Species,Time.q,age_yrs.q,IBD.q,logistic.Time,logistic.age_yrs,logistic.IBD,beta.Time,beta.age_yrs,beta.IBD,lme.Time,lme.age_yrs,lme.IBD Actinobacteria Bifidobacterium longum,0.286994382,0.891992147,0.065988955,0.616165275,-1.634714032,-41.40880792,0.028002893,-0.020089768,-0.025960637,,, Actinobacteria Bifidobacterium pseudocatenulatum,0.286994382,0.80986424,0.061361927,0.271723754,-0.065151927,-5.342100147,0.03688806,-0.04530978,0.376273295,,, Actinobacteria Collinsella aerofaciens,0.473607595,0.933653005,0.076657784,-0.118582481,0.232731798,-22.00597146,0.02211715,-0.011523216,-0.469328035,,, Actinobacteria Eggerthella unclassified,0.935615213,0.933653005,0.170223245,0.066751814,0.04066738,0.861028869,-0.009329442,-0.015338855,0.356541048,,, Bacteroidetes Alistipes finegoldii,1,0.80986424,0.006106631,-0.070383646,0.216091041,-10.941581,-0.015568251,0.045734804,-0.744302015,,, Bacteroidetes Alistipes indistinctus,1,0.748760586,1,-0.22147369,0.934604374,-5.431381725,0.001587083,0.022642371,-0.529152756,,, Bacteroidetes Alistipes onderdonkii,0.935615213,0.933653005,0.001508914,-0.004578262,0.219390617,-102.0948386,-0.014198797,0.016869386,-0.463549013,,, Bacteroidetes Alistipes putredinis,0.579789146,0.467279374,0.002020121,-0.19834085,-5.703338785,-67.43118846,-0.012043258,-0.046207286,-0.126253595,,, Bacteroidetes Alistipes shahii,1,0.467279374,0.19023669,-0.059878681,-0.735456281,-7.978934563,-0.002557214,0.019483741,-0.721877297,,, Bacteroidetes Bacteroides caccae,0.935615213,0.467279374,0.047656313,0.134434289,-0.649795769,-2.48609505,-0.008424206,-0.083447134,1.006628509,,, Bacteroidetes Bacteroides cellulosilyticus,0.579789146,0.026949909,0.001508914,-0.296761309,-0.356315726,-1.131472177,0.017932287,0.031005118,-0.665250868,,, Bacteroidetes Bacteroides dorei,0.473607595,0.910260758,0.838912455,-0.099398684,0.459174616,-0.456053493,-0.041522291,0.053223329,0.149577132,,, Bacteroidetes Bacteroides faecis,0.410475001,0.298553029,0.001508914,0.126293214,-0.089286046,-7.092564123,0.076755152,-0.09274944,1.037550292,,, Bacteroidetes Bacteroides fragilis,0.954534893,0.980328221,0.040979142,0.001286129,-0.057981151,-6.63115503,-0.017903052,0.009507047,0.50253266,,, Bacteroidetes Bacteroides massiliensis,1,0.298553029,0.529902633,-0.031406594,1.500107231,-8.81960948,-0.043648208,0.179797516,-0.422651027,,, Bacteroidetes Bacteroides ovatus,0.017577935,0.586271254,0.036114542,0.018932223,-0.916873517,-158.9574551,0.057428003,-0.060212064,0.730490996,,, Bacteroidetes Bacteroides stercoris,0.935615213,0.80986424,0.097871938,0.161192571,-0.008822667,15.43055507,0.001681014,0.073727862,-0.592235863,,, Bacteroidetes Bacteroides thetaiotaomicron,0.756177039,0.80986424,0.141479084,-0.070484224,-0.148967862,-20.80217711,-0.029880104,-0.059456917,0.316399261,,, Bacteroidetes Bacteroides uniformis,0.470611668,0.764630261,0.34245631,0.179190958,0.593144517,2.347590894,0.019203677,-0.009226613,-0.139114665,,, Bacteroidetes Bacteroides vulgatus,0.500503791,0.764630261,1,-0.403111765,-0.972677016,-3.996743628,-0.012309407,0.032646729,0.346612133,,, Bacteroidetes Bacteroides xylanisolvens,0.935615213,0.06045283,0.036114542,0.039950158,1.040881944,-8.242415419,0.01697824,-0.08568687,0.326679332,,, Bacteroidetes Barnesiella intestinihominis,0.673712371,0.82880195,0.316650739,-0.120892757,-0.087451706,-15.88533466,-0.015014434,-0.05880467,-0.257516539,,, Bacteroidetes Odoribacter splanchnicus,0.286994382,0.764630261,0.026346466,-0.027629528,-0.244613019,-1.201000855,-0.056241704,-0.013624678,0.727948393,,, Bacteroidetes Parabacteroides distasonis,0.861713093,0.746038304,0.348406162,-0.181376075,-0.558158746,-7.261402062,-0.012742932,-0.083897256,-0.067302809,,, Bacteroidetes Parabacteroides merdae,0.935615213,0.891992147,0.614918695,-0.108206361,0.131238268,0.105817788,-0.009298977,-0.030225658,-0.324005495,,, Bacteroidetes Parabacteroides unclassified,0.673712371,0.80986424,0.467046583,0.065860926,-0.339434505,1.650203337,0.048597946,0.014581275,0.323969156,,, Bacteroidetes Porphyromonas asaccharolytica,0.935615213,0.933653005,0.771015721,0.013240056,-0.035764793,-0.124674079,-0.033700052,-0.017606029,0.230392114,,, Firmicutes Anaerostipes hadrus,1,1,0.045683235,-0.032794215,0.298344297,-6.243983156,-0.018588468,-0.004454394,0.109166322,,, Firmicutes Anaerotruncus colihominis,0.935615213,0.746038304,0.734419727,,,,,,,8.71782E-05,-0.000778866,-0.00167621 Firmicutes Anaerotruncus unclassified,0.922374651,0.80986424,0.038977331,,,,,,,-0.000218694,0.000296806,-0.006680935 Firmicutes Clostridiaceae bacterium JC118,0.935615213,0.746038304,0.862764349,-0.051374873,-0.131914655,0.276327674,0.016674588,0.056996471,0.12102479,,, Firmicutes Clostridiales bacterium 1 7 47FAA,1,0.933653005,0.316650739,-0.011928214,-0.026014915,0.463113844,0.006907984,-0.014205312,0.301629027,,, Firmicutes Clostridium asparagiforme,0.935615213,0.933653005,0.131882875,-0.036503746,-7.05284E-05,-1.077112147,0.019106307,-0.020156286,0.326397786,,, Firmicutes Clostridium bartlettii,0.935615213,0.933653005,0.083278699,0.032331484,-0.020550399,-1.961050868,0.02357804,-0.016983471,-0.096820417,,, Firmicutes Clostridium bolteae,1,0.80986424,0.119763555,0.002787771,-0.135391673,-0.819499088,0.003295438,-0.023011617,0.356310569,,, Firmicutes Clostridium citroniae,0.340221151,0.762502888,0.801494965,,,,,,,-0.000496277,-0.000396856,0.000652445 Firmicutes Clostridium hathewayi,0.861713093,0.80986424,0.773797165,0.077230555,-0.081521063,-0.393522748,-0.016867033,0.017656529,0.064269949,,, Firmicutes Clostridium leptum,0.935615213,0.80986424,0.006106631,0.024903471,-0.001824883,-2.192432686,0.026052569,-0.051030129,-0.085052722,,, Firmicutes Clostridium nexile,0.935615213,0.80986424,0.767388657,0.002127911,-0.102370724,0.643561114,-0.032982483,0.0368177,-0.155610992,,, Firmicutes Clostridium symbiosum,0.935615213,0.762502888,0.051982063,-0.061656036,-0.212792597,0.373115046,-0.01796417,-0.002536196,0.508043732,,, Firmicutes Coprococcus catus,0.673712371,0.746038304,0.001508914,-0.267807591,1.206377988,-14.53151699,5.61302E-05,0.028333739,-0.606488087,,, Firmicutes Coprococcus comes,1,0.80986424,0.299485632,-1.365510502,5.493603293,-136.7401514,-0.001696693,0.038428279,0.086422967,,, Firmicutes Dialister invisus,0.922374651,0.586271254,0.316650739,0.124755694,-0.601202531,3.478472728,0.001497401,-0.029227763,-0.185365319,,, Firmicutes Dorea formicigenerans,0.473607595,0.80986424,0.158684586,-0.101573826,0.187285363,-20.38423121,0.00158224,0.000338093,0.109804913,,, Firmicutes Dorea longicatena,1,0.82880195,0.122537626,0.047716782,0.232951678,-36.78953938,0.00389894,0.031452332,-0.173185389,,, Firmicutes Erysipelotrichaceae bacterium 6 1 45,0.922374651,0.80986424,0.456212967,0.079273498,-0.127223033,-1.090995742,-0.000449344,0.022393266,-0.076812105,,, Firmicutes Eubacterium eligens,0.935615213,0.80986424,0.000480309,-0.009890427,0.476799652,-14.60209726,0.00189811,-0.003937834,0.519887009,,, Firmicutes Eubacterium hallii,0.935615213,0.467279374,3.43634E-05,0.065582621,0.544004045,-30.53767313,0.012096586,0.042691952,-0.586308307,,, Firmicutes Eubacterium ramulus,0.935615213,0.80986424,0.373602447,,,,,,,9.42534E-05,0.000668366,-0.006081271 Firmicutes Eubacterium rectale,0.861713093,0.746038304,0.001482979,0.123853512,-0.219644686,-6.323614953,0.011066641,0.061714874,-0.586606651,,, Firmicutes Eubacterium siraeum,0.922374651,0.979382693,0.001308226,0.105604227,-0.070992475,-6.00003227,2.91946E-05,-0.012851152,0.02809348,,, Firmicutes Eubacterium sp 3 1 31,0.935615213,0.891992147,0.102154823,0.075313738,-0.070814953,16.13853492,0.020554593,0.034083445,0.112970693,,, Firmicutes Eubacterium ventriosum,0.935615213,0.467279374,0.038977331,0.104703721,-0.075804484,-37.6730365,-0.002899575,-0.04093446,0.012521676,,, Firmicutes Faecalibacterium prausnitzii,0.286994382,0.997415207,0.193612186,727.7787222,-896.0603756,-18725.02858,-0.007723932,-0.009864894,0.093655517,,, Firmicutes Flavonifractor plautii,1,0.979382693,0.34245631,0.017361119,-0.052085076,0.243098928,0.000571667,-0.002603572,0.396582193,,, Firmicutes Holdemania filiformis,0.954534893,0.864969439,0.628743808,,,,,,,7.95657E-05,0.000301088,0.00227566 Firmicutes Holdemania unclassified,0.935615213,0.80986424,0.034679445,,,,,,,-7.51382E-05,-0.000250817,-0.005523987 Firmicutes Lachnospiraceae bacterium 1 1 57FAA,0.935615213,0.933653005,0.769328082,0.043684553,-0.006025964,-0.494712254,0.019961768,-0.030890038,0.1538229,,, Firmicutes Lachnospiraceae bacterium 1 4 56FAA,0.286994382,0.80986424,0.545865877,,,,,,,0.00046967,0.000324915,0.001888942 Firmicutes Lachnospiraceae bacterium 2 1 58FAA,0.935615213,0.997415207,0.713821133,0.056484186,0.032921093,0.943650212,0.01101503,0.007656685,-0.0715285,,, Firmicutes Lachnospiraceae bacterium 3 1 46FAA,0.87289993,0.80986424,0.376851733,-0.048911671,-0.06399267,-1.556209009,0.014986164,0.022229981,0.318777488,,, Firmicutes Lachnospiraceae bacterium 3 1 57FAA CT1,0.470611668,0.891992147,0.308769074,-0.077020165,-0.085545453,-0.673247567,0.056098177,-0.00868117,0.350227372,,, Firmicutes Lachnospiraceae bacterium 5 1 63FAA,0.856652914,0.979382693,0.045683235,-0.155689185,0.048178825,-10.16012892,0.020320633,-0.025147509,0.079170785,,, Firmicutes Lachnospiraceae bacterium 7 1 58FAA,0.856652914,0.891992147,0.599890833,,,,,,,-0.000276716,-0.000293576,-0.003068164 Firmicutes Lachnospiraceae bacterium 8 1 57FAA,0.922374651,0.80986424,0.038977331,0.039659265,0.05205776,-0.980101259,0.032808078,0.02224259,-0.348018726,,, Firmicutes Oscillibacter unclassified,1,1,0.299485632,0.124578051,0.201659639,-4.41096377,-0.018172114,0.011784436,-0.308488719,,, Firmicutes Peptostreptococcaceae noname unclassified,0.286994382,0.746038304,0.315207439,0.136277732,-0.101979388,-0.95997014,-0.029428615,-0.04305441,0.001565258,,, Firmicutes Roseburia hominis,0.856652914,0.746038304,0.0150002,0.080564382,0.166081558,-5.243094723,0.031801988,0.01072522,-0.395795148,,, Firmicutes Roseburia intestinalis,0.902149285,0.80986424,0.112900784,0.065917236,0.035926655,-2.915037232,0.033265239,-0.039481274,0.154935508,,, Firmicutes Roseburia inulinivorans,0.500503791,0.80986424,0.348406162,0.094807894,-0.201611545,-2.077074424,0.039824533,0.026480506,0.066702656,,, Firmicutes Roseburia unclassified,0.944456041,0.891992147,0.771015721,-0.095224696,-0.026352127,0.383342765,-0.038050738,0.035023493,0.533167875,,, Firmicutes Ruminococcus gnavus,0.935615213,0.880578988,0.016305689,-0.046066445,-0.151478992,2.991998747,-0.022967062,0.016313153,0.58471707,,, Firmicutes Ruminococcus lactaris,0.550344202,0.933653005,0.045683235,-0.150526889,0.321827123,-38.96333322,-0.040505302,-0.017083721,0.596309799,,, Firmicutes Ruminococcus obeum,0.935615213,0.584179614,0.001308226,0.098159387,0.627799525,-29.94070586,0.006247047,0.021326213,-0.529306245,,, Firmicutes Ruminococcus sp 5 1 39BFAA,1,0.821305146,0.015024112,0.015318874,0.167107662,-3.317675428,-0.009998457,-0.008876743,0.219734905,,, Firmicutes Ruminococcus torques,0.935615213,0.80986424,0.50885488,,,,,,,-0.00056422,0.002066907,0.011627092 Firmicutes Streptococcus parasanguinis,0.550344202,0.80986424,0.511989012,0.072023168,0.095800572,-0.440492172,0.04709709,0.032221899,0.210659503,,, Firmicutes Streptococcus salivarius,0.902149285,0.586271254,0.193612186,0.06346626,-0.085625054,-1.111826827,0.023410315,0.046057982,-0.081091682,,, Firmicutes Streptococcus thermophilus,1,0.933653005,0.948816023,-4.88898E-06,0.000241168,0.176340771,0.008293784,-0.020125738,0.049681882,,, Firmicutes Subdoligranulum unclassified,0.922374651,0.80986424,7.66346E-05,0.058980256,0.373385244,-25.61066759,-0.018664128,0.013411379,-1.02488858,,, Firmicutes Veillonella atypica,0.935615213,0.825901279,0.135816719,0.06835198,-0.12287352,1.445390584,-0.001065497,-0.03044819,0.631393565,,, Firmicutes Veillonella parvula,1,0.80986424,0.108211268,0.015878244,-0.144403262,0.759359462,-0.006825161,-0.008888136,0.452491045,,, Firmicutes Veillonella unclassified,1,0.979382693,0.265801716,-0.013903427,-0.041508569,-0.214768943,0.007696122,-0.004653251,0.366777931,,, Proteobacteria Bilophila unclassified,0.313321824,0.979382693,0.016305689,0.014314291,-0.715677336,-16.26534522,-0.041602101,-0.007461827,0.25345576,,, Proteobacteria Bilophila wadsworthia,0.473607595,0.80986424,0.376851733,,,,,,,-0.000434816,-0.000520306,0.003983318 Proteobacteria Burkholderiales bacterium 1 1 47,0.286994382,1,0.044921867,-0.166124808,0.061723571,-11.86361204,-0.024976863,-0.020713282,0.196639063,,, Proteobacteria Escherichia coli,0.935615213,0.80986424,0.034260372,-0.028839338,-0.079204035,0.802932116,-0.018351846,-0.025226373,0.56512885,,, Proteobacteria Escherichia unclassified,1,0.891992147,0.614918695,0.016098527,0.045831617,0.066516688,0.013407529,-0.003347147,0.253947927,,, Proteobacteria Haemophilus parainfluenzae,0.935615213,0.467279374,0.34245631,-0.033939172,-0.232736037,0.439610229,0.016734642,0.024464026,0.328950774,,, Proteobacteria Parasutterella excrementihominis,0.375668569,0.586271254,0.003602633,-0.183393527,0.150115142,-43.39413422,-0.01578047,0.042958796,-0.326234244,,, Verrucomicrobia Akkermansia muciniphila,0.902149285,0.80986424,0.015024112,-0.108310461,0.132426119,-38.14872876,-0.003143924,0.041784411,0.000237255,,, ,,,,,,,,,,,, ,,,,,,,,,,,, ,,,,,,,,,,,, ,,,,,,,,,,,, "If the taxa has less than 10 zeros or the maximum abundance is too small, the ZIBR test may not be accurate so we used the results of the linear mixed effect model as suggested.",,,,,,,,,,,,