Compound number,SMILES,T. b. brucei pIC50,T. b. rhodesiense  pIC50,MRC-5 pIC50,T. cruzi pIC50 ,L. infantum pIC50,PMM pIC50
2,O=C1C(NN=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,7.2 ± 0.2,N.D.,<4.2,<4.2,<4.2,<4.2
7,O=C1C2=NNC(C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1C,<5.0,,<4.2,,,
11,O=C1C(N(C)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,7.1 ± 0.1,,<4.2,,,
15,O=C1C2=NN(C)C(C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,5.8 ± 0.1,,<4.2,,,
17,N=C1C(NN=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,<5.0,,4.6 ± 0.0,,,
21a,O=C1C(N(CC)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,6.6 ± 0.4,,<4.2,,,
21b,O=C1C(N(CCC)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,6.8 ± 0.2,,<4.2,,,
21c,O=C1C(N(C(C)C)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,5.2 ± 0.1,,<4.2,,,
21d,O=C1C(N(CCOC)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,<4.2,,<4.2,,,
21e,O=C1C(N(CCC2=CC=C(OC)C=C2)N=C3C(C)C)=C3N=C(C4=CC=C(F)C=C4)N1,5.5 ± 0.3,,<4.2,,,
21f,O=C(N)CCN1N=C(C(C)C)C(N=C(C2=CC=C(F)C=C2)N3)=C1C3=O,<4.2,,<4.2,,,
22,O=C1C(N(CCO)N=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,6.2 ± 0.1,,<4.2,,,
31a,O=C1C(NN=C2C3CCCC3)=C2N=C(C4=CC=C(F)C=C4)N1,8.0 ± 0.0,8.0 ± 0.0,<4.2,<4.2,<4.2,<4.2
31b,O=C1C(NN=C2C3CCCCC3)=C2N=C(C4=CC=C(F)C=C4)N1,7.4 ± 0.0,,<4.2,,,
31c,O=C1C(NN=C2C(C)(C)C)=C2N=C(C3=CC=C(F)C=C3)N1,7.8 ± 0.3,8.0 ± 0.0,<4.2,<4.2,<4.2,<4.2
31d,O=C1C(NN=C2CC)=C2N=C(C3=CC=C(F)C=C3)N1,6.4 ± 0.0,,<4.2,,,
31e,O=C1C(NN=C2C)=C2N=C(C3=CC=C(F)C=C3)N1,4.6 ± 0.4,,<4.2,,,
31f,O=C1C(NN=C2)=C2N=C(C3=CC=C(F)C=C3)N1.O=CO,<4.2,,<4.2,,,
35,O=C1C(NN=C2C3=CC=CC=C3)=C2N=C(C4=CC=C(F)C=C4)N1,7.3 ± 0.1,,<4.2,,,