,HES1,NKTR,GPR19,TENT5A,LRIG1,MPZL2" Drug,ctd:D015647,"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine",CTD,2.11E-04,1.00E+00,1.29E-02,1.38E-01,9,163,"PDYN,ARC,SYT1,TAC1,CNN3,CCT2,CORO1A,EGR1,SNAP25" Drug,CID000151956,Arginylarginine,Stitch,2.11E-04,1.00E+00,1.29E-02,1.38E-01,9,163,"PCSK1,PCSK2,PDYN,CHGB,DPP8,SST,SCG2,NPTX2,EDN1" Drug,2145_UP,Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.11E-04,1.00E+00,1.29E-02,1.38E-01,9,163,"ETS2,ISG20,BDNF,FOSB,DUSP2,DUSP4,NR4A2,NR4A3,RGS2" Drug,1498_UP,Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.11E-04,1.00E+00,1.29E-02,1.38E-01,9,163,"SOX4,ETS2,ETV5,TNFRSF10B,DUSP4,LDLR,TGIF1,IFRD1,EGR1" Drug,ctd:C513428,pyrachlostrobin,CTD,2.12E-04,1.00E+00,1.30E-02,1.39E-01,23,809,"CENPF,SERPINF1,TNFRSF10B,INKA2,ADM,TUBB6,BBX,METRN,TMEM178A,TSPO,HS3ST2,TAP1,CNN3,PMP22,SHROOM3,PPP1R3B,FOSB,RBMS2,SHC1,S1PR3,CRHBP,FSTL1,NACC2" Drug,6992_DN,rosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,2.13E-04,1.00E+00,1.30E-02,1.39E-01,10,200,"NAB2,ETS2,PXN,SYNM,RBMS2,NR4A2,MAP4K5,TLE4,MPZL2,PLK4" Drug,ctd:D016713,Ritanserin,CTD,2.14E-04,1.00E+00,1.30E-02,1.39E-01,3,10,"PDYN,BDNF,HTR1B" Drug,ctd:C523799,MRK 003,CTD,2.19E-04,1.00E+00,1.33E-02,1.42E-01,22,758,"SERPINF1,NAB2,HLA-E,IER5,MCM6,CEP170,TUBB6,BASP1,NAV1,MS4A8,PLAT,HES1,CNN3,PMP22,PPP1R3B,RGS4,LRIG1,NIPAL1,SNAP25,PATJ,BBC3,ANKRD33B" Drug,CID000000892,myo-inositol,Stitch,2.20E-04,1.00E+00,1.33E-02,1.42E-01,23,811,"CHGB,ITPKB,ADM,COX5A,TAC1,ARRDC3,DNM1,RAF1,CACNB1,SHROOM3,HTR1B,RASA3,RBMS2,DUSP2,SHC1,RGS2,RGS4,S1PR3,EDN1,RHO,PDP1,MT-ND1,CD59" Drug,4985_UP,Lasalocid sodium salt [25999-20-6]; Up 200; 6.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.20E-04,1.00E+00,1.33E-02,1.42E-01,9,164,"ETV5,GBP1,ISG20,CITED2,ADM,DUSP4,DUSP6,LDLR,EGR1" Drug,2920_UP,Proscillaridin A [466-06-8]; Up 200; 7.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,2.20E-04,1.00E+00,1.33E-02,1.42E-01,9,164,"NR4A1,FOSB,NR4A2,NR4A3,LDLR,RIT1,OVGP1,EGR1,KLHL36" Drug,ctd:C010313,pseudocumene,CTD,2.21E-04,1.00E+00,1.33E-02,1.42E-01,10,201,"PSMC5,NR4A1,ARC,NR4A2,APEX1,NR4A3,RGS2,EGR4,MARF1,FUT1" Drug,486_UP,calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A,Broad Institute CMAP Up,2.31E-04,1.00E+00,1.38E-02,1.47E-01,9,165,"NAB2,ZFAND5,NR4A1,HES1,GPR3,TENT5A,DUSP4,LDLR,EGR1" Drug,4444_UP,SAHA; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.31E-04,1.00E+00,1.38E-02,1.47E-01,9,165,"SSBP2,NR4A1,ADM,PLPPR4,SYT1,RGS4,CORO1A,SYNGR3,MYBL1" Drug,ctd:D003375,Coumestrol,CTD,2.32E-04,1.00E+00,1.39E-02,1.48E-01,40,1796,"SOX4,CENPF,IER5,MCM6,SSBP2,ZNF385B,CITED2,CKS2,STRADA,TMPRSS3,HES1,ARRDC3,FHL2,ZNF160,ZNF367,PMP22,SHROOM3,KAT6A,NR4A2,STMN1,LBR,PPAT,RGS2,LDLR,S1PR3,EDN1,TGIF1,FADS1,LRIG1,EGR1,PDP1,SYNGR3,MYLIP,HELZ2,CD59,SERPINB1,RBM24,PATJ,CEP57,PLK4" Drug,ctd:D004237,Diuron,CTD,2.33E-04,1.00E+00,1.39E-02,1.48E-01,39,1735,"SOX4,SYNPO2,WDR33,MATN2,ACOX1,SERPINF1,NAB2,ETS2,LGR4,ISG20,MCCC2,B4GALT6,CITED2,LYVE1,COX5A,STRADA,HYAL3,PLAT,HES1,ARRDC3,FHL2,CHPF,CNN3,MIEF2,PMP22,SYNM,TENT5A,KAT6A,LAMB3,RGS2,ARL4D,FSTL1,EGR2,MICAL2,PDP1,MT-ND1,CD59,SERPINB1,RAB15" Drug,CID000002232,1dwc,Stitch,2.33E-04,1.00E+00,1.39E-02,1.48E-01,5,45,"GP6,PLAT,VWF,DUSP2,PLK4" Drug,ctd:C016599,mono-(2-ethylhexyl)phthalate,CTD,2.39E-04,1.00E+00,1.42E-02,1.51E-01,20,659,"ACOX1,LGR4,NR4A1,TUBB6,DST,TSPO,LBH,TAF1,ARRDC3,DUSP6,NR4A2,NR4A3,CRHBP,EDN1,LRIG1,EGR1,EGR4,MT-ND1,SPRY4,BBC3" Drug,ctd:C424127,SL 327,CTD,2.41E-04,1.00E+00,1.42E-02,1.52E-01,4,25,"PDYN,BDNF,FOSB,EGR1" Drug,ctd:C031180,chrysene,CTD,2.50E-04,1.00E+00,1.47E-02,1.57E-01,24,872,"SOX4,MYO1G,CLK4,IER5,TNFRSF10B,RNF43,INKA2,TMEFF2,CITED2,ADM,LYVE1,MDN1,UBR5,DTX4,PLAT,NKTR,TAF1,TAP1,FOXF1,ZNF367,PMP22,VPS39,SERPINB1,ZNF664" Drug,5212_UP,prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.52E-04,1.00E+00,1.49E-02,1.58E-01,9,167,"ETS2,ETV5,IER5,ISG20,DUSP4,NR4A2,TRIM3,EGR1,BBC3" Drug,CID006439899,agelasine B,Stitch,2.59E-04,1.00E+00,1.52E-02,1.62E-01,5,46,"CHGA,RAF1,DUSP2,SHC1,EGR1" Drug,CID000000681,dopamine,Stitch,2.60E-04,1.00E+00,1.52E-02,1.62E-01,21,715,"GJD2,PDYN,NCL,NR4A1,SST,BDNF,COX5A,SCG2,TSPO,SYT1,TAC1,HTR1B,FOSB,NR4A2,NR4A3,RGS2,RGS4,RHO,EGR1,MT-ND1,SNAP25" Drug,4018_UP,Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,2.64E-04,1.00E+00,1.54E-02,1.64E-01,9,168,"DSTYK,FGF2,AMIGO2,DYRK3,LDLR,RGS4,TGIF1,EGR1,PDP1" Drug,2801_UP,Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.64E-04,1.00E+00,1.54E-02,1.64E-01,9,168,"WDR33,CLK4,ADM,HES1,DUSP4,DUSP6,NR4A3,EGR1,SYNGR3" Drug,7441_UP,Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,2.76E-04,1.00E+00,1.59E-02,1.70E-01,9,169,"NAB2,NR4A1,TMPRSS3,DUSP4,NR4A2,NR4A3,LDLR,EGR1,MARF1" Drug,4632_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,2.76E-04,1.00E+00,1.59E-02,1.70E-01,9,169,"SSBP2,PLPPR4,SYT1,DYRK3,PLSCR4,NR4A2,RGS4,CORO1A,MYBL1" Drug,1793_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,2.76E-04,1.00E+00,1.59E-02,1.70E-01,9,169,"CITED2,SYT1,DYRK3,PMP22,DUSP6,NR4A2,RGS4,CORO1A,MYBL1" Drug,ctd:C010063,carbonyl sulfide,CTD,2.79E-04,1.00E+00,1.61E-02,1.71E-01,8,134,"NR4A1,TUBB6,TSPO,HES1,PODXL,NR4A3,EGR1,EGR4" Drug,CID000443590,telomestatin,Stitch,2.82E-04,1.00E+00,1.62E-02,1.73E-01,4,26,"TSPO,SMG6,POT1,EGR1" Drug,ctd:D008942,Mitoxantrone,CTD,2.83E-04,1.00E+00,1.63E-02,1.73E-01,11,247,"LGR4,ISG20,BBX,LBH,PLAT,TAP1,DYRK2,DUSP4,NR4A2,RGS2,EGR1" Drug,CID000007991,valerate,Stitch,2.87E-04,1.00E+00,1.65E-02,1.75E-01,7,102,"NR4A1,FGF2,VWF,NR4A2,NR4A3,LBR,EGR1" Drug,CID000008078,cyclohexane,Stitch,2.88E-04,1.00E+00,1.65E-02,1.75E-01,9,170,"TNFRSF10B,PFKP,SYT1,GPI,NR4A2,LDLR,IFRD1,EGR1,BBC3" Drug,CID000086384,regalis,Stitch,2.91E-04,1.00E+00,1.66E-02,1.77E-01,3,11,"FEZF2,LBR,MT-ND1" Drug,CID000132605,D-Rgdw,Stitch,2.91E-04,1.00E+00,1.66E-02,1.77E-01,3,11,"GP6,PLAT,VWF" Drug,ctd:C502851,quinocetone,CTD,2.93E-04,1.00E+00,1.67E-02,1.77E-01,11,248,"PSMC5,NR4A1,PFKP,BDNF,KCNE4,LBH,TAC1,RASA3,NR4A2,STMN1,SPRY4" Drug,ctd:D012906,Smoke,CTD,2.96E-04,1.00E+00,1.68E-02,1.79E-01,25,937,"SOX4,MATN2,ETV5,ZNF385B,NR4A1,B4GALT6,BDNF,DST,METRN,TMPRSS3,KCNK1,TSPO,FGF2,SYT1,PLAT,DYRK3,DOCK2,DUSP6,S1PR3,OVGP1,EGR1,SPRY4,FUT1,PATJ,MX1" Drug,4237_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,3.01E-04,1.00E+00,1.69E-02,1.81E-01,9,171,"SSBP2,NR4A1,ANOS1,PLPPR4,SYT1,DYRK3,PLSCR4,RGS4,CORO1A" Drug,1598_UP,Colchicine [64-86-8]; Up 200; 10uM; HL60; HG-U133A,Broad Institute CMAP Up,3.01E-04,1.00E+00,1.69E-02,1.81E-01,9,171,"ISG20,NR4A1,DUSP4,NR4A2,NR4A3,RIT1,IFRD1,MICAL2,MARF1" Drug,ctd:C063509,N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide,CTD,3.14E-04,1.00E+00,1.75E-02,1.87E-01,9,172,"NR4A1,BDNF,ADM,FGF2,TAC1,NR4A2,EDN1,EGR1,SNAP25" Drug,1916_UP,Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HG-U133A,Broad Institute CMAP Up,3.14E-04,1.00E+00,1.75E-02,1.87E-01,9,172,"ETS2,TNFRSF10B,DYRK3,NR4A2,LDLR,RGS4,EDN1,TGIF1,IFRD1" Drug,1017_UP,fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,3.14E-04,1.00E+00,1.75E-02,1.87E-01,9,172,"ETV5,ISG20,DSTYK,CHPF,DUSP4,LDLR,FADS1,LRIG1,EGR1" Drug,5903_DN,"trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Down,3.14E-04,1.00E+00,1.75E-02,1.87E-01,9,172,"NAB2,ITPKB,KCNK1,TAF1,RASA3,DUSP4,TGIF1,WDFY3,PATJ" Drug,CID003025353,L024104,Stitch,3.17E-04,1.00E+00,1.76E-02,1.88E-01,5,48,"PDYN,SST,TAC1,DNM1,FOSB" Drug,ctd:D003975,Diazepam,CTD,3.19E-04,1.00E+00,1.77E-02,1.89E-01,6,74,"PDYN,BDNF,TSPO,FGF2,TAC1,EGR1" Drug,ctd:C011272,perfosfamide,CTD,3.19E-04,1.00E+00,1.77E-02,1.89E-01,6,74,"HES1,TAP1,FOXF1,APEX1,EGR1,BBC3" Drug,CID003413300,c7E3,Stitch,3.27E-04,1.00E+00,1.80E-02,1.92E-01,4,27,"FGF2,PLAT,VWF,DUSP2" Drug,5612_UP,Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.28E-04,1.00E+00,1.80E-02,1.92E-01,9,173,"CLK4,NR4A1,ADM,HES1,DUSP6,ZNF329,NR4A3,EGR1,FUT1" Drug,7077_UP,"trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,3.28E-04,1.00E+00,1.80E-02,1.92E-01,9,173,"NR4A1,CITED2,ADM,PLPPR4,SYT1,DYRK3,PLSCR4,RGS4,CORO1A" Drug,1232_UP,troglitazone; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.28E-04,1.00E+00,1.80E-02,1.92E-01,9,173,"CITED2,ADM,DTX4,FGF2,PLSCR4,DUSP2,RGS4,IFRD1,BBC3" Drug,4544_UP,Beta-Escin [11072-93-8]; Up 200; 3.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.42E-04,1.00E+00,1.87E-02,1.99E-01,9,174,"ETS2,NR4A1,ADM,ARC,FOSB,NR4A2,RGS4,EGR1,TLE4" Drug,CID000088656,Trp-Trp,Stitch,3.49E-04,1.00E+00,1.91E-02,2.03E-01,5,49,"CHGA,CHGB,SCG2,SMURF2,LDLR" Drug,CID000126332,glicentin,Stitch,3.49E-04,1.00E+00,1.91E-02,2.03E-01,5,49,"PCSK1,PCSK2,CHGA,SST,SCG2" Drug,1231_UP,15d-PGJ2; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,3.56E-04,1.00E+00,1.93E-02,2.06E-01,9,175,"MAPKAPK2,IER5,ZFAND5,ADM,SCG2,AMIGO2,DUSP2,LDLR,IFRD1" Drug,7073_UP,"trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,3.56E-04,1.00E+00,1.93E-02,2.06E-01,9,175,"SSBP2,TNFRSF10B,NR4A1,ANOS1,PLPPR4,SYT1,DYRK3,RGS4,CORO1A" Drug,CID000327967,AC1L71LQ,Stitch,3.57E-04,1.00E+00,1.93E-02,2.06E-01,8,139,"PCSK1,PCSK2,NR4A1,SYT1,TAF1,LBR,IFRD1,EGR1" Drug,ctd:C008261,lead acetate,CTD,3.63E-04,1.00E+00,1.96E-02,2.09E-01,40,1836,"SOX4,SPRY2,MAPKAPK2,PDYN,NR4A1,STX1B,BDNF,TUBB6,LYVE1,PTPRN,CIAPIN1,ARC,FGF2,LBH,SYT1,PLAT,ZNF160,RAF1,SHROOM3,HTR1B,KAT6A,APEX1,NR4A3,SP110,LDLR,RIT1,IFRD1,LRIG1,EGR1,EGR2,MAP4K5,CD59,MACF1,ELF2,SNAP25,RBM24,ANKRD33B,PLK4,NPAS4,MYBL1" Drug,5588_UP,geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.72E-04,1.00E+00,2.00E-02,2.13E-01,9,176,"SERPINF1,SYNDIG1,ISG20,ADM,CACNB1,ZNF329,RGS2,LDLR,FSTL1" Drug,ctd:D019821,Simvastatin,CTD,3.82E-04,1.00E+00,2.05E-02,2.18E-01,18,581,"HLA-E,BDNF,ARHGAP29,PXN,FGF2,LBH,PLAT,RAF1,VWF,FOSB,NR4A3,RGS2,LDLR,S1PR3,EDN1,CORO1A,EGR1,BBC3" Drug,CID000127614,CIPE,Stitch,3.85E-04,1.00E+00,2.05E-02,2.18E-01,3,12,"COX5A,TSPO,FGF2" Drug,ctd:C529311,CTAP octapeptide,CTD,3.85E-04,1.00E+00,2.05E-02,2.18E-01,3,12,"PDYN,ARC,EGR1" Drug,CID005462310,CTK2H7378,Stitch,3.85E-04,1.00E+00,2.05E-02,2.18E-01,3,12,"DUSP2,APEX1,UTP4" Drug,7555_UP,"trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,3.87E-04,1.00E+00,2.05E-02,2.18E-01,9,177,"MAPKAPK2,TNFRSF10B,CITED2,ADM,SYT1,DYRK3,RGS4,CORO1A,MYBL1" Drug,2690_UP,thioridazine hydrochloride; Up 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.87E-04,1.00E+00,2.05E-02,2.18E-01,9,177,"ISG20,NR4A1,SYT5,DUSP4,NR4A2,NR4A3,RGS2,RIT1,EGR4" Drug,3312_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,3.87E-04,1.00E+00,2.05E-02,2.18E-01,9,177,"ETV5,SSBP2,ADM,DYRK3,PMP22,RGS2,ARL4D,CORO1A,EGR1" Drug,3060_UP,Digoxigenin [1672-46-4]; Up 200; 10.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,3.87E-04,1.00E+00,2.05E-02,2.18E-01,9,177,"WDR33,CLK4,IER5,FOSB,NR4A2,NR4A3,RGS2,OVGP1,EGR1" Drug,4164_UP,Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,3.87E-04,1.00E+00,2.05E-02,2.18E-01,9,177,"GBP1,ISG20,NR4A1,FGF2,HTR1B,DUSP4,NR4A2,NR4A3,EGR1" Drug,CID000068615,AC1L2A3V,Stitch,3.96E-04,1.00E+00,2.09E-02,2.23E-01,6,77,"PCSK2,PDYN,SST,TAC1,GPI,PDP1" Drug,2213_UP,Ivermectin [70288-86-7]; Up 200; 4.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.04E-04,1.00E+00,2.11E-02,2.25E-01,9,178,"ETV5,ISG20,NR4A1,DUSP4,DUSP6,TGIF1,IFRD1,EGR4,MX1" Drug,5940_UP,"trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,4.04E-04,1.00E+00,2.11E-02,2.25E-01,9,178,"SSBP2,NR4A1,CITED2,PLPPR4,ARC,SYT1,PLSCR4,RGS4,CORO1A" Drug,1736_DN,Parthenolide [20554-84-1]; Down 200; 16.2uM; HL60; HG-U133A,Broad Institute CMAP Down,4.04E-04,1.00E+00,2.11E-02,2.25E-01,9,178,"SOX4,CITED2,NKTR,DYRK2,APEX1,SP110,RGS2,MYLIP,WDFY3" Drug,CID000024841,iodide,Stitch,4.07E-04,1.00E+00,2.13E-02,2.26E-01,17,534,"SST,BDNF,ADM,TSPO,FGF2,TAC1,PLAT,TAP1,GPI,VWF,PODXL,DUSP2,NR4A2,LDLR,EDN1,RIT1,MPZL2" Drug,CID000001257,LY 171555,Stitch,4.12E-04,1.00E+00,2.15E-02,2.29E-01,8,142,"PDYN,SST,BDNF,HTR1B,NR4A2,RGS2,RHO,EGR1" Drug,ctd:D007545,Isoproterenol,CTD,4.17E-04,1.00E+00,2.17E-02,2.31E-01,26,1015,"CNKSR1,NAB2,MCCC2,NR4A1,ITPKB,CITED2,ADM,TUBB6,LYVE1,METRN,DTX4,LBH,TAC1,PLAT,HES1,ARRDC3,SMURF2,VWF,FOSB,DUSP4,APEX1,EDN1,IFRD1,CITED4,EGR1,MYLIP" Drug,4085_UP,Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.20E-04,1.00E+00,2.17E-02,2.31E-01,9,179,"NAB2,LYVE1,KCNK1,ARC,CACNB1,FOSB,NR4A2,RGS4,EGR1" Drug,4456_UP,troglitazone; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.20E-04,1.00E+00,2.17E-02,2.31E-01,9,179,"SYNDIG1,CITED2,ADM,DTX4,ARC,AMIGO2,DUSP2,RGS4,EGR1" Drug,4184_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,4.20E-04,1.00E+00,2.17E-02,2.31E-01,9,179,"ANOS1,PLPPR4,SYT1,NR4A2,NR4A3,RGS4,CORO1A,SYNGR3,BBC3" Drug,4554_DN,Withaferin A [5119-48-2]; Down 200; 1uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,4.20E-04,1.00E+00,2.17E-02,2.31E-01,9,179,"SOX4,CNKSR1,C1QL1,PLPPR4,HES1,SEMA3F,SUPT20H,SERPINB1,FUT1" Drug,CID000006569,methyl ethyl ketone,Stitch,4.31E-04,1.00E+00,2.22E-02,2.36E-01,18,587,"SPRY2,MAPKAPK2,BDNF,FGF2,SYT1,PLAT,DYRK2,RAF1,VWF,TNIP2,DUSP2,DUSP4,DUSP6,SHC1,EDN1,RIT1,EGR1,SPRY4" Drug,7535_UP,irinotecan HCl; Up 200; 100uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.38E-04,1.00E+00,2.25E-02,2.40E-01,9,180,"ETS2,IER5,CITED2,ADM,DYRK3,GPR3,TENT5A,NR4A2,SYNGR3" Drug,1755_DN,Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A,Broad Institute CMAP Down,4.56E-04,1.00E+00,2.33E-02,2.48E-01,9,181,"PFKP,ADM,MCRS1,CHSY1,LBR,LDLR,EGR1,MYLIP,MACF1" Drug,1236_UP,LY 294002; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.56E-04,1.00E+00,2.33E-02,2.48E-01,9,181,"METRN,DSTYK,NKTR,PMP22,PLSCR4,DUSP6,NR4A2,EGR4,KLHL36" Drug,CID000075194,tipps,Stitch,4.58E-04,1.00E+00,2.33E-02,2.48E-01,2,3,"SST,PLAT" Drug,CID005287874,AC1NRAGZ,Stitch,4.58E-04,1.00E+00,2.33E-02,2.48E-01,2,3,"NCL,SUPT20H" Drug,CID005311379,ODN-8,Stitch,4.58E-04,1.00E+00,2.33E-02,2.48E-01,2,3,"SST,ADM" Drug,ctd:D008656,Mestranol,CTD,4.62E-04,1.00E+00,2.34E-02,2.49E-01,5,52,"SSBP2,FHL2,DYRK2,MICAL2,MYBL1" Drug,4989_UP,Thioguanosine [85-31-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.74E-04,1.00E+00,2.39E-02,2.54E-01,9,182,"WDR33,TNFRSF10B,NR4A1,LYVE1,FGF2,NR4A2,OVGP1,EGR1,BBC3" Drug,1663_DN,"ICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A",Broad Institute CMAP Down,4.74E-04,1.00E+00,2.39E-02,2.54E-01,9,182,"ISG20,TNFRSF10B,KCNF1,TMPRSS3,DNM1,FHL2,RBMS2,MICAL2,MYBL1" Drug,1231_DN,15d-PGJ2; Down 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,4.74E-04,1.00E+00,2.39E-02,2.54E-01,9,182,"SOX4,CENPF,SSBP2,FGF2,PLAT,NKTR,DUSP4,DUSP6,PDP1" Drug,5017_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,4.74E-04,1.00E+00,2.39E-02,2.54E-01,9,182,"ETV5,ADM,PLAT,DYRK3,SMG6,PLSCR4,RGS2,ARL4D,CORO1A" Drug,CID000000238,laevadosin,Stitch,4.82E-04,1.00E+00,2.42E-02,2.58E-01,39,1800,"GP6,ATP6V0C,MAPKAPK2,CLK4,PSMC5,U2AF2,MCM6,TUBB2B,MCCC2,NR4A1,PFKP,RNF43,ITPKB,TUBB6,ANAPC1,STRADA,FGF2,SYT1,PLAT,DCLK2,TAF1,TAP1,SMURF2,DYRK3,SMG6,DYRK2,RAF1,VWF,SRSF6,SHC1,CCT2,PPAT,EDN1,MAP4K5,PDP1,PRKAB2,AACS,CEP57,PLK4" Drug,7507_UP,daunorubicin HCl; Up 200; 1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,4.94E-04,1.00E+00,2.45E-02,2.61E-01,9,183,"GP6,TNFRSF10B,NR4A1,ADM,ARC,TMEM231,SYNM,TENT5A,TRIM3" Drug,3232_DN,Mitoxantrone dihydrochloride [70476-82-3]; Down 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,4.94E-04,1.00E+00,2.45E-02,2.61E-01,9,183,"ZNF184,ZFAND5,HES1,AMIGO2,SUPT20H,ZNF254,LDLR,TGIF1,IFRD1" Drug,5764_UP,Terbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.94E-04,1.00E+00,2.45E-02,2.61E-01,9,183,"GBP1,ISG20,RNF43,DSTYK,PMP22,CACNB1,NR4A2,RGS4,EGR1" Drug,7088_DN,pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,4.94E-04,1.00E+00,2.45E-02,2.61E-01,9,183,"SOX4,NAB2,ETV5,U2AF2,SSBP2,BDNF,PLAT,SEMA3F,RGS2" Drug,3704_UP,Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,4.94E-04,1.00E+00,2.45E-02,2.61E-01,9,183,"NR4A1,FGF2,SYT5,RASA3,LDLR,TRIM3,TGIF1,PATJ,PLK4" Drug,CID000091769,zolantidine,Stitch,4.96E-04,1.00E+00,2.45E-02,2.62E-01,3,13,"TAC1,HTR1B,SYNM" Drug,CID000012750,delta3-piperidine,Stitch,4.97E-04,1.00E+00,2.45E-02,2.62E-01,4,30,"PDYN,SST,HTR1B,FOSB" Drug,CID000006623,bisphenol A,Stitch,5.04E-04,1.00E+00,2.49E-02,2.65E-01,10,223,"SOX4,ACOX1,ETS2,PSMC5,MCM6,TUBB6,LYVE1,BASP1,CHSY1,PLK4" Drug,CID005288823,heptamolybdate,Stitch,5.08E-04,1.00E+00,2.50E-02,2.66E-01,7,112,"MAPKAPK2,SST,BDNF,RAF1,RASA3,SHC1,MX1" Drug,ctd:C049584,"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine",CTD,5.12E-04,1.00E+00,2.50E-02,2.67E-01,17,545,"CENPF,TBC1D2B,MCM6,TUBB2B,BASP1,KCNK1,STRN4,TAF1,CNN3,RAF1,CCT2,STMN1,EDN1,CORO1A,EGR1,TLE4,SYNGR3" Drug,1765_UP,Ellipticine [519-23-3]; Up 200; 16.2uM; HL60; HG-U133A,Broad Institute CMAP Up,5.14E-04,1.00E+00,2.50E-02,2.67E-01,9,184,"IER5,BBX,AMIGO2,DYRK2,DUSP4,NR4A2,NR4A3,EGR1,MYBL1" Drug,5530_UP,Parthenolide [20554-84-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.14E-04,1.00E+00,2.50E-02,2.67E-01,9,184,"ISG20,TNFRSF10B,ADM,GCC1,ZNF329,LDLR,RIT1,EGR1,WDFY3" Drug,2758_UP,Ellipticine [519-23-3]; Up 200; 16.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.14E-04,1.00E+00,2.50E-02,2.67E-01,9,184,"ADM,ARC,TENT5A,DUSP6,NR4A2,NR4A3,RGS2,OVGP1,EGR1" Drug,5340_UP,Cyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.14E-04,1.00E+00,2.50E-02,2.67E-01,9,184,"SPRY2,ISG20,NR4A1,ADM,ARC,DUSP4,NR4A2,RGS2,EGR1" Drug,ctd:C061133,tamibarotene,CTD,5.15E-04,1.00E+00,2.51E-02,2.67E-01,18,596,"SPRY2,MAPKAPK2,HLA-E,TUBB2B,ISG20,BDNF,MDN1,DST,PTPRN,TAP1,FOSB,PPAT,EDN1,TGIF1,CORO1A,SERPINB1,MACF1,PLK4" Drug,ctd:D052638,Particulate Matter,CTD,5.32E-04,1.00E+00,2.57E-02,2.74E-01,38,1747,"ETS2,ETV5,TUBB2B,ISG20,TNFRSF10B,NR4A1,BDNF,ADM,CKS2,SP140L,BASP1,ANAPC1,TSPO,FGF2,LBH,SYT1,PLAT,VWF,FOSB,TENT5A,DUSP4,DUSP6,ZNF254,NR4A2,CCT2,FSD1,LDLR,EDN1,EVA1C,TGIF1,CNTD1,FSTL1,EGR1,TLE4,CD59,SERPINB1,SNAP25,BBC3" Drug,1114_DN,tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Down,5.34E-04,1.00E+00,2.57E-02,2.74E-01,9,185,"CLK4,MDN1,MED17,SMURF2,AMIGO2,DYRK2,CHSY1,LDLR,NACC2" Drug,7207_UP,Benzethonium chloride [121-54-0]; Up 200; 9uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.34E-04,1.00E+00,2.57E-02,2.74E-01,9,185,"ETV5,ISG20,RNF43,TAF1,DUSP4,NR4A2,ARL4D,EGR1,FUT1" Drug,5364_DN,Anisomycin [22862-76-6]; Down 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,5.34E-04,1.00E+00,2.57E-02,2.74E-01,9,185,"MATN2,LGR4,DSTYK,AMIGO2,PMP22,SUPT20H,ZNF652,APEX1,MARF1" Drug,1956_UP,Perphenazine [58-39-9]; Up 200; 10uM; PC3; HG-U133A,Broad Institute CMAP Up,5.34E-04,1.00E+00,2.57E-02,2.74E-01,9,185,"ETS2,ISG20,KCNK1,DYRK3,PMP22,DUSP6,LDLR,RGS4,TGIF1" Drug,ctd:D008748,Methylcholanthrene,CTD,5.42E-04,1.00E+00,2.60E-02,2.77E-01,26,1033,"SOX4,SPRY2,CENPF,MATN2,ETV5,PSMC5,MCM6,NR4A1,CKS2,BBX,COX5A,ARRDC3,DYRK2,SYNM,RBMS2,DUSP4,DUSP6,APEX1,STMN1,LBR,FSTL1,PRKAB2,CD59,RBM24,PLK4,HCRTR2" Drug,ctd:D008731,Methoxychlor,CTD,5.44E-04,1.00E+00,2.61E-02,2.78E-01,17,548,"SOX4,ACOX1,PDYN,ETV5,NCL,CHGA,STX1B,TUBB6,PTPRN,PXN,FGF2,TAC1,NR4A3,EDN1,EGR2,RAB15,FUT1" Drug,ctd:C101814,perfluoro-n-undecanoic acid,CTD,5.49E-04,1.00E+00,2.62E-02,2.80E-01,14,402,"CHGB,BDNF,TMEFF2,KCNK1,FGF2,AMIGO2,SHROOM3,SYNM,PODXL,TENT5A,EDN1,HELZ2,RBM24,MX1" Drug,3283_DN,Digoxin [20830-75-5]; Down 200; 5.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,5.55E-04,1.00E+00,2.64E-02,2.81E-01,9,186,"ZNF184,BBX,MCRS1,TMEM231,C17orf80,GPR19,IFRD1,MICAL2,WDFY3" Drug,6671_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,5.55E-04,1.00E+00,2.64E-02,2.81E-01,9,186,"SSBP2,RNF43,PLPPR4,SYT1,DYRK3,NR4A2,RGS4,EDN1,CORO1A" Drug,1004_UP,trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,5.55E-04,1.00E+00,2.64E-02,2.81E-01,9,186,"NAB2,ETS2,ISG20,NR4A1,SCG2,DUSP4,DUSP6,LRIG1,EGR1" Drug,953_UP,radicicol; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"CENPF,WDR33,ETS2,ETV5,ISG20,ADM,ZNF329,LAMB3,SP110" Drug,5420_UP,Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"TBC1D2B,ETV5,FOSB,DUSP4,NR4A2,RGS4,TRIM3,EGR1,EGR4" Drug,1242_UP,Rapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"CENPF,ISG20,METRN,FGF2,AMIGO2,PLSCR4,NR4A2,EGR1,BBC3" Drug,6872_DN,"ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Down,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"MAPKAPK2,TNFRSF10B,KCNF1,SCG2,TMPRSS3,PXN,C17orf80,LDLR,LRIG1" Drug,4207_UP,Dimethisoquin hydrochloride [2773-92-4]; Up 200; 13uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"KCNK1,AMIGO2,HTR1B,NR4A2,RGS4,EGR1,TLE4,SYNGR3,BBC3" Drug,5726_UP,Clotrimazole [23593-75-1]; Up 200; 11.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,5.77E-04,1.00E+00,2.71E-02,2.89E-01,9,187,"NAB2,ETS2,ARC,FGF2,AMIGO2,SP110,RGS4,EDN1,EGR1" Drug,ctd:D015058,1-Naphthylisothiocyanate,CTD,5.95E-04,1.00E+00,2.77E-02,2.96E-01,23,871,"SOX4,ACOX1,NAB2,TUBB2B,ISG20,TNFRSF10B,PFKP,TUBB6,TMEM178A,TSPO,FGF2,LBH,PLAT,FHL2,PPP1R3B,DUSP6,APEX1,CHSY1,RGS2,IFRD1,FSTL1,EGR1,EGR4" Drug,6926_UP,17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"ZNF136,WDR33,NR4A1,RNF43,NR4A2,RGS2,RHO,OVGP1,PLK4" Drug,4405_UP,Dicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"ETS2,ARC,SYT5,PLAT,FOSB,DUSP6,NR4A2,TRIM3,EGR1" Drug,4010_UP,Azacytidine-5 [320-67-2]; Up 200; 16.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"ADM,KCNF1,ARC,HES1,FOSB,RGS2,RGS4,EGR1,BBC3" Drug,5019_UP,Dehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"WDR33,GBP1,ISG20,TNFRSF10B,PLAT,FHL2,SP110,EDN1,MYBL1" Drug,7427_UP,Econazole nitrate [24169-02-6]; Up 200; 9uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"SPRY2,ETS2,NR4A1,DUSP6,NR4A2,EGR1,SYNGR3,SNAP25,PLK4" Drug,3291_DN,Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"ZNF184,ZFAND5,MED17,AMIGO2,DYRK2,DUSP4,LDLR,IFRD1,PLK4" Drug,5882_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,6.00E-04,1.00E+00,2.77E-02,2.96E-01,9,188,"SSBP2,NR4A1,CITED2,PLPPR4,SYT1,TMEM231,PLSCR4,RGS4,CORO1A" Drug,ctd:D010269,Paraquat,CTD,6.10E-04,1.00E+00,2.82E-02,3.00E-01,36,1636,"ATP6V0C,PDYN,TMEM198,ETS2,PSMC5,TNFRSF10B,NR4A1,PFKP,SST,STX1B,BDNF,COX5A,FGF2,SYT1,SYT5,TMEM231,MED17,RAF1,HTR1B,SRSF6,SYNM,SHC1,APEX1,STMN1,RGS4,EDN1,RHO,RIT1,PRMT6,FSTL1,EGR1,EGR4,MT-ND1,AACS,MACF1,BBC3" Drug,4464_UP,2-propylpentanoic acid; Up 200; 500uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.23E-04,1.00E+00,2.84E-02,3.02E-01,9,189,"NR4A1,C1QL1,ARC,SYT1,RGS4,EDN1,CORO1A,SYNGR3,BBC3" Drug,2499_UP,Quercetine dihydrate [6151-25-3]; Up 200; 11.8uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,6.23E-04,1.00E+00,2.84E-02,3.02E-01,9,189,"NAB2,ISG20,CACNB1,FOSB,DUSP4,NR4A2,NR4A3,OVGP1,EGR1" Drug,2695_UP,genistein; Up 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,6.23E-04,1.00E+00,2.84E-02,3.02E-01,9,189,"ISG20,LYVE1,ARC,DUSP4,NR4A2,SP110,TRIM3,RHO,EGR1" Drug,611_UP,geldanamycin; Up 200; 1uM; MCF7; HG-U133A,Broad Institute CMAP Up,6.23E-04,1.00E+00,2.84E-02,3.02E-01,9,189,"CHGB,NR4A1,CKS2,DYRK2,SHC1,RGS2,OVGP1,SNAP25,CEP57" Drug,ctd:C015952,"4-iodo-2,5-dimethoxyphenylisopropylamine",CTD,6.25E-04,1.00E+00,2.84E-02,3.02E-01,3,14,"PDYN,BDNF,EGR1" Drug,CID000017516,promecarb,Stitch,6.25E-04,1.00E+00,2.84E-02,3.02E-01,3,14,"ADM,EDN1,RIT1" Drug,CID000101689,pisatin,Stitch,6.25E-04,1.00E+00,2.84E-02,3.02E-01,3,14,"NR4A2,LBR,MAP4K5" Drug,CID000080274,lotrafiban,Stitch,6.25E-04,1.00E+00,2.84E-02,3.02E-01,3,14,"GP6,PLAT,VWF" Drug,CID000119599,Gr 73632,Stitch,6.25E-04,1.00E+00,2.84E-02,3.02E-01,3,14,"TAC1,HTR1B,NR4A2" Drug,ctd:D003520,Cyclophosphamide,CTD,6.37E-04,1.00E+00,2.88E-02,3.07E-01,18,607,"PCSK2,GBP1,IER5,TUBB2B,CHGA,BDNF,CITED2,ADM,METRN,TAC1,TAP1,FLT3LG,DUSP2,APEX1,EDN1,IFRD1,EGR1,EGR2" Drug,CID009549277,K00039,Stitch,6.39E-04,1.00E+00,2.88E-02,3.07E-01,4,32,"MAPKAPK2,SST,FGF2,SNAP25" Drug,CID000057266,eticlopride,Stitch,6.39E-04,1.00E+00,2.88E-02,3.07E-01,4,32,"GJD2,PDYN,HTR1B,EGR1" Drug,6318_DN,Methotrexate [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"CNKSR1,CENPF,ETS2,ETV5,DSTYK,DYRK2,ZNF254,FSD1,LDLR" Drug,2375_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"NR4A1,PXN,AMIGO2,PMP22,DUSP4,SP110,OVGP1,CD59,MYBL1" Drug,6429_UP,F0447-0125; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"CENPF,NR4A1,ADM,C17orf80,NR4A2,LDLR,MAP4K5,FUT1,BBC3" Drug,6274_DN,Rauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"U2AF2,ISG20,PXN,TMEM231,SUPT20H,PODXL,MICAL2,TLE4,MYBL1" Drug,6844_UP,Oxyphenbutazone [129-20-4]; Up 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"SPRY2,ETV5,NR4A1,ADM,STRN4,HS3ST2,KAT6A,TRIM3,MX1" Drug,5786_UP,Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.47E-04,1.00E+00,2.89E-02,3.07E-01,9,190,"SYNDIG1,ARC,AMIGO2,DUSP2,ZNF254,NR4A2,SP110,RGS4,EGR1" Drug,CID000004461,netropsin,Stitch,6.52E-04,1.00E+00,2.90E-02,3.09E-01,5,56,"PFKP,DST,TSPO,PLAT,GPI" Drug,CID000004792,phorbol acetate myristate,Stitch,6.56E-04,1.00E+00,2.91E-02,3.10E-01,32,1399,"GP6,ETS2,ISG20,CHGA,CHGB,NR4A1,SST,STX1B,DST,SCG2,FGF2,SYT1,PLAT,SMG6,RAF1,CACNB1,FOSB,TNIP2,DUSP2,KAT6A,SHC1,NR4A2,STMN1,RGS2,LDLR,S1PR3,EDN1,EGR1,EGR2,CD59,SNAP25,BBC3" Drug,ctd:D015034,Zinc Oxide,CTD,6.57E-04,1.00E+00,2.91E-02,3.10E-01,12,317,"PCSK2,CHGA,CHGB,SST,INKA2,C1QL1,SCG2,SYT1,AMIGO2,RGS4,MACF1,SNAP25" Drug,CID000001229,"2,5-dimethoxy-4-iodoamphetamine",Stitch,6.59E-04,1.00E+00,2.92E-02,3.11E-01,7,117,"A1BG,COX5A,PTPRN,TAC1,HTR1B,FOSB,RIT1" Drug,ctd:D003703,Demecolcine,CTD,6.64E-04,1.00E+00,2.93E-02,3.13E-01,23,878,"CENPF,WDR33,ANKRD37,GBP1,MCCC2,TNFRSF10B,CITED2,MDN1,SP140L,BASP1,LBH,ARRDC3,MED17,TAP1,DYRK2,ZNF652,DUSP2,DUSP4,DUSP6,NR4A2,EGR1,EGR2,ANKRD33B" Drug,5290_UP,Fluvastatin sodium salt [93957-55-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.72E-04,1.00E+00,2.94E-02,3.13E-01,9,191,"NAB2,ISG20,DTX4,PXN,VPS39,SP110,LDLR,PDP1,PLK4" Drug,844_UP,5253409; Up 200; 17uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,6.72E-04,1.00E+00,2.94E-02,3.13E-01,9,191,"ETS2,ETV5,IER5,C17orf80,SYNM,DUSP4,SP110,LDLR,EGR1" Drug,5729_UP,Disulfiram [97-77-8]; Up 200; 13.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,6.72E-04,1.00E+00,2.94E-02,3.13E-01,9,191,"PCSK1,INKA2,ARC,SYT5,HS3ST2,RASA3,FOSB,ARL4D,EGR1" Drug,3377_UP,Equilin [474-86-2]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.72E-04,1.00E+00,2.94E-02,3.13E-01,9,191,"NAB2,U2AF2,SYNDIG1,HS3ST2,DYRK3,EDN1,EGR1,MX1,MYBL1" Drug,7379_DN,Halcinonide [3093-35-4]; Down 200; 8.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,6.72E-04,1.00E+00,2.94E-02,3.13E-01,9,191,"SOX4,ETV5,GBP1,SSBP2,CITED2,SEMA3F,RGS4,TLE4,MPZL2" Drug,CID000006597,dichloroacetate,Stitch,6.73E-04,1.00E+00,2.94E-02,3.13E-01,6,85,"ACOX1,PLAT,NPTX2,FSD1,PDP1,MX1" Drug,CID000002818,clozapine,Stitch,6.77E-04,1.00E+00,2.95E-02,3.15E-01,11,274,"ISG20,CHGA,NR4A1,BDNF,SCG2,TSPO,SYT5,HTR1B,FOSB,RGS2,EGR1" Drug,2271_DN,Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"SPRY2,NR4A1,RNF43,ITPKB,PXN,SUPT20H,RBMS2,MICAL2,WDFY3" Drug,5238_UP,"estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"CENPF,ETS2,ETV5,INKA2,LYVE1,ARC,SEMA3F,CACNB1,MYBL1" Drug,849_DN,retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Down,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"ISG20,TNFRSF10B,ITPKB,DYRK3,PMP22,SEMA3F,LDLR,TRIM3,MYLIP" Drug,3391_UP,Monobenzone [103-16-2]; Up 200; 20uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"ETS2,SYNDIG1,NR4A1,C1QL1,TMPRSS3,NPTX2,NR4A2,EGR1,MX1" Drug,3925_DN,Deltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"NR4A1,KCNF1,ARC,DYRK3,SEMA3F,DUSP2,FAM131A,EDN1,TLE4" Drug,2261_UP,Antimycin A [1397-94-0]; Up 200; 7.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"GJD2,CENPF,SERPINF1,ETV5,CNN3,RFX3,TGIF1,EGR4,MX1" Drug,5955_UP,estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"SPRY2,U2AF2,NR4A1,GPR3,CACNB1,DUSP6,NR4A2,TRIM3,LRIG1" Drug,3041_UP,Luteolin [491-70-3]; Up 200; 14uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,6.97E-04,1.00E+00,3.00E-02,3.19E-01,9,192,"NR4A1,FOSB,DUSP4,NR4A2,NR4A3,TRIM3,OVGP1,EGR1,CD59" Drug,ctd:C410733,scriptaid,CTD,7.07E-04,1.00E+00,3.04E-02,3.23E-01,5,57,"NR4A1,ANAPC1,DUSP6,NR4A3,RGS2" Drug,ctd:D010622,Phencyclidine,CTD,7.16E-04,1.00E+00,3.05E-02,3.25E-01,6,86,"KCNIP3,TAC1,GCC1,FOSB,NR4A2,RGS4" Drug,ctd:D008558,Melphalan,CTD,7.19E-04,1.00E+00,3.05E-02,3.25E-01,11,276,"TRMT10C,DST,SPTY2D1,SHROOM3,FOSB,DUSP2,NR4A3,RGS2,EDN1,CITED4,RBM24" Drug,CID000038368,"5,7-DHT",Stitch,7.20E-04,1.00E+00,3.05E-02,3.25E-01,4,33,"SST,TAC1,HTR1B,SYNM" Drug,CID005310945,NF449,Stitch,7.20E-04,1.00E+00,3.05E-02,3.25E-01,4,33,"ADM,RAF1,VWF,RHO" Drug,CID005311003,alpha-neoendorphin,Stitch,7.20E-04,1.00E+00,3.05E-02,3.25E-01,4,33,"PCSK2,PDYN,SST,TAC1" Drug,3429_UP,Diethylstilbestrol [56-53-1]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.23E-04,1.00E+00,3.05E-02,3.25E-01,9,193,"NAB2,ETS2,ISG20,ADM,TMPRSS3,ZNF652,NR4A2,RGS2,MYBL1" Drug,1183_UP,Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,7.23E-04,1.00E+00,3.05E-02,3.25E-01,9,193,"CENPF,NAB2,U2AF2,NR4A1,AMIGO2,PMP22,NR4A2,NR4A3,CD59" Drug,5932_UP,"rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,7.23E-04,1.00E+00,3.05E-02,3.25E-01,9,193,"TNFRSF10B,DSTYK,TMEM231,AMIGO2,PLSCR4,SUPT20H,GPR19,NR4A2,BBC3" Drug,1834_DN,Meticrane [1084-65-7]; Down 200; 14.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,7.23E-04,1.00E+00,3.05E-02,3.25E-01,9,193,"NAB2,ETS2,ETV5,TNFRSF10B,VPS39,NR4A2,SP110,LDLR,MX1" Drug,3850_UP,Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.23E-04,1.00E+00,3.05E-02,3.25E-01,9,193,"MAPKAPK2,NAB2,ETV5,NKTR,SEMA3F,CACNB1,DUSP4,KAT6A,EGR1" Drug,ctd:C046012,pentanal,CTD,7.27E-04,1.00E+00,3.06E-02,3.26E-01,34,1529,"A1BG,BRPF3,MSC,ZNF154,WDR33,TUBB2B,KCNIP3,EPM2AIP1,ANAPC1,KCNF1,TMPRSS3,PXN,ARC,LBH,PLAT,DCLK2,TMEM231,FHL2,ZNF367,PODXL,ZNF652,DUSP6,FSD1,RGS2,TRIM3,OPHN1,CORO1A,CITED4,EGR1,EGR2,EGR4,CELF3,PATJ,MX1" Drug,1786_UP,Chelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; HL60; HG-U133A,Broad Institute CMAP Up,7.36E-04,1.00E+00,3.09E-02,3.29E-01,8,155,"SPRY2,ETS2,SSBP2,ISG20,NR4A1,DUSP4,NR4A2,NR4A3" Drug,6774_DN,Anabasine [494-52-0]; Down 200; 24.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"ARC,C17orf80,ZNF329,NR4A2,SP110,OVGP1,MAP4K5,WDFY3,BBC3" Drug,4738_DN,Graveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"ETV5,NKTR,TAF1,SEMA3F,ZNF652,ZNF254,TRIM3,PDP1,PLK4" Drug,5855_UP,Harmine hydrochloride [343-27-1]; Up 200; 16uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"GP6,C1QL1,CITED2,TMEM231,SEMA3F,GPR19,EGR1,MICAL2,SNAP25" Drug,6933_DN,17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"MAPKAPK2,U2AF2,PXN,HES1,GPR19,DUSP4,MAP4K5,PDP1,FUT1" Drug,5355_UP,Lynestrenol [52-76-6]; Up 200; 14uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"MAPKAPK2,ISG20,TAF1,SEMA3F,DUSP4,OVGP1,EGR1,MICAL2,MYBL1" Drug,5954_UP,PF-00562151-00 [351320-12-2]; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.51E-04,1.00E+00,3.11E-02,3.31E-01,9,194,"ETV5,U2AF2,NR4A1,DYRK3,CACNB1,DUSP4,DUSP6,NR4A2,EGR1" Drug,ctd:C432165,pyrazolanthrone,CTD,7.53E-04,1.00E+00,3.11E-02,3.31E-01,12,322,"MAPKAPK2,TNFRSF10B,NR4A1,BDNF,KCNE4,FGF2,TAC1,PLAT,SHC1,LDLR,EDN1,EGR1" Drug,CID000069882,pentafluorobenzonitrile,Stitch,7.74E-04,1.00E+00,3.11E-02,3.31E-01,3,15,"NKTR,RAF1,DUSP2" Drug,ctd:C405354,"4,5,6,7-tetrabromobenzotriazole",CTD,7.74E-04,1.00E+00,3.11E-02,3.31E-01,3,15,"NR4A1,BDNF,ARC" Drug,CID000445957,1h08,Stitch,7.74E-04,1.00E+00,3.11E-02,3.31E-01,3,15,"RNF112,VWF,FOSB" Drug,6870_DN,SC-560; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"MAPKAPK2,NAB2,ETS2,TMPRSS3,PXN,ARC,SEMA3F,LDLR,TRIM3" Drug,5388_DN,Butoconazole nitrate [32872-77-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"NAB2,B4GALT6,INKA2,DSTYK,SEMA3F,GPR19,KAT6A,ZNF254,LAMB3" Drug,7255_UP,Moxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"NAB2,B4GALT6,ANOS1,SCG2,FGF2,SYT1,AMIGO2,RBMS2,EGR4" Drug,4960_UP,Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"GBP1,ISG20,SCG2,SYT5,C17orf80,FAM131A,RHO,FSTL1,EGR1" Drug,2966_DN,Ioxaglic acid [59017-64-0]; Down 200; 3.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"ISG20,AMIGO2,DYRK3,DYRK2,DUSP4,POT1,NR4A2,AACS,MX1" Drug,505_DN,17-AAG; Down 200; 1uM; SKMEL5; HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"SPRY2,NAB2,NR4A1,DYRK2,PODXL,DUSP6,NR4A2,NR4A3,EGR1" Drug,5359_DN,Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"CLK4,SSBP2,DSTYK,MCRS1,VPS39,RIT1,SYNGR3,PRKAB2,CD59" Drug,6330_UP,Budesonide [51333-22-3]; Up 200; 9.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"WDR33,MAPKAPK2,NR4A1,DSTYK,PLAT,GPR3,CACNB1,FSD1,BBC3" Drug,3268_UP,Cyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"INKA2,C1QL1,ARC,FGF2,TAF1,SEMA3F,GPR3,KAT6A,PATJ" Drug,2973_DN,Pivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"NAB2,ISG20,NKTR,SEMA3F,RASA3,ZNF254,NR4A3,SP110,MX1" Drug,1974_UP,Pyrimethamine [58-14-0]; Up 200; 16uM; HL60; HG-U133A,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"ETV5,BBX,DTX4,ZNF160,ZNF652,DUSP2,OVGP1,AACS,MX1" Drug,4664_DN,3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"SSBP2,NR4A1,C1QL1,SUPT20H,FAM131A,SYNGR3,PRKAB2,FUT1,PATJ" Drug,866_UP,ikarugamycin; Up 200; 2uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"ETV5,PLAT,DUSP4,NR4A2,SP110,LDLR,WDFY3,PATJ,PLK4" Drug,7460_DN,Etomidate [33125-97-2]; Down 200; 16.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,7.78E-04,1.00E+00,3.11E-02,3.31E-01,9,195,"ETS2,DSTYK,TMEM231,NR4A2,SP110,EGR1,TLE4,FUT1,BBC3" Drug,3141_UP,Dimaprit dihydrochloride [23256-33-9]; Up 200; 17uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.00E-04,1.00E+00,3.11E-02,3.31E-01,8,157,"MAPKAPK2,ISG20,NR4A1,DUSP4,NR4A2,LAMB3,NR4A3,MICAL2" Drug,ctd:C076029,olanzapine,CTD,8.05E-04,1.00E+00,3.11E-02,3.31E-01,7,121,"A1BG,ACOX1,KCNIP3,BDNF,FGF2,LDLR,SNAP25" Drug,7506_UP,pioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"GP6,MAPKAPK2,ISG20,TNFRSF10B,ITPKB,TMEM231,SMG6,SEMA3F,PATJ" Drug,6777_DN,Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"MAPKAPK2,ETS2,B4GALT6,ARC,DNM1,FSD1,SP110,OVGP1,PLK4" Drug,2063_UP,Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"NAB2,ETV5,GPR19,KAT6A,NR4A2,RGS4,ARL4D,CORO1A,KLHL36" Drug,7426_UP,Pimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"GP6,SPRY2,NR4A1,DUSP2,DUSP4,LDLR,EGR1,EGR4,BBC3" Drug,2073_UP,Thioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"GBP1,DSTYK,DYRK2,NR4A2,LDLR,RGS4,ARL4D,OVGP1,PRKAB2" Drug,3762_DN,Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CENPF,NAB2,NR4A1,SCG2,ARC,SYT1,KAT6A,NR4A2,PATJ" Drug,6028_DN,Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"ZNF136,CNKSR1,SSBP2,SP140L,KCNF1,PXN,SEMA3F,TRIM3,PATJ" Drug,347_UP,2-propylpentanoic acid; Up 200; 500uM; MCF7; HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CNKSR1,ETV5,TNFRSF10B,ITPKB,DTX4,CACNB1,CORO1A,SYNGR3,HCRTR2" Drug,5984_DN,Meticrane [1084-65-7]; Down 200; 14.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"ZNF136,U2AF2,TNFRSF10B,B4GALT6,DSTYK,TAF1,ZNF160,ZNF652,BBC3" Drug,2229_DN,Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"ZNF136,NAB2,TNFRSF10B,PXN,ARC,DUSP2,LAMB3,SP110,OVGP1" Drug,4539_DN,Flutamide [13311-84-7]; Down 200; 14.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"SOX4,FAM168B,CENPF,SEMA3F,FSD1,CORO1A,FUT1,PATJ,MX1" Drug,4307_UP,Pempidine tartrate [546-48-5]; Up 200; 13uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"PXN,CACNB1,NPTX2,GPR19,NR4A2,RGS4,TRIM3,BBC3,PLK4" Drug,7502_UP,CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CENPF,TMEM231,SMG6,PLSCR4,SEMA3F,EDN1,ARL4D,PATJ,BBC3" Drug,6029_DN,Famprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CNKSR1,WDR33,NAB2,TNFRSF10B,NR4A1,ADM,NR4A2,FAM131A,MICAL2" Drug,2876_DN,Trimetazidine dihydrochloride [13171-25-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CNKSR1,TBC1D2B,TNFRSF10B,DTX4,DYRK3,SEMA3F,VPS39,ZNF254,LAMB3" Drug,1082_UP,haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"ZNF184,ETS2,TNFRSF10B,PXN,SYT1,C17orf80,SUPT20H,DUSP4,EGR1" Drug,1333_UP,"Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Up 200; 4.8uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"WDR33,MAPKAPK2,NR4A1,CITED2,PXN,PMP22,RASA3,ZNF254,TLE4" Drug,4182_DN,Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"NR4A1,INKA2,LYVE1,ARC,SYT5,DYRK3,PLSCR4,FSTL1,SNAP25" Drug,7408_UP,Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"MAPKAPK2,INKA2,PXN,FHL2,SEMA3F,DUSP2,LRIG1,EGR1,MYBL1" Drug,6203_DN,haloperidol; Down 200; 10uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"WDR33,NAB2,DYRK3,SEMA3F,CACNB1,NR4A2,ARL4D,CD59,WDFY3" Drug,6227_DN,2-Chloropyrazine [14508-49-7]; Down 200; 35uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"CNKSR1,MAPKAPK2,SSBP2,SUPT20H,DUSP4,SP110,FUT1,MPZL2,PLK4" Drug,6363_UP,PF-01378883-00 [351320-41-7]; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.07E-04,1.00E+00,3.11E-02,3.31E-01,9,196,"ETV5,NR4A1,SYT5,CACNB1,FOSB,DUSP4,DUSP6,EDN1,CELF3" Drug,CID005091655,EMCs,Stitch,8.08E-04,1.00E+00,3.11E-02,3.31E-01,4,34,"A1BG,NR4A1,NR4A2,NR4A3" Drug,ctd:C020806,tetrabromobisphenol A,CTD,8.09E-04,1.00E+00,3.11E-02,3.31E-01,23,891,"SOX4,WDR33,NAB2,HLA-E,MIF4GD,STYXL2,SLC25A25,PTPRN,HYAL3,LBH,FHL2,AMIGO2,PMP22,PLSCR4,SYNM,DUSP2,DUSP4,SP110,NACC2,EGR1,SPRY4,MYLIP,SNAP25" Drug,6337_UP,Doxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"GP6,ETV5,SYNDIG1,CITED2,CACNB1,TRIM3,MPZL2,BBC3,HCRTR2" Drug,3685_UP,Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"NAB2,ARC,LBH,SYT1,NPTX2,KAT6A,RGS4,EDN1,PATJ" Drug,1287_UP,Bisoprolol fumarate; Up 200; 9uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"WDR33,TNFRSF10B,CACNB1,GPR19,RASA3,DUSP6,ZNF254,SP110,PLK4" Drug,1635_UP,alpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"ZNF136,NAB2,ETS2,B4GALT6,ADM,TMPRSS3,FHL2,CACNB1,MYBL1" Drug,4787_DN,Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"ACOX1,TNFRSF10B,TMEM231,NR4A2,SP110,LRIG1,MICAL2,MAP4K5,MPZL2" Drug,4803_UP,Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"GP6,SSBP2,PLAT,DYRK3,GPR3,CACNB1,HTR1B,POT1,WDFY3" Drug,2814_DN,Sulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"CENPF,TBC1D2B,ETS2,B4GALT6,PXN,TMEM231,CHPF,SP110,TRIM3" Drug,1933_UP,Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; PC3; HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"BDNF,ANOS1,ZNF160,SEMA3F,PODXL,DUSP4,CHSY1,FAM131A,NACC2" Drug,2641_DN,Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"MAPKAPK2,SERPINF1,U2AF2,TNFRSF10B,ADM,PXN,GPR19,ZNF329,LAMB3" Drug,5332_DN,N6-methyladenosine [1867-73-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"FAM168B,NAB2,DSTYK,BRPF1,TMPRSS3,MCRS1,RBMS2,LRIG1,PDP1" Drug,2149_DN,Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"NR4A1,PMP22,CACNB1,GPR19,FOSB,DUSP2,ZNF254,BBC3,MX1" Drug,503_DN,"indomethacin, USP; Down 200; 100uM; SKMEL5; HG-U133A",Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"SSBP2,NR4A1,B4GALT6,LYVE1,DYRK3,DYRK2,STMN1,FADS1,EGR4" Drug,2879_UP,Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"CENPF,ETV5,ARC,ZNF652,DUSP2,ZNF329,NR4A2,RHO,FSTL1" Drug,6466_DN,Bephenium hydroxynaphthoate [3818-50-6]; Down 200; 9uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"ZNF136,MAPKAPK2,GBP1,B4GALT6,DSTYK,ZNF160,ZNF652,OVGP1,BBC3" Drug,2186_UP,Evoxine [522-11-2]; Up 200; 11.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"GJD2,MAPKAPK2,C1QL1,PLAT,CHPF,PLSCR4,CACNB1,TRIM3,EGR4" Drug,1529_DN,Famotidine [76824-35-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"TNFRSF10B,NKTR,TAF1,SEMA3F,FAM131A,SP110,TRIM3,EGR1,MYLIP" Drug,1013_DN,rosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"MAPKAPK2,NAB2,ETS2,U2AF2,ADM,DYRK3,VPS39,SP110,PATJ" Drug,5322_DN,Benserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"SSBP2,KCNK1,DYRK2,SUPT20H,POT1,PRKAB2,MARF1,MACF1,PLK4" Drug,6791_DN,Berberine chloride [633-65-8]; Down 200; 10.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"NAB2,ISG20,ARC,NKTR,CHPF,C17orf80,CORO1A,MAP4K5,RAB15" Drug,4497_UP,Clobetasol propionate [25122-46-7]; Up 200; 8.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"GP6,CENPF,PLAT,HTR1B,ZNF652,NR4A3,SP110,EGR1,BBC3" Drug,6771_DN,Monocrotaline [315-22-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"NAB2,UBR5,ARC,C17orf80,DYRK2,RBMS2,RGS2,MAP4K5,PDP1" Drug,3443_DN,Monensin sodium salt [22373-78-0]; Down 200; 5.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"DTX4,PXN,C17orf80,DYRK2,SEMA3F,ZNF652,KAT6A,SP110,NACC2" Drug,5675_DN,Colchicine [64-86-8]; Down 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"SPRY2,SCG2,DTX4,TMPRSS3,SEMA3F,FSD1,RGS2,OVGP1,PLK4" Drug,1997_UP,"Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; HL60; HG-U133A",Broad Institute CMAP Up,8.37E-04,1.00E+00,3.11E-02,3.31E-01,9,197,"ACOX1,ETV5,CITED2,DYRK2,LDLR,OVGP1,PDP1,AACS,MX1" Drug,CID000001233,ibotenic acid,Stitch,8.45E-04,1.00E+00,3.13E-02,3.34E-01,7,122,"PDYN,SST,BDNF,HTR1B,SYNM,EGR4,MAP4K5" Drug,ctd:C101044,tyrphostin AG 1478,CTD,8.45E-04,1.00E+00,3.13E-02,3.34E-01,7,122,"FGF2,TAC1,HES1,FOSB,SHC1,EDN1,EGR1" Drug,5532_DN,Rilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"ETS2,U2AF2,RNF43,KCNF1,TMPRSS3,DUSP2,POT1,MACF1,FUT1" Drug,1541_UP,Chlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SERPINF1,ISG20,DYRK3,CACNB1,DUSP6,KAT6A,OVGP1,EGR1,EGR4" Drug,6026_UP,Deltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"TBC1D2B,B4GALT6,INKA2,PLPPR4,CACNB1,RASA3,ZNF329,TRIM3,OVGP1" Drug,7445_DN,Piroxicam [36322-90-4]; Down 200; 12uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"TMPRSS3,VPS39,DUSP4,ZNF254,FSD1,TRIM3,LRIG1,PDP1,WDFY3" Drug,4150_DN,Thyroxine (L) [51-48-9]; Down 200; 5.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SERPINF1,ADM,LYVE1,SYT5,PLSCR4,DUSP4,FAM131A,TRIM3,MX1" Drug,5259_DN,3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"CENPF,TNFRSF10B,RNF43,DSTYK,ZNF652,ZNF329,LAMB3,TRIM3,BBC3" Drug,6202_UP,wortmannin from Penicillium funiculosum; Up 200; 0.01uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"ISG20,PLPPR4,KCNK1,HS3ST2,CACNB1,SP110,RHO,KLHL36,MX1" Drug,6019_DN,Quinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SPRY2,ZNF136,NAB2,ITPKB,BRPF1,ARC,DYRK3,ZNF329,FAM131A" Drug,6550_UP,PHA-00767505E [723337-45-9]; Up 200; 10uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SPRY2,ZNF136,ISG20,DYRK3,KAT6A,ARL4D,LRIG1,KLHL36,WDFY3" Drug,123_UP,dexamethasone; Up 200; 1uM; MCF7; HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"ZNF136,CNKSR1,PTPRN,SEMA3F,VPS39,TENT5A,LDLR,EGR1,EGR4" Drug,4071_UP,Dihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"GJD2,ARC,SYT5,CACNB1,FOSB,NR4A2,LDLR,LRIG1,KLHL36" Drug,6016_DN,Nifenazone [2139-47-1]; Down 200; 13uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"U2AF2,NR4A1,B4GALT6,ITPKB,PXN,DNM1,TRIM3,TLE4,PATJ" Drug,6139_UP,D-cycloserine [68-41-7]; Up 200; 39.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SOX4,SYNDIG1,CHGB,PLPPR4,DSTYK,CACNB1,KLHL36,CELF3,SNAP25" Drug,7163_DN,Suxibuzone [27470-51-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"SSBP2,NR4A1,PMP22,VPS39,DUSP4,ZNF254,EGR1,SYNGR3,PRKAB2" Drug,3703_UP,Folinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"TNFRSF10B,NR4A1,KCNF1,ARC,SYT1,NR4A2,RGS4,PATJ,BBC3" Drug,7218_DN,Avermectin B1 [71751-41-2]; Down 200; 4.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.67E-04,1.00E+00,3.13E-02,3.34E-01,9,198,"U2AF2,DSTYK,NKTR,DYRK2,SUPT20H,ZNF652,SP110,LRIG1,PATJ" Drug,4325_UP,Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.68E-04,1.00E+00,3.13E-02,3.34E-01,8,159,"ETS2,AMIGO2,DYRK3,NR4A2,LDLR,RGS4,EDN1,EGR1" Drug,CID000001781,"5,8,11-eicosatriynoic acid",Stitch,8.95E-04,1.00E+00,3.13E-02,3.34E-01,5,60,"A1BG,STRN4,PLAT,NPTX2,EDN1" Drug,ctd:C517041,"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)",CTD,8.98E-04,1.00E+00,3.13E-02,3.34E-01,15,472,"SPRY2,MSC,ETV5,IER5,ARC,HES1,GCC1,DYRK3,FOSB,DUSP2,DUSP4,NR4A2,RGS2,RGS4,IFRD1" Drug,5795_UP,Demecarium bromide [56-94-0]; Up 200; 5.6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"TBC1D2B,KCNE4,FGF2,SYT5,TAC1,SEMA3F,DUSP2,PATJ,PLK4" Drug,6505_UP,Gliquidone [33342-05-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"GBP1,CHGB,BDNF,TMPRSS3,NKTR,TAF1,PLSCR4,TRIM3,OVGP1" Drug,2337_UP,Kawain [500-64-1]; Up 200; 17.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"RNF43,SYT5,CHPF,PMP22,TRIM3,OVGP1,EGR1,AACS,PLK4" Drug,6491_UP,"(+,-)-Octopamine hydrochloride [770-05-8]; Up 200; 21uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"MAPKAPK2,ETV5,SYNDIG1,ISG20,NR4A1,FGF2,SMG6,CACNB1,FSTL1" Drug,1581_UP,Chlorthalidone [77-36-1]; Up 200; 11.8uM; HL60; HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"SOX4,NAB2,ETV5,TNIP2,DUSP2,SHC1,LBR,OVGP1,CEP57" Drug,2205_UP,Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"NAB2,NR4A1,PXN,NKTR,CHPF,CACNB1,FOSB,OVGP1,MPZL2" Drug,6164_UP,"aspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"CNKSR1,SYNDIG1,B4GALT6,PXN,ARC,NPTX2,NR4A2,TRIM3,KLHL36" Drug,4843_DN,Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"RNF43,ADM,C17orf80,SEMA3F,FAM131A,SP110,RGS2,OVGP1,FSTL1" Drug,1521_UP,Cyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"SERPINF1,ETV5,INKA2,RASA3,DUSP2,LAMB3,TRIM3,ARL4D,EGR1" Drug,5695_DN,S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"B4GALT6,ITPKB,KCNF1,TAF1,GPR3,VPS39,DUSP2,WDFY3,PLK4" Drug,2819_DN,beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"CENPF,MAPKAPK2,ETS2,ADM,DNM1,ZNF329,TRIM3,PATJ,MX1" Drug,7126_DN,Oxybutynin chloride [1508-65-2]; Down 200; 10.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"SSBP2,B4GALT6,DSTYK,BRPF1,FGF2,MCRS1,CHPF,RGS4,MAP4K5" Drug,7030_DN,"Laudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A",Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"CNKSR1,CENPF,MAPKAPK2,ACOX1,NAB2,ISG20,TNFRSF10B,SUPT20H,SP110" Drug,7170_DN,Isoetharine mesylate salt [7279-75-6]; Down 200; 12uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"CNKSR1,NAB2,NR4A1,KCNF1,DSTYK,TMEM231,VPS39,PODXL,BBC3" Drug,1469_DN,Dibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"ITPKB,SP140L,PXN,NKTR,DYRK3,DUSP4,LDLR,KLHL36,AACS" Drug,1493_DN,Acebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"ETS2,TNFRSF10B,ADM,PXN,SEMA3F,RBMS2,DUSP2,SYNGR3,PLK4" Drug,4687_DN,Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"B4GALT6,PXN,PLAT,SMG6,DUSP2,TRIM3,OVGP1,EGR1,SYNGR3" Drug,2730_UP,Cephapirin sodium salt [24356-60-3]; Up 200; 9uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,8.99E-04,1.00E+00,3.13E-02,3.34E-01,9,199,"SYNDIG1,KCNE4,CNN3,SYNM,DUSP4,RGS4,MICAL2,PLK4,MX1" Drug,CID000000365,AC1L192V,Stitch,9.03E-04,1.00E+00,3.13E-02,3.34E-01,4,35,"ACOX1,SCG2,PPAT,FADS1" Drug,CID000001206,MAMP,Stitch,9.04E-04,1.00E+00,3.13E-02,3.34E-01,8,160,"PDYN,NR4A1,BDNF,PLAT,HTR1B,DUSP6,NR4A2,RGS2" Drug,ctd:C102280,LY 306740,CTD,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"PDYN,TAC1" Drug,CID000007993,dimethylaminopropylamine,Stitch,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"LDLR,MX1" Drug,ctd:C499293,"(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide",CTD,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"SST,TAC1" Drug,CID000100148,Boc-lysine,Stitch,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"PDYN,LYVE1" Drug,ctd:C118602,triethyl-(beta-4-stilbenoxyethyl)ammonium,CTD,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"FGF2,EGR1" Drug,CID000334924,NSC-342209,Stitch,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"PDYN,LYVE1" Drug,ctd:C470148,nilestriol,CTD,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"VWF,EDN1" Drug,CID000130280,NSC 303861,Stitch,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"PPAT,MX1" Drug,ctd:C096324,botulinum toxin type C,CTD,9.09E-04,1.00E+00,3.13E-02,3.34E-01,2,4,"STX1B,SNAP25" Drug,CID000000478,AC1N9TEG,Stitch,9.30E-04,1.00E+00,3.17E-02,3.37E-01,7,124,"CHGB,ITPKB,SYT1,TAF1,RASA3,PLEKHA4,SHC1" Drug,2167_UP,Benzocaine [94-09-7]; Up 200; 24.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"SOX4,ISG20,DSTYK,MCRS1,GPR19,FOSB,NR4A2,CD59,MYBL1" Drug,6206_DN,Ricinine [524-40-3]; Down 200; 24.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"MAPKAPK2,U2AF2,TNFRSF10B,SP140L,GCC1,SYNM,DUSP4,EGR1,RAB15" Drug,3735_UP,PNU-0230031 [267429-39-0]; Up 200; 1uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"SUPT20H,GPR19,DUSP2,ZNF254,NR4A2,RGS4,LRIG1,MAP4K5,BBC3" Drug,3020_DN,Nadolol [42200-33-9]; Down 200; 13uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"SOX4,NAB2,SYNDIG1,TMEM231,DUSP4,ZNF254,NR4A2,RHO,MYBL1" Drug,6679_DN,Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Down,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"CENPF,NAB2,NKTR,CACNB1,TENT5A,NR4A2,ARL4D,TLE4,SYNGR3" Drug,1692_UP,Nifedipine [21829-25-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"NAB2,TBC1D2B,GBP1,NR4A1,FGF2,DUSP4,KAT6A,SP110,EGR1" Drug,2323_DN,Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"GBP1,ITPKB,DSTYK,TAF1,DYRK3,KAT6A,ARL4D,OVGP1,PATJ" Drug,7229_DN,Gabapentin [60142-96-3]; Down 200; 23.4uM; MCF7; HT_HG-U133A,Broad Institute CMAP Down,9.31E-04,1.00E+00,3.17E-02,3.37E-01,9,200,"SOX4,MAPKAPK2,PXN,DYRK2,VPS39,SP110,EGR1,TLE4,SYNGR3" Drug,ctd:D010862,Pilocarpine,CTD,9.34E-04,1.00E+00,3.17E-02,3.38E-01,11,285,"PCSK1,BDNF,FGF2,TAC1,CNN3,NPTX2,HTR1B,FOSB,APEX1,EGR1,EGR2" Drug,5022_UP,Maprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,9.42E-04,1.00E+00,3.19E-02,3.40E-01,8,161,"ETV5,ISG20,DUSP4,DUSP6,LDLR,EDN1,EGR1,BBC3" Drug,7068_UP,MG-262; Up 200; 0.1uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,9.42E-04,1.00E+00,3.19E-02,3.40E-01,8,161,"IER5,ADM,FGF2,AMIGO2,TENT5A,DUSP2,LDLR,EDN1" Drug,CID000097054,NSC 97945,Stitch,9.44E-04,1.00E+00,3.19E-02,3.40E-01,3,16,"TAC1,RHO,PDP1" Drug,CID000000764,guanine,Stitch,9.53E-04,1.00E+00,3.22E-02,3.43E-01,23,902,"GBP1,TUBB2B,NCL,SST,TUBB6,ANOS1,DOCK2,RAF1,HTR1B,SUPT20H,RASA3,SYNM,SHC1,APEX1,PPAT,LDLR,RGS4,RHO,ARL4D,RIT1,EGR1,MT-ND1,RAB15" Drug,CID000005074,ritanserin,Stitch,9.65E-04,1.00E+00,3.26E-02,3.47E-01,5,61,"PDYN,BDNF,TAC1,HTR1B,RIT1" Drug,CID000002900,isocycloheximide,Stitch,9.95E-04,1.00E+00,3.35E-02,3.57E-01,23,905,"GP6,ATP6V0C,GJD2,ISG20,TNFRSF10B,NR4A1,BDNF,DST,SCG2,FGF2,SYT1,TAC1,PLAT,FOSB,NR4A2,RGS2,LDLR,EDN1,EGR1,EGR2,SERPINB1,SNAP25,BBC3" Drug,CID003392279,A809128,Stitch,1.01E-03,1.00E+00,3.39E-02,3.61E-01,4,36,"NCL,TSPO,DUSP4,MX1" Drug,ctd:D000069439,Dasatinib,CTD,1.02E-03,1.00E+00,3.42E-02,3.64E-01,15,478,"SOX4,SPRY2,SYNPO2,CENPF,MCM6,CKS2,PXN,LBH,AMIGO2,PLSCR4,STMN1,PPAT,RGS4,PLK4,MYBL1" Drug,CID000001148,DL-tryptophan,Stitch,1.02E-03,1.00E+00,3.43E-02,3.65E-01,7,126,"RNF112,DST,TSPO,HTR1B,SYNM,DUSP4,MX1" Drug,ctd:D009285,Naphthoquinones,CTD,1.03E-03,1.00E+00,3.46E-02,3.68E-01,12,334,"IER5,CITED2,ADM,HES1,ARRDC3,PART1,NR4A2,RGS2,LDLR,RIT1,EGR1,BBC3" Drug,ctd:C028031,cadmium acetate,CTD,1.06E-03,1.00E+00,3.55E-02,3.78E-01,8,164,"NCL,NR4A1,COX5A,FOSB,NR4A2,APEX1,NR4A3,RGS2" Drug,ctd:D003609,Dactinomycin,CTD,1.07E-03,1.00E+00,3.59E-02,3.82E-01,11,290,"IER5,TNFRSF10B,BDNF,TMEFF2,FGF2,PLAT,TAP1,RAF1,EDN1,EGR1,BBC3" Drug,CID006437335,NSC 402447,Stitch,1.08E-03,1.00E+00,3.60E-02,3.84E-01,6,93,"SERPINF1,MCCC2,PTPRN,FGF2,RAF1,SNAP25" Drug,ctd:C007262,deoxynivalenol,CTD,1.08E-03,1.00E+00,3.61E-02,3.85E-01,15,481,"SOX4,SYNPO2,NCL,NR4A1,TAP1,USP30,SYNM,FOSB,DUSP6,NR4A3,STMN1,CORO1A,EGR1,FUT1,BBC3" Drug,CID000123610,Integrilin,Stitch,1.12E-03,1.00E+00,3.72E-02,3.96E-01,4,37,"PLAT,VWF,DUSP2,MPZL2" Drug,CID000327966,AC1L71LN,Stitch,1.12E-03,1.00E+00,3.72E-02,3.96E-01,7,128,"PCSK1,PCSK2,CHGA,SST,PTPRN,SCG2,TAF1" Drug,CID000003851,"L-703, 606 oxalate",Stitch,1.14E-03,1.00E+00,3.76E-02,4.01E-01,3,17,"SST,TAC1,EDN1" Drug,CID000444109,prolylleucine,Stitch,1.14E-03,1.00E+00,3.76E-02,4.01E-01,3,17,"TAC1,CHPF,RHO" Drug,2540_UP,Podophyllotoxin [518-28-5]; Up 200; 9.6uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.15E-03,1.00E+00,3.78E-02,4.03E-01,8,166,"ISG20,NR4A1,FOSB,DUSP4,NR4A2,NR4A3,RIT1,PLK4" Drug,6780_UP,Pimozide [2062-78-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.15E-03,1.00E+00,3.78E-02,4.03E-01,8,166,"ETV5,ISG20,TNFRSF10B,NR4A1,DUSP4,DUSP6,LDLR,EGR1" Drug,2885_UP,Parthenolide [20554-84-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.15E-03,1.00E+00,3.78E-02,4.03E-01,8,166,"WDR33,IER5,ISG20,ADM,ZNF329,RGS2,LDLR,EGR1" Drug,ctd:D008774,Methylphenidate,CTD,1.17E-03,1.00E+00,3.86E-02,4.11E-01,7,129,"CHGA,BDNF,ARC,FOSB,EGR1,SUDS3,SNAP25" Drug,1626_UP,Etoposide [33419-42-0]; Up 200; 6.8uM; HL60; HG-U133A,Broad Institute CMAP Up,1.19E-03,1.00E+00,3.91E-02,4.17E-01,8,167,"ETS2,TNFRSF10B,DUSP2,NR4A2,NR4A3,RIT1,EGR1,MX1" Drug,3317_UP,Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.19E-03,1.00E+00,3.91E-02,4.17E-01,8,167,"SERPINF1,ISG20,TNFRSF10B,INKA2,ADM,BBX,GPR3,MPZL2" Drug,CID000560437,MeIle,Stitch,1.20E-03,1.00E+00,3.94E-02,4.19E-01,5,64,"GJD2,SST,BDNF,ANOS1,HTR1B" Drug,ctd:C121565,pifithrin,CTD,1.21E-03,1.00E+00,3.95E-02,4.21E-01,6,95,"CITED2,ADM,RAF1,FOSB,EDN1,BBC3" Drug,ctd:D011899,Ranitidine,CTD,1.23E-03,1.00E+00,4.01E-02,4.27E-01,7,130,"MAPKAPK2,NR4A1,TAC1,RGS2,RGS4,IFRD1,EGR1" Drug,ctd:D004317,Doxorubicin,CTD,1.23E-03,1.00E+00,4.03E-02,4.30E-01,37,1765,"SOX4,CENPF,MATN2,ACOX1,NAB2,ETV5,MCM6,MCCC2,TNFRSF10B,NR4A1,PFKP,CITED2,TUBB6,LYVE1,METRN,COX5A,CIAPIN1,TSPO,NKTR,TAF1,FHL2,TAP1,DUSP4,DUSP6,SHC1,STMN1,CRHBP,EDN1,EGR1,EGR2,MICAL2,MT-ND1,MYLIP,PRKAB2,CD59,BBC3,ANKRD33B" Drug,CID000043849,1H-3,Stitch,1.24E-03,1.00E+00,4.03E-02,4.30E-01,4,38,"ACOX1,UBR5,TSPO,PMP22" Drug,1233_UP,rosiglitazone; Up 200; 10uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.24E-03,1.00E+00,4.03E-02,4.30E-01,8,168,"CITED2,ADM,DTX4,AMIGO2,DYRK2,RGS4,IFRD1,MX1" Drug,CID000001207,MK-801,Stitch,1.27E-03,1.00E+00,4.12E-02,4.39E-01,11,296,"PDYN,SST,BDNF,COX5A,ARC,TAC1,HTR1B,FOSB,RGS2,EGR1,EGR2" Drug,6724_UP,Digoxin [20830-75-5]; Up 200; 5.2uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.29E-03,1.00E+00,4.18E-02,4.45E-01,8,169,"ZNF136,ETS2,IER5,ADM,ARC,NR4A2,EDN1,EGR1" Drug,CID005315496,AC1NST48,Stitch,1.32E-03,1.00E+00,4.26E-02,4.54E-01,17,594,"PCSK1,PCSK2,NCL,CHGB,B4GALT6,ITPKB,SCG2,STRN4,GCC1,DNM1,CHPF,VPS39,LDLR,TRIM3,ARL4D,SEC22C,SNAP25" Drug,978_UP,pyrvinium pamoate; Up 200; 1.25uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.34E-03,1.00E+00,4.31E-02,4.60E-01,8,170,"ETS2,ETV5,TNFRSF10B,ADM,EGR1,SYNGR3,FUT1,BBC3" Drug,7053_UP,thapsigargin; Up 200; 0.1uM; MCF7; HT_HG-U133A,Broad Institute CMAP Up,1.34E-03,1.00E+00,4.31E-02,4.60E-01,8,170,"WDR33,ETS2,ETV5,ISG20,GCC1,LDLR,SYNGR3,FUT1" Drug,6736_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.34E-03,1.00E+00,4.31E-02,4.60E-01,8,170,"PLPPR4,SYT1,DYRK3,PLSCR4,NR4A2,RGS4,CORO1A,MYBL1" Drug,CID000104742,Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol,Stitch,1.35E-03,1.00E+00,4.35E-02,4.64E-01,3,18,"PDYN,SST,HTR1B" Drug,CID003033934,2-oleoyl-1-stearoyl-sn-glycero-3-phosphocholine,Stitch,1.35E-03,1.00E+00,4.35E-02,4.64E-01,3,18,"PCSK2,BASP1,RHO" Drug,CID000001225,SKF 82958,Stitch,1.37E-03,1.00E+00,4.39E-02,4.67E-01,4,39,"PDYN,SYT1,DUSP4,EGR1" Drug,CID000100208,Dolastatin 10,Stitch,1.37E-03,1.00E+00,4.39E-02,4.67E-01,4,39,"TUBB2B,TUBB6,STMN1,MX1" Drug,2723_DN,Cycloheximide [66-81-9]; Down 200; 14.2uM; HL60; HT_HG-U133A,Broad Institute CMAP Down,1.39E-03,1.00E+00,4.43E-02,4.72E-01,8,171,"SOX4,LGR4,ADM,MCRS1,TMEM231,DUSP2,LDLR,MICAL2" Drug,3791_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.39E-03,1.00E+00,4.43E-02,4.72E-01,8,171,"SSBP2,PLPPR4,SYT1,NPTX2,NR4A2,RGS4,CORO1A,SYNGR3" Drug,2957_UP,Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.39E-03,1.00E+00,4.43E-02,4.72E-01,8,171,"SYNDIG1,NR4A1,BDNF,FOSB,DUSP2,DUSP4,NR4A2,NR4A3" Drug,ctd:D009638,Norepinephrine,CTD,1.39E-03,1.00E+00,4.43E-02,4.72E-01,8,171,"PCSK1,PCSK2,PDYN,FGF2,FOSB,SHC1,EDN1,EGR1" Drug,CID000004624,6-OHDA,Stitch,1.40E-03,1.00E+00,4.47E-02,4.77E-01,10,255,"PDYN,SST,BDNF,FGF2,TAC1,HTR1B,FOSB,NR4A2,EGR1,BBC3" Drug,ctd:C113580,U 0126,CTD,1.42E-03,1.00E+00,4.52E-02,4.82E-01,14,444,"PDYN,BDNF,ARC,FGF2,TAC1,PLAT,RAF1,FOSB,SHC1,LDLR,EDN1,EGR1,EGR2,BBC3" Drug,ctd:C500085,muraglitazar,CTD,1.42E-03,1.00E+00,4.52E-02,4.82E-01,14,444,"SPRY2,ACOX1,CHGB,NR4A1,CITED2,ADM,RASA3,DUSP6,RGS2,RGS4,EGR1,DNAJC5G,FUT1,PATJ" Drug,910_UP,trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.44E-03,1.00E+00,4.57E-02,4.87E-01,8,172,"ISG20,TNFRSF10B,SEMA3F,DUSP4,LDLR,EGR1,TLE4,PATJ" Drug,1050_UP,"Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA",Broad Institute CMAP Up,1.49E-03,1.00E+00,4.68E-02,4.99E-01,8,173,"IER5,SSBP2,ADM,DYRK3,PMP22,CORO1A,PDP1,MYBL1" Drug,7105_UP,"trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.49E-03,1.00E+00,4.68E-02,4.99E-01,8,173,"SSBP2,NR4A1,PLPPR4,SYT1,NR4A2,RGS4,CORO1A,SYNGR3" Drug,4617_UP,Thonzonium bromide [553-08-2]; Up 200; 6.8uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.49E-03,1.00E+00,4.68E-02,4.99E-01,8,173,"ETS2,NR4A1,NR4A2,LDLR,RGS4,TGIF1,EGR1,PATJ" Drug,CID000073670,clofentezine,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,4,40,"SMG6,MUS81,APEX1,MPZL2" Drug,CID000013086,ameltolide,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"ADM,AMIGO2" Drug,CID000521963,7-chloroquinoline,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"HTR1B,LDLR" Drug,CID000108030,A100 22,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"TSPO,HTR1B" Drug,CID000169064,AC1L5326,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"EGR1,EGR2" Drug,CID003037287,DU-18288,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"SST,HTR1B" Drug,ctd:C466858,ciguatoxin 3C,CTD,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"ARC,EGR1" Drug,ctd:C104705,dopamine quinone,CTD,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"PCSK1,PCSK2" Drug,CID000219090,fosaprepitant,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"TAC1,PART1" Drug,CID000091742,diethofencarb,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"UBR5,GPI" Drug,CID000154046,E-5842,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"BDNF,FGF2" Drug,CID011842604,3 g N,Stitch,1.50E-03,1.00E+00,4.68E-02,4.99E-01,2,5,"VWF,MX1" Drug,ctd:D004147,Dioxins,CTD,1.52E-03,1.00E+00,4.73E-02,5.04E-01,23,935,"ATP6V0C,CNKSR1,PSMC5,IER5,SLC25A25,STX1B,B4GALT6,BDNF,MDN1,CIAPIN1,DUSP4,DUSP6,KAT6A,APEX1,CCT2,LBR,PPAT,EDN1,IFRD1,MAP4K5,SERPINB1,ELF2,MPZL2" Drug,CID004478051,AC1NAJM8,Stitch,1.52E-03,1.00E+00,4.73E-02,5.04E-01,7,135,"ACOX1,PDYN,SST,ARC,FGF2,SYNM,LDLR" Drug,CID000657298,propylthiouracil,Stitch,1.52E-03,1.00E+00,4.73E-02,5.04E-01,7,135,"A1BG,NCL,TMEFF2,PTPRN,STRADA,LDLR,MPZL2" Drug,2084_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A",Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"SSBP2,PLPPR4,SYT1,DYRK3,PLSCR4,DUSP6,RGS4,CORO1A" Drug,1166_UP,17-AAG; Up 200; 1uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"WDR33,ACOX1,ISG20,PMP22,DUSP4,NR4A2,NR4A3,MICAL2" Drug,864_UP,geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"ISG20,RNF43,ADM,BBX,DYRK3,SYNM,RGS2,LDLR" Drug,972_UP,geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA,Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"ETV5,ISG20,ADM,CHPF,ZNF329,SHC1,RGS2,LDLR" Drug,7179_UP,"Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A",Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"SSBP2,ADM,DYRK3,NR4A2,RGS2,ARL4D,CORO1A,PDP1" Drug,2452_UP,Vigabatrin [60643-86-9]; Up 200; 31uM; HL60; HT_HG-U133A,Broad Institute CMAP Up,1.55E-03,1.00E+00,4.77E-02,5.08E-01,8,174,"MSC,ISG20,DUSP4,NR4A2,LAMB3,NR4A3,SP110,MX1" Drug,CID000010889,cetyl palmitate,Stitch,1.59E-03,1.00E+00,4.87E-02,5.19E-01,3,19,"CHGA,CHGB,SCG2" Drug,CID000020238,AC1L2FUA,Stitch,1.59E-03,1.00E+00,4.87E-02,5.19E-01,3,19,"PTPRN,SYNM,MX1" Drug,CID000099940,versicolorin A,Stitch,1.59E-03,1.00E+00,4.87E-02,5.19E-01,3,19,"TMEFF2,NR4A3,MYBL1" Drug,ctd:C034214,5-iodotubercidin,CTD,1.59E-03,1.00E+00,4.87E-02,5.19E-01,3,19,"CLK4,DYRK3,DYRK2" Drug,ctd:C002791,bismuth tripotassium dicitrate,CTD,1.59E-03,1.00E+00,4.87E-02,5.19E-01,7,136,"ITPKB,CEP170,PODXL,STMN1,EDN1,CORO1A,EGR1" Drug,4651_UP,Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; PC3; HT_HG-U133A,Broad Institute CMAP Up,1.61E-03,1.00E+00,4.90E-02,5.22E-01,8,175,"CLK4,ETS2,ADM,HES1,FOSB,EDN1,OVGP1,EGR1" Drug,2485_UP,"Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Up 200; 7.6uM; HL60; HT_HG-U133A",Broad Institute CMAP Up,1.61E-03,1.00E+00,4.90E-02,5.22E-01,8,175,"ISG20,DUSP4,NR4A2,LAMB3,NR4A3,FAM131A,FSTL1,MICAL2" Disease,C0009171,Cocaine Abuse,DisGeNET Curated,1.25E-06,6.62E-03,6.62E-03,6.06E-02,11,127,"PDYN,BDNF,ARC,FGF2,GCC1,HTR1B,FOSB,NR4A2,CRHBP,PRMT6,EGR1" Disease,C0038443,"Stress, Psychological",DisGeNET BeFree,3.32E-06,1.76E-02,7.62E-03,6.97E-02,13,199,"NCL,CHGA,BDNF,C1QL1,DST,TAC1,PLAT,NKTR,HTR1B,DUSP2,CRHBP,EDN1,CD59" Disease,C0236736,Cocaine-Related Disorders,DisGeNET Curated,4.30E-06,2.29E-02,7.62E-03,6.97E-02,10,117,"PDYN,BDNF,ARC,FGF2,GCC1,HTR1B,FOSB,CRHBP,PRMT6,EGR1" Disease,C0020538,Hypertensive disease,DisGeNET BeFree,9.18E-06,4.88E-02,1.22E-02,1.12E-01,50,1973,"PCSK1,MSC,LGR4,ETV5,ISG20,CHGA,CHGB,TNFRSF10B,NR4A1,SST,KCNIP3,BDNF,C1QL1,ADM,DST,COX5A,SLC35F3,SCG2,PXN,FGF2,SYT1,TAC1,PLAT,FHL2,TAP1,FOXF1,PART1,SEMA3F,GPI,HTR1B,VWF,PODXL,FOSB,ZNF652,DUSP2,SHC1,APEX1,NR4A3,FSD1,RGS2,LDLR,EDN1,RHO,CORO1A,FADS1,EGR1,MYLIP,CD59,SNAP25,MX1" Disease,C0085281,Addictive Behavior,DisGeNET BeFree,1.17E-05,6.23E-02,1.25E-02,1.14E-01,16,330,"PDYN,BDNF,C1QL1,TSPO,FGF2,SYT1,TAC1,NKTR,FOXF1,RAF1,FOSB,DUSP2,NR4A2,CRHBP,SNAP25,HCRTR2" Disease,C0600427,Cocaine Dependence,DisGeNET Curated,1.98E-05,1.05E-01,1.51E-02,1.38E-01,10,139,"PDYN,BDNF,ARC,FGF2,GCC1,HTR1B,FOSB,CRHBP,PRMT6,EGR1" Disease,C0524851,Neurodegenerative Disorders,DisGeNET BeFree,1.99E-05,1.06E-01,1.51E-02,1.38E-01,40,1480,"PCSK1,GJD2,MSC,FAM168B,ACOX1,PDYN,SERPINF1,NCL,ISG20,CHGA,NR4A1,SST,BDNF,ADM,METRN,COX5A,TSPO,SYT1,TAC1,PLAT,TAF1,TAP1,SMURF2,PMP22,DOCK2,FOSB,DUSP2,DUSP6,NR4A2,APEX1,STMN1,LDLR,EDN1,RHO,SYNGR3,MACF1,SNAP25,BBC3,NPAS4,RPPH1" Disease,C0006118,Brain Neoplasms,DisGeNET BeFree,2.58E-05,1.37E-01,1.53E-02,1.40E-01,30,980,"SOX4,SERPINF1,ETV5,CHGA,TNFRSF10B,SST,BDNF,ADM,LYVE1,ANOS1,TSPO,FGF2,SYT1,FHL2,PART1,SEMA3F,RAF1,FLT3LG,SYNM,DUSP2,ZNF329,APEX1,FSD1,LBR,TRIM3,RHO,ARL4D,EGR1,SPRY4,MACF1" Disease,C0007222,Cardiovascular Diseases,DisGeNET BeFree,2.59E-05,1.38E-01,1.53E-02,1.40E-01,41,1551,"GP6,SPRY2,SYNPO2,MSC,SERPINF1,ZNF385B,CHGA,CHGB,TNFRSF10B,KCNIP3,BDNF,C1QL1,ADM,COX5A,TSPO,FGF2,SYT1,TAC1,PLAT,FHL2,PMP22,PART1,FLT3LG,VWF,PODXL,FOSB,SHC1,NR4A2,APEX1,FSD1,RGS2,LDLR,EDN1,PRMT6,FADS1,FSTL1,LRIG1,EGR1,MYLIP,SNAP25,HCRTR2" Disease,C0494165,Secondary malignant neoplasm of liver,DisGeNET BeFree,3.81E-05,2.02E-01,1.88E-02,1.72E-01,29,951,"MSC,ACOX1,SERPINF1,NAB2,U2AF2,CHGA,CHGB,TNFRSF10B,SST,RNF43,TMEFF2,TSPO,PXN,FGF2,TAC1,AMIGO2,DYRK2,PMP22,SEMA3F,GPI,NPTX2,PODXL,DUSP6,NR4A2,LAMB3,FSD1,STMN1,FSTL1,RPPH1" Disease,C4551761,Excessive daytime sleepiness,DisGeNET BeFree,3.96E-05,2.10E-01,1.88E-02,1.72E-01,5,29,"BDNF,VWF,OPHN1,PATJ,HCRTR2" Disease,C2931822,Nasopharyngeal carcinoma,DisGeNET BeFree,4.76E-05,2.53E-01,1.88E-02,1.72E-01,39,1484,"SOX4,ZNF154,MAPKAPK2,SERPINF1,HLA-E,ZFAND5,NCL,ISG20,TNFRSF10B,SST,DST,COX5A,UBR5,TMPRSS3,TSPO,FGF2,SYT1,PLAT,HES1,TAP1,RAF1,HTR1B,FEZF2,FOSB,DUSP6,NR4A2,APEX1,NR4A3,FSD1,STMN1,LDLR,S1PR3,EDN1,FSTL1,LRIG1,EGR1,NIPAL1,RBM24,BBC3" Disease,C0220748,Cartilage-hair hypoplasia,DisGeNET BeFree,4.95E-05,2.63E-01,1.88E-02,1.72E-01,6,49,"SOX4,SPRY2,ANOS1,DUSP6,CORO1A,SPRY4" Disease,C0007785,Cerebral Infarction,DisGeNET BeFree,4.96E-05,2.63E-01,1.88E-02,1.72E-01,23,676,"PCSK1,GP6,SERPINF1,NR4A1,KCNIP3,BDNF,ADM,SCG2,TSPO,FGF2,PLAT,HES1,PART1,GPI,RAF1,VWF,FOSB,DUSP2,NR4A2,APEX1,LDLR,EDN1,NPAS4" Disease,C0424139,Anxiety and fear,DisGeNET BeFree,6.23E-05,3.31E-01,2.21E-02,2.02E-01,6,51,"SST,BDNF,C1QL1,TAC1,STMN1,RGS2" Disease,C0442874,Neuropathy,DisGeNET BeFree,9.28E-05,4.93E-01,3.06E-02,2.80E-01,18,477,"SOX4,RNF112,SST,BDNF,ADM,DST,TSPO,FGF2,TAC1,CNN3,PMP22,PART1,NPTX2,CHSY1,STMN1,EDN1,EGR2,SNAP25" Disease,C0030193,Pain,DisGeNET BeFree,9.80E-05,5.21E-01,3.06E-02,2.80E-01,38,1480,"MSC,ACOX1,PDYN,PSMC5,CHGA,TNFRSF10B,SST,KCNIP3,BDNF,ADM,DST,COX5A,SCG2,TSPO,ARC,SYT1,TAC1,PLAT,HES1,NKTR,PART1,GPI,SYNM,FOSB,DUSP2,APEX1,STMN1,LBR,RGS4,S1PR3,CRHBP,EDN1,NACC2,EGR1,SNAP25,MPZL2,NPAS4,HCRTR2" Disease,C0004936,Mental disorders,DisGeNET BeFree,1.15E-04,6.09E-01,3.34E-02,3.05E-01,24,763,"PDYN,SST,KCNIP3,BDNF,ADM,ANOS1,COX5A,PLPPR4,TSPO,FGF2,SYT1,PLAT,HES1,TMEM200C,HTR1B,FOSB,DUSP2,NR4A2,STMN1,RGS4,S1PR3,CRHBP,EGR1,SNAP25" Disease,C0155626,Acute myocardial infarction,DisGeNET BeFree,1.19E-04,6.34E-01,3.34E-02,3.05E-01,24,765,"GP6,MSC,MAPKAPK2,SERPINF1,TNFRSF10B,BDNF,C1QL1,ADM,COX5A,TSPO,SYT1,TAC1,PLAT,GPR3,VWF,GPR19,NR4A3,FSD1,LDLR,EDN1,FSTL1,EGR1,CD59,BBC3" Disease,C0149925,Small cell carcinoma of lung,DisGeNET BeFree,1.30E-04,6.90E-01,3.37E-02,3.08E-01,27,918,"PCSK1,SOX4,CENPF,PDYN,ISG20,CHGA,TNFRSF10B,SST,BDNF,C1QL1,ADM,PXN,FGF2,TAC1,HES1,TAP1,SEMA3F,RAF1,SYNM,LAMB3,NR4A3,CCT2,STMN1,FSTL1,EGR4,MACF1,SNAP25" Disease,C0007103,Malignant neoplasm of endometrium,DisGeNET BeFree,1.33E-04,7.08E-01,3.37E-02,3.08E-01,33,1231,"SOX4,ZNF154,SERPINF1,ETV5,NR4A1,SST,BDNF,TMEFF2,ADM,PTPRN,HYAL3,FGF2,SYT1,TAC1,PLAT,HES1,HS3ST2,PART1,SEMA3F,GPI,RAF1,HTR1B,FOSB,DUSP6,POT1,NTMT1,APEX1,FSD1,STMN1,EDN1,RIT1,FSTL1,EGR1" Disease,C3463824,MYELODYSPLASTIC SYNDROME,DisGeNET BeFree,1.45E-04,7.69E-01,3.37E-02,3.08E-01,28,975,"GP6,MSC,HLA-E,U2AF2,ISG20,CHGB,TNFRSF10B,NR4A1,BDNF,BBX,SYT1,HES1,FHL2,PART1,GPI,FLT3LG,HTR1B,NR4A2,APEX1,FSD1,STMN1,LDLR,RIT1,EGR1,CD59,FUT1,BBC3,PLK4" Disease,C0151744,Myocardial Ischemia,DisGeNET Curated,1.46E-04,7.74E-01,3.37E-02,3.08E-01,10,176,"NCL,NR4A1,FGF2,TAP1,DUSP6,PPAT,EDN1,EGR2,TLE4,MX1" Disease,C0009404,Colorectal Neoplasms,DisGeNET BeFree,1.59E-04,8.46E-01,3.53E-02,3.23E-01,20,589,"SERPINF1,U2AF2,TNFRSF10B,NR4A1,RNF43,ADM,UBR5,TSPO,PXN,HES1,PMP22,RAF1,RASA3,DUSP6,FSD1,LDLR,OPHN1,TGIF1,LRIG1,BBC3" Disease,C0007093,Carcinoid Heart Disease,DisGeNET BeFree,1.85E-04,9.80E-01,3.56E-02,3.26E-01,2,2,"CHGA,SST" Disease,C0004945,Bejel,DisGeNET BeFree,1.85E-04,9.80E-01,3.56E-02,3.26E-01,2,2,"PLAT,NR4A3" Disease,C3537179,Non-venereal endemic syphilis,DisGeNET BeFree,1.85E-04,9.80E-01,3.56E-02,3.26E-01,2,2,"PLAT,NR4A3" Disease,C0007787,Transient Ischemic Attack,DisGeNET BeFree,1.88E-04,9.98E-01,3.56E-02,3.26E-01,9,148,"PCSK1,MSC,SERPINF1,BDNF,PLAT,VWF,NR4A3,EDN1,BBC3" Disease,C0848548,hypertensive nephropathy,DisGeNET BeFree,2.46E-04,1.00E+00,4.50E-02,4.12E-01,5,42,"CHGA,NR4A1,BASP1,FHL2,SMURF2" Disease,C1332206,Adult Lymphoma,DisGeNET BeFree,2.61E-04,1.00E+00,4.60E-02,4.21E-01,31,1169,"SPRY2,ACOX1,SERPINF1,ETV5,ISG20,CHGA,TNFRSF10B,NR4A1,SST,ADM,COX5A,UBR5,HS3ST2,PLSCR4,PART1,GPI,RAF1,VWF,FOSB,KAT6A,APEX1,NR4A3,STMN1,LBR,RIT1,CORO1A,EGR1,TLE4,CD59,SNAP25,PLK4" Disease,C1332979,Childhood Lymphoma,DisGeNET BeFree,2.69E-04,1.00E+00,4.60E-02,4.21E-01,31,1171,"SPRY2,ACOX1,SERPINF1,ETV5,ISG20,CHGA,TNFRSF10B,NR4A1,SST,ADM,COX5A,UBR5,HS3ST2,PLSCR4,PART1,GPI,RAF1,VWF,FOSB,KAT6A,APEX1,NR4A3,STMN1,LBR,RIT1,CORO1A,EGR1,TLE4,CD59,SNAP25,PLK4"