#GeneID,Symbol,GeneInfo,Localization,Process,Function,# elements 1,casTLE Effect 1,casTLE Score 1,# elements 2,casTLE Effect 2,casTLE Score 2,Combo casTLE Effect,Combo casTLE Score,casTLE p-value,Minimum Effect Estimate,Maximum Effect Estimate
ENSMUSG00000018921,PELP1,"proline, glutamate and leucine rich protein 1",nucleus|nucleolus|cytoplasm|membrane|MLL1 complex|,"transcription, DNA-templated|",protein binding|poly(A) RNA binding|,7,-4.6,10.8,7,-5.9,32.7,-4.9,42.6,2.00E-05,-8.6,-3
ENSMUSG00000047407,TGIF1,TGFB-induced factor homeobox 1,nucleoplasm|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|neural tube closure|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|multicellular organismal development|determination of left/right symmetry|negative regulation of cell proliferation|dorsal/ventral pattern formation|gene expression|regulation of gastrulation|nodal signaling pathway|response to drug|positive regulation of neuron differentiation|positive regulation of fibroblast proliferation|negative regulation of retinoic acid receptor signaling pathway|retina development in camera-type eye|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|co-SMAD binding|,10,-6.9,31.9,10,-2.6,1.12,-6.7,31,6.00E-05,-10,-4.2
ENSMUSG00000039396,NEIL3,nei endonuclease VIII-like 3 (E. coli),nucleus|,"DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|base-excision repair|nucleotide-excision repair|",bubble DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|zinc ion binding|DNA N-glycosylase activity|,9,4,1.84,10,-5.6,30.7,-5.3,30.1,6.00E-05,-10.2,-2.1
ENSMUSG00000022674,UBE2V2,ubiquitin-conjugating enzyme E2 variant 2,nucleus|cytoplasm|UBC13-MMS2 complex|extracellular vesicular exosome|,protein polyubiquitination|DNA double-strand break processing|regulation of DNA repair|cell proliferation|positive regulation of neuron projection development|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of neuron apoptotic process|positive regulation of DNA repair|positive regulation of synapse assembly|,protein binding|acid-amino acid ligase activity|,9,-4.9,19.4,9,-3.5,8.71,-4.2,26.7,0.00014,-6.5,-2.7
ENSMUSG00000026355,MCM6,minichromosome maintenance complex component 6,nucleus|nucleus|nucleoplasm|MCM complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|,single-stranded DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|identical protein binding|,6,0.8,0.429,7,7.8,28.4,7.7,26,0.00016,1.9,13.5
ENSMUSG00000056234,NCOA4,nuclear receptor coactivator 4,nucleus|,"transcription, DNA-templated|male gonad development|response to hormone|androgen receptor signaling pathway|positive regulation of transcription, DNA-templated|",transcription coactivator activity|androgen receptor binding|,10,-4,8.15,10,-5.4,18.6,-4.3,25.9,0.00016,-7.9,-1.9
ENSMUSG00000027263,TUBGCP4,"tubulin, gamma complex associated protein 4",spindle pole|centrosome|cytosol|microtubule|gamma-tubulin ring complex|microtubule cytoskeleton|membrane|,G2/M transition of mitotic cell cycle|mitotic cell cycle|protein complex assembly|microtubule nucleation|,structural constituent of cytoskeleton|,6,-3.2,4.22,6,7.8,27.1,7.6,25.8,0.00016,2.1,13.7
ENSMUSG00000024844,BANF1,barrier to autointegration factor 1,nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|extracellular vesicular exosome|,mitotic cell cycle|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|response to virus|DNA integration|viral process|establishment of integrated proviral latency|,DNA binding|protein binding|,10,-4.9,11.5,10,-3.7,15,-4.7,25.4,0.00016,-6.5,-2.8
ENSMUSG00000015697,SETDB1,"SET domain, bifurcated 1",nucleus|chromosome|cytoplasm|Golgi apparatus|plasma membrane|,"inner cell mass cell proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|histone lysine methylation|bone development|",DNA binding|protein binding|zinc ion binding|histone-lysine N-methyltransferase activity|,10,-5.4,21.4,9,-2.4,6.1,-4.4,24.9,0.00016,-7.9,-2.6
ENSMUSG00000030062,RPN1,ribophorin I,endoplasmic reticulum membrane|endoplasmic reticulum membrane|rough endoplasmic reticulum|oligosaccharyltransferase complex|membrane|integral component of membrane|melanosome|,translation|cellular protein modification process|SRP-dependent cotranslational protein targeting to membrane|gene expression|protein N-linked glycosylation via asparagine|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|poly(A) RNA binding|,9,-4.1,9.55,8,-5,15.5,-4.3,24.5,0.00018,-8.2,-2.7
ENSMUSG00000018841,RAD51D,RAD51 paralog D,"chromosome, telomeric region|nucleus|replication fork|cytoplasm|centrosome|Rad51B-Rad51C-Rad51D-XRCC2 complex|",telomere maintenance|double-strand break repair via homologous recombination|ATP catabolic process|ATP catabolic process|DNA repair|reciprocal meiotic recombination|strand invasion|,four-way junction DNA binding|DNA binding|single-stranded DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|gamma-tubulin binding|,10,-4.6,12.7,10,-3,12.8,-3.7,23.9,0.00024,-5.8,-2.2
ENSMUSG00000014355,ANAPC1,anaphase promoting complex subunit 1,nucleoplasm|anaphase-promoting complex|cytosol|,mitotic cell cycle|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,None,10,-3.6,8.57,8,-3.8,14.8,-3.7,22.9,0.00034,-5.9,-2.3
ENSMUSG00000030884,UQCRC2,ubiquinol-cytochrome c reductase core protein II,mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|extracellular vesicular exosome|,oxidative phosphorylation|proteolysis|aerobic respiration|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|,metalloendopeptidase activity|protein binding|protein complex binding|metal ion binding|,9,-2.2,4.2,10,-3.9,18.2,-3.7,21.3,0.0007,-6.1,-2
ENSMUSG00000020471,POLD2,"polymerase (DNA directed), delta 2, accessory subunit",nucleus|nucleoplasm|delta DNA polymerase complex|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|",DNA binding|DNA-directed DNA polymerase activity|protein binding|,3,-5.3,7.46,5,8,23.1,8,21.1,0.00076,5,16
ENSMUSG00000009013,DYNLL1,"dynein, light chain, LC8-type 1",kinetochore|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|COP9 signalosome|membrane|extracellular vesicular exosome|mitotic spindle|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|transcription, DNA-templated|regulation of transcription, DNA-templated|transport|apoptotic process|microtubule-based process|female gamete generation|anatomical structure morphogenesis|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|substantia nigra development|actin cytoskeleton organization|negative regulation of phosphorylation|regulation of catalytic activity|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|",motor activity|protein binding|protein C-terminus binding|enzyme binding|protein domain specific binding|nitric-oxide synthase regulator activity|protein homodimerization activity|,10,-4.2,13.9,8,-3,7.8,-4,21.1,0.00076,-6.1,-2.3
ENSMUSG00000025234,ARIH1,ariadne RBR E3 ubiquitin protein ligase 1,ubiquitin ligase complex|cytoplasm|cytosol|,ubiquitin-dependent protein catabolic process|protein ubiquitination|protein ubiquitination|cytokine-mediated signaling pathway|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|small conjugating protein ligase activity|ubiquitin protein ligase binding|,10,-4.7,8.85,10,-3.2,14.1,-3.9,20.9,0.00084,-5.9,-2.1
ENSMUSG00000029833,TRIM24,tripartite motif containing 24,nucleus|nuclear euchromatin|perichromatin fibrils|cytosol|,"transcription from RNA polymerase II promoter|negative regulation of cell proliferation|protein ubiquitination|protein ubiquitination|protein catabolic process|regulation of protein stability|regulation of apoptotic process|response to peptide hormone|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|calcium ion homeostasis|regulation of vitamin D receptor signaling pathway|cellular response to estrogen stimulus|regulation of signal transduction by p53 class mediator|",p53 binding|chromatin binding|transcription coactivator activity|protein kinase activity|ubiquitin-protein transferase activity|receptor binding|protein binding|zinc ion binding|ligase activity|ligand-dependent nuclear receptor binding|estrogen response element binding|sequence-specific DNA binding|lysine-acetylated histone binding|,10,-2.1,0.949,10,-6.5,21.2,-5.3,20.3,0.00098,-11.5,-2
ENSMUSG00000002068,CCNE1,cyclin E1,cyclin-dependent protein kinase holoenzyme complex|nucleus|nucleoplasm|cytosol|,"regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication initiation|protein phosphorylation|Wnt signaling pathway|androgen receptor signaling pathway|positive regulation of transcription, DNA-templated|cell division|",transcription coactivator activity|protein binding|kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|androgen receptor binding|,10,-5.2,12.8,10,-3.3,8.2,-4.7,19.8,0.00116,-7.7,-2.6
ENSMUSG00000050732,VAMP8,vesicle-associated membrane protein 8,mitochondrion|lysosomal membrane|early endosome|plasma membrane|membrane|integral component of membrane|secretory granule membrane|SNARE complex|late endosome membrane|recycling endosome|extracellular vesicular exosome|,autophagic vacuole fusion|protein complex assembly|post-Golgi vesicle-mediated transport|vesicle fusion|protein transport|regulation of endocytosis|viral entry into host cell|membrane organization|,syntaxin binding|,10,-3,5.56,10,-6.4,16,-2.4,19.6,0.00126,-8.5,-1.2
ENSMUSG00000032087,DSCAML1,Down syndrome cell adhesion molecule like 1,extracellular space|plasma membrane|cell surface|integral component of membrane|,cell fate determination|homophilic cell adhesion|negative regulation of cell adhesion|axonogenesis|central nervous system development|brain development|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|dendrite self-avoidance|,protein homodimerization activity|,10,-3.5,1.45,10,-6.6,18.9,-5.4,19.6,0.00126,-10.8,-1.4
ENSMUSG00000014769,PSMB1,"proteasome (prosome, macropain) subunit, beta type, 1",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome core complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",threonine-type endopeptidase activity|protein binding|,7,-3.9,6.42,6,-3.8,13.5,-3.8,19.5,0.00132,-6.4,-2.1
ENSMUSG00000000759,TUBGCP3,"tubulin, gamma complex associated protein 3",cytoplasm|centrosome|centrosome|centriole|spindle|polar microtubule|cytosol|membrane|,G2/M transition of mitotic cell cycle|mitotic cell cycle|microtubule nucleation|single fertilization|,structural molecule activity|structural constituent of cytoskeleton|protein binding|gamma-tubulin binding|,9,-1.6,0.815,9,-6.6,20.4,-2.2,19.3,0.0014,-11,-1.2
ENSMUSG00000002307,DAXX,death-domain associated protein,"chromosome, centromeric region|heterochromatin|nucleus|nucleus|nucleolus|cytoplasm|cytosol|PML body|PML body|SWI/SNF superfamily-type complex|","mitotic cytokinesis|positive regulation of protein phosphorylation|nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|activation of JUN kinase activity|extrinsic apoptotic signaling pathway via death domain receptors|viral process|androgen receptor signaling pathway|regulation of protein ubiquitination|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of neuron death|positive regulation of apoptotic signaling pathway|",p53 binding|transcription corepressor activity|receptor signaling protein activity|protein binding|transcription factor binding|enzyme binding|protein kinase binding|protein kinase activator activity|heat shock protein binding|ubiquitin protein ligase binding|histone binding|protein homodimerization activity|protein N-terminus binding|androgen receptor binding|,10,-5,18.1,10,-1.7,4.07,-4.8,19,0.00152,-7.4,-2.6
ENSMUSG00000038943,PRC1,protein regulator of cytokinesis 1,spindle pole|nucleus|cytoplasm|spindle|spindle microtubule|plasma membrane|microtubule cytoskeleton|,mitotic spindle elongation|cytokinesis|,protein binding|microtubule binding|protein kinase binding|identical protein binding|,10,-5.1,11,7,-3.6,8.94,-4.5,18.9,0.00152,-7.1,-2.4
ENSMUSG00000046711,HMGA1,high mobility group AT-hook 1,nucleus|nucleoplasm|transcription factor complex|cytosol|senescence-associated heterochromatin focus|,"DNA catabolic process, endonucleolytic|DNA unwinding involved in DNA replication|base-excision repair|nucleosome disassembly|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|negative regulation of cell proliferation|response to virus|viral process|negative regulation of chromatin silencing|senescence-associated heterochromatin focus assembly|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|establishment of integrated proviral latency|oncogene-induced cell senescence|positive regulation of cellular senescence|",DNA binding|AT DNA binding|sequence-specific DNA binding transcription factor activity|DNA-(apurinic or apyrimidinic site) lyase activity|protein binding|transcription factor binding|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|retinoid X receptor binding|5'-deoxyribose-5-phosphate lyase activity|,10,-3.2,7.02,10,-3.6,12.2,-3.3,18.7,0.00158,-5.6,-1.9
ENSMUSG00000029649,POMP,proteasome maturation protein,proteasome complex|nucleus|endoplasmic reticulum|cytosol|organelle membrane|,proteasome assembly|,protein binding|,9,-4.3,12.6,5,8,22,8,18.6,0.00162,-4.3,16
ENSMUSG00000011960,CCNT1,cyclin T1,nucleus|nucleoplasm|positive transcription elongation factor complex b|,"regulation of cyclin-dependent protein serine/threonine kinase activity|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein phosphorylation|cell cycle|transforming growth factor beta receptor signaling pathway|gene expression|viral process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|cell division|",DNA binding|chromatin binding|protein binding|snRNA binding|protein kinase binding|transcription regulatory region DNA binding|,10,-5.9,11.3,10,-4.3,7.81,-5.8,18.4,0.00186,-8.7,-3.1
ENSMUSG00000005566,TRIM28,tripartite motif containing 28,nucleus|nucleus|nucleoplasm|nuclear euchromatin|nuclear heterochromatin|,"negative regulation of transcription from RNA polymerase II promoter|epithelial to mesenchymal transition|DNA repair|transcription initiation from RNA polymerase II promoter|gene expression|protein ubiquitination|protein sumoylation|protein sumoylation|positive regulation of transcription factor import into nucleus|innate immune response|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein oligomerization|convergent extension involved in axis elongation|embryonic placenta morphogenesis|negative regulation of viral release from host cell|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein kinase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|ubiquitin protein ligase binding|Krueppel-associated box domain binding|sequence-specific DNA binding|poly(A) RNA binding|chromo shadow domain binding|,9,3.1,14.5,9,3.3,4.14,3.2,18.3,0.00194,1.8,5.6
ENSMUSG00000036835,PSENEN,presenilin enhancer gamma secretase subunit,endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|Golgi cisterna membrane|,membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|protein processing|membrane protein intracellular domain proteolysis|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|neurotrophin TRK receptor signaling pathway|apoptotic signaling pathway|,protein binding|,9,-5.3,2.95,10,-4.2,15.8,-4.2,18.3,0.00194,-8.1,-1.4
ENSMUSG00000003271,SULT2B1,"sulfotransferase family, cytosolic, 2B, member 1",nucleus|cytoplasm|endoplasmic reticulum|cytosol|intracellular membrane-bounded organelle|,sulfate assimilation|xenobiotic metabolic process|steroid metabolic process|small molecule metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|,alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity|,10,-4.6,6.81,10,-5.2,11.8,-4.6,18.1,0.00206,-7.2,-2.6
ENSMUSG00000027401,TGM3,transglutaminase 3,cytoplasm|extrinsic component of cytoplasmic side of plasma membrane|extracellular vesicular exosome|,cellular protein modification process|peptide cross-linking|keratinocyte differentiation|keratinocyte differentiation|hair follicle morphogenesis|keratinization|cell envelope organization|protein tetramerization|,"protein-glutamine gamma-glutamyltransferase activity|catalytic activity|calcium ion binding|transferase activity, transferring acyl groups|",10,8.9,18.4,9,3.3,3.13,8.7,17.8,0.00224,3.2,18.3
ENSMUSG00000026708,CENPL,centromere protein L,"chromosome, centromeric region|nucleus|cytosol|",mitotic cell cycle|,None,6,-4.2,6.81,8,-3.6,11.5,-4,17.8,0.00224,-7.3,-2.2
ENSMUSG00000042474,FAIM3,Fas apoptotic inhibitory molecule 3,extracellular region|integral component of membrane|,immune system process|cellular defense response|negative regulation of apoptotic process|,None,10,-2.5,1.56,10,-6.5,17.4,-2.3,17.5,0.00248,-10.6,-1.1
ENSMUSG00000013698,PEA15A,phosphoprotein enriched in astrocytes 15A,intracellular|cytoplasm|microtubule associated complex|,transport|apoptotic process|carbohydrate transport|intracellular signal transduction|regulation of apoptotic process|negative regulation of glucose import|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|,protein kinase C binding|,9,-5,4.68,9,-4.9,12.9,-4.9,17.2,0.00286,-8.4,-2.4
ENSMUSG00000026162,NHEJ1,nonhomologous end-joining factor 1,nucleus|nonhomologous end joining complex|,double-strand break repair via nonhomologous end joining|DNA recombination|central nervous system development|response to ionizing radiation|B cell differentiation|T cell differentiation|positive regulation of ligase activity|,DNA binding|protein binding|,9,-4.7,5.9,9,-6.2,11.5,-4.9,16.8,0.00344,-9,-1.6
ENSMUSG00000041710,TRPC5,"transient receptor potential cation channel, subfamily C, member 5",plasma membrane|integral component of plasma membrane|calcium channel complex|,calcium ion transport|nervous system development|axon guidance|ion transmembrane transport|transmembrane transport|calcium ion transmembrane transport|,"calcium channel activity|protein binding|store-operated calcium channel activity|inositol 1,4,5 trisphosphate binding|",10,-1.5,0.367,10,-4.3,17,-2,16.8,0.00344,-8.7,-0.9
ENSMUSG00000031453,RASA3,RAS p21 protein activator 3,cytoplasm|intrinsic component of the cytoplasmic side of the plasma membrane|,signal transduction|positive regulation of Ras GTPase activity|intracellular signal transduction|negative regulation of Ras protein signal transduction|calcium ion transmembrane transport|,GTPase activator activity|Ras GTPase activator activity|calcium-release channel activity|metal ion binding|,8,-0.9,1.11,8,-6.5,16.4,-6.3,16.3,0.00406,-11.6,-1.1
ENSMUSG00000061808,TTR,transthyretin,extracellular region|extracellular region|extracellular space|cytoplasm|protein complex|extracellular vesicular exosome|,"retinoid metabolic process|transport|phototransduction, visible light|extracellular matrix organization|retinol metabolic process|",hormone activity|protein binding|hormone binding|identical protein binding|protein heterodimerization activity|,10,0.2,0.0989,10,8.1,19.5,8.1,16.1,0.00426,4.8,16
ENSMUSG00000045591,OLIG3,oligodendrocyte transcription factor 3,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|spinal cord motor neuron cell fate specification|spinal cord motor neuron migration|",RNA polymerase II transcription corepressor activity|DNA binding|protein dimerization activity|,0,0,0,1,-6.5,16.3,-6.5,16.1,0.00426,-12,-4
ENSMUSG00000002728,NAA20,"N(alpha)-acetyltransferase 20, NatB catalytic subunit",intracellular|nucleus|cytoplasm|,metabolic process|,peptide alpha-N-acetyltransferase activity|,10,-5.9,5.77,10,-3.8,11.2,-3.9,15.9,0.00456,-7.6,-1.8
ENSMUSG00000024238,ZEB1,zinc finger E-box binding homeobox 1,nucleus|transcription factor complex|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|pattern specification process|cell proliferation|negative regulation of cell proliferation|regulation of mesenchymal cell proliferation|response to activity|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of epithelial cell differentiation|forebrain development|response to nutrient levels|regulation of T cell differentiation in thymus|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic camera-type eye morphogenesis|embryonic skeletal system morphogenesis|semicircular canal morphogenesis|regulation of smooth muscle cell differentiation|cartilage development|cellular response to amino acid stimulus|cellular response to transforming growth factor beta stimulus|cochlea morphogenesis|",chromatin binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein binding|transcription factor binding|zinc ion binding|sequence-specific DNA binding|E-box binding|,9,-3.7,0.919,10,-4.7,15.5,-4.2,15.8,0.0046,-7.7,-2.5
ENSMUSG00000022070,BORA,"bora, aurora kinase A activator",cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|regulation of mitosis|regulation of protein localization|regulation of mitotic spindle organization|,protein binding|protein kinase binding|,5,3.3,6.28,9,4.1,10.1,3.7,15.7,0.00466,2,7.1
ENSMUSG00000032218,CCNB2,cyclin B2,nucleoplasm|centrosome|cytosol|microtubule cytoskeleton|membrane|,regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|mitotic cell cycle|in utero embryonic development|mitotic nuclear division|mitotic nuclear envelope disassembly|growth|T cell homeostasis|thymus development|regulation of cell cycle|,protein binding|protein kinase binding|,10,-3.8,4.24,9,-3.4,12,-3.7,15.7,0.00466,-6.3,-1.8
ENSMUSG00000044641,PARD6B,par-6 family cell polarity regulator beta,nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|tight junction|cell cortex|protein complex|apical part of cell|extracellular vesicular exosome|,protein complex assembly|cell-cell junction assembly|cell cycle|establishment or maintenance of cell polarity|axonogenesis|regulation of cell migration|cell junction assembly|cell-cell junction organization|cell division|tight junction assembly|,protein binding|,10,-5.2,4.82,9,-6.3,11.3,-5.3,15.6,0.00476,-9.5,-1.4
ENSMUSG00000026750,PSMB7,"proteasome (prosome, macropain) subunit, beta type, 7",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome core complex|microtubule cytoskeleton|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",threonine-type endopeptidase activity|protein binding|,4,5.6,16.7,2,-3.3,2.26,5.6,15.4,0.00504,3.3,12
ENSMUSG00000027115,KIF18A,kinesin family member 18A,ruffle|nucleus|cytoplasm|microtubule organizing center|kinetochore microtubule|cytosol|kinesin complex|caveola|microtubule cytoskeleton|,mitotic cell cycle|ATP catabolic process|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|blood coagulation|metabolic process|protein transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|,actin binding|protein binding|ATP binding|microtubule binding|plus-end-directed microtubule motor activity|ubiquitin binding|microtubule plus-end binding|tubulin-dependent ATPase activity|,10,-1.3,0.878,10,-6.5,16.2,-2,15.4,0.00504,-11.3,-0.9
ENSMUSG00000002496,TSC2,tuberous sclerosis 2,nucleus|cytoplasm|cytoplasm|Golgi apparatus|cytosol|cytosol|caveola|membrane|dendrite|growth cone|TSC1-TSC2 complex|neuronal cell body|perinuclear region of cytoplasm|,response to hypoxia|neural tube closure|negative regulation of protein kinase activity|protein import into nucleus|endocytosis|acute-phase response|cell cycle arrest|epidermal growth factor receptor signaling pathway|heart development|protein localization|negative regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|phosphatidylinositol 3-kinase signaling|negative regulation of phosphatidylinositol 3-kinase signaling|vesicle-mediated transport|cell projection organization|regulation of endocytosis|negative regulation of Wnt signaling pathway|negative regulation of TOR signaling|positive regulation of Ras GTPase activity|Fc-epsilon receptor signaling pathway|negative regulation of MAP kinase activity|protein kinase B signaling|innate immune response|negative regulation of cell size|regulation of insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|negative regulation of epithelial cell proliferation|positive chemotaxis|protein homooligomerization|protein heterooligomerization|regulation of cell cycle|negative regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|,GTPase activator activity|protein binding|phosphatase binding|protein homodimerization activity|protein heterodimerization activity|14-3-3 protein binding|,10,-5.7,14.8,9,-2.2,5.68,-5.3,15.2,0.00528,-8.7,-1.5
ENSMUSG00000074928,KRTAP14,keratin associated protein 14,intermediate filament|,None,None,10,-4.6,2.84,10,-5.8,13.2,-5,15.1,0.00536,-9.6,-3.1
ENSMUSG00000025466,FUOM,fucose mutarotase,None,fucose metabolic process|,"racemase and epimerase activity, acting on carbohydrates and derivatives|fucose binding|",3,4,15.1,0,0,0,4,14.9,0.00556,2.9,8.8
ENSMUSG00000041459,TARDBP,TAR DNA binding protein,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|mRNA processing|cell death|RNA splicing|negative regulation by host of viral transcription|3'-UTR-mediated mRNA stabilization|",nucleotide binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|RNA binding|mRNA 3'-UTR binding|protein binding|identical protein binding|poly(A) RNA binding|,5,-5.6,3.16,9,-2.9,12.7,-3.4,14.9,0.00556,-6.7,-1.5
ENSMUSG00000025220,MGEA5,meningioma expressed antigen 5 (hyaluronidase),nucleus|cytoplasm|membrane|,N-acetylglucosamine metabolic process|glycoprotein catabolic process|protein targeting to membrane|aging|positive regulation of calcium ion transport into cytosol|negative regulation of cardiac muscle adaptation|histone acetylation|positive regulation of cell killing|positive regulation of insulin secretion|positive regulation of protein complex disassembly|positive regulation of proteolysis|dATP metabolic process|positive regulation of glucose import|response to steroid hormone|positive regulation of DNA metabolic process|positive regulation of mitochondrial depolarization|negative regulation of protein glycosylation|positive regulation of growth hormone secretion|necrotic cell death|,histone acetyltransferase activity|hyalurononglucosaminidase activity|,9,-2.4,3.34,9,-3.6,12.6,-3.4,14.8,0.0057,-6.3,-1.7
ENSMUSG00000029866,KEL,"Kell blood group, metallo-endopeptidase",plasma membrane|integral component of membrane|,proteolysis|vasoconstriction|,metalloendopeptidase activity|protein binding|metal ion binding|,10,-4.9,1.53,10,-6.5,13.8,-5.2,14.7,0.00586,-11.6,-1.6
ENSMUSG00000029014,DNAJC2,"DnaJ (Hsp40) homolog, subfamily C, member 2",nucleus|cytoplasm|cytosol|nuclear membrane|,"DNA replication|transcription, DNA-templated|chromatin modification|negative regulation of cell growth|positive regulation of transcription, DNA-templated|'de novo' cotranslational protein folding|negative regulation of DNA biosynthetic process|",DNA binding|chromatin binding|Hsp70 protein binding|histone binding|ubiquitin binding|poly(A) RNA binding|,9,-3.7,5.85,9,-4,9.31,-3.8,14.7,0.00586,-6.7,-2
ENSMUSG00000032310,CYP1A2,"cytochrome P450, family 1, subfamily A, polypeptide 2",endoplasmic reticulum membrane|intracellular membrane-bounded organelle|,steroid catabolic process|porphyrin-containing compound metabolic process|xenobiotic metabolic process|toxin biosynthetic process|post-embryonic development|alkaloid metabolic process|regulation of gene expression|monoterpenoid metabolic process|drug metabolic process|dibenzo-p-dioxin metabolic process|arachidonic acid metabolic process|epoxygenase P450 pathway|lung development|methylation|response to estradiol|response to lipopolysaccharide|monocarboxylic acid metabolic process|drug catabolic process|exogenous drug catabolic process|small molecule metabolic process|cellular respiration|heterocycle metabolic process|hydrogen peroxide biosynthetic process|oxidation-reduction process|oxidative demethylation|cellular response to cadmium ion|oxidative deethylation|omega-hydroxylase P450 pathway|,"monooxygenase activity|iron ion binding|electron carrier activity|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|enzyme binding|heme binding|demethylase activity|caffeine oxidase activity|aromatase activity|",10,5.8,9.62,10,3.1,9.17,5.4,14.7,0.00586,2.3,9.2
ENSMUSG00000021287,XRCC3,X-ray repair complementing defective repair in Chinese hamster cells 3,nucleus|replication fork|cytoplasm|mitochondrion|Rad51C-XRCC3 complex|perinuclear region of cytoplasm|,"double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|ATP catabolic process|DNA repair|DNA recombination|cellular response to DNA damage stimulus|response to organic substance|regulation of centrosome duplication|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint|",four-way junction DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|crossover junction endodeoxyribonuclease activity|,9,-5.9,12.1,10,-2.4,7.47,-5.4,14.5,0.00614,-8.1,-2
ENSMUSG00000031575,ASH2L,"ash2 (absent, small, or homeotic)-like (Drosophila)",nucleus|histone methyltransferase complex|histone methyltransferase complex|Set1C/COMPASS complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cellular response to DNA damage stimulus|positive regulation of cell proliferation|hemopoiesis|response to estrogen|positive regulation of transcription from RNA polymerase II promoter|histone H3-K4 methylation|",DNA binding|protein binding|histone methyltransferase activity (H3-K4 specific)|transcription regulatory region DNA binding|metal ion binding|,10,-4.1,7.58,10,-2.5,8.31,-3.2,14.5,0.00614,-5.4,-1.4
ENSMUSG00000052144,PPP4R2,"protein phosphatase 4, regulatory subunit 2",nucleus|cytoplasm|centrosome|protein phosphatase 4 complex|,mRNA processing|cellular protein modification process|RNA splicing|regulation of double-strand break repair via homologous recombination|regulation of catalytic activity|,"protein binding|protein phosphatase type 4 regulator activity|protein binding, bridging|",9,-6.2,9.12,10,-4.5,6.03,-5.1,14.4,0.00628,-9.4,-2.9
ENSMUSG00000091896,UBE2D2A,ubiquitin-conjugating enzyme E2D 2A,ubiquitin ligase complex|protein complex|,protein polyubiquitination|protein ubiquitination|protein K48-linked ubiquitination|,nucleotide binding|ubiquitin-protein transferase activity|protein binding|ATP binding|ligase activity|acid-amino acid ligase activity|,9,-5.2,2.5,9,-4.9,12.2,-5.1,14.3,0.00636,-9.9,-2
ENSMUSG00000028896,RCC1,regulator of chromosome condensation 1,nuclear chromatin|condensed nuclear chromosome|nucleus|nucleoplasm|cytoplasm|nuclear membrane|,G1/S transition of mitotic cell cycle|mitotic spindle organization|chromosome segregation|mitotic nuclear division|regulation of mitosis|viral process|positive regulation of Ran GTPase activity|positive regulation of Ran GTPase activity|spindle assembly|,chromatin binding|Ran guanyl-nucleotide exchange factor activity|protein binding|nucleosomal DNA binding|histone binding|,10,-4.7,10.8,8,-4.3,3.86,-4.5,14.1,0.00662,-7.3,-2.4
ENSMUSG00000042590,IPO11,importin 11,nucleus|cytoplasm|,ribosomal protein import into nucleus|,Ran GTPase binding|protein transporter activity|,10,-1.3,1.42,10,-4.5,13.7,-3.8,14.1,0.00662,-7.7,-1.2
ENSMUSG00000048368,OMD,osteomodulin,extracellular region|proteinaceous extracellular matrix|Golgi lumen|lysosomal lumen|,carbohydrate metabolic process|cell adhesion|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate catabolic process|small molecule metabolic process|,None,10,4.2,14.4,10,1.5,1.44,2.7,13.9,0.00684,1.2,7.3
ENSMUSG00000060073,PSMA3,"proteasome (prosome, macropain) subunit, alpha type, 3","proteasome complex|nucleus|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|proteasome core complex, alpha-subunit complex|extracellular vesicular exosome|","G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",threonine-type endopeptidase activity|protein binding|,5,4.5,9.37,6,4.1,4.93,4.4,13.8,0.00694,2.5,8.6
ENSMUSG00000028678,KIF2C,kinesin family member 2C,"chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|nucleus|cytosol|kinesin complex|cytoplasmic microtubule|microtubule cytoskeleton|membrane|microtubule plus-end|",mitotic cell cycle|microtubule-based movement|microtubule depolymerization|microtubule depolymerization|chromosome segregation|mitotic nuclear division|blood coagulation|metabolic process|metabolic process|cell proliferation|antigen processing and presentation of exogenous peptide antigen via MHC class II|establishment or maintenance of microtubule cytoskeleton polarity|regulation of chromosome segregation|,microtubule motor activity|protein binding|ATP binding|centromeric DNA binding|microtubule plus-end binding|,10,-5.4,8.44,10,-3.9,6.39,-5.1,13.7,0.00702,-8.1,-2.7
ENSMUSG00000028367,TXN1,thioredoxin 1,extracellular region|nucleus|nucleus|cytoplasm|cytoplasm|mitochondrion|cytosol|cytosol|axon|dendrite|neuronal cell body|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|glycerol ether metabolic process|transport|response to radiation|regulation of protein import into nucleus, translocation|positive regulation of DNA binding|cell redox homeostasis|negative regulation of protein export from nucleus|oxidation-reduction process|oxidation-reduction process|",protein binding|protein disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|enzyme binding|poly(A) RNA binding|,6,5.2,2.41,8,-3.4,13.4,-3.3,13.7,0.00702,-6.7,-1.5
ENSMUSG00000035783,ACTA2,"actin, alpha 2, smooth muscle, aorta",extracellular space|cytoplasm|cytosol|actin cytoskeleton|smooth muscle contractile fiber|protein complex|,muscle contraction|regulation of blood pressure|response to virus|vascular smooth muscle contraction|glomerular mesangial cell development|,ATP binding|protein kinase binding|,10,-3.1,0.834,10,-6.4,14.4,-4.4,13.7,0.00702,-10.9,-0.9
ENSMUSG00000083012,FAM220A,"family with sequence similarity 220, member A",nucleus|,None,None,8,-5,7.16,9,-3.9,7.04,-5,13.6,0.00712,-8.5,-2.1
ENSMUSG00000011752,PGAM1,phosphoglycerate mutase 1 (brain),cytoplasm|cytosol|cytosol|membrane|extracellular vesicular exosome|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|regulation of glycolytic process|dephosphorylation|regulation of pentose-phosphate shunt|small molecule metabolic process|respiratory burst|,bisphosphoglycerate mutase activity|bisphosphoglycerate 2-phosphatase activity|phosphoglycerate mutase activity|phosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|protein kinase binding|,9,-3.2,5.84,8,-3.8,8.31,-3.5,13.6,0.00712,-6.2,-1.5
ENSMUSG00000074802,GAS2L3,growth arrest-specific 2 like 3,cytoplasm|microtubule|actin cytoskeleton|microtubule cytoskeleton|,microtubule cytoskeleton organization|cell cycle arrest|actin cytoskeleton organization|,actin binding|protein binding|microtubule binding|,10,-3.3,3.66,10,-3.6,10.2,-3.5,13.5,0.0072,-6.9,-1
ENSMUSG00000053289,DDX10,DEAD (Asp-Glu-Ala-Asp) box polypeptide 10,None,ATP catabolic process|metabolic process|,RNA helicase activity|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,4,-5.1,2.47,6,-3.1,11.7,-3.2,13.2,0.00748,-7.9,-1.5
ENSMUSG00000006931,LEPREL4,leprecan-like 4,condensed nuclear chromosome|synaptonemal complex|nucleolus|,synaptonemal complex assembly|,None,1,-0.2,0.0189,3,4.5,13.8,4.5,13.1,0.0076,3,8.9
ENSMUSG00000052833,SAE1,SUMO1 activating enzyme subunit 1,nucleus|nucleus|nucleoplasm|cytosol|intracellular membrane-bounded organelle|,regulation of mitotic cell cycle|protein ubiquitination|protein sumoylation|protein sumoylation|protein sumoylation|SMT3-dependent protein catabolic process|positive regulation of catalytic activity|post-translational protein modification|cellular protein metabolic process|,ubiquitin activating enzyme activity|protein binding|protein C-terminus binding|enzyme activator activity|SUMO activating enzyme activity|ATP-dependent protein binding|protein heterodimerization activity|protein heterodimerization activity|,10,-6.2,9.85,10,-2.9,4.61,-3.6,13.1,0.0076,-8.6,-2
ENSMUSG00000028629,EXO5,exonuclease 5,nucleus|cytosol|,"DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|interstrand cross-link repair|","DNA binding|single-stranded DNA 3'-5' exodeoxyribonuclease activity|protein homodimerization activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding|",9,-5,2.48,9,-3.6,11.2,-4.7,13.1,0.0076,-7.6,-2.2
ENSMUSG00000033577,MYO6,myosin VI,"ruffle|nucleus|nucleoplasm|cytoplasm|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|microvillus|coated pit|cell cortex|membrane|cytoplasmic membrane-bounded vesicle|unconventional myosin complex|DNA-directed RNA polymerase II, holoenzyme|endocytic vesicle|axon|clathrin-coated vesicle membrane|filamentous actin|filamentous actin|nuclear membrane|ruffle membrane|neuronal cell body|apical part of cell|clathrin-coated endocytic vesicle|perinuclear region of cytoplasm|perinuclear region of cytoplasm|extracellular vesicular exosome|","protein targeting|intracellular protein transport|endocytosis|endocytosis|synaptic transmission|synapse assembly|sensory perception of sound|locomotory behavior|metabolic process|metabolic process|metabolic process|glutamate secretion|dendrite development|actin filament-based movement|actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|inner ear morphogenesis|auditory receptor cell differentiation|response to drug|positive regulation of transcription from RNA polymerase II promoter|regulation of synaptic plasticity|regulation of secretion|membrane organization|cellular response to electrical stimulus|",motor activity|actin binding|protein binding|calmodulin binding|calmodulin binding|ATP binding|ADP binding|actin filament binding|actin filament binding|minus-end directed microfilament motor activity|,10,-6.6,4.14,10,-1.7,9.77,-4.8,13.1,0.0076,-9.3,-0.9
ENSMUSG00000024913,LRP5,low density lipoprotein receptor-related protein 5,mitochondrion|endoplasmic reticulum|plasma membrane|integral component of membrane|receptor complex|,"gastrulation with mouth forming second|positive regulation of mesenchymal cell proliferation|osteoblast development|glucose catabolic process|endocytosis|cholesterol metabolic process|regulation of blood pressure|positive regulation of cell proliferation|anterior/posterior pattern specification|Wnt signaling pathway|embryonic limb morphogenesis|positive regulation of osteoblast proliferation|somatic stem cell maintenance|extracellular matrix-cell signaling|cell migration involved in gastrulation|cholesterol homeostasis|embryonic digit morphogenesis|regulation of apoptotic process|response to peptide hormone|Wnt signaling pathway involved in dorsal/ventral axis specification|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of mitosis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|bone remodeling|regulation of bone remodeling|bone marrow development|embryonic camera-type eye morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|anatomical structure regression|retina morphogenesis in camera-type eye|embryonic retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|canonical Wnt signaling pathway|bone morphogenesis|branching involved in mammary gland duct morphogenesis|adipose tissue development|cell-cell signaling involved in mammary gland development|regulation of canonical Wnt signaling pathway|regulation of insulin secretion involved in cellular response to glucose stimulus|retinal blood vessel morphogenesis|negative regulation of protein serine/threonine kinase activity|apoptotic process involved in patterning of blood vessels|",protein binding|coreceptor activity|Wnt-protein binding|Wnt-activated receptor activity|,10,-1.5,2.13,10,-3.9,12.3,-1.8,13,0.00774,-7.4,-0.8
ENSMUSG00000039994,TIMELESS,timeless circadian clock,nuclear chromatin|nucleus|nucleus|,"negative regulation of transcription from RNA polymerase II promoter|morphogenesis of an epithelium|transcription, DNA-templated|cellular response to DNA damage stimulus|mitotic nuclear division|circadian rhythm|detection of abiotic stimulus|response to abiotic stimulus|embryo development|lung development|regulation of circadian rhythm|cell cycle phase transition|negative regulation of transcription, DNA-templated|branching morphogenesis of an epithelial tube|",protein binding|protein homodimerization activity|protein heterodimerization activity|,10,2.6,12.5,9,1.6,1.24,2.4,13,0.00774,1,4.5
ENSMUSG00000060679,MRPS9,mitochondrial ribosomal protein S9,nucleolus|mitochondrion|mitochondrial small ribosomal subunit|,"translation|DNA damage response, detection of DNA damage|peptide biosynthetic process|",structural constituent of ribosome|protein binding|poly(A) RNA binding|,10,-4.2,1.1,10,-3.7,12.2,-3.8,13,0.00774,-7.1,-1.1
ENSMUSG00000079445,B3GNT7,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",Golgi membrane|integral component of membrane|,carbohydrate metabolic process|O-glycan processing|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|,galactosyltransferase activity|,10,-3.6,5.38,10,-3.1,8.06,-3.4,12.9,0.00794,-5.6,-1.3
ENSMUSG00000037159,WEE2,WEE1 homolog 2 (S. pombe),nucleus|cytoplasm|,mitotic nuclear division|female meiotic division|peptidyl-tyrosine phosphorylation|female pronucleus assembly|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of meiosis I|negative regulation of oocyte maturation|,magnesium ion binding|protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|,10,0,0,10,-4.6,13.6,-4.4,12.7,0.00818,-9.5,-1.2
ENSMUSG00000055884,FANCM,"Fanconi anemia, complementation group M",nucleus|nucleoplasm|Fanconi anaemia nuclear complex|FANCM-MHF complex|,resolution of meiotic recombination intermediates|DNA repair|replication fork processing|nucleic acid phosphodiester bond hydrolysis|,DNA binding|chromatin binding|helicase activity|nuclease activity|protein binding|ATP binding|,10,0.3,0.0119,10,-4.3,15.5,-3.9,12.7,0.00818,-8.2,-1.5
ENSMUSG00000029414,KNTC1,kinetochore associated 1,condensed chromosome kinetochore|spindle pole|nucleus|cytoplasm|kinetochore microtubule|cytosol|plasma membrane|actin cytoskeleton|,mitotic cell cycle|protein complex assembly|mitotic nuclear division|mitotic cell cycle checkpoint|regulation of exit from mitosis|,protein binding|,10,-4,5.96,9,-3.6,7.21,-4,12.7,0.00818,-6.4,-2
ENSMUSG00000031821,GINS2,GINS complex subunit 2 (Psf2 homolog),nucleoplasm|,mitotic cell cycle|DNA strand elongation involved in DNA replication|,protein binding|,10,-3,4.69,10,-4.4,9.05,-3.4,12.6,0.00832,-6.5,-2.1
ENSMUSG00000055041,COMMD5,COMM domain containing 5,nucleus|,None,protein binding|,9,-0.4,0.299,10,-6.6,15.6,-6.5,12.6,0.00832,-12.1,-1
ENSMUSG00000034462,PKD2,polycystic kidney disease 2 (autosomal dominant),polycystin complex|cytoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|cilium|basal plasma membrane|lamellipodium|motile primary cilium|nonmotile primary cilium|filamentous actin|ciliary basal body|basal cortex|ciliary membrane|extracellular vesicular exosome|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane|mitotic spindle|,"branching involved in ureteric bud morphogenesis|liver development|embryonic placenta development|heart looping|detection of nodal flow|calcium ion transport|calcium ion transport|cell cycle arrest|JAK-STAT cascade|determination of left/right symmetry|heart development|negative regulation of cell proliferation|spinal cord development|neural tube development|regulation of cAMP metabolic process|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|cellular response to reactive oxygen species|metanephric part of ureteric bud development|sodium ion transmembrane transport|aorta development|regulation of cell proliferation|cytoplasmic sequestering of transcription factor|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|detection of mechanical stimulus|detection of mechanical stimulus|release of sequestered calcium ion into cytosol|release of sequestered calcium ion into cytosol|centrosome duplication|negative regulation of ryanodine-sensitive calcium-release channel activity|placenta blood vessel development|renal tubule morphogenesis|renal artery morphogenesis|calcium ion transmembrane transport|positive regulation of cell cycle arrest|cellular response to hydrostatic pressure|cellular response to osmotic stress|cellular response to fluid shear stress|potassium ion transmembrane transport|determination of liver left/right asymmetry|metanephric mesenchyme development|mesonephric tubule development|mesonephric duct development|metanephric smooth muscle tissue development|metanephric cortex development|metanephric ascending thin limb development|metanephric cortical collecting duct development|metanephric distal tubule development|metanephric S-shaped body morphogenesis|regulation of calcium ion import|negative regulation of G1/S transition of mitotic cell cycle|",receptor binding|voltage-gated ion channel activity|voltage-gated calcium channel activity|voltage-gated sodium channel activity|potassium channel activity|calcium ion binding|protein binding|cytoskeletal protein binding|voltage-gated cation channel activity|identical protein binding|identical protein binding|protein homodimerization activity|actinin binding|HLH domain binding|ion channel binding|calcium-induced calcium release activity|ATPase binding|phosphoprotein binding|muscle alpha-actinin binding|,10,-3.6,4.37,10,-3.3,8.67,-3.5,12.6,0.00832,-6.3,-1.6
ENSMUSG00000039105,ATP6V1G1,"ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1",lysosomal membrane|cytosol|cytosol|plasma membrane|plasma membrane|vacuolar proton-transporting V-type ATPase complex|extracellular vesicular exosome|,cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|,"hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|ATPase binding|",10,-4.1,14.3,8,-0.1,0.00055,-3.9,12.3,0.00864,-6.7,-1.9
ENSMUSG00000026662,SEPHS1,selenophosphate synthetase 1,cytoplasm|cytoplasm|plasma membrane|plasma membrane|nuclear membrane|nuclear membrane|,cellular protein modification process|phosphorylation|,"selenide, water dikinase activity|protein binding|ATP binding|GTP binding|protein homodimerization activity|protein heterodimerization activity|",10,-4.4,13.1,10,-1.2,2.13,-4.2,12.3,0.00864,-8.1,-1.7
ENSMUSG00000006678,POLA1,"polymerase (DNA directed), alpha 1, catalytic subunit",chromatin|nucleus|nuclear envelope|nucleoplasm|nucleoplasm|alpha DNA polymerase:primase complex|alpha DNA polymerase:primase complex|nucleolus|cytoplasm|nuclear matrix|,"G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic S phase|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA strand elongation involved in DNA replication|leading strand elongation|lagging strand elongation|double-strand break repair via nonhomologous end joining|cell proliferation|viral process|translesion synthesis|telomere maintenance via semi-conservative replication|nucleic acid phosphodiester bond hydrolysis|","nucleotide binding|nucleoside binding|DNA binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity|DNA primase activity|protein binding|3'-5' exonuclease activity|metal ion binding|protein heterodimerization activity|4 iron, 4 sulfur cluster binding|",7,-4.3,6.37,9,-2.6,7.1,-3.8,12.3,0.00864,-6.3,-1.6
ENSMUSG00000046994,MARS2,"methionyl-tRNA synthetase 2, mitochondrial",mitochondrial matrix|mitochondrial matrix|,tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation|cell death|gene expression|,methionine-tRNA ligase activity|ATP binding|,8,-3.9,2.83,8,-3.5,9.82,-3.7,12.2,0.00876,-7,-1.6
ENSMUSG00000058290,ESPL1,extra spindle pole bodies homolog 1 (S. cerevisiae),nucleus|centrosome|cytosol|,mitotic sister chromatid segregation|meiotic spindle organization|mitotic cell cycle|cytokinesis|proteolysis|apoptotic process|establishment of mitotic spindle localization|homologous chromosome segregation|positive regulation of mitotic metaphase/anaphase transition|negative regulation of sister chromatid cohesion|,catalytic activity|protein binding|cysteine-type peptidase activity|cysteine-type peptidase activity|,6,5.7,5.05,5,-6.1,10.6,-5.9,12.2,0.00876,-12,8.2
ENSMUSG00000036158,PRICKLE1,prickle homolog 1 (Drosophila),nucleus|cytosol|cytosol|nuclear membrane|,"neural tube closure|protein import into nucleus|protein import into nucleus|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|",protein binding|zinc ion binding|,1,6.4,8.81,1,3.9,4.26,6.2,12.2,0.00876,4.3,13
ENSMUSG00000025261,HUWE1,"HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase",nucleus|nucleus|cytoplasm|membrane|extracellular vesicular exosome|,protein polyubiquitination|base-excision repair|protein monoubiquitination|histone ubiquitination|cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|,DNA binding|ubiquitin-protein transferase activity|protein binding|ligase activity|poly(A) RNA binding|,10,-2.8,3.64,10,-2.7,8.82,-2.8,12.1,0.0089,-5.6,-1.4
ENSMUSG00000024231,CUL2,cullin 2,nucleus|nucleoplasm|cytosol|VCB complex|Cul2-RING ubiquitin ligase complex|,G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process|cell cycle arrest|negative regulation of cell proliferation|viral process|protein ubiquitination|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|intrinsic apoptotic signaling pathway|,protein binding|ubiquitin protein ligase binding|protein complex binding|,9,-4,6.2,6,-3.2,6.55,-3.8,12,0.00918,-6.8,-1.4
ENSMUSG00000057130,TXNL4A,thioredoxin-like 4A,nucleoplasm|spliceosomal complex|,"spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mitotic nuclear division|RNA splicing|gene expression|",protein binding|,7,5.6,14.9,7,-3.1,4.54,5.5,12,0.00918,2.8,11.8
ENSMUSG00000024791,CDCA5,cell division cycle associated 5,"chromosome, centromeric region|nuclear chromatin|nucleus|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|plasma membrane|cohesin complex|",G1/S transition of mitotic cell cycle|mitotic cell cycle|double-strand break repair|mitotic sister chromatid cohesion|mitotic nuclear division|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic interphase|regulation of cohesin localization to chromatin|,chromatin binding|protein binding|,8,2.8,6.77,9,6.8,8.09,2.5,12,0.00918,1.4,10.2
ENSMUSG00000025467,PRAP1,proline-rich acidic protein 1,extracellular region|,None,None,9,-3.6,2.22,10,-3.6,10,-3.6,11.9,0.00928,-6.4,-1.6
ENSMUSG00000051316,TAF7,"TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa",nucleus|transcription factor TFIID complex|Golgi apparatus|positive transcription elongation factor complex b|transcription factor TFTC complex|MLL1 complex|,"negative regulation of transcription from RNA polymerase II promoter|spermine transport|DNA-templated transcription, initiation|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|intracellular estrogen receptor signaling pathway|negative regulation of histone acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|histone acetyltransferase binding|vitamin D receptor binding|transcription regulatory region DNA binding|thyroid hormone receptor binding|,10,-1,1.58,10,-4,11.5,-3.4,11.9,0.00928,-7.3,-1.2
ENSMUSG00000022122,EDNRB,endothelin receptor type B,plasma membrane|integral component of plasma membrane|nuclear membrane|membrane raft|,negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|positive regulation of protein phosphorylation|regulation of pH|cell surface receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|nervous system development|peripheral nervous system development|posterior midgut development|aging|regulation of blood pressure|positive regulation of cell proliferation|negative regulation of neuron maturation|response to organic cyclic compound|vein smooth muscle contraction|sensory perception of pain|cGMP-mediated signaling|melanocyte differentiation|regulation of fever generation|negative regulation of cellular protein metabolic process|enteric smooth muscle cell differentiation|positive regulation of urine volume|positive regulation of renal sodium excretion|epithelial fluid transport|vasoconstriction|vasodilation|negative regulation of apoptotic process|macrophage chemotaxis|response to pain|enteric nervous system development|regulation of epithelial cell proliferation|regulation of sensory perception of pain|positive regulation of penile erection|cellular response to lipopolysaccharide|endothelin receptor signaling pathway|endothelin receptor signaling pathway|endothelin receptor signaling pathway|,endothelin receptor activity|endothelin receptor activity|protein binding|peptide hormone binding|type 1 angiotensin receptor binding|,10,-5.6,8.02,10,-4.4,4.6,-5.5,11.9,0.00928,-8.8,-2.8
ENSMUSG00000005262,UFD1L,ubiquitin fusion degradation 1 like (yeast),nucleus|cytosol|,skeletal system development|ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|,ubiquitin-specific protease activity|receptor binding|protein binding|protein complex binding|,8,4.3,4.1,9,3.1,8.51,3.3,11.9,0.00928,1.5,7
ENSMUSG00000085793,LIN52,lin-52 DREAM MuvB core complex component,nucleoplasm|DRM complex|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|transcription, DNA-templated|regulation of cell cycle|",None,6,-3.1,3.29,7,-3.4,8.74,-3.2,11.7,0.00964,-6,-1.5
ENSMUSG00000029505,EP400,E1A binding protein p400,Swr1 complex|nucleoplasm|nuclear speck|NuA4 histone acetyltransferase complex|,chromatin organization|histone H4 acetylation|histone H2A acetylation|,DNA binding|chromatin binding|helicase activity|ATP binding|,10,-3.8,7.17,10,-2.4,5.07,-3.6,11.6,0.00982,-6.5,-1.4
ENSMUSG00000036980,TAF6,"TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa",nucleus|nucleoplasm|transcription factor TFIID complex|cytoplasm|transcription factor TFTC complex|MLL1 complex|,"DNA-templated transcription, initiation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|negative regulation of cell proliferation|gene expression|viral process|negative regulation of cell cycle|regulation of sequence-specific DNA binding transcription factor activity|",DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|protein heterodimerization activity|,9,-3.4,2.33,9,-2.7,9.73,-2.8,11.6,0.00982,-5.2,-1.1
ENSMUSG00000026109,TMEFF2,transmembrane protein with EGF-like and two follistatin-like domains 2,extracellular region|integral component of membrane|,None,molecular_function|,10,-2.5,1.78,10,-6.1,11,-4.1,11.6,0.00982,-9.6,-0.8
ENSMUSG00000028851,NUDC,nudC nuclear distribution protein,nucleoplasm|cytoplasm|cytosol|microtubule|,mitotic cell cycle|mitotic nuclear division|multicellular organismal development|cell proliferation|,None,9,-3.9,2.9,9,-3.2,8.89,-3.2,11.4,0.0102,-6.8,-1
ENSMUSG00000071317,BVES,blood vessel epicardial substance,plasma membrane|tight junction|integral component of membrane|integral component of membrane|lateral plasma membrane|,positive regulation of receptor recycling|muscle organ development|regulation of cell shape|vesicle-mediated transport|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|positive regulation of locomotion|regulation of Cdc42 GTPase activity|epithelial cell-cell adhesion|,structural molecule activity|,10,-5.4,5,9,-2.6,8.54,-3.4,11.2,0.0108,-6.7,-1.2
ENSMUSG00000030079,RUVBL1,RuvB-like AAA ATPase 1,Swr1 complex|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|microtubule organizing center|membrane|nuclear matrix|Ino80 complex|NuA4 histone acetyltransferase complex|intracellular membrane-bounded organelle|extracellular vesicular exosome|MLL1 complex|,"DNA repair|DNA recombination|chromatin organization|nucleosome assembly|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mitotic nuclear division|spermatogenesis|DNA duplex unwinding|DNA duplex unwinding|centromere-specific nucleosome assembly|regulation of growth|histone H4 acetylation|histone H2A acetylation|",DNA helicase activity|protein binding|ATP binding|,4,-3.6,7.66,4,-2.5,4.62,-3.3,11.2,0.0108,-6.5,-1.6
ENSMUSG00000027284,CDAN1,codanin 1,nucleus|cytoplasm|plasma membrane|endomembrane system|integral component of membrane|,chromatin organization|protein localization|negative regulation of DNA replication|chromatin assembly|,protein binding|,8,-2.8,1.52,8,-4.9,11.1,-4,11.2,0.0108,-8,-2.2
ENSMUSG00000042606,HIRIP3,HIRA interacting protein 3,nucleus|,chromatin assembly or disassembly|,protein binding|,0,0,0,1,7,11.3,7,11.1,0.011,4.9,14
ENSMUSG00000002949,TIMM44,translocase of inner mitochondrial membrane 44 homolog (yeast),mitochondrion|mitochondrial inner membrane|mitochondrial matrix|,protein targeting to mitochondrion|cellular protein metabolic process|protein transmembrane transport|,protein binding|ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|,6,-4.3,7.17,9,5.7,5.68,-4.3,11.1,0.011,-9,6.5
ENSMUSG00000024286,CCNY,cyclin Y,cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|Wnt signaling pathway|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|regulation of canonical Wnt signaling pathway|,protein binding|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|,8,-2.1,2.27,10,-2.8,9.5,-2.6,11.1,0.011,-5.1,-1
ENSMUSG00000020720,PSMD12,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 12",nucleoplasm|cytosol|proteasome regulatory particle|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",None,6,2.6,6.85,6,-2.9,6.41,3.5,11,0.0112,-3.5,11
ENSMUSG00000024137,E4F1,E4F transcription factor 1,nucleus|nucleoplasm|cytoplasm|spindle|,"negative regulation of transcription from RNA polymerase II promoter|DNA replication|transcription, DNA-templated|mitotic nuclear division|cell proliferation|embryo development|regulation of mitotic cell cycle, embryonic|regulation of cell cycle process|viral process|protein ubiquitination|regulation of growth|mitotic cell cycle arrest|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein binding|ligase activity|cAMP response element binding|metal ion binding|,9,3.1,6.29,9,2.6,5.18,2.9,10.9,0.0115,0.9,7.5
ENSMUSG00000028394,POLE3,"polymerase (DNA directed), epsilon 3, accessory subunit",nucleus|Ada2/Gcn5/Ada3 transcription activator complex|epsilon DNA polymerase complex|,DNA replication|DNA-dependent DNA replication|DNA-dependent DNA replication|histone H3 acetylation|,DNA-directed DNA polymerase activity|protein binding|sequence-specific DNA binding|protein heterodimerization activity|,9,-5.3,11.9,9,-1.7,0.956,-3,10.8,0.0118,-9.9,-1.1
ENSMUSG00000020453,PATZ1,POZ (BTB) and AT hook containing zinc finger 1,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|male gonad development|T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|",DNA binding|chromatin binding|metal ion binding|,10,-3.6,7.65,10,-4.6,3.67,-3.6,10.8,0.0118,-7.5,-2.1
ENSMUSG00000021258,CCNK,cyclin K,cyclin K-CDK12 complex|cyclin K-CDK13 complex|nucleus|,"regulation of cyclin-dependent protein serine/threonine kinase activity|in utero embryonic development|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein phosphorylation|cellular response to DNA damage stimulus|mitotic nuclear division|negative regulation of cell cycle arrest|",cyclin-dependent protein serine/threonine kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity|protein kinase binding|,8,-3.9,5.7,9,-2.5,5.81,-2.9,10.7,0.0119,-5.7,-0.9
ENSMUSG00000009733,TFCP2,transcription factor CP2,cellular_component|nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|,10,0,0,10,-5.2,12.4,-5,10.7,0.0119,-10.9,-1.5
ENSMUSG00000025979,MOB4,"MOB family member 4, phocein",cytoplasm|Golgi apparatus|Golgi cisterna membrane|perinuclear region of cytoplasm|,transport|,protein binding|kinase binding|metal ion binding|,9,-3.1,1.79,9,-4.6,9.7,-3.7,10.7,0.0119,-8.4,-0.7
ENSMUSG00000050552,LAMTOR4,"late endosomal/lysosomal adaptor, MAPK and MTOR activator 4",lysosome|intracellular membrane-bounded organelle|Ragulator complex|,regulation of cell size|positive regulation of TOR signaling|positive regulation of GTPase activity|protein localization to lysosome|cellular response to amino acid stimulus|,guanyl-nucleotide exchange factor activity|protein complex scaffold|,7,-3.9,4.38,8,-2.4,7.13,-2.6,10.7,0.0119,-5.6,-0.9
ENSMUSG00000038252,NCAPD2,"non-SMC condensin I complex, subunit D2",nuclear chromosome|condensed chromosome|condensin complex|condensin core heterodimer|nucleus|nucleus|cytoplasm|cytoplasm|cytoplasm|cytosol|membrane|pronucleus|,mitotic cell cycle|mitotic chromosome condensation|mitotic chromosome condensation|,protein binding|histone binding|histone binding|,6,-3.8,7.04,5,-2.9,4.16,-3.7,10.6,0.0122,-7.6,-1.2
ENSMUSG00000030400,ERCC2,excision repair cross-complementation group 2,nucleus|nucleoplasm|holo TFIIH complex|holo TFIIH complex|cytoplasm|spindle|cyclin-dependent protein kinase activating kinase holoenzyme complex|MMXD complex|,"nucleotide-excision repair, DNA damage removal|response to hypoxia|in utero embryonic development|ATP catabolic process|ATP catabolic process|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|apoptotic process|response to oxidative stress|chromosome segregation|aging|cell proliferation|UV protection|post-embryonic development|gene expression|viral process|spinal cord development|extracellular matrix organization|bone mineralization|central nervous system myelin formation|DNA duplex unwinding|DNA duplex unwinding|nucleotide-excision repair, DNA incision|multicellular organism growth|hair cell differentiation|embryonic cleavage|erythrocyte maturation|positive regulation of DNA binding|small molecule metabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|hair follicle maturation|positive regulation of viral transcription|hematopoietic stem cell differentiation|regulation of mitotic cell cycle phase transition|","DNA binding|ATP-dependent DNA helicase activity|protein kinase activity|protein binding|ATP binding|protein C-terminus binding|DNA-dependent ATPase activity|DNA-dependent ATPase activity|RNA polymerase II carboxy-terminal domain kinase activity|5'-3' DNA helicase activity|metal ion binding|protein N-terminus binding|4 iron, 4 sulfur cluster binding|",6,4.3,11.4,7,-3,10.1,-4.5,10.5,0.0124,-10,6.6
ENSMUSG00000029191,RFC1,"replication factor C (activator 1) 1, 145kDa",nucleus|nucleoplasm|DNA replication factor C complex|Golgi apparatus|cell junction|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|ATP catabolic process|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|transcription, DNA-templated|telomere maintenance via telomerase|telomere maintenance via semi-conservative replication|positive regulation of catalytic activity|positive regulation of transcription, DNA-templated|",DNA binding|DNA clamp loader activity|double-stranded DNA binding|protein binding|ATP binding|enzyme activator activity|protein domain specific binding|sequence-specific DNA binding|,9,-3.4,6.74,7,-3,4.15,-3.2,10.5,0.0124,-6.2,-1.3
ENSMUSG00000024981,ACSL5,acyl-CoA synthetase long-chain family member 5,nucleus|nucleolus|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|,long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|triglyceride biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|regulation of extrinsic apoptotic signaling pathway|,long-chain fatty acid-CoA ligase activity|long-chain fatty acid-CoA ligase activity|ATP binding|,10,-5.2,6.05,10,-2.9,6.26,-3.3,10.4,0.0127,-7.1,-1.1
ENSMUSG00000022521,CREBBP,CREB binding protein,histone acetyltransferase complex|nuclear chromatin|condensed chromosome outer kinetochore|nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|nuclear body|,"negative regulation of transcription from RNA polymerase II promoter|response to hypoxia|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|protein complex assembly|signal transduction|Notch signaling pathway|regulation of smoothened signaling pathway|gene expression|viral process|histone acetylation|N-terminal peptidyl-lysine acetylation|germ-line stem cell maintenance|positive regulation of type I interferon production|homeostatic process|embryonic digit morphogenesis|cellular lipid metabolic process|small molecule metabolic process|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|",core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|p53 binding|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|signal transducer activity|protein binding|transcription factor binding|zinc ion binding|acetyltransferase activity|MRF binding|,10,-5.8,5.55,10,-3.7,7.24,-5.3,10.4,0.0127,-8.3,-1.8
ENSMUSG00000001847,RAC1,"ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)",Golgi membrane|phagocytic cup|trans-Golgi network|cytosol|cytosol|plasma membrane|membrane|extrinsic component of plasma membrane|lamellipodium|ruffle membrane|cytoplasmic ribonucleoprotein granule|melanosome|extracellular vesicular exosome|,"positive regulation of protein phosphorylation|auditory receptor cell morphogenesis|mast cell chemotaxis|epithelial cell morphogenesis|GTP catabolic process|cellular component movement|inflammatory response|hyperosmotic response|cell adhesion|cell-matrix adhesion|small GTPase mediated signal transduction|axon guidance|blood coagulation|cell proliferation|response to wounding|anatomical structure morphogenesis|regulation of hydrogen peroxide metabolic process|positive regulation of lamellipodium assembly|viral process|cerebral cortex radially oriented cell migration|embryonic olfactory bulb interneuron precursor migration|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|platelet activation|regulation of cell migration|positive regulation of actin filament polymerization|T cell costimulation|ruffle organization|ruffle organization|negative regulation of interleukin-23 production|substrate adhesion-dependent cell spreading|positive regulation of Rho protein signal transduction|intracellular signal transduction|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|engulfment of apoptotic cell|innate immune response|cell-cell junction organization|bone resorption|positive regulation of DNA replication|neurotrophin TRK receptor signaling pathway|negative regulation of receptor-mediated endocytosis|anatomical structure arrangement|dendrite morphogenesis|cell motility|regulation of defense response to virus by virus|localization within membrane|Wnt signaling pathway, planar cell polarity pathway|regulation of respiratory burst|semaphorin-plexin signaling pathway|dopaminergic neuron differentiation|cochlea morphogenesis|ruffle assembly|apoptotic signaling pathway|",GTPase activity|protein binding|GTP binding|Rab GTPase binding|enzyme binding|protein kinase binding|GTP-dependent protein binding|thioesterase binding|Rho GDP-dissociation inhibitor binding|,8,-5.5,3.26,10,-3,8.41,-3.1,10.4,0.0127,-7.1,-1.2
ENSMUSG00000072082,CCNF,cyclin F,nucleus|centriole|SCF ubiquitin ligase complex|,re-entry into mitotic cell cycle|placenta development|mitotic nuclear division|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|,protein binding|,10,-1.6,2.3,10,-5.9,8.6,-1.7,10.3,0.0131,-9.1,-0.5
ENSMUSG00000029394,CDK2AP1,cyclin-dependent kinase 2 associated protein 1,nucleus|cytoplasm|,mitotic S phase|DNA-dependent DNA replication|protein phosphorylation|,DNA binding|,10,-3.6,8.05,10,-3.3,2.66,-3.5,10.3,0.0131,-6.5,-1.3
ENSMUSG00000001924,UBA1,ubiquitin-like modifier activating enzyme 1,heterochromatin|nucleus|cytoplasm|mitochondrion|lysosomal membrane|cytosol|endosome membrane|desmosome|rough endoplasmic reticulum membrane|extracellular vesicular exosome|,cellular response to DNA damage stimulus|cell death|protein ubiquitination|protein ubiquitination|modification-dependent protein catabolic process|,ubiquitin activating enzyme activity|ubiquitin-protein transferase activity|protein binding|ATP binding|poly(A) RNA binding|,6,-3.2,4.69,5,-3.3,5.97,-3.3,10.3,0.0131,-7,-1.6
ENSMUSG00000026021,SUMO1,small ubiquitin-like modifier 1,nucleus|nuclear pore|nucleoplasm|nucleolus|cytoplasm|PML body|PML body|nuclear speck|dendrite|nuclear membrane|synapse|,"DNA repair|protein sumoylation|protein sumoylation|cytokine-mediated signaling pathway|PML body organization|positive regulation of protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|post-translational protein modification|cellular protein metabolic process|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|palate development|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|protein localization to nuclear pore|",protein binding|transcription factor binding|SUMO ligase activity|ubiquitin protein ligase binding|poly(A) RNA binding|,10,-3.8,5.93,9,-2.1,5.58,-2.3,10.3,0.0131,-5.4,-1
ENSMUSG00000023064,SNCG,"synuclein, gamma (breast cancer-specific protein 1)",microtubule organizing center|spindle|plasma membrane|neuronal cell body|axon terminus|perinuclear region of cytoplasm|extracellular vesicular exosome|,aggressive behavior|synaptic transmission|adult locomotory behavior|regulation of dopamine secretion|response to cocaine|response to drug|regulation of neurotransmitter secretion|synapse organization|cellular response to hydrostatic pressure|,alpha-tubulin binding|beta-tubulin binding|,0,0,0,1,6.9,10.4,6.9,10.2,0.0134,4.8,14
ENSMUSG00000020156,MUM1,melanoma associated antigen (mutated) 1,nucleus|,DNA repair|chromatin organization|,protein binding|nucleosome binding|,10,-3.2,2.28,10,-6.3,9.92,-4.1,10.2,0.0134,-12,6.6
ENSMUSG00000095642,IGHV14-3,immunoglobulin heavy variable V14-3,None,None,None,2,-5.7,5.42,2,-3.3,6.17,-5.4,10.2,0.0134,-10.8,-2.8
ENSMUSG00000094509,IGHV14-1,immunoglobulin heavy variable 14-1,None,None,None,2,-5.7,5.42,2,-3.3,6.17,-5.4,10.2,0.0134,-10.8,-2.8
ENSMUSG00000030695,ALDOA,"aldolase A, fructose-bisphosphate",extracellular region|extracellular space|nucleus|cytosol|actin cytoskeleton|membrane|platelet alpha granule lumen|M band|I band|extracellular vesicular exosome|,"platelet degranulation|carbohydrate metabolic process|fructose metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|glycolytic process|ATP biosynthetic process|striated muscle contraction|actin filament organization|blood coagulation|regulation of cell shape|platelet activation|fructose 1,6-bisphosphate metabolic process|small molecule metabolic process|muscle cell cellular homeostasis|protein homotetramerization|",actin binding|fructose-bisphosphate aldolase activity|protein binding|cytoskeletal protein binding|tubulin binding|identical protein binding|poly(A) RNA binding|fructose binding|,7,-3.5,8.06,7,-2.9,2.69,-3.4,10.2,0.0134,-6.7,-1.7
ENSMUSG00000033790,TUBGCP5,"tubulin, gamma complex associated protein 5",spindle pole|nucleus|cytoplasm|centrosome|cytosol|microtubule|gamma-tubulin ring complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|microtubule nucleation|,microtubule binding|,10,5.7,8.94,9,5.7,1.54,5.7,10.2,0.0134,2.6,11.9
ENSMUSG00000030287,ITPR2,"inositol 1,4,5-trisphosphate receptor, type 2",endoplasmic reticulum membrane|plasma membrane|cell cortex|membrane|integral component of membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane|receptor complex|,response to hypoxia|energy reserve metabolic process|transport|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|blood coagulation|fibroblast growth factor receptor signaling pathway|platelet activation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|inositol phosphate-mediated signaling|regulation of insulin secretion|calcium ion transmembrane transport|cellular response to cAMP|cellular response to ethanol|,"inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion transmembrane transporter activity|phosphatidylinositol binding|",10,-7.7,4.2,10,-3.3,8.03,-3.2,10.2,0.0134,-10.7,-0.8
ENSMUSG00000027394,TTL,tubulin tyrosine ligase,None,microtubule cytoskeleton organization|cellular protein modification process|regulation of axon extension|,tubulin-tyrosine ligase activity|ATP binding|,10,-6.3,5.58,10,-5.2,5.64,-5.9,10.1,0.0139,-10.5,-2.7
ENSMUSG00000025747,TYMS,thymidylate synthetase,nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|,G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|polysaccharide metabolic process|nucleobase-containing compound metabolic process|pyrimidine nucleobase metabolic process|dTMP biosynthetic process|dTTP biosynthetic process|DNA replication|DNA repair|aging|circadian rhythm|deoxyribonucleoside monophosphate biosynthetic process|response to toxic substance|immortalization of host cell by virus|uracil metabolic process|organ regeneration|methylation|response to progesterone|response to vitamin A|response to cytokine|response to drug|small molecule metabolic process|response to ethanol|dUMP metabolic process|pyrimidine nucleoside biosynthetic process|tetrahydrofolate metabolic process|response to organophosphorus|phosphatidylinositol-mediated signaling|developmental growth|cartilage development|response to glucocorticoid|response to folic acid|nucleobase-containing small molecule metabolic process|intestinal epithelial cell maturation|,nucleotide binding|mRNA binding|thymidylate synthase activity|folic acid binding|drug binding|protein homodimerization activity|cofactor binding|,10,-1.7,1.96,10,-3.3,8.98,-2.6,10.1,0.0139,-5.3,-1.1
ENSMUSG00000020755,SAP30BP,SAP30 binding protein,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|positive regulation of cell death|",protein binding|,9,-3,4.39,10,-3.5,6.16,-3.1,10.1,0.0139,-6.9,-1
ENSMUSG00000027323,RAD51,RAD51 recombinase,nuclear chromosome|condensed chromosome|condensed nuclear chromosome|lateral element|nucleus|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|microtubule organizing center|PML body|perinuclear region of cytoplasm|,double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|ATP catabolic process|ATP catabolic process|DNA unwinding involved in DNA replication|DNA repair|double-strand break repair|DNA recombination|mitotic recombination|cellular response to DNA damage stimulus|meiotic nuclear division|reciprocal meiotic recombination|regulation of double-strand break repair via homologous recombination|positive regulation of DNA ligation|protein homooligomerization|cellular response to ionizing radiation|cellular response to camptothecin|,damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|protein C-terminus binding|identical protein binding|single-stranded DNA-dependent ATPase activity|DNA polymerase binding|,9,-4.3,2.78,9,-3.4,7.94,-4.1,10.1,0.0139,-6.8,-1.5
ENSMUSG00000028452,VCP,valosin containing protein,proteasome complex|Hrd1p ubiquitin ligase complex|nucleus|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|lipid particle|cytosol|site of double-strand break|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|extracellular vesicular exosome|,"ATP catabolic process|DNA repair|double-strand break repair|ER to Golgi vesicle-mediated transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|protein ubiquitination|protein ubiquitination|protein N-linked glycosylation via asparagine|translesion synthesis|ER-associated ubiquitin-dependent protein catabolic process|ER-associated ubiquitin-dependent protein catabolic process|ER-associated ubiquitin-dependent protein catabolic process|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|establishment of protein localization|positive regulation of protein catabolic process|protein homooligomerization|aggresome assembly|positive regulation of protein K63-linked deubiquitination|positive regulation of Lys63-specific deubiquitinase activity|",receptor binding|protein binding|ATP binding|lipid binding|ATPase activity|protein phosphatase binding|protein domain specific binding|polyubiquitin binding|protein complex binding|deubiquitinase activator activity|identical protein binding|ADP binding|poly(A) RNA binding|ubiquitin-specific protease binding|,4,-5.2,4.03,4,4,7.7,4.1,10.1,0.0139,1.7,9
ENSMUSG00000032328,TMEM30A,transmembrane protein 30A,endoplasmic reticulum|Golgi apparatus|membrane|integral component of membrane|apical plasma membrane|transport vesicle membrane|,drug transmembrane transport|protein localization to endosome|phospholipid translocation|positive regulation of protein exit from endoplasmic reticulum|,protein binding|,10,2.6,4.32,10,-3.2,8.92,-3.6,10,0.0142,-7.8,-0.9
ENSMUSG00000043962,THRAP3,thyroid hormone receptor associated protein 3,nucleus|mediator complex|exon-exon junction complex|,"regulation of alternative mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|transcription initiation from RNA polymerase II promoter|mRNA processing|RNA splicing|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of mRNA splicing, via spliceosome|mRNA stabilization|",RNA polymerase II transcription cofactor activity|transcription cofactor activity|transcription coactivator activity|receptor activity|protein binding|ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|vitamin D receptor binding|poly(A) RNA binding|thyroid hormone receptor binding|phosphoprotein binding|,10,-3.3,6.17,10,-2.1,4.57,-3,9.98,0.0142,-6,-0.9
ENSMUSG00000038462,UQCRFS1,"ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1",mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|,response to hormone|respiratory electron transport chain|response to drug|cellular metabolic process|small molecule metabolic process|response to antibiotic|hydrogen ion transmembrane transport|,"ubiquinol-cytochrome-c reductase activity|protein complex binding|metal ion binding|2 iron, 2 sulfur cluster binding|",10,3.7,6.99,10,-3.4,11.8,-3.3,9.96,0.0143,-10,3.2
ENSMUSG00000037343,TAF2,"TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa",transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex|,G2/M transition of mitotic cell cycle|transcription initiation from RNA polymerase II promoter|proteolysis|response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter|,protein binding|metallopeptidase activity|zinc ion binding|transcription regulatory region DNA binding|,10,-3.4,3.96,10,-3.8,6.46,-3.5,9.95,0.0144,-7.3,-0.9
ENSMUSG00000025037,MAOA,monoamine oxidase A,mitochondrion|mitochondrial outer membrane|integral component of membrane|,cellular biogenic amine metabolic process|xenobiotic metabolic process|synaptic transmission|neurotransmitter secretion|neurotransmitter catabolic process|neurotransmitter biosynthetic process|dopamine catabolic process|small molecule metabolic process|oxidation-reduction process|,primary amine oxidase activity|,10,-2,0.136,10,-1.7,10.1,-1.8,9.95,0.0144,-10,-0.6
ENSMUSG00000021178,PSMC1,"proteasome (prosome, macropain) 26S subunit, ATPase, 1",proteasome complex|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|proteasome accessory complex|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|ATP binding|ATPase activity|TBP-class protein binding|poly(A) RNA binding|,8,5.6,3.49,6,3.7,8.13,4.3,9.92,0.0144,1.5,10.3
ENSMUSG00000035834,POLR3G,polymerase (RNA) III (DNA directed) polypeptide G (32kD),nuclear chromatin|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|,regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|cell proliferation|cell proliferation|gene expression|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus|,RNA polymerase III activity|DNA-directed RNA polymerase activity|,10,-2.6,3.05,10,-3.2,7.44,-2.9,9.91,0.0144,-6.5,-0.8
ENSMUSG00000066516,KLK1B21,kallikrein 1-related peptidase b21,extracellular space|nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,9,4.3,1.91,10,2.8,8.82,2.9,9.9,0.0145,0.9,6.1
ENSMUSG00000001525,TUBB5,"tubulin, beta 5 class I",nucleus|nucleus|nuclear envelope lumen|cytoplasm|cytoskeleton|microtubule|microtubule|cytoplasmic ribonucleoprotein granule|protein complex|cell body|tubulin complex|extracellular vesicular exosome|,GTP catabolic process|microtubule-based process|microtubule-based process|cellular process|spindle assembly|protein polymerization|,nucleotide binding|GTPase activity|structural constituent of cytoskeleton|GTP binding|protein domain specific binding|protein complex binding|GTPase activating protein binding|MHC class I protein binding|,10,-3.8,5.92,10,-1.9,5.13,-3.5,9.79,0.0148,-6.1,-0.9
ENSMUSG00000056612,PPP1R14B,"protein phosphatase 1, regulatory (inhibitor) subunit 14B",cytoplasm|,regulation of phosphorylation|negative regulation of catalytic activity|,protein phosphatase inhibitor activity|,9,-3.3,6.5,9,-3.2,3.62,-3.3,9.75,0.015,-7,-1.3
ENSMUSG00000051695,PCBP1,poly(rC) binding protein 1,nucleoplasm|cytoplasm|membrane|ribonucleoprotein complex|extracellular vesicular exosome|,"mRNA splicing, via spliceosome|RNA splicing|gene expression|",single-stranded DNA binding|RNA binding|protein binding|poly(A) RNA binding|,10,-1.4,6.25,10,-1.8,4.06,-1.6,9.75,0.015,-3.8,-0.6
ENSMUSG00000023940,SGOL1,shugoshin-like 1 (S. pombe),"chromosome, centromeric region|kinetochore|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|condensed nuclear chromosome, centromeric region|spindle pole|nucleus|cytoplasm|centrosome|cytosol|mitotic cohesin complex|",mitotic cell cycle|chromosome segregation|mitotic nuclear division|attachment of spindle microtubules to kinetochore|centriole-centriole cohesion|centriole-centriole cohesion|meiotic chromosome segregation|,protein binding|kinase binding|,9,6,5.02,9,5.9,5.09,6,9.74,0.0151,2.8,12.8
ENSMUSG00000030528,BLM,"Bloom syndrome, RecQ helicase-like","nuclear chromosome|chromosome, telomeric region|lateral element|male germ cell nucleus|nucleus|replication fork|nucleolus|cytoplasm|nuclear matrix|PML body|PML body|pronucleus|","regulation of cyclin-dependent protein serine/threonine kinase activity|mitotic G2 phase|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|DNA strand renaturation|ATP catabolic process|ATP catabolic process|DNA repair|DNA recombination|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|response to X-ray|replication fork processing|G2 DNA damage checkpoint|DNA duplex unwinding|DNA duplex unwinding|DNA duplex unwinding|positive regulation of transcription, DNA-templated|negative regulation of DNA recombination|negative regulation of mitotic recombination|alpha-beta T cell differentiation|positive regulation of alpha-beta T cell proliferation|replication fork protection|regulation of binding|protein oligomerization|negative regulation of cell division|negative regulation of thymocyte apoptotic process|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|",bubble DNA binding|p53 binding|single-stranded DNA binding|ATP-dependent DNA helicase activity|ATP-dependent DNA helicase activity|helicase activity|protein binding|ATP binding|ATP-dependent helicase activity|four-way junction helicase activity|ATPase activity|annealing helicase activity|ATP-dependent 3'-5' DNA helicase activity|G-quadruplex DNA binding|,10,-4.1,1.35,10,-4.9,8.7,-4.1,9.71,0.0152,-9,-1.8
ENSMUSG00000056216,CEBPG,"CCAAT/enhancer binding protein (C/EBP), gamma",nucleus|nucleus|,"liver development|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|mRNA metabolic process|B cell differentiation|natural killer cell mediated cytotoxicity|enucleate erythrocyte differentiation|positive regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of interferon-gamma biosynthetic process|positive regulation of DNA repair|positive regulation of sequence-specific DNA binding transcription factor activity|",DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|sequence-specific DNA binding|protein heterodimerization activity|,10,-3.9,2.04,10,-3.5,8.01,-3.7,9.67,0.0154,-7.1,-1.7
ENSMUSG00000025809,ITGB1,"integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)",acrosomal vesicle|ruffle|basement membrane|cytoplasm|plasma membrane|plasma membrane|focal adhesion|focal adhesion|integrin complex|external side of plasma membrane|cell surface|intercalated disc|membrane|lamellipodium|hemidesmosome|filopodium|neuromuscular junction|cleavage furrow|ruffle membrane|integrin alpha3-beta1 complex|integrin alpha7-beta1 complex|integrin alpha8-beta1 complex|integrin alpha9-beta1 complex|myelin sheath abaxonal region|sarcolemma|melanosome|receptor complex|membrane raft|recycling endosome|extracellular vesicular exosome|,G1/S transition of mitotic cell cycle|in utero embryonic development|cell fate specification|tissue homeostasis|cell migration involved in sprouting angiogenesis|cellular calcium ion homeostasis|cellular defense response|homophilic cell adhesion|leukocyte cell-cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|integrin-mediated signaling pathway|axon guidance|blood coagulation|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation|negative regulation of cell proliferation|germ cell migration|response to virus|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|response to activity|viral process|cell migration|formation of radial glial scaffolds|B cell differentiation|extracellular matrix organization|positive regulation of cell migration|negative regulation of cell projection organization|cell-substrate adhesion|protein transport within lipid bilayer|cell-cell adhesion mediated by integrin|cell junction assembly|response to gonadotropin|response to drug|positive regulation of apoptotic process|positive regulation of MAPK cascade|sarcomere organization|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of endocytosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|leukocyte migration|regulation of cell cycle|cardiac muscle cell differentiation|maternal process involved in female pregnancy|tight junction assembly|cellular response to mechanical stimulus|cellular response to vitamin D|cellular response to ionizing radiation|response to transforming growth factor beta|negative regulation of anoikis|,virus receptor activity|glycoprotein binding|fibronectin binding|protease binding|actin binding|integrin binding|protein binding|collagen binding|protein kinase binding|protein domain specific binding|peptide binding|laminin binding|metal ion binding|protein heterodimerization activity|cell adhesion molecule binding|alpha-actinin binding|,10,0.8,0.917,10,-4.7,12.2,-4.6,9.67,0.0154,-8.6,-2.3
ENSMUSG00000026234,NCL,nucleolin,nucleus|nucleoplasm|nucleolus|cell cortex|membrane|ribonucleoprotein complex|cytoplasmic ribonucleoprotein granule|extracellular vesicular exosome|,angiogenesis|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|,nucleotide binding|RNA binding|protein binding|protein C-terminus binding|telomeric DNA binding|identical protein binding|poly(A) RNA binding|,8,-2.3,3.13,8,-2.6,6.88,-2.5,9.59,0.0157,-6.1,-1.1
ENSMUSG00000069922,CES3A,carboxylesterase 3A,endoplasmic reticulum|extracellular vesicular exosome|,biological_process|,hydrolase activity|carboxylic ester hydrolase activity|,10,-3.3,3.08,10,-3.3,6.86,-3.3,9.59,0.0157,-7.2,-1
ENSMUSG00000031386,HCFC1,host cell factor C1,histone acetyltransferase complex|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|mitochondrion|membrane|neuronal cell body|Set1C/COMPASS complex|SAGA-type complex|MLL5-L complex|MLL1 complex|,"negative regulation of transcription from RNA polymerase II promoter|chromatin organization|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cell cycle|positive regulation of gene expression|release from viral latency|regulation of protein complex assembly|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|positive regulation of cell cycle|protein stabilization|",chromatin binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|identical protein binding|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|histone acetyltransferase activity (H4-K16 specific)|,6,-3.4,2.05,8,-2.6,7.93,-2.6,9.52,0.0161,-5.6,-0.7
ENSMUSG00000027715,CCNA2,cyclin A2,female pronucleus|male pronucleus|nucleus|nucleoplasm|cytoplasm|,"regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|mitotic G2 DNA damage checkpoint|Ras protein signal transduction|regulation of G2/M transition of mitotic cell cycle|organ regeneration|response to estradiol|response to glucagon|positive regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|",protein binding|protein kinase binding|,9,-3.6,5.98,6,-2.3,4.58,-3.4,9.51,0.0161,-6.6,-1
ENSMUSG00000027829,CCNL1,cyclin L1,nucleus|nuclear speck|,"regulation of cyclin-dependent protein serine/threonine kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|",protein kinase binding|,10,-3.2,0.736,10,-2.9,9.03,-3.1,9.48,0.0162,-5.8,-1
ENSMUSG00000030342,CD9,CD9 molecule,extracellular space|plasma membrane|integral component of plasma membrane|external side of plasma membrane|apical plasma membrane|platelet alpha granule membrane|extracellular vesicular exosome|,platelet degranulation|cellular component movement|cell adhesion|single fertilization|fusion of sperm to egg plasma membrane|fusion of sperm to egg plasma membrane|brain development|blood coagulation|negative regulation of cell proliferation|response to water deprivation|oligodendrocyte development|platelet activation|platelet activation|paranodal junction assembly|multicellular organism reproduction|,integrin binding|protein binding|,10,-1.8,5.01,9,-2.2,4.96,-2,9.47,0.0163,-7.7,-0.8
ENSMUSG00000038058,NOD1,nucleotide-binding oligomerization domain containing 1,cytoplasm|cytoplasm|cytosol|basolateral plasma membrane|apical plasma membrane|,"activation of MAPK activity|toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|inflammatory response|signal transduction|JNK cascade|detection of biotic stimulus|detection of bacterium|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|intracellular signal transduction|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|interleukin-8 biosynthetic process|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|positive regulation of JNK cascade|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|",protein binding|ATP binding|cysteine-type endopeptidase activator activity involved in apoptotic process|identical protein binding|identical protein binding|protein homodimerization activity|peptidoglycan binding|CARD domain binding|,10,-4.9,6.35,10,-2.6,4.96,-4.7,9.45,0.0163,-7.6,-1.3
ENSMUSG00000055491,PPRC1,"peroxisome proliferator-activated receptor gamma, coactivator-related 1",nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",nucleotide binding|poly(A) RNA binding|,10,-2.7,7.57,10,-1.4,3.04,-2.4,9.33,0.0168,-4.5,-0.8
ENSMUSG00000040761,SPEN,spen family transcriptional repressor,nucleus|transcriptional repressor complex|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|Notch signaling pathway|viral process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of neurogenesis|",nucleotide binding|RNA polymerase II transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|single-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|poly(A) RNA binding|,10,2.7,7.19,10,-3.2,8.38,-3.2,9.32,0.0168,-10,2.8
ENSMUSG00000024622,HMGXB3,HMG box domain containing 3,cellular_component|nucleus|,biological_process|phosphorylation|,DNA binding|kinase activity|,0,0,0,1,6.8,9.51,6.8,9.32,0.0168,4.5,13
ENSMUSG00000053754,CHD8,chromodomain helicase DNA binding protein 8,nucleus|protein complex|MLL1 complex|,"in utero embryonic development|ATP catabolic process|transcription, DNA-templated|negative regulation of Wnt signaling pathway|DNA duplex unwinding|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|canonical Wnt signaling pathway|negative regulation of fibroblast apoptotic process|",p53 binding|DNA binding|DNA helicase activity|protein binding|ATP binding|beta-catenin binding|DNA-dependent ATPase activity|methylated histone binding|histone binding|armadillo repeat domain binding|,9,-5.2,9.1,10,-1.8,3.77,-3,9.3,0.017,-7.8,-1.2
ENSMUSG00000024811,TNKS2,"tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2","Golgi membrane|pericentriolar material|nuclear chromosome, telomeric region|nucleus|nuclear envelope|cytoplasm|perinuclear region of cytoplasm|","protein polyubiquitination|protein ADP-ribosylation|Wnt signaling pathway|positive regulation of telomere maintenance via telomerase|multicellular organism growth|regulation of multicellular organism growth|protein localization to chromosome, telomeric region|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|",NAD+ ADP-ribosyltransferase activity|protein binding|enzyme binding|metal ion binding|,10,-2.5,4.61,10,-2.8,5.07,-2.6,9.27,0.0171,-5,-0.8
ENSMUSG00000097386,9130213A22RIK,RIKEN cDNA 9130213A22 gene,cellular_component|,biological_process|,molecular_function|,2,-3,2.94,2,-3.8,6.91,-3.7,9.26,0.0172,-7,-2.1
ENSMUSG00000053886,SH2D4A,SH2 domain containing 4A,cytoplasm|,negative regulation of phosphatase activity|,protein binding|phosphatase binding|,0,0,0,1,-5.9,9.39,-5.9,9.2,0.0176,-11,-3.3
ENSMUSG00000029687,EZH2,enhancer of zeste 2 polycomb repressive complex 2 subunit,nuclear chromatin|nucleus|nucleoplasm|cytoplasm|ESC/E(Z) complex|pronucleus|,"negative regulation of transcription from RNA polymerase II promoter|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of epithelial to mesenchymal transition|regulation of gliogenesis|cerebellar cortex development|positive regulation of Ras GTPase activity|negative regulation of transcription elongation from RNA polymerase II promoter|regulation of cell proliferation|positive regulation of MAP kinase activity|negative regulation of epidermal cell differentiation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|negative regulation of retinoic acid receptor signaling pathway|negative regulation of striated muscle cell differentiation|G1 to G0 transition|histone H3-K27 methylation|positive regulation of protein serine/threonine kinase activity|negative regulation of G1/S transition of mitotic cell cycle|",core promoter binding|DNA binding|chromatin binding|RNA binding|protein binding|chromatin DNA binding|histone methyltransferase activity|sequence-specific DNA binding|histone methyltransferase activity (H3-K27 specific)|,10,-3.2,5.07,10,-2.2,4.92,-2.9,9.14,0.018,-5.7,-0.7
ENSMUSG00000021639,GTF2H2,"general transcription factor IIH, polypeptide 2, 44kDa",core TFIIH complex|nucleoplasm|holo TFIIH complex|,"nucleotide-excision repair, DNA damage removal|G-protein coupled receptor internalization|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|translation|protein phosphorylation|response to UV|gene expression|viral process|positive regulation of viral transcription|","nucleic acid binding|sequence-specific DNA binding transcription factor activity|protein kinase activity|protein binding|DNA-dependent ATPase activity|translation factor activity, nucleic acid binding|zinc ion binding|RNA polymerase II carboxy-terminal domain kinase activity|protein N-terminus binding|",4,-4.4,3.04,7,-3.7,6.52,-4.2,9.11,0.0181,-9.1,-1
ENSMUSG00000031921,TERF2,telomeric repeat binding factor 2,"chromosome, telomeric region|nuclear telomere cap complex|male germ cell nucleus|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|Mre11 complex|","telomere maintenance|telomere maintenance|age-dependent telomere shortening|in utero embryonic development|telomere maintenance via telomerase|cell cycle|telomere maintenance via telomere shortening|telomere capping|telomeric loop formation|protection from non-homologous end joining at telomere|negative regulation of telomere maintenance|positive regulation of telomere maintenance|negative regulation of telomere maintenance via semi-conservative replication|protein localization to chromosome, telomeric region|cellular senescence|",chromatin binding|double-stranded telomeric DNA binding|protein binding|protein C-terminus binding|telomeric DNA binding|protein homodimerization activity|,8,-3.9,7.39,10,-1.8,3.74,-3.6,9.11,0.0181,-6.8,-0.8
ENSMUSG00000027239,MDK,midkine (neurite growth-promoting factor 2),extracellular region|,"behavioral fear response|signal transduction|Notch signaling pathway|nervous system development|short-term memory|response to wounding|cell migration|dentate gyrus development|cerebellar granular layer development|cerebral cortex development|cell differentiation|adrenal gland development|defecation|response to drug|negative regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|regulation of behavior|response to glucocorticoid|positive regulation of cell division|",growth factor activity|heparin binding|,10,-4.2,4.2,10,-5.9,5.54,-5.6,9.06,0.0183,-11,-0.9
ENSMUSG00000028410,DNAJA1,"DnaJ (Hsp40) homolog, subfamily A, member 1",cytosol|membrane|extracellular vesicular exosome|,protein folding|response to unfolded protein|spermatogenesis|response to heat|sperm motility|androgen receptor signaling pathway|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of JUN kinase activity|regulation of protein transport|protein localization to mitochondrion|,protein binding|ATP binding|Hsp70 protein binding|metal ion binding|low-density lipoprotein particle receptor binding|unfolded protein binding|chaperone binding|chaperone binding|,9,-4.3,9.91,10,4.4,0.837,-4.1,9.03,0.0186,-7.6,-1.4
ENSMUSG00000024603,DCTN4,dynactin 4 (p62),nucleus|cytoplasm|centrosome|cytosol|dynactin complex|,antigen processing and presentation of exogenous peptide antigen via MHC class II|,protein N-terminus binding|,10,3,10.7,10,-1.1,1.06,2.8,9.01,0.0186,0.9,7.1
ENSMUSG00000052593,ADAM17,ADAM metallopeptidase domain 17,cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|cell surface|actin cytoskeleton|membrane|apical plasma membrane|ruffle membrane|membrane raft|,"response to hypoxia|positive regulation of protein phosphorylation|neutrophil mediated immunity|germinal center formation|positive regulation of leukocyte chemotaxis|proteolysis|membrane protein ectodomain proteolysis|membrane protein ectodomain proteolysis|apoptotic process|cell adhesion|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor signaling pathway|Notch signaling pathway|Notch receptor processing|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|extracellular matrix disassembly|B cell differentiation|extracellular matrix organization|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|collagen catabolic process|membrane protein intracellular domain proteolysis|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|response to lipopolysaccharide|negative regulation of interleukin-8 production|positive regulation of chemokine production|regulation of mast cell apoptotic process|T cell differentiation in thymus|cell adhesion mediated by integrin|wound healing, spreading of epidermal cells|epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway|response to drug|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of epidermal growth factor-activated receptor activity|neurotrophin TRK receptor signaling pathway|spleen development|cell motility|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cellular component movement|response to high density lipoprotein particle|JAK-STAT cascade involved in growth hormone signaling pathway|apoptotic signaling pathway|",metalloendopeptidase activity|metalloendopeptidase activity|metalloendopeptidase activity|Notch binding|interleukin-6 receptor binding|integrin binding|protein binding|metallopeptidase activity|metallopeptidase activity|metallopeptidase activity|zinc ion binding|SH3 domain binding|PDZ domain binding|,10,-1.6,3.23,10,-2,6.19,-1.8,8.99,0.0188,-4.6,-0.6
ENSMUSG00000025950,IDH1,"isocitrate dehydrogenase 1 (NADP+), soluble",cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|cytosol|extracellular vesicular exosome|,glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|2-oxoglutarate metabolic process|NADPH regeneration|glutathione metabolic process|response to oxidative stress|female gonad development|cellular lipid metabolic process|small molecule metabolic process|response to steroid hormone|,magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|isocitrate dehydrogenase (NADP+) activity|receptor binding|protein homodimerization activity|NADP binding|NAD binding|,10,-4.4,2.39,10,3.1,11,2.8,8.99,0.0188,0.7,6.5
ENSMUSG00000026229,PSMD1,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 1",proteasome complex|nucleoplasm|cytosol|proteasome regulatory particle|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|regulation of protein catabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",enzyme regulator activity|,6,2.2,5.07,8,2.3,4.27,2.2,8.98,0.0188,-5,7
ENSMUSG00000079184,MPHOSPH8,M-phase phosphoprotein 8,nuclear nucleosome|nucleus|nuclear heterochromatin|nucleolus|cytoplasm|plasma membrane|extracellular vesicular exosome|,"transcription, DNA-templated|cell cycle|regulation of DNA methylation|negative regulation of transcription, DNA-templated|",protein binding|methylated histone binding|,10,-7,11.5,10,-1.5,2.95,-6.9,8.97,0.0188,-11.8,-0.7
ENSMUSG00000017716,BIRC5,baculoviral IAP repeat containing 5,"nuclear chromosome|chromosome, centromeric region|condensed chromosome kinetochore|nucleus|cytoplasm|centriole|spindle|cytosol|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|midbody|interphase microtubule organizing center|chromosome passenger complex|","G2/M transition of mitotic cell cycle|mitotic cell cycle|cytokinesis|transcription, DNA-templated|protein phosphorylation|apoptotic process|chromosome segregation|mitotic nuclear division|mitotic nuclear division|positive regulation of cell proliferation|negative regulation of endopeptidase activity|protein complex localization|positive regulation of exit from mitosis|spindle checkpoint|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|cell division|establishment of chromosome localization|",cysteine-type endopeptidase inhibitor activity|protein binding|microtubule binding|microtubule binding|zinc ion binding|zinc ion binding|Ran GTPase binding|tubulin binding|enzyme binding|identical protein binding|protein homodimerization activity|protein homodimerization activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|metal ion binding|protein heterodimerization activity|cofactor binding|cobalt ion binding|chaperone binding|,5,-5.6,7.81,3,-2.5,3.03,-5.3,8.93,0.0191,-12,7.4
ENSMUSG00000037849,GM4955,predicted gene 4955,None,None,None,10,2.7,6.32,10,2,3.14,2.5,8.91,0.0191,-2.6,8.3
ENSMUSG00000042043,TBCA,tubulin folding cofactor A,nucleolus|cytoplasm|microtubule|microtubule cytoskeleton|extracellular vesicular exosome|,protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|cellular protein metabolic process|'de novo' posttranslational protein folding|,poly(A) RNA binding|unfolded protein binding|chaperone binding|,9,-2.6,3.41,8,-2.8,5.83,-2.7,8.87,0.0193,-5.6,-0.8
ENSMUSG00000022285,YWHAZ,"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta",extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|postsynaptic density|cytoplasmic vesicle membrane|cell leading edge|melanosome|mast cell granule|protein complex|perinuclear region of cytoplasm|extracellular vesicular exosome|blood microparticle|,histamine secretion by mast cell|protein targeting to mitochondrion|apoptotic process|signal transduction|blood coagulation|gene expression|RNA metabolic process|mRNA metabolic process|platelet activation|response to drug|negative regulation of apoptotic process|membrane organization|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|,protein binding|transcription factor binding|protein kinase binding|protein domain specific binding|protein complex binding|identical protein binding|poly(A) RNA binding|,8,-4.5,4.33,10,-3.2,5.09,-4.3,8.83,0.0194,-7.6,-1.4
ENSMUSG00000017724,ETV4,ets variant 4,nucleolus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|motor neuron axon guidance|cell differentiation|negative regulation of mammary gland epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|stem cell differentiation|branching involved in mammary gland duct morphogenesis|regulation of branching involved in mammary gland duct morphogenesis|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|,10,-4.4,2.8,10,-3.7,6.44,-4.4,8.83,0.0194,-7.9,-1.6
ENSMUSG00000033054,NPAT,"nuclear protein, ataxia-telangiectasia locus",nucleus|nucleoplasm|cytoplasm|Cajal body|Gemini of coiled bodies|,"regulation of transcription involved in G1/S transition of mitotic cell cycle|transcription, DNA-templated|regulation of gene expression|positive regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription coactivator activity|transcription corepressor activity|protein binding|protein C-terminus binding|protein N-terminus binding|,10,-3.5,2.19,9,-2.6,7.34,-2.8,8.82,0.0195,-5.5,-0.8
ENSMUSG00000050395,TNFSF15,"tumor necrosis factor (ligand) superfamily, member 15",extracellular space|plasma membrane|integral component of plasma membrane|integral component of membrane|,activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|positive regulation of cytokine secretion|,receptor binding|death receptor binding|cytokine activity|tumor necrosis factor receptor binding|,10,-2.3,1.95,9,-4.6,8.04,-3.9,8.82,0.0195,-9.4,-0.7
ENSMUSG00000026069,IL1RL1,interleukin 1 receptor-like 1,extracellular region|external side of plasma membrane|integral component of membrane|,negative regulation of T-helper 1 type immune response|immune response|signal transduction|negative regulation of interferon-gamma production|positive regulation of interleukin-5 production|intracellular signal transduction|interleukin-33-mediated signaling pathway|positive regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of inflammatory response|positive regulation of chemokine secretion|,interleukin-33 binding|interleukin-33 receptor activity|cytokine receptor activity|interleukin-1 receptor activity|receptor signaling protein activity|protein binding|,1,6.5,8.96,0,0,0,6.5,8.78,0.0197,4.6,14
ENSMUSG00000035198,TUBG1,"tubulin, gamma 1",pericentriolar material|condensed nuclear chromosome|gamma-tubulin complex|cytoplasm|cytoplasm|centrosome|centriole|polar microtubule|cytosol|cytoplasmic microtubule|cell leading edge|nonmotile primary cilium|ciliary basal body|apical part of cell|,G2/M transition of mitotic cell cycle|meiotic spindle organization|microtubule cytoskeleton organization|mitotic cell cycle|GTP catabolic process|microtubule nucleation|cytoplasmic microtubule organization|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|,9,4.6,7.53,8,1.8,1.86,3.6,8.74,0.0199,1.1,9.5
ENSMUSG00000059495,ARHGEF12,Rho guanine nucleotide exchange factor (GEF) 12,cytoplasm|cytosol|membrane|extracellular vesicular exosome|,G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|axon guidance|positive regulation of Rho GTPase activity|termination of G-protein coupled receptor signaling pathway|positive regulation of apoptotic process|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,G-protein coupled receptor binding|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|,9,-4.4,7.41,10,-2.1,2.53,-2.6,8.73,0.02,-6.5,-0.9
ENSMUSG00000037005,XPNPEP2,"X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound",plasma membrane|membrane|anchored component of membrane|extracellular vesicular exosome|,proteolysis|,aminopeptidase activity|metallopeptidase activity|metal ion binding|,1,3.8,4.45,1,4.8,4.83,4.7,8.68,0.0203,2.8,10
ENSMUSG00000041096,TSPYL2,TSPY-like 2,nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|plasma membrane|,"nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|activation of signaling protein activity involved in unfolded protein response|cell cycle|negative regulation of DNA replication|regulation of signal transduction|chromatin modification|negative regulation of cell growth|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|negative regulation of cell cycle|regulation of protein kinase activity|",rDNA binding|,10,0.6,0.275,10,-5,11.7,-4.9,8.62,0.0207,-10.4,-0.7
ENSMUSG00000030956,FAM53B,"family with sequence similarity 53, member B",cellular_component|,biological_process|,molecular_function|,10,-2.9,6.27,10,-1.8,3.15,-2.7,8.61,0.0207,-5.6,-0.6
ENSMUSG00000027447,CST3,cystatin C,extracellular region|extracellular region|extracellular space|extracellular vesicular exosome|,defense response|negative regulation of peptidase activity|negative regulation of collagen catabolic process|negative regulation of extracellular matrix disassembly|negative regulation of extracellular matrix disassembly|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|regulation of tissue remodeling|extracellular fibril organization|negative regulation of proteolysis|negative regulation of elastin catabolic process|negative regulation of blood vessel remodeling|,beta-amyloid binding|protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|,9,-2,0.942,10,7,11.8,7,8.6,0.0209,2.6,14
ENSMUSG00000028907,UTP11L,"UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)",extracellular space|nucleolus|nucleolus|cytoplasm|small-subunit processome|,rRNA processing|nervous system development|ribosomal small subunit biogenesis|positive regulation of apoptotic process|,protein binding|poly(A) RNA binding|,10,-3.6,6.67,8,5,5.03,-3,8.6,0.0209,-10.1,5.5
ENSMUSG00000063550,NUP98,nucleoporin 98kDa,kinetochore|nuclear envelope|nuclear envelope|nuclear pore|nuclear pore|nucleoplasm|cytosol|nuclear pore outer ring|nuclear pore outer ring|nuclear membrane|nuclear periphery|nuclear inclusion body|nuclear pore nuclear basket|,"protein import into nucleus, docking|mitotic cell cycle|carbohydrate metabolic process|DNA replication|nucleocytoplasmic transport|nuclear pore organization|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|mRNA transport|nuclear pore complex assembly|transmembrane transport|",transporter activity|protein binding|structural constituent of nuclear pore|structural constituent of nuclear pore|peptide binding|,10,-4.4,8.17,10,-1.5,2.09,-3.7,8.58,0.0209,-9,-0.6
ENSMUSG00000059891,TSKS,testis-specific serine kinase substrate,centriole|,negative regulation of phosphatase activity|,protein binding|protein kinase binding|,10,-2.3,4.47,10,-2.4,4.43,-2.4,8.54,0.0212,-6.8,1.4
ENSMUSG00000074476,SPC24,"SPC24, NDC80 kinetochore complex component",condensed chromosome kinetochore|nucleus|nucleolus|cytosol|Ndc80 complex|,mitotic cell cycle|mitotic nuclear division|,protein binding|,9,-3.2,2.5,10,4.5,9.05,4.3,8.5,0.0215,1.7,10.1
ENSMUSG00000030042,POLE4,"polymerase (DNA-directed), epsilon 4, accessory subunit",nucleus|Ada2/Gcn5/Ada3 transcription activator complex|epsilon DNA polymerase complex|,DNA-dependent DNA replication|DNA-dependent DNA replication|histone H3 acetylation|,DNA-directed DNA polymerase activity|protein binding|sequence-specific DNA binding|protein heterodimerization activity|,7,-3.9,4.62,8,-2.7,4.42,-3.7,8.45,0.0219,-7.1,-1
ENSMUSG00000062866,PHACTR2,phosphatase and actin regulator 2,None,negative regulation of catalytic activity|,actin binding|protein phosphatase inhibitor activity|protein binding|,9,-3.3,5.61,9,-1.9,3.93,-3.1,8.44,0.022,-7.1,-0.6
ENSMUSG00000003360,DDX23,DEAD (Asp-Glu-Ala-Asp) box polypeptide 23,nucleus|nucleoplasm|U5 snRNP|mitochondrion|plasma membrane|extracellular vesicular exosome|catalytic step 2 spliceosome|,"cis assembly of pre-catalytic spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|ATP catabolic process|RNA splicing|gene expression|",ATP-dependent RNA helicase activity|protein binding|ATP binding|poly(A) RNA binding|,9,-3,2.81,10,-4.2,6.29,-3.4,8.43,0.0221,-7.9,-0.6
ENSMUSG00000093626,GM20654,N/A,None,None,None,0,0,0,1,6.5,8.61,6.5,8.42,0.0222,4.3,13
ENSMUSG00000068314,GM6899,predicted gene 6899,cellular_component|,biological_process|,molecular_function|,0,0,0,1,6.5,8.6,6.5,8.41,0.0223,4.3,13
ENSMUSG00000023781,HES7,hes family bHLH transcription factor 7,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|skeletal system development|somitogenesis|transcription, DNA-templated|Notch signaling pathway|mesoderm development|regulation of somitogenesis|post-anal tail morphogenesis|rhythmic process|",DNA binding|transcription factor binding|protein dimerization activity|,2,-3,2.94,3,-3.8,6.03,-3.7,8.39,0.0225,-7,-1.9
ENSMUSG00000025911,ADHFE1,"alcohol dehydrogenase, iron containing, 1",mitochondrion|mitochondrial matrix|,2-oxoglutarate metabolic process|molecular hydrogen transport|cellular metabolic process|small molecule metabolic process|oxidation-reduction process|,metal ion binding|hydroxyacid-oxoacid transhydrogenase activity|,10,-4.1,1.92,10,-6.1,7.33,-4.4,8.39,0.0225,-10.4,-0.6
ENSMUSG00000021149,GTPBP4,GTP binding protein 4,nucleus|nucleolus|cytoplasm|Golgi apparatus|membrane|nuclear membrane|perinuclear region of cytoplasm|,regulation of cyclin-dependent protein serine/threonine kinase activity|osteoblast differentiation|GTP catabolic process|negative regulation of DNA replication|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell migration|negative regulation of protein ubiquitination|negative regulation of collagen binding|ribosome biogenesis|protein stabilization|,GTPase activity|protein binding|GTP binding|poly(A) RNA binding|,8,3.2,7.56,6,-2.7,2.06,3.2,8.38,0.0225,-1.7,9
ENSMUSG00000020687,CDC27,cell division cycle 27,nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|spindle|cytosol|spindle microtubule|,mitotic cell cycle|metaphase/anaphase transition of mitotic cell cycle|mitotic spindle assembly checkpoint|cell proliferation|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,protein binding|protein phosphatase binding|,7,-3,4.65,5,-2.9,4.09,-3,8.37,0.0226,-7,5
ENSMUSG00000051257,TRAP1A,tumor rejection antigen P1A,nucleus|,None,None,10,-3,5.37,10,-2.1,3.83,-2.8,8.36,0.0226,-5.1,-0.6
ENSMUSG00000066149,CDC26,cell division cycle 26,nucleoplasm|anaphase-promoting complex|cytosol|,mitotic cell cycle|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,protein binding|,7,1.6,1.36,6,-3.6,7.81,-3.5,8.35,0.0228,-7.3,-1.2
ENSMUSG00000004099,DNMT1,DNA (cytosine-5-)-methyltransferase 1,nucleus|replication fork|centromeric heterochromatin|,"negative regulation of transcription from RNA polymerase II promoter|DNA methylation|transcription, DNA-templated|maintenance of DNA methylation|positive regulation of gene expression|gene silencing|chromatin modification|regulation of cell proliferation|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|cellular response to amino acid stimulus|C-5 methylation of cytosine|",DNA binding|chromatin binding|RNA binding|DNA (cytosine-5-)-methyltransferase activity|protein binding|transcription factor binding|zinc ion binding|methyl-CpG binding|DNA-methyltransferase activity|,10,-1.8,2.32,10,-3.9,7.73,-2.5,8.34,0.0228,-6.3,-1.1
ENSMUSG00000025616,USP16,ubiquitin specific peptidase 16,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|mitotic nuclear division|histone deubiquitination|monoubiquitinated histone H2A deubiquitination|positive regulation of transcription, DNA-templated|positive regulation of translational elongation|positive regulation of transcription from RNA polymerase II promoter|protein homotetramerization|histone H2A K63-linked deubiquitination|",transcription coactivator activity|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding|histone binding|ubiquitin binding|,9,-5.1,4.88,9,-2.4,5.13,-3,8.33,0.0229,-7.3,-1
ENSMUSG00000021758,DDX4,DEAD (Asp-Glu-Ala-Asp) box polypeptide 4,nucleus|cytoplasm|chromatoid body|perinuclear region of cytoplasm|pi-body|piP-body|,ATP catabolic process|male meiosis I|multicellular organismal development|spermatogenesis|sperm motility|regulation of protein localization|,nucleic acid binding|ATP binding|ATP-dependent helicase activity|,9,5.1,1.79,10,-3.9,7.73,-3.6,8.31,0.0231,-8,-0.9
ENSMUSG00000020737,HN1,hematological and neurological expressed 1,nucleus|,None,None,9,-6.3,3.22,10,-4.2,5.5,-4.4,8.3,0.0231,-10.1,-0.8
ENSMUSG00000020295,HBQ1A,"hemoglobin, theta 1A",cellular_component|,transport|biological_process|oxygen transport|,molecular_function|oxygen transporter activity|metal ion binding|,1,6.2,8.47,0,0,0,6.2,8.28,0.0233,4.1,13
ENSMUSG00000073063,HBQ1B,"hemoglobin, theta 1B",cellular_component|,transport|biological_process|oxygen transport|,molecular_function|oxygen transporter activity|metal ion binding|,1,6.2,8.47,0,0,0,6.2,8.28,0.0233,4.1,13
ENSMUSG00000026683,NUF2,"NUF2, NDC80 kinetochore complex component","chromosome, centromeric region|condensed chromosome kinetochore|nucleus|cytosol|membrane|Ndc80 complex|",mitotic cell cycle|chromosome segregation|mitotic nuclear division|,molecular_function|protein binding|,6,4.3,8.77,5,-1.7,1.48,4,8.26,0.0234,1.4,9.4
ENSMUSG00000032959,PEBP1,phosphatidylethanolamine binding protein 1,nucleus|cytoplasm|extracellular vesicular exosome|,negative regulation of endopeptidase activity|,serine-type endopeptidase inhibitor activity|protein binding|ATP binding|phosphatidylethanolamine binding|enzyme binding|protein kinase binding|poly(A) RNA binding|,10,6,5.54,10,5.2,3.26,5.5,8.24,0.0236,1.3,11.8
ENSMUSG00000023043,KRT18,keratin 18,nucleolus|cytoplasm|microtubule organizing center|intermediate filament|centriolar satellite|keratin filament|perinuclear region of cytoplasm|extracellular vesicular exosome|,cell cycle|anatomical structure morphogenesis|viral process|tumor necrosis factor-mediated signaling pathway|Golgi to plasma membrane CFTR protein transport|negative regulation of apoptotic process|intermediate filament cytoskeleton organization|extrinsic apoptotic signaling pathway|hepatocyte apoptotic process|,structural molecule activity|protein binding|poly(A) RNA binding|scaffold protein binding|,10,-2.7,4.07,10,-2.5,4.54,-2.6,8.23,0.0237,-5.2,-0.8
ENSMUSG00000030268,BCAT1,"branched chain amino-acid transaminase 1, cytosolic",mitochondrion|cytosol|,G1/S transition of mitotic cell cycle|cell proliferation|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|,branched-chain-amino-acid transaminase activity|identical protein binding|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity|,10,-2.4,1.58,10,-4.4,7.2,-3.6,8.22,0.0237,-8.4,-0.7
ENSMUSG00000038335,TSR1,"TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)",nucleolus|,ribosome assembly|,poly(A) RNA binding|,5,2.7,3.57,5,5.3,6.32,3.4,8.21,0.0238,1.2,10.2
ENSMUSG00000027454,GINS1,GINS complex subunit 1 (Psf1 homolog),nucleus|nucleoplasm|cytoplasm|,mitotic cell cycle|inner cell mass cell proliferation|DNA strand elongation involved in DNA replication|,None,8,-4.1,6.12,5,-2.4,3.35,-3.9,8.2,0.0238,-7.8,-0.8
ENSMUSG00000066979,BUB3,BUB3 mitotic checkpoint protein,kinetochore|condensed chromosome kinetochore|nucleus|cytosol|,mitotic sister chromatid segregation|mitotic cell cycle|mitotic spindle assembly checkpoint|meiotic nuclear division|attachment of spindle microtubules to kinetochore|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of chromosome segregation|spindle assembly checkpoint|,protein binding|,10,-0.9,1.04,10,-2.2,8.03,-1.8,8.2,0.0238,-4.3,-0.5
ENSMUSG00000030030,1700003E16RIK,RIKEN cDNA 1700003E16 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-5.8,8.38,-5.8,8.19,0.0239,-11,-3.1
ENSMUSG00000012443,KIF11,kinesin family member 11,spindle pole|cytoplasm|spindle|cytosol|kinesin complex|microtubule|spindle microtubule|membrane|,microtubule-based movement|spindle organization|mitotic spindle organization|mitotic nuclear division|mitotic centrosome separation|blood coagulation|metabolic process|metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class II|spindle assembly involved in mitosis|,microtubule motor activity|ATP binding|microtubule binding|protein kinase binding|protein complex binding|,4,0,0,5,4.7,10.1,4.5,8.19,0.0239,2.3,9.6
ENSMUSG00000033208,S100B,S100 calcium binding protein B,ruffle|extracellular region|extracellular space|nucleus|cytoplasm|cytoplasm|neuronal cell body|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,axonogenesis|central nervous system development|learning or memory|memory|cell proliferation|positive regulation of cell proliferation|regulation of cell shape|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of neuronal synaptic plasticity|astrocyte differentiation|response to glucocorticoid|response to methylmercury|long-term synaptic potentiation|cellular response to hypoxia|negative regulation of skeletal muscle cell differentiation|,calcium ion binding|protein binding|zinc ion binding|identical protein binding|protein homodimerization activity|protein homodimerization activity|S100 protein binding|tau protein binding|calcium-dependent protein binding|RAGE receptor binding|,1,6.2,8.37,0,0,0,6.2,8.18,0.024,4.1,13
ENSMUSG00000023505,CDCA3,cell division cycle associated 3,cellular_component|cytosol|,mitotic nuclear division|biological_process|protein ubiquitination|,molecular_function|,10,-4.9,10.4,10,5.5,4.21,-4.6,8.18,0.024,-11.9,-0.3
ENSMUSG00000020953,COCH,cochlin,proteinaceous extracellular matrix|extracellular vesicular exosome|,sensory perception of sound|regulation of cell shape|,protein binding|,10,-2.2,2.05,10,-2.5,6.47,-2.5,8.18,0.024,-5.7,-0.6
ENSMUSG00000060601,NR1H2,"nuclear receptor subfamily 1, group H, member 2",nucleus|nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|gene expression|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|positive regulation of lipid storage|negative regulation of cholesterol storage|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|cholesterol homeostasis|steroid hormone mediated signaling pathway|cellular lipid metabolic process|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|retinoic acid receptor signaling pathway|negative regulation of pinocytosis|positive regulation of lipoprotein lipase activity|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of high-density lipoprotein particle assembly|positive regulation of pancreatic juice secretion|positive regulation of secretion of lysosomal enzymes|regulation of cholesterol homeostasis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|DNA binding|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|apolipoprotein A-I receptor binding|retinoid X receptor binding|ATPase binding|,10,-3.6,7.23,10,-1.7,2.6,-3.3,8.15,0.0242,-7.2,-0.6
ENSMUSG00000054387,MDM4,"MDM4, p53 regulator",nucleus|,"negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|DNA damage response, signal transduction by p53 class mediator|negative regulation of protein catabolic process|negative regulation of apoptotic process|G0 to G1 transition|protein stabilization|negative regulation of cell cycle arrest|cellular response to hypoxia|",protein binding|zinc ion binding|enzyme binding|,8,-2.8,2.35,8,-3,6.05,-2.9,8.06,0.0248,-6.9,-1
ENSMUSG00000001855,NUP214,nucleoporin 214kDa,nucleus|nuclear pore|nucleoplasm|cytosol|focal adhesion|intracellular membrane-bounded organelle|,mitotic cell cycle|carbohydrate metabolic process|mRNA export from nucleus|protein import into nucleus|protein export from nucleus|mitotic nuclear envelope disassembly|hexose transport|gene expression|regulation of glucose transport|glucose transport|viral process|RNA metabolic process|mRNA metabolic process|cytokine-mediated signaling pathway|small molecule metabolic process|regulation of cell cycle|transmembrane transport|,transporter activity|nucleocytoplasmic transporter activity|protein binding|,9,7.3,6.97,9,3.2,4.22,6.9,8.05,0.0248,1.6,14.5
ENSMUSG00000022545,ERCC4,excision repair cross-complementation group 4,"nucleotide-excision repair complex|nucleotide-excision repair factor 1 complex|chromosome, telomeric region|nuclear chromosome, telomeric region|nucleus|nucleoplasm|transcription factor TFIID complex|","resolution of meiotic recombination intermediates|nucleotide-excision repair, DNA damage removal|telomere maintenance|double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA repair|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to UV|UV protection|telomere maintenance via telomere shortening|negative regulation of telomere maintenance|nucleotide-excision repair, DNA incision|nucleotide-excision repair involved in interstrand cross-link repair|",single-stranded DNA endodeoxyribonuclease activity|TFIID-class transcription factor binding|damaged DNA binding|single-stranded DNA binding|endodeoxyribonuclease activity|endodeoxyribonuclease activity|protein binding|protein C-terminus binding|structure-specific DNA binding|protein N-terminus binding|,10,-1.5,1.66,10,-4.7,8.54,-3.6,8.04,0.0249,-8.1,-1.4
ENSMUSG00000033170,CARD10,"caspase recruitment domain family, member 10",cytoplasm|CBM complex|,protein complex assembly|activation of NF-kappaB-inducing kinase activity|regulation of apoptotic process|,protein binding|receptor signaling complex scaffold activity|,10,0.9,0.663,10,-3.6,9.41,-3.5,8,0.0252,-8.1,-0.7
ENSMUSG00000033307,MIF,macrophage migration inhibitory factor (glycosylation-inhibiting factor),extracellular region|extracellular space|cytoplasm|cell surface|extracellular vesicular exosome|,"prostaglandin biosynthetic process|negative regulation of mature B cell apoptotic process|inflammatory response|cell surface receptor signaling pathway|cell aging|cell proliferation|negative regulation of gene expression|positive regulation of protein kinase A signaling|carboxylic acid metabolic process|DNA damage response, signal transduction by p53 class mediator|positive regulation of B cell proliferation|positive regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of cellular protein metabolic process|negative regulation of myeloid cell apoptotic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of phosphorylation|regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of MAP kinase activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|innate immune response|positive regulation of fibroblast proliferation|positive regulation of cytokine secretion|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of prostaglandin secretion involved in immune response|positive regulation of myeloid leukocyte cytokine production involved in immune response|protein homotrimerization|positive regulation of ERK1 and ERK2 cascade|negative regulation of cell cycle arrest|positive regulation of arachidonic acid secretion|negative regulation of cell aging|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of chemokine (C-X-C motif) ligand 2 production|",dopachrome isomerase activity|receptor binding|cytokine activity|cytokine receptor binding|protein binding|chemoattractant activity|phenylpyruvate tautomerase activity|,7,-3.6,4.34,10,-2.7,4.18,-3.4,7.98,0.0253,-6.5,-1.1
ENSMUSG00000020994,PNN,"pinin, desmosome associated protein",nucleus|cytoplasm|intermediate filament|plasma membrane|cell-cell junction|membrane|nuclear speck|desmosome|exon-exon junction complex|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|transcription, DNA-templated|regulation of transcription, DNA-templated|cell adhesion|",DNA binding|structural molecule activity|poly(A) RNA binding|,9,-2.3,0.791,8,-5.8,8.05,-3.9,7.97,0.0254,-10,-0.6
ENSMUSG00000037025,FOXA2,forkhead box A2,nucleus|cytoplasm|,"positive regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter by glucose|in utero embryonic development|ectoderm formation|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|adult locomotory behavior|negative regulation of epithelial to mesenchymal transition|chromatin modification|regulation of steroid metabolic process|cell differentiation in hindbrain|dorsal/ventral neural tube patterning|signal transduction involved in regulation of gene expression|regulation of blood coagulation|endocrine pancreas development|somite rostral/caudal axis specification|negative regulation of glucokinase activity|positive regulation of embryonic development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|cell development|neuron fate specification|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|regulation of insulin secretion involved in cellular response to glucose stimulus|connective tissue development|response to interleukin-6|dopaminergic neuron differentiation|primitive streak formation|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of gastrulation|negative regulation of detection of glucose|regulation of transcription from RNA polymerase II promoter involved in detection of glucose|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|protein domain specific binding|transcription regulatory region DNA binding|,1,2.2,1.82,1,-5.9,8.71,-5.8,7.91,0.0261,-11,-2.1
ENSMUSG00000000028,CDC45,cell division cycle 45,nucleus|nucleoplasm|cytoplasm|centrosome|,DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|,protein binding|,8,4.1,7.22,8,-4,5.82,3.8,7.9,0.0262,-5.7,9
ENSMUSG00000005732,RANBP1,RAN binding protein 1,nucleus|nuclear envelope|cytoplasm|centrosome|,spindle organization|signal transduction|viral process|positive regulation of GTPase activity|positive regulation of mitotic centrosome separation|intracellular transport|regulation of catalytic activity|,GDP-dissociation inhibitor activity|GTPase activator activity|Ran GTPase binding|,10,-6.1,8.71,10,-2.3,1.36,-5.8,7.88,0.0263,-10.2,-1.2
ENSMUSG00000028703,LRRC41,leucine rich repeat containing 41,membrane|,protein ubiquitination|,None,10,-3.6,4.79,10,-4.3,3.51,-3.6,7.84,0.0267,-8.2,-0.4
ENSMUSG00000044167,FOXO1,forkhead box O1,nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|blood vessel development|temperature homeostasis|cellular glucose homeostasis|transcription, DNA-templated|protein acetylation|apoptotic process|cellular response to DNA damage stimulus|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|cellular response to starvation|cellular response to starvation|positive regulation of autophagy|endocrine pancreas development|cellular response to insulin stimulus|negative regulation of stress-activated MAPK cascade|cellular response to oxidative stress|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|Fc-epsilon receptor signaling pathway|regulation of cell proliferation|positive regulation of apoptotic process|negative regulation of apoptotic process|innate immune response|fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of gluconeogenesis|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|cellular response to cold|cellular response to hyperoxia|cellular response to nitric oxide|regulation of energy homeostasis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|chromatin binding|protein binding|ubiquitin protein ligase binding|sequence-specific DNA binding|protein phosphatase 2A binding|,10,-4.7,4.05,10,-3.6,4.29,-4.5,7.83,0.0268,-9.1,-0.6
ENSMUSG00000019505,UBB,ubiquitin B,nucleoplasm|cytosol|plasma membrane|endosome membrane|endocytic vesicle membrane|,"G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|protein polyubiquitination|mitotic cell cycle|toll-like receptor signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|carbohydrate metabolic process|glycogen biosynthetic process|glucose metabolic process|DNA repair|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|Notch receptor processing|I-kappaB kinase/NF-kappaB signaling|JNK cascade|fibroblast growth factor receptor signaling pathway|gene expression|viral process|RNA metabolic process|mRNA metabolic process|endosomal transport|viral life cycle|virion assembly|viral protein processing|cytokine-mediated signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|ion transmembrane transport|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|small molecule metabolic process|innate immune response|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to hypoxia|intracellular transport of virus|apoptotic signaling pathway|",protein binding|,7,-2.1,1.5,7,-2.6,6.76,-2.4,7.82,0.0268,-5.7,-0.7
ENSMUSG00000015027,GALNS,galactosamine (N-acetyl)-6-sulfatase,lysosomal lumen|extracellular vesicular exosome|,carbohydrate metabolic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate catabolic process|small molecule metabolic process|,N-acetylgalactosamine-4-sulfatase activity|sulfuric ester hydrolase activity|N-acetylgalactosamine-6-sulfatase activity|metal ion binding|,9,1,0.132,10,-6.2,10.1,-5,7.82,0.0268,-11.1,-0.7
ENSMUSG00000030603,PSMC4,"proteasome (prosome, macropain) 26S subunit, ATPase, 4",proteasome complex|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|inclusion body|proteasome accessory complex|cytosolic proteasome complex|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|blastocyst development|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|proteolysis|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|ATP binding|ATPase activity|,8,-3.7,5.32,10,-2.6,3.42,-3.5,7.81,0.0269,-9,1.8
ENSMUSG00000004151,ETV1,ets variant 1,nucleus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|axon guidance|muscle organ development|mechanosensory behavior|cell differentiation|positive regulation of transcription from RNA polymerase II promoter|peripheral nervous system neuron development|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|protein binding|,10,-1.9,4.53,10,-2.8,3.71,-1.9,7.8,0.027,-4.6,-0.6
ENSMUSG00000028031,DKK2,dickkopf WNT signaling pathway inhibitor 2,extracellular space|,multicellular organismal development|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|,None,9,-1.3,1.5,9,-4.5,7.55,-1.5,7.79,0.027,-9.2,-0.4
ENSMUSG00000037262,KIN,Kin17 DNA and RNA binding protein,nucleus|cytoplasm|nuclear matrix|,DNA replication|DNA repair|DNA recombination|mRNA processing|cellular response to DNA damage stimulus|viral process|,DNA binding|double-stranded DNA binding|RNA binding|metal ion binding|,6,-3.5,5.76,8,-2.2,3.35,-3,7.76,0.0273,-7.5,-0.4
ENSMUSG00000038679,TRPS1,trichorhinophalangeal syndrome I,nucleus|,negative regulation of transcription from RNA polymerase II promoter|skeletal system development|chondrocyte differentiation|transcription from RNA polymerase II promoter|NLS-bearing protein import into nucleus|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of histone deacetylation|regulation of chondrocyte differentiation|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|,sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|,10,-3.1,5.09,10,-4,3.09,-3.2,7.74,0.0275,-7.8,-0.2
ENSMUSG00000026175,VIL1,villin 1,ruffle|cytoplasm|microvillus|lamellipodium|filopodium|actin filament bundle|filopodium tip|extracellular vesicular exosome|,protein complex assembly|epidermal growth factor receptor signaling pathway|regulation of cell shape|response to bacterium|positive regulation of epithelial cell migration|actin filament polymerization|actin filament depolymerization|positive regulation of cell migration|epithelial cell differentiation|positive regulation of actin filament bundle assembly|cellular response to hepatocyte growth factor stimulus|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament severing|regulation of actin nucleation|actin filament capping|cytoplasmic actin-based contraction involved in cell motility|regulation of wound healing|cellular response to epidermal growth factor stimulus|regulation of lamellipodium morphogenesis|,"calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|lysophosphatidic acid binding|identical protein binding|protein homodimerization activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|actin filament binding|",10,-3.9,3.2,10,-2.1,4.98,-2,7.74,0.0275,-5.7,-0.5
ENSMUSG00000028948,NOL9,nucleolar protein 9,nucleolus|membrane|,maturation of 5.8S rRNA|phosphorylation|,RNA binding|ATP binding|polynucleotide 5'-hydroxyl-kinase activity|,7,-2.8,1.8,7,4.5,10,4,7.72,0.0277,-3.2,10
ENSMUSG00000038429,USP5,ubiquitin specific peptidase 5 (isopeptidase T),lysosome|,ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|,cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|protein binding|omega peptidase activity|zinc ion binding|,4,4.1,5.07,5,-3.7,7.99,-3.6,7.72,0.0277,-9,4.4
ENSMUSG00000030413,PGLYRP1,peptidoglycan recognition protein 1,extracellular region|extracellular vesicular exosome|,pattern recognition receptor signaling pathway|immune response|peptidoglycan catabolic process|detection of bacterium|negative regulation of interferon-gamma production|negative regulation of natural killer cell differentiation involved in immune response|growth of symbiont in host|innate immune response|defense response to Gram-positive bacterium|,zinc ion binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|peptidoglycan binding|,9,1,0.16,10,-3.8,8.58,-3.9,7.71,0.0278,-10,2
ENSMUSG00000005378,WBSCR22,Williams Beuren syndrome chromosome region 22,cellular_component|nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|rRNA processing|biological_process|chromatin modification|methylation|methylation|",methyltransferase activity|poly(A) RNA binding|,9,-3.3,4.02,9,-2.1,4.42,-3.1,7.7,0.0278,-5.7,-0.7
ENSMUSG00000006736,TSPAN31,tetraspanin 31,integral component of plasma membrane|membrane|,positive regulation of cell proliferation|,None,10,-4.2,5.19,10,-1.6,3.23,-2.2,7.66,0.0282,-6.1,-0.6
ENSMUSG00000040731,EIF4H,eukaryotic translation initiation factor 4H,cytosol|membrane|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm|,translation|translational initiation|regulation of translational initiation|gene expression|viral process|sexual reproduction|cellular protein metabolic process|developmental growth|,"nucleotide binding|RNA binding|translation initiation factor activity|protein binding|translation factor activity, nucleic acid binding|poly(A) RNA binding|",10,-1.6,0.703,10,-4.7,8.28,-3.6,7.64,0.0283,-8.7,-0.6
ENSMUSG00000000776,POLR3D,"polymerase (RNA) III (DNA directed) polypeptide D, 44kDa",nuclear chromatin|nucleoplasm|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase III complex|cytosol|,transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus|,RNA polymerase III activity|DNA binding|chromatin binding|,10,-3.1,5.53,10,-3.1,2.42,-3.1,7.63,0.0285,-7.6,-0.3
ENSMUSG00000041849,CARD6,"caspase recruitment domain family, member 6",intracellular|,apoptotic process|regulation of apoptotic process|,None,8,-2.6,0.852,10,-4.7,7.31,-5.5,7.61,0.0286,-10.6,-1.1
ENSMUSG00000028681,PTCH2,patched 2,integral component of membrane|,signal transduction|signal transduction|epidermis development|hair cycle|negative regulation of smoothened signaling pathway|,smoothened binding|hedgehog receptor activity|hedgehog family protein binding|hedgehog family protein binding|,10,-2.7,4.35,10,-1.9,3.78,-2.6,7.61,0.0286,-7.9,2.2
ENSMUSG00000003378,GRIK5,"glutamate receptor, ionotropic, kainate 5",endoplasmic reticulum|plasma membrane|postsynaptic density|cell junction|dendrite|kainate selective glutamate receptor complex|presynaptic membrane|terminal bouton|perikaryon|postsynaptic membrane|,"protein retention in ER lumen|synaptic transmission|regulation of synaptic vesicle fusion to presynaptic membrane|ion transmembrane transport|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|receptor clustering|positive regulation of neuron apoptotic process|establishment of localization in cell|regulation of excitatory postsynaptic membrane potential|cellular response to glucose stimulus|",extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|SH3 domain binding|PDZ domain binding|identical protein binding|,0,0,0,1,6.1,7.71,6.1,7.52,0.0295,3.6,12
ENSMUSG00000036594,H2-AA,"histocompatibility 2, class II antigen A, alpha",lysosome|plasma membrane|external side of plasma membrane|membrane|membrane|integral component of membrane|MHC class II protein complex|,immune system process|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|response to interferon-gamma|negative regulation of T cell proliferation|positive regulation of T cell differentiation|antigen processing and presentation of peptide antigen|,protein binding|peptide antigen binding|protein heterodimerization activity|,10,-6.5,4.17,10,-4.5,4.15,-6.3,7.5,0.0297,-11.6,-0.4
ENSMUSG00000027193,API5,apoptosis inhibitor 5,nucleus|spliceosomal complex|cytoplasm|membrane|,apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of fibroblast apoptotic process|,protein binding|fibroblast growth factor binding|poly(A) RNA binding|,9,4.9,7.88,9,-1.8,2.35,4.5,7.49,0.0298,-1.7,12
ENSMUSG00000026628,ATF3,activating transcription factor 3,nucleus|nucleoplasm|nucleolus|,"gluconeogenesis|transcription, DNA-templated|activation of signaling protein activity involved in unfolded protein response|positive regulation of cell proliferation|endoplasmic reticulum unfolded protein response|skeletal muscle cell differentiation|cellular protein metabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|identical protein binding|,9,-1.7,3.05,10,-2.2,4.88,-2,7.47,0.03,-4.4,-0.4
ENSMUSG00000026435,SLC45A3,"solute carrier family 45, member 3",integral component of membrane|,transmembrane transport|,None,10,-4.1,5.82,10,-2.4,2.2,-3.4,7.46,0.0301,-7.2,-0.7
ENSMUSG00000039982,DTX4,"deltex 4, E3 ubiquitin ligase",cytosol|,Notch signaling pathway|protein ubiquitination|regulation of type I interferon production|positive regulation of type I interferon production|innate immune response|,zinc ion binding|ligase activity|,10,-6.7,10.6,10,-0.2,0.0618,-6.5,7.45,0.0301,-11.8,-0.9
ENSMUSG00000053641,DENND4A,DENN/MADD domain containing 4A,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of Rab GTPase activity|",DNA binding|Rab guanyl-nucleotide exchange factor activity|,10,0,0,10,-5.2,9.09,-5.2,7.43,0.0303,-11,-1.4
ENSMUSG00000021116,EIF2S1,"eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa",nucleus|cytosol|polysome|eukaryotic translation initiation factor 2 complex|eukaryotic translation initiation factor 2B complex|cytoplasmic stress granule|membrane|extracellular vesicular exosome|,translation|translational initiation|activation of signaling protein activity involved in unfolded protein response|gene expression|endoplasmic reticulum unfolded protein response|regulation of translational initiation in response to stress|cellular protein metabolic process|protein autophosphorylation|,translation initiation factor activity|protein binding|ribosome binding|poly(A) RNA binding|,8,-3.3,5.03,8,-3.7,2.75,-3.4,7.4,0.0306,-8,5.5
ENSMUSG00000031858,MAU2,MAU2 sister chromatid cohesion factor,chromatin|nucleus|nucleoplasm|nucleoplasm|SMC loading complex|SMC loading complex|,mitotic cell cycle|maintenance of mitotic sister chromatid cohesion|,protein binding|protein N-terminus binding|,10,-4.7,1.63,10,-4.1,6.15,-4.6,7.39,0.0307,-9.2,-0.6
ENSMUSG00000045382,CXCR4,chemokine (C-X-C motif) receptor 4,cytoplasm|lysosome|early endosome|late endosome|plasma membrane|plasma membrane|external side of plasma membrane|cell surface|integral component of membrane|cytoplasmic membrane-bounded vesicle|cell junction|growth cone|cell leading edge|cytoplasmic vesicle|extracellular vesicular exosome|,activation of MAPK activity|patterning of blood vessels|response to hypoxia|ameboidal cell migration|neuron migration|dendritic cell chemotaxis|apoptotic process|inflammatory response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|germ cell development|brain development|motor neuron axon guidance|germ cell migration|response to virus|viral process|calcium-mediated signaling|entry into host cell|regulation of cell migration|T cell proliferation|neutrophil activation|myelin maintenance|positive regulation of oligodendrocyte differentiation|regulation of chemotaxis|neural precursor cell proliferation|chemokine-mediated signaling pathway|chemokine-mediated signaling pathway|cellular response to cytokine stimulus|,virus receptor activity|actin binding|G-protein coupled receptor activity|protein binding|coreceptor activity|C-X-C chemokine receptor activity|cytokine binding|ubiquitin protein ligase binding|myosin light chain binding|ubiquitin binding|,10,-2,1.84,10,-1.9,5.84,-2,7.38,0.0308,-5.5,-0.4
ENSMUSG00000032997,CHPF,chondroitin polymerizing factor,Golgi membrane|mitochondrial matrix|cytosol|integral component of membrane|Golgi cisterna membrane|,carbohydrate metabolic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|,protein binding|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|,9,2.4,5.54,10,1.7,2.57,2,7.37,0.0309,0.3,5.9
ENSMUSG00000024610,CD74,"CD74 molecule, major histocompatibility complex, class II invariant chain",Golgi membrane|intracellular|lysosomal membrane|multivesicular body|vacuole|plasma membrane|external side of plasma membrane|cell surface|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|trans-Golgi network membrane|macrophage migration inhibitory factor receptor complex|NOS2-CD74 complex|MHC class II protein complex|lysosomal lumen|extracellular vesicular exosome|integral component of lumenal side of endoplasmic reticulum membrane|,"activation of MAPK activity|prostaglandin biosynthetic process|positive regulation of cytokine-mediated signaling pathway|positive regulation of dendritic cell antigen processing and presentation|negative regulation of peptide secretion|positive regulation of type 2 immune response|negative regulation of mature B cell apoptotic process|protein complex assembly|intracellular protein transport|defense response|signal transduction|cell proliferation|immunoglobulin mediated immune response|antigen processing and presentation of endogenous antigen|antigen processing and presentation of exogenous peptide antigen via MHC class II|positive regulation of B cell proliferation|macrophage migration inhibitory factor signaling pathway|regulation of macrophage activation|negative regulation of apoptotic process|negative regulation of DNA damage response, signal transduction by p53 class mediator|T cell selection|positive thymic T cell selection|negative thymic T cell selection|negative regulation of T cell differentiation|positive regulation of T cell differentiation|positive regulation of fibroblast proliferation|positive regulation of peptidyl-tyrosine phosphorylation|chaperone mediated protein folding requiring cofactor|positive regulation of macrophage cytokine production|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of neutrophil chemotaxis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of chemokine (C-X-C motif) ligand 2 production|","beta-amyloid binding|cytokine receptor activity|protein binding|cytokine binding|MHC class II protein complex binding|macrophage migration inhibitory factor binding|MHC class II protein binding|MHC class II protein binding|MHC class II protein binding, via antigen binding groove|identical protein binding|protein binding involved in protein folding|nitric-oxide synthase binding|",1,-4.1,2.29,1,6.3,8.2,6.3,7.37,0.0309,0.7,13
ENSMUSG00000036427,GPI1,glucose phosphate isomerase 1,extracellular region|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|membrane|neuron projection|ciliary membrane|extracellular vesicular exosome|,angiogenesis|in utero embryonic development|mesoderm formation|carbohydrate metabolic process|gluconeogenesis|glycolytic process|glycolytic process|methylglyoxal biosynthetic process|erythrocyte homeostasis|glucose homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|aldehyde catabolic process|glucose 6-phosphate metabolic process|glycolytic process through glucose-6-phosphate|,glucose-6-phosphate isomerase activity|glucose-6-phosphate isomerase activity|glucose-6-phosphate isomerase activity|cytokine activity|protein binding|growth factor activity|isomerase activity|intramolecular transferase activity|monosaccharide binding|,10,-4.3,3.93,9,-4.1,3.8,-4.3,7.37,0.0309,-8.3,-0.5
ENSMUSG00000024517,GRP,gastrin-releasing peptide,extracellular region|extracellular space|,signal transduction|neuropeptide signaling pathway|,receptor binding|neuropeptide hormone activity|,10,-3.4,9.3,10,-0.5,0.254,-3.1,7.35,0.0313,-6.9,-0.5
ENSMUSG00000022881,RFC4,"replication factor C (activator 1) 4, 37kDa",nucleoplasm|DNA replication factor C complex|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|phosphatidylinositol-mediated signaling|",DNA binding|protein binding|ATP binding|nucleoside-triphosphatase activity|,6,-3,2.11,7,-2.5,5.68,-2.7,7.35,0.0313,-6.6,-0.6
ENSMUSG00000027719,ADAD1,adenosine deaminase domain containing 1 (testis-specific),nucleus|,RNA processing|multicellular organismal development|spermatid development|,RNA binding|adenosine deaminase activity|,10,1.4,0.899,9,3.1,7.39,2.5,7.35,0.0313,0.1,7.5
ENSMUSG00000057219,ARMC7,armadillo repeat containing 7,cytoplasm|,None,None,1,5.8,7.53,0,0,0,5.8,7.34,0.0314,3.6,12
ENSMUSG00000021147,WDR37,WD repeat domain 37,None,None,None,9,-3.3,6.67,10,-2.9,0.941,-3.3,7.33,0.0315,-8.1,-0.8
ENSMUSG00000022476,POLR3H,polymerase (RNA) III (DNA directed) polypeptide H (22.9kD),nucleus|nucleoplasm|nucleoplasm|DNA-directed RNA polymerase III complex|centrosome|cytosol|intracellular membrane-bounded organelle|,nucleobase-containing compound metabolic process|transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|innate immune response|defense response to virus|,RNA polymerase III activity|DNA binding|DNA-directed RNA polymerase activity|,4,-5.3,3.17,2,-4.2,4.87,-5.1,7.33,0.0315,-10.5,-1.8
ENSMUSG00000033020,POLR2F,polymerase (RNA) II (DNA directed) polypeptide F,"nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|nucleolus|DNA-directed RNA polymerase I complex|cytosol|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|RNA splicing|gene expression|viral process|positive regulation of type I interferon production|innate immune response|positive regulation of viral transcription|",RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|DNA binding|,9,-4,3.3,9,-2.8,4.44,-3.9,7.31,0.0316,-8.4,-0.6
ENSMUSG00000031712,IL15,interleukin 15,extracellular region|extracellular space|nucleus|cytoplasm|endosome|Golgi apparatus|integral component of plasma membrane|cell surface|membrane|,natural killer cell differentiation|NK T cell proliferation|inflammatory response|immune response|signal transduction|cell-cell signaling|aging|positive regulation of cell proliferation|skeletal muscle atrophy|hyaluronan metabolic process|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of natural killer cell differentiation|positive regulation of tissue remodeling|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|extrathymic T cell selection|regulation of T cell differentiation|cell maturation|lymph node development|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|positive regulation of inflammatory response|positive regulation of immune response|cellular response to vitamin D|,cytokine activity|cytokine receptor binding|protein binding|,9,3.4,8.58,9,1.6,0.529,3.1,7.31,0.0316,0.8,8.7
ENSMUSG00000030591,PSMD8,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 8",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",None,8,6.3,3.99,7,-3.5,3.65,-3.5,7.3,0.0316,-10,6.1
ENSMUSG00000004667,POLR2E,"polymerase (RNA) II (DNA directed) polypeptide E, 25kDa","nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|RNA splicing|gene expression|viral process|positive regulation of type I interferon production|innate immune response|positive regulation of viral transcription|",RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|DNA binding|DNA-directed RNA polymerase activity|protein binding|,6,-3.9,9.75,7,2.4,1.8,-3.8,7.27,0.032,-8.9,-1.1
ENSMUSG00000040282,BC052040,cDNA sequence BC052040,cellular_component|,biological_process|,molecular_function|,10,-3.5,9.06,9,-1.1,0.744,-3.3,7.26,0.032,-6.2,-0.7
ENSMUSG00000028312,SMC2,structural maintenance of chromosomes 2,nuclear chromosome|condensed chromosome|condensin complex|nucleus|nucleoplasm|cytoplasm|cytosol|extracellular vesicular exosome|,mitotic cell cycle|mitotic chromosome condensation|meiotic chromosome condensation|meiotic chromosome segregation|kinetochore organization|,protein binding|ATP binding|protein heterodimerization activity|,4,-4.3,2.61,5,-3.4,5.26,-3.8,7.24,0.0322,-8.8,-1
ENSMUSG00000070501,BC094916,cDNA sequence BC094916,nucleus|nucleolus|cytoplasm|membrane|,biological_process|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,10,2.6,5.37,10,2.9,2.2,2.8,7.23,0.0323,0.5,6.1
ENSMUSG00000036948,BC037034,cDNA sequence BC037034,cellular_component|,biological_process|,molecular_function|,10,-5.5,2.98,10,-3,5.33,-3.3,7.21,0.0324,-8.2,-0.6
ENSMUSG00000001672,MARVELD3,MARVEL domain containing 3,tight junction|integral component of membrane|cytoplasmic vesicle|,cell-cell junction organization|tight junction assembly|,protein binding|,1,5.8,7.37,0,0,0,5.8,7.19,0.0326,3.5,12
ENSMUSG00000068039,TCP1,t-complex 1,pericentriolar material|acrosomal vesicle|zona pellucida receptor complex|nuclear heterochromatin|Golgi apparatus|centrosome|cytosol|chaperonin-containing T-complex|microtubule|cell body|extracellular vesicular exosome|,protein folding|tubulin complex assembly|binding of sperm to zona pellucida|cellular protein metabolic process|'de novo' posttranslational protein folding|,protein binding|ATP binding|poly(A) RNA binding|unfolded protein binding|,6,5.6,8.86,5,-2.3,1.92,5.5,7.18,0.0327,-0.7,12
ENSMUSG00000031216,STARD8,StAR-related lipid transfer (START) domain containing 8,cytosol|focal adhesion|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|lipid binding|,10,-2.3,1.96,10,-4.2,6.66,-3,7.18,0.0327,-7.9,-0.4
ENSMUSG00000001403,UBE2C,ubiquitin-conjugating enzyme E2C,nucleoplasm|anaphase-promoting complex|cytosol|,mitotic cell cycle|ubiquitin-dependent protein catabolic process|cell cycle|spindle organization|mitotic spindle assembly checkpoint|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|protein ubiquitination|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of exit from mitosis|phosphatidylinositol-mediated signaling|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|activation of anaphase-promoting complex activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|,10,-1.9,0.408,9,-4.4,7.78,-4.1,7.16,0.0329,-7.9,-1.7
ENSMUSG00000000489,PDGFB,platelet-derived growth factor beta polypeptide,Golgi membrane|extracellular region|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|cell surface|basolateral plasma membrane|platelet alpha granule lumen|,"response to hypoxia|embryonic placenta development|positive regulation of endothelial cell proliferation|monocyte chemotaxis|platelet degranulation|positive regulation of glomerular filtration|DNA replication|protein phosphorylation|substrate-dependent cell migration|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|heart development|blood coagulation|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|response to wounding|response to wounding|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|cell growth|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|cell projection assembly|actin cytoskeleton organization|platelet activation|extracellular matrix organization|positive regulation of cell migration|negative regulation of cell migration|positive regulation of protein autophosphorylation|activation of protein kinase activity|activation of protein kinase B activity|response to estradiol|response to insulin|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|paracrine signaling|Fc-epsilon receptor signaling pathway|response to drug|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of DNA replication|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of mitosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|blood vessel morphogenesis|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of chemotaxis|positive regulation of cell division|cell chemotaxis|branching involved in salivary gland morphogenesis|epithelial cell proliferation involved in salivary gland morphogenesis|positive regulation of protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|cellular response to growth factor stimulus|cellular response to mycophenolic acid|positive regulation of glomerular mesangial cell proliferation|metanephric glomerular mesangial cell development|metanephric glomerular mesangial cell proliferation involved in metanephros development|metanephric glomerular endothelium development|reactive oxygen species metabolic process|positive regulation of calcium ion import|positive regulation of hyaluronan biosynthetic process|positive regulation of reactive oxygen species metabolic process|positive regulation of DNA biosynthetic process|positive regulation of metanephric mesenchymal cell migration|",platelet-derived growth factor receptor binding|platelet-derived growth factor receptor binding|platelet-derived growth factor receptor binding|platelet-derived growth factor receptor binding|protein binding|collagen binding|growth factor activity|superoxide-generating NADPH oxidase activator activity|chemoattractant activity|identical protein binding|protein homodimerization activity|protein heterodimerization activity|platelet-derived growth factor binding|,10,4.6,4.72,10,2.5,3.51,3.5,7.14,0.0331,0.4,8.1
ENSMUSG00000047146,TET1,tet methylcytosine dioxygenase 1,nucleus|,"inner cell mass cell differentiation|transcription, DNA-templated|protein O-linked glycosylation|chromatin modification|stem cell maintenance|regulation of DNA methylation|positive regulation of transcription from RNA polymerase II promoter|oxidation-reduction process|DNA demethylation|negative regulation of methylation-dependent chromatin silencing|",iron ion binding|zinc ion binding|structure-specific DNA binding|methylcytosine dioxygenase activity|methylcytosine dioxygenase activity|,10,-0.6,0.319,10,-4.2,8.05,-4.2,7.13,0.0332,-8.6,-0.6
ENSMUSG00000029313,AFF1,"AF4/FMR2 family, member 1",nucleus|,"positive regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|protein binding|,9,-3.6,3.06,9,6.9,10.3,6.9,7.13,0.0332,-4.4,14
ENSMUSG00000030337,VAMP1,vesicle-associated membrane protein 1 (synaptobrevin 1),mitochondrial outer membrane|integral component of plasma membrane|cell junction|endocytic vesicle membrane|synaptic vesicle membrane|neuron projection|,synaptic transmission|neurotransmitter secretion|vesicle-mediated transport|,protein binding|,10,-6.6,2.03,10,-3.8,5.94,-4.3,7.12,0.0332,-10.3,-0.5
ENSMUSG00000032254,KIF23,kinesin family member 23,nucleus|nucleoplasm|centrosome|spindle|cytosol|kinesin complex|microtubule|midbody|intercellular bridge|mitotic spindle|centralspindlin complex|,mitotic spindle elongation|mitotic cell cycle|cytokinesis|microtubule-based movement|blood coagulation|metabolic process|metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class II|positive regulation of cytokinesis|spindle midzone assembly involved in mitosis|,microtubule motor activity|protein binding|ATP binding|microtubule binding|,9,-7.7,6.68,9,-1.2,1.19,-1.9,7.11,0.0334,-13.4,-0.4
ENSMUSG00000028933,XRCC2,X-ray repair complementing defective repair in Chinese hamster cells 2,replication fork|cytoplasm|centrosome|Rad51B-Rad51C-Rad51D-XRCC2 complex|,mitotic cell cycle|double-strand break repair via homologous recombination|in utero embryonic development|ATP catabolic process|DNA repair|meiotic nuclear division|response to X-ray|response to gamma radiation|strand invasion|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|centrosome organization|,four-way junction DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|,10,-2.2,2.61,10,-3,5.04,-2.5,7.11,0.0334,-7.1,-0.3
ENSMUSG00000039067,PSMD7,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 7",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|membrane|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|,6,1.9,2.01,8,4.1,6,2.8,7.11,0.0334,0.4,8.3
ENSMUSG00000019470,XAB2,XPA binding protein 2,nucleus|nucleoplasm|membrane|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|blastocyst development|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription, DNA-templated|",protein binding|,6,-4.7,3.76,9,-2.7,5.08,-4.1,7.11,0.0334,-8,-1
ENSMUSG00000029828,4921507P07RIK,RIKEN cDNA 4921507P07 gene,cellular_component|,biological_process|,molecular_function|,10,0.1,0.00261,10,-4.9,7.55,-4.2,7.09,0.0337,-10.5,-0.5
ENSMUSG00000026966,SSNA1,Sjogren syndrome nuclear autoantigen 1,nucleus|centrosome|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|intraciliary transport|ciliary receptor clustering involved in smoothened signaling pathway|,identical protein binding|,10,-2.7,1.03,9,3.4,8.29,3.3,7.07,0.0338,0.6,6.9
ENSMUSG00000031906,SMPD3,"sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)",Golgi cis cisterna|Golgi membrane|plasma membrane|,sphingolipid metabolic process|sphingomyelin catabolic process|glycosphingolipid metabolic process|cell cycle|multicellular organismal development|peptide hormone secretion|small molecule metabolic process|,sphingomyelin phosphodiesterase activity|metal ion binding|,10,-4.8,7.84,10,4,7.8,-4.7,7.07,0.0338,-13.9,6.4
ENSMUSG00000022673,MCM4,minichromosome maintenance complex component 4,nucleus|nucleus|nucleoplasm|membrane|MCM complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|,single-stranded DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|,9,-4.5,6.95,8,-1.5,2.63,-4.3,7.07,0.0338,-8.4,-0.5
ENSMUSG00000027720,IL2,interleukin 2,extracellular region|extracellular space|,negative regulation of protein phosphorylation|negative regulation of B cell apoptotic process|immune response|cell adhesion|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G-protein coupled receptor signaling pathway|cell-cell signaling|positive regulation of cell proliferation|natural killer cell activation|T cell differentiation|positive regulation of cell growth|positive regulation of B cell proliferation|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of tissue remodeling|positive regulation of activated T cell proliferation|positive regulation of tyrosine phosphorylation of Stat5 protein|negative regulation of apoptotic process|positive regulation of regulatory T cell differentiation|negative regulation of heart contraction|positive regulation of transcription from RNA polymerase II promoter|regulation of T cell homeostatic proliferation|positive regulation of isotype switching to IgG isotypes|negative regulation of lymphocyte proliferation|negative regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of immunoglobulin secretion|positive regulation of dendritic spine development|extrinsic apoptotic signaling pathway in absence of ligand|,cytokine activity|interleukin-2 receptor binding|interleukin-2 receptor binding|growth factor activity|kinase activator activity|carbohydrate binding|kappa-type opioid receptor binding|glycosphingolipid binding|,9,-3,4.57,10,-3.9,2.93,-3.1,7.06,0.034,-8,2.4
ENSMUSG00000037405,ICAM1,intercellular adhesion molecule 1,immunological synapse|extracellular space|plasma membrane|integral component of plasma membrane|external side of plasma membrane|membrane|extracellular vesicular exosome|,ovarian follicle development|regulation of leukocyte mediated cytotoxicity|response to amphetamine|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|T cell antigen processing and presentation|positive regulation of cellular extravasation|cell adhesion|heterophilic cell-cell adhesion|leukocyte cell-cell adhesion|cell aging|regulation of cell shape|response to virus|response to ionizing radiation|response to sulfur dioxide|response to organic cyclic compound|cytokine-mediated signaling pathway|membrane to membrane docking|regulation of cell adhesion|extracellular matrix organization|positive regulation of actin filament polymerization|cellular response to nutrient levels|positive regulation of Rho GTPase activity|cell adhesion mediated by integrin|response to gonadotropin|response to drug|response to amino acid|adhesion of symbiont to host|positive regulation of nitric oxide biosynthetic process|response to ethanol|positive regulation of vasoconstriction|response to copper ion|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|leukocyte migration|positive regulation of NF-kappaB transcription factor activity|negative regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to alkaloid|cellular response to glucose stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to hypoxia|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of endothelial cell apoptotic process|,virus receptor activity|receptor activity|transmembrane signaling receptor activity|integrin binding|integrin binding|protein binding|,8,-1.4,2.37,10,-2.5,5.49,-2.2,7.06,0.034,-5.6,-0.5
ENSMUSG00000025912,MYBL1,v-myb avian myeloblastosis viral oncogene homolog-like 1,nucleus|,"transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|,10,0,0,10,-4.1,7.43,-4,7.03,0.0343,-8.7,-1.4
ENSMUSG00000019738,POLR2I,"polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa","nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|","mRNA splicing, via spliceosome|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA splicing|gene expression|viral process|positive regulation of viral transcription|",DNA binding|DNA-directed RNA polymerase activity|zinc ion binding|,8,-3.6,6.42,9,3.6,9.59,3.5,7.02,0.0343,-4.4,8
ENSMUSG00000025857,HEATR2,HEAT repeat containing 2,cytoplasm|,None,None,10,-2.4,3.92,10,-1.7,3.66,-2.2,7.01,0.0345,-5.2,-0.2
ENSMUSG00000038612,MCL1,myeloid cell leukemia 1,nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|mitochondrial matrix|cytosol|membrane|membrane|integral component of membrane|Bcl-2 family protein complex|,cell fate determination|multicellular organismal development|intrinsic apoptotic signaling pathway in response to DNA damage|apoptotic mitochondrial changes|cellular homeostasis|response to cytokine|protein transmembrane transport|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|negative regulation of execution phase of apoptosis|negative regulation of anoikis|regulation of response to DNA damage stimulus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein binding|protein channel activity|protein homodimerization activity|protein heterodimerization activity|BH3 domain binding|,7,3.5,9.35,6,-1.9,1.77,3.4,7.01,0.0345,-2.1,8
ENSMUSG00000021470,ERCC6L2,excision repair cross-complementation group 6-like 2,nucleus|mitochondrion|microtubule organizing center|,ATP catabolic process|DNA repair|,DNA binding|ATP binding|ATP-dependent helicase activity|,1,5.7,7.19,0,0,0,5.7,7,0.0345,3.4,12
ENSMUSG00000003051,ELF3,"E74-like factor 3 (ets domain transcription factor, epithelial-specific )",nucleus|cytoplasm|,"blastocyst development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|inflammatory response|multicellular organismal development|epidermis development|extracellular matrix organization|epithelial cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|mammary gland involution|",sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|sequence-specific DNA binding|,2,4,4.13,1,3.3,3.35,3.9,7,0.0345,-0.4,9
ENSMUSG00000031004,MKI67,marker of proliferation Ki-67,"chromosome, centromeric region|condensed chromosome|nucleus|nucleolus|cytoplasm|membrane|",DNA metabolic process|meiotic nuclear division|cell proliferation|response to organic cyclic compound|hyaluronan metabolic process|organ regeneration|cellular response to heat|,protein binding|ATP binding|protein C-terminus binding|poly(A) RNA binding|,10,-3.6,1.37,10,-2,6.14,-1.9,6.98,0.0347,-5.6,-0.3
ENSMUSG00000002835,CHAF1A,"chromatin assembly factor 1, subunit A (p150)",nuclear chromatin|CAF-1 complex|protein complex|,"DNA replication|DNA repair|DNA replication-dependent nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|cell cycle|chromatin assembly|",chromatin binding|protein binding|identical protein binding|unfolded protein binding|chromo shadow domain binding|,9,-1.2,0.547,10,-2.9,7.28,-2.8,6.98,0.0347,-5.3,-0.5
ENSMUSG00000032006,PDGFD,platelet derived growth factor D,Golgi membrane|extracellular region|endoplasmic reticulum lumen|extracellular vesicular exosome|,multicellular organismal development|platelet-derived growth factor receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|cellular response to amino acid stimulus|,platelet-derived growth factor receptor binding|growth factor activity|,10,-2.2,1.37,10,-4.2,6.63,-4.1,6.97,0.0348,-9,-0.4
ENSMUSG00000038489,POLR2L,"polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa","nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription from RNA polymerase I promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|RNA splicing|gene expression|viral process|positive regulation of type I interferon production|innate immune response|positive regulation of viral transcription|",RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|DNA binding|DNA-directed RNA polymerase activity|zinc ion binding|,3,-3.2,0.761,3,-4.3,6.71,-4.2,6.95,0.035,-8,-2
ENSMUSG00000078350,SMIM1,small integral membrane protein 1 (Vel blood group),integral component of membrane|extracellular vesicular exosome|,None,None,2,3.1,7.13,0,0,0,3.1,6.95,0.035,1.5,7
ENSMUSG00000021779,THRB,"thyroid hormone receptor, beta",nucleus|nucleoplasm|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|sensory perception of sound|negative regulation of female receptivity|regulation of heart contraction|female courtship behavior|organ morphogenesis|gene expression|intracellular receptor signaling pathway|intracellular receptor signaling pathway|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription from RNA polymerase II promoter|Type I pneumocyte differentiation|",DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|thyroid hormone receptor activity|protein binding|zinc ion binding|enzyme binding|chromatin DNA binding|sequence-specific DNA binding|thyroid hormone binding|,10,-2.2,2.73,10,-2.1,4.52,-2.1,6.91,0.0357,-5.5,-0.2
ENSMUSG00000027716,TRPC3,"transient receptor potential cation channel, subfamily C, member 3",plasma membrane|integral component of plasma membrane|,calcium ion transport|axon guidance|blood coagulation|phototransduction|positive regulation of calcium ion transport into cytosol|platelet activation|response to ATP|ion transmembrane transport|response to calcium ion|transmembrane transport|calcium ion transmembrane transport|calcium ion transmembrane transport|,"calcium channel activity|protein binding|store-operated calcium channel activity|inositol 1,4,5 trisphosphate binding|",9,2,3.22,10,-2.5,4.45,-2.7,6.89,0.036,-6.5,4.4
ENSMUSG00000045237,1110012L19RIK,RIKEN cDNA 1110012L19 gene,cellular_component|,biological_process|,molecular_function|,2,5.3,7.06,0,0,0,5.3,6.87,0.0362,2.6,11
ENSMUSG00000070031,SP140,SP140 nuclear body protein,nucleus|nuclear envelope|nucleoplasm|cytoplasm|,"regulation of transcription, DNA-templated|defense response|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|,0,0,0,1,5.9,7.05,5.9,6.87,0.0362,3.3,12
ENSMUSG00000022871,FETUB,fetuin B,extracellular space|,single fertilization|binding of sperm to zona pellucida|biological_process|negative regulation of endopeptidase activity|,molecular_function|cysteine-type endopeptidase inhibitor activity|metalloendopeptidase inhibitor activity|,1,5.7,7.04,0,0,0,5.7,6.85,0.0364,3.4,12
ENSMUSG00000002055,SPAG5,sperm associated antigen 5,kinetochore|condensed chromosome kinetochore|spindle pole|cytoplasm|microtubule organizing center|spindle microtubule|midbody|microtubule plus-end|mitotic spindle|,mitotic sister chromatid segregation|cell cycle|spindle organization|spindle organization|chromosome segregation|phosphatidylinositol-mediated signaling|regulation of attachment of spindle microtubules to kinetochore|,protein binding|,9,-4,2.6,9,-4.2,4.57,-4,6.84,0.0366,-9.1,-0.4
ENSMUSG00000013523,BCAS1,breast carcinoma amplified sequence 1,cytoplasm|,None,None,9,-1.5,5.26,10,-1.8,1.9,-1.6,6.82,0.0368,-10.8,1.8
ENSMUSG00000030772,DKK3,dickkopf WNT signaling pathway inhibitor 3,extracellular space|,"anatomical structure morphogenesis|Wnt signaling pathway|adrenal gland development|negative regulation of aldosterone biosynthetic process|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|negative regulation of cortisol biosynthetic process|",None,10,-0.1,0.0123,10,-3.5,9.38,-3.3,6.81,0.0369,-8,-0.3
ENSMUSG00000020654,ADCY3,adenylate cyclase 3,cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|cilium|membrane|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|sensory perception of smell|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|calmodulin binding|ATP binding|metal ion binding|,8,-2.8,2,9,-3.4,5.27,-3,6.81,0.0369,-8.3,-0.1
ENSMUSG00000025364,PA2G4,"proliferation-associated 2G4, 38kDa",nucleus|nucleolus|cytoplasm|membrane|ribonucleoprotein complex|extracellular vesicular exosome|,"transcription, DNA-templated|rRNA processing|regulation of translation|cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-templated|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|ubiquitin protein ligase binding|poly(A) RNA binding|,10,-3.4,5.66,10,-1.8,2.71,-2.2,6.8,0.0371,-6.6,0.1
ENSMUSG00000031980,AGT,"angiotensinogen (serpin peptidase inhibitor, clade A, member 8)",extracellular region|extracellular region|extracellular space|extracellular space|extracellular space|extracellular vesicular exosome|blood microparticle|,"ovarian follicle rupture|regulation of cell growth|blood vessel development|branching involved in ureteric bud morphogenesis|positive regulation of cytokine production|kidney development|blood vessel remodeling|angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure|renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure|angiotensin maturation|regulation of blood volume by renin-angiotensin|renin-angiotensin regulation of aldosterone production|regulation of renal output by angiotensin|regulation of blood vessel size by renin-angiotensin|renal system process|angiotensin-mediated drinking behavior|positive regulation of extracellular matrix constituent secretion|cellular sodium ion homeostasis|cell-matrix adhesion|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|phospholipase C-activating G-protein coupled receptor signaling pathway|activation of phospholipase C activity|activation of NF-kappaB-inducing kinase activity|nitric oxide mediated signal transduction|cell-cell signaling|aging|excretion|establishment of blood-nerve barrier|negative regulation of cell proliferation|response to cold|response to salt stress|positive regulation of activation of JAK2 kinase activity|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|positive regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol esterification|negative regulation of endopeptidase activity|regulation of norepinephrine secretion|positive regulation of phosphatidylinositol 3-kinase signaling|artery smooth muscle contraction|response to muscle activity involved in regulation of muscle adaptation|negative regulation of angiogenesis|regulation of vasoconstriction|regulation of proteolysis|extracellular matrix organization|negative regulation of cell growth|peristalsis|positive regulation of cellular protein metabolic process|positive regulation of superoxide anion generation|positive regulation of NAD(P)H oxidase activity|negative regulation of tissue remodeling|low-density lipoprotein particle remodeling|catenin import into nucleus|regulation of renal sodium excretion|positive regulation of renal sodium excretion|positive regulation of multicellular organism growth|regulation of cell proliferation|vasodilation|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|cellular lipid metabolic process|cellular protein metabolic process|small molecule metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of organ growth|astrocyte activation|fibroblast proliferation|positive regulation of fibroblast proliferation|regulation of long-term neuronal synaptic plasticity|smooth muscle cell proliferation|cytokine secretion|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of NF-kappaB transcription factor activity|smooth muscle cell differentiation|negative regulation of neurotrophin TRK receptor signaling pathway|stress-activated MAPK cascade|regulation of calcium ion transport|cell growth involved in cardiac muscle cell development|positive regulation of protein tyrosine kinase activity|ERK1 and ERK2 cascade|uterine smooth muscle contraction|cellular response to mechanical stimulus|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of reactive oxygen species metabolic process|positive regulation of extrinsic apoptotic signaling pathway|",serine-type endopeptidase inhibitor activity|hormone activity|hormone activity|protein binding|growth factor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding|,10,1.9,3.29,10,-3.2,5.51,-3.5,6.8,0.0371,-9.7,0.5
ENSMUSG00000076744,TCRG-V7,"T cell receptor gamma, variable 7",None,None,None,8,1.4,1.31,10,-3.2,7.3,-3.2,6.79,0.0372,-8.6,-0.2
ENSMUSG00000022710,USP7,ubiquitin specific peptidase 7 (herpes virus-associated),nucleus|cytosol|PML body|,transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|multicellular organismal development|maintenance of DNA methylation|viral process|protein deubiquitination|protein deubiquitination|negative regulation of NF-kappaB transcription factor activity|regulation of sequence-specific DNA binding transcription factor activity|,p53 binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|ubiquitin-specific protease activity|protein binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|,6,-5.2,0.615,8,4.9,9.19,4.5,6.78,0.0373,-1.2,11
ENSMUSG00000029166,MAPRE3,"microtubule-associated protein, RP/EB family, member 3",cytoplasm|cytoplasm|microtubule|cytoplasmic microtubule|microtubule cytoskeleton|midbody|perinuclear region of cytoplasm|,"mitotic nuclear division|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription, DNA-templated|",protein binding|microtubule binding|,10,-6.7,9.84,10,1.4,0.931,-6.7,6.77,0.0374,-11.9,-0.5
ENSMUSG00000020608,SMC6,structural maintenance of chromosomes 6,"chromosome, telomeric region|intracellular|nucleus|nucleolus|PML body|Smc5-Smc6 complex|",telomere maintenance via recombination|double-strand break repair via homologous recombination|cellular senescence|,protein binding|ATP binding|,10,-3.2,3.6,10,-4.3,3.73,-3.4,6.77,0.0374,-8.5,-0.2
ENSMUSG00000040354,MARS,methionyl-tRNA synthetase,cytoplasm|mitochondrion|cytosol|membrane|extracellular vesicular exosome|,tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation|gene expression|,tRNA binding|methionine-tRNA ligase activity|ATP binding|,6,-3.9,2.06,7,-4.6,5.18,-4.2,6.76,0.0375,-9.5,-1.2
ENSMUSG00000063080,GM14501,predicted gene 14501,nucleosome|cellular_component|nucleus|chromosome|,biological_process|,molecular_function|DNA binding|,0,0,0,2,-3.9,6.91,-3.9,6.73,0.0377,-7,-1.7
ENSMUSG00000042485,MUSTN1,"musculoskeletal, embryonic nuclear protein 1",nucleus|,None,None,2,-2.5,2.1,3,-3.1,5.07,-2.9,6.73,0.0377,-6,-1.1
ENSMUSG00000072962,GM16401,predicted gene 16401,None,None,None,1,1.6,0.879,1,-5.7,7.52,-5.7,6.73,0.0377,-11,-1.8
ENSMUSG00000096571,1700012L04RIK,RIKEN cDNA 1700012L04 gene,nucleosome|nucleus|chromosome|,None,DNA binding|,0,0,0,2,-3.9,6.91,-3.9,6.73,0.0377,-7,-1.7
ENSMUSG00000042548,ASXL1,additional sex combs like transcriptional regulator 1,nuclear chromatin|PR-DUB complex|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|response to retinoic acid|negative regulation of peroxisome proliferator activated receptor signaling pathway|monoubiquitinated histone H2A deubiquitination|negative regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of retinoic acid receptor signaling pathway|negative regulation of retinoic acid receptor signaling pathway|bone development|",DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|metal ion binding|,0,0,0,1,5.8,6.89,5.8,6.7,0.0382,3.2,12
ENSMUSG00000050953,GJA1,"gap junction protein, alpha 1, 43kDa",Golgi membrane|mitochondrial outer membrane|lysosome|early endosome|multivesicular body|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|plasma membrane|integral component of plasma membrane|fascia adherens|gap junction|gap junction|connexon complex|intercalated disc|intercalated disc|Golgi-associated vesicle membrane|membrane raft|extracellular vesicular exosome|,chronic inflammatory response|positive regulation of glomerular filtration|endothelium development|transport|apoptotic process|muscle contraction|signal transduction|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|heart development|response to pH|vascular transport|cell communication by electrical coupling|positive regulation of cell communication by chemical coupling|ATP transport|gap junction assembly|ion transmembrane transport|response to fluid shear stress|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to peptide hormone|positive regulation of protein catabolic process|positive regulation of vasoconstriction|positive regulation of vasodilation|neuron projection morphogenesis|protein oligomerization|regulation of calcium ion transport|transmembrane transport|negative regulation of cardiac muscle cell proliferation|membrane organization|cellular response to mechanical stimulus|atrial cardiac muscle cell action potential|regulation of tight junction assembly|positive regulation of behavioral fear response|,signal transducer activity|gap junction channel activity|protein binding|ion transmembrane transporter activity|SH3 domain binding|PDZ domain binding|connexin binding|,9,-3.1,2.22,10,-3,4.78,-3.1,6.68,0.0384,-7.6,-0.1
ENSMUSG00000038860,GARNL3,GTPase activating Rap/RanGAP domain-like 3,None,positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,small GTPase regulator activity|GTPase activator activity|,10,-4.1,9.51,10,0,0,-4,6.67,0.0386,-7.7,-0.9
ENSMUSG00000032000,BIRC3,baculoviral IAP repeat containing 3,nucleus|cytoplasm|cytosol|protein complex|membrane raft|,toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|apoptotic process|cell surface receptor signaling pathway|spermatogenesis|protein ubiquitination|positive regulation of protein ubiquitination|regulation of toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|regulation of RIG-I signaling pathway|negative regulation of phosphorylation|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of innate immune response|regulation of inflammatory response|protein heterooligomerization|regulation of necroptotic process|negative regulation of necroptotic process|necroptotic process|regulation of nucleotide-binding oligomerization domain containing signaling pathway|regulation of cysteine-type endopeptidase activity|negative regulation of reactive oxygen species metabolic process|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,10,-3,1.59,10,-3.3,5.44,-3.2,6.67,0.0386,-8.1,-0.3
ENSMUSG00000061132,BLNK,B-cell linker,intracellular|cytosol|plasma membrane|,inflammatory response|humoral immune response|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of signal transduction|positive regulation of signal transduction|B cell differentiation|intracellular signal transduction|,transmembrane receptor protein tyrosine kinase adaptor activity|SH3/SH2 adaptor activity|SH3/SH2 adaptor activity|protein binding|,10,-4,2.97,10,-2,5,-3.2,6.66,0.0387,-8.9,0.6
ENSMUSG00000045328,CENPE,"centromere protein E, 312kDa","chromosome, centromeric region|kinetochore|condensed nuclear chromosome kinetochore|condensed chromosome, centromeric region|condensed chromosome outer kinetochore|nucleus|cytoplasm|spindle|cytosol|kinesin complex|microtubule|microtubule cytoskeleton|membrane|",mitotic metaphase|mitotic cell cycle|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|multicellular organismal development|blood coagulation|metabolic process|metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class II|positive regulation of protein kinase activity|kinetochore assembly|,microtubule motor activity|protein binding|ATP binding|microtubule binding|kinetochore binding|,7,4.3,6.95,9,-1.7,2.72,3.5,6.65,0.0388,-1.2,10
ENSMUSG00000034636,ZYG11B,"zyg-11 family member B, cell cycle regulator",None,None,None,0,0,0,1,5.8,6.82,5.8,6.64,0.0391,3,11
ENSMUSG00000016524,IL19,interleukin 19,extracellular region|extracellular space|,apoptotic process|immune response|signal transduction|interleukin-6 biosynthetic process|reactive oxygen species metabolic process|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,cytokine activity|,10,-3.4,8.03,10,-1.2,0.763,-3.2,6.63,0.0392,-6.2,-0.5
ENSMUSG00000090035,GALNT4,polypeptide N-acetylgalactosaminyltransferase 4,Golgi membrane|Golgi apparatus|integral component of membrane|perinuclear region of cytoplasm|extracellular vesicular exosome|,carbohydrate metabolic process|O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,9,-4.8,6.54,10,-1.5,2.94,-3.2,6.58,0.0399,-7.8,-0.5
ENSMUSG00000032068,1600029D21RIK,N/A,None,None,None,0,0,0,1,-5.6,6.74,-5.6,6.55,0.0404,-11,-2.6
ENSMUSG00000027427,POLR3F,"polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa",nucleoplasm|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase III complex|cytosol|,regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus|,RNA polymerase III activity|DNA binding|DNA-directed RNA polymerase activity|protein binding|,8,4.3,6.02,8,4.3,0.757,4.3,6.54,0.0405,1.8,10
ENSMUSG00000058019,CES5A,carboxylesterase 5A,extracellular region|,metabolic process|,carboxylic ester hydrolase activity|,10,-3.9,4.42,10,-3.2,2.48,-3.8,6.53,0.0407,-7.6,-0.3
ENSMUSG00000020745,PAFAH1B1,"platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)",astral microtubule|kinetochore|nuclear envelope|centrosome|centrosome|cytosol|cytosol|kinesin complex|microtubule associated complex|cell cortex|growth cone|cell leading edge|motile primary cilium|nuclear membrane|neuronal cell body|perinuclear region of cytoplasm|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|mitotic cell cycle|ameboidal cell migration|acrosome assembly|neuron migration|neuron migration|positive regulation of cytokine-mediated signaling pathway|microtubule-based process|mitotic nuclear division|nuclear migration|synaptic transmission|neuroblast proliferation|learning or memory|retrograde axon cargo transport|adult locomotory behavior|protein secretion|negative regulation of neuron projection development|lipid catabolic process|stem cell division|transmission of nerve impulse|corpus callosum morphogenesis|hippocampus development|layer formation in cerebral cortex|cerebral cortex neuron differentiation|cerebral cortex development|actin cytoskeleton organization|microtubule organizing center organization|regulation of Rho GTPase activity|osteoclast development|positive regulation of axon extension|positive regulation of mitotic cell cycle|negative regulation of JNK cascade|platelet activating factor metabolic process|vesicle transport along microtubule|brain morphogenesis|neuromuscular process controlling balance|nuclear envelope disassembly|establishment of centrosome localization|,protein binding|microtubule binding|heparin binding|dynactin binding|protein homodimerization activity|phospholipase binding|dynein binding|dynein intermediate chain binding|phosphoprotein binding|,8,6.1,9.64,8,-1.3,1.21,6,6.52,0.0409,-4,14
ENSMUSG00000037225,FGF2,fibroblast growth factor 2 (basic),extracellular region|extracellular space|nucleus|cytosol|,"activation of MAPKK activity|activation of MAPK activity|MAPK import into nucleus|branching involved in ureteric bud morphogenesis|organ induction|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|cell migration involved in sprouting angiogenesis|phosphatidylinositol biosynthetic process|C21-steroid hormone biosynthetic process|chemotaxis|signal transduction|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|nervous system development|positive regulation of cell proliferation|negative regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|organ morphogenesis|glial cell differentiation|negative regulation of fibroblast migration|positive regulation of phospholipase C activity|substantia nigra development|positive regulation of cerebellar granule cell precursor proliferation|extracellular matrix organization|hyaluronan catabolic process|negative regulation of cell growth|lung development|inositol phosphate biosynthetic process|Fc-epsilon receptor signaling pathway|wound healing|positive regulation of cell fate specification|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|positive regulation of osteoblast differentiation|regulation of angiogenesis|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of retinal cell programmed cell death|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|embryonic morphogenesis|response to axon injury|stem cell development|positive chemotaxis|release of sequestered calcium ion into cytosol|regulation of cell cycle|positive regulation of cell division|positive regulation of cardiac muscle cell proliferation|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|negative regulation of cell death|chondroblast differentiation|mammary gland epithelial cell differentiation|negative regulation of wound healing|positive regulation of ERK1 and ERK2 cascade|",fibroblast growth factor receptor binding|cytokine activity|protein binding|growth factor activity|heparin binding|fibroblast growth factor binding|ligand-dependent nuclear receptor transcription coactivator activity|chemoattractant activity|,10,-4.5,1.35,10,-3.2,5.6,-3.4,6.52,0.0409,-7.6,-0.4
ENSMUSG00000028156,EIF4E,eukaryotic translation initiation factor 4E,cytoplasmic mRNA processing body|cytoplasm|cytosol|mRNA cap binding complex|cytoplasmic stress granule|eukaryotic translation initiation factor 4F complex|RISC complex|chromatoid body|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|mRNA export from nucleus|translation|translational initiation|regulation of translation|insulin receptor signaling pathway|gene expression|viral process|RNA metabolic process|mRNA metabolic process|cytokine-mediated signaling pathway|lung development|cellular protein metabolic process|positive regulation of mitotic cell cycle|",RNA cap binding|translation initiation factor activity|translation initiation factor activity|protein binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding|,5,4.1,8.3,5,0,0,4,6.51,0.0412,1.7,9
ENSMUSG00000042308,SETD1A,SET domain containing 1A,nucleus|chromosome|nuclear speck|histone methyltransferase complex|Set1C/COMPASS complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K4 methylation|",nucleotide binding|RNA binding|protein binding|histone methyltransferase activity (H3-K4 specific)|,9,-5.9,4.08,10,-2.5,4.22,-3.1,6.51,0.0412,-8.5,-0.4
ENSMUSG00000029632,NDUFA4,"NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa",mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex IV|extracellular vesicular exosome|,"mitochondrial electron transport, NADH to ubiquinone|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|hydrogen ion transmembrane transport|",cytochrome-c oxidase activity|NADH dehydrogenase (ubiquinone) activity|protein complex binding|,9,-2.2,1.15,9,-3.6,5.92,-3.4,6.49,0.0414,-10,0.5
ENSMUSG00000002102,PSMC3,"proteasome (prosome, macropain) 26S subunit, ATPase, 3",proteasome complex|cytoplasmic mRNA processing body|nucleus|nucleoplasm|cytosol|membrane|proteasome accessory complex|perinuclear region of cytoplasm|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|blastocyst development|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of RNA biosynthetic process|",transcription coactivator activity|transcription corepressor activity|protein binding|ATP binding|ATPase activity|,8,-3.6,3.44,9,-3.3,3.36,-3.5,6.47,0.0417,-9.2,-0.3
ENSMUSG00000046643,OLFR218,olfactory receptor 218,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,10,3.8,8.17,10,0.7,0.0994,3.4,6.47,0.0417,0.5,8.1
ENSMUSG00000047466,8030462N17RIK,RIKEN cDNA 8030462N17 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,5.7,6.65,5.7,6.47,0.0417,3,11
ENSMUSG00000035960,APEX1,APEX nuclease (multifunctional DNA repair enzyme) 1,nucleus|nucleoplasm|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|ribosome|nuclear speck|perinuclear region of cytoplasm|,"DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|DNA repair|DNA repair|base-excision repair|base-excision repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|aging|negative regulation of smooth muscle cell migration|response to drug|regulation of mRNA stability|cell redox homeostasis|positive regulation of DNA repair|oxidation-reduction process|cellular response to hydrogen peroxide|cellular response to cAMP|cellular response to peptide hormone stimulus|DNA demethylation|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|RNA phosphodiester bond hydrolysis, endonucleolytic|positive regulation of G1/S transition of mitotic cell cycle|","DNA binding|damaged DNA binding|transcription coactivator activity|transcription corepressor activity|DNA-(apurinic or apyrimidinic site) lyase activity|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|endodeoxyribonuclease activity|RNA-DNA hybrid ribonuclease activity|phosphodiesterase I activity|uracil DNA N-glycosylase activity|protein binding|phosphoric diester hydrolase activity|double-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|3'-5' exonuclease activity|oxidoreductase activity|site-specific endodeoxyribonuclease activity, specific for altered base|chromatin DNA binding|protein complex binding|poly(A) RNA binding|metal ion binding|NF-kappaB binding|",10,1.1,0.728,10,-2.4,6.36,-2.3,6.42,0.0422,-5.9,0
ENSMUSG00000009670,TEX11,testis expressed 11,synaptonemal complex|central element|,resolution of meiotic recombination intermediates|meiotic gene conversion|male meiosis chromosome segregation|synaptonemal complex assembly|reciprocal meiotic recombination|male gonad development|fertilization|negative regulation of apoptotic process|chiasma assembly|,protein binding|,10,-3.3,4.98,10,-1.7,2.4,-2,6.41,0.0424,-5.3,-0.3
ENSMUSG00000037169,MYCN,v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog,chromatin|nucleus|,cartilage condensation|positive regulation of mesenchymal cell proliferation|regulation of transcription from RNA polymerase II promoter|positive regulation of cell death|lung development|embryonic digit morphogenesis|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|negative regulation of astrocyte differentiation|branching morphogenesis of an epithelial tube|negative regulation of reactive oxygen species metabolic process|,DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|protein dimerization activity|,10,-2.2,3.83,9,-3.1,2.98,-2.3,6.39,0.0428,-6.3,-0.6
ENSMUSG00000032796,LAMA1,"laminin, alpha 1",extracellular region|proteinaceous extracellular matrix|basement membrane|laminin-1 complex|laminin-1 complex|laminin-3 complex|extracellular space|cell-cell junction|extracellular matrix|,morphogenesis of an epithelial sheet|cell adhesion|cell surface receptor signaling pathway|axon guidance|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|establishment of epithelial cell apical/basal polarity|regulation of embryonic development|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|retinal blood vessel morphogenesis|,receptor binding|extracellular matrix structural constituent|protein binding|glycosphingolipid binding|,10,-1.2,2.55,10,-1.7,4.35,-1.5,6.38,0.0429,-7.5,-0.1
ENSMUSG00000027525,PHACTR3,phosphatase and actin regulator 3,nucleus|nuclear matrix|,negative regulation of catalytic activity|,actin binding|protein phosphatase inhibitor activity|,10,-6.8,8.22,10,-1.2,0.624,-5.3,6.37,0.0432,-11.9,-0.6
ENSMUSG00000068600,HEMT1,hematopoietic cell transcript 1,cellular_component|,biological_process|,molecular_function|,10,-4.3,4.48,10,3.9,9.22,3.7,6.36,0.0435,-5.1,10
ENSMUSG00000043162,PYURF,PIGY upstream reading frame,glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|mitochondrion|endoplasmic reticulum membrane|,GPI anchor biosynthetic process|positive regulation of metabolic process|,protein binding|,0,0,0,3,2.7,6.52,2.7,6.34,0.0438,1.1,6
ENSMUSG00000098753,PYURF,PIGY upstream reading frame,glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|mitochondrion|endoplasmic reticulum membrane|,GPI anchor biosynthetic process|positive regulation of metabolic process|,protein binding|,0,0,0,3,2.7,6.52,2.7,6.34,0.0438,1.1,6
ENSMUSG00000030682,CDIPT,CDP-diacylglycerol--inositol 3-phosphatidyltransferase,Golgi membrane|endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|,phospholipid metabolic process|phosphatidylinositol biosynthetic process|phosphatidylinositol biosynthetic process|small molecule metabolic process|CDP-diacylglycerol metabolic process|glycerophospholipid biosynthetic process|,CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|diacylglycerol binding|manganese ion binding|carbohydrate binding|alcohol binding|,4,-3.8,3.49,4,-2.6,3.51,-2.7,6.27,0.0451,-7.5,-0.8
ENSMUSG00000023906,CLDN6,claudin 6,plasma membrane|tight junction|integral component of membrane|,calcium-independent cell-cell adhesion|,structural molecule activity|identical protein binding|,1,5.5,6.41,0,0,0,5.5,6.23,0.0458,3,12
ENSMUSG00000021624,CD180,CD180 molecule,plasma membrane|integral component of membrane|,B cell proliferation involved in immune response|inflammatory response|positive regulation of lipopolysaccharide-mediated signaling pathway|innate immune response|cellular response to lipopolysaccharide|,None,10,-2.4,2.6,10,-5.8,4.93,-3.8,6.22,0.0459,-9.9,-0.3
ENSMUSG00000035048,ANAPC13,anaphase promoting complex subunit 13,anaphase-promoting complex|,mitotic nuclear division|protein K11-linked ubiquitination|,None,9,-5.5,6.96,9,-2.3,0.469,-4.4,6.22,0.0459,-10.8,-0.9
ENSMUSG00000079139,GM4204,nucleosome assembly protein 1-like 1 pseudogene,None,None,None,5,3.1,1.51,5,6.4,6.29,6.2,6.2,0.0463,-0.3,13
ENSMUSG00000078812,EIF5A,eukaryotic translation initiation factor 5A,nucleus|annulate lamellae|nuclear pore|cytoplasm|endoplasmic reticulum membrane|cytosol|membrane|extracellular vesicular exosome|,mRNA export from nucleus|translational frameshifting|protein export from nucleus|nucleocytoplasmic transport|apoptotic process|positive regulation of cell proliferation|peptidyl-lysine modification to peptidyl-hypusine|post-translational protein modification|cellular protein metabolic process|positive regulation of translational elongation|positive regulation of translational termination|,RNA binding|translation elongation factor activity|protein binding|U6 snRNA binding|ribosome binding|poly(A) RNA binding|protein N-terminus binding|,5,3.1,4.75,6,4.8,2.37,3.6,6.18,0.0468,-5.3,10
ENSMUSG00000029415,SDAD1,SDA1 domain containing 1,nucleolus|,ribosomal large subunit export from nucleus|protein transport|actin cytoskeleton organization|ribosomal large subunit biogenesis|,molecular_function|,8,5,1.57,8,-2.7,5.65,-2.7,6.17,0.0471,-9.5,1
ENSMUSG00000025154,ARHGAP19,Rho GTPase activating protein 19,nucleus|cytosol|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,1,5.5,6.36,0,0,0,5.5,6.17,0.0471,3,12
ENSMUSG00000041840,HAUS1,"HAUS augmin-like complex, subunit 1",spindle pole|cytoplasm|centrosome|microtubule|HAUS complex|,mitotic nuclear division|spindle assembly|centrosome organization|,molecular_function|protein binding|,9,-2.2,2.9,7,-1.6,3.71,-2.2,6.15,0.0474,-6.2,-0.1
ENSMUSG00000020492,SKA2,spindle and kinetochore associated complex subunit 2,condensed chromosome outer kinetochore|cytoplasm|cytosol|spindle microtubule|,mitotic cell cycle|chromosome segregation|mitotic nuclear division|regulation of microtubule polymerization or depolymerization|cell division|,protein binding|microtubule binding|,4,5.1,6.7,6,3,0.528,4.8,6.13,0.0477,-1.5,11
ENSMUSG00000032076,CADM1,cell adhesion molecule 1,plasma membrane|plasma membrane|cell-cell junction|synaptic vesicle|integral component of membrane|basolateral plasma membrane|axon|dendrite|extracellular vesicular exosome|,liver development|apoptotic process|homophilic cell adhesion|heterophilic cell-cell adhesion|spermatogenesis|synapse assembly|brain development|cell recognition|cell recognition|unidimensional cell growth|calcium-independent cell-cell adhesion|cell differentiation|cell junction assembly|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to natural killer cell mediated cytotoxicity|cell-cell junction organization|positive regulation of natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|positive regulation of cytokine secretion|detection of stimulus|detection of stimulus|bone development|,receptor binding|receptor binding|protein binding|protein C-terminus binding|PDZ domain binding|protein homodimerization activity|cell adhesion molecule binding|,10,-4.2,5.82,10,3.3,2.22,-2.4,6.07,0.0486,-8.4,1
ENSMUSG00000028484,PSIP1,PC4 and SFRS1 interacting protein 1,nucleus|nucleoplasm|nucleoplasm|nuclear heterochromatin|cytosol|nuclear periphery|transcriptionally active chromatin|,"mRNA 5'-splice site recognition|transcription, DNA-templated|regulation of transcription, DNA-templated|response to oxidative stress|response to heat|viral process|positive regulation of transcription from RNA polymerase II promoter|establishment of integrated proviral latency|",RNA polymerase II transcription coactivator activity|chromatin binding|protein binding|activating transcription factor binding|poly(A) RNA binding|supercoiled DNA binding|,10,2.6,4.79,10,4.4,1.7,2.7,6.06,0.0488,-2.9,8.6
ENSMUSG00000027198,EXT2,exostosin glycosyltransferase 2,Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|membrane|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|extracellular vesicular exosome|,"ossification|mesoderm formation|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan biosynthetic process|protein glycosylation|signal transduction|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|cell differentiation|glycosaminoglycan metabolic process|cellular polysaccharide biosynthetic process|small molecule metabolic process|","acetylglucosaminyltransferase activity|glucuronosyltransferase activity|transferase activity, transferring glycosyl groups|heparan sulfate N-acetylglucosaminyltransferase activity|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|",10,-4.9,5.64,10,-1.9,1.37,-2.7,6.04,0.0491,-7.8,-0.4
ENSMUSG00000060475,WTAP,Wilms tumor 1 associated protein,nucleus|nuclear speck|nuclear membrane|MIS complex|,"regulation of alternative mRNA splicing, via spliceosome|mRNA processing|cell cycle|RNA splicing|mRNA methylation|",None,10,3.7,0.319,10,3.4,5.9,3.5,5.99,0.0503,0.3,8.7
ENSMUSG00000014402,TSG101,tumor susceptibility 101,ESCRT I complex|nucleolus|cytoplasm|cytoplasm|early endosome|late endosome|multivesicular body|plasma membrane|endosome membrane|late endosome membrane|extracellular vesicular exosome|,"regulation of cell growth|cellular protein modification process|cell cycle arrest|negative regulation of cell proliferation|protein transport|viral process|endosomal transport|viral life cycle|virion assembly|viral protein processing|keratinocyte differentiation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|negative regulation of transcription, DNA-templated|viral budding|viral budding|cell division|membrane organization|intracellular transport of virus|",DNA binding|transcription corepressor activity|protein binding|ubiquitin protein ligase binding|protein homodimerization activity|ubiquitin binding|ubiquitin binding|calcium-dependent protein binding|,7,-3.3,4.87,9,-1.6,2.38,-2.7,5.99,0.0503,-5.7,-0.3
ENSMUSG00000038416,CDC16,cell division cycle 16,nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|spindle|cytosol|spindle microtubule|,mitotic cell cycle|mitotic nuclear division|regulation of mitosis|mitotic spindle assembly checkpoint|cell proliferation|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,protein binding|,4,-4.1,3.9,4,-2.1,2.86,-3.5,5.98,0.0505,-8.6,-0.9
ENSMUSG00000070473,CLDN3,claudin 3,integral component of plasma membrane|tight junction|integral component of membrane|extracellular vesicular exosome|,response to hypoxia|signal transduction|calcium-independent cell-cell adhesion|,transmembrane signaling receptor activity|structural molecule activity|identical protein binding|,10,-2.9,3.96,10,-1.8,2.63,-2.8,5.97,0.0506,-5.9,-0.1
ENSMUSG00000024793,TNFRSF25,"tumor necrosis factor receptor superfamily, member 25",extracellular region|cytosol|plasma membrane|integral component of plasma membrane|,apoptotic process|signal transduction|cell surface receptor signaling pathway|tumor necrosis factor-mediated signaling pathway|regulation of apoptotic process|apoptotic signaling pathway|,receptor activity|tumor necrosis factor-activated receptor activity|,9,-3.1,0.516,10,-3.2,5.64,-3.2,5.93,0.0513,-9,-0.1
ENSMUSG00000033871,PPARGC1B,"peroxisome proliferator-activated receptor gamma, coactivator 1 beta",nucleus|nucleoplasm|mitochondrion|mediator complex|,"ossification|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from mitochondrial promoter|actin filament organization|positive regulation of alkaline phosphatase activity|intracellular estrogen receptor signaling pathway|cellular response to reactive oxygen species|positive regulation of phosphorylation|cellular lipid metabolic process|small molecule metabolic process|positive regulation of osteoclast differentiation|positive regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|response to glucocorticoid|response to cAMP|bone trabecula formation|positive regulation of receptor activity|",nucleotide binding|RNA polymerase II transcription cofactor activity|RNA binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activator activity|AF-2 domain binding|,9,2.3,3.6,9,6.7,5.53,2.2,5.92,0.0515,0.5,12.6
ENSMUSG00000027079,CLP1,cleavage and polyadenylation factor I subunit 1,tRNA-intron endonuclease complex|nucleus|nucleoplasm|mRNA cleavage factor complex|,"mRNA splicing, via spliceosome|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA splicing, via endonucleolytic cleavage and ligation|cell death|RNA splicing|gene expression|phosphorylation|cerebellar cortex development|targeting of mRNA for destruction involved in RNA interference|mRNA 3'-end processing|siRNA loading onto RISC involved in RNA interference|",ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|polydeoxyribonucleotide kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|,8,1.9,2.2,6,4.6,5.28,2.5,5.89,0.052,0.2,9
ENSMUSG00000021207,AKR1C21,"aldo-keto reductase family 1, member C21",cytoplasm|cytosol|extracellular vesicular exosome|,lipid metabolic process|steroid biosynthetic process|G-protein coupled receptor signaling pathway|steroid metabolic process|oxidation-reduction process|,"C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|isocitrate dehydrogenase activity|mevaldate reductase activity|prostaglandin F receptor activity|gluconate dehydrogenase activity|steroid dehydrogenase activity|oxidoreductase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|epoxide dehydrogenase activity|5-exo-hydroxycamphor dehydrogenase activity|2-hydroxytetrahydrofuran dehydrogenase activity|phenanthrene 9,10-monooxygenase activity|acetoin dehydrogenase activity|carboxylic acid binding|bile acid binding|phenylcoumaran benzylic ether reductase activity|D-xylose:NADP reductase activity|L-arabinose:NADP reductase activity|D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity|steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|steroid dehydrogenase activity, acting on the CH-CH group of donors|(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity|3-hydroxymenthone dehydrogenase activity|very long-chain-3-hydroxyacyl-CoA dehydrogenase activity|dihydrotestosterone 17-beta-dehydrogenase activity|(R)-2-hydroxyisocaproate dehydrogenase activity|L-arabinose 1-dehydrogenase (NADP+) activity|L-xylulose reductase (NAD+) activity|androsterone dehydrogenase activity|androsterone dehydrogenase (B-specific) activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|3-ketoglucose-reductase activity|(R)-2-hydroxyglutarate dehydrogenase activity|D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity|",10,-1.6,1.25,10,-2.9,5.6,-2.6,5.89,0.052,-7.2,-0.1
ENSMUSG00000041343,ANKRD42,ankyrin repeat domain 42,nucleus|,positive regulation of NF-kappaB transcription factor activity|positive regulation of cytokine production involved in inflammatory response|,NF-kappaB binding|,0,0,0,1,5.4,6.06,5.4,5.88,0.0522,2.5,11
ENSMUSG00000031754,NUDT21,nudix (nucleoside diphosphate linked moiety X)-type motif 21,nucleus|nucleoplasm|centrosome|mRNA cleavage factor complex|paraspeckles|,"mRNA splicing, via spliceosome|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA processing|RNA splicing|gene expression|mRNA 3'-end processing|protein tetramerization|",RNA binding|mRNA binding|protein binding|hydrolase activity|AU-rich element binding|protein homodimerization activity|histone deacetylase binding|poly(A) RNA binding|,8,0,0,10,-3.6,6.65,-3.6,5.87,0.0525,-8.4,-0.3
ENSMUSG00000020230,PRMT2,protein arginine methyltransferase 2,nucleus|nucleolus|cytoplasm|cytosol|Rb-E2F complex|,"protein methylation|signal transduction|histone methylation|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|negative regulation of NF-kappaB transcription factor activity|histone arginine methylation|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|developmental cell growth|regulation of androgen receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|",transcription coactivator activity|signal transducer activity|protein binding|histone-arginine N-methyltransferase activity|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|estrogen receptor binding|estrogen receptor binding|progesterone receptor binding|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|protein homodimerization activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|thyroid hormone receptor binding|androgen receptor binding|,10,-0.9,1.4,10,-1.6,5.18,-1.3,5.87,0.0525,-4.2,-0.1
ENSMUSG00000025269,APEX2,APEX nuclease (apurinic/apyrimidinic endonuclease) 2,nucleus|mitochondrial inner membrane|,"DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|base-excision repair|DNA recombination|cell cycle|",DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|zinc ion binding|double-stranded DNA 3'-5' exodeoxyribonuclease activity|,10,-2.7,6.2,10,-1.1,0.656,-2.4,5.86,0.0527,-6.4,-0.2
ENSMUSG00000026113,INPP4A,"inositol polyphosphate-4-phosphatase, type I, 107kDa",cytosol|,phospholipid metabolic process|phosphatidylinositol biosynthetic process|signal transduction|dephosphorylation|phosphatidylinositol-3-phosphate biosynthetic process|inositol phosphate metabolic process|small molecule metabolic process|,"phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|",10,-1.3,2.47,10,-4.4,5.9,-3.4,5.84,0.0531,-8.7,-0.2
ENSMUSG00000030172,ERC1,ELKS/RAB6-interacting/CAST family member 1,Golgi membrane|cytoplasm|IkappaB kinase complex|presynaptic membrane|,"regulation of transcription, DNA-templated|I-kappaB phosphorylation|multicellular organismal development|protein transport|retrograde transport, endosome to Golgi|positive regulation of NF-kappaB transcription factor activity|",protein binding|Rab GTPase binding|leucine zipper domain binding|,10,-1.9,1.17,10,-1.7,4.94,-1.8,5.83,0.0533,-5.4,0.1
ENSMUSG00000070544,TOP1,topoisomerase (DNA) I,nuclear chromosome|cytoplasmic mRNA processing body|nucleus|nucleoplasm|nucleolus|replication fork protection complex|perikaryon|,ATP catabolic process|DNA replication|DNA topological change|DNA topological change|chromatin remodeling|chromosome segregation|programmed cell death|viral process|phosphorylation|embryonic cleavage|response to drug|,DNA binding|chromatin binding|DNA topoisomerase type I activity|DNA topoisomerase type I activity|DNA topoisomerase type II (ATP-hydrolyzing) activity|protein binding|poly(A) RNA binding|,8,-4.3,6.94,9,-1.1,1.49,-4,5.83,0.0533,-11,0
ENSMUSG00000040627,AICDA,activation-induced cytidine deaminase,exosome (RNase complex)|nucleus|cytoplasm|,mRNA processing|cytidine deamination|somatic diversification of immunoglobulins|somatic hypermutation of immunoglobulin genes|B cell differentiation|isotype switching|cellular response to lipopolysaccharide|DNA demethylation|negative regulation of methylation-dependent chromatin silencing|,cytidine deaminase activity|cytidine deaminase activity|protein binding|zinc ion binding|,10,-1.9,4.09,10,-4.3,3.03,-1.7,5.8,0.0541,-8.3,-0.1
ENSMUSG00000025504,EPS8L2,EPS8-like 2,cytoplasm|plasma membrane|ruffle membrane|protein complex|extracellular vesicular exosome|,Rho protein signal transduction|positive regulation of Rho GTPase activity|positive regulation of Rac GTPase activity|regulation of Rho protein signal transduction|positive regulation of ruffle assembly|,actin binding|Rho guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|,1,5.6,6.62,1,-2.7,1.6,5.5,5.79,0.0542,-1,12
ENSMUSG00000060969,IRX1,iroquois homeobox 1,nucleus|,"regulation of transcription, DNA-templated|specification of loop of Henle identity|proximal/distal pattern formation involved in metanephric nephron development|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-2.5,0.972,1,-5.3,5.48,-5.3,5.79,0.0542,-10,-1.9
ENSMUSG00000066233,TMEM42,transmembrane protein 42,integral component of membrane|,None,None,0,0,0,1,5.4,5.96,5.4,5.78,0.0544,2.4,11
ENSMUSG00000006335,TFPT,TCF3 (E2A) fusion partner (in childhood Leukemia),nucleus|nucleus|nucleolus|cytoplasm|actin filament|Ino80 complex|,"DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of apoptotic process|apoptotic signaling pathway|",DNA binding|protein binding|protein kinase binding|protein heterodimerization activity|,10,-4.1,6.07,10,-0.4,0.264,-4.1,5.77,0.0546,-13,1
ENSMUSG00000068349,GML,glycosylphosphatidylinositol anchored molecule like,plasma membrane|extrinsic component of membrane|anchored component of membrane|,"apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation|",None,10,2.3,6.15,8,-2.4,1.63,2.4,5.75,0.0549,-1.8,6.5
ENSMUSG00000005779,PSMB4,"proteasome (prosome, macropain) subunit, beta type, 4",proteasome complex|nucleus|nucleus|nucleoplasm|cytosol|proteasome core complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",lipopolysaccharide binding|threonine-type endopeptidase activity|,5,-5.2,3.21,4,4.3,5.53,3.3,5.75,0.0549,-6.6,9
ENSMUSG00000034906,NCAPH,"non-SMC condensin I complex, subunit H",condensin complex|nucleus|cytoplasm|cytosol|microtubule cytoskeleton|membrane|,mitotic cell cycle|mitotic chromosome condensation|,protein binding|,8,-4.1,4.12,8,-2.6,2.15,-3.2,5.74,0.0552,-8.7,6
ENSMUSG00000017146,BRCA1,"breast cancer 1, early onset",ubiquitin ligase complex|ruffle|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|focal adhesion|gamma-tubulin ring complex|ribonucleoprotein complex|BRCA1-BARD1 complex|filamentous actin|protein complex|BRCA1-A complex|,"double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|DNA repair|postreplication repair|double-strand break repair|double-strand break repair|regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|fatty acid biosynthetic process|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|chromosome segregation|intrinsic apoptotic signaling pathway in response to DNA damage|response to ionizing radiation|protein ubiquitination|androgen receptor signaling pathway|positive regulation of protein ubiquitination|G2 DNA damage checkpoint|substrate adhesion-dependent cell spreading|positive regulation of histone acetylation|regulation of cell proliferation|regulation of apoptotic process|response to estrogen|negative regulation of fatty acid biosynthetic process|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of centriole replication|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|protein autoubiquitination|positive regulation of histone H4-K20 methylation|positive regulation of cell cycle arrest|cellular response to indole-3-methanol|protein K6-linked ubiquitination|regulation of cell motility|positive regulation of histone H3-K9 acetylation|positive regulation of histone H4-K16 acetylation|",DNA binding|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|tubulin binding|ligase activity|enzyme binding|ubiquitin protein ligase binding|transcription regulatory region DNA binding|androgen receptor binding|,8,-3.4,7.17,10,-1,0.436,-3.2,5.74,0.0552,-8.9,0
ENSMUSG00000005699,PARD6A,par-6 family cell polarity regulator alpha,ruffle|nucleus|cytosol|plasma membrane|tight junction|cell cortex|protein complex|apical part of cell|,cell cycle|transforming growth factor beta receptor signaling pathway|viral process|cell junction assembly|cell-cell junction organization|cell-cell junction maintenance|cell division|tight junction assembly|,protein kinase C binding|protein binding|transcription factor binding|Rho GTPase binding|GTP-dependent protein binding|,10,0.8,0.425,10,-4.7,6.53,-4.6,5.74,0.0552,-10.3,-0.3
ENSMUSG00000052429,PRMT1,protein arginine methyltransferase 1,nucleus|nucleoplasm|cytoplasm|cytosol|,"regulation of transcription, DNA-templated|protein methylation|cell surface receptor signaling pathway|histone methylation|peptidyl-arginine methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|neuron projection development|histone H4-R3 methylation|negative regulation of megakaryocyte differentiation|",protein binding|methyltransferase activity|N-methyltransferase activity|N-methyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|identical protein binding|histone methyltransferase activity (H4-R3 specific)|poly(A) RNA binding|,8,4.5,1.29,7,6.8,5.74,6.6,5.72,0.0555,-2.1,14
ENSMUSG00000021018,POLR2H,polymerase (RNA) II (DNA directed) polypeptide H,"nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|RNA splicing|gene expression|viral process|positive regulation of type I interferon production|innate immune response|positive regulation of viral transcription|",RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|DNA binding|,6,2.6,3.64,9,-1.9,4.59,-2.3,5.71,0.0558,-6.6,4.5
ENSMUSG00000094601,GM5926,predicted gene 5926,cellular_component|,biological_process|,molecular_function|,3,3.6,5.24,2,-3.5,2.46,3.4,5.71,0.0558,-3.6,8
ENSMUSG00000095770,GM21637,"predicted gene, 21637",None,None,None,3,3.6,5.24,2,-3.5,2.46,3.4,5.71,0.0558,-3.6,8
ENSMUSG00000026039,SGOL2,shugoshin-like 2 (S. pombe),"chromosome, centromeric region|condensed chromosome kinetochore|nucleus|cytosol|mitotic cohesin complex|","mitotic cell cycle|meiotic sister chromatid cohesion, centromeric|",protein binding|,10,1.9,1.57,10,-2.6,5.3,-2.4,5.71,0.0558,-6.8,2
ENSMUSG00000031137,FGF13,fibroblast growth factor 13,extracellular region|nucleus|nucleolus|cytoplasm|cytoplasm|microtubule|plasma membrane|intercalated disc|filopodium|axon|dendrite|growth cone|neuron projection|,MAPK cascade|neuron migration|negative regulation of microtubule depolymerization|signal transduction|cell-cell signaling|nervous system development|learning|memory|hippocampus development|cerebral cortex cell migration|establishment of neuroblast polarity|positive regulation of protein kinase activity|microtubule polymerization|negative regulation of collateral sprouting|protein localization to plasma membrane|,protein binding|microtubule binding|growth factor activity|sodium channel regulator activity|protein kinase activator activity|ion channel binding|beta-tubulin binding|,10,-2.7,2.24,10,-3.6,3.97,-2.8,5.7,0.056,-7.1,0.1
ENSMUSG00000031516,DCTN6,dynactin 6,condensed chromosome kinetochore|centrosome|cytosol|dynactin complex|,antigen processing and presentation of exogenous peptide antigen via MHC class II|,dynein binding|,6,-4.5,4.12,5,-2.5,3.01,-2.7,5.7,0.056,-8.9,-0.2
ENSMUSG00000026245,FARSB,"phenylalanyl-tRNA synthetase, beta subunit",cytoplasm|cytosol|membrane|,translation|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|gene expression|,magnesium ion binding|RNA binding|phenylalanine-tRNA ligase activity|ATP binding|,7,-4,6.28,6,-1.5,0.646,-3,5.7,0.056,-8,-0.4
ENSMUSG00000015880,NCAPG,"non-SMC condensin I complex, subunit G",condensin complex|nucleus|cytoplasm|centrosome|cytosol|actin cytoskeleton|membrane|,mitotic cell cycle|mitotic chromosome condensation|mitotic chromosome condensation|,protein binding|,7,-3.2,2.02,7,6.4,4.18,-2.6,5.69,0.0562,-8.7,11
ENSMUSG00000038379,TTK,TTK protein kinase,spindle|membrane|,spindle organization|mitotic spindle organization|mitotic spindle assembly checkpoint|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|chromosome separation|,protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|,8,-3.2,4.48,7,-1.8,1.9,-3,5.67,0.0566,-8.8,0.1
ENSMUSG00000001674,DDX18,DEAD (Asp-Glu-Ala-Asp) box polypeptide 18,nucleolus|membrane|,ATP catabolic process|ATP catabolic process|,ATP-dependent RNA helicase activity|protein binding|ATP binding|poly(A) RNA binding|,4,-4.7,2.95,1,-3.6,3.23,-4.5,5.66,0.0567,-10,2.9
ENSMUSG00000060981,HIST1H4H,"histone cluster 1, H4h",None,None,None,6,0.9,1.1,7,-2.9,5.23,-2.9,5.65,0.057,-7.9,0.1
ENSMUSG00000037474,DTL,denticleless E3 ubiquitin protein ligase homolog (Drosophila),nucleus|chromosome|nucleolus|cytoplasm|centrosome|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|nuclear membrane|intracellular membrane-bounded organelle|,protein polyubiquitination|protein polyubiquitination|DNA replication|ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|translesion synthesis|G2 DNA damage checkpoint|regulation of cell cycle|,ubiquitin-protein transferase activity|protein binding|,7,6.6,5.23,6,2.5,1.75,-3.1,5.64,0.0573,-8,11.1
ENSMUSG00000017491,RARB,"retinoic acid receptor, beta",nucleus|nucleoplasm|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|growth plate cartilage development|transcription initiation from RNA polymerase II promoter|signal transduction|negative regulation of cell proliferation|gene expression|striatum development|regulation of myelination|negative regulation of chondrocyte differentiation|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|steroid hormone mediated signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|embryonic eye morphogenesis|retinoic acid receptor signaling pathway|embryonic digestive tract development|ventricular cardiac muscle cell differentiation|negative regulation of cartilage development|,DNA binding|steroid hormone receptor activity|retinoic acid receptor activity|protein binding|drug binding|zinc ion binding|protein complex binding|sequence-specific DNA binding|retinoid X receptor binding|,10,2.4,3.81,10,1.8,2.32,2,5.62,0.0577,-1.9,5.9
ENSMUSG00000032411,TFDP2,transcription factor Dp-2 (E2F dimerization partner 2),nucleoplasm|transcription factor complex|,"mitotic cell cycle|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|heart development|gene expression|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding|protein domain specific binding|,10,-1.8,4.77,10,-1.9,1.12,-1.9,5.62,0.0577,-9,3.1
ENSMUSG00000037224,ZFYVE28,"zinc finger, FYVE domain containing 28",cytosol|early endosome membrane|,negative regulation of epidermal growth factor-activated receptor activity|negative regulation of epidermal growth factor receptor signaling pathway|,protein binding|phosphatidylinositol-3-phosphate binding|metal ion binding|,0,0,0,1,5.3,5.8,5.3,5.62,0.0577,2.1,10
ENSMUSG00000008398,ELK3,"ELK3, ETS-domain protein (SRF accessory protein 2)",nucleus|nucleus|mitochondrion|intracellular membrane-bounded organelle|,"angiogenesis|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|signal transduction|cell differentiation|wound healing|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|purine-rich negative regulatory element binding|,10,-3.2,4.38,10,-4.2,1.75,-3.4,5.61,0.058,-9.4,-0.1
ENSMUSG00000036446,LUM,lumican,extracellular region|extracellular region|proteinaceous extracellular matrix|fibrillar collagen trimer|extracellular space|Golgi lumen|extracellular matrix|extracellular matrix|lysosomal lumen|extracellular vesicular exosome|,carbohydrate metabolic process|visual perception|response to organic cyclic compound|keratan sulfate biosynthetic process|extracellular matrix organization|collagen fibril organization|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate catabolic process|small molecule metabolic process|positive regulation of transcription from RNA polymerase II promoter|cartilage development|response to growth factor|,extracellular matrix structural constituent|collagen binding|,10,1.4,2.17,10,-3.7,7.17,-3.2,5.61,0.058,-8.6,1.7
ENSMUSG00000025410,DCTN2,dynactin 2 (p50),kinetochore|cytoplasm|centrosome|cytosol|dynactin complex|microtubule|membrane|dynein complex|growth cone|vesicle|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic spindle organization|mitotic nuclear division|metabolic process|cell proliferation|antigen processing and presentation of exogenous peptide antigen via MHC class II|,motor activity|protein binding|spectrin binding|,10,-4.1,3.82,9,-2.4,3.22,-3.9,5.6,0.0581,-7.8,0.1
ENSMUSG00000041567,SERPINA12,"serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12",extracellular space|,negative regulation of endopeptidase activity|regulation of proteolysis|,serine-type endopeptidase inhibitor activity|,10,1.9,3.15,10,2.5,2.95,2.3,5.6,0.0581,-0.2,5.8
ENSMUSG00000056602,FRY,furry homolog (Drosophila),spindle pole|cytoplasm|microtubule organizing center|,None,None,10,2.6,6.07,10,0.6,0.498,2.5,5.59,0.0584,-3.7,6.7
ENSMUSG00000037573,TOB1,"transducer of ERBB2, 1",nucleus|cytoplasm|CCR4-NOT complex|,"negative regulation of cell proliferation|positive regulation of signal transduction|negative regulation of translation|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|",SH3/SH2 adaptor activity|protein binding|receptor tyrosine kinase binding|,10,-4.4,2.47,10,-4,3.44,-4.3,5.59,0.0584,-8.6,-0.2
ENSMUSG00000070691,RUNX3,runt-related transcription factor 3,nuclear chromatin|nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|chondrocyte differentiation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein phosphorylation|axon guidance|hair follicle morphogenesis|interferon-gamma production|negative regulation of cell cycle|cell maturation|peripheral nervous system neuron development|negative regulation of epithelial cell proliferation|positive regulation of extrinsic apoptotic signaling pathway|",RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|ATP binding|,10,-2.1,0.999,10,-3,4.98,-2.8,5.57,0.0589,-7.9,1.2
ENSMUSG00000036893,EHMT1,euchromatic histone-lysine N-methyltransferase 1,nucleus|nucleus|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|,"negative regulation of transcription from RNA polymerase II promoter|DNA methylation|embryo development|chromatin modification|histone methylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|negative regulation of transcription, DNA-templated|histone H3-K9 methylation|histone H3-K27 methylation|",p53 binding|protein binding|methyltransferase activity|zinc ion binding|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|,9,-1.7,1.92,10,-3.3,4.72,-2.5,5.57,0.0589,-7.8,0.3
ENSMUSG00000023932,CDC5L,cell division cycle 5-like,Prp19 complex|nucleus|nucleolus|cytoplasm|membrane|nuclear speck|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|",DNA binding|chromatin binding|protein binding|poly(A) RNA binding|WD40-repeat domain binding|,8,-2.1,4.3,8,-2.1,1.55,-2.1,5.57,0.0589,-7.3,0.4
ENSMUSG00000038738,SHANK1,SH3 and multiple ankyrin repeat domains 1,intracellular|cytoplasm|plasma membrane|ionotropic glutamate receptor complex|membrane|N-methyl-D-aspartate selective glutamate receptor complex|cell junction|dendrite|neuron projection|dendritic spine|postsynaptic membrane|postsynaptic membrane|excitatory synapse|neuronal postsynaptic density|,protein complex assembly|cytoskeletal anchoring at plasma membrane|long-term memory|associative learning|adult behavior|negative regulation of actin filament bundle assembly|social behavior|protein localization to synapse|olfactory behavior|habituation|neuromuscular process controlling balance|determination of affect|righting reflex|synapse maturation|dendritic spine morphogenesis|positive regulation of dendritic spine development|vocalization behavior|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|positive regulation of excitatory postsynaptic membrane potential|,protein binding|protein C-terminus binding|SH3 domain binding|GKAP/Homer scaffold activity|somatostatin receptor binding|protein complex binding|ionotropic glutamate receptor binding|identical protein binding|ankyrin repeat binding|scaffold protein binding|,10,-1.9,1.8,10,-2.3,4.16,-2,5.56,0.0591,-5.8,1.6
ENSMUSG00000029387,GTF2H3,"general transcription factor IIH, polypeptide 3, 34kDa",core TFIIH complex|nucleoplasm|holo TFIIH complex|,"nucleotide-excision repair, DNA damage removal|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|translation|protein phosphorylation|gene expression|viral process|positive regulation of viral transcription|","damaged DNA binding|sequence-specific DNA binding transcription factor activity|protein kinase activity|DNA-dependent ATPase activity|translation factor activity, nucleic acid binding|RNA polymerase II carboxy-terminal domain kinase activity|metal ion binding|protein N-terminus binding|",9,-5.2,6.76,10,0.2,0.027,-5,5.55,0.0594,-10.6,-0.9
ENSMUSG00000023110,PRMT5,protein arginine methyltransferase 5,nucleus|nucleus|cytoplasm|cytosol|cytosol|methylosome|,"negative regulation of transcription from RNA polymerase II promoter|spliceosomal snRNP assembly|spliceosomal snRNP assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of mitosis|cell proliferation|gene expression|RNA metabolic process|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|circadian regulation of gene expression|ncRNA metabolic process|peptidyl-arginine N-methylation|endothelial cell activation|histone H4-R3 methylation|histone H4-R3 methylation|",core promoter sequence-specific DNA binding|chromatin binding|transcription corepressor activity|protein binding|methyltransferase activity|histone-arginine N-methyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein complex binding|,8,-2.6,3.19,7,-1.8,2.94,-2.2,5.54,0.0596,-6.1,0.4
ENSMUSG00000061864,GALNTL6,polypeptide N-acetylgalactosaminyltransferase-like 6,Golgi membrane|integral component of membrane|,protein glycosylation|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,-3.7,5.62,10,-1.3,1.29,-2.7,5.54,0.0596,-6.5,-0.2
ENSMUSG00000024454,HDAC3,histone deacetylase 3,histone deacetylase complex|nucleus|nucleus|nucleoplasm|cytoplasm|spindle microtubule|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|protein deacetylation|Notch signaling pathway|regulation of mitotic cell cycle|chromatin modification|circadian regulation of gene expression|regulation of multicellular organism growth|negative regulation of apoptotic process|cellular lipid metabolic process|small molecule metabolic process|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of JNK cascade|neurotrophin TRK receptor signaling pathway|spindle assembly|histone H3 deacetylation|histone H4 deacetylation|",chromatin binding|transcription corepressor activity|transcription corepressor activity|histone deacetylase activity|histone deacetylase activity|protein binding|transcription factor binding|transcription factor binding|enzyme binding|cyclin binding|chromatin DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD-dependent histone deacetylase activity (H3-K18 specific)|,9,2.8,3.86,9,-2.1,5.96,-2.2,5.54,0.0596,-7.1,4.8
ENSMUSG00000046240,HEPACAM,hepatic and glial cell adhesion molecule,cytoplasm|cell-cell junction|integral component of membrane|axon|,cell cycle arrest|cell adhesion|cellular protein localization|regulation of growth|,None,10,0,0,10,-3.5,7.09,-3.2,5.53,0.0598,-10.5,0.7
ENSMUSG00000037533,RAPGEF6,Rap guanine nucleotide exchange factor (GEF) 6,cytoplasm|plasma membrane|,Ras protein signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,guanyl-nucleotide exchange factor activity|protein binding|Ras GTPase binding|GTP-dependent protein binding|,1,3.2,3.42,1,-5.5,6.29,-5.5,5.52,0.0601,-11,4.9
ENSMUSG00000041133,SMC1A,structural maintenance of chromosomes 1A,"chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|cohesin core heterodimer|meiotic cohesin complex|","mitotic sister chromatid segregation|mitotic cell cycle|mRNA splicing, via spliceosome|DNA repair|mitotic spindle organization|sister chromatid cohesion|mitotic sister chromatid cohesion|mitotic cell cycle checkpoint|meiotic nuclear division|RNA splicing|response to radiation|gene expression|stem cell maintenance|negative regulation of DNA endoreduplication|signal transduction in response to DNA damage|",chromatin binding|microtubule motor activity|protein binding|ATP binding|mediator complex binding|poly(A) RNA binding|protein heterodimerization activity|,3,-3.9,5.29,2,-2.3,0.899,-3.7,5.51,0.0605,-8,-1.1
ENSMUSG00000029363,RFC5,"replication factor C (activator 1) 5, 36.5kDa",nucleoplasm|DNA replication factor C complex|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|",DNA binding|protein binding|ATP binding|nucleoside-triphosphatase activity|enzyme binding|,8,-3.8,5.8,10,-2.3,0.459,-3.7,5.49,0.0609,-7.5,-0.4
ENSMUSG00000021094,DHRS7,dehydrogenase/reductase (SDR family) member 7,membrane|,oxidation-reduction process|,oxidoreductase activity|,10,-1.9,4.08,10,-3.3,1.76,-3.5,5.48,0.0612,-7.8,0
ENSMUSG00000024066,XDH,xanthine dehydrogenase,extracellular space|peroxisome|cytosol|,negative regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|purine nucleobase metabolic process|purine nucleotide catabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|lactation|xanthine catabolic process|negative regulation of gene expression|small molecule metabolic process|negative regulation of endothelial cell differentiation|negative regulation of protein kinase B signaling|nucleobase-containing small molecule metabolic process|oxidation-reduction process|positive regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of reactive oxygen species metabolic process|negative regulation of vasculogenesis|,"xanthine dehydrogenase activity|xanthine oxidase activity|xanthine oxidase activity|iron ion binding|UDP-N-acetylmuramate dehydrogenase activity|electron carrier activity|protein homodimerization activity|molybdopterin cofactor binding|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|",10,-3.5,4.59,10,-1.6,2,-3.3,5.48,0.0612,-8,0
ENSMUSG00000007029,VARS,valyl-tRNA synthetase,mitochondrion|cytosol|,tRNA aminoacylation for protein translation|valyl-tRNA aminoacylation|regulation of translational fidelity|gene expression|,aminoacyl-tRNA editing activity|valine-tRNA ligase activity|ATP binding|,6,-4.6,6.6,6,-1.5,0.921,-4.3,5.47,0.0613,-9.8,-0.3
ENSMUSG00000024537,PSMG2,"proteasome (prosome, macropain) assembly chaperone 2",nucleus|nucleus|,mitotic spindle assembly checkpoint|negative regulation of apoptotic process|proteasome assembly|,protein binding|,9,-4.5,7.06,8,3.1,2.68,-4.2,5.44,0.0623,-9.8,2.2
ENSMUSG00000031723,TXNL4B,thioredoxin-like 4B,spliceosomal complex|,mRNA processing|mitotic nuclear division|RNA splicing|,None,10,2.2,1.19,10,-2.3,4.98,-2.2,5.43,0.0625,-8.9,1.8
ENSMUSG00000087260,LAMTOR5,"late endosomal/lysosomal adaptor, MAPK and MTOR activator 5",lysosome|cytosol|Ragulator complex|,regulation of cell size|response to virus|viral genome replication|positive regulation of TOR signaling|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of GTPase activity|protein localization to lysosome|cellular response to amino acid stimulus|,guanyl-nucleotide exchange factor activity|protein binding|protein complex scaffold|,9,-4.1,5.52,9,-1.4,1.98,-2.8,5.43,0.0625,-8,0.1
ENSMUSG00000013089,ETV5,ets variant 5,nucleus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|neuromuscular synaptic transmission|locomotory behavior|cell differentiation|cellular response to oxidative stress|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|male germ-line stem cell asymmetric division|regulation of synapse organization|positive regulation of glial cell proliferation|regulation of branching involved in mammary gland duct morphogenesis|skeletal muscle acetylcholine-gated channel clustering|,RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|,10,-5.8,4.44,10,-2.6,4.42,-3.1,5.43,0.0625,-9.3,-0.1
ENSMUSG00000022010,TSC22D1,"TSC22 domain family, member 1",nucleus|cytoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of apoptotic process|negative regulation of apoptotic process|",sequence-specific DNA binding transcription factor activity|protein binding|,9,-5.7,1.66,10,-2.3,5.85,-2.3,5.42,0.0627,-7.8,1.9
ENSMUSG00000022702,HIRA,histone cell cycle regulator,nuclear chromatin|nucleus|nucleoplasm|PML body|protein complex|,"osteoblast differentiation|DNA replication-independent nucleosome assembly|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|gastrulation|anatomical structure morphogenesis|chromatin modification|muscle cell differentiation|",chromatin binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|,10,-1.7,1.1,10,-1.8,4.58,-1.7,5.42,0.0627,-5.6,0.2
ENSMUSG00000039842,MCPH1,microcephalin 1,nucleoplasm|cytoplasm|microtubule organizing center|,mitotic cell cycle|cerebral cortex development|,protein binding|identical protein binding|,9,2.1,2.49,10,-2.8,6.31,-1.7,5.41,0.0629,-5.6,1.7
ENSMUSG00000031546,GINS4,GINS complex subunit 4 (Sld5 homolog),nucleoplasm|cytoplasm|,mitotic cell cycle|DNA strand elongation involved in DNA replication|,protein binding|,5,4.6,3.22,8,-2.7,6.81,-2.5,5.4,0.0631,-8,6.9
ENSMUSG00000011114,TBRG1,transforming growth factor beta regulator 1,nucleus|intracellular membrane-bounded organelle|,DNA replication|cell cycle arrest|negative regulation of cell proliferation|nucleolus to nucleoplasm transport|protein stabilization|,protein binding|,10,-6.9,5.65,10,-0.7,0.849,-5.1,5.4,0.0631,-12.3,-0.1
ENSMUSG00000028443,NUDT2,nudix (nucleoside diphosphate linked moiety X)-type motif 2,mitochondrion|,nucleobase-containing compound metabolic process|apoptotic process|,bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|GTP binding|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|,10,-1.5,3.54,10,-1.2,2.15,-1.5,5.38,0.0634,-5.7,1.1
ENSMUSG00000020634,UBXN2A,UBX domain protein 2A,endoplasmic reticulum|cis-Golgi network|cytosol|,regulation of gene expression|regulation of protein ubiquitination|regulation of protein catabolic process|,acetylcholine receptor binding|,2,-4.8,5.43,2,-1.9,1.08,-4.6,5.37,0.0636,-9,-1.3
ENSMUSG00000029994,ANXA4,annexin A4,nucleus|cytoplasm|cytoplasm|plasma membrane|cell surface|vesicle membrane|nuclear membrane|perinuclear region of cytoplasm|extracellular vesicular exosome|,regulation of transcription from RNA polymerase II promoter|signal transduction|epithelial cell differentiation|negative regulation of NF-kappaB transcription factor activity|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of interleukin-8 secretion|,phospholipase inhibitor activity|calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent phospholipid binding|identical protein binding|calcium-dependent protein binding|NF-kappaB binding|,10,-2.9,3.29,10,-1.6,2.93,-2.5,5.36,0.0639,-6.9,0.1
ENSMUSG00000032435,DYNC1LI1,"dynein, cytoplasmic 1, light intermediate chain 1",kinetochore|condensed chromosome kinetochore|spindle pole|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|plasma membrane|membrane|,transport|microtubule-based movement|mitotic nuclear division|metabolic process|viral process|positive regulation of mitotic cell cycle spindle assembly checkpoint|,microtubule motor activity|ATP binding|poly(A) RNA binding|,8,-0.1,0.0118,10,6.6,8.38,6.5,5.35,0.0641,0.3,14
ENSMUSG00000001739,CLDN15,claudin 15,plasma membrane|tight junction|integral component of membrane|,ion transport|calcium-independent cell-cell adhesion|cell junction assembly|cell-cell junction organization|tight junction assembly|,structural molecule activity|identical protein binding|,0,0,0,1,5.1,5.52,5.1,5.35,0.0641,1.9,10
ENSMUSG00000069833,AHNAK,AHNAK nucleoprotein,nucleus|nucleus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|actin cytoskeleton|membrane|T-tubule|vesicle|sarcolemma|sarcolemma|costamere|cell-cell contact zone|membrane raft|extracellular vesicular exosome|,regulation of RNA splicing|protein oligomerization|regulation of voltage-gated calcium channel activity|,protein binding|S100 protein binding|poly(A) RNA binding|structural molecule activity conferring elasticity|,10,-2,3.25,10,-1.8,2.41,-2,5.35,0.0641,-6.2,0.5
ENSMUSG00000034116,VAV1,vav 1 guanine nucleotide exchange factor,cytosol|plasma membrane|,"regulation of transcription, DNA-templated|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|small GTPase mediated signal transduction|blood coagulation|fibroblast growth factor receptor signaling pathway|platelet activation|T cell costimulation|positive regulation of Rac GTPase activity|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|T cell activation|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of GTPase activity|innate immune response|positive regulation of cell adhesion|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|",sequence-specific DNA binding transcription factor activity|guanyl-nucleotide exchange factor activity|guanyl-nucleotide exchange factor activity|protein binding|Rac guanyl-nucleotide exchange factor activity|metal ion binding|,9,-2.5,0.845,10,-2.2,4.78,-2.3,5.35,0.0641,-6,0.1
ENSMUSG00000073058,GM10463,predicted gene 10463,cellular_component|,biological_process|,molecular_function|,0,0,0,1,5.1,5.51,5.1,5.34,0.0645,1.9,10
ENSMUSG00000039187,FANCI,"Fanconi anemia, complementation group I",nucleoplasm|membrane|,DNA repair|cell cycle|positive regulation of protein ubiquitination|,DNA binding|protein binding|DNA polymerase binding|,10,2.2,1.84,10,-2.5,5.33,-2.3,5.34,0.0645,-7.1,2.2
ENSMUSG00000051238,SWSAP1,SWIM-type zinc finger 7 associated protein 1,nucleus|Shu complex|,double-strand break repair via homologous recombination|ATP catabolic process|protein stabilization|,single-stranded DNA binding|protein binding|ATPase activity|,10,-1.8,0.215,10,-2.1,5.35,-2,5.33,0.0647,-5.4,0.2
ENSMUSG00000021039,SNW1,SNW domain containing 1,chromatin|nucleus|nucleoplasm|spliceosomal complex|positive transcription elongation factor complex b|nuclear matrix|catalytic step 2 spliceosome|SMAD3-SMAD4 protein complex|,"negative regulation of transcription from RNA polymerase II promoter|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|gene expression|viral process|positive regulation of transforming growth factor beta receptor signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of mRNA splicing, via spliceosome|retinoic acid receptor signaling pathway|regulation of retinoic acid receptor signaling pathway|positive regulation of neurogenesis|positive regulation of histone H3-K4 methylation|regulation of vitamin D receptor signaling pathway|positive regulation of vitamin D receptor signaling pathway|cellular response to retinoic acid|",transcription coactivator activity|transcription corepressor activity|Notch binding|protein binding|nuclear hormone receptor binding|vitamin D receptor binding|retinoic acid receptor binding|poly(A) RNA binding|SMAD binding|,10,3.3,4.11,9,-2.6,4.52,-2.7,5.32,0.065,-6.4,5.1
ENSMUSG00000035024,NCAPD3,"non-SMC condensin II complex, subunit D3",nuclear condensin complex|nucleoplasm|membrane|nuclear centromeric heterochromatin|germinal vesicle|,mitotic cell cycle|mitotic chromosome condensation|,protein binding|methylated histone binding|,4,2.3,3.48,5,-2.7,4.15,-2.7,5.32,0.065,-6,3.4
ENSMUSG00000031533,MRPS31,mitochondrial ribosomal protein S31,nucleolus|mitochondrion|mitochondrial small ribosomal subunit|,None,structural constituent of ribosome|protein binding|protein domain specific binding|poly(A) RNA binding|,10,-2,1.96,10,-2,3.65,-2,5.32,0.065,-5.5,1.2
ENSMUSG00000029466,ANAPC7,anaphase promoting complex subunit 7,nucleus|nucleoplasm|anaphase-promoting complex|cytosol|,mitotic cell cycle|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,protein phosphatase binding|,10,-5.7,8.18,10,0.7,0.365,-5.6,5.3,0.0653,-10.6,-0.4
ENSMUSG00000020599,RGS9,regulator of G-protein signaling 9,nucleus|cytoplasm|heterotrimeric G-protein complex|plasma membrane|,"dopamine receptor signaling pathway|nervous system development|visual perception|phototransduction, visible light|regulation of G-protein coupled receptor protein signaling pathway|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|intracellular signal transduction|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|response to estrogen|",signal transducer activity|GTPase activator activity|protein complex binding|,1,-4.2,2.33,1,-4.1,3.26,-4.1,5.3,0.0653,-8,-1.3
ENSMUSG00000020409,SLU7,SLU7 splicing factor homolog (S. cerevisiae),nucleus|spliceosomal complex|cytoplasm|membrane|nuclear speck|small nuclear ribonucleoprotein complex|intracellular membrane-bounded organelle|catalytic step 2 spliceosome|,"RNA splicing, via transesterification reactions|alternative mRNA splicing, via spliceosome|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|intracellular protein transport|cellular response to heat|",second spliceosomal transesterification activity|protein binding|zinc ion binding|pre-mRNA 3'-splice site binding|,8,-4,4.37,5,-2.1,1.56,-3.7,5.3,0.0653,-9,0.9
ENSMUSG00000020153,NDUFS7,"NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)",mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|neuron projection|neuronal cell body|synaptic membrane|,"mitochondrial electron transport, NADH to ubiquinone|respiratory electron transport chain|mitochondrial respiratory chain complex I assembly|cellular metabolic process|small molecule metabolic process|","protease binding|NADH dehydrogenase activity|protein binding|NADH dehydrogenase (ubiquinone) activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|metal ion binding|quinone binding|4 iron, 4 sulfur cluster binding|",10,2.9,7.3,9,-0.7,0.166,2.7,5.29,0.0656,-0.6,6.6
ENSMUSG00000074227,SPINT2,"serine peptidase inhibitor, Kunitz type, 2",extracellular region|cytoplasm|integral component of membrane|,cellular component movement|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|,endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|,1,-4.6,2.51,2,4.4,5.99,4.4,5.28,0.0659,-6,9
ENSMUSG00000022471,XRCC6,X-ray repair complementing defective repair in Chinese hamster cells 6,nuclear telomere cap complex|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytosol|membrane|Ku70:Ku80 complex|nonhomologous end joining complex|,"telomere maintenance|DNA ligation|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|transcription, DNA-templated|brain development|viral process|positive regulation of type I interferon production|DNA duplex unwinding|DNA duplex unwinding|V(D)J recombination|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of neurogenesis|cellular hyperosmotic salinity response|cellular response to X-ray|establishment of integrated proviral latency|",DNA binding|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|protein C-terminus binding|transcription regulatory region DNA binding|poly(A) RNA binding|5'-deoxyribose-5-phosphate lyase activity|,10,-1.5,2.58,10,-2,3.04,-1.7,5.27,0.0663,-7.2,3.4
ENSMUSG00000008958,VPS72,vacuolar protein sorting 72 homolog (S. cerevisiae),nucleus|nucleoplasm|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|chromatin organization|transcription, DNA-templated|chromatin modification|somatic stem cell maintenance|",DNA binding|protein binding|,10,-3.8,0.704,10,-3.1,4.86,-3.7,5.27,0.0663,-8.2,0.4
ENSMUSG00000000751,RPA1,"replication protein A1, 70kDa",lateral element|male germ cell nucleus|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication factor A complex|cytoplasm|actin cytoskeleton|PML body|PML body|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage removal|telomere maintenance via recombination|telomere maintenance|telomere maintenance|double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|in utero embryonic development|DNA replication|DNA replication|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|double-strand break repair|DNA recombination|meiotic nuclear division|positive regulation of cell proliferation|hemopoiesis|telomere maintenance via semi-conservative replication|homeostasis of number of cells within a tissue|",chromatin binding|damaged DNA binding|single-stranded DNA binding|protein binding|metal ion binding|,8,-2.5,0.759,7,-4.4,5.35,-3.4,5.19,0.0684,-11,-0.1
ENSMUSG00000056214,PARD6G,par-6 family cell polarity regulator gamma,cytosol|plasma membrane|tight junction|protein complex|,cell cycle|cell junction assembly|cell-cell junction organization|cell division|tight junction assembly|,protein binding|,10,-2.7,6.91,10,0.5,0.0177,-1.5,5.18,0.0687,-10.9,0.5
ENSMUSG00000021266,WARS,tryptophanyl-tRNA synthetase,nucleus|cytoplasm|cytoplasm|cytosol|extracellular vesicular exosome|,angiogenesis|translation|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|negative regulation of cell proliferation|gene expression|regulation of angiogenesis|,tryptophan-tRNA ligase activity|tryptophan-tRNA ligase activity|protein binding|ATP binding|,9,-1.8,1.17,9,-2.8,4.39,-2,5.17,0.0691,-6.2,0.4
ENSMUSG00000022034,ESCO2,establishment of sister chromatid cohesion N-acetyltransferase 2,chromatin|nucleus|nucleoplasm|Golgi apparatus|,mitotic cell cycle|regulation of DNA replication|post-translational protein acetylation|,"transferase activity, transferring acyl groups|metal ion binding|",9,-4.9,6.04,10,-1.7,1.85,-4.5,5.17,0.0691,-9,1.1
ENSMUSG00000031843,MPHOSPH6,M-phase phosphoprotein 6,nuclear exosome (RNase complex)|exosome (RNase complex)|exosome (RNase complex)|nucleus|nucleolus|cytoplasm|,mitotic M phase|maturation of 5.8S rRNA|,RNA binding|protein binding|,8,-1.9,1.7,8,-2.5,3.92,-2.3,5.17,0.0691,-7.5,9
ENSMUSG00000090112,SHPRH,"SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase",nucleosome|nucleus|,protein polyubiquitination|DNA repair|nucleosome assembly|,DNA binding|helicase activity|ubiquitin-protein transferase activity|ATP binding|zinc ion binding|ligase activity|,10,1.3,1.7,10,-2.9,7.38,-2.7,5.16,0.0694,-7.2,1.4
ENSMUSG00000074123,7420426K07RIK,RIKEN cDNA 7420426K07 gene,cellular_component|,biological_process|,molecular_function|,1,5.3,5.96,1,-2.6,1.29,5.3,5.15,0.0697,-1.8,11
ENSMUSG00000033538,CASP4,"caspase 4, apoptosis-related cysteine peptidase",cytoplasm|mitochondrion|endoplasmic reticulum membrane|IPAF inflammasome complex|NLRP3 inflammasome complex|AIM2 inflammasome complex|,proteolysis|apoptotic process|regulation of apoptotic process|regulation of inflammatory response|execution phase of apoptosis|,cysteine-type endopeptidase activity|,10,-2.6,3.56,10,-2.7,1.86,-2.6,5.14,0.07,-6.1,0.5
ENSMUSG00000018800,ABCA5,"ATP-binding cassette, sub-family A (ABC1), member 5",Golgi membrane|lysosome|lysosomal membrane|late endosome|integral component of membrane|late endosome membrane|,ATP catabolic process|negative regulation of macrophage derived foam cell differentiation|cholesterol efflux|high-density lipoprotein particle remodeling|reverse cholesterol transport|,ATP binding|ATPase activity|,10,-3.5,3.97,10,-2,2.23,-3.2,5.14,0.07,-8.7,5.6
ENSMUSG00000035673,SBNO2,strawberry notch homolog 2 (Drosophila),cellular_component|,"macrophage activation involved in immune response|transcription, DNA-templated|negative regulation of transcription, DNA-templated|regulation of inflammatory response|",None,10,-2.1,1.91,10,-2.1,3.49,-2.1,5.13,0.0702,-5.4,0.1
ENSMUSG00000033174,MGLL,monoglyceride lipase,endoplasmic reticulum membrane|plasma membrane|synapse|,lipid metabolic process|fatty acid biosynthetic process|phospholipid metabolic process|inflammatory response|blood coagulation|regulation of signal transduction|arachidonic acid metabolic process|triglyceride catabolic process|triglyceride catabolic process|platelet activation|acylglycerol acyl-chain remodeling|small molecule metabolic process|acylglycerol catabolic process|glycerophospholipid biosynthetic process|regulation of inflammatory response|regulation of sensory perception of pain|long term synaptic depression|regulation of endocannabinoid signaling pathway|,lysophospholipase activity|lipid binding|protein homodimerization activity|acylglycerol lipase activity|acylglycerol lipase activity|,10,7.8,5.63,10,2.9,2.99,7.5,5.13,0.0702,-1.4,16
ENSMUSG00000042712,WBP5,WW domain binding protein 5,None,None,WW domain binding|,10,-4,2.15,10,-1.6,3.51,-1.7,5.13,0.0702,-6.3,0.1
ENSMUSG00000057789,BAK1,BCL2-antagonist/killer 1,mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|endoplasmic reticulum|cytosol|integral component of mitochondrial outer membrane|pore complex|,B cell homeostasis|B cell apoptotic process|release of cytochrome c from mitochondria|release of cytochrome c from mitochondria|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|apoptotic process|brain development|aging|mitochondrial fusion|cell proliferation|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|response to fungus|response to mycotoxin|response to UV-C|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|positive regulation of calcium ion transport into cytosol|negative regulation of gene expression|response to organic cyclic compound|endocrine pancreas development|organ regeneration|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|negative regulation of peptidyl-serine phosphorylation|cellular response to UV|cellular response to UV|limb morphogenesis|response to drug|response to hydrogen peroxide|positive regulation of apoptotic process|regulation of protein homodimerization activity|regulation of protein heterodimerization activity|fibroblast apoptotic process|response to ethanol|positive regulation of proteolysis|regulation of mitochondrial membrane permeability|post-embryonic camera-type eye morphogenesis|regulation of cell cycle|regulation of mitochondrial membrane potential|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|thymocyte apoptotic process|cellular response to mechanical stimulus|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in patterning of blood vessels|,protein binding|heat shock protein binding|identical protein binding|protein homodimerization activity|metal ion binding|protein heterodimerization activity|chaperone binding|BH domain binding|,10,-5.1,1.48,9,-2.3,5.12,-2.6,5.12,0.0705,-8.2,0.6
ENSMUSG00000024905,MTL5,"metallothionein-like 5, testis-specific (tesmin)",nucleus|cytoplasm|,cellular metal ion homeostasis|multicellular organismal development|spermatogenesis|response to metal ion|cell differentiation|,metal ion binding|,10,-6.3,3.99,10,-1.9,4.2,-2.6,5.12,0.0705,-9.5,0
ENSMUSG00000038545,CUL7,cullin 7,nucleus|anaphase-promoting complex|cytoplasm|Golgi apparatus|centrosome|cytosol|Cul7-RING ubiquitin ligase complex|perinuclear region of cytoplasm|3M complex|,microtubule cytoskeleton organization|mitotic cytokinesis|vasculogenesis|epithelial to mesenchymal transition|placenta development|proteolysis|ubiquitin-dependent protein catabolic process|activation of signaling protein activity involved in unfolded protein response|Golgi organization|regulation of mitosis|viral process|protein ubiquitination|protein ubiquitination|protein ubiquitination|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|positive regulation of dendrite morphogenesis|positive regulation of dendrite morphogenesis|,protein binding|ubiquitin protein ligase binding|,9,1.3,1.66,10,-4.4,5.58,-4.1,5.12,0.0705,-9.2,0.9
ENSMUSG00000021902,PHF7,PHD finger protein 7,nucleus|Golgi apparatus|plasma membrane|,None,zinc ion binding|,0,0,0,1,5,5.29,5,5.11,0.0708,1.7,10
ENSMUSG00000019295,TMEM129,"transmembrane protein 129, E3 ubiquitin protein ligase",cellular_component|integral component of membrane|,biological_process|,molecular_function|,1,-3.8,2.13,1,-4.5,3.35,-4.4,5.1,0.071,-9,-1.4
ENSMUSG00000024660,INCENP,inner centromere protein antigens 135/155kDa,"chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|lateral element|central element|centromeric heterochromatin|spindle|cytosol|microtubule|chromocenter|midbody|protein complex|",mitotic cell cycle|cytokinesis|chromosome segregation|mitotic nuclear division|,protein binding|,7,-2.3,1.36,9,-2.9,4.25,-2.8,5.1,0.071,-8.7,7.6
ENSMUSG00000024974,SMC3,structural maintenance of chromosomes 3,"chromosome, centromeric region|chromatin|lateral element|spindle pole|basement membrane|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|cohesin complex|nuclear matrix|meiotic cohesin complex|nuclear meiotic cohesin complex|",mitotic cell cycle|regulation of DNA replication|DNA repair|mitotic spindle organization|sister chromatid cohesion|sister chromatid cohesion|mitotic nuclear division|meiotic nuclear division|signal transduction|stem cell maintenance|negative regulation of DNA endoreduplication|,chromatin binding|microtubule motor activity|protein binding|ATP binding|mediator complex binding|dynein binding|protein heterodimerization activity|,6,-1.2,0.926,6,-2.9,4.72,-2.9,5.09,0.0713,-6.6,-0.3
ENSMUSG00000020429,IGFBP1,insulin-like growth factor binding protein 1,extracellular region|extracellular space|,activation of signaling protein activity involved in unfolded protein response|signal transduction|insulin receptor signaling pathway|positive regulation of cell growth|endoplasmic reticulum unfolded protein response|tissue regeneration|cellular protein metabolic process|,insulin-like growth factor binding|,9,-4.4,4.17,10,-2.3,2.24,-4.2,5.08,0.0715,-8.1,0.3
ENSMUSG00000031311,NONO,"non-POU domain containing, octamer-binding",nucleus|nucleus|membrane|nuclear matrix|nuclear speck|paraspeckles|,"DNA repair|DNA recombination|transcription, DNA-templated|mRNA processing|circadian rhythm|RNA splicing|regulation of circadian rhythm|negative regulation of transcription, DNA-templated|",nucleotide binding|core promoter binding|protein binding|identical protein binding|poly(A) RNA binding|,10,-6.2,3.05,10,-1.6,3.14,-1.2,5.07,0.0718,-9.3,0.8
ENSMUSG00000008690,NCAPH2,"non-SMC condensin II complex, subunit H2",nucleoplasm|chromosome|membrane|,mitotic cell cycle|chromosome condensation|,protein binding|,10,-2.3,2.15,9,-3.9,3.53,-2.6,5.05,0.0723,-8.5,0.6
ENSMUSG00000040599,MIS12,MIS12 kinetochore complex component,MIS12/MIND type complex|nucleus|cytosol|,mitotic cell cycle|chromosome segregation|mitotic nuclear division|kinetochore assembly|,protein binding|,4,-5.3,3.21,5,-2,2.92,-3.4,5.04,0.0724,-10.3,-0.5
ENSMUSG00000021109,HIF1A,"hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)",nucleus|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|cytosol|cytosol|motile cilium|,"angiogenesis|response to hypoxia|response to hypoxia|neural crest cell migration|epithelial to mesenchymal transition|embryonic placenta development|B-1 B cell homeostasis|positive regulation of endothelial cell proliferation|heart looping|positive regulation of neuroblast proliferation|connective tissue replacement involved in inflammatory response wound healing|outflow tract morphogenesis|cardiac ventricle morphogenesis|lactate metabolic process|regulation of transcription, DNA-templated|cellular iron ion homeostasis|signal transduction|Notch signaling pathway|lactation|visual learning|regulation of gene expression|vascular endothelial growth factor production|positive regulation vascular endothelial growth factor production|positive regulation vascular endothelial growth factor production|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|response to muscle activity|axon transport of mitochondrion|neural fold elevation formation|cerebral cortex development|negative regulation of bone mineralization|positive regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of TOR signaling|oxygen homeostasis|positive regulation of chemokine production|regulation of transforming growth factor beta2 production|collagen metabolic process|embryonic hemopoiesis|positive regulation of insulin secretion involved in cellular response to glucose stimulus|hemoglobin biosynthetic process|glucose homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of erythrocyte differentiation|positive regulation of angiogenesis|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of growth|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|muscle cell cellular homeostasis|positive regulation of hormone biosynthetic process|digestive tract morphogenesis|positive regulation of nitric-oxide synthase activity|cartilage development|elastin metabolic process|intestinal epithelial cell maturation|epithelial cell differentiation involved in mammary gland alveolus development|retina vasculature development in camera-type eye|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of chemokine-mediated signaling pathway|negative regulation of thymocyte apoptotic process|cellular response to interleukin-1|cellular response to hypoxia|cellular response to hypoxia|cellular response to hypoxia|dopaminergic neuron differentiation|negative regulation of mesenchymal cell apoptotic process|",transcription factor binding transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|signal transducer activity|protein binding|transcription factor binding|enzyme binding|protein kinase binding|ubiquitin protein ligase binding|histone acetyltransferase binding|nuclear hormone receptor binding|histone deacetylase binding|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|protein heterodimerization activity|Hsp90 protein binding|,10,-3.5,1.97,10,-4.6,3.57,-3.6,5.04,0.0724,-9.8,4
ENSMUSG00000027082,TFPI,tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor),extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|organelle membrane|anchored component of membrane|,"blood coagulation|blood coagulation, extrinsic pathway|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|",endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|,10,-1.4,0.649,10,-6,6.04,-4.8,5.04,0.0724,-11.2,-0.4
ENSMUSG00000014668,CHFR,"checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase",nucleus|PML body|,protein polyubiquitination|ubiquitin-dependent protein catabolic process|mitotic nuclear division|mitotic cell cycle checkpoint|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|,nucleotide binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,8,-2.5,5.1,10,-0.9,0.741,-2.2,5.04,0.0724,-8,10.1
ENSMUSG00000023868,PDE10A,phosphodiesterase 10A,cytosol|,cAMP catabolic process|signal transduction|blood coagulation|regulation of protein kinase A signaling|regulation of cAMP-mediated signaling|cGMP catabolic process|,"3',5'-cyclic-nucleotide phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cAMP binding|cAMP binding|cGMP binding|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|",10,1.1,2.25,10,-2.9,5.66,-1.7,5.04,0.0724,-5.4,2
ENSMUSG00000028800,HDAC1,histone deacetylase 1,histone deacetylase complex|nuclear chromatin|nucleus|nucleoplasm|nucleoplasm|cytoplasm|cytosol|Sin3 complex|NuRD complex|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|chromatin remodeling|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|protein deacetylation|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|blood coagulation|positive regulation of cell proliferation|epidermal cell differentiation|gene expression|positive regulation of receptor biosynthetic process|viral process|chromatin modification|histone deacetylation|circadian regulation of gene expression|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation by host of viral transcription|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|negative regulation of androgen receptor signaling pathway|hair follicle placode formation|eyelid development in camera-type eye|fungiform papilla formation|histone H3 deacetylation|histone H4 deacetylation|",transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|core promoter binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity|histone deacetylase activity|histone deacetylase activity|histone deacetylase activity|protein binding|transcription factor binding|transcription factor binding|deacetylase activity|enzyme binding|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|protein deacetylase activity|activating transcription factor binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD-dependent histone deacetylase activity (H3-K18 specific)|,9,-4.2,7.31,9,-0.6,0.116,-4.1,5.02,0.0729,-8.7,0.1
ENSMUSG00000020423,BTG2,"BTG family, member 2",extracellular vesicular exosome|,"DNA repair|transcription, DNA-templated|protein methylation|cellular response to DNA damage stimulus|negative regulation of cell proliferation|associative learning|response to mechanical stimulus|anterior/posterior pattern specification|response to organic cyclic compound|negative regulation of translation|dentate gyrus development|central nervous system neuron development|neuron projection development|skeletal muscle cell differentiation|response to peptide hormone|negative regulation of neuron apoptotic process|positive regulation of transcription from RNA polymerase II promoter|response to electrical stimulus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of neural precursor cell proliferation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protein binding|,9,2.5,2.92,10,3,2.48,2.7,5.01,0.0733,-5.5,6.5
ENSMUSG00000037544,DLGAP5,"discs, large (Drosophila) homolog-associated protein 5",nucleus|nucleus|cytoplasm|microtubule organizing center|spindle pole centrosome|spindle pole centrosome|,mitotic M phase|mitotic M phase|mitotic chromosome movement towards spindle pole|cell-cell signaling|cell proliferation|dephosphorylation|dephosphorylation|positive regulation of mitotic metaphase/anaphase transition|,phosphoprotein phosphatase activity|phosphoprotein phosphatase activity|protein binding|,10,-4.7,4.51,10,-1.5,2.15,-3.2,5.01,0.0733,-8,0.1
ENSMUSG00000026786,APBB1IP,"amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein",cytosol|cytoskeleton|plasma membrane|focal adhesion|lamellipodium|,signal transduction|blood coagulation|platelet activation|,None,10,-2.9,3.52,10,-3.8,1.86,-3,5.01,0.0733,-7.7,0.5
ENSMUSG00000039706,LDB2,LIM domain binding 2,nucleus|transcription factor complex|,hair follicle development|epithelial structure maintenance|somatic stem cell maintenance|positive regulation of cellular component biogenesis|positive regulation of transcription from RNA polymerase II promoter|,transcription cofactor activity|enzyme binding|LIM domain binding|,1,2.4,2.22,2,3.7,3.35,3.6,4.99,0.074,0.9,8
ENSMUSG00000039176,POLG,"polymerase (DNA directed), gamma",mitochondrion|mitochondrial inner membrane|gamma DNA polymerase complex|mitochondrial nucleoid|extracellular vesicular exosome|,"DNA metabolic process|DNA-dependent DNA replication|mitochondrial DNA replication|base-excision repair, gap-filling|aging|cell death|nucleic acid phosphodiester bond hydrolysis|",protease binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|exonuclease activity|protein binding|,10,-3.5,3.04,10,-2.6,2.44,-3,4.98,0.0743,-6.9,0.5
ENSMUSG00000028932,PSMC2,"proteasome (prosome, macropain) 26S subunit, ATPase, 2",proteasome complex|cytoplasmic mRNA processing body|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|proteasome accessory complex|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|osteoblast differentiation|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|ATP binding|ATPase activity|,9,1.9,3.66,8,2.5,1.69,2.3,4.98,0.0743,-0.5,5.7
ENSMUSG00000022023,WBP4,WW domain binding protein 4,nucleus|spliceosomal complex|plasma membrane|nuclear speck|,"mRNA cis splicing, via spliceosome|",nucleic acid binding|protein binding|zinc ion binding|proline-rich region binding|,10,-3.3,5.08,9,-1.3,1.98,-2.2,4.96,0.0749,-6,0
ENSMUSG00000029003,MAD2L2,MAD2 mitotic arrest deficient-like 2 (yeast),nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|spindle|zeta DNA polymerase complex|,"negative regulation of transcription from RNA polymerase II promoter|regulation of cell growth|DNA repair|double-strand break repair|transcription, DNA-templated|actin filament organization|mitotic nuclear division|mitotic spindle assembly checkpoint|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription by competitive promoter binding|positive regulation of peptidyl-serine phosphorylation|negative regulation of protein catabolic process|DNA damage response, signal transduction resulting in transcription|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-templated|negative regulation of mitotic anaphase-promoting complex activity|negative regulation of canonical Wnt signaling pathway|negative regulation of cell-cell adhesion mediated by cadherin|negative regulation of transcription regulatory region DNA binding|",RNA polymerase II activating transcription factor binding|protein binding|JUN kinase binding|,10,-0.7,0.592,10,-2.4,5.11,-2.1,4.96,0.0749,-7.9,0.9
ENSMUSG00000000817,FASL,"Fas ligand (TNF superfamily, member 6)",extracellular region|extracellular space|nucleus|lysosome|plasma membrane|caveola|external side of plasma membrane|membrane|integral component of membrane|cytoplasmic membrane-bounded vesicle|cytoplasmic vesicle|membrane raft|perinuclear region of cytoplasm|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory cell apoptotic process|immune response|positive regulation of cell proliferation|extrinsic apoptotic signaling pathway via death domain receptors|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of angiogenesis|cellular chloride ion homeostasis|positive regulation of apoptotic process|positive regulation of neuron apoptotic process|positive regulation of epidermal growth factor receptor signaling pathway|retinal cell programmed cell death|endosomal lumen acidification|T cell apoptotic process|necroptotic process|apoptotic signaling pathway|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of endothelial cell apoptotic process|",death receptor binding|cytokine activity|tumor necrosis factor receptor binding|,9,2.5,2.48,10,-2.3,6.38,-2.2,4.95,0.0752,-7,4.3
ENSMUSG00000078154,GM12184,CDK2 (cyclin-dependent kinase 2)-associated protein 1 pseudogene,cellular_component|,biological_process|,molecular_function|,3,1.8,1.27,3,4,4.8,3.7,4.95,0.0752,-0.6,8
ENSMUSG00000012777,ACPT,"acid phosphatase, testicular",integral component of membrane|,dephosphorylation|,acid phosphatase activity|,1,5.3,5.75,1,-2.5,1.14,5.2,4.93,0.0758,-1.9,11
ENSMUSG00000001930,VWF,von Willebrand factor,extracellular region|extracellular region|extracellular region|proteinaceous extracellular matrix|endoplasmic reticulum|external side of plasma membrane|extracellular matrix|platelet alpha granule|platelet alpha granule lumen|Weibel-Palade body|extracellular vesicular exosome|,"liver development|placenta development|platelet degranulation|cell adhesion|blood coagulation|blood coagulation|blood coagulation, intrinsic pathway|hemostasis|response to wounding|platelet activation|platelet activation|platelet activation|extracellular matrix organization|cell-substrate adhesion|protein homooligomerization|",glycoprotein binding|protease binding|protease binding|integrin binding|protein binding|collagen binding|immunoglobulin binding|identical protein binding|protein homodimerization activity|protein N-terminus binding|chaperone binding|,10,-2.9,5.54,10,-0.8,0.574,-1.2,4.93,0.0758,-9.6,0.2
ENSMUSG00000056167,CNOT10,"CCR4-NOT transcription complex, subunit 10",nucleus|cytosol|membrane|CCR4-NOT complex|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translation|gene expression|RNA metabolic process|mRNA metabolic process|gene silencing by RNA|",protein binding|,1,-3.5,1.93,1,-3.8,3.29,-3.8,4.93,0.0758,-7,-0.7
ENSMUSG00000024528,SRFBP1,serum response factor binding protein 1,nucleus|perinuclear region of cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",poly(A) RNA binding|,1,5,5.1,0,0,0,5,4.92,0.0761,1.8,11
ENSMUSG00000029535,TRIAP1,TP53 regulated inhibitor of apoptosis 1,mitochondrion|mitochondrial intermembrane space|protein complex|perinuclear region of cytoplasm|,"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|phospholipid transport|DNA damage response, signal transduction by p53 class mediator|cellular response to UV|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription from RNA polymerase II promoter|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of phospholipid transport|",p53 binding|protein binding|phosphatidic acid transporter activity|,6,-2,1.4,6,-3.5,3.79,-3.5,4.91,0.0764,-7.8,-0.6
ENSMUSG00000032244,FEM1B,fem-1 homolog b (C. elegans),nucleus|cytoplasm|,apoptotic process|protein ubiquitination|regulation of ubiquitin-protein transferase activity|branching involved in prostate gland morphogenesis|epithelial cell maturation involved in prostate gland development|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of DNA damage checkpoint|,ubiquitin-protein transferase activity|death receptor binding|death receptor binding|protein binding|,10,3.1,6.97,10,-0.3,0.0805,2.6,4.91,0.0764,-0.4,7.2
ENSMUSG00000028271,GTF2B,general transcription factor IIB,nucleoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|",core promoter binding|protein binding|transcription factor binding|zinc ion binding|TBP-class protein binding|thyroid hormone receptor binding|,5,4.1,5.27,8,-1.6,3.13,3.7,4.9,0.0767,-4.1,9
ENSMUSG00000002343,ARMC6,armadillo repeat containing 6,None,None,None,10,-1.7,2.74,10,-1.4,2.5,-1.6,4.89,0.0769,-5.9,0.8
ENSMUSG00000033166,DIS3,DIS3 exosome endoribonuclease and 3'-5' exoribonuclease,nuclear exosome (RNase complex)|exosome (RNase complex)|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|rRNA processing|gene expression|RNA metabolic process|mRNA metabolic process|rRNA catabolic process|positive regulation of GTPase activity|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|CUT catabolic process|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, exonucleolytic|",3'-5'-exoribonuclease activity|RNA binding|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|,8,-1.3,0.94,9,-2.6,4.7,-2.4,4.89,0.0769,-7.2,4.2
ENSMUSG00000059439,BCAS3,breast carcinoma amplified sequence 3,nucleus|cytoplasm|cell periphery|,None,protein binding|,10,-1,1.38,10,-1.7,3.92,-1.6,4.88,0.0773,-4.7,0
ENSMUSG00000024382,ERCC3,excision repair cross-complementation group 3,nucleus|nucleus|nucleoplasm|holo TFIIH complex|holo TFIIH complex|,"nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA damage removal|response to hypoxia|ATP catabolic process|DNA topological change|DNA repair|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|apoptotic process|response to oxidative stress|protein localization|response to UV|UV protection|gene expression|viral process|nucleotide-excision repair, DNA incision|hair cell differentiation|positive regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of mitotic cell cycle phase transition|",DNA binding|damaged DNA binding|ATP-dependent DNA helicase activity|protein kinase activity|protein binding|ATP binding|GTP binding|protein C-terminus binding|DNA-dependent ATPase activity|DNA-dependent ATPase activity|transcription factor binding|RNA polymerase II carboxy-terminal domain kinase activity|ATPase activity|dATP binding|peptide binding|3'-5' DNA helicase activity|3'-5' DNA helicase activity|protein N-terminus binding|,10,-4.2,3.08,10,-3,2.39,-4,4.86,0.078,-8.5,0.9
ENSMUSG00000037348,PAQR7,progestin and adipoQ receptor family member VII,plasma membrane|integral component of membrane|,multicellular organismal development|steroid hormone mediated signaling pathway|oogenesis|response to steroid hormone|,steroid hormone receptor activity|steroid binding|,0,0,0,1,4.9,5.03,4.9,4.86,0.078,1.4,10
ENSMUSG00000049878,RLF,rearranged L-myc fusion,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|DNA integration|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|chromosome organization|chromosome organization|",DNA binding|protein binding|zinc ion binding|,0,0,0,1,-5.2,5.01,-5.2,4.84,0.0786,-10,-1.2
ENSMUSG00000005370,MSH6,mutS homolog 6,nuclear chromosome|nuclear chromatin|nucleus|cytoplasm|Golgi apparatus|plasma membrane|MutSalpha complex|intracellular membrane-bounded organelle|,meiotic mismatch repair|meiotic mismatch repair|ATP catabolic process|ATP catabolic process|DNA repair|mismatch repair|mismatch repair|mismatch repair|reciprocal meiotic recombination|determination of adult lifespan|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|response to UV|somatic hypermutation of immunoglobulin genes|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|isotype switching|isotype switching|negative regulation of DNA recombination|positive regulation of helicase activity|intrinsic apoptotic signaling pathway|,magnesium ion binding|four-way junction DNA binding|chromatin binding|double-stranded DNA binding|protein binding|protein binding|ATP binding|DNA-dependent ATPase activity|ATPase activity|mismatched DNA binding|mismatched DNA binding|guanine/thymine mispair binding|single guanine insertion binding|single thymine insertion binding|oxidized purine DNA binding|MutLalpha complex binding|methylated histone binding|ADP binding|,10,-0.8,0.704,10,-3.7,6,-3.8,4.84,0.0786,-10.2,0
ENSMUSG00000057132,RPGRIP1,retinitis pigmentosa GTPase regulator interacting protein 1,axoneme|nonmotile primary cilium|,visual perception|eye photoreceptor cell development|response to stimulus|retina development in camera-type eye|,protein binding|,9,-0.4,0.247,8,-3.1,5.16,-2.8,4.84,0.0786,-7.9,0
ENSMUSG00000027506,TPD52,tumor protein D52,cytoplasm|endoplasmic reticulum|perinuclear region of cytoplasm|,anatomical structure morphogenesis|B cell differentiation|secretion|,calcium ion binding|protein binding|protein homodimerization activity|protein heterodimerization activity|,10,-3.2,3.38,10,-2.2,1.97,-2.8,4.83,0.0791,-7.4,0.2
ENSMUSG00000015709,ARNT2,aryl-hydrocarbon receptor nuclear translocator 2,nucleus|transcription factor complex|cytoplasm|,"response to hypoxia|in utero embryonic development|transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|central nervous system development|positive regulation of cell proliferation|response to estradiol|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|aryl hydrocarbon receptor binding|protein heterodimerization activity|protein heterodimerization activity|,10,1.8,3.56,10,2.1,1.58,2,4.82,0.0796,-4.7,5.2
ENSMUSG00000002748,BAZ1B,"bromodomain adjacent to zinc finger domain, 1B",condensed chromosome|centromeric heterochromatin|nuclear replication fork|,"heart morphogenesis|double-strand break repair|chromatin assembly or disassembly|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|histone phosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|chromatin-mediated maintenance of transcription|positive regulation of receptor activity|",chromatin binding|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|zinc ion binding|histone kinase activity|lysine-acetylated histone binding|vitamin D receptor activator activity|,9,-1.3,2.55,10,-3.1,4.17,-2.5,4.82,0.0796,-10.6,0.1
ENSMUSG00000017830,DHX58,DEXH (Asp-Glu-X-His) box polypeptide 58,cytoplasm|,metabolic process|response to virus|viral process|negative regulation of type I interferon production|positive regulation of type I interferon production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|negative regulation of RIG-I signaling pathway|innate immune response|regulation of innate immune response|negative regulation of innate immune response|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway|,DNA binding|double-stranded RNA binding|single-stranded RNA binding|helicase activity|protein binding|ATP binding|zinc ion binding|,1,-1.4,0.591,1,-5.2,4.95,-5.1,4.81,0.0799,-10,-1.1
ENSMUSG00000028447,DCTN3,dynactin 3 (p22),condensed chromosome kinetochore|centrosome|spindle|cytosol|dynactin complex|midbody|cleavage furrow|perinuclear region of cytoplasm|,G2/M transition of mitotic cell cycle|mitotic cell cycle|cytokinesis|microtubule-based process|mitotic nuclear division|antigen processing and presentation of exogenous peptide antigen via MHC class II|,structural molecule activity|protein binding|,9,-3,2.65,9,-2.9,2.42,-3,4.79,0.0805,-7.1,0.8
ENSMUSG00000025407,GLI1,GLI family zinc finger 1,nucleus|cytoplasm|cytosol|intracellular membrane-bounded organelle|primary cilium|,"osteoblast differentiation|transcription from RNA polymerase II promoter|smoothened signaling pathway|smoothened signaling pathway|spermatogenesis|ventral midline development|positive regulation of cell proliferation|regulation of smoothened signaling pathway|epidermal cell differentiation|dorsal/ventral pattern formation|proximal/distal pattern formation|cerebellar cortex morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|pituitary gland development|lung development|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|digestive tract morphogenesis|notochord regression|negative regulation of canonical Wnt signaling pathway|",DNA binding|chromatin binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|microtubule binding|transcription regulatory region DNA binding|metal ion binding|,10,-2.4,3.57,10,-3.3,1.8,-2.6,4.78,0.0808,-7.5,0.3
ENSMUSG00000026921,EGFL7,"EGF-like-domain, multiple 7",extracellular region|extracellular space|,angiogenesis|blood vessel development|vasculogenesis|positive regulation of endothelial cell proliferation|cell adhesion|negative regulation of cell migration|negative regulation of Notch signaling pathway|,Notch binding|calcium ion binding|,1,2.8,2.86,1,2.8,2.2,2.8,4.78,0.0808,0.3,6
ENSMUSG00000027070,LRP2,low density lipoprotein receptor-related protein 2,lysosome|lysosomal membrane|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|coated pit|integral component of membrane|apical plasma membrane|endocytic vesicle|brush border membrane|receptor complex|extracellular vesicular exosome|,"retinoid metabolic process|protein glycosylation|lipid metabolic process|endocytosis|receptor-mediated endocytosis|phototransduction, visible light|steroid metabolic process|cell proliferation|forebrain development|vitamin D metabolic process|small molecule metabolic process|",calcium ion binding|protein binding|SH3 domain binding|,10,-3.7,7.72,10,0.5,0.0591,-3.6,4.78,0.0808,-7.3,0.3
ENSMUSG00000035726,SUPT16,suppressor of Ty 16,nucleus|chromosome|,"DNA replication|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|",poly(A) RNA binding|,5,-4.2,5.32,5,3.2,2.34,-4,4.77,0.0811,-9,5.5
ENSMUSG00000053141,PTPRT,"protein tyrosine phosphatase, receptor type, T",plasma membrane|cell surface|integral component of membrane|,protein dephosphorylation|cell adhesion|homophilic cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|,protein tyrosine phosphatase activity|protein binding|beta-catenin binding|thiolester hydrolase activity|alpha-catenin binding|gamma-catenin binding|cadherin binding|alpha-actinin binding|delta-catenin binding|,10,2.5,4.88,10,-1.9,1.84,2.5,4.76,0.0814,-2.7,6.2
ENSMUSG00000027852,NRAS,neuroblastoma RAS viral (v-ras) oncogene homolog,Golgi membrane|plasma membrane|membrane|extracellular vesicular exosome|,"MAPK cascade|activation of MAPKK activity|GTP catabolic process|epidermal growth factor receptor signaling pathway|small GTPase mediated signal transduction|Ras protein signal transduction|axon guidance|blood coagulation|positive regulation of cell proliferation|insulin receptor signaling pathway|visual learning|fibroblast growth factor receptor signaling pathway|actin cytoskeleton organization|regulation of synaptic transmission, GABAergic|positive regulation of Rac protein signal transduction|Fc-epsilon receptor signaling pathway|negative regulation of neuron apoptotic process|innate immune response|neurotrophin TRK receptor signaling pathway|regulation of long-term neuronal synaptic plasticity|leukocyte migration|striated muscle cell differentiation|",GTP binding|protein complex binding|,10,-2.9,4.04,10,-1.1,1.91,-1.9,4.75,0.0817,-6.6,0.3
ENSMUSG00000090272,MNDAL,myeloid nuclear differentiation antigen like,nucleus|nucleus|nucleolus|cytoplasm|membrane|,negative regulation of cell growth|regulation of growth|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,10,-2.5,2.6,10,-2.2,2.47,-2.4,4.75,0.0817,-7.1,0.3
ENSMUSG00000005968,TUFT1,tuftelin 1,extracellular region|cytoplasm|,bone mineralization|odontogenesis|,structural constituent of tooth enamel|,9,5.9,2.87,9,-3.1,3.5,-2.6,4.74,0.082,-9.7,8
ENSMUSG00000005410,MCM5,minichromosome maintenance complex component 5,nucleus|nucleoplasm|membrane|MCM complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA duplex unwinding|,DNA binding|DNA helicase activity|protein binding|ATP binding|,7,3.2,3.04,7,6.2,3.74,5.8,4.74,0.082,-1.1,13
ENSMUSG00000019977,HBS1L,HBS1-like translational GTPase,membrane|extracellular vesicular exosome|,GTP catabolic process|translation|translational elongation|signal transduction|,translation elongation factor activity|GTPase activity|GTP binding|,2,-5,1.9,1,-4.2,3.26,-4.8,4.73,0.0822,-10,-1.4
ENSMUSG00000055737,GHR,growth hormone receptor,extracellular region|extracellular space|extracellular space|nucleus|mitochondrion|plasma membrane|integral component of plasma membrane|cell surface|integral component of membrane|extrinsic component of membrane|neuronal cell body|receptor complex|growth hormone receptor complex|,activation of MAPK activity|allantoin metabolic process|citrate metabolic process|2-oxoglutarate metabolic process|succinate metabolic process|oxaloacetate metabolic process|isoleucine metabolic process|valine metabolic process|creatine metabolic process|fatty acid metabolic process|endocytosis|JAK-STAT cascade|hormone-mediated signaling pathway|cytokine-mediated signaling pathway|taurine metabolic process|receptor internalization|response to food|response to estradiol|cellular response to insulin stimulus|cellular response to hormone stimulus|regulation of multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|activation of JAK2 kinase activity|response to morphine|multicellular organismal metabolic process|positive regulation of cell differentiation|creatinine metabolic process|response to cycloheximide|insulin-like growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|response to glucocorticoid|cartilage development involved in endochondral bone morphogenesis|growth hormone receptor signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|response to interleukin-1|negative regulation of neuron death|,growth hormone receptor activity|protein binding|peptide hormone binding|growth factor binding|protein kinase binding|protein phosphatase binding|SH2 domain binding|protein homodimerization activity|proline-rich region binding|,10,1.7,4.08,10,-2.3,3.99,-2.6,4.72,0.0827,-5.6,3.1
ENSMUSG00000027690,SLC2A2,"solute carrier family 2 (facilitated glucose transporter), member 2",cytoplasm|plasma membrane|integral component of plasma membrane|brush border|membrane|,carbohydrate metabolic process|energy reserve metabolic process|hexose transport|glucose transport|endocrine pancreas development|hexose transmembrane transport|small molecule metabolic process|regulation of insulin secretion|transmembrane transport|dehydroascorbic acid transport|,glucose transmembrane transporter activity|hexose transmembrane transporter activity|dehydroascorbic acid transporter activity|D-glucose transmembrane transporter activity|,1,4.2,4.89,0,0,0,4.2,4.72,0.0827,1,9
ENSMUSG00000032463,FAIM,Fas apoptotic inhibitory molecule,cytoplasm|,apoptotic process|negative regulation of apoptotic process|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|,None,10,-1.9,0.626,10,-3.9,5.5,-2.8,4.72,0.0827,-7.8,0
ENSMUSG00000029291,RUFY3,RUN and FYVE domain containing 3,filopodium|growth cone|,negative regulation of axonogenesis|,None,1,4.2,4.89,0,0,0,4.2,4.72,0.0827,1,9
ENSMUSG00000037740,MRPS26,mitochondrial ribosomal protein S26,nucleus|mitochondrion|mitochondrial small ribosomal subunit|,"DNA damage response, detection of DNA damage|peptide biosynthetic process|",poly(A) RNA binding|,9,-4.6,2.48,10,-2,3.49,-2.5,4.72,0.0827,-8.2,1.6
ENSMUSG00000030177,CCDC77,coiled-coil domain containing 77,centrosome|membrane|,None,None,1,4.1,4.88,0,0,0,4.1,4.71,0.0831,1,9
ENSMUSG00000028801,STPG1,sperm-tail PG-rich repeat containing 1,nucleus|cytoplasm|,apoptotic process|,None,1,4.8,4.88,0,0,0,4.8,4.71,0.0831,1.3,10
ENSMUSG00000022089,BIN3,bridging integrator 3,cytoplasm|cytoskeleton|,cytokinesis|barrier septum assembly|actin filament organization|protein localization|unidimensional cell growth|,protein binding|cytoskeletal adaptor activity|,9,-0.1,0.00592,10,-2.4,5.46,-2.4,4.71,0.0831,-6.7,1
ENSMUSG00000036053,FMNL2,formin-like 2,cytoplasm|,cytoskeleton organization|regulation of cell morphogenesis|cortical actin cytoskeleton organization|,actin binding|Rho GTPase binding|,1,4.3,4.87,0,0,0,4.3,4.7,0.0833,1,9
ENSMUSG00000051276,ACTRT2,actin-related protein T2,cytoplasm|cytoskeleton|,None,None,1,4.1,4.88,0,0,0,4.1,4.7,0.0833,1,9
ENSMUSG00000073724,PRAMEL4,preferentially expressed antigen in melanoma like 4,cellular_component|,biological_process|,molecular_function|,1,4.1,4.87,0,0,0,4.1,4.7,0.0833,1,9
ENSMUSG00000073723,GM13102,predicted gene 13102,cellular_component|,biological_process|,molecular_function|,1,4.1,4.87,0,0,0,4.1,4.7,0.0833,1,9
ENSMUSG00000024947,MEN1,multiple endocrine neoplasia I,chromatin|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear matrix|cleavage furrow|histone methyltransferase complex|histone methyltransferase complex|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|leukocyte homeostasis|negative regulation of protein phosphorylation|osteoblast fate commitment|osteoblast development|DNA repair|chromatin remodeling|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|cellular response to DNA damage stimulus|cell cycle arrest|transforming growth factor beta receptor signaling pathway|brain development|negative regulation of cell proliferation|response to UV|response to gamma radiation|gene expression|hemopoiesis|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of histone methylation|positive regulation of protein binding|regulation of activin receptor signaling pathway|histone lysine methylation|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of osteoblast differentiation|positive regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of JNK cascade|negative regulation of organ growth|embryonic skeletal system morphogenesis|positive regulation of cell division|negative regulation of telomerase activity|palate development|maternal process involved in female pregnancy|","four-way junction DNA binding|Y-form DNA binding|chromatin binding|double-stranded DNA binding|protein binding|histone-lysine N-methyltransferase activity|protein binding, bridging|sequence-specific DNA binding|transcription regulatory region DNA binding|protein N-terminus binding|R-SMAD binding|",10,-2.7,4.27,10,-1.2,1.34,-2.3,4.7,0.0833,-5.7,1.3
ENSMUSG00000021635,RAD17,RAD17 homolog (S. pombe),"chromosome, telomeric region|nucleus|nucleoplasm|",DNA replication checkpoint|DNA damage checkpoint|DNA replication|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation|,protein binding|ATP binding|nucleoside-triphosphatase activity|,6,-5.9,3.65,7,-1.8,2.97,-3.7,4.69,0.0837,-10.7,0.6
ENSMUSG00000036634,MAG,myelin associated glycoprotein,plasma membrane|integral component of membrane|paranode region of axon|Schmidt-Lanterman incisure|,cell adhesion|blood coagulation|substantia nigra development|neurotrophin TRK receptor signaling pathway|regulation of axonogenesis|negative regulation of axonogenesis|leukocyte migration|,None,1,4.3,4.86,0,0,0,4.3,4.69,0.0837,1,9
ENSMUSG00000070385,AMPD1,adenosine monophosphate deaminase 1,cytosol|,purine nucleobase metabolic process|response to organic substance|IMP salvage|purine-containing compound salvage|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,AMP deaminase activity|myosin heavy chain binding|metal ion binding|,9,2.4,3.67,10,-3.2,5.06,-3.2,4.69,0.0837,-8.3,5.1
ENSMUSG00000021236,ENTPD5,ectonucleoside triphosphate diphosphohydrolase 5,endoplasmic reticulum|extracellular vesicular exosome|,glycolytic process|protein N-linked glycosylation|cell proliferation|regulation of phosphatidylinositol 3-kinase signaling|cell growth|positive regulation of glycolytic process|ATP metabolic process|'de novo' posttranslational protein folding|,guanosine-diphosphatase activity|uridine-diphosphatase activity|,10,-1.5,2.65,10,-1.3,2.35,-1.4,4.69,0.0837,-4.3,0.2
ENSMUSG00000062844,OLFR1458,olfactory receptor 1458,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-0.5,0.0861,1,5.1,5.44,5.1,4.69,0.0837,1.1,10
ENSMUSG00000028622,MRPL37,mitochondrial ribosomal protein L37,mitochondrion|mitochondrial ribosome|,translation|,structural constituent of ribosome|poly(A) RNA binding|,1,4.8,4.86,0,0,0,4.8,4.69,0.0837,1.3,10
ENSMUSG00000038855,ITPKB,inositol-trisphosphate 3-kinase B,cytosol|,MAPK cascade|signal transduction|cell surface receptor signaling pathway|inositol phosphate metabolic process|small molecule metabolic process|positive thymic T cell selection|positive regulation of Ras protein signal transduction|positive regulation of alpha-beta T cell differentiation|,"protein binding|calmodulin binding|ATP binding|inositol-1,4,5-trisphosphate 3-kinase activity|",0,0,0,1,4.8,4.85,4.8,4.68,0.0839,1.3,10
ENSMUSG00000026914,PSMD14,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 14","proteasome complex|nucleus|nucleoplasm|cytosol|proteasome regulatory particle, lid subcomplex|proteasome accessory complex|extracellular vesicular exosome|","G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|double-strand break repair via homologous recombination|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|positive regulation of endopeptidase activity|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of proteasomal protein catabolic process|protein K63-linked deubiquitination|protein K63-linked deubiquitination|",ubiquitin thiolesterase activity|ubiquitin thiolesterase activity|metallopeptidase activity|metal ion binding|endopeptidase activator activity|proteasome binding|,8,3.8,5.64,8,1.2,0.802,3.6,4.68,0.0839,-3.8,8.4
ENSMUSG00000041020,MAP7D2,MAP7 domain containing 2,microtubule|,microtubule cytoskeleton organization|,None,10,-3.6,6.59,10,-0.5,0.128,-3.3,4.67,0.0842,-7.5,0.2
ENSMUSG00000030402,PPM1N,"protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)",None,dephosphorylation|,magnesium ion binding|phosphoprotein phosphatase activity|manganese ion binding|,1,4.1,4.84,0,0,0,4.1,4.67,0.0842,1,9
ENSMUSG00000027087,ITGAV,"integrin, alpha V",plasma membrane|plasma membrane|integral component of plasma membrane|integrin complex|integrin complex|external side of plasma membrane|cell surface|cell surface|membrane|alphav-beta3 integrin-IGF-1-IGF1R complex|phagocytic vesicle|extracellular vesicular exosome|,"angiogenesis|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|axon guidance|blood coagulation|positive regulation of cell proliferation|response to virus|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|extracellular matrix organization|positive regulation of cell migration|cell-substrate adhesion|negative regulation of lipid transport|positive regulation of osteoblast proliferation|antigen processing and presentation of exogenous peptide antigen via MHC class I|apoptotic cell clearance|negative regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of cell adhesion|viral entry into host cell|negative regulation of lipoprotein metabolic process|regulation of phagocytosis|leukocyte migration|entry of symbiont into host cell by promotion of host phagocytosis|ERK1 and ERK2 cascade|calcium ion transmembrane transport|extrinsic apoptotic signaling pathway in absence of ligand|regulation of apoptotic cell clearance|negative regulation of entry of bacterium into host cell|negative regulation of extrinsic apoptotic signaling pathway|",virus receptor activity|opsonin binding|protein kinase C binding|voltage-gated calcium channel activity|protein binding|insulin-like growth factor I binding|metal ion binding|transforming growth factor beta binding|,10,3.3,6.71,10,-2.9,5.33,-2.8,4.67,0.0842,-9.3,7.3
ENSMUSG00000034165,CCND3,cyclin D3,cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|membrane|,positive regulation of protein phosphorylation|cell cycle|signal transduction|T cell proliferation|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|,cyclin-dependent protein serine/threonine kinase activity|protein binding|protein kinase binding|,10,0,0,10,-2.6,5.61,-2.6,4.66,0.0847,-6.4,0.4
ENSMUSG00000022960,DONSON,downstream neighbor of SON,cellular_component|nucleus|,multicellular organismal development|biological_process|,molecular_function|,1,4,4.83,0,0,0,4,4.66,0.0847,0.9,9
ENSMUSG00000028549,ITGB3BP,integrin beta 3 binding protein (beta3-endonexin),condensed chromosome kinetochore|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|,"mitotic cell cycle|nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|mitotic nuclear division|cell adhesion|signal transduction|centromere-specific nucleosome assembly|positive regulation of apoptotic process|neurotrophin TRK receptor signaling pathway|apoptotic signaling pathway|",signal transducer activity|protein C-terminus binding|,8,-5.7,4.74,7,-1.5,3.19,-3.6,4.66,0.0847,-10.2,0
ENSMUSG00000038510,RPF2,ribosome production factor 2 homolog (S. cerevisiae),nucleolus|,None,poly(A) RNA binding|,1,4,4.84,0,0,0,4,4.66,0.0847,1,9
ENSMUSG00000058355,ABCE1,"ATP-binding cassette, sub-family E (OABP), member 1",cytoplasm|mitochondrion|membrane|,ATP catabolic process|RNA catabolic process|response to virus|viral process|negative regulation of catalytic activity|,ATP binding|ribonuclease inhibitor activity|ATPase activity|iron-sulfur cluster binding|,4,3.1,4.12,2,2.2,0.963,2.5,4.65,0.0852,-2.8,7
ENSMUSG00000037151,LRRC20,leucine rich repeat containing 20,None,None,None,1,4,4.81,0,0,0,4,4.64,0.0856,0.9,9
ENSMUSG00000019906,LIN7A,lin-7 homolog A (C. elegans),tight junction|postsynaptic density|basolateral plasma membrane|neuron projection|postsynaptic membrane|extracellular vesicular exosome|,protein complex assembly|exocytosis|neurotransmitter secretion|protein transport|synaptic vesicle transport|inner ear development|,protein binding|PDZ domain binding|L27 domain binding|,1,4.5,4.8,0,0,0,4.5,4.62,0.0864,1.2,10
ENSMUSG00000059383,GFRAL,GDNF family receptor alpha like,plasma membrane|integral component of membrane|,stress-activated protein kinase signaling cascade|negative regulation of neuron apoptotic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,None,9,-4.6,6.49,10,0.2,0.057,-3.6,4.62,0.0864,-11,9
ENSMUSG00000022415,SYNGR1,synaptogyrin 1,integral component of membrane|integral component of membrane|cell junction|synaptic vesicle membrane|melanosome|,protein targeting|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|,None,1,4.5,4.79,0,0,0,4.5,4.62,0.0864,1.2,10
ENSMUSG00000030827,FGF21,fibroblast growth factor 21,extracellular region|,signal transduction|cell-cell signaling|positive regulation of cell proliferation|regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of glucose import|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|,fibroblast growth factor receptor binding|protein binding|growth factor activity|,0,0,0,1,4.8,4.79,4.8,4.62,0.0864,1.2,10
ENSMUSG00000062078,QK,quaking,nucleus|cytoplasm|,vasculogenesis|mRNA processing|regulation of translation|transport|multicellular organismal development|spermatid development|axon ensheathment|RNA splicing|positive regulation of gene expression|cell differentiation|myelination|muscle cell differentiation|long-chain fatty acid biosynthetic process|mRNA transport|3'-UTR-mediated mRNA destabilization|,RNA binding|mRNA binding|SH3 domain binding|poly(A) RNA binding|,9,1.7,1.43,10,4.8,5.44,4.6,4.61,0.0867,-1.8,9.4
ENSMUSG00000058126,TPM3-RS7,"tropomyosin 3, related sequence 7",None,None,None,1,4.6,4.78,0,0,0,4.6,4.61,0.0867,1.2,10
ENSMUSG00000038628,POLR3K,"polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa",nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|,transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|innate immune response|defense response to virus|,RNA polymerase III activity|DNA binding|DNA-directed RNA polymerase activity|zinc ion binding|,7,4.4,4.5,7,-1,1.41,-2.1,4.61,0.0867,-7.6,7.1
ENSMUSG00000021103,MNAT1,MNAT CDK-activating kinase assembly factor 1,nucleus|nucleoplasm|holo TFIIH complex|cytoplasm|,"regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage removal|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein complex assembly|protein phosphorylation|adult heart development|cell proliferation|gene expression|viral process|ventricular system development|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of smooth muscle cell proliferation|positive regulation of viral transcription|response to calcium ion|",protein binding|DNA-dependent ATPase activity|zinc ion binding|RNA polymerase II carboxy-terminal domain kinase activity|protein N-terminus binding|,7,7.5,5.64,8,-1.5,1.63,7.3,4.6,0.087,-3.2,16
ENSMUSG00000026315,SERPINB8,"serpin peptidase inhibitor, clade B (ovalbumin), member 8",extracellular space|cytosol|,negative regulation of endopeptidase activity|regulation of proteolysis|,serine-type endopeptidase inhibitor activity|protein binding|,0,0,0,1,4.8,4.77,4.8,4.59,0.0874,0.9,9
ENSMUSG00000031897,PSMB10,"proteasome (prosome, macropain) subunit, beta type, 10",proteasome complex|nucleoplasm|cytosol|proteasome core complex|spermatoproteasome complex|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|cell morphogenesis|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|humoral immune response|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|T cell proliferation|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",threonine-type endopeptidase activity|,0,0,0,1,4.8,4.77,4.8,4.59,0.0874,0.9,9
ENSMUSG00000043241,UPF2,UPF2 regulator of nonsense transcripts homolog (yeast),nucleus|cytoplasm|cytosol|exon-exon junction complex|perinuclear region of cytoplasm|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|liver development|mRNA export from nucleus|gene expression|RNA metabolic process|mRNA metabolic process|organ regeneration|",RNA binding|protein binding|,10,6.5,3.18,10,-3.4,3.38,-2.7,4.58,0.0878,-9.7,9.2
ENSMUSG00000022678,NDE1,nudE neurodevelopment protein 1,kinetochore|condensed chromosome kinetochore|centrosome|cytosol|microtubule|membrane|spindle pole centrosome|cleavage furrow|,G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|mitotic cell cycle|neuron migration|microtubule nucleation|mitotic nuclear division|neuroblast proliferation|cerebral cortex development|vesicle transport along microtubule|centrosome duplication|establishment of chromosome localization|,protein binding|microtubule binding|protein domain specific binding|identical protein binding|,8,-1.9,0.972,9,-2.9,4.33,-2.3,4.57,0.0882,-7,2.2
ENSMUSG00000029434,VPS33A,vacuolar protein sorting 33 homolog A (S. cerevisiae),lysosomal membrane|early endosome|late endosome|HOPS complex|late endosome membrane|perinuclear region of cytoplasm|,vesicle docking involved in exocytosis|protein transport|vesicle-mediated transport|platelet formation|melanosome localization|lysosome localization|regulation of developmental pigmentation|,protein binding|,0,0,0,1,4.7,4.74,4.7,4.57,0.0882,0.9,9
ENSMUSG00000067702,TUBA3A,"tubulin, alpha 3A",nucleus|microtubule|cilium|ciliary basal body|,None,None,10,0.4,0.107,10,-5.9,5.62,-4.4,4.57,0.0882,-11.4,-0.2
ENSMUSG00000017428,PSMD11,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 11",proteasome complex|nucleus|nucleoplasm|cytosol|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|proteasome assembly|small molecule metabolic process|stem cell differentiation|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|,5,-3.6,2.5,4,-2.4,2.52,-3.3,4.56,0.0887,-8,0.9
ENSMUSG00000091964,BC037034,cDNA sequence BC037034,cellular_component|,biological_process|,molecular_function|,10,-5.5,2.98,10,-3.4,2.56,-3.5,4.55,0.089,-9.5,1
ENSMUSG00000019841,REV3L,"REV3-like, polymerase (DNA directed), zeta, catalytic subunit",nucleus|chromosome|zeta DNA polymerase complex|,DNA-dependent DNA replication|translesion synthesis|,"nucleotide binding|DNA binding|DNA-directed DNA polymerase activity|protein binding|metal ion binding|4 iron, 4 sulfur cluster binding|",10,0.8,0.399,10,-3.2,6.64,-3,4.54,0.0895,-7.6,2.8
ENSMUSG00000002489,TIAM1,T-cell lymphoma invasion and metastasis 1,cytosol|cell-cell junction|extrinsic component of cytoplasmic side of plasma membrane|cell-cell contact zone|,cell-matrix adhesion|small GTPase mediated signal transduction|cell migration|Rac protein signal transduction|positive regulation of Rho GTPase activity|positive regulation of Rac GTPase activity|positive regulation of apoptotic process|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity|phospholipid binding|Rac guanyl-nucleotide exchange factor activity|ephrin receptor binding|,10,-1.5,1.43,10,-1.8,3.43,-1.6,4.54,0.0895,-6,3
ENSMUSG00000034557,ZFYVE9,"zinc finger, FYVE domain containing 9",early endosome|early endosome membrane|early endosome membrane|,proteolysis|endocytosis|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|SMAD protein import into nucleus|negative regulation of transforming growth factor beta receptor signaling pathway|,protein binding|1-phosphatidylinositol binding|serine-type peptidase activity|metal ion binding|,10,5.7,4.26,10,-2.5,5.19,-2.2,4.54,0.0895,-7.7,9.8
ENSMUSG00000027285,HAUS2,"HAUS augmin-like complex, subunit 2",nucleus|cytoplasm|Golgi apparatus|centrosome|spindle|cytosol|microtubule|HAUS complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|spindle assembly|centrosome organization|,molecular_function|,8,3.3,0.843,8,2.7,4.04,2.8,4.54,0.0895,-3,8
ENSMUSG00000024833,POLA2,"polymerase (DNA directed), alpha 2, accessory subunit",nucleus|nucleoplasm|alpha DNA polymerase:primase complex|cytoplasm|,"protein import into nucleus, translocation|G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA replication initiation|DNA replication initiation|DNA strand elongation involved in DNA replication|telomere maintenance via semi-conservative replication|",molecular_function|DNA binding|DNA-directed DNA polymerase activity|protein heterodimerization activity|,10,-5.4,4.47,10,3.4,7.42,3.1,4.53,0.09,-7.6,7.3
ENSMUSG00000029553,TFEC,transcription factor EC,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to heat|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein dimerization activity|,9,-0.8,0.748,10,6,6.98,5.5,4.53,0.09,0.2,12.4
ENSMUSG00000041523,UPK2,uroplakin 2,integral component of plasma membrane|apical plasma membrane|integral component of endoplasmic reticulum membrane|extracellular vesicular exosome|,multicellular organismal development|epithelial cell differentiation|membrane organization|,None,10,-0.1,0.00799,10,-6.1,7.08,-4.9,4.52,0.0905,-11.4,-0.4
ENSMUSG00000029463,FAM216A,"family with sequence similarity 216, member A",None,None,None,0,0,0,1,4.7,4.69,4.7,4.52,0.0905,0.8,9
ENSMUSG00000059586,NSMCE2,"non-SMC element 2, MMS21 homolog (S. cerevisiae)","chromosome, telomeric region|nucleus|PML body|Smc5-Smc6 complex|",telomere maintenance via recombination|double-strand break repair via homologous recombination|mitotic nuclear division|protein sumoylation|positive regulation of maintenance of mitotic sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|cellular senescence|,protein binding|zinc ion binding|SUMO ligase activity|,9,2.5,2.41,10,-2.3,5,-3.2,4.52,0.0905,-7.7,4.9
ENSMUSG00000038542,PCID2,PCI domain containing 2,cellular_component|,"negative regulation of apoptotic process|regulation of mRNA stability|positive regulation of B cell differentiation|positive regulation of transcription, DNA-templated|spleen development|positive regulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of cysteine-type endopeptidase activity|",None,4,-3.7,4.71,6,4.3,2.02,-3.5,4.52,0.0905,-8,6.7
ENSMUSG00000004980,HNRNPA2B1,heterogeneous nuclear ribonucleoprotein A2/B1,nucleus|nucleoplasm|spliceosomal complex|cytoplasm|membrane|ribonucleoprotein complex|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA processing|RNA splicing|gene expression|negative regulation of mRNA splicing, via spliceosome|RNA transport|",nucleotide binding|RNA binding|protein binding|single-stranded telomeric DNA binding|poly(A) RNA binding|pre-mRNA intronic binding|,10,-1.9,1.4,10,-5.9,4.8,-1.6,4.51,0.0908,-11,0
ENSMUSG00000041859,MCM3,minichromosome maintenance complex component 3,nucleus|nucleoplasm|alpha DNA polymerase:primase complex|centrosome|membrane|MCM complex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA duplex unwinding|,DNA binding|DNA helicase activity|protein binding|ATP binding|,6,-4.3,3.38,5,-2.6,1.68,-4,4.51,0.0908,-9.5,3.4
ENSMUSG00000024155,MEIOB,meiosis specific with OB domains,nucleus|chromosome|cytoplasm|,"resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|DNA catabolic process, exonucleolytic|synapsis|male meiosis|female meiosis I|fertilization|",chromatin binding|single-stranded DNA binding|single-stranded DNA 3'-5' exodeoxyribonuclease activity|,0,0,0,1,4.7,4.67,4.7,4.5,0.0913,0.8,9
ENSMUSG00000021448,SHC3,SHC (Src homology 2 domain containing) transforming protein 3,cellular_component|cytosol|,"transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|central nervous system development|learning or memory|insulin receptor signaling pathway|synaptic transmission, glutamatergic|neurotrophin TRK receptor signaling pathway|",signal transducer activity|protein binding|,0,0,0,1,4.7,4.67,4.7,4.5,0.0913,0.8,9
ENSMUSG00000039128,CDC123,cell division cycle 123,cytoplasm|,cell cycle arrest|regulation of mitotic cell cycle|positive regulation of cell proliferation|cell division|,None,7,-3.4,4.58,7,5.7,2.89,-3.3,4.49,0.0917,-8,8
ENSMUSG00000025001,HELLS,"helicase, lymphoid-specific","chromosome, centromeric region|nucleus|centromeric heterochromatin|","urogenital system development|methylation-dependent chromatin silencing|transcription, DNA-templated|mitotic nuclear division|multicellular organismal development|maintenance of DNA methylation|centromeric heterochromatin assembly|negative regulation of apoptotic process|lymphocyte proliferation|negative regulation of intrinsic apoptotic signaling pathway|",DNA binding|chromatin binding|helicase activity|protein binding|ATP binding|,9,-2.6,3.85,9,2.4,4.98,2.5,4.49,0.0917,-5.4,6.2
ENSMUSG00000020166,CNOT2,"CCR4-NOT transcription complex, subunit 2",nucleus|cytoplasm|cytosol|membrane|CCR4-NOT complex|,"negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|trophectodermal cell differentiation|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of translation|gene expression|positive regulation of cytoplasmic mRNA processing body assembly|RNA metabolic process|mRNA metabolic process|gene silencing by RNA|negative regulation of intracellular estrogen receptor signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of stem cell maintenance|",RNA polymerase II transcription cofactor activity|RNA polymerase II transcription corepressor binding|poly(A)-specific ribonuclease activity|protein binding|,10,-3.6,5.21,9,3.1,2.3,-3.2,4.48,0.0919,-7.6,4.3
ENSMUSG00000040584,ABCB1A,"ATP-binding cassette, sub-family B (MDR/TAP), member 1A",plasma membrane|cell surface|membrane|integral component of membrane|apical part of cell|intercellular canaliculus|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|ATP catabolic process|transport|drug transmembrane transport|hormone transport|drug transport|daunorubicin transport|drug export|transmembrane transport|negative regulation of cell death|establishment of blood-brain barrier|stem cell proliferation|positive regulation of response to drug|,"nucleotide binding|ATP binding|xenobiotic-transporting ATPase activity|hydrolase activity|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to transmembrane movement of substances|",10,-2,1.62,10,2.1,4.43,1.8,4.47,0.0924,-3.2,4.9
ENSMUSG00000043535,SETX,senataxin,nucleus|nucleoplasm|nucleolus|cytoplasm|,double-strand break repair|termination of RNA polymerase II transcription|RNA processing|circadian rhythm|cell death|DNA duplex unwinding|,DNA binding|DNA helicase activity|ATP binding|,10,-1.9,3.77,10,-0.9,1.28,-1.7,4.47,0.0924,-4,0.1
ENSMUSG00000051615,RAP2A,"RAP2A, member of RAS oncogene family",cytosol|midbody|recycling endosome|recycling endosome membrane|extracellular vesicular exosome|,GTP catabolic process|negative regulation of cell migration|actin cytoskeleton reorganization|positive regulation of protein autophosphorylation|Rap protein signal transduction|cellular protein localization|establishment of protein localization|regulation of JNK cascade|regulation of dendrite morphogenesis|,GTPase activity|protein binding|GTP binding|,10,-3.2,4.5,9,-0.8,1.07,-3,4.47,0.0924,-6.3,0.8
ENSMUSG00000024422,DHX16,DEAH (Asp-Glu-Ala-His) box polypeptide 16,nucleus|,ATP catabolic process|mRNA processing|RNA splicing|,RNA helicase activity|protein binding|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,9,-3,3.15,8,-1.7,2.11,-2.7,4.46,0.0929,-8.3,0.9
ENSMUSG00000006782,CNP,"2',3'-cyclic nucleotide 3' phosphodiesterase",extracellular space|nucleus|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|microtubule|plasma membrane|microvillus|membrane|pseudopodium|myelin sheath abaxonal region|myelin sheath adaxonal region|melanosome|perinuclear region of cytoplasm|extracellular vesicular exosome|,microtubule cytoskeleton organization|synaptic transmission|axonogenesis|aging|adult locomotory behavior|cyclic nucleotide catabolic process|response to toxic substance|substantia nigra development|response to lipopolysaccharide|regulation of mitochondrial membrane permeability|,"RNA binding|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|cyclic nucleotide binding|",9,-4.9,6.76,9,-0.5,0.263,-4.8,4.46,0.0929,-9.5,0.1
ENSMUSG00000031561,TENM3,teneurin transmembrane protein 3,membrane|integral component of membrane|axon|,homophilic cell adhesion|signal transduction|positive regulation of neuron projection development|camera-type eye morphogenesis|,protein homodimerization activity|protein heterodimerization activity|,10,-1.6,3.71,10,2.6,2.65,-1.5,4.45,0.0932,-11.1,4.6
ENSMUSG00000024256,ADCYAP1,adenylate cyclase activating polypeptide 1 (pituitary),extracellular region|extracellular space|terminal bouton|,"ovarian follicle development|behavioral fear response|histamine secretion|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of acute inflammatory response to non-antigenic stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|cell-cell signaling|female pregnancy|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|negative regulation of muscle cell apoptotic process|positive regulation of neuron projection development|sensory perception of pain|cAMP-mediated signaling|pituitary gland development|neuron projection development|positive regulation of interleukin-6 production|positive regulation of Rap GTPase activity|regulation of protein localization|negative regulation of Rho GTPase activity|response to starvation|negative regulation of potassium ion transport|response to ethanol|negative regulation of cell cycle|positive regulation of protein kinase activity|positive regulation of vasodilation|positive regulation of transcription from RNA polymerase II promoter|ATP metabolic process|neurotrophin TRK receptor signaling pathway|positive regulation of synaptic transmission, glutamatergic|regulation of postsynaptic membrane potential|positive regulation of growth hormone secretion|negative regulation of glial cell proliferation|positive regulation of ERK1 and ERK2 cascade|regulation of oligodendrocyte progenitor proliferation|cellular response to glucocorticoid stimulus|positive regulation of somatostatin secretion|",receptor signaling protein activity|receptor binding|neuropeptide hormone activity|pituitary adenylate cyclase activating polypeptide activity|pituitary adenylate cyclase-activating polypeptide receptor binding|peptide hormone receptor binding|peptide hormone receptor binding|,10,-0.7,0.79,10,-1.6,4.38,-1.4,4.45,0.0932,-5.1,2.3
ENSMUSG00000030493,C230052I12RIK,RIKEN cDNA C230052I12 gene,nucleus|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex|,DNA repair|cellular response to DNA damage stimulus|biological_process|,DNA binding|chromatin binding|,10,-3.3,1.91,10,-4,2.85,-3.5,4.45,0.0932,-8.9,1.2
ENSMUSG00000032265,FAM46A,"family with sequence similarity 46, member A",None,regulation of gene expression|regulation of blood coagulation|,poly(A) RNA binding|,1,3.9,4.62,0,0,0,3.9,4.45,0.0932,0.5,8
ENSMUSG00000025316,BANP,BTG3 associated nuclear protein,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|multicellular organismal development|chromatin modification|protein localization to nucleus|negative regulation of protein catabolic process|",p53 binding|DNA binding|protein binding|,8,2.9,4.01,7,1.6,1.3,2.4,4.45,0.0932,-1.9,8.2
ENSMUSG00000031751,AMFR,"autocrine motility factor receptor, E3 ubiquitin protein ligase",Hrd1p ubiquitin ligase complex|nucleus|endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|dendrite|growth cone|neuronal cell body|protein complex|perinuclear region of cytoplasm|,protein polyubiquitination|ubiquitin-dependent protein catabolic process|cellular component movement|signal transduction|aging|learning or memory|ER-associated ubiquitin-dependent protein catabolic process|ER-associated ubiquitin-dependent protein catabolic process|endoplasmic reticulum unfolded protein response|protein oligomerization|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|receptor activity|protein binding|zinc ion binding|ligase activity|,10,-7,6.87,10,-0.8,0.53,-1.7,4.44,0.0936,-12.3,-0.1
ENSMUSG00000048332,LHFP,lipoma HMGIC fusion partner,integral component of membrane|,None,DNA binding|,10,2,3.53,10,-5.9,6.45,-1.4,4.43,0.0941,-12,1.9
ENSMUSG00000021374,NUP153,nucleoporin 153kDa,nuclear pore|nucleoplasm|nucleolus|cytoplasm|nuclear membrane|nuclear periphery|nuclear inclusion body|nuclear pore nuclear basket|,mitotic cell cycle|carbohydrate metabolic process|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|viral entry into host cell|negative regulation of RNA export from nucleus|mRNA transport|nuclear pore complex assembly|transmembrane transport|viral penetration into host nucleus|,DNA binding|transporter activity|nucleocytoplasmic transporter activity|protein binding|zinc ion binding|structural constituent of nuclear pore|identical protein binding|protein anchor|,9,-3.1,3.88,9,-1.6,1.28,-2,4.42,0.0944,-9.4,1.2
ENSMUSG00000078817,NLRP12,"NLR family, pyrin domain containing 12",cytoplasm|,activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|release of cytoplasmic sequestered NF-kappaB|negative regulation of signal transduction|negative regulation of protein autophosphorylation|negative regulation of NF-kappaB transcription factor activity|dendritic cell migration|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MHC class I biosynthetic process|regulation of interleukin-18 biosynthetic process|negative regulation of interleukin-6 biosynthetic process|negative regulation of Toll signaling pathway|negative regulation of cytokine secretion|negative regulation of interleukin-1 secretion|positive regulation of interleukin-1 beta secretion|negative regulation of inflammatory response|positive regulation of inflammatory response|negative regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|negative regulation of NIK/NF-kappaB signaling|,protein binding|ATP binding|cysteine-type endopeptidase activator activity involved in apoptotic process|,10,2.1,3.82,9,1.2,1.02,1.8,4.41,0.0948,-1.3,5.2
ENSMUSG00000030744,RPS3,ribosomal protein S3,nucleus|nucleus|cytoplasm|cytosol|cytosol|membrane|cytosolic small ribosomal subunit|ribonucleoprotein complex|ruffle membrane|extracellular vesicular exosome|NF-kappaB complex|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA catabolic process, endonucleolytic|cytoplasmic translation|translation|translation|translation|translational initiation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|cellular response to DNA damage stimulus|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|cellular protein metabolic process|negative regulation of DNA repair|positive regulation of NF-kappaB transcription factor activity|nucleic acid phosphodiester bond hydrolysis|positive regulation of DNA N-glycosylase activity|positive regulation of apoptotic signaling pathway|",damaged DNA binding|mRNA binding|structural constituent of ribosome|structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|protein binding|enzyme binding|protein kinase binding|poly(A) RNA binding|protein kinase A binding|NF-kappaB binding|iron-sulfur cluster binding|,4,-4.7,3.56,4,-1.8,2.1,-4.4,4.41,0.0948,-10,0.8
ENSMUSG00000069917,HBA-A2,"hemoglobin alpha, adult chain 2",hemoglobin complex|membrane|cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|extracellular vesicular exosome|blood microparticle|,in utero embryonic development|erythrocyte development|,peroxidase activity|haptoglobin binding|,9,-2.6,5.85,9,1.6,1.6,-2.3,4.41,0.0948,-6.1,2.8
ENSMUSG00000034602,MON2,MON2 homolog (S. cerevisiae),trans-Golgi network|,Golgi to endosome transport|protein transport|vesicle-mediated transport|actin cytoskeleton organization|positive regulation of GTPase activity|,ARF guanyl-nucleotide exchange factor activity|protein binding|,0,0,0,1,4.5,4.58,4.5,4.41,0.0948,0.8,9
ENSMUSG00000023961,ENPP4,ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative),plasma membrane|membrane|integral component of membrane|extracellular vesicular exosome|,blood coagulation|positive regulation of blood coagulation|purine ribonucleoside catabolic process|,metal ion binding|bis(5'-adenosyl)-triphosphatase activity|,9,1.2,1.34,10,-2.6,6.55,-2.5,4.38,0.0961,-6.3,1.5
ENSMUSG00000030516,TJP1,tight junction protein 1,nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|cell-cell adherens junction|gap junction|tight junction|intercalated disc|basolateral plasma membrane|apical plasma membrane|apicolateral plasma membrane|cell junction|apical junction complex|apical part of cell|intercellular canaliculus|,blastocyst formation|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|cell-cell junction assembly|response to lipopolysaccharide|hippo signaling|response to drug|negative regulation of vascular permeability|response to ethanol|membrane organization|response to magnetism|cellular response to glucose stimulus|cell-cell signaling involved in cell-cell junction organization|,protein binding|calmodulin binding|protein C-terminus binding|protein domain specific binding|,10,-4,3.63,10,-2.9,1.14,-3.9,4.38,0.0961,-9.5,0.8
ENSMUSG00000038793,LEFTY1,left-right determination factor 1,extracellular space|,negative regulation of transcription from RNA polymerase II promoter|heart morphogenesis|transforming growth factor beta receptor signaling pathway|determination of left/right symmetry|cell growth|,cytokine activity|transforming growth factor beta receptor binding|growth factor activity|,0,0,0,1,4.4,4.55,4.4,4.38,0.0961,0.7,9
ENSMUSG00000071662,POLR2G,polymerase (RNA) II (DNA directed) polypeptide G,"cytoplasmic mRNA processing body|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|nucleolus|","nuclear-transcribed mRNA catabolic process, exonucleolytic|mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|RNA splicing|gene expression|viral process|positive regulation of translational initiation|positive regulation of viral transcription|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|",single-stranded DNA binding|single-stranded RNA binding|DNA-directed RNA polymerase activity|translation initiation factor binding|,3,-1.3,0.414,6,-2.2,4.38,-2,4.37,0.0965,-7.7,0.2
ENSMUSG00000046768,RHOJ,ras homolog family member J,cellular_component|cytosol|plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|Rho protein signal transduction|regulation of cell shape|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction|retina vasculature morphogenesis in camera-type eye|,GTPase activity|GTP binding|,10,-6.1,6.35,10,0,0,-6,4.37,0.0965,-11.5,0.7
ENSMUSG00000044674,FZD1,frizzled class receptor 1,cytoplasm|plasma membrane|cell surface|integral component of membrane|neuron projection membrane|apical part of cell|,"positive regulation of protein phosphorylation|vasculature development|membranous septum morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|Wnt signaling pathway, calcium modulating pathway|cell-cell signaling|axonogenesis|brain development|gonad development|neuron differentiation|negative regulation of BMP signaling pathway|epithelial cell differentiation|negative regulation of catenin import into nucleus|autocrine signaling|response to drug|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|lung alveolus development|positive regulation of sequence-specific DNA binding transcription factor activity|hard palate development|canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|",G-protein coupled receptor activity|receptor binding|frizzled binding|protein binding|Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|,10,-3.5,2.91,10,-2,2.08,-3.2,4.37,0.0965,-9.2,2.4
ENSMUSG00000078762,HAUS5,"HAUS augmin-like complex, subunit 5",cytoplasm|centrosome|spindle|microtubule|HAUS complex|,mitotic nuclear division|spindle assembly|centrosome organization|,molecular_function|,8,6.2,4.59,7,3.4,1.46,6,4.37,0.0965,-5.9,14
ENSMUSG00000020923,UBTF,"upstream binding transcription factor, RNA polymerase I",nucleoplasm|nucleolus|nucleolus|,chromatin silencing at rDNA|regulation of transcription from RNA polymerase I promoter|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|gene expression|positive regulation of transcription from RNA polymerase I promoter|,DNA binding|protein binding|poly(A) RNA binding|,6,-3.5,5.92,6,3.7,3.22,4,4.36,0.097,-5.4,10
ENSMUSG00000029369,AFM,afamin,extracellular region|extracellular space|extracellular vesicular exosome|blood microparticle|,vitamin transport|,vitamin E binding|,1,3.8,4.53,0,0,0,3.8,4.36,0.097,0.5,8
ENSMUSG00000002210,SMG9,SMG9 nonsense mediated mRNA decay factor,intracellular|cytosol|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|gene expression|RNA metabolic process|mRNA metabolic process|",protein binding|identical protein binding|,9,-2,2.16,10,-1.5,2.52,-1.9,4.36,0.097,-5.7,3.4
ENSMUSG00000030589,RASGRP4,RAS guanyl releasing protein 4,cytoplasm|plasma membrane|membrane|,transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|small GTPase mediated signal transduction|regulation of G-protein coupled receptor protein signaling pathway|cell proliferation|response to extracellular stimulus|cell growth|myeloid cell differentiation|positive regulation of Ras GTPase activity|positive regulation of Ras protein signal transduction|,Ras guanyl-nucleotide exchange factor activity|calcium ion binding|diacylglycerol binding|GTP-dependent protein binding|,10,-1,0.628,9,-3.3,4.34,-3.1,4.35,0.0974,-8.4,0.8
ENSMUSG00000025326,UBE3A,ubiquitin protein ligase E3A,proteasome complex|nucleus|cytoplasm|cytosol|,ovarian follicle development|proteolysis|ubiquitin-dependent protein catabolic process|brain development|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|androgen receptor signaling pathway|sperm entry|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|protein autoubiquitination|prostate gland growth|protein K48-linked ubiquitination|,transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|ligase activity|,9,3.4,3.46,9,-5.8,4.89,-4.9,4.35,0.0974,-11,7.6
ENSMUSG00000030847,BAG3,BCL2-associated athanogene 3,cytoplasm|cytosol|plasma membrane|Z disc|neuron projection|,protein folding|brain development|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of striated muscle cell apoptotic process|spinal cord development|negative regulation of apoptotic process|protein stabilization|cellular response to mechanical stimulus|extrinsic apoptotic signaling pathway in absence of ligand|,protein binding|protein complex binding|chaperone binding|,0,0,0,1,4.2,4.5,4.2,4.33,0.0983,0.4,8
ENSMUSG00000026536,MNDA,myeloid cell nuclear differentiation antigen,nucleus|cytoplasm|extracellular vesicular exosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cellular defense response|cellular response to DNA damage stimulus|negative regulation of B cell proliferation|positive regulation of apoptotic process|B cell receptor signaling pathway|",DNA binding|protein binding|,9,-2.7,4.23,10,-1.2,0.612,-2.5,4.33,0.0983,-5.4,3.4
ENSMUSG00000089960,UGT1A1,"UDP glucuronosyltransferase 1 family, polypeptide A1",endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cytochrome complex|,liver development|porphyrin-containing compound metabolic process|bilirubin conjugation|xenobiotic metabolic process|acute-phase response|response to nutrient|digestion|steroid metabolic process|estrogen metabolic process|drug metabolic process|organ regeneration|response to lipopolysaccharide|heme catabolic process|response to drug|retinoic acid metabolic process|response to starvation|negative regulation of catalytic activity|small molecule metabolic process|negative regulation of steroid metabolic process|heterocycle metabolic process|flavone metabolic process|cellular glucuronidation|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|biphenyl catabolic process|cellular response to ethanol|cellular response to glucocorticoid stimulus|negative regulation of cellular glucuronidation|,retinoic acid binding|enzyme inhibitor activity|steroid binding|glucuronosyltransferase activity|glucuronosyltransferase activity|enzyme binding|protein homodimerization activity|protein homodimerization activity|protein heterodimerization activity|protein heterodimerization activity|,3,-5.1,2.96,4,-4.5,1.74,-4.8,4.33,0.0983,-11,-0.8
ENSMUSG00000021112,MPP5,"membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)",nucleus|cytoplasm|plasma membrane|plasma membrane|tight junction|endomembrane system|myelin sheath adaxonal region|lateral loop|Schmidt-Lanterman incisure|protein complex|extracellular vesicular exosome|,morphogenesis of an epithelial sheet|peripheral nervous system myelin maintenance|myelin assembly|cell junction assembly|protein localization to myelin sheath abaxonal region|cell-cell junction organization|tight junction assembly|establishment of protein localization to plasma membrane|,protein binding|protein domain specific binding|,10,-3.2,4.47,9,-1.1,1.31,-2.9,4.33,0.0983,-5.9,0.1
ENSMUSG00000070847,VMN2R30,"vomeronasal 2, receptor 30",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,5,-2.3,0.849,3,-2.1,3.72,-2.2,4.33,0.0983,-6,1.5
ENSMUSG00000033904,CCP110,centriolar coiled coil protein 110kDa,centrosome|centriole|cytosol|protein complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|centriole replication|cell projection organization|regulation of cytokinesis|centrosome duplication|centrosome duplication|,protein binding|,10,-3,1.58,10,-3.4,3.04,-3.1,4.32,0.0985,-8.5,0
ENSMUSG00000025038,EFHC2,EF-hand domain (C-terminal) containing 2,None,None,calcium ion binding|,1,1,0.358,1,4.7,4.66,4.6,4.31,0.0988,0.7,9
ENSMUSG00000023944,HSP90AB1,"heat shock protein 90kDa alpha (cytosolic), class B member 1",cytoplasm|mitochondrion|cytosol|COP9 signalosome|cell surface|membrane|inclusion body|basolateral plasma membrane|apical plasma membrane|brush border membrane|melanosome|extracellular vesicular exosome|,"placenta development|protein folding|response to unfolded protein|axon guidance|response to salt stress|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein import into nucleus, translocation|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of neuron apoptotic process|innate immune response|positive regulation of nitric oxide biosynthetic process|positive regulation of cell size|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|cellular response to interleukin-4|cellular response to organic cyclic compound|positive regulation of protein serine/threonine kinase activity|",UTP binding|CTP binding|double-stranded RNA binding|protein binding|ATP binding|GTP binding|sulfonylurea receptor binding|protein kinase binding|MHC class II protein complex binding|nitric-oxide synthase regulator activity|TPR domain binding|dATP binding|ion channel binding|poly(A) RNA binding|unfolded protein binding|,10,-1.6,1.26,10,-1.9,3.31,-1.6,4.31,0.0988,-5.9,2.2
ENSMUSG00000025016,TM9SF3,transmembrane 9 superfamily member 3,integral component of membrane|,None,None,0,0,0,2,3.7,4.47,3.7,4.3,0.0992,0.5,8
ENSMUSG00000079109,PMS2,PMS2 postmeiotic segregation increased 2 (S. cerevisiae),nucleus|nucleus|cytoplasm|microtubule cytoskeleton|MutLalpha complex|,ATP catabolic process|mismatch repair|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|response to drug|nucleic acid phosphodiester bond hydrolysis|,DNA binding|single-stranded DNA binding|endonuclease activity|protein binding|ATP binding|ATPase activity|single base insertion or deletion binding|MutSalpha complex binding|,9,0.1,0.00304,10,-2.7,5.21,-2.4,4.3,0.0992,-7.2,1.5
ENSMUSG00000053158,FES,"FES proto-oncogene, tyrosine kinase",cytoplasm|Golgi apparatus|cytosol|focal adhesion|microtubule cytoskeleton|cytoplasmic membrane-bounded vesicle|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|,protein phosphorylation|multicellular organismal development|axon guidance|cell proliferation|regulation of cell shape|positive regulation of neuron projection development|peptidyl-tyrosine phosphorylation|regulation of cell adhesion|positive regulation of microtubule polymerization|regulation of cell proliferation|regulation of mast cell degranulation|regulation of cell differentiation|positive regulation of myeloid cell differentiation|protein autophosphorylation|regulation of vesicle-mediated transport|regulation of cell motility|positive regulation of actin cytoskeleton reorganization|,protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|immunoglobulin receptor binding|phosphatidylinositol binding|,0,0,0,1,4.2,4.46,4.2,4.29,0.0996,0.4,8
ENSMUSG00000033227,WNT6,"wingless-type MMTV integration site family, member 6",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|,"branching involved in ureteric bud morphogenesis|axis specification|positive regulation of gene expression|Wnt signaling pathway|neuron differentiation|neuron differentiation|odontogenesis of dentin-containing tooth|cell fate commitment|positive regulation of transcription, DNA-templated|epithelial-mesenchymal cell signaling|cornea development in camera-type eye|positive regulation of tooth mineralization|cellular response to retinoic acid|nephron tubule formation|",frizzled binding|,10,-1.2,1.3,10,-2.7,4.1,-2.5,4.29,0.0996,-6.4,0.5
ENSMUSG00000060126,TPT1,"tumor protein, translationally-controlled 1",extracellular space|nucleus|nucleoplasm|cytoplasm|cytoplasm|multivesicular body|tubulin complex|,calcium ion transport|cellular calcium ion homeostasis|response to virus|stem cell maintenance|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of ectoderm development|,calcium ion binding|protein binding|transcription factor binding|poly(A) RNA binding|,5,-2,3.7,7,-1.3,1.23,-1.8,4.29,0.0996,-4.8,0.1
ENSMUSG00000044709,GEMIN7,gem (nuclear organelle) associated protein 7,nucleus|nucleoplasm|nucleoplasm|cytoplasm|cytosol|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|Gemini of coiled bodies|,"spliceosomal snRNP assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|gene expression|RNA metabolic process|ncRNA metabolic process|",protein binding|,1,1.1,0.407,1,4.4,4.56,4.4,4.28,0.0999,0.6,9
ENSMUSG00000044068,ZRSR1,"zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1",nucleus|ribonucleoprotein complex|,biological_process|,nucleotide binding|RNA binding|metal ion binding|,10,3.7,0.729,9,4.3,3.92,4.1,4.28,0.0999,-2.2,9
ENSMUSG00000010755,CARS,cysteinyl-tRNA synthetase,cytoplasm|cytoplasm|cytosol|cytosol|,tRNA aminoacylation for protein translation|cysteinyl-tRNA aminoacylation|gene expression|,tRNA binding|tRNA binding|tRNA binding|cysteine-tRNA ligase activity|cysteine-tRNA ligase activity|protein binding|ATP binding|protein homodimerization activity|protein homodimerization activity|metal ion binding|,5,-2.9,2.59,6,-2.1,2.11,-2.7,4.27,0.1,-6.5,-0.1
ENSMUSG00000034453,POLR3B,polymerase (RNA) III (DNA directed) polypeptide B,nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|,transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus|,DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|metal ion binding|,10,4.9,6.53,8,0.2,0.0202,3.9,4.27,0.1,-0.5,11.8
ENSMUSG00000024854,POLD4,"polymerase (DNA-directed), delta 4, accessory subunit",nucleus|nucleoplasm|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|positive regulation of endothelial cell proliferation|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|",DNA-directed DNA polymerase activity|protein binding|,10,-5.7,1.23,9,-3,4.29,-3.2,4.27,0.1,-9.3,0.4
ENSMUSG00000020914,TOP2A,topoisomerase (DNA) II alpha 170kDa,nuclear chromosome|condensed chromosome|nucleus|nucleoplasm|nucleoplasm|nucleolus|centriole|DNA topoisomerase complex (ATP-hydrolyzing)|viral integration complex|protein complex|,mitotic cell cycle|resolution of meiotic recombination intermediates|sister chromatid segregation|ATP catabolic process|ATP catabolic process|DNA replication|DNA topological change|DNA ligation|DNA unwinding involved in DNA replication|DNA repair|mitotic recombination|cellular response to DNA damage stimulus|chromosome segregation|apoptotic chromosome condensation|embryonic cleavage|positive regulation of apoptotic process|mitotic DNA integrity checkpoint|positive regulation of viral genome replication|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of transcription from RNA polymerase II promoter|phosphatidylinositol-mediated signaling|,"magnesium ion binding|DNA binding|chromatin binding|DNA topoisomerase type II (ATP-hydrolyzing) activity|protein kinase C binding|protein binding|ATP binding|protein C-terminus binding|DNA-dependent ATPase activity|drug binding|DNA binding, bending|enzyme binding|protein homodimerization activity|histone deacetylase binding|ubiquitin binding|poly(A) RNA binding|protein heterodimerization activity|",5,5,4.42,4,-5.6,5.37,-4.4,4.27,0.1,-11,7.9
ENSMUSG00000042029,NCAPG2,"non-SMC condensin II complex, subunit G2",nucleus|nucleoplasm|membrane|,mitotic cell cycle|inner cell mass cell proliferation|mitotic nuclear division|chromosome condensation|,protein binding|methylated histone binding|,10,-3,5.24,10,4.4,1.99,-2.6,4.26,0.101,-6.5,5.8
ENSMUSG00000078173,LENEP,lens epithelial protein,None,multicellular organismal development|,DNA binding|,1,3.7,4.42,0,0,0,3.7,4.25,0.101,0.4,8
ENSMUSG00000026196,BARD1,BRCA1 associated RING domain 1,ubiquitin ligase complex|nucleus|nucleus|nucleolus|cytoplasm|BRCA1-BARD1 complex|intracellular membrane-bounded organelle|BRCA1-A complex|,tissue homeostasis|DNA repair|cellular response to DNA damage stimulus|cell cycle arrest|protein ubiquitination|negative regulation of mRNA 3'-end processing|regulation of phosphorylation|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of protein catabolic process|negative regulation of protein export from nucleus|protein K6-linked ubiquitination|,RNA binding|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|kinase binding|protein homodimerization activity|protein heterodimerization activity|,9,-1.6,1.92,9,-3.7,3.01,-2.2,4.25,0.101,-7.9,0.3
ENSMUSG00000000149,GNA12,guanine nucleotide binding protein (G protein) alpha 12,heterotrimeric G-protein complex|plasma membrane|brush border membrane|,in utero embryonic development|GTP catabolic process|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of cell shape|regulation of fibroblast migration|cell differentiation|platelet activation|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|response to drug|embryonic digit morphogenesis|,GTPase activity|signal transducer activity|protein binding|GTP binding|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|metal ion binding|,10,-2.5,2.25,10,-1.6,2.41,-1.7,4.25,0.101,-7.7,2.2
ENSMUSG00000027965,OLFM3,olfactomedin 3,extracellular space|Golgi apparatus|cell junction|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|synapse|,eye photoreceptor cell development|,protein binding|,10,-1.7,0.765,10,-3,4,-2.9,4.24,0.102,-7.2,1
ENSMUSG00000031104,RAB33A,"RAB33A, member RAS oncogene family",plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|protein transport|antigen processing and presentation|,GTPase activity|protein binding|GTP binding|,10,2,2.86,10,1.6,1.65,1.9,4.23,0.102,-4.5,6.4
ENSMUSG00000023456,TPI1,triosephosphate isomerase 1,extracellular space|nucleus|cytosol|extracellular vesicular exosome|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|gluconeogenesis|glycolytic process|glycolytic process|pentose-phosphate shunt|embryo development|glyceraldehyde-3-phosphate metabolic process|small molecule metabolic process|,triose-phosphate isomerase activity|triose-phosphate isomerase activity|triose-phosphate isomerase activity|protein binding|,10,-3,4.52,10,-1.6,0.495,-2.9,4.23,0.102,-7.6,0.4
ENSMUSG00000032680,6820408C15RIK,RIKEN cDNA 6820408C15 gene,cellular_component|,biological_process|,molecular_function|,10,-4,3.2,10,-1.4,3.06,-3.5,4.22,0.103,-9.1,1.4
ENSMUSG00000006527,SFMBT1,Scm-like with four mbt domains 1,nucleus|,"transcription, DNA-templated|spermatogenesis|chromatin modification|cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|negative regulation of muscle organ development|",transcription corepressor activity|protein binding|histone binding|,0,0,0,1,4.1,4.39,4.1,4.22,0.103,0.4,8
ENSMUSG00000017165,GAST,gastrin,extracellular region|,signal transduction|G-protein coupled receptor signaling pathway|,hormone activity|protein binding|,10,-0.3,0.22,10,-4.7,5.48,-1.4,4.21,0.104,-10,-0.1
ENSMUSG00000095930,NIM1,N/A,None,None,None,0,0,0,1,4,4.38,4,4.21,0.104,0.3,8
ENSMUSG00000027209,FAM227B,"family with sequence similarity 227, member B",None,None,None,0,0,0,1,4,4.37,4,4.2,0.104,0.3,8
ENSMUSG00000021022,PPP2R3C,"protein phosphatase 2, regulatory subunit B'', gamma",nucleus|cytoplasm|centrosome|,B cell homeostasis|regulation of antimicrobial humoral response|activation of protein kinase activity|T cell homeostasis|positive regulation of B cell differentiation|spleen development|regulation of mitochondrial depolarization|,calcium ion binding|,8,-2.4,4.17,10,-0.8,1.06,-1.9,4.2,0.104,-6,1.4
ENSMUSG00000038456,DENND2A,DENN/MADD domain containing 2A,cytoplasm|actin cytoskeleton|,"protein transport|positive regulation of Rab GTPase activity|retrograde transport, endosome to Golgi|",Rab guanyl-nucleotide exchange factor activity|,10,4.8,0.0159,10,-3.5,5.15,-1.4,4.18,0.105,-10.2,0.4
ENSMUSG00000020460,RPS27A,ribosomal protein S27a,nucleoplasm|cytosol|plasma membrane|endosome membrane|small ribosomal subunit|membrane|cytosolic small ribosomal subunit|endocytic vesicle membrane|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|mitotic cell cycle|toll-like receptor signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|carbohydrate metabolic process|glycogen biosynthetic process|glucose metabolic process|DNA repair|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|Notch receptor processing|I-kappaB kinase/NF-kappaB signaling|JNK cascade|fibroblast growth factor receptor signaling pathway|gene expression|viral process|RNA metabolic process|mRNA metabolic process|endosomal transport|viral life cycle|virion assembly|viral protein processing|viral transcription|cytokine-mediated signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|ion transmembrane transport|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|cellular protein metabolic process|small molecule metabolic process|innate immune response|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to hypoxia|intracellular transport of virus|apoptotic signaling pathway|",structural constituent of ribosome|poly(A) RNA binding|metal ion binding|,3,4,3.44,4,-2.8,4.59,-2.7,4.17,0.105,-8,6.7
ENSMUSG00000028974,DFFA,"DNA fragmentation factor, 45kDa, alpha polypeptide",nuclear chromatin|nucleus|nucleoplasm|cytoplasm|cytosol|cytosol|,apoptotic DNA fragmentation|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|positive regulation of apoptotic process|thymocyte apoptotic process|negative regulation of execution phase of apoptosis|negative regulation of apoptotic DNA fragmentation|,protein binding|,10,-0.7,0.902,10,-3,3.92,-4,4.17,0.105,-10.4,3.2
ENSMUSG00000026648,DCLRE1C,DNA cross-link repair 1C,nucleus|,"telomere maintenance|DNA catabolic process, endonucleolytic|double-strand break repair|DNA recombination|response to ionizing radiation|B cell differentiation|nucleic acid phosphodiester bond hydrolysis|",single-stranded DNA endodeoxyribonuclease activity|5'-3' exonuclease activity|,10,1.4,1.32,10,-1.7,3.59,-1.6,4.16,0.106,-6.4,2.6
ENSMUSG00000037108,ZCWPW1,"zinc finger, CW type with PWWP domain 1",None,None,zinc ion binding|,0,0,0,1,4,4.32,4,4.16,0.106,0.3,8
ENSMUSG00000054893,ZFP667,zinc finger protein 667,intracellular|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",nucleic acid binding|DNA binding|metal ion binding|,1,-4.5,2.46,1,-3,2.26,-4.3,4.16,0.106,-9,-0.5
ENSMUSG00000027845,DCLRE1B,DNA cross-link repair 1B,"chromosome, telomeric region|nucleus|cytoplasm|centrosome|",cell cycle checkpoint|telomere maintenance|DNA repair|telomeric loop formation|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|,protein binding|5'-3' exonuclease activity|,10,-1.4,1.79,10,-1.9,2.81,-1.6,4.15,0.106,-5.9,4.3
ENSMUSG00000041046,RAMP3,receptor (G protein-coupled) activity modifying protein 3,intracellular|lysosome|plasma membrane|plasma membrane|plasma membrane|integral component of plasma membrane|cell surface|receptor complex|,"positive regulation of receptor recycling|calcium ion transport|intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway|protein transport|receptor internalization|negative regulation of transcription, DNA-templated|cellular response to estradiol stimulus|protein localization to plasma membrane|G-protein coupled receptor signaling pathway involved in heart process|positive regulation of establishment of protein localization to plasma membrane|",receptor activity|protein binding|protein transporter activity|coreceptor activity|,1,3.7,4.32,0,0,0,3.7,4.15,0.106,0.3,8
ENSMUSG00000036819,JMJD4,jumonji domain containing 4,None,None,protein binding|,1,4.3,4.88,1,-1.7,0.42,4.2,4.14,0.107,-0.7,9
ENSMUSG00000038676,UCN,urocortin,extracellular region|dendrite|varicosity|perikaryon|axon terminus|,"inflammatory response|response to oxidative stress|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|female pregnancy|associative learning|aerobic respiration|positive regulation of gene expression|negative regulation of gene expression|pancreatic juice secretion|positive regulation of cell growth|positive regulation of cAMP biosynthetic process|negative regulation of histone deacetylation|neuron projection development|negative regulation of appetite|response to estradiol|positive regulation of interleukin-6 production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|activation of protein kinase A activity|gastric emptying|drinking behavior|negative regulation of apoptotic process|positive regulation of vascular permeability|positive regulation of translation|positive regulation of DNA replication|negative regulation of blood pressure|negative regulation of cell size|positive regulation of vasodilation|negative regulation of hormone secretion|response to pain|response to glucocorticoid|positive regulation of corticotropin secretion|regulation of synaptic transmission, glutamatergic|positive regulation of cardiac muscle contraction|negative regulation of gastric acid secretion|negative regulation of necrotic cell death|positive regulation of calcium ion import|negative regulation of neuron death|negative regulation of feeding behavior|positive regulation of behavioral fear response|",neuropeptide hormone activity|protein binding|histone deacetylase inhibitor activity|corticotropin-releasing hormone receptor 1 binding|corticotropin-releasing hormone receptor 2 binding|,10,-3.2,3.28,10,-1.1,1.54,-1.6,4.14,0.107,-6,0.8
ENSMUSG00000093485,GM20708,N/A,None,None,None,3,-1.8,1.21,3,-2,3.19,-1.9,4.13,0.107,-6,-0.1
ENSMUSG00000042605,ATXN2,ataxin 2,nucleus|cytoplasm|Golgi apparatus|trans-Golgi network|polysome|cytoplasmic stress granule|membrane|ribonucleoprotein complex|perinuclear region of cytoplasm|,negative regulation of receptor internalization|regulation of translation|cell death|RNA metabolic process|cerebellar Purkinje cell differentiation|cytoplasmic mRNA processing body assembly|stress granule assembly|negative regulation of multicellular organism growth|neuron projection morphogenesis|homeostasis of number of cells|RNA transport|neuromuscular process|,RNA binding|epidermal growth factor receptor binding|protein binding|protein C-terminus binding|poly(A) RNA binding|,1,3.7,4.3,0,0,0,3.7,4.13,0.107,0.3,8
ENSMUSG00000054626,XLR,X-linked lymphocyte-regulated,cellular_component|,biological_process|,molecular_function|,5,-4.8,5.76,6,-0.4,0.128,-4.7,4.13,0.107,-10,-0.2
ENSMUSG00000018286,PSMB6,"proteasome (prosome, macropain) subunit, beta type, 6",nucleus|nucleoplasm|cytosol|proteasome core complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",endopeptidase activity|threonine-type endopeptidase activity|,7,0,0,8,-1.9,5.3,-1.8,4.13,0.107,-6.1,0.1
ENSMUSG00000041797,ABCA9,"ATP-binding cassette, sub-family A (ABC1), member 9",mitochondrion|integral component of membrane|,ATP catabolic process|transport|,ATP binding|ATPase activity|,9,1.7,1.15,10,-2.2,3.84,-2.3,4.13,0.107,-7.7,4.6
ENSMUSG00000054622,D730045B01RIK,RIKEN cDNA D730045B01 gene,cellular_component|,biological_process|,molecular_function|,1,3.7,4.28,0,0,0,3.7,4.11,0.108,0.3,8
ENSMUSG00000024276,ZFP397,zinc finger protein 397,cellular_component|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",molecular_function|metal ion binding|,1,4,4.81,1,0,0,4,4.11,0.108,0.5,9
ENSMUSG00000023919,CENPQ,centromere protein Q,"chromosome, centromeric region|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|intermediate filament cytoskeleton|",mitotic cell cycle|nucleosome assembly|centromere-specific nucleosome assembly|,None,10,1.5,2.46,9,2,1.93,1.7,4.11,0.108,-4.2,6.6
ENSMUSG00000044548,DACT1,dishevelled-binding antagonist of beta-catenin 1,nucleus|cytoplasm|cell junction|beta-catenin destruction complex|beta-catenin destruction complex|synapse|,"negative regulation of transcription from RNA polymerase II promoter|gastrulation with mouth forming second|Wnt signaling pathway|positive regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|regulation of protein stability|regulation of catenin import into nucleus|positive regulation of catenin import into nucleus|positive regulation of fat cell differentiation|positive regulation of protein catabolic process|negative regulation of JNK cascade|embryonic hindgut morphogenesis|dendrite morphogenesis|synapse organization|negative regulation of canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway|negative regulation of G1/S transition of mitotic cell cycle|",protein kinase C binding|protein binding|beta-catenin binding|protein kinase A binding|delta-catenin binding|,10,-3.2,3.38,10,-2.3,1.18,-2.8,4.11,0.108,-7.5,1
ENSMUSG00000079144,A130010J15RIK,RIKEN cDNA A130010J15 gene,cellular_component|,biological_process|,molecular_function|,1,4.4,4.85,1,-2.2,0.757,4.3,4.1,0.109,-1.9,9
ENSMUSG00000038775,VILL,villin-like,actin cytoskeleton|,cytoskeleton organization|actin filament capping|,actin binding|structural constituent of cytoskeleton|,10,1.3,0.788,10,-4.5,4.45,-1.3,4.1,0.109,-10,1.7
ENSMUSG00000039830,OLIG2,oligodendrocyte lineage transcription factor 2,nucleus|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|spinal cord motor neuron differentiation|spinal cord oligodendrocyte cell fate specification|thalamus development|myelination|negative regulation of neuron differentiation|neuron fate commitment|positive regulation of oligodendrocyte differentiation|,DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein homodimerization activity|HMG box domain binding|,10,-3.7,6.79,10,2.6,2.89,-3.5,4.09,0.109,-8.6,3.6
ENSMUSG00000002109,DDB2,"damage-specific DNA binding protein 2, 48kDa",nucleoplasm|Cul4B-RING E3 ubiquitin ligase complex|protein complex|,"protein polyubiquitination|nucleotide-excision repair, DNA damage removal|DNA repair|nucleotide-excision repair|pyrimidine dimer repair|response to UV|histone H2A monoubiquitination|protein autoubiquitination|UV-damage excision repair|",DNA binding|damaged DNA binding|ubiquitin-protein transferase activity|protein binding|,10,-1.9,2.66,10,-1.4,1.86,-1.6,4.09,0.109,-4.8,0.6
ENSMUSG00000032089,IL10RA,"interleukin 10 receptor, alpha",cytoplasm|plasma membrane|integral component of membrane|,signal transduction|cytokine-mediated signaling pathway|cytokine-mediated signaling pathway|response to lipopolysaccharide|,signal transducer activity|receptor activity|interleukin-10 receptor activity|protein binding|interleukin-10 binding|,1,3.6,4.25,0,0,0,3.6,4.08,0.11,0.2,8
ENSMUSG00000024906,MUS81,MUS81 structure-specific endonuclease subunit,nucleus|intercellular bridge|,"DNA catabolic process, endonucleolytic|DNA repair|DNA recombination|response to intra-S DNA damage checkpoint signaling|",DNA binding|protein binding|metal ion binding|3'-flap endonuclease activity|,10,-2.9,1.08,10,-5.5,3.59,-4.4,4.08,0.11,-9.6,0
ENSMUSG00000038155,GSTP2,"glutathione S-transferase, pi 2",extracellular space|intracellular|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|extracellular vesicular exosome|TRAF2-GSTP1 complex|,glutathione metabolic process|metabolic process|,glutathione transferase activity|glutathione transferase activity|drug binding|transferase activity|S-nitrosoglutathione binding|dinitrosyl-iron complex binding|glutathione binding|,10,-3.8,0.0696,10,-4.2,4.22,-4.1,4.07,0.11,-10.3,0.4
ENSMUSG00000003037,RAB8A,"RAB8A, member RAS oncogene family",Golgi membrane|centrosome|plasma membrane|cilium|cilium|postsynaptic density|dendrite|cytoplasmic vesicle membrane|phagocytic vesicle membrane|nonmotile primary cilium|neuronal cell body|phagocytic vesicle|recycling endosome membrane|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|GTP catabolic process|vesicle docking involved in exocytosis|small GTPase mediated signal transduction|axonogenesis|protein transport|cellular response to insulin stimulus|cilium assembly|cilium assembly|regulation of long-term neuronal synaptic plasticity|Golgi vesicle fusion to target membrane|regulation of protein transport|membrane organization|protein localization to plasma membrane|,GTPase activity|protein binding|GTP binding|Rab GTPase binding|GDP binding|protein kinase binding|,8,-0.8,0.782,10,-1.6,3.78,-1.5,4.07,0.11,-6,0.5
ENSMUSG00000037020,WDR62,WD repeat domain 62,spindle pole|nucleus|cytoplasm|,cerebral cortex development|neurogenesis|,None,0,0,0,1,3.9,4.23,3.9,4.07,0.11,0.2,8
ENSMUSG00000052748,SWT1,SWT1 RNA endoribonuclease homolog (S. cerevisiae),None,None,None,1,4.4,4.82,1,-1.1,0.16,4.4,4.07,0.11,0.5,10
ENSMUSG00000001134,UXT,"ubiquitously-expressed, prefoldin-like chaperone",gamma-tubulin complex|nucleus|cytoplasm|centrosome|microtubule organizing center|cytoskeleton|prefoldin complex|,"negative regulation of transcription from RNA polymerase II promoter|microtubule cytoskeleton organization|transcription, DNA-templated|protein folding|mitochondrion transport along microtubule|centrosome organization|",RNA polymerase II transcription corepressor activity|chromatin binding|protein binding|microtubule binding|beta-tubulin binding|unfolded protein binding|,10,3.6,6.45,9,-1.2,0.825,3.4,4.06,0.111,-2.7,8.6
ENSMUSG00000079608,STARD6,StAR-related lipid transfer (START) domain containing 6,None,lipid transport|,lipid binding|,1,3.6,4.23,0,0,0,3.6,4.06,0.111,0.2,8
ENSMUSG00000057522,SPOP,speckle-type POZ protein,nucleus|nuclear speck|Cul3-RING ubiquitin ligase complex|,protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|,protein binding|ubiquitin protein ligase binding|,1,3.6,4.23,0,0,0,3.6,4.06,0.111,0.2,8
ENSMUSG00000030793,PYCARD,PYD and CARD domain containing,extracellular region|nucleus|nucleus|nucleolus|cytoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|IkappaB kinase complex|IkappaB kinase complex|neuronal cell body|NLRP1 inflammasome complex|NLRP3 inflammasome complex|AIM2 inflammasome complex|,"myeloid dendritic cell activation|activation of innate immune response|positive regulation of defense response to virus by host|myeloid dendritic cell activation involved in immune response|positive regulation of antigen processing and presentation of peptide antigen via MHC class II|positive regulation of adaptive immune response|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|signal transduction|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of actin filament polymerization|regulation of protein stability|negative regulation of NF-kappaB transcription factor activity|regulation of Rac GTPase activity|interleukin-1 beta production|negative regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|tumor necrosis factor-mediated signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|positive regulation of activated T cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|macropinocytosis|innate immune response|positive regulation of JNK cascade|positive regulation of interleukin-1 beta secretion|regulation of inflammatory response|positive regulation of phagocytosis|defense response to Gram-negative bacterium|positive regulation of T cell activation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of protein serine/threonine kinase activity|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of chemokine secretion|positive regulation of release of cytochrome c from mitochondria|positive regulation of T cell migration|positive regulation of interleukin-8 secretion|positive regulation of interleukin-6 secretion|positive regulation of cysteine-type endopeptidase activity|positive regulation of interleukin-10 secretion|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|",protease binding|protein binding|cysteine-type endopeptidase activator activity involved in apoptotic process|Pyrin domain binding|protein homodimerization activity|ion channel binding|,10,2.1,3.37,10,-2.5,3.71,-2.2,4.05,0.111,-7.5,4.5
ENSMUSG00000027944,HAX1,HCLS1 associated protein X-1,nuclear envelope|transcription factor complex|mitochondrion|endoplasmic reticulum|actin cytoskeleton|cytoplasmic membrane-bounded vesicle|sarcoplasmic reticulum|lamellipodium|nuclear membrane|,positive regulation of phosphatidylinositol 3-kinase signaling|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|positive regulation of actin cytoskeleton reorganization|,protein binding|interleukin-1 binding|protein N-terminus binding|,10,2.4,3.25,9,-2.7,4.6,-1.8,4.04,0.112,-6.2,4.8
ENSMUSG00000058147,XLR3C,X-linked lymphocyte-regulated 3C,cellular_component|,biological_process|,molecular_function|,2,-5.1,5.6,3,5.2,4.11,-5,4.03,0.112,-10,8.5
ENSMUSG00000030790,ADM,adrenomedullin,extracellular region|extracellular space|cytoplasm|,vasculogenesis|response to hypoxia|neural tube closure|regulation of the force of heart contraction|G-protein coupled receptor internalization|cAMP biosynthetic process|progesterone biosynthetic process|signal transduction|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|heart development|female pregnancy|aging|blood circulation|androgen metabolic process|positive regulation of cell proliferation|negative regulation of cell proliferation|response to cold|response to wounding|positive regulation of heart rate|cAMP-mediated signaling|positive regulation of cAMP biosynthetic process|organ regeneration|neuron projection regeneration|receptor internalization|response to lipopolysaccharide|response to insulin|odontogenesis of dentin-containing tooth|response to starvation|positive regulation of apoptotic process|negative regulation of vascular permeability|positive regulation of angiogenesis|negative regulation of vasoconstriction|positive regulation of vasodilation|hormone secretion|developmental growth|response to glucocorticoid|branching involved in labyrinthine layer morphogenesis|spongiotrophoblast layer development|vascular smooth muscle cell development|positive regulation of vasculogenesis|,receptor binding|hormone activity|protein binding|adrenomedullin receptor binding|,10,2.4,3.13,10,1.4,1.45,1.8,4.03,0.112,-7,7.9
ENSMUSG00000027347,RASGRP1,RAS guanyl releasing protein 1 (calcium and DAG-regulated),Golgi membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|membrane|mast cell granule|,cytokine production|inflammatory response to antigenic stimulus|signal transduction|Ras protein signal transduction|blood coagulation|regulation of phosphatidylinositol 3-kinase signaling|cell differentiation|platelet activation|secretory granule localization|activation of Rho GTPase activity|Fc-epsilon receptor signaling pathway|mast cell degranulation|innate immune response|vesicle transport along microtubule|,guanyl-nucleotide exchange factor activity|calcium ion binding|lipid binding|,10,-4.4,3.98,10,-1,1.4,-2.2,4.03,0.112,-7,3.9
ENSMUSG00000009905,KDSR,3-ketodihydrosphingosine reductase,extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|,sphingolipid metabolic process|3-keto-sphinganine metabolic process|sphingolipid biosynthetic process|small molecule metabolic process|oxidation-reduction process|,3-dehydrosphinganine reductase activity|,9,-3.7,2.1,9,-1.8,2.46,-2.4,4.01,0.113,-7.2,2.4
ENSMUSG00000048442,SMIM5,small integral membrane protein 5,integral component of membrane|,None,None,0,0,0,1,3.8,4.18,3.8,4.01,0.113,0.2,8
ENSMUSG00000025184,R3HCC1L,R3H domain and coiled-coil containing 1-like,exon-exon junction complex|,None,nucleotide binding|,0,0,0,1,3.8,4.18,3.8,4.01,0.113,0.2,8
ENSMUSG00000020340,CYFIP2,cytoplasmic FMR1 interacting protein 2,cytoplasm|cytosol|membrane|cell junction|neuron projection|synapse|perinuclear region of cytoplasm|extracellular vesicular exosome|,apoptotic process|single organismal cell-cell adhesion|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|positive regulation of proteolysis|activation of cysteine-type endopeptidase activity|,protein binding|,1,3.6,4.17,0,0,0,3.6,4.01,0.113,0.2,8
ENSMUSG00000002812,FLII,flightless I homolog (Drosophila),nucleus|cytoplasm|microtubule organizing center|focal adhesion|,"transcription, DNA-templated|regulation of transcription, DNA-templated|muscle contraction|multicellular organismal development|",actin binding|protein binding|,10,-2.9,6.52,10,0.3,0.0353,-2.7,4.01,0.113,-6.4,1.3
ENSMUSG00000038482,TFDP1,transcription factor Dp-1,nucleoplasm|transcription factor complex|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|apoptotic process|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|cell proliferation|gene expression|positive regulation of transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|protein domain specific binding|,7,-0.4,0.157,8,-2.6,4.15,-2.5,4,0.114,-8,0.3
ENSMUSG00000042340,CTF1,cardiotrophin 1,extracellular region|extracellular space|,cell-cell signaling|nervous system development|muscle organ development|cell proliferation|positive regulation of cell proliferation|neuron development|leukemia inhibitory factor signaling pathway|,cytokine activity|leukemia inhibitory factor receptor binding|,0,0,0,1,3.8,4.17,3.8,4,0.114,0.2,8
ENSMUSG00000032097,DDX6,DEAD (Asp-Glu-Ala-Asp) box helicase 6,cytoplasmic mRNA processing body|cytoplasm|cytosol|cytoplasmic stress granule|membrane|RISC complex|intracellular membrane-bounded organelle|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|ATP catabolic process|gene expression|RNA metabolic process|mRNA metabolic process|cytoplasmic mRNA processing body assembly|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|",RNA helicase activity|helicase activity|protein binding|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,1,-3,1.43,1,4.7,4.72,4.7,4,0.114,-4.1,9
ENSMUSG00000026883,DAB2IP,DAB2 interacting protein,cytoplasm|plasma membrane|endocytic vesicle|axon|dendrite|intrinsic component of the cytoplasmic side of the plasma membrane|neuronal cell body membrane|neuronal cell body|cerebellar mossy fiber|climbing fiber|extracellular vesicular exosome|parallel fiber|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|activation of MAPKKK activity|angiogenesis|negative regulation of protein phosphorylation|negative regulation of protein phosphorylation|transformed cell apoptotic process|inflammatory response|response to unfolded protein|cell cycle|I-kappaB phosphorylation|activation of JUN kinase activity|negative regulation of cell proliferation|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of endothelial cell migration|negative regulation of epithelial cell migration|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of epithelial to mesenchymal transition|positive regulation of neuron projection development|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of angiogenesis|cell motility involved in cerebral cortex radial glia guided migration|layer formation in cerebral cortex|negative regulation of cell growth|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|regulation of ARF GTPase activity|positive regulation of Ras GTPase activity|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of GTPase activity|negative regulation of Ras GTPase activity|tube formation|negative regulation of catenin import into nucleus|cellular response to vascular endothelial growth factor stimulus|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor receptor-2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein complex assembly|negative regulation of MAP kinase activity|negative regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|negative regulation of phosphatidylinositol 3-kinase activity|cellular protein catabolic process|innate immune response|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|negative regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|negative regulation of fibroblast proliferation|neuron projection morphogenesis|negative regulation of epithelial cell proliferation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of G0 to G1 transition|negative regulation of ERK1 and ERK2 cascade|positive regulation of cell cycle arrest|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|negative regulation of protein serine/threonine kinase activity|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|endothelial cell apoptotic process|negative regulation of canonical Wnt signaling pathway|positive regulation of synapse maturation|positive regulation of dendrite development|regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of proteasomal protein catabolic process|negative regulation of cyclin catabolic process|positive regulation of neuron migration|positive regulation of apoptotic signaling pathway|",Ras GTPase activator activity|Ras GTPase activator activity|death receptor binding|protein binding|SH3 domain binding|kinase binding|protein kinase binding|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|phosphatidylinositol-3-phosphate binding|protein complex binding|signaling adaptor activity|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding|protein homodimerization activity|vascular endothelial growth factor receptor 2 binding|phosphatidylinositol 3-kinase binding|protein N-terminus binding|protein phosphatase 2A binding|phosphatidylinositol-4-phosphate binding|14-3-3 protein binding|,10,-1,0.52,10,-1.7,3.97,-1.6,4,0.114,-6.2,1.2
ENSMUSG00000020572,NAMPT,nicotinamide phosphoribosyltransferase,extracellular space|nucleus|cytosol|extracellular vesicular exosome|,vitamin metabolic process|water-soluble vitamin metabolic process|nicotinamide metabolic process|signal transduction|cell-cell signaling|positive regulation of cell proliferation|NAD biosynthetic process|NAD metabolic process|small molecule metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of nitric-oxide synthase biosynthetic process|,nicotinate-nucleotide diphosphorylase (carboxylating) activity|cytokine activity|protein binding|nicotinamide phosphoribosyltransferase activity|,10,2.2,5.14,10,-1.1,0.608,2,4,0.114,-3.1,5.9
ENSMUSG00000003573,HOMER3,homer homolog 3 (Drosophila),cellular_component|cytoplasm|cytosol|plasma membrane|postsynaptic density|cell junction|basal part of cell|postsynaptic membrane|,protein targeting|G-protein coupled glutamate receptor signaling pathway|,protein binding|protein C-terminus binding|protein domain specific binding|,1,5.1,5.32,2,-3.6,2.95,5,4,0.114,-5.5,11
ENSMUSG00000073643,WDFY1,WD repeat and FYVE domain containing 1,nucleus|early endosome|cytosol|,biological_process|,1-phosphatidylinositol binding|zinc ion binding|,0,0,0,1,3.8,4.16,3.8,3.99,0.114,0.2,8
ENSMUSG00000025049,TAF5,"TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa",nucleus|nucleoplasm|transcription factor TFIID complex|actin cytoskeleton|transcription factor TFTC complex|intracellular membrane-bounded organelle|,"DNA-templated transcription, initiation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|chromatin modification|histone acetylation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|histone acetyltransferase activity|protein binding|transcription regulatory region DNA binding|protein dimerization activity|,9,2.4,1.55,9,3.7,2.73,3.1,3.99,0.114,-2.7,9
ENSMUSG00000020705,DDX42,DEAD (Asp-Glu-Ala-Asp) box helicase 42,nucleus|cytoplasm|Cajal body|membrane|nuclear speck|,ATP catabolic process|protein localization|,protein binding|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,1,-4,2.24,1,-3,2.19,-3.7,3.98,0.115,-8,-0.3
ENSMUSG00000034685,FAM171A2,"family with sequence similarity 171, member A2",integral component of membrane|,None,None,0,0,0,1,3.8,4.14,3.8,3.98,0.115,0.2,8
ENSMUSG00000024900,CPT1A,carnitine palmitoyltransferase 1A (liver),mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|membrane|integral component of mitochondrial outer membrane|,long-chain fatty acid metabolic process|glucose metabolic process|fatty acid beta-oxidation|triglyceride metabolic process|carnitine shuttle|carnitine metabolic process|response to organic cyclic compound|epithelial cell differentiation|positive regulation of fatty acid beta-oxidation|response to drug|eating behavior|cellular lipid metabolic process|small molecule metabolic process|regulation of insulin secretion|protein homooligomerization|cellular response to fatty acid|,carnitine O-palmitoyltransferase activity|identical protein binding|,10,0.9,0.96,10,-1.8,4.32,-2,3.97,0.115,-5.1,2.7
ENSMUSG00000037470,UGGT1,UDP-glucose glycoprotein glucosyltransferase 1,endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|extracellular vesicular exosome|,protein folding|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|'de novo' posttranslational protein folding|UDP-glucosylation|,UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding|,10,1.4,0.94,10,2.5,3.41,2.3,3.97,0.115,-7.2,6.2
ENSMUSG00000074734,4933416C03RIK,RIKEN cDNA 4933416C03 gene,cellular_component|,biological_process|,molecular_function|,1,-1,0.413,1,-5,4.25,-4.9,3.96,0.116,-9,-0.4
ENSMUSG00000057637,PRDM2,"PR domain containing 2, with ZNF domain",nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|histone lysine methylation|",DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding|histone-lysine N-methyltransferase activity|,1,-3,1.4,2,-2.9,2.79,-2.9,3.95,0.116,-6,0.1
ENSMUSG00000020513,TUBD1,"tubulin, delta 1",nucleus|cytoplasm|centriole|microtubule|,GTP catabolic process|microtubule-based process|multicellular organismal development|spermatogenesis|cell differentiation|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|GTP binding|,10,-4,3.64,10,-2.2,1.08,-2.4,3.94,0.116,-7.7,1.5
ENSMUSG00000030170,WNT5B,"wingless-type MMTV integration site family, member 5B",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|extracellular vesicular exosome|,chondrocyte differentiation|Wnt signaling pathway|Wnt signaling pathway|neuron differentiation|neuron differentiation|positive regulation of cell migration|wound healing|cell fate commitment|fat cell differentiation|positive regulation of fat cell differentiation|lens fiber cell development|cellular response to retinoic acid|negative regulation of canonical Wnt signaling pathway|,receptor binding|frizzled binding|,9,-2,1.5,10,-1.9,2.7,-1.9,3.94,0.116,-6.8,0.9
ENSMUSG00000056888,GLIPR1,GLI pathogenesis-related 1,extracellular region|plasma membrane|membrane|integral component of membrane|,cellular lipid metabolic process|small molecule metabolic process|,None,1,3.6,4.1,0,0,0,3.6,3.94,0.116,0.1,8
ENSMUSG00000027358,BMP2,bone morphogenetic protein 2,extracellular region|extracellular space|cell surface|,"negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|skeletal system development|osteoblast differentiation|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|epithelial to mesenchymal transition|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|chondrocyte differentiation|BMP signaling pathway involved in heart induction|atrioventricular valve morphogenesis|endocardial cushion morphogenesis|negative regulation of Wnt signaling pathway involved in heart development|proteoglycan metabolic process|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|Notch signaling pathway|cell-cell signaling|heart development|negative regulation of cell proliferation|embryo development|organ morphogenesis|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of steroid biosynthetic process|positive regulation of phosphatase activity|telencephalon development|telencephalon regionalization|positive regulation of Wnt signaling pathway|extracellular matrix organization|bone mineralization|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|BMP signaling pathway|BMP signaling pathway|BMP signaling pathway|protein destabilization|negative regulation of aldosterone biosynthetic process|positive regulation of osteoblast proliferation|cardiocyte differentiation|cardiocyte differentiation|embryonic heart tube anterior/posterior pattern specification|bone mineralization involved in bone maturation|growth|odontogenesis of dentin-containing tooth|positive regulation of odontogenesis|regulation of odontogenesis of dentin-containing tooth|positive regulation of apoptotic process|positive regulation of MAPK cascade|negative regulation of insulin-like growth factor receptor signaling pathway|cell fate commitment|positive regulation of fat cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of astrocyte differentiation|mesenchymal cell differentiation|inner ear development|negative regulation of calcium-independent cell-cell adhesion|cardiac muscle cell differentiation|cardiac muscle tissue morphogenesis|oxidation-reduction process|oxidation-reduction process|pericardium development|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|mesenchyme development|positive regulation of Wnt signaling pathway by BMP signaling pathway|positive regulation of cartilage development|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to organic cyclic compound|cellular response to BMP stimulus|mesenchymal cell proliferation involved in ureteric bud development|negative regulation of canonical Wnt signaling pathway|positive regulation of p38MAPK cascade|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|negative regulation of cortisol biosynthetic process|negative regulation of cardiac muscle cell differentiation|",retinol dehydrogenase activity|receptor binding|cytokine activity|protein binding|growth factor activity|phosphatase activator activity|SMAD binding|protein heterodimerization activity|BMP receptor binding|,10,-3.7,4.79,10,0,0,-3.7,3.94,0.116,-6.9,0.1
ENSMUSG00000034098,FSTL5,follistatin-like 5,extracellular region|,None,calcium ion binding|,10,1.3,0.96,10,-6.1,6.72,-1.3,3.93,0.117,-12,3.9
ENSMUSG00000028936,RPL22,ribosomal protein L22,nucleus|cytoplasm|cytosol|cytosolic large ribosomal subunit|ribonucleoprotein complex|extracellular vesicular exosome|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|cellular protein metabolic process|alpha-beta T cell differentiation|",RNA binding|structural constituent of ribosome|protein binding|heparin binding|poly(A) RNA binding|,10,-1.2,2.4,10,-1.3,1.78,-1.2,3.92,0.117,-4.1,0.3
ENSMUSG00000038650,RNH1,ribonuclease/angiogenin inhibitor 1,cytoplasm|angiogenin-PRI complex|extracellular vesicular exosome|,mRNA catabolic process|negative regulation of catalytic activity|regulation of angiogenesis|,protein binding|ribonuclease inhibitor activity|,10,-4.3,6.23,10,-0.6,0.299,-4.2,3.92,0.117,-10,1.1
ENSMUSG00000015971,ACTR8,ARP8 actin-related protein 8 homolog (yeast),nucleus|Ino80 complex|,"DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|mitotic nuclear division|",protein binding|ATP binding|,10,-1.9,3.84,10,-1.2,0.537,-1.6,3.91,0.118,-6.2,0.5
ENSMUSG00000031447,LAMP1,lysosomal-associated membrane protein 1,cytoplasm|lysosome|lysosome|lysosomal membrane|late endosome|multivesicular body|integral component of plasma membrane|external side of plasma membrane|endosome membrane|membrane|dendrite|sarcolemma|melanosome|neuronal cell body|cytolytic granule|extracellular vesicular exosome|alveolar lamellar body|,autophagy|granzyme-mediated apoptotic signaling pathway|positive regulation of natural killer cell degranulation|positive regulation of natural killer cell mediated cytotoxicity|autophagic cell death|protein stabilization|establishment of protein localization to organelle|Golgi to lysosome transport|regulation of organelle transport along microtubule|,protein binding|enzyme binding|,10,-2.9,4.34,10,-0.8,0.947,-1.8,3.91,0.118,-5.4,0.3
ENSMUSG00000067873,HTATSF1,HIV-1 Tat specific factor 1,nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|viral genome replication|regulation of DNA-templated transcription, elongation|",nucleotide binding|poly(A) RNA binding|,9,5.6,6.22,9,1.1,0.586,5.4,3.91,0.118,-2.9,12.9
ENSMUSG00000027162,LIN7C,lin-7 homolog C (C. elegans),cytoplasm|plasma membrane|cell-cell junction|tight junction|postsynaptic density|basolateral plasma membrane|neuron projection|postsynaptic membrane|extracellular vesicular exosome|MPP7-DLG1-LIN7 complex|,morphogenesis of an epithelial sheet|exocytosis|neurotransmitter secretion|protein transport|,cytoskeletal protein binding|protein domain specific binding|PDZ domain binding|L27 domain binding|,10,2.7,4.08,10,0.9,0.44,2.7,3.9,0.119,-4.5,6.3
ENSMUSG00000030056,ISY1,ISY1 splicing factor homolog (S. cerevisiae),catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|",protein binding|poly(A) RNA binding|,1,3.6,4.06,0,0,0,3.6,3.9,0.119,0.1,8
ENSMUSG00000048391,OLFR843,olfactory receptor 843,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,3.6,4.06,0,0,0,3.6,3.9,0.119,0.1,8
ENSMUSG00000025470,ZFP511,zinc finger protein 511,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",DNA binding|metal ion binding|,0,0,0,1,3.7,4.07,3.7,3.9,0.119,-0.1,7
ENSMUSG00000035172,PLEKHH3,"pleckstrin homology domain containing, family H (with MyTH4 domain) member 3",extracellular space|cytoskeleton|,signal transduction|,None,0,0,0,2,2.6,4.05,2.6,3.89,0.119,-0.5,5
ENSMUSG00000091618,H60C,histocompatibility 60c,anchored component of plasma membrane|,natural killer cell mediated cytotoxicity|,natural killer cell lectin-like receptor binding|,0,0,0,1,3.7,4.05,3.7,3.89,0.119,-0.1,7
ENSMUSG00000024513,MBD2,methyl-CpG binding domain protein 2,histone deacetylase complex|nuclear chromatin|heterochromatin|nucleus|nucleus|cytoplasm|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|positive regulation of Wnt signaling pathway|regulation of cell proliferation|maternal behavior|ATP-dependent chromatin remodeling|cellular protein complex assembly|negative regulation of transcription, DNA-templated|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|satellite DNA binding|mRNA binding|protein binding|methyl-CpG binding|methyl-CpG binding|protein domain specific binding|nucleosomal DNA binding|siRNA binding|C2H2 zinc finger domain binding|,10,1.6,0.895,10,-3.2,4.71,-2.6,3.89,0.119,-7.7,2
ENSMUSG00000048617,RTBDN,retbindin,extracellular region|,None,None,1,-3.3,1.73,1,4.6,4.6,4.5,3.89,0.119,-5.2,9
ENSMUSG00000039239,TGFB2,"transforming growth factor, beta 2",extracellular region|extracellular region|extracellular space|axon|extracellular matrix|platelet alpha granule lumen|neuronal cell body|,cell morphogenesis|cartilage condensation|angiogenesis|eye development|response to hypoxia|epithelial to mesenchymal transition|epithelial to mesenchymal transition|hair follicle development|hair follicle development|blood vessel remodeling|platelet degranulation|heart morphogenesis|protein phosphorylation|cell cycle arrest|transforming growth factor beta receptor signaling pathway|SMAD protein import into nucleus|cell-cell signaling|axon guidance|salivary gland morphogenesis|heart development|blood coagulation|cell death|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|glial cell migration|response to wounding|embryo development|cardioblast differentiation|positive regulation of gene expression|positive regulation of epithelial cell migration|negative regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|negative regulation of macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|cell growth|cell migration|menstrual cycle phase|signal transduction by phosphorylation|hemopoiesis|platelet activation|extracellular matrix organization|collagen fibril organization|positive regulation of cell growth|negative regulation of cell growth|neutrophil chemotaxis|neutrophil chemotaxis|hair follicle morphogenesis|activation of protein kinase activity|response to progesterone|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor beta2 production|positive regulation of cell adhesion mediated by integrin|wound healing|dopamine biosynthetic process|odontogenesis|response to drug|catagen|positive regulation of neuron apoptotic process|cell-cell junction organization|positive regulation of integrin biosynthetic process|positive regulation of ossification|positive regulation of cell cycle|positive regulation of heart contraction|somatic stem cell division|embryonic digestive tract development|neuron fate commitment|neuron development|generation of neurons|negative regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|negative regulation of immune response|positive regulation of immune response|positive regulation of cell division|positive regulation of catagen|positive regulation of cardioblast differentiation|cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|face morphogenesis|pathway-restricted SMAD protein phosphorylation|positive regulation of activation-induced cell death of T cells|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|,beta-amyloid binding|receptor signaling protein serine/threonine kinase activity|receptor binding|type II transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding|cytokine activity|transforming growth factor beta receptor binding|protein binding|protein binding|growth factor activity|protein homodimerization activity|protein heterodimerization activity|,10,-3.4,4.12,10,-1.3,1.3,-3,3.88,0.12,-6.6,5
ENSMUSG00000027641,RBL1,retinoblastoma-like 1,nucleus|nucleoplasm|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|gene expression|viral process|chromatin modification|regulation of lipid kinase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle|",protein binding|transcription factor binding|,10,2.1,4.82,10,0,0,1.9,3.88,0.12,-0.6,5.6
ENSMUSG00000051747,TTN,titin,condensed nuclear chromosome|extracellular region|nucleus|cytoplasm|Golgi apparatus|cytosol|striated muscle thin filament|Z disc|M band|M band|I band|extracellular vesicular exosome|,in utero embryonic development|platelet degranulation|cardiac muscle hypertrophy|muscle contraction|muscle contraction|striated muscle contraction|mitotic chromosome condensation|adult heart development|blood coagulation|peptidyl-tyrosine phosphorylation|muscle filament sliding|platelet activation|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|detection of muscle stretch|forward locomotion|sarcomere organization|regulation of protein kinase activity|cardiac muscle fiber development|sarcomerogenesis|regulation of catalytic activity|response to calcium ion|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|,protease binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|calcium ion binding|protein binding|calmodulin binding|calmodulin binding|ATP binding|structural constituent of muscle|structural constituent of muscle|enzyme binding|protein kinase binding|telethonin binding|telethonin binding|identical protein binding|actinin binding|actinin binding|protein self-association|actin filament binding|muscle alpha-actinin binding|structural molecule activity conferring elasticity|,9,-3.4,1.75,9,-2.6,2.49,-3.2,3.86,0.121,-6.7,0.4
ENSMUSG00000039478,MICU3,"mitochondrial calcium uptake family, member 3",mitochondrion|integral component of membrane|,None,calcium ion binding|,10,2.6,5.79,10,-1.6,1.57,2.4,3.86,0.121,-4.9,6.8
ENSMUSG00000034853,ACOT11,acyl-CoA thioesterase 11,cytoplasm|extracellular vesicular exosome|,fatty acid metabolic process|response to temperature stimulus|response to cold|intracellular signal transduction|,lipid binding|acyl-CoA hydrolase activity|,0,0,0,1,3.7,4.01,3.7,3.85,0.121,-0.2,7
ENSMUSG00000005609,CTR9,"CTR9, Paf1/RNA polymerase II complex component",Cdc73/Paf1 complex|nuclear speck|transcriptionally active chromatin|,"negative regulation of transcription from RNA polymerase II promoter|endodermal cell fate commitment|transcription, DNA-templated|JAK-STAT cascade|histone monoubiquitination|Wnt signaling pathway|stem cell maintenance|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|histone H3-K4 trimethylation|positive regulation of histone H3-K79 methylation|",protein binding|SH2 domain binding|,10,-2.5,1.42,10,-1.7,2.94,-2.1,3.85,0.121,-6.2,0.3
ENSMUSG00000094115,SPIN2-PS6,"spindlin family, member 2, pseudogene 6",None,None,None,2,3.7,4.55,1,-1.9,0.551,3.6,3.85,0.121,-1,8
ENSMUSG00000032555,TOPBP1,topoisomerase (DNA) II binding protein 1,condensed nuclear chromosome|spindle pole|male germ cell nucleus|nucleus|chromosome|cytoplasm|microtubule organizing center|plasma membrane|PML body|,DNA metabolic process|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|,DNA binding|protein binding|protein C-terminus binding|identical protein binding|,8,-2.1,2.31,7,-2.2,1.79,-2.2,3.85,0.121,-6.9,3.1
ENSMUSG00000002814,TOP3A,topoisomerase (DNA) III alpha,nucleus|chromosome|PML body|,DNA topological change|meiotic nuclear division|,DNA binding|DNA topoisomerase type I activity|protein binding|zinc ion binding|,10,-0.1,0.00602,10,-2.4,5.11,-2.1,3.85,0.121,-7.1,0.8
ENSMUSG00000023034,NR4A1,"nuclear receptor subfamily 4, group A, member 1",nucleus|nucleoplasm|transcription factor complex|cytoplasm|,positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|transcription initiation from RNA polymerase II promoter|signal transduction|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|gene expression|intracellular receptor signaling pathway|intracellular receptor signaling pathway|endothelial cell chemotaxis|skeletal muscle cell differentiation|cellular response to vascular endothelial growth factor stimulus|Fc-epsilon receptor signaling pathway|positive regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|steroid hormone mediated signaling pathway|cellular response to fibroblast growth factor stimulus|innate immune response|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|,RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|protein homodimerization activity|sequence-specific DNA binding|protein heterodimerization activity|,1,0,0,1,4.4,4.56,4.4,3.85,0.121,0.3,9
ENSMUSG00000031095,CUL4B,cullin 4B,nucleus|cytoplasm|plasma membrane|Cul4B-RING E3 ubiquitin ligase complex|extracellular vesicular exosome|,ubiquitin-dependent protein catabolic process|cell cycle|histone H2A monoubiquitination|positive regulation of protein catabolic process|UV-damage excision repair|positive regulation of G1/S transition of mitotic cell cycle|,damaged DNA binding|protein binding|ubiquitin protein ligase binding|,9,-0.9,0.474,10,-2.1,4.07,-1.6,3.85,0.121,-5.5,0.9
ENSMUSG00000004951,HSPB1,heat shock 27kDa protein 1,proteasome complex|extracellular space|nucleus|cytoplasm|cytoplasm|spindle|cytosol|cytoskeleton|plasma membrane|Z disc|extracellular vesicular exosome|,retina homeostasis|regulation of translational initiation|negative regulation of protein kinase activity|cellular component movement|response to unfolded protein|cell death|response to virus|gene expression|RNA metabolic process|mRNA metabolic process|positive regulation of interleukin-1 beta production|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of tumor necrosis factor biosynthetic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|negative regulation of protein serine/threonine kinase activity|negative regulation of protein serine/threonine kinase activity|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of endothelial cell chemotaxis|,protein kinase C binding|protein binding|protein kinase C inhibitor activity|protein kinase binding|identical protein binding|ubiquitin binding|poly(A) RNA binding|,9,-3,2.9,10,-1.6,1.9,-2.6,3.84,0.122,-8,2
ENSMUSG00000005161,PRDX2,peroxiredoxin 2,cytoplasm|cytosol|extracellular vesicular exosome|,response to oxidative stress|response to oxidative stress|removal of superoxide radicals|cellular response to oxidative stress|hydrogen peroxide catabolic process|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|oxidation-reduction process|,thioredoxin peroxidase activity|thioredoxin peroxidase activity|antioxidant activity|antioxidant activity|,10,-3.7,5.63,9,0,0,-2.6,3.84,0.122,-8.3,0.8
ENSMUSG00000048537,PHLDB1,"pleckstrin homology-like domain, family B, member 1",None,None,None,1,-2.6,1.09,2,2.9,4.41,2.8,3.83,0.122,-3.3,6
ENSMUSG00000064289,TANK,TRAF family member-associated NFKB activator,cytoplasm|cytosol|,signal transduction|I-kappaB kinase/NF-kappaB signaling|innate immune response|,protein binding|ubiquitin protein ligase binding|metal ion binding|,9,-1.2,1.55,9,-3.6,3.76,-2.9,3.83,0.122,-8.2,5
ENSMUSG00000054203,IFI205,interferon activated gene 205,nucleus|nucleolus|cytoplasm|membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to interferon-beta|",double-stranded DNA binding|double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,10,7,6.18,10,-3.1,1.35,-4.2,3.82,0.123,-9.4,13.4
ENSMUSG00000029617,CCZ1,CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae),lysosomal membrane|,None,None,9,-2.4,0.738,9,-2.1,3.35,-2.2,3.82,0.123,-5.5,2.9
ENSMUSG00000026313,HDAC4,histone deacetylase 4,histone deacetylase complex|nucleus|cytoplasm|cytosol|transcriptional repressor complex|Z disc|neuromuscular junction|A band|actomyosin|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|osteoblast development|chromatin remodeling|transcription, DNA-templated|inflammatory response|nervous system development|positive regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of myotube differentiation|regulation of cardiac muscle contraction by calcium ion signaling|response to denervation involved in regulation of muscle adaptation|cardiac muscle hypertrophy in response to stress|histone deacetylation|histone deacetylation|B cell differentiation|positive regulation of protein sumoylation|peptidyl-lysine deacetylation|B cell activation|response to drug|regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of osteoblast differentiation|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of skeletal muscle fiber development|positive regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-1|histone H3 deacetylation|histone H4 deacetylation|",core promoter binding|transcription corepressor activity|histone deacetylase activity|protein binding|transcription factor binding|zinc ion binding|protein kinase binding|potassium ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|activating transcription factor binding|histone deacetylase binding|sequence-specific DNA binding|transcription regulatory region DNA binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|repressing transcription factor binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,1.4,0.654,10,4.8,4.64,3,3.82,0.123,-3.2,10.7
ENSMUSG00000067006,SERPINB5,"serpin peptidase inhibitor, clade B (ovalbumin), member 5",extracellular space|cytoplasm|extracellular vesicular exosome|,morphogenesis of an epithelium|cellular component movement|negative regulation of endopeptidase activity|regulation of proteolysis|extracellular matrix organization|regulation of epithelial cell proliferation|prostate gland morphogenesis|,serine-type endopeptidase inhibitor activity|protein binding|,1,3.8,4.53,1,-1.6,0.356,3.7,3.82,0.123,-1.1,8
ENSMUSG00000031756,CENPN,centromere protein N,condensed chromosome kinetochore|nucleus|nucleoplasm|cytosol|,mitotic cell cycle|nucleosome assembly|chromosome segregation|mitotic nuclear division|centromere-specific nucleosome assembly|,None,8,-2.6,1.23,9,-1.8,3.15,-2,3.81,0.123,-7,2.1
ENSMUSG00000090662,VMN2R45,"vomeronasal 2, receptor 45",cellular_component|plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|biological_process|,molecular_function|signal transducer activity|G-protein coupled receptor activity|,3,-3.4,2.36,2,5.6,5.42,5.5,3.81,0.123,-4.8,11
ENSMUSG00000027306,NUSAP1,nucleolar and spindle associated protein 1,nucleus|chromosome|nucleolus|cytoplasm|spindle microtubule|,mitotic sister chromatid segregation|mitotic cytokinesis|mitotic chromosome condensation|establishment of mitotic spindle localization|positive regulation of mitosis|,DNA binding|microtubule binding|poly(A) RNA binding|,10,-1.6,2.56,10,-2.6,1.96,-2.3,3.81,0.123,-6.9,1.2
ENSMUSG00000040966,SLC22A2,"solute carrier family 22 (organic cation transporter), member 2",plasma membrane|integral component of plasma membrane|membrane|basolateral plasma membrane|extracellular vesicular exosome|,drug transmembrane transport|synaptic transmission|neurotransmitter secretion|body fluid secretion|organic cation transport|quaternary ammonium group transport|choline transport|ion transmembrane transport|neurotransmitter biosynthetic process|small molecule metabolic process|histamine transport|transmembrane transport|,steroid binding|organic cation transmembrane transporter activity|choline transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|,1,3.5,3.97,0,0,0,3.5,3.81,0.123,0,8
ENSMUSG00000058254,TSPAN7,tetraspanin 7,integral component of plasma membrane|,viral process|,None,10,-1.6,3.93,10,-0.7,0.241,-1.5,3.8,0.124,-12.9,1.1
ENSMUSG00000033726,EMX1,empty spiracles homeobox 1,nucleus|cytoplasm|,"regulation of transcription, DNA-templated|post-embryonic development|cerebral cortex regionalization|cerebral cortex neuron differentiation|response to drug|brain morphogenesis|",sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,1,3.5,3.96,0,0,0,3.5,3.8,0.124,0,8
ENSMUSG00000034023,FANCD2,"Fanconi anemia, complementation group D2",condensed chromosome|nucleus|nucleoplasm|Golgi apparatus|intracellular membrane-bounded organelle|,DNA repair|synapsis|gamete generation|response to gamma radiation|,protein binding|DNA polymerase binding|,9,-6.9,3.71,10,-1.6,2.55,-1.4,3.8,0.124,-12.2,1.3
ENSMUSG00000037820,TGM2,transglutaminase 2,mitochondrion|cytosol|plasma membrane|extracellular vesicular exosome|,blood vessel remodeling|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|apoptotic cell clearance|positive regulation of cell adhesion|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|protein homooligomerization|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of mitochondrial calcium ion concentration|branching involved in salivary gland morphogenesis|salivary gland cavitation|,protein-glutamine gamma-glutamyltransferase activity|protein-glutamine gamma-glutamyltransferase activity|protein binding|GTP binding|protein domain specific binding|metal ion binding|,10,-2.8,5.14,10,-0.4,0.133,-2.6,3.8,0.124,-6.5,0.4
ENSMUSG00000071078,NR2C2AP,nuclear receptor 2C2-associated protein,nucleoplasm|extracellular vesicular exosome|,transcription initiation from RNA polymerase II promoter|cell adhesion|gene expression|,protein binding|,10,-2.9,3.54,10,2.3,3.56,-2.7,3.8,0.124,-6.7,4.3
ENSMUSG00000025280,POLR3A,"polymerase (RNA) III (DNA directed) polypeptide A, 155kDa",nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|membrane|,"transcription, DNA-templated|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|innate immune response|defense response to virus|",RNA polymerase III activity|DNA binding|chromatin binding|DNA-directed RNA polymerase activity|zinc ion binding|ribonucleoside binding|,3,2.1,1.12,5,5.5,4.04,5.3,3.8,0.124,-3.6,11
ENSMUSG00000006378,GCAT,glycine C-acetyltransferase,nucleus|mitochondrion|,cellular amino acid metabolic process|biosynthetic process|L-threonine catabolic process to glycine|,glycine C-acetyltransferase activity|pyridoxal phosphate binding|,1,-2.8,1.18,1,-3.3,2.9,-3.2,3.79,0.124,-6,0.3
ENSMUSG00000029084,CD38,CD38 molecule,nucleus|plasma membrane|cell surface|membrane|integral component of membrane|,"response to hypoxia|signal transduction|positive regulation of cytosolic calcium ion concentration|female pregnancy|metabolic process|positive regulation of cell growth|positive regulation of B cell proliferation|positive regulation of insulin secretion|response to estradiol|response to retinoic acid|response to progesterone|response to hydroperoxide|response to drug|negative regulation of apoptotic process|negative regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|B cell receptor signaling pathway|long term synaptic depression|response to interleukin-1|apoptotic signaling pathway|",NAD+ nucleosidase activity|transferase activity|phosphorus-oxygen lyase activity|NAD(P)+ nucleosidase activity|,10,-4.5,4.1,10,-1.8,0.271,-2.5,3.79,0.124,-8.1,0.7
ENSMUSG00000025268,MAGED2,"melanoma antigen family D, 2",membrane|,None,None,2,-3.8,3.94,0,0,0,-3.8,3.78,0.125,-8,0
ENSMUSG00000020061,MYBPC1,"myosin binding protein C, slow type",cytosol|myofibril|myosin filament|,cell adhesion|muscle filament sliding|,actin binding|protein binding|structural constituent of muscle|titin binding|,0,0,0,1,3.6,3.95,3.6,3.78,0.125,-0.2,7
ENSMUSG00000064080,FBLN2,fibulin 2,extracellular region|proteinaceous extracellular matrix|extracellular matrix|extracellular vesicular exosome|,positive regulation of cell-substrate adhesion|extracellular matrix organization|,extracellular matrix structural constituent|calcium ion binding|extracellular matrix binding|,1,2,1.44,1,3.1,2.82,3,3.78,0.125,-0.3,6
ENSMUSG00000038347,TCTE2,t-complex-associated testis expressed 2,cellular_component|,biological_process|,molecular_function|,10,0,0,10,-3.2,5.36,-1.1,3.78,0.125,-8.6,0.1
ENSMUSG00000025159,MMS19,MMS19 nucleotide excision repair homolog (S. cerevisiae),nucleus|nucleus|holo TFIIH complex|cytoplasm|spindle|membrane|MMXD complex|CIA complex|,"phosphorelay signal transduction system|DNA metabolic process|DNA repair|nucleotide-excision repair|nucleotide-excision repair|transcription, DNA-templated|cellular response to DNA damage stimulus|chromosome segregation|response to hormone|iron-sulfur cluster assembly|small molecule metabolic process|positive regulation of transcription, DNA-templated|","transcription coactivator activity|protein binding|receptor signaling complex scaffold activity|estrogen receptor binding|protein binding, bridging|",9,-0.5,0.277,10,-2.6,4.46,-1.7,3.78,0.125,-4.9,0.2
ENSMUSG00000014859,E2F4,"E2F transcription factor 4, p107/p130-binding",nucleus|nucleoplasm|transcription factor complex|cytoplasm|,"regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|epithelial cell development|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|cell volume homeostasis|transforming growth factor beta receptor signaling pathway|blood circulation|regulation of cell size|organ morphogenesis|gene expression|regulation of cell proliferation|cilium assembly|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein domain specific binding|,10,-1.5,1.83,10,-0.9,2.55,-1.1,3.77,0.126,-7.6,0.5
ENSMUSG00000029863,CASP2,"caspase 2, apoptosis-related cysteine peptidase",nucleus|cytoplasm|mitochondrion|cytosol|membrane|,"luteolysis|neural retina development|proteolysis|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|brain development|aging|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to DNA damage|protein processing|ectopic germ cell programmed cell death|positive regulation of apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|neurotrophin TRK receptor signaling pathway|cellular response to mechanical stimulus|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|positive regulation of apoptotic signaling pathway|",cysteine-type endopeptidase activity|protein binding|enzyme binding|protein domain specific binding|cysteine-type endopeptidase activity involved in apoptotic process|,0,0,0,1,3.6,3.93,3.6,3.77,0.126,-0.2,7
ENSMUSG00000062376,2010012O05RIK,RIKEN cDNA 2010012O05 gene,cellular_component|,biological_process|,molecular_function|,1,3.5,3.93,0,0,0,3.5,3.77,0.126,0,8
ENSMUSG00000037935,SMARCE1,"SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1",nuclear chromosome|nuclear chromatin|nucleus|SWI/SNF complex|transcriptional repressor complex|protein complex|npBAF complex|nBAF complex|,"nucleosome disassembly|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|nervous system development|metabolic process|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|chromatin binding|transcription coactivator activity|RNA binding|protein binding|N-acetyltransferase activity|ligand-dependent nuclear receptor binding|nucleosomal DNA binding|protein N-terminus binding|,0,0,0,3,2.5,3.92,2.5,3.76,0.126,-0.5,5
ENSMUSG00000015854,CD5L,CD5 molecule-like,extracellular region|extracellular space|membrane|extracellular vesicular exosome|blood microparticle|,receptor-mediated endocytosis|apoptotic process|cellular defense response|,scavenger receptor activity|,10,-1,1.21,10,-3.1,3.56,-1.1,3.76,0.126,-8,2.7
ENSMUSG00000032782,CNTROB,"centrobin, centrosomal BRCA2 interacting protein",cytoplasm|centrosome|centriole|,cytokinesis|centriole replication|centrosome separation|,protein binding|protein domain specific binding|,9,-1.5,2.59,9,-1.3,1.45,-1.4,3.76,0.126,-5.6,4.1
ENSMUSG00000032855,PKD1,polycystic kidney disease 1 (autosomal dominant),polycystin complex|nucleus|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|integral component of membrane|basolateral plasma membrane|lateral plasma membrane|motile primary cilium|extracellular vesicular exosome|,cartilage condensation|in utero embryonic development|kidney development|liver development|embryonic placenta development|protein export from nucleus|nitrogen compound metabolic process|cell cycle arrest|homophilic cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|JAK-STAT cascade|heart development|anatomical structure morphogenesis|peptidyl-serine phosphorylation|spinal cord development|neural tube development|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|positive regulation of protein binding|cytoplasmic sequestering of transcription factor|skin development|positive regulation of transcription from RNA polymerase II promoter|digestive tract development|branching morphogenesis of an epithelial tube|genitalia development|detection of mechanical stimulus|detection of mechanical stimulus|cartilage development|regulation of mitotic spindle organization|lung epithelium development|placenta blood vessel development|regulation of proteasomal protein catabolic process|calcium ion transmembrane transport|mesonephric tubule development|mesonephric duct development|metanephric collecting duct development|metanephric ascending thin limb development|metanephric proximal tubule development|metanephric distal tubule morphogenesis|,cation channel activity|calcium channel activity|protein binding|protein kinase binding|protein domain specific binding|carbohydrate binding|ion channel binding|,10,-1,1.32,10,-3.2,3.39,-2.6,3.75,0.127,-7.4,1
ENSMUSG00000020402,VDAC1,voltage-dependent anion channel 1,nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|membrane|mitochondrial nucleoid|pore complex|extracellular vesicular exosome|,behavioral fear response|anion transport|apoptotic process|neuron-neuron synaptic transmission|learning|viral process|epithelial cell differentiation|regulation of anion transport|transmembrane transport|,protein binding|voltage-gated anion channel activity|voltage-gated anion channel activity|porin activity|,10,-2.1,1.8,10,-1.6,2.32,-1.9,3.75,0.127,-5.7,0.8
ENSMUSG00000022895,ETS2,v-ets avian erythroblastosis virus E26 oncogene homolog 2,nucleus|nucleoplasm|,"negative regulation of transcription from RNA polymerase II promoter|skeletal system development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|glucocorticoid receptor binding|,10,5.6,3.05,9,1.8,2.98,1.3,3.75,0.127,-4.2,11.3
ENSMUSG00000047751,UTF1,undifferentiated embryonic cell transcription factor 1,nucleus|nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|male gonad development|positive regulation of transcription from RNA polymerase II promoter|",transcription coactivator activity|protein binding|HMG box domain binding|,10,2.8,2.31,10,-1.9,2.35,-2.3,3.74,0.127,-6.7,5.9
ENSMUSG00000079553,KIFC1,kinesin family member C1,nucleus|early endosome|microtubule organizing center|spindle|kinesin complex|microtubule|membrane|,mitotic sister chromatid segregation|microtubule-based movement|blood coagulation|metabolic process|metabolic process|,microtubule motor activity|ATP binding|microtubule binding|,9,-1.6,2.11,9,-2.4,2.17,-2,3.74,0.127,-8,3.7
ENSMUSG00000034021,PDS5B,"PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)","chromosome, centromeric region|chromatin|nucleus|nucleus|nucleoplasm|chromosome|cytosol|",mitotic cell cycle|mitotic sister chromatid cohesion|cell proliferation|negative regulation of cell proliferation|regulation of cell proliferation|,DNA binding|protein binding|ATP binding|,10,1.9,2.19,10,-2.5,4.27,-2.3,3.73,0.128,-6.8,3.1
ENSMUSG00000039976,TBC1D16,"TBC1 domain family, member 16",None,positive regulation of Rab GTPase activity|,Rab GTPase activator activity|,0,0,0,1,3.6,3.89,3.6,3.73,0.128,-0.2,7
ENSMUSG00000024258,POLR2D,polymerase (RNA) II (DNA directed) polypeptide D,"cytoplasmic mRNA processing body|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|","nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA splicing|gene expression|viral process|mRNA export from nucleus in response to heat stress|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of translational initiation|positive regulation of viral transcription|",nucleotide binding|single-stranded DNA binding|single-stranded RNA binding|DNA-directed RNA polymerase activity|translation initiation factor binding|,8,4.2,5.6,7,-2.1,1.24,-3,3.73,0.128,-6,8.1
ENSMUSG00000010660,PLCD1,"phospholipase C, delta 1",cytoplasm|cytosol|plasma membrane|extracellular vesicular exosome|,angiogenesis|phospholipid metabolic process|lipid catabolic process|intracellular signal transduction|regulation of cell proliferation|inositol phosphate metabolic process|small molecule metabolic process|labyrinthine layer blood vessel development|,phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|GTPase activating protein binding|,10,-1.9,2.06,10,-1.5,2.04,-1.7,3.73,0.128,-7.6,3.8
ENSMUSG00000001552,JUP,junction plakoglobin,nucleus|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|plasma membrane|cell-cell junction|cell-cell adherens junction|zonula adherens|zonula adherens|fascia adherens|cytoplasmic side of plasma membrane|cytoplasmic side of plasma membrane|intercalated disc|actin cytoskeleton|basolateral plasma membrane|apicolateral plasma membrane|lateral plasma membrane|catenin complex|Z disc|desmosome|protein-DNA complex|extracellular vesicular exosome|gamma-catenin-TCF7L2 complex|,cell morphogenesis|desmosome assembly|desmosome assembly|negative regulation of heart induction by canonical Wnt signaling pathway|atrioventricular valve morphogenesis|negative regulation of Wnt signaling pathway involved in heart development|cytoskeletal anchoring at plasma membrane|cytoskeletal anchoring at plasma membrane|gastrulation|ectoderm development|nervous system development|morphogenesis of embryonic epithelium|single organismal cell-cell adhesion|single organismal cell-cell adhesion|cell migration|cell junction assembly|adherens junction organization|regulation of cell proliferation|positive regulation of protein import into nucleus|skin development|cell-cell junction organization|oocyte development|detection of mechanical stimulus|positive regulation of sequence-specific DNA binding transcription factor activity|protein heterooligomerization|endothelial cell-cell adhesion|cellular response to indole-3-methanol|ventricular cardiac muscle cell action potential|bundle of His cell to Purkinje myocyte communication|regulation of heart rate by cardiac conduction|establishment of protein localization to plasma membrane|positive regulation of canonical Wnt signaling pathway|,transcription coactivator activity|structural molecule activity|structural molecule activity|structural constituent of cell wall|protein binding|protein kinase binding|protein phosphatase binding|protein homodimerization activity|alpha-catenin binding|cadherin binding|,10,2.8,2.15,10,1.8,2.01,1.9,3.73,0.128,-3.2,6.8
ENSMUSG00000020739,NUP85,nucleoporin 85kDa,kinetochore|condensed chromosome kinetochore|nuclear envelope|spindle|cytosol|membrane|nuclear pore outer ring|nuclear pore outer ring|nuclear membrane|,mitotic cell cycle|carbohydrate metabolic process|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|lamellipodium assembly|small molecule metabolic process|macrophage chemotaxis|mRNA transport|transmembrane transport|,protein binding|,5,3.4,2.09,6,-2.9,3.43,-3.1,3.72,0.129,-8,4.7
ENSMUSG00000020697,LIG3,"ligase III, DNA, ATP-dependent",synaptonemal complex|nucleus|nucleoplasm|chromosome|,"lagging strand elongation|DNA repair|base-excision repair|base-excision repair, DNA ligation|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|reciprocal meiotic recombination|spermatogenesis|mitochondrial DNA repair|negative regulation of DNA recombination|",DNA binding|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|zinc ion binding|,9,-3.4,6.02,10,0.3,0.0686,-3,3.72,0.129,-9.5,0.8
ENSMUSG00000021965,SKA3,spindle and kinetochore associated complex subunit 3,condensed chromosome outer kinetochore|cytoplasm|spindle microtubule|,chromosome segregation|mitotic nuclear division|regulation of microtubule polymerization or depolymerization|,protein binding|,7,-0.2,0.00412,9,-3.2,4.97,-3,3.72,0.129,-7.2,0.8
ENSMUSG00000036968,CNPY4,canopy FGF signaling regulator 4,extracellular region|,None,receptor binding|,10,2.5,5.17,10,-0.2,0.0521,2.2,3.71,0.129,-2.4,7.5
ENSMUSG00000051786,TUBGCP6,"tubulin, gamma complex associated protein 6",spindle pole|centrosome|cytosol|microtubule|gamma-tubulin ring complex|membrane|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|microtubule nucleation|,microtubule binding|,9,3.7,0.372,10,2.2,4.02,2.3,3.71,0.129,-2.2,7.1
ENSMUSG00000079655,GM5168,predicted gene 5168,cellular_component|,biological_process|,molecular_function|,3,-4.9,4.75,3,1.8,0.281,-4.7,3.7,0.13,-10,0.9
ENSMUSG00000030199,ETV6,ets variant 6,nucleolus|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell differentiation|,RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity|protein binding|protein domain specific binding|,10,-1.5,3.65,10,-0.9,0.502,-1.4,3.68,0.131,-11.5,3.9
ENSMUSG00000036241,UBE2R2,ubiquitin-conjugating enzyme E2R 2,None,protein monoubiquitination|protein K48-linked ubiquitination|,ubiquitin-protein transferase activity|ATP binding|acid-amino acid ligase activity|,10,-2.7,3.44,10,-0.9,1.37,-2.1,3.68,0.131,-6.7,0.7
ENSMUSG00000036712,CYLD,cylindromatosis (turban tumor syndrome),nucleus|centrosome|cytosol|cytosol|cytoplasmic microtubule|midbody|extrinsic component of cytoplasmic side of plasma membrane|perinuclear region of cytoplasm|,"ubiquitin-dependent protein catabolic process|cell cycle|regulation of mitotic cell cycle|Wnt signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|innate immune response|necroptotic process|nucleotide-binding oligomerization domain containing signaling pathway|regulation of microtubule cytoskeleton organization|protein K63-linked deubiquitination|negative regulation of canonical Wnt signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|",ubiquitin-specific protease activity|protein binding|zinc ion binding|protein kinase binding|Lys63-specific deubiquitinase activity|proline-rich region binding|,10,-1.4,3.61,10,-0.8,0.393,-1.4,3.67,0.132,-4.9,0.5
ENSMUSG00000031144,SYP,synaptophysin,cell junction|integral component of synaptic vesicle membrane|presynaptic membrane|neuron projection|protein complex|neuron projection terminus|presynaptic active zone|excitatory synapse|,endocytosis|synaptic vesicle maturation|regulation of neuronal synaptic plasticity|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle membrane organization|cellular response to organic substance|regulation of opioid receptor signaling pathway|,transporter activity|cholesterol binding|syntaxin-1 binding|protein complex binding|SH2 domain binding|identical protein binding|,1,3.7,4.37,1,-0.8,0.104,3.7,3.67,0.132,-0.2,8
ENSMUSG00000049807,ARHGAP23,Rho GTPase activating protein 23,cytosol|extracellular vesicular exosome|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,0,0,0,1,3.6,3.83,3.6,3.67,0.132,-0.3,7
ENSMUSG00000034168,IRF2BPL,interferon regulatory factor 2 binding protein-like,extracellular space|nucleus|nucleus|,negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|development of secondary female sexual characteristics|,molecular_function|metal ion binding|,10,-2.2,3.58,10,-1.7,0.409,-2.1,3.66,0.132,-7,1.1
ENSMUSG00000027342,PCNA,proliferating cell nuclear antigen,nucleus|nucleoplasm|DNA replication factor C complex|cytoplasm|centrosome|nuclear replication fork|PCNA complex|extracellular vesicular exosome|PCNA-p21 complex|,"G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA strand elongation involved in DNA replication|leading strand elongation|regulation of DNA replication|DNA repair|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|heart development|cell proliferation|translesion synthesis|epithelial cell differentiation|positive regulation of deoxyribonuclease activity|telomere maintenance via semi-conservative replication|response to lipid|response to cadmium ion|phosphatidylinositol-mediated signaling|",purine-specific mismatch base pair DNA N-glycosylase activity|protein binding|DNA polymerase processivity factor activity|receptor tyrosine kinase binding|dinucleotide insertion or deletion binding|MutLalpha complex binding|identical protein binding|DNA polymerase binding|,3,-3.9,1.23,4,-2.4,2.79,-3.7,3.66,0.132,-8,0.3
ENSMUSG00000031016,WEE1,WEE1 G2 checkpoint kinase,nucleus|nucleoplasm|cytoplasm|,G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|mitotic nuclear division|blood coagulation|peptidyl-tyrosine phosphorylation|establishment of cell polarity|neuron projection morphogenesis|regulation of cell cycle|,magnesium ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|,9,3.3,5.58,8,0.3,0.00811,2.7,3.66,0.132,-1.4,8.3
ENSMUSG00000029201,UGDH,UDP-glucose 6-dehydrogenase,nucleus|cytosol|,gastrulation with mouth forming second|UDP-glucose metabolic process|glycosaminoglycan biosynthetic process|UDP-glucuronate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process|small molecule metabolic process|cellular glucuronidation|oxidation-reduction process|,UDP-glucose 6-dehydrogenase activity|electron carrier activity|NAD binding|,10,-1.3,2.14,9,-1.7,1.85,-1.5,3.66,0.132,-4.8,1.4
ENSMUSG00000021998,LCP1,lymphocyte cytosolic protein 1 (L-plastin),stress fiber|ruffle|phagocytic cup|extracellular space|cytoplasm|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|actin cytoskeleton|filopodium|actin filament bundle|ruffle membrane|extracellular vesicular exosome|,T cell activation involved in immune response|protein kinase A signaling|cell migration|organ regeneration|regulation of intracellular protein transport|actin filament bundle assembly|,actin binding|calcium ion binding|identical protein binding|actin filament binding|,10,-3.2,3.46,9,1.2,1.07,-2.1,3.66,0.132,-8,7.6
ENSMUSG00000020638,CMPK2,"cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial",nucleus|mitochondrion|,nucleoside diphosphate phosphorylation|dUDP biosynthetic process|dTDP biosynthetic process|nucleoside triphosphate biosynthetic process|cellular response to lipopolysaccharide|,cytidylate kinase activity|nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|UMP kinase activity|,9,1.5,3.78,9,-1,0.308,1.4,3.65,0.133,-2.7,4.9
ENSMUSG00000033392,CLASP2,cytoplasmic linker associated protein 2,condensed chromosome kinetochore|cytoplasm|Golgi apparatus|trans-Golgi network|microtubule organizing center|kinetochore microtubule|cytosol|microtubule|cytoplasmic microtubule|plasma membrane|cell cortex|membrane|ruffle membrane|,mitotic cell cycle|microtubule nucleation|negative regulation of microtubule depolymerization|mitotic nuclear division|establishment or maintenance of cell polarity|axon guidance|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|regulation of microtubule-based process|microtubule anchoring|fucosylation|,protein binding|galactoside 2-alpha-L-fucosyltransferase activity|microtubule plus-end binding|,10,-3.4,1.88,9,-1.5,2.22,-1.7,3.65,0.133,-9.6,5.8
ENSMUSG00000073490,AI607873,expressed sequence AI607873,nucleus|nucleolus|cytoplasm|membrane|,biological_process|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,9,-3.9,1.08,8,-1.6,3.31,-1.6,3.64,0.134,-6.8,0.9
ENSMUSG00000068551,ZFP467,zinc finger protein 467,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",nucleic acid binding|DNA binding|protein binding|metal ion binding|,2,-2.9,0.891,1,-4.4,3.29,-4.3,3.63,0.134,-8,0
ENSMUSG00000015656,HSPA8,heat shock 70kDa protein 8,Prp19 complex|extracellular space|intracellular|nucleus|spliceosomal complex|nucleolus|cytosol|cytosol|plasma membrane|membrane|ribonucleoprotein complex|melanosome|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|extracellular vesicular exosome|blood microparticle|,"ATP catabolic process|transcription, DNA-templated|mRNA processing|protein folding|post-Golgi vesicle-mediated transport|response to unfolded protein|synaptic transmission|neurotransmitter secretion|axon guidance|RNA splicing|gene expression|viral process|RNA metabolic process|mRNA metabolic process|protein refolding|negative regulation of transcription, DNA-templated|chaperone mediated protein folding requiring cofactor|regulation of cell cycle|membrane organization|negative regulation of fibril organization|","protein binding|ATP binding|ATPase activity|enzyme binding|MHC class II protein complex binding|heat shock protein binding|ATPase activity, coupled|poly(A) RNA binding|unfolded protein binding|",4,2.2,1.03,5,2.5,2.83,2.4,3.62,0.135,-0.5,6
ENSMUSG00000056459,ZBTB25,zinc finger and BTB domain containing 25,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|gene expression|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|metal ion binding|,2,-4.2,4.18,1,-0.7,0.0875,-4.1,3.62,0.135,-9,-0.1
ENSMUSG00000034509,MAD2L1BP,MAD2L1 binding protein,nucleus|nucleolus|cytoplasm|spindle|intracellular membrane-bounded organelle|,mitotic cell cycle checkpoint|regulation of exit from mitosis|,protein binding|,10,0,0,10,-2.4,5.71,-2.1,3.61,0.135,-7.2,0.9
ENSMUSG00000028582,CC2D1B,coiled-coil and C2 domain containing 1B,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|,0,0,0,1,3.5,3.77,3.5,3.61,0.135,-0.3,7
ENSMUSG00000050377,IL31RA,interleukin 31 receptor A,plasma membrane|integral component of membrane|,"MAPK cascade|defense response|transmembrane receptor protein tyrosine kinase signaling pathway|JAK-STAT cascade|positive regulation of cell proliferation|cytokine-mediated signaling pathway|monocyte differentiation|macrophage differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|homeostatic process|negative regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|",transcription coactivator activity|cytokine receptor activity|protein kinase binding|cytokine binding|,9,2.4,2.57,10,-1.9,3.41,-1.9,3.6,0.136,-5.5,3.8
ENSMUSG00000072770,ACRBP,acrosin binding protein,acrosomal vesicle|extracellular region|nucleus|,biological_process|,molecular_function|,0,0,0,1,3.5,3.75,3.5,3.59,0.137,-0.3,7
ENSMUSG00000042489,CLSPN,claspin,nucleoplasm|,DNA damage checkpoint|DNA replication|DNA repair|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|peptidyl-serine phosphorylation|G2 DNA damage checkpoint|activation of protein kinase activity|mitotic DNA replication checkpoint|,DNA binding|protein binding|anaphase-promoting complex binding|,8,-2.9,3.13,8,-1.9,1.05,-2.6,3.59,0.137,-6.2,0.7
ENSMUSG00000005610,EIF4G2,"eukaryotic translation initiation factor 4 gamma, 2",cytosol|membrane|eukaryotic translation initiation factor 4F complex|,translational initiation|regulation of translational initiation|cell cycle arrest|cell death|cytokine-mediated signaling pathway|,"translation initiation factor activity|protein binding|translation factor activity, nucleic acid binding|poly(A) RNA binding|",8,-6.1,2.9,10,1.8,1.53,-1.2,3.58,0.137,-10.3,3.9
ENSMUSG00000015947,FCGR1,"Fc receptor, IgG, high affinity I",plasma membrane|external side of plasma membrane|membrane|integral component of membrane|,"antibody-dependent cellular cytotoxicity|positive regulation of type IIa hypersensitivity|positive regulation of type III hypersensitivity|immune system process|receptor-mediated endocytosis|phagocytosis, recognition|phagocytosis, engulfment|cell surface receptor signaling pathway|response to bacterium|antigen processing and presentation of exogenous antigen|Fc-gamma receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|defense response to bacterium|innate immune response|positive regulation of phagocytosis|regulation of immune response|",IgG receptor activity|IgG binding|IgG binding|,10,-4.1,4.87,10,1.7,3.39,-2.1,3.58,0.137,-9.9,3.3
ENSMUSG00000038524,FCHSD1,FCH and double SH3 domains 1,None,None,None,0,0,0,1,-4.8,3.74,-4.8,3.58,0.137,-9,0
ENSMUSG00000000355,MCTS1,malignant T cell amplified sequence 1,cytoplasm|plasma membrane|cytosolic small ribosomal subunit|,"formation of translation preinitiation complex|IRES-dependent translational initiation|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|cell cycle|positive regulation of cell proliferation|ribosome disassembly|regulation of growth|",RNA binding|,9,6.1,4.76,10,1.2,0.403,5.8,3.58,0.137,-0.6,12.8
ENSMUSG00000040631,DOK4,docking protein 4,None,MAPK cascade|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|,receptor signaling protein activity|insulin receptor binding|protein binding|,0,0,0,2,2.5,3.73,2.5,3.57,0.138,-0.7,5
ENSMUSG00000013629,CAD,"carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase",nucleus|cytosol|cytosol|membrane|nuclear matrix|cell projection|neuronal cell body|terminal bouton|protein complex|extracellular vesicular exosome|,pyrimidine nucleobase metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|'de novo' pyrimidine nucleobase biosynthetic process|UTP biosynthetic process|glutamine metabolic process|glutamine catabolic process|female pregnancy|lactation|embryo development|response to amine|drug metabolic process|peptidyl-threonine phosphorylation|response to caffeine|organ regeneration|response to testosterone|cellular response to drug|'de novo' UMP biosynthetic process|small molecule metabolic process|pyrimidine nucleoside biosynthetic process|protein autophosphorylation|response to cortisol|nucleobase-containing small molecule metabolic process|carbamoyl phosphate biosynthetic process|cellular response to epidermal growth factor stimulus|,aspartate carbamoyltransferase activity|aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|dihydroorotase activity|dihydroorotase activity|protein kinase activity|ATP binding|zinc ion binding|enzyme binding|identical protein binding|aspartate binding|,10,-3.2,1.77,10,-2.1,2.46,-2.1,3.56,0.139,-7.7,2.1
ENSMUSG00000036309,SKP1A,S-phase kinase-associated protein 1A,cytosol|SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|PcG protein complex|extracellular vesicular exosome|,ubiquitin-dependent protein catabolic process|protein ubiquitination|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|histone H2A monoubiquitination|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|,6,3.9,1.74,6,5,2.45,4.3,3.55,0.139,-3,10
ENSMUSG00000026812,TSC1,tuberous sclerosis 1,cytoplasm|cytosol|cytosol|actin filament|cell cortex|membrane|lamellipodium|growth cone|TSC1-TSC2 complex|intracellular membrane-bounded organelle|protein complex|,kidney development|neural tube closure|regulation of cell-matrix adhesion|rRNA export from nucleus|regulation of translation|potassium ion transport|cell cycle arrest|cell-matrix adhesion|negative regulation of cell proliferation|insulin receptor signaling pathway|negative regulation of translation|hippocampus development|cerebral cortex development|cell projection organization|negative regulation of TOR signaling|activation of Rho GTPase activity|response to insulin|myelination|regulation of phosphoprotein phosphatase activity|negative regulation of cell size|regulation of protein kinase activity|negative regulation of insulin receptor signaling pathway|synapse organization|protein stabilization|protein heterooligomerization|regulation of stress fiber assembly|regulation of cell cycle|positive regulation of focal adhesion assembly|cardiac muscle cell differentiation|,protein binding|GTPase regulator activity|GTPase activating protein binding|protein N-terminus binding|chaperone binding|,10,-1.6,2.9,10,-1.2,0.981,-1.4,3.55,0.139,-3.9,0.5
ENSMUSG00000025246,TBL1X,transducin (beta)-like 1X-linked,histone deacetylase complex|nucleus|nucleoplasm|spindle microtubule|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|proteolysis|Notch signaling pathway|sensory perception of sound|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular lipid metabolic process|small molecule metabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|",transcription corepressor activity|transcription corepressor activity|protein binding|beta-catenin binding|protein C-terminus binding|transcription factor binding|protein domain specific binding|histone binding|transcription regulatory region DNA binding|,10,0.8,1.7,10,1.1,2.2,1,3.55,0.139,-0.6,3.2
ENSMUSG00000040046,TPH1,tryptophan hydroxylase 1,cytosol|neuron projection|,circadian rhythm|aromatic amino acid family metabolic process|negative regulation of ossification|cellular nitrogen compound metabolic process|response to immobilization stress|serotonin biosynthetic process|small molecule metabolic process|indolalkylamine biosynthetic process|bone remodeling|oxidation-reduction process|mammary gland alveolus development|,tryptophan 5-monooxygenase activity|iron ion binding|amino acid binding|,10,2.3,4.87,10,-0.1,0.00578,2.2,3.54,0.14,-1.4,7
ENSMUSG00000039840,EPG5,ectopic P-granules autophagy protein 5 homolog (C. elegans),None,autophagy|,None,9,2.6,2.72,9,1.5,1.66,2.1,3.54,0.14,-3.3,6.8
ENSMUSG00000052253,ZFP622,zinc finger protein 622,nucleus|nucleolus|cytoplasm|Golgi apparatus|,intrinsic apoptotic signaling pathway in response to oxidative stress|positive regulation of kinase activity|positive regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of JNK cascade|,nucleic acid binding|zinc ion binding|poly(A) RNA binding|metal ion binding|,9,-2.6,1.78,9,-1.6,2.14,-2.4,3.54,0.14,-8,7.5
ENSMUSG00000020708,PSMC5,"proteasome (prosome, macropain) 26S subunit, ATPase, 5",proteasome complex|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|inclusion body|proteasome accessory complex|cytoplasmic vesicle|nuclear proteasome complex|cytosolic proteasome complex|extracellular vesicular exosome|blood microparticle|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|transcription from RNA polymerase II promoter|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of programmed cell death|proteasome-mediated ubiquitin-dependent protein catabolic process|small molecule metabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of inclusion body assembly|",transcription cofactor activity|protein binding|ATP binding|transcription factor binding|ATPase activity|ATPase activity|TBP-class protein binding|thyrotropin-releasing hormone receptor binding|,8,3.6,2.2,8,1.8,2.13,2.1,3.54,0.14,-5.5,7.4
ENSMUSG00000060538,TMEM219,transmembrane protein 219,plasma membrane|integral component of membrane|,apoptotic process|,None,1,-2.5,0.972,1,-3.3,2.9,-3.2,3.54,0.14,-6,0.4
ENSMUSG00000040383,AQR,aquarius intron-binding spliceosomal factor,nucleus|membrane|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|",protein binding|poly(A) RNA binding|,8,1.7,1.24,8,1.3,2.57,1.4,3.54,0.14,-5.6,4.3
ENSMUSG00000043091,TUBA1C,"tubulin, alpha 1c",nucleus|microtubule|cytoplasmic microtubule|,GTP catabolic process|protein folding|microtubule-based process|cytoskeleton-dependent intracellular transport|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|cell division|,GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|,7,-5.2,0.58,7,-2.9,3.44,-3.1,3.54,0.14,-10,5.1
ENSMUSG00000035121,NEIL2,nei endonuclease VIII-like 2 (E. coli),nucleus|cytoplasm|spindle microtubule|,"DNA catabolic process, endonucleolytic|base-excision repair|nucleotide-excision repair|","damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|microtubule binding|zinc ion binding|hydrolase activity, hydrolyzing N-glycosyl compounds|",10,-3.6,4.01,10,-1.3,1.12,-3.3,3.54,0.14,-8.7,1.3
ENSMUSG00000055128,CGRRF1,cell growth regulator with ring finger domain 1,nucleus|intracellular membrane-bounded organelle|,response to stress|cell cycle arrest|negative regulation of cell proliferation|,zinc ion binding|,10,-2.2,5.2,10,0,0,-1.9,3.54,0.14,-7.6,2
ENSMUSG00000022525,HRASLS,HRAS-like suppressor,integral component of membrane|,lipid catabolic process|,transferase activity|hydrolase activity|,10,-1.7,3.44,10,-0.9,0.669,-1.6,3.53,0.141,-5.3,1.3
ENSMUSG00000039414,HEATR5B,HEAT repeat containing 5B,membrane|extracellular vesicular exosome|,None,None,2,-3.5,3.69,0,0,0,-3.5,3.53,0.141,-7,0.4
ENSMUSG00000070327,RNF213,ring finger protein 213,cytoplasm|membrane|,ATP catabolic process|protein ubiquitination|protein autoubiquitination|,nucleotide binding|ubiquitin-protein transferase activity|zinc ion binding|ligase activity|ATPase activity|,10,-2.4,4.13,10,1.2,0.42,-1.9,3.53,0.141,-6.7,3.1
ENSMUSG00000070331,QRICH2,glutamine rich 2,None,None,None,0,0,0,1,3.5,3.67,3.5,3.52,0.141,-0.4,7
ENSMUSG00000068457,UTY,"ubiquitously transcribed tetratricopeptide repeat containing, Y-linked",nucleus|,in utero embryonic development|heart development|regulation of chromatin silencing|establishment of protein localization|oxidation-reduction process|canonical Wnt signaling pathway|histone H3-K36 demethylation|cardiac muscle cell contraction|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|metal ion binding|histone demethylase activity (H3-K36 specific)|,10,3.6,1.41,10,-2.5,3.84,-2.4,3.52,0.141,-6.7,6.5
ENSMUSG00000024817,UHRF2,"ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase",nucleus|nuclear heterochromatin|,ubiquitin-dependent protein catabolic process|cell cycle|cell proliferation|protein ubiquitination|cell differentiation|regulation of cell cycle|protein autoubiquitination|positive regulation of cell cycle arrest|,DNA binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|histone binding|,10,-2.3,1.12,10,-1.6,2.82,-1.7,3.52,0.141,-7.2,0.9
ENSMUSG00000011486,SLC25A41,"solute carrier family 25, member 41",mitochondrial inner membrane|integral component of membrane|,transmembrane transport|,None,0,0,0,1,3.5,3.67,3.5,3.52,0.141,-0.4,7
ENSMUSG00000044827,TLR1,toll-like receptor 1,plasma membrane|integral component of plasma membrane|membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex|,MyD88-dependent toll-like receptor signaling pathway|inflammatory response|immune response|signal transduction|toll-like receptor 1 signaling pathway|macrophage activation|detection of triacyl bacterial lipopeptide|positive regulation of tumor necrosis factor biosynthetic process|innate immune response|positive regulation of interleukin-6 biosynthetic process|regulation of cytokine secretion|cellular response to triacyl bacterial lipopeptide|,receptor activity|transmembrane signaling receptor activity|protein heterodimerization activity|,10,2.8,2.39,10,-3.4,3.47,-2.4,3.51,0.142,-7.6,4.3
ENSMUSG00000056367,ACTR3B,ARP3 actin-related protein 3 homolog B (yeast),cellular_component|cytoplasm|cytoskeleton|cell projection|,biological_process|,molecular_function|actin binding|ATP binding|,10,-2.4,1.68,10,-1.5,2.3,-2.1,3.51,0.142,-6.8,0.8
ENSMUSG00000091526,BB019430,expressed sequence BB019430,None,None,None,1,3.3,3.67,0,0,0,3.3,3.51,0.142,-0.4,7
ENSMUSG00000046207,PIK3R6,"phosphoinositide-3-kinase, regulatory subunit 6","cytosol|1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex|membrane|",angiogenesis|phospholipid metabolic process|phosphatidylinositol biosynthetic process|G-protein coupled receptor signaling pathway|blood coagulation|platelet activation|positive regulation of MAP kinase activity|regulation of phosphatidylinositol 3-kinase activity|regulation of phosphatidylinositol 3-kinase activity|small molecule metabolic process|positive regulation of angiogenesis|phosphatidylinositol phosphorylation|phosphatidylinositol phosphorylation|,"protein binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity|",10,2.2,5.04,10,-0.5,0.126,1.8,3.5,0.143,-1.6,6.5
ENSMUSG00000019845,TUBE1,"tubulin, epsilon 1",pericentriolar material|microtubule|,GTP catabolic process|centrosome cycle|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|GTP binding|,9,-2.6,3.94,10,-1.1,0.569,-1.4,3.5,0.143,-6.3,1.7
ENSMUSG00000028310,PPP3R2,"protein phosphatase 3, regulatory subunit B, beta",None,None,calcium ion binding|,10,0,0,10,-5.9,6.34,-1.4,3.5,0.143,-11.8,-0.2
ENSMUSG00000031253,SRPX2,"sushi-repeat containing protein, X-linked 2",extracellular space|cytoplasm|cell surface|cell junction|excitatory synapse|synaptic membrane|,angiogenesis|single organismal cell-cell adhesion|regulation of phosphorylation|cell motility|positive regulation of synapse assembly|positive regulation of cell migration involved in sprouting angiogenesis|,receptor binding|protein binding|hepatocyte growth factor binding|identical protein binding|,10,1.8,0.633,10,-1.8,3.5,-1.8,3.49,0.143,-6.2,2.8
ENSMUSG00000062580,TIMM17A,translocase of inner mitochondrial membrane 17 homolog A (yeast),mitochondrial inner membrane presequence translocase complex|integral component of mitochondrial inner membrane|,protein targeting to mitochondrion|cellular protein metabolic process|protein transmembrane transport|,P-P-bond-hydrolysis-driven protein transmembrane transporter activity|,10,-3.4,0.524,10,-1.9,3.49,-1.8,3.49,0.143,-7.7,1.5
ENSMUSG00000042632,PLA2G6,"phospholipase A2, group VI (cytosolic, calcium-independent)",mitochondrion|cytosol|membrane|,"positive regulation of protein phosphorylation|phospholipid metabolic process|chemotaxis|positive regulation of cytosolic calcium ion concentration|memory|cell death|urinary bladder smooth muscle contraction|lipid catabolic process|cardiolipin biosynthetic process|response to endoplasmic reticulum stress|positive regulation of insulin secretion involved in cellular response to glucose stimulus|cardiolipin acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|Fc-gamma receptor signaling pathway involved in phagocytosis|small molecule metabolic process|innate immune response|positive regulation of vasodilation|positive regulation of exocytosis|glycerophospholipid biosynthetic process|negative regulation of synaptic transmission, glutamatergic|maternal process involved in female pregnancy|positive regulation of protein kinase C signaling|positive regulation of release of cytochrome c from mitochondria|positive regulation of arachidonic acid secretion|regulation of store-operated calcium channel activity|positive regulation of ceramide biosynthetic process|",phospholipase A2 activity|calmodulin binding|ATP-dependent protein binding|calcium-independent phospholipase A2 activity|,10,2.4,3.57,10,-1.9,2.72,2,3.49,0.143,-5.7,6.4
ENSMUSG00000029551,PSMG3,"proteasome (prosome, macropain) assembly chaperone 3",None,None,None,1,-3.9,2.18,4,-3.4,1.58,-3.6,3.49,0.143,-8,0.1
ENSMUSG00000066440,ZFYVE26,"zinc finger, FYVE domain containing 26",lysosomal membrane|centrosome|midbody|,double-strand break repair via homologous recombination|cytokinesis|cell death|,protein binding|phosphatidylinositol-3-phosphate binding|metal ion binding|,9,-4.5,5.46,9,-0.6,0.413,-3.6,3.48,0.144,-8.9,0.3
ENSMUSG00000021186,FBLN5,fibulin 5,extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular matrix|extracellular vesicular exosome|elastic fiber|,regulation of cell growth|cell-matrix adhesion|extracellular matrix organization|protein localization to cell surface|elastic fiber assembly|regulation of removal of superoxide radicals|,integrin binding|calcium ion binding|protein binding|protein C-terminus binding|,10,3.9,3.41,10,-1.2,2.36,-1,3.48,0.144,-8.3,8.6
ENSMUSG00000074968,ANO3,anoctamin 3,plasma membrane|integral component of membrane|,ion transmembrane transport|transmembrane transport|,None,10,-3.7,3.27,10,-1.7,1.72,-3.4,3.48,0.144,-8.3,1.2
ENSMUSG00000067616,KLK11,kallikrein-related peptidase 11,extracellular space|Golgi apparatus|,proteolysis|,serine-type endopeptidase activity|serine-type peptidase activity|,1,3.3,3.63,0,0,0,3.3,3.47,0.144,-0.4,7
ENSMUSG00000020883,FBXL20,F-box and leucine-rich repeat protein 20,cytoplasm|,None,None,10,6.3,3.35,10,-2.9,4.05,-2.7,3.47,0.144,-8.4,11
ENSMUSG00000089929,BCL2A1B,B cell leukemia/lymphoma 2 related protein A1b,mitochondrial outer membrane|,intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein homodimerization activity|protein heterodimerization activity|protein heterodimerization activity|BH domain binding|,7,-1.1,0.492,7,-5.9,5.62,-5.7,3.47,0.144,-12,2
ENSMUSG00000023004,TUBA1B,"tubulin, alpha 1b",microtubule|microtubule|cytoplasmic microtubule|extracellular vesicular exosome|,microtubule cytoskeleton organization|GTP catabolic process|protein folding|microtubule-based process|cytoskeleton-dependent intracellular transport|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|cell division|cellular response to interleukin-4|,double-stranded RNA binding|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|,2,2.1,1.38,3,4.2,2.93,4,3.46,0.145,-6,9
ENSMUSG00000031950,GABARAPL2,GABA(A) receptor-associated protein-like 2,Golgi membrane|Golgi membrane|autophagic vacuole membrane|intracellular|cytoplasm|autophagic vacuole|Golgi apparatus|cytosol|cytoplasmic vesicle|,intra-Golgi vesicle-mediated transport|autophagy|protein transport|positive regulation of ATPase activity|negative regulation of proteasomal protein catabolic process|,SNARE binding|protein binding|microtubule binding|beta-tubulin binding|GABA receptor binding|GABA receptor binding|ATPase binding|,9,-1.3,0.915,10,-2.7,3.33,-2.6,3.46,0.145,-7.1,0.8
ENSMUSG00000026478,LAMC1,"laminin, gamma 1 (formerly LAMB2)",extracellular region|basement membrane|laminin-1 complex|laminin-1 complex|extracellular space|extracellular matrix|extracellular matrix|laminin-10 complex|laminin-11 complex|extracellular vesicular exosome|,protein complex assembly|cell adhesion|axon guidance|endoderm development|cell migration|extracellular matrix disassembly|extracellular matrix disassembly|extracellular matrix organization|hemidesmosome assembly|substrate adhesion-dependent cell spreading|positive regulation of epithelial cell proliferation|,extracellular matrix structural constituent|glycosphingolipid binding|,9,-1.2,0.859,10,-1.7,2.9,-1.4,3.46,0.145,-8.4,3.6
ENSMUSG00000021974,FGF9,fibroblast growth factor 9,extracellular region|basement membrane|extracellular space|cytoplasm|extracellular vesicular exosome|,negative regulation of transcription from RNA polymerase II promoter|angiogenesis|osteoblast differentiation|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|protein import into nucleus|signal transduction|epidermal growth factor receptor signaling pathway|cell-cell signaling|positive regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|male gonad development|positive regulation of gene expression|substantia nigra development|negative regulation of Wnt signaling pathway|male sex determination|embryonic limb morphogenesis|positive regulation of vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|inner ear morphogenesis|positive regulation of MAPK cascade|innate immune response|positive regulation of smoothened signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of timing of cell differentiation|embryonic digestive tract development|embryonic skeletal system development|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of cardiac muscle cell proliferation|lung-associated mesenchyme development|positive regulation of canonical Wnt signaling pathway|,fibroblast growth factor receptor binding|growth factor activity|heparin binding|,9,-2.3,0.689,9,-3,3.12,-2.7,3.46,0.145,-8,1.6
ENSMUSG00000030657,XYLT1,xylosyltransferase I,Golgi membrane|extracellular region|endoplasmic reticulum membrane|integral component of membrane|,glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|chondroitin sulfate biosynthetic process|cellular response to heat|,acetylglucosaminyltransferase activity|protein xylosyltransferase activity|,0,0,0,1,3.4,3.62,3.4,3.46,0.145,-0.4,7
ENSMUSG00000039639,KCNE1,"potassium voltage-gated channel, Isk-related family, member 1",lysosome|endoplasmic reticulum|plasma membrane|voltage-gated potassium channel complex|voltage-gated potassium channel complex|cell surface|apical plasma membrane|Z disc|,epithelial cell maturation|protein N-linked glycosylation|protein O-linked glycosylation|sensory perception of sound|male gonad development|heart contraction|regulation of ventricular cardiac muscle cell membrane repolarization|cellular response to cAMP|potassium ion export|cellular response to acidity|potassium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|membrane repolarization|membrane repolarization during action potential|membrane repolarization during cardiac muscle cell action potential|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|negative regulation of protein targeting to membrane|regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity|,voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|potassium channel regulator activity|telethonin binding|protein heterodimerization activity|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|,1,3.3,3.61,0,0,0,3.3,3.45,0.146,-0.4,7
ENSMUSG00000026430,RASSF5,Ras association (RalGDS/AF-6) domain family member 5,nucleus|cytoplasm|microtubule|,apoptotic process|positive regulation of protein ubiquitination|intracellular signal transduction|,protein binding|metal ion binding|,10,-1.1,0.617,10,-1.5,3.14,-1.3,3.45,0.146,-5.6,3.4
ENSMUSG00000047777,PHF13,PHD finger protein 13,nucleus|nucleoplasm|,mitotic cell cycle|chromosome segregation|mitotic chromosome condensation|chromatin modification|,chromatin binding|zinc ion binding|methylated histone binding|,10,-1.9,0.892,10,-1.5,2.91,-1.8,3.45,0.146,-4.3,1.1
ENSMUSG00000021298,GPR132,G protein-coupled receptor 132,plasma membrane|integral component of membrane|,G1/S transition of mitotic cell cycle|response to stress|G-protein coupled receptor signaling pathway|,G-protein coupled receptor activity|,10,-7.1,3.87,10,1.2,1.21,-1.5,3.44,0.147,-12.2,2.1
ENSMUSG00000096581,BCL2A1D,B cell leukemia/lymphoma 2 related protein A1d,mitochondrial outer membrane|,intrinsic apoptotic signaling pathway in response to DNA damage|T cell differentiation|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|T cell receptor signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein homodimerization activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|protein heterodimerization activity|protein heterodimerization activity|BH domain binding|,10,-0.5,0.361,10,-5.9,4.43,-5.8,3.43,0.148,-11.4,-0.1
ENSMUSG00000079593,GM14597,N/A,None,None,None,0,0,0,2,2.5,3.59,2.5,3.43,0.148,-0.8,5
ENSMUSG00000003484,CYP4F18,"cytochrome P450, family 4, subfamily f, polypeptide 18",cytoplasm|endoplasmic reticulum|membrane|integral component of membrane|apical plasma membrane|intracellular membrane-bounded organelle|,very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|regulation of blood pressure|drug metabolic process|arachidonic acid metabolic process|epoxygenase P450 pathway|negative regulation of blood coagulation|negative regulation of icosanoid secretion|positive regulation of icosanoid secretion|leukotriene B4 catabolic process|vitamin E metabolic process|vitamin K biosynthetic process|oxidation-reduction process|,"monooxygenase activity|iron ion binding|arachidonic acid epoxygenase activity|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|alkane 1-monooxygenase activity|heme binding|metal ion binding|vitamin-K-epoxide reductase (warfarin-sensitive) activity|leukotriene-B4 20-monooxygenase activity|arachidonic acid omega-hydroxylase activity|tocopherol omega-hydroxylase activity|alpha-tocopherol omega-hydroxylase activity|tocotrienol omega-hydroxylase activity|",0,0,0,3,2.1,3.59,2.1,3.43,0.148,-0.6,5
ENSMUSG00000036707,CAB39,calcium binding protein 39,cytosol|protein complex|extracellular vesicular exosome|,cell cycle arrest|insulin receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|signal transduction by phosphorylation|activation of protein kinase activity|intracellular signal transduction|protein heterooligomerization|cellular hypotonic response|positive regulation of protein serine/threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of rubidium ion transport|negative regulation of rubidium ion transmembrane transporter activity|,protein serine/threonine kinase activity|protein binding|kinase binding|protein kinase activator activity|protein serine/threonine kinase activator activity|,9,-0.8,0.179,9,-3.3,4.41,-2.6,3.43,0.148,-7.5,1.8
ENSMUSG00000019179,MDH2,"malate dehydrogenase 2, NAD (mitochondrial)",nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|plasma membrane|extracellular vesicular exosome|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|malate metabolic process|internal protein amino acid acetylation|NADH metabolic process|cellular metabolic process|cellular carbohydrate metabolic process|small molecule metabolic process|,L-malate dehydrogenase activity|L-malate dehydrogenase activity|L-malate dehydrogenase activity|protein self-association|poly(A) RNA binding|malate dehydrogenase (NADP+) activity|,9,-3.9,1.98,10,-1.5,2.3,-2,3.42,0.148,-7.4,3
ENSMUSG00000021359,TFAP2A,transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha),nucleus|nucleus|cytoplasm|Golgi apparatus|centrosome|intracellular membrane-bounded organelle|,"negative regulation of transcription from RNA polymerase II promoter|kidney development|outflow tract morphogenesis|keratinocyte development|optic vesicle morphogenesis|optic cup structural organization|transcription from RNA polymerase II promoter|sensory perception of sound|negative regulation of cell proliferation|embryonic pattern specification|embryonic body morphogenesis|positive regulation of gene expression|retina layer formation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription by competitive promoter binding|neural crest cell development|anterior neuropore closure|trigeminal nerve development|oculomotor nerve formation|forebrain neuron development|positive regulation of cell migration|positive regulation of bone mineralization|embryonic forelimb morphogenesis|negative regulation of epidermal growth factor receptor signaling pathway|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|regulation of cell differentiation|regulation of neuron differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|sympathetic nervous system development|embryonic cranial skeleton morphogenesis|epidermis morphogenesis|palate development|lens induction in camera-type eye|face morphogenesis|bone morphogenesis|eyelid development in camera-type eye|cornea development in camera-type eye|positive regulation of tooth mineralization|cellular response to iron ion|basement membrane organization|metanephric nephron development|negative regulation of reactive oxygen species metabolic process|",transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription corepressor activity|chromatin binding|transcription coactivator activity|protein binding|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|protein dimerization activity|,10,2,5.67,10,-1,1.26,1.8,3.42,0.148,-5.9,5.2
ENSMUSG00000021400,WRNIP1,Werner helicase interacting protein 1,nucleus|nucleus|membrane|perinuclear region of cytoplasm|,DNA synthesis involved in DNA repair|ATP catabolic process|ATP catabolic process|DNA replication|regulation of DNA-dependent DNA replication initiation|,DNA binding|protein binding|ATP binding|ATPase activity|identical protein binding|metal ion binding|,8,0.2,0.0516,8,-2.6,4.22,-2.7,3.42,0.148,-6.3,1.6
ENSMUSG00000023979,GUCA1B,guanylate cyclase activator 1B (retina),photoreceptor inner segment|photoreceptor disc membrane|,"receptor guanylyl cyclase signaling pathway|cell-cell signaling|body fluid secretion|visual perception|phototransduction, visible light|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|positive regulation of guanylate cyclase activity|positive regulation of guanylate cyclase activity|",calcium ion binding|calcium sensitive guanylate cyclase activator activity|,1,3.3,3.57,0,0,0,3.3,3.41,0.149,-0.4,7
ENSMUSG00000034349,SMC4,structural maintenance of chromosomes 4,condensin complex|condensin complex|nucleus|nucleus|nucleoplasm|cytoplasm|cytosol|,mitotic sister chromatid segregation|mitotic cell cycle|mitotic chromosome condensation|meiotic chromosome condensation|meiotic chromosome segregation|kinetochore organization|,protein binding|ATP binding|protein heterodimerization activity|,8,-4.5,2.26,6,6.1,4.85,-4.2,3.41,0.149,-8.6,10.7
ENSMUSG00000030630,FAH,fumarylacetoacetate hydrolase (fumarylacetoacetase),cytosol|extracellular vesicular exosome|,arginine catabolic process|L-phenylalanine catabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|,fumarylacetoacetase activity|metal ion binding|,0,0,0,1,3.4,3.57,3.4,3.41,0.149,-0.4,7
ENSMUSG00000027863,CD2,CD2 molecule,extracellular region|plasma membrane|integral component of plasma membrane|external side of plasma membrane|cytoplasmic side of plasma membrane|cell surface|anchored component of plasma membrane|,membrane raft polarization|apoptotic process|cell surface receptor signaling pathway|blood coagulation|single organismal cell-cell adhesion|natural killer cell activation|positive regulation of myeloid dendritic cell activation|positive regulation of tumor necrosis factor production|heterotypic cell-cell adhesion|T cell activation|regulation of T cell differentiation|leukocyte migration|positive regulation of interferon-gamma secretion|positive regulation of interleukin-8 secretion|,receptor activity|receptor binding|protein binding|protein homodimerization activity|,10,-2.6,1.87,10,-1.7,1.93,-2.4,3.41,0.149,-6.6,0.8
ENSMUSG00000063730,HSD3B2,"hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|smooth endoplasmic reticulum membrane|mitochondrial membrane|,steroid biosynthetic process|androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|steroid metabolic process|small molecule metabolic process|oxidation-reduction process|,3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid delta-isomerase activity|,10,5.3,1.78,10,5.9,1.98,5.6,3.39,0.15,-0.7,12
ENSMUSG00000044338,APLNR,apelin receptor,plasma membrane|integral component of plasma membrane|,G-protein coupled receptor signaling pathway|gastrulation|heart development|regulation of body fluid levels|,receptor activity|G-protein coupled receptor activity|,10,1.5,2.49,10,1.1,1.22,1.3,3.38,0.151,-4,5.4
ENSMUSG00000030711,SULT1A1,"sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1",cytosol|,catecholamine metabolic process|xenobiotic metabolic process|xenobiotic metabolic process|estrogen metabolic process|amine metabolic process|flavonoid metabolic process|small molecule metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|,aryl sulfotransferase activity|aryl sulfotransferase activity|sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid sulfotransferase activity|,0,0,0,2,3.9,3.53,3.9,3.38,0.151,-2.4,8
ENSMUSG00000046010,ZFP830,zinc finger protein 830,nucleus|nucleus|nucleus|chromosome|cytoplasm|nuclear speck|,blastocyst growth|cell cycle|mitotic nuclear division|multicellular organismal development|nuclear cell cycle DNA replication|mitotic DNA damage checkpoint|chromosome organization|cell division|intestinal epithelial structure maintenance|,molecular_function|metal ion binding|,10,3.9,1.21,10,-3.9,2.5,-3.9,3.38,0.151,-9.3,4.6
ENSMUSG00000038067,CSF3,colony stimulating factor 3 (granulocyte),extracellular space|,immune response|multicellular organismal development|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|positive regulation of actin filament polymerization|granulocyte differentiation|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|negative regulation of neuron death|positive regulation of actin cytoskeleton reorganization|,cytokine activity|cytokine activity|granulocyte colony-stimulating factor receptor binding|growth factor activity|enzyme binding|,10,-0.2,0.0343,10,2.8,6.13,2.7,3.37,0.152,-2,6.3
ENSMUSG00000010760,PHLDA2,"pleckstrin homology-like domain, family A, member 2",cytoplasm|membrane|,placenta development|apoptotic process|organ morphogenesis|regulation of gene expression|regulation of cell migration|regulation of embryonic development|regulation of glycogen metabolic process|,None,10,-4.8,5.9,10,-0.6,0.208,-4.7,3.37,0.152,-9.6,1.5
ENSMUSG00000006403,ADAMTS4,"ADAM metallopeptidase with thrombospondin type 1 motif, 4",extracellular region|proteinaceous extracellular matrix|extracellular space|,skeletal system development|proteolysis|extracellular matrix disassembly|extracellular matrix organization|,protease binding|metalloendopeptidase activity|protein binding|peptidase activity|metallopeptidase activity|zinc ion binding|,1,-3.3,1.74,1,3.7,4.01,3.6,3.37,0.152,-5.7,7
ENSMUSG00000036875,DNA2,DNA replication helicase/nuclease 2,nucleus|nucleoplasm|gamma DNA polymerase complex|mitochondrial nucleoid|,"DNA replication checkpoint|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA double-strand break processing|DNA catabolic process, endonucleolytic|ATP catabolic process|ATP catabolic process|DNA replication|mitochondrial DNA replication|DNA strand elongation involved in DNA replication|base-excision repair|telomere maintenance via semi-conservative replication|DNA duplex unwinding|DNA replication, Okazaki fragment processing|DNA replication, removal of RNA primer|mitochondrial DNA repair|positive regulation of DNA replication|","DNA binding|DNA helicase activity|helicase activity|nuclease activity|protein binding|ATP binding|ATPase activity|site-specific endodeoxyribonuclease activity, specific for altered base|5'-flap endonuclease activity|5'-3' DNA helicase activity|single-stranded DNA-dependent ATPase activity|metal ion binding|4 iron, 4 sulfur cluster binding|",7,-3.1,2.93,8,2.9,3.55,-2.8,3.37,0.152,-6.3,5.5
ENSMUSG00000032534,CEP63,centrosomal protein 63kDa,spindle pole|centrosome|centriole|cytosol|,DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|centriole replication|signal transduction in response to DNA damage|spindle assembly|,protein binding|,1,3.2,3.52,0,0,0,3.2,3.36,0.152,-0.5,7
ENSMUSG00000030432,RPL28,ribosomal protein L28,cytoplasm|cytosol|membrane|cytosolic large ribosomal subunit|dendrite|cytoplasmic ribonucleoprotein granule|cell body|extracellular vesicular exosome|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|cellular protein metabolic process|",RNA binding|structural constituent of ribosome|protein binding|poly(A) RNA binding|,0,0,0,2,2.5,3.51,2.5,3.36,0.152,-0.8,5
ENSMUSG00000028207,ASPH,aspartate beta-hydroxylase,endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|junctional sarcoplasmic reticulum membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|sarcoplasmic reticulum lumen|calcium channel complex|,"detection of calcium ion|muscle contraction|pattern specification process|negative regulation of cell proliferation|positive regulation of calcium ion transport into cytosol|regulation of cell communication by electrical coupling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|regulation of protein stability|activation of store-operated calcium channel activity|response to ATP|limb morphogenesis|peptidyl-aspartic acid hydroxylation|positive regulation of proteolysis|positive regulation of transcription, DNA-templated|oxidation-reduction process|palate development|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|face morphogenesis|calcium ion transmembrane transport|cellular response to calcium ion|positive regulation of intracellular protein transport|activation of cysteine-type endopeptidase activity|regulation of protein depolymerization|",peptide-aspartate beta-dioxygenase activity|structural molecule activity|calcium ion binding|calcium ion binding|protein binding|structural constituent of muscle|electron carrier activity|ion channel binding|,10,-1,0.823,10,-2.6,3.45,-1.5,3.36,0.152,-6.7,2.7
ENSMUSG00000030805,STX4A,syntaxin 4A (placental),cell|cytoplasm|trans-Golgi network|plasma membrane|plasma membrane|cell surface|cell surface|membrane|integral component of membrane|basolateral plasma membrane|basolateral plasma membrane|apical plasma membrane|SNARE complex|myelin sheath adaxonal region|sarcolemma|specific granule|lateral loop|perinuclear region of cytoplasm|extracellular vesicular exosome|,protein complex assembly|transport|neurotransmitter transport|intracellular protein transport|synaptic vesicle exocytosis|synaptic vesicle docking involved in exocytosis|vesicle-mediated transport|SNARE complex assembly|membrane fusion|,SNARE binding|SNARE binding|SNAP receptor activity|protein binding|Rab GTPase binding|spectrin binding|,2,3.7,4.05,1,-0.3,0.0222,3.7,3.35,0.153,-0.2,8
ENSMUSG00000025287,ACOT9,acyl-CoA thioesterase 9,mitochondrion|,acyl-CoA metabolic process|,acetyl-CoA hydrolase activity|,0,0,0,2,2.5,3.51,2.5,3.35,0.153,-0.8,5
ENSMUSG00000060743,H3F3A,"H3 histone, family 3A",None,None,None,5,5.5,3.92,5,-1.8,1.47,-2.3,3.35,0.153,-7,10
ENSMUSG00000093923,GM5935,predicted gene 5935,cellular_component|,biological_process|,molecular_function|,2,-5,3.31,3,3.9,4.44,3.9,3.35,0.153,-8.4,8
ENSMUSG00000017421,ZFP207,zinc finger protein 207,"chromosome, centromeric region|kinetochore|nucleus|nucleus|chromosome|microtubule|",mitotic sister chromatid segregation|cell cycle|chromosome segregation|mitotic nuclear division|mitotic spindle assembly checkpoint|attachment of spindle microtubules to kinetochore|protein stabilization|cell division|regulation of chromosome segregation|,microtubule binding|heparin binding|poly(A) RNA binding|metal ion binding|,1,-1.4,0.603,1,-3.7,3.27,-3.6,3.34,0.154,-7,0.3
ENSMUSG00000032966,FKBP1A,"FK506 binding protein 1A, 12kDa",cytoplasm|endoplasmic reticulum membrane|cytosol|cytosol|terminal cisterna|membrane|Z disc|extracellular vesicular exosome|,protein peptidyl-prolyl isomerization|heart morphogenesis|protein folding|'de novo' protein folding|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|protein maturation by protein folding|positive regulation of protein ubiquitination|positive regulation of protein binding|negative regulation of protein phosphatase type 2B activity|regulation of protein localization|regulation of activin receptor signaling pathway|protein refolding|T cell activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular fibril organization|regulation of immune response|ventricular cardiac muscle tissue morphogenesis|regulation of ryanodine-sensitive calcium-release channel activity|regulation of ryanodine-sensitive calcium-release channel activity|heart trabecula formation|chaperone-mediated protein folding|calcium ion transmembrane transport|regulation of amyloid precursor protein catabolic process|amyloid fibril formation|,peptidyl-prolyl cis-trans isomerase activity|peptidyl-prolyl cis-trans isomerase activity|signal transducer activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor binding|ryanodine-sensitive calcium-release channel activity|protein binding|macrolide binding|FK506 binding|FK506 binding|type I transforming growth factor beta receptor binding|ion channel binding|SMAD binding|activin binding|,10,0,0,10,-5.9,5.01,-1.3,3.34,0.154,-11.4,0
ENSMUSG00000028899,TAF12,"TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa",PCAF complex|nucleoplasm|transcription factor TFIID complex|STAGA complex|STAGA complex|transcription factor TFTC complex|,"chromatin organization|DNA-templated transcription, initiation|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|histone H3 acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of RNA biosynthetic process|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|transcription factor binding|protein heterodimerization activity|,9,0,0,9,-3,4.46,-2.1,3.33,0.154,-6,1.9
ENSMUSG00000021256,VASH1,vasohibin 1,extracellular space|cytoplasm|endoplasmic reticulum|apical part of cell|,angiogenesis|negative regulation of endothelial cell proliferation|cell cycle arrest|response to wounding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of lymphangiogenesis|regulation of cellular senescence|,None,10,-1.1,0.804,10,-2,3.01,-1.5,3.33,0.154,-5.7,1.9
ENSMUSG00000030965,FAM175B,"family with sequence similarity 175, member B",BRISC complex|,None,polyubiquitin binding|,10,-2.3,2.4,9,-1.9,1.2,-2.2,3.33,0.154,-7.3,2.5
ENSMUSG00000027936,CRTC2,CREB regulated transcription coactivator 2,nucleus|cytoplasm|extracellular vesicular exosome|,"gluconeogenesis|transcription, DNA-templated|viral process|positive regulation of CREB transcription factor activity|glucose homeostasis|protein homotetramerization|",protein binding|cAMP response element binding protein binding|,1,3.2,3.48,0,0,0,3.2,3.32,0.155,-0.5,7
ENSMUSG00000019773,FBXO5,F-box protein 5,nucleus|nucleoplasm|cytoplasm|spindle|cytosol|,G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|oocyte maturation|spindle assembly involved in female meiosis I|metaphase/anaphase transition of mitotic cell cycle|regulation of mitotic cell cycle|vesicle organization|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of meiosis|microtubule polymerization|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|inhibition of mitotic anaphase-promoting complex activity|,protein binding|protein kinase binding|metal ion binding|,5,-7,5.36,5,0.3,0.0532,-6.9,3.32,0.155,-14,10.6
ENSMUSG00000022248,RAD1,RAD1 homolog (S. pombe),nucleus|nucleus|nucleoplasm|intracellular membrane-bounded organelle|,"cell cycle checkpoint|DNA damage checkpoint|DNA catabolic process, exonucleolytic|DNA replication|DNA repair|cellular response to DNA damage stimulus|meiotic prophase I|substantia nigra development|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|",damaged DNA binding|protein binding|3'-5' exonuclease activity|exodeoxyribonuclease III activity|,10,-4,3.5,9,-0.3,0.206,-4,3.31,0.156,-9.3,1.7
ENSMUSG00000020232,HMG20B,high mobility group 20B,nucleus|nucleoplasm|chromosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|blood coagulation|chromatin modification|negative regulation of protein sumoylation|skeletal muscle cell differentiation|positive regulation of neuron differentiation|",DNA binding|protein binding|protein heterodimerization activity|,10,-1.4,1.93,10,-1.7,1.64,-1.5,3.3,0.157,-5.9,1.9
ENSMUSG00000035540,GC,group-specific component (vitamin D binding protein),extracellular region|extracellular region|extracellular space|cytosol|lysosomal lumen|extracellular vesicular exosome|blood microparticle|,steroid metabolic process|vitamin D metabolic process|small molecule metabolic process|vitamin transport|,actin binding|vitamin D binding|vitamin transporter activity|calcidiol binding|,1,3.5,3.97,1,-2.5,1.11,3.4,3.29,0.157,-3.5,8
ENSMUSG00000031329,TSX,testis specific X-linked gene,nucleus|cytoplasm|,male gonad development|fertilization|adult behavior|,molecular_function|,10,-5.7,3.42,10,-2.2,2.7,-5.5,3.29,0.157,-10,0.9
ENSMUSG00000058835,ABI1,abl-interactor 1,intracellular|nucleus|endoplasmic reticulum|cytosol|postsynaptic density|lamellipodium|cell junction|filopodium|growth cone|SCAR complex|postsynaptic membrane|extracellular vesicular exosome|,somitogenesis|cellular component movement|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|megakaryocyte development|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|positive regulation of protein tyrosine kinase activity|lamellipodium morphogenesis|,protein binding|cytoskeletal protein binding|protein tyrosine kinase activator activity|protein complex binding|,8,1.3,0.586,10,-2.1,3.48,-2.1,3.29,0.157,-5.2,2.5
ENSMUSG00000024132,ECI1,enoyl-CoA delta isomerase 1,mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial matrix|extracellular vesicular exosome|,fatty acid beta-oxidation|fatty acid beta-oxidation|fatty acid beta-oxidation|cellular lipid metabolic process|small molecule metabolic process|,dodecenoyl-CoA delta-isomerase activity|dodecenoyl-CoA delta-isomerase activity|intramolecular oxidoreductase activity|,0,0,0,1,3.4,3.45,3.4,3.29,0.157,-0.5,7
ENSMUSG00000094624,GM4836,predicted gene 4836,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000026219,TRIP12,thyroid hormone receptor interactor 12,nucleus|nucleus|nucleoplasm|cytoplasm|,DNA repair|cellular response to DNA damage stimulus|embryo development|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ligase activity|thyroid hormone receptor binding|,10,-1.8,1.26,10,-1.5,2.33,-1.6,3.28,0.158,-5.7,1
ENSMUSG00000039621,PREX1,"phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1",cytoplasm|cytosol|plasma membrane|growth cone|dendritic shaft|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,superoxide metabolic process|actin filament polymerization|regulation of actin filament polymerization|positive regulation of Rho GTPase activity|positive regulation of Rho GTPase activity|intracellular signal transduction|neutrophil activation|regulation of dendrite development|,Rho guanyl-nucleotide exchange factor activity|Rho GTPase activator activity|protein binding|phospholipid binding|enzyme binding|,0,0,0,2,-4.4,3.44,-4.4,3.28,0.158,-9,0.1
ENSMUSG00000073245,GM14819,predicted gene 14819,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000095293,GM10058,predicted gene 10058,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000095887,GM10096,predicted gene 10096,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000073247,GM10486,predicted gene 10486,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000096457,GM10147,predicted gene 10147,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000073255,GM14632,predicted gene 14632,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000032056,BTG4,B-cell translocation gene 4,cellular_component|,cell cycle arrest|negative regulation of cell proliferation|neuron differentiation|negative regulation of mitotic cell cycle|,None,8,-1.7,2.57,8,1.8,1.86,-1.7,3.28,0.158,-6.9,4
ENSMUSG00000094759,GM10487,predicted gene 10487,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000073257,GM10488,predicted gene 10488,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000042388,DLGAP3,"discs, large (Drosophila) homolog-associated protein 3",postsynaptic density|cell junction|postsynaptic membrane|,cell-cell signaling|,beta-amyloid binding|protein binding|,1,3.2,3.44,0,0,0,3.2,3.28,0.158,-0.5,7
ENSMUSG00000095546,GM10230,predicted gene 10230,cellular_component|,biological_process|,molecular_function|,5,-4.7,5.04,6,3.8,2.3,-2.9,3.28,0.158,-9.9,5
ENSMUSG00000014748,TEX261,testis expressed 261,integral component of membrane|,None,None,10,-1.1,1.84,10,-2.2,2.4,-1.4,3.27,0.158,-5.5,2.2
ENSMUSG00000021301,HECW1,"HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1",cytoplasm|,protein ubiquitination involved in ubiquitin-dependent protein catabolic process|,ubiquitin-protein transferase activity|ligase activity|,10,5.2,6.13,10,-0.9,0.11,4.6,3.27,0.158,-2.3,11.8
ENSMUSG00000061315,NACA,nascent polypeptide-associated complex alpha subunit,nucleus|nucleus|cytoplasm|cytoplasm|nascent polypeptide-associated complex|extracellular vesicular exosome|,"cardiac ventricle development|transcription, DNA-templated|regulation of transcription, DNA-templated|translation|negative regulation of striated muscle cell apoptotic process|protein transport|viral process|skeletal muscle tissue regeneration|positive regulation of skeletal muscle tissue growth|regulation of skeletal muscle fiber development|heart trabecula morphogenesis|negative regulation of transcription from RNA polymerase II promoter involved in heart development|positive regulation of transcription from RNA polymerase II promoter involved in heart development|positive regulation of cell proliferation involved in heart morphogenesis|",DNA binding|transcription coactivator activity|protein binding|TBP-class protein binding|,10,-3.9,2.87,10,-1.2,1.64,-2.8,3.27,0.158,-7.4,5.3
ENSMUSG00000025503,TALDO1,transaldolase 1,nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,"carbohydrate metabolic process|xylulose biosynthetic process|fructose 6-phosphate metabolic process|pentose-phosphate shunt|energy reserve metabolic process|pentose-phosphate shunt, non-oxidative branch|glyceraldehyde-3-phosphate metabolic process|small molecule metabolic process|",sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|monosaccharide binding|,9,0,0,9,-5.9,5.46,-1.3,3.26,0.159,-11.5,-0.1
ENSMUSG00000042292,MKL1,megakaryoblastic leukemia (translocation) 1,nucleus|cytoplasm|,"transcription, DNA-templated|positive regulation of transcription via serum response element binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|negative regulation of apoptotic signaling pathway|",transcription regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|actin binding|actin monomer binding|protein binding|leucine zipper domain binding|,10,3.6,0.112,10,2.7,3.5,2.8,3.26,0.159,-4.8,7.4
ENSMUSG00000027381,BCL2L11,BCL2-like 11 (apoptosis facilitator),mitochondrial outer membrane|cytosol|cytosol|microtubule|endomembrane system|extrinsic component of membrane|BIM-BCL-xl complex|BIM-BCL-2 complex|,in utero embryonic development|B cell homeostasis|B cell apoptotic process|kidney development|myeloid cell homeostasis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell-matrix adhesion|spermatogenesis|brain development|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|mammary gland development|positive regulation of protein homooligomerization|response to endoplasmic reticulum stress|tube formation|odontogenesis of dentin-containing tooth|T cell homeostasis|positive regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|ear development|positive regulation of cell cycle|regulation of organ growth|neurotrophin TRK receptor signaling pathway|developmental pigmentation|regulation of developmental pigmentation|spleen development|thymus development|post-embryonic organ morphogenesis|positive regulation of apoptotic process by virus|cellular process regulating host cell cycle in response to virus|thymocyte apoptotic process|positive regulation of release of cytochrome c from mitochondria|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of mitochondrial membrane permeability involved in apoptotic process|apoptotic process involved in embryonic digit morphogenesis|positive regulation of fibroblast apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|microtubule binding|microtubule binding|,10,-5.1,1.32,10,-1.8,3.45,-1.9,3.26,0.159,-8.6,1
ENSMUSG00000009406,ELK1,"ELK1, member of ETS oncogene family",nucleus|nucleus|,"toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription from RNA polymerase II promoter|cell differentiation|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|stress-activated MAPK cascade|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|protein binding|,10,1.8,1.23,10,2.1,2.26,2,3.26,0.159,-1.1,5.6
ENSMUSG00000020010,VNN3,vanin 3,cellular_component|extracellular space|plasma membrane|anchored component of membrane|,biological_process|pantothenate metabolic process|,pantetheine hydrolase activity|,1,-2.3,0.878,1,-3.2,2.7,-3.1,3.25,0.16,-6,0.6
ENSMUSG00000073267,GM1993,predicted gene 1993,cellular_component|,biological_process|,molecular_function|,3,-4.9,4.75,4,3.9,3.66,-4.7,3.24,0.16,-10,6.2
ENSMUSG00000097100,9230104M06RIK,RIKEN cDNA 9230104M06 gene,None,None,None,0,0,0,1,-4.5,3.38,-4.5,3.23,0.161,-9,0.2
ENSMUSG00000011034,SLC5A1,"solute carrier family 5 (sodium/glucose cotransporter), member 1",plasma membrane|integral component of plasma membrane|cell-cell junction|apical plasma membrane|brush border membrane|extracellular vesicular exosome|,carbohydrate metabolic process|sodium ion transport|hexose transport|glucose transport|small molecule metabolic process|intestinal absorption|transmembrane transport|,glucose:sodium symporter activity|protein binding|,0,0,0,1,3.3,3.39,3.3,3.23,0.161,-0.5,7
ENSMUSG00000028172,TACR3,tachykinin receptor 3,nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|dendrite membrane|neuronal cell body membrane|,tachykinin receptor signaling pathway|aging|positive regulation of heart rate|response to estradiol|regulation of dopamine metabolic process|response to cocaine|hyperosmotic salinity response|response to morphine|positive regulation of blood pressure|regulation of feeding behavior|positive regulation of uterine smooth muscle contraction|,tachykinin receptor activity|protein binding|,10,-5.1,1.88,10,-1.9,3.65,-2,3.23,0.161,-8.7,3.3
ENSMUSG00000061723,TNNT3,"troponin T type 3 (skeletal, fast)",cytosol|troponin complex|,skeletal muscle contraction|ATP catabolic process|regulation of striated muscle contraction|muscle filament sliding|regulation of ATPase activity|,actin binding|tropomyosin binding|tropomyosin binding|troponin C binding|calcium-dependent ATPase activity|troponin I binding|calcium-dependent protein binding|,9,-6.3,3.57,10,-1.1,1.67,-1.3,3.23,0.161,-11.2,0.8
ENSMUSG00000020808,FAM64A,"family with sequence similarity 64, member A",nucleus|nucleolus|cytoplasm|,mitotic nuclear division|,protein binding|,9,2.6,5.62,8,-1.8,2.51,2.5,3.22,0.162,-5.2,5.7
ENSMUSG00000022018,RGCC,regulator of cell cycle,nucleus|cytoplasm|centrosome|,negative regulation of exit from mitosis|negative regulation of endothelial cell proliferation|positive regulation of extracellular matrix constituent secretion|complement activation|negative regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|negative regulation of angiogenesis|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|positive regulation of collagen biosynthetic process|negative regulation of blood vessel endothelial cell migration|positive regulation of mitosis|negative regulation of cytokine secretion|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of stress fiber assembly|positive regulation of cell cycle arrest|cellular response to hypoxia|mitotic cell cycle arrest|fibroblast activation|negative regulation of fibroblast growth factor production|positive regulation of gene expression involved in extracellular matrix organization|negative regulation of mitotic cell cycle phase transition|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of endothelial cell apoptotic process|positive regulation of DNA biosynthetic process|,protein binding|protein kinase binding|protein kinase binding|protein kinase activator activity|R-SMAD binding|,9,6.2,5.53,9,0.9,0.432,6.1,3.22,0.162,-1.8,13.6
ENSMUSG00000024973,HRASLS5,"HRAS-like suppressor family, member 5",None,metabolic process|,"transferase activity, transferring acyl groups|",0,0,0,1,-4.5,3.37,-4.5,3.22,0.162,-9,0.3
ENSMUSG00000022940,PIGP,"phosphatidylinositol glycan anchor biosynthesis, class P",glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|integral component of membrane|,C-terminal protein lipidation|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,phosphatidylinositol N-acetylglucosaminyltransferase activity|,1,-2.9,1.29,1,-2.9,2.13,-2.9,3.21,0.163,-6,0.6
ENSMUSG00000020048,HSP90B1,"heat shock protein 90kDa beta (Grp94), member 1",extracellular region|nucleus|endoplasmic reticulum|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|membrane|midbody|melanosome|perinuclear region of cytoplasm|extracellular vesicular exosome|endocytic vesicle lumen|,response to hypoxia|toll-like receptor signaling pathway|protein folding|activation of signaling protein activity involved in unfolded protein response|protein transport|ER-associated ubiquitin-dependent protein catabolic process|endoplasmic reticulum unfolded protein response|actin rod assembly|negative regulation of apoptotic process|negative regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|cellular protein metabolic process|innate immune response|sequestering of calcium ion|cellular response to ATP|,RNA binding|calcium ion binding|protein binding|ATP binding|protein phosphatase binding|virion binding|low-density lipoprotein particle receptor binding|unfolded protein binding|,9,6.3,5.91,10,-1,0.325,6.2,3.2,0.163,-1.1,13.7
ENSMUSG00000017776,CRK,v-crk avian sarcoma virus CT10 oncogene homolog,nucleus|cytoplasm|cytosol|plasma membrane|extracellular vesicular exosome|,activation of MAPKK activity|regulation of transcription from RNA polymerase II promoter|blood coagulation|insulin receptor signaling pathway|positive regulation of signal transduction|platelet activation|regulation of Rho GTPase activity|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|,SH3/SH2 adaptor activity|protein binding|SH2 domain binding|protein phosphorylated amino acid binding|ephrin receptor binding|,10,-1.8,0.509,10,-2.1,2.92,-1.9,3.19,0.164,-9.1,1.9
ENSMUSG00000019982,MYB,v-myb avian myeloblastosis viral oncogene homolog,nuclear matrix|,"G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|calcium ion transport|blood coagulation|B cell differentiation|positive regulation of T-helper cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|thymus development|embryonic digestive tract development|homeostasis of number of cells|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|protein binding|,10,-1.5,2.15,10,-1.3,1.31,-1.4,3.19,0.164,-5.9,2.5
ENSMUSG00000046058,EID2,EP300 interacting inhibitor of differentiation 2,intracellular|nucleus|,"transcription, DNA-templated|transforming growth factor beta receptor complex assembly|SMAD protein complex assembly|muscle organ development|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|negative regulation of transcription, DNA-templated|",protein binding|SMAD binding|,1,2.3,1.96,1,2.3,1.45,2.3,3.19,0.164,-0.8,5
ENSMUSG00000027699,ECT2,epithelial cell transforming 2,nucleus|cytoplasm|cytosol|cell-cell junction|tight junction|midbody|cleavage furrow|mitotic spindle|centralspindlin complex|,cell morphogenesis|cytokinesis|small GTPase mediated signal transduction|protein transport|activation of protein kinase activity|positive regulation of Rho GTPase activity|positive regulation of Rho GTPase activity|positive regulation of cytokinesis|positive regulation of cytokinesis|activation of Rho GTPase activity|activation of Rac GTPase activity|positive regulation of protein import into nucleus|positive regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of Cdc42 GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of neuron differentiation|regulation of protein kinase activity|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|protein homooligomerization|regulation of attachment of spindle microtubules to kinetochore|cellular response to hydrogen peroxide|tight junction assembly|cellular response to calcium ion|cellular response to ionizing radiation|apoptotic signaling pathway|,signal transducer activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|Rho GTPase binding|protein homodimerization activity|,6,-4.8,2.75,4,4.1,2.25,-2.8,3.19,0.164,-9.7,6.3
ENSMUSG00000096427,OLFR895,olfactory receptor 895,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-2.4,0.948,1,-3.1,2.53,-3,3.19,0.164,-6,0.6
ENSMUSG00000070372,CAPZA1,"capping protein (actin filament) muscle Z-line, alpha 1",extracellular region|cytosol|cytoskeleton|F-actin capping protein complex|actin cytoskeleton|extracellular vesicular exosome|WASH complex|,protein complex assembly|cellular component movement|blood coagulation|actin cytoskeleton organization|innate immune response|actin filament capping|,actin binding|protein binding|,0,0,0,1,3.3,3.32,3.3,3.17,0.166,-0.6,7
ENSMUSG00000038990,CABLES2,Cdk5 and Abl enzyme substrate 2,None,cell cycle|regulation of protein kinase activity|cell division|regulation of cell division|regulation of cell cycle|,cyclin-dependent protein serine/threonine kinase regulator activity|,9,-3.2,3.46,10,-0.4,0.36,-3.3,3.17,0.166,-8.1,1.6
ENSMUSG00000045538,DDX28,DEAD (Asp-Glu-Ala-Asp) box polypeptide 28,nucleus|mitochondrion|mitochondrial nucleoid|,metabolic process|,helicase activity|ATP binding|poly(A) RNA binding|,1,3.1,3.32,0,0,0,3.1,3.17,0.166,-0.6,7
ENSMUSG00000028300,3110043O21RIK,RIKEN cDNA 3110043O21 gene,extracellular region|extracellular space|extracellular space|nucleus|nucleus|cytoplasm|lysosome|endosome|autophagic vacuole|cytoplasmic vesicle|,endocytosis|autophagy|,protein binding|Rab GTPase binding|Rab GTPase binding|,1,3.3,3.61,1,0.6,0.138,3.2,3.17,0.166,-0.5,7
ENSMUSG00000017615,TNFAIP1,"tumor necrosis factor, alpha-induced protein 1 (endothelial)",nucleolus|cytoplasm|endosome|Cul3-RING ubiquitin ligase complex|,DNA replication|apoptotic process|immune response|embryo development|cell migration|protein ubiquitination|protein ubiquitination|negative regulation of Rho protein signal transduction|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|protein homooligomerization|,ubiquitin-protein transferase activity|protein binding|GTP-Rho binding|protein domain specific binding|,9,-2.7,2.3,10,-0.9,1.99,-3.1,3.16,0.166,-8.9,0.6
ENSMUSG00000027523,GNAS,GNAS complex locus,ruffle|extracellular region|nucleus|cytoplasm|cytosol|cytosol|heterotrimeric G-protein complex|heterotrimeric G-protein complex|heterotrimeric G-protein complex|plasma membrane|plasma membrane|membrane|membrane|transport vesicle|dendrite|intrinsic component of membrane|trans-Golgi network membrane|perinuclear region of cytoplasm|extracellular vesicular exosome|,tissue homeostasis|endochondral ossification|energy reserve metabolic process|energy reserve metabolic process|cAMP biosynthetic process|GTP catabolic process|DNA methylation|water transport|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|female pregnancy|blood coagulation|sensory perception of chemical stimulus|sensory perception of smell|protein secretion|positive regulation of cAMP biosynthetic process|positive regulation of Ras GTPase activity|embryonic hindlimb morphogenesis|multicellular organism growth|negative regulation of multicellular organism growth|post-embryonic body morphogenesis|response to drug|positive regulation of cAMP-mediated signaling|small molecule metabolic process|positive regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|intracellular transport|developmental growth|developmental growth|embryonic cranial skeleton morphogenesis|regulation of insulin secretion|cognition|cognition|cartilage development|transmembrane transport|bone development|bone development|hair follicle placode formation|hair follicle placode formation|platelet aggregation|platelet aggregation|response to parathyroid hormone|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|genetic imprinting|cellular response to catecholamine stimulus|adenylate cyclase-activating adrenergic receptor signaling pathway|,molecular_function|GTPase activity|GTPase activity|adenylate cyclase activity|signal transducer activity|signal transducer activity|insulin-like growth factor receptor binding|protein binding|GTP binding|G-protein beta/gamma-subunit complex binding|G-protein beta/gamma-subunit complex binding|beta-2 adrenergic receptor binding|D1 dopamine receptor binding|mu-type opioid receptor binding|ionotropic glutamate receptor binding|metal ion binding|corticotropin-releasing hormone receptor 1 binding|,10,0.9,0.731,10,-2,5.22,-1.8,3.16,0.166,-6,1.7
ENSMUSG00000049504,PROSER1,proline and serine rich 1,None,None,None,1,-2.3,0.901,1,-3.1,2.56,-3,3.15,0.167,-6,0.6
ENSMUSG00000020686,GAS2L2,growth arrest-specific 2 like 2,stress fiber|cytoplasm|cytoplasm|cytoskeleton|microtubule|,microtubule bundle formation|negative regulation of microtubule depolymerization|cell cycle arrest|,microtubule binding|cytoskeletal adaptor activity|actin filament binding|,10,-2.8,3.15,10,-1.2,1.47,-2.4,3.15,0.167,-7.4,2.2
ENSMUSG00000020682,MMP28,matrix metallopeptidase 28,proteinaceous extracellular matrix|,proteolysis|,metalloendopeptidase activity|calcium ion binding|zinc ion binding|,0,0,0,1,-3.9,3.3,-3.9,3.15,0.167,-7,0.6
ENSMUSG00000032085,TAGLN,transgelin,cytoplasm|,muscle organ development|epithelial cell differentiation|,actin binding|protein binding|,10,-2.1,1.46,10,-1,2.31,-1,3.15,0.167,-8.2,1.1
ENSMUSG00000022797,TFRC,transferrin receptor,extracellular region|extracellular space|endosome|plasma membrane|integral component of plasma membrane|coated pit|external side of plasma membrane|cell surface|membrane|cytoplasmic membrane-bounded vesicle|melanosome|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|extracellular vesicular exosome|blood microparticle|,proteolysis|cellular iron ion homeostasis|cellular iron ion homeostasis|receptor-mediated endocytosis|receptor-mediated endocytosis|viral process|osteoclast differentiation|transferrin transport|positive regulation of bone resorption|transmembrane transport|iron ion import|,double-stranded RNA binding|transferrin receptor activity|protein binding|peptidase activity|identical protein binding|poly(A) RNA binding|,10,-5.4,5.23,10,-1.1,0.891,-4.5,3.15,0.167,-10.3,2.6
ENSMUSG00000024669,CD5,CD5 molecule,plasma membrane|integral component of plasma membrane|external side of plasma membrane|,receptor-mediated endocytosis|cell recognition|cell proliferation|T cell costimulation|apoptotic signaling pathway|,receptor activity|transmembrane signaling receptor activity|scavenger receptor activity|protein binding|,10,-3.3,3.82,10,-1.3,0.853,-2.9,3.15,0.167,-8,2.1
ENSMUSG00000053279,ALDH1A1,"aldehyde dehydrogenase 1 family, member A1",cytoplasm|cytosol|extracellular vesicular exosome|,ethanol oxidation|cellular aldehyde metabolic process|xenobiotic metabolic process|positive regulation of Ras GTPase activity|retinol metabolic process|small molecule metabolic process|,retinal dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|Ras GTPase activator activity|androgen binding|,10,-2.6,2.75,10,-0.7,1.05,-3.7,3.14,0.168,-9.1,2.8
ENSMUSG00000040197,CD209E,CD209e antigen,membrane|integral component of membrane|extracellular vesicular exosome|,endocytosis|biological_process|,mannose binding|carbohydrate binding|,0,0,0,1,-4,3.29,-4,3.14,0.168,-7,0.6
ENSMUSG00000028018,GSTCD,"glutathione S-transferase, C-terminal domain containing",extracellular vesicular exosome|,biological_process|,molecular_function|protein binding|,0,0,0,1,-4.4,3.29,-4.4,3.14,0.168,-8,0.5
ENSMUSG00000078346,GM5132,predicted gene 5132,nucleosome|cellular_component|nucleus|chromosome|,biological_process|,molecular_function|DNA binding|,0,0,0,1,-3.9,3.3,-3.9,3.14,0.168,-7,0.6
ENSMUSG00000005417,MPRIP,myosin phosphatase Rho interacting protein,cytoplasm|actin cytoskeleton|,None,actin binding|protein binding|,0,0,0,1,-3.9,3.29,-3.9,3.14,0.168,-7,0.6
ENSMUSG00000071177,SERPINA1D,"serine (or cysteine) peptidase inhibitor, clade A, member 1D",extracellular region|extracellular space|endoplasmic reticulum|Golgi apparatus|extracellular vesicular exosome|,negative regulation of peptidase activity|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|regulation of proteolysis|response to cytokine|response to peptide hormone|,glycoprotein binding|protease binding|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|peptidase inhibitor activity|identical protein binding|,0,0,0,1,-4,3.29,-4,3.14,0.168,-7,0.6
ENSMUSG00000040183,ANKRD6,ankyrin repeat domain 6,nucleus|cytoplasm|,"positive regulation of JNK cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway|",None,0,0,0,1,-4,3.29,-4,3.14,0.168,-8,0.4
ENSMUSG00000058672,TUBB2A,"tubulin, beta 2A class IIa",nucleus|cytoplasm|microtubule|extracellular vesicular exosome|,GTP catabolic process|protein folding|microtubule-based process|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|GTP binding|,10,-3.9,0.832,10,-3.3,2.61,-3.6,3.14,0.168,-8.2,0.3
ENSMUSG00000003575,CRTC1,CREB regulated transcription coactivator 1,nucleus|cytoplasm|plasma membrane|,"transcription, DNA-templated|viral process|positive regulation of CREB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein homotetramerization|",protein binding|cAMP response element binding protein binding|,10,0.5,0.198,10,-3.3,4.8,-2.4,3.14,0.168,-7.6,1.2
ENSMUSG00000035711,DOK3,docking protein 3,cytoplasm|plasma membrane|,Ras protein signal transduction|,insulin receptor binding|protein binding|,0,0,0,1,-4,3.28,-4,3.13,0.169,-8,0.4
ENSMUSG00000056665,THEM6,thioesterase superfamily member 6,extracellular region|,None,None,1,-2.1,0.783,1,-3.2,2.7,-3.1,3.13,0.169,-6,0.6
ENSMUSG00000028496,MLLT3,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3",nucleus|extracellular vesicular exosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|segment specification|anterior/posterior pattern specification|negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway|",protein binding|,10,-3.1,4.7,9,2.1,1.52,-2.8,3.13,0.169,-6.8,4.9
ENSMUSG00000021270,HSP90AA1,"heat shock protein 90kDa alpha (cytosolic), class A member 1",extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|cytosol|plasma membrane|membrane|melanosome|extracellular vesicular exosome|endocytic vesicle lumen|,G2/M transition of mitotic cell cycle|mitotic cell cycle|ATP catabolic process|mitochondrial transport|response to unfolded protein|signal transduction|axon guidance|Fc-gamma receptor signaling pathway involved in phagocytosis|protein refolding|small molecule metabolic process|protein import into mitochondrial outer membrane|innate immune response|positive regulation of nitric oxide biosynthetic process|nitric oxide metabolic process|regulation of nitric-oxide synthase activity|chaperone-mediated protein complex assembly|,nucleotide binding|protein binding|ATP binding|ATPase activity|MHC class II protein complex binding|nitric-oxide synthase regulator activity|TPR domain binding|TPR domain binding|identical protein binding|protein homodimerization activity|poly(A) RNA binding|unfolded protein binding|,9,-3.6,2.12,10,-1.7,1.57,-1.7,3.13,0.169,-7.1,3.1
ENSMUSG00000022360,ATAD2,"ATPase family, AAA domain containing 2",nucleus|extracellular vesicular exosome|,"ATP catabolic process|transcription, DNA-templated|positive regulation of transcription, DNA-templated|",ATP binding|ATPase activity|,0,0,0,1,-3.7,3.28,-3.7,3.13,0.169,-7,0.6
ENSMUSG00000024177,NME4,NME/NM23 nucleoside diphosphate kinase 4,mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|,nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|nucleoside metabolic process|nucleobase-containing small molecule interconversion|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,nucleoside diphosphate kinase activity|protein binding|ATP binding|protein complex binding|metal ion binding|,0,0,0,1,3.3,3.29,3.3,3.13,0.169,-0.6,7
ENSMUSG00000051279,GDF6,growth differentiation factor 6,extracellular space|,"apoptotic process|positive regulation of pathway-restricted SMAD protein phosphorylation|BMP signaling pathway|activin receptor signaling pathway|growth|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|pathway-restricted SMAD protein phosphorylation|retinal cell apoptotic process|",cytokine activity|growth factor activity|protein homodimerization activity|,10,-1.1,0.22,10,-2.2,3.35,-1.5,3.13,0.169,-4.3,0.5
ENSMUSG00000007207,STX1A,syntaxin 1A (brain),extracellular region|plasma membrane|integral component of membrane|cell junction|secretory granule|synaptic vesicle membrane|SNARE complex|actomyosin|neuron projection|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|,positive regulation of neurotransmitter secretion|energy reserve metabolic process|intracellular protein transport|synaptic transmission|neurotransmitter secretion|response to gravity|glutamate secretion|synaptic vesicle docking involved in exocytosis|calcium ion-dependent exocytosis|cellular protein metabolic process|small molecule metabolic process|positive regulation of exocytosis|regulation of insulin secretion|,"SNARE binding|glycoprotein binding|SNAP receptor activity|protein binding|calcium channel inhibitor activity|protein domain specific binding|protein binding, bridging|myosin head/neck binding|ATP-dependent protein binding|protein heterodimerization activity|protein N-terminus binding|calcium-dependent protein binding|",1,-5.2,2.7,1,-2.5,1.11,-5,3.13,0.169,-10,0
ENSMUSG00000015747,VPS45,vacuolar protein sorting 45 homolog (S. cerevisiae),Golgi membrane|cellular_component|Golgi apparatus|endosome membrane|integral component of membrane|,intracellular protein transport|vesicle docking involved in exocytosis|blood coagulation|,molecular_function|,9,-1.2,0.264,9,-3.5,3.64,-2.8,3.12,0.169,-8.2,1.9
ENSMUSG00000070426,RNF121,ring finger protein 121,integral component of membrane|,None,zinc ion binding|,1,-6.1,2.65,1,3.5,3.75,3.5,3.12,0.169,-10.8,7
ENSMUSG00000038770,KPNA7,karyopherin alpha 7 (importin alpha 8),nucleoplasm|cytosol|,protein import into nucleus|cytokine-mediated signaling pathway|,protein transporter activity|,1,3.1,3.26,0,0,0,3.1,3.11,0.17,-0.6,7
ENSMUSG00000031788,KIFC3,kinesin family member C3,Golgi apparatus|centrosome|kinesin complex|microtubule|zonula adherens|cytoplasmic vesicle membrane|extracellular vesicular exosome|,microtubule-based movement|Golgi organization|visual perception|metabolic process|metabolic process|zonula adherens maintenance|epithelial cell-cell adhesion|,microtubule motor activity|ATP binding|microtubule binding|,0,0,0,1,-4.3,3.27,-4.3,3.11,0.17,-8,0.5
ENSMUSG00000039016,TIMM8B,translocase of inner mitochondrial membrane 8 homolog B (yeast),extracellular space|mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex|,protein targeting to mitochondrion|sensory perception of sound|cellular protein metabolic process|chaperone-mediated protein transport|,zinc ion binding|,0,0,0,1,-4.3,3.27,-4.3,3.11,0.17,-8,0.5
ENSMUSG00000038291,SNX25,sorting nexin 25,cellular_component|endosome membrane|,protein transport|negative regulation of transforming growth factor beta receptor signaling pathway|receptor catabolic process|termination of G-protein coupled receptor signaling pathway|negative regulation of pathway-restricted SMAD protein phosphorylation|,molecular_function|phosphatidylinositol binding|,0,0,0,1,-4.3,3.27,-4.3,3.11,0.17,-8,0.5
ENSMUSG00000043831,LYSMD4,"LysM, putative peptidoglycan-binding, domain containing 4",integral component of membrane|,None,None,0,0,0,1,-3.7,3.25,-3.7,3.1,0.171,-7,0.6
ENSMUSG00000040225,PRRC2C,proline-rich coiled-coil 2C,membrane|,None,protein C-terminus binding|poly(A) RNA binding|,0,0,0,1,3.3,3.25,3.3,3.1,0.171,-0.6,7
ENSMUSG00000042279,H1FOO,"H1 histone family, member O, oocyte-specific",nucleosome|female germ cell nucleus|nucleus|cytoplasm|extracellular vesicular exosome|,nucleosome assembly|meiotic nuclear division|nucleosome positioning|regulation of DNA methylation|negative regulation of stem cell differentiation|,nucleosomal DNA binding|,0,0,0,1,3.3,3.25,3.3,3.1,0.171,-0.6,7
ENSMUSG00000016150,TENM1,teneurin transmembrane protein 1,extracellular region|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|nuclear matrix|nuclear speck|perinuclear region of cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase III promoter|response to stress|immune response|neuropeptide signaling pathway|nervous system development|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|positive regulation of MAP kinase activity|positive regulation of filopodium assembly|positive regulation of intracellular protein transport|",heparin binding|protein homodimerization activity|protein heterodimerization activity|,9,-1.8,2.28,10,-1.4,1.18,-1.6,3.1,0.171,-4.8,1.9
ENSMUSG00000042514,KLHL14,kelch-like family member 14,endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|neuron projection|neuronal cell body|,None,None,0,0,0,2,3.6,3.25,3.6,3.1,0.171,-1.6,7
ENSMUSG00000032657,FAM189B,"family with sequence similarity 189, member B",integral component of membrane|,biological_process|,protein binding|WW domain binding|,0,0,0,1,3.3,3.25,3.3,3.1,0.171,-0.6,7
ENSMUSG00000027522,STX16,syntaxin 16,Golgi membrane|nucleolus|cytoplasm|Golgi apparatus|integral component of membrane|SNARE complex|SNARE complex|intracellular membrane-bounded organelle|,"intracellular protein transport|intra-Golgi vesicle-mediated transport|retrograde transport, endosome to Golgi|",SNAP receptor activity|protein binding|,0,0,0,1,3.3,3.25,3.3,3.1,0.171,-0.6,7
ENSMUSG00000049133,FLG2,filaggrin family member 2,nucleus|cytoplasm|extracellular vesicular exosome|,establishment of skin barrier|,structural molecule activity|calcium ion binding|,0,0,0,1,-4.3,3.26,-4.3,3.1,0.171,-8,0.5
ENSMUSG00000070841,VMN2R34,"vomeronasal 2, receptor 34",cellular_component|plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|biological_process|,molecular_function|signal transducer activity|G-protein coupled receptor activity|,5,-3.3,1.23,5,5.4,5.22,5.3,3.09,0.171,-3.5,11
ENSMUSG00000022002,4930564B18RIK,RIKEN cDNA 4930564B18 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,2,-2.9,3.24,-2.9,3.09,0.171,-6,0.6
ENSMUSG00000046561,ARSJ,"arylsulfatase family, member J",extracellular region|endoplasmic reticulum lumen|,sphingolipid metabolic process|glycosphingolipid metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|,arylsulfatase activity|metal ion binding|,8,-0.8,0.576,8,-2,3.29,-1.6,3.09,0.171,-6.3,1.8
ENSMUSG00000071337,TIA1,TIA1 cytotoxic granule-associated RNA binding protein,cytoplasmic stress granule|nuclear stress granule|,"apoptotic process|negative regulation of translation|negative regulation of cytokine biosynthetic process|regulation of mRNA splicing, via spliceosome|",nucleotide binding|protein binding|poly(A) binding|AU-rich element binding|poly(A) RNA binding|,10,-2.8,1.31,10,-4,2.22,-3.2,3.09,0.171,-10,2
ENSMUSG00000045216,HS6ST1,heparan sulfate 6-O-sulfotransferase 1,Golgi membrane|integral component of plasma membrane|,"angiogenesis|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|glycosaminoglycan metabolic process|small molecule metabolic process|lung alveolus development|neuron development|labyrinthine layer blood vessel development|",sulfotransferase activity|,10,1.3,1.49,10,-1.7,2.43,-1.6,3.09,0.171,-5.6,4
ENSMUSG00000058755,OSM,oncostatin M,extracellular space|oncostatin-M receptor complex|,positive regulation of acute inflammatory response|immune response|multicellular organismal development|peripheral nervous system development|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|response to heat|positive regulation of peptidyl-serine phosphorylation|regulation of growth|tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat1 protein|positive regulation of MAPK cascade|negative regulation of meiosis|positive regulation of transcription from RNA polymerase II promoter|negative regulation of hormone secretion|behavioral response to pain|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|positive regulation of apoptotic signaling pathway|,cytokine activity|oncostatin-M receptor binding|growth factor activity|,10,-2.5,3.48,10,-0.8,0.808,-2.2,3.08,0.172,-5.7,2.3
ENSMUSG00000027799,NBEA,neurobeachin,trans-Golgi network|cytosol|plasma membrane|endomembrane system|,protein localization|,protein kinase binding|,1,-1.7,0.664,1,-3.3,2.84,-3.2,3.08,0.172,-6,0.6
ENSMUSG00000089989,FLT3L,FMS-like tyrosine kinase 3 ligand,extracellular region|extracellular space|plasma membrane|cell surface|membrane|integral component of membrane|intrinsic component of external side of plasma membrane|,positive regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of cell proliferation|phosphorylation|lymphocyte differentiation|regulation of myeloid dendritic cell activation|positive regulation of natural killer cell differentiation|embryonic hemopoiesis|,cytokine activity|kinase activity|transferase activity|receptor tyrosine kinase binding|receptor tyrosine kinase binding|protein homodimerization activity|,9,-2.8,1.92,9,-3.2,1.46,-3,3.08,0.172,-8.5,0.9
ENSMUSG00000040612,ILDR2,immunoglobulin-like domain containing receptor 2,endoplasmic reticulum membrane|integral component of membrane|,response to glucose|insulin secretion|cell differentiation|pancreas development|homeostasis of number of cells within a tissue|,None,0,0,0,1,-3.6,3.23,-3.6,3.08,0.172,-7,0.6
ENSMUSG00000009248,ASCL2,achaete-scute family bHLH transcription factor 2,nucleus|nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|response to hypoxia|placenta development|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of Schwann cell proliferation|somatic stem cell maintenance|spongiotrophoblast differentiation|spongiotrophoblast layer development|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|protein dimerization activity|E-box binding|,0,0,0,1,-3.6,3.22,-3.6,3.07,0.173,-7,0.6
ENSMUSG00000078813,LENG1,leukocyte receptor cluster (LRC) member 1,cellular_component|,biological_process|,molecular_function|,10,-3.8,5.79,10,2.6,2.95,-3.7,3.07,0.173,-7,4
ENSMUSG00000040785,TTC3,tetratricopeptide repeat domain 3,nucleus|mitochondrion|vacuole|,ubiquitin-dependent protein catabolic process|negative regulation of cell morphogenesis involved in differentiation|negative regulation of neuron differentiation|protein K48-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,10,-2.5,3.37,10,-0.8,0.592,-2.3,3.07,0.173,-5.7,2
ENSMUSG00000042195,SLC35F2,"solute carrier family 35, member F2",cellular_component|integral component of membrane|,transport|biological_process|,molecular_function|,0,0,0,1,-3.6,3.22,-3.6,3.07,0.173,-7,0.6
ENSMUSG00000070448,VMN2R89,"vomeronasal 2, receptor 89",cellular_component|membrane|integral component of membrane|,biological_process|,molecular_function|,10,3.7,4.9,10,0.9,0.465,3.4,3.07,0.173,-1.6,10.7
ENSMUSG00000014873,SURF2,surfeit 2,cellular_component|nucleus|nucleolus|plasma membrane|,biological_process|,molecular_function|,1,-2.4,0.959,2,3.2,2.53,-3.8,3.06,0.173,-7,5.9
ENSMUSG00000022952,RUNX1,runt-related transcription factor 1,basement membrane|nucleus|nucleus|,"skeletal system development|in utero embryonic development|liver development|myeloid progenitor cell differentiation|transcription, DNA-templated|central nervous system development|regulation of signal transduction|hemopoiesis|hemopoiesis|myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of granulocyte differentiation|hair follicle morphogenesis|embryonic hemopoiesis|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|behavioral response to pain|peripheral nervous system neuron development|definitive hemopoiesis|regulation of hair follicle cell proliferation|hematopoietic stem cell proliferation|positive regulation of progesterone secretion|",regulatory region DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|calcium ion binding|protein binding|ATP binding|transcription factor binding|protein homodimerization activity|protein heterodimerization activity|repressing transcription factor binding|,9,-2.2,4.91,9,0.9,0.384,-2.1,3.06,0.173,-7.1,2.4
ENSMUSG00000024511,RAB27B,"RAB27B, member RAS oncogene family",Golgi stack|apical plasma membrane|trans-Golgi network transport vesicle|multivesicular body membrane|zymogen granule membrane|extracellular vesicular exosome|,GTP catabolic process|small GTPase mediated signal transduction|protein transport|positive regulation of exocytosis|multivesicular body sorting pathway|,GTPase activity|GTP binding|GTP binding|GDP binding|protein domain specific binding|,0,0,0,1,3.3,3.21,3.3,3.06,0.173,-0.6,7
ENSMUSG00000051391,YWHAG,"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma",cytosol|membrane|cytoplasmic vesicle membrane|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|negative regulation of protein kinase activity|protein targeting|apoptotic process|regulation of signal transduction|cellular response to insulin stimulus|regulation of neuron differentiation|regulation of synaptic plasticity|membrane organization|negative regulation of protein serine/threonine kinase activity|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|,protein kinase C binding|insulin-like growth factor receptor binding|protein binding|protein kinase C inhibitor activity|protein domain specific binding|receptor tyrosine kinase binding|poly(A) RNA binding|,0,0,0,1,3.3,3.21,3.3,3.06,0.173,-0.6,7
ENSMUSG00000025969,NRP2,neuropilin 2,semaphorin receptor complex|extracellular region|plasma membrane|membrane|integral component of membrane|axon|,angiogenesis|neural crest cell migration|positive regulation of endothelial cell proliferation|cell adhesion|axon guidance|axon guidance|heart development|positive regulation of endothelial cell migration|nerve development|vascular endothelial growth factor signaling pathway|vascular endothelial growth factor receptor signaling pathway|axon extension involved in axon guidance|negative chemotaxis|sympathetic ganglion development|sympathetic neuron projection extension|sympathetic neuron projection guidance|semaphorin-plexin signaling pathway involved in neuron projection guidance|,receptor activity|vascular endothelial growth factor-activated receptor activity|heparin binding|semaphorin receptor activity|growth factor binding|cytokine binding|metal ion binding|,10,-1.4,2.73,10,-1.5,0.518,-1.4,3.06,0.173,-5.3,6.8
ENSMUSG00000024033,RSPH1,radial spoke head 1 homolog (Chlamydomonas),nucleus|cytosol|motile cilium|,meiotic nuclear division|axoneme assembly|,None,10,-1.4,1.5,10,-3.9,1.78,-3.7,3.05,0.174,-8.6,0.9
ENSMUSG00000038774,ASCC3,activating signal cointegrator 1 complex subunit 3,intracellular|nucleus|cytoplasm|Golgi apparatus|membrane|,"DNA dealkylation involved in DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|cell proliferation|DNA duplex unwinding|",protein binding|ATP binding|ATP-dependent 3'-5' DNA helicase activity|poly(A) RNA binding|,10,-3.8,1.97,10,4.6,4.18,2.6,3.05,0.174,-6.2,9.1
ENSMUSG00000022636,ALCAM,activated leukocyte cell adhesion molecule,external side of plasma membrane|integral component of membrane|axon|neuronal cell body|extracellular vesicular exosome|,cell adhesion|signal transduction|axon guidance|motor neuron axon guidance|,receptor binding|,10,2.2,1.88,10,1.4,1.62,1.5,3.04,0.175,-2,7.5
ENSMUSG00000033004,MYCBP2,"MYC binding protein 2, E3 ubiquitin protein ligase",nucleus|microtubule cytoskeleton|membrane|axon|,"transcription, DNA-templated|regulation of transcription, DNA-templated|protein ubiquitination|branchiomotor neuron axon guidance|central nervous system projection neuron axonogenesis|regulation of protein localization|regulation of cytoskeleton organization|",ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|protein homodimerization activity|,10,-7.2,2.85,10,-1.5,1.06,-1.6,3.04,0.175,-12.7,3.5
ENSMUSG00000055602,TCP10B,t-complex protein 10b,None,None,None,10,-1.7,0.0881,10,-1.6,3.12,-1.6,3.04,0.175,-6.2,3.5
ENSMUSG00000015721,NLRP5,"NLR family, pyrin domain containing 5",nucleolus|mitochondrion|cytosol|protein complex|apical cortex|,in utero embryonic development|embryo implantation|fertilization|organ morphogenesis|regulation of protein stability|regulation of RNA stability|cellular protein complex assembly|neuron death|,ATP binding|,10,-3.5,2.87,10,2.3,3.35,2.8,3.04,0.175,-6.5,7.5
ENSMUSG00000028580,PUM1,pumilio RNA-binding family member 1,cytosol|,regulation of translation|post-Golgi vesicle-mediated transport|membrane organization|,poly(A) RNA binding|,0,0,0,1,-3.6,3.19,-3.6,3.04,0.175,-7,0.6
ENSMUSG00000050556,KCNB1,"potassium voltage-gated channel, Shab-related subfamily, member 1",plasma membrane|voltage-gated potassium channel complex|dendrite|dendrite membrane|neuronal cell body membrane|postsynaptic membrane|,energy reserve metabolic process|synaptic transmission|regulation of ion transmembrane transport|small molecule metabolic process|regulation of insulin secretion|protein homooligomerization|potassium ion transmembrane transport|,delayed rectifier potassium channel activity|protein binding|outward rectifier potassium channel activity|protein N-terminus binding|,10,-1.4,1.03,10,-5.4,2.51,-1.2,3.04,0.175,-9.9,5.2
ENSMUSG00000031262,CENPI,centromere protein I,kinetochore|nucleoplasm|cytosol|,mitotic cell cycle|nucleosome assembly|sex differentiation|centromere-specific nucleosome assembly|,protein binding|,7,4.3,3.87,6,-1.7,1.26,-2.2,3.04,0.175,-5.3,8
ENSMUSG00000026828,GALNT5,polypeptide N-acetylgalactosaminyltransferase 5,Golgi membrane|cellular_component|integral component of membrane|,glycosaminoglycan biosynthetic process|O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,-4.3,1.24,10,2.2,3.25,2.1,3.04,0.175,-6.9,5.2
ENSMUSG00000001039,B9D1,B9 protein domain 1,cytoplasm|centrosome|membrane|ciliary transition zone|TCTN-B9D complex|ciliary basal body|,in utero embryonic development|smoothened signaling pathway|regulation of protein localization|cardiocyte differentiation|cilium assembly|embryonic digit morphogenesis|camera-type eye development|cilium morphogenesis|neuroepithelial cell differentiation|,hedgehog receptor activity|,0,0,0,1,-3.6,3.19,-3.6,3.04,0.175,-7,0.6
ENSMUSG00000021209,PPP4R4,"protein phosphatase 4, regulatory subunit 4",cytoplasm|protein serine/threonine phosphatase complex|,negative regulation of phosphoprotein phosphatase activity|regulation of protein serine/threonine phosphatase activity|,protein binding|protein phosphatase regulator activity|,10,0,0,10,2.3,4.9,1.8,3.03,0.176,-3.7,6.1
ENSMUSG00000031832,TAF1C,"TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa",nucleoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|gene expression|",DNA binding|protein binding|,10,-2.7,1.31,10,-4,2.19,-3,3.03,0.176,-7.5,0.5
ENSMUSG00000045092,S1PR1,sphingosine-1-phosphate receptor 1,endosome|plasma membrane|external side of plasma membrane|integral component of membrane|intrinsic component of plasma membrane|membrane raft|,angiogenesis|blood vessel maturation|cardiac muscle tissue growth involved in heart morphogenesis|sphingosine-1-phosphate signaling pathway|chemotaxis|cell adhesion|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|brain development|cell migration|transmission of nerve impulse|lamellipodium assembly|regulation of cell adhesion|neuron differentiation|positive regulation of cell migration|regulation of bone mineralization|actin cytoskeleton reorganization|positive regulation of Ras GTPase activity|regulation of bone resorption|endothelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of smooth muscle cell proliferation|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|negative regulation of stress fiber assembly|heart trabecula morphogenesis|T cell migration|,G-protein coupled receptor binding|G-protein coupled receptor activity|sphingosine-1-phosphate receptor activity|sphingolipid binding|,10,2.4,2.64,10,0.9,1.5,1.1,3.03,0.176,-2.1,7
ENSMUSG00000041684,BIVM,"basic, immunoglobulin-like variable motif containing",extracellular space|nucleus|cytoplasm|,None,None,10,1.7,1.69,10,-1.8,2.45,-2.3,3.03,0.176,-9.4,5.5
ENSMUSG00000030035,WBP1,WW domain binding protein 1,cellular_component|,biological_process|,protein binding|WW domain binding|WW domain binding|,10,-2.8,3.26,10,-1.1,1.11,-2.5,3.02,0.176,-7.5,1.3
ENSMUSG00000041238,RBBP8,retinoblastoma binding protein 8,nucleus|nucleolus|transcriptional repressor complex|,"cell cycle checkpoint|G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|blastocyst hatching|DNA repair|regulation of transcription from RNA polymerase II promoter|mitotic nuclear division|meiotic nuclear division|DNA double-strand break processing involved in repair via single-strand annealing|G2 DNA damage checkpoint|",single-stranded DNA endodeoxyribonuclease activity|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity|damaged DNA binding|protein binding|,9,-3,2.67,9,1.9,1.17,-1.5,3.01,0.177,-5.9,2.7
ENSMUSG00000056124,B4GALT6,"UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6",Golgi membrane|integral component of membrane|Golgi cisterna membrane|,carbohydrate metabolic process|keratan sulfate biosynthetic process|protein N-linked glycosylation via asparagine|glycosaminoglycan metabolic process|keratan sulfate metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|,galactosyltransferase activity|metal ion binding|,10,-3.5,4.31,10,-0.4,0.174,-3.2,3.01,0.177,-9.4,3.6
ENSMUSG00000078144,CAPNS2,"calpain, small subunit 2",cytoplasm|plasma membrane|,proteolysis|,calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|,8,-2.5,2.18,8,-1.8,1.34,-2.2,3.01,0.177,-8.4,3
ENSMUSG00000040034,NUP43,nucleoporin 43kDa,kinetochore|condensed chromosome kinetochore|nuclear envelope|cytosol|nuclear pore outer ring|nuclear pore outer ring|,mitotic cell cycle|carbohydrate metabolic process|chromosome segregation|mitotic nuclear division|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|mRNA transport|transmembrane transport|,protein binding|,0,0,0,1,-3.5,3.15,-3.5,3,0.178,-7,0.6
ENSMUSG00000067567,HDAC8,histone deacetylase 8,histone deacetylase complex|nuclear chromosome|nucleus|cytoplasm|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|chromatin assembly or disassembly|transcription, DNA-templated|sister chromatid cohesion|chromatin modification|histone H3 deacetylation|histone H4 deacetylation|regulation of cohesin localization to chromatin|",histone deacetylase activity|transcription factor binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,-4.2,3.97,10,-1.3,0.564,-3.8,3,0.178,-10.4,0.5
ENSMUSG00000020430,PES1,pescadillo ribosomal biogenesis factor 1,"condensed chromosome|nucleoplasm|nucleolus|cytoplasm|membrane|preribosome, large subunit precursor|PeBoW complex|","maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing|nucleolus organization|cell proliferation|cell proliferation|protein localization to organelle|ribosomal large subunit biogenesis|regulation of cell cycle|",protein binding|ribonucleoprotein complex binding|poly(A) RNA binding|,5,2,1.18,7,-1.9,2.92,2.4,2.99,0.179,-4.2,6.4
ENSMUSG00000028999,RINT1,RAD50 interactor 1,endoplasmic reticulum|endoplasmic reticulum membrane|,protein transport|vesicle-mediated transport|G2 DNA damage checkpoint|,protein binding|,10,-3.7,3.03,10,-1.2,1.05,-1.8,2.99,0.179,-8.7,2.1
ENSMUSG00000016327,ATP1B4,"ATPase, Na+/K+ transporting, beta 4 polypeptide",nuclear inner membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|transport|monovalent inorganic cation transport|",monovalent inorganic cation transmembrane transporter activity|,0,0,0,1,3.2,3.14,3.2,2.99,0.179,-0.8,6
ENSMUSG00000035458,TNNI3,troponin I type 3 (cardiac),cytosol|troponin complex|sarcomere|,vasculogenesis|regulation of systemic arterial blood pressure by ischemic conditions|cellular calcium ion homeostasis|regulation of smooth muscle contraction|heart development|muscle filament sliding|negative regulation of ATPase activity|negative regulation of ATPase activity|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|,actin binding|protein binding|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|troponin C binding|troponin T binding|metal ion binding|calcium-dependent protein binding|,10,-4.9,4.03,10,-1.7,0.42,-3,2.99,0.179,-9.6,2.2
ENSMUSG00000006715,GMNN,"geminin, DNA replication inhibitor",nucleus|nucleoplasm|cytoplasm|cytosol|,"mitotic cell cycle|protein complex assembly|negative regulation of DNA replication|organ morphogenesis|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|",transcription corepressor activity|protein binding|histone deacetylase binding|repressing transcription factor binding|,9,2.5,2.16,8,4.7,1.75,2.9,2.99,0.179,-3.8,8.6
ENSMUSG00000050751,PGBD5,piggyBac transposable element derived 5,integral component of membrane|,None,None,10,0.4,0.104,10,2,4.06,1.7,2.99,0.179,-2.7,5.6
ENSMUSG00000032487,PTGS2,prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase),nucleus|cytoplasm|cytoplasm|endoplasmic reticulum membrane|neuron projection|protein complex|,"prostaglandin biosynthetic process|prostaglandin biosynthetic process|angiogenesis|prostaglandin metabolic process|cellular component movement|inflammatory response|response to oxidative stress|embryo implantation|learning|memory|regulation of blood pressure|negative regulation of cell proliferation|response to fructose|response to manganese ion|response to lithium ion|positive regulation vascular endothelial growth factor production|sensory perception of pain|arachidonic acid metabolic process|cyclooxygenase pathway|cyclooxygenase pathway|lipoxygenase pathway|bone mineralization|ovulation|positive regulation of prostaglandin biosynthetic process|positive regulation of fever generation|positive regulation of synaptic plasticity|negative regulation of synaptic transmission, dopaminergic|response to estradiol|response to lipopolysaccharide|response to vitamin D|response to tumor necrosis factor|cellular response to UV|maintenance of blood-brain barrier|positive regulation of NF-kappaB import into nucleus|response to drug|anagen|positive regulation of apoptotic process|small molecule metabolic process|positive regulation of nitric oxide biosynthetic process|negative regulation of cell cycle|positive regulation of vasoconstriction|negative regulation of smooth muscle contraction|positive regulation of smooth muscle contraction|decidualization|positive regulation of smooth muscle cell proliferation|regulation of inflammatory response|brown fat cell differentiation|response to glucocorticoid|negative regulation of calcium ion transport|positive regulation of synaptic transmission, glutamatergic|oxidation-reduction process|response to fatty acid|cellular response to mechanical stimulus|cellular response to ATP|cellular response to hypoxia|positive regulation of transforming growth factor beta production|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fibroblast growth factor production|positive regulation of brown fat cell differentiation|positive regulation of platelet-derived growth factor production|",peroxidase activity|prostaglandin-endoperoxide synthase activity|lipid binding|enzyme binding|heme binding|protein homodimerization activity|metal ion binding|arachidonate 15-lipoxygenase activity|,10,-1.5,0.626,10,-3.3,3.94,-2.8,2.98,0.18,-8.2,1.7
ENSMUSG00000042745,ID1,"inhibitor of DNA binding 1, dominant negative helix-loop-helix protein",nucleus|nucleoplasm|Golgi apparatus|,"negative regulation of transcription from RNA polymerase II promoter|angiogenesis|endothelial cell morphogenesis|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|heart development|negative regulation of transcription by transcription factor localization|BMP signaling pathway|protein destabilization|collagen metabolic process|negative regulation of apoptotic process|negative regulation of DNA binding|regulation of MAPK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|blood vessel endothelial cell migration|negative regulation of osteoblast differentiation|regulation of angiogenesis|negative regulation of transcription, DNA-templated|response to antibiotic|blood vessel morphogenesis|lung morphogenesis|lung vasculature development|",sequence-specific DNA binding transcription factor activity|protein binding|protein dimerization activity|,10,-4.2,4.01,10,-1.1,1.23,-3.5,2.98,0.18,-8.1,4.1
ENSMUSG00000092124,B930094E09RIK,RIKEN cDNA B930094E09 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-3.5,3.13,-3.5,2.98,0.18,-7,0.6
ENSMUSG00000048206,DNAJB8,"DnaJ (Hsp40) homolog, subfamily B, member 8",nucleus|cytosol|,chaperone-mediated protein folding|negative regulation of inclusion body assembly|,protein binding involved in protein folding|unfolded protein binding|chaperone binding|,1,3,3.13,0,0,0,3,2.98,0.18,-0.7,7
ENSMUSG00000033335,DNM2,dynamin 2,Golgi membrane|cytoplasm|Golgi apparatus|cytosol|microtubule|plasma membrane|postsynaptic density|cell junction|midbody|endocytic vesicle membrane|postsynaptic membrane|extracellular vesicular exosome|,"G2/M transition of mitotic cell cycle|GTP catabolic process|GTP catabolic process|GTP catabolic process|regulation of transcription, DNA-templated|post-Golgi vesicle-mediated transport|endocytosis|signal transduction|cell death|antigen processing and presentation of exogenous peptide antigen via MHC class II|receptor internalization|transferrin transport|positive regulation of apoptotic process|small molecule metabolic process|positive regulation of transcription, DNA-templated|nitric oxide metabolic process|synaptic vesicle transport|regulation of nitric-oxide synthase activity|membrane organization|",GTPase activity|GTPase activity|protein binding|GTP binding|microtubule binding|enzyme binding|,10,-5.2,5.92,10,-0.3,0.117,-5.1,2.98,0.18,-9.6,0.3
ENSMUSG00000024399,LTB,"lymphotoxin beta (TNF superfamily, member 3)",cellular_component|extracellular space|integral component of membrane|,immune response|signal transduction|cell-cell signaling|gene expression|skin development|positive regulation of interleukin-12 biosynthetic process|lymph node development|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|,9,-2.1,2.33,8,-1.1,1.1,-1.9,2.98,0.18,-7.1,1.3
ENSMUSG00000037974,MUC5AC,"mucin 5AC, oligomeric mucus/gel-forming",Golgi lumen|fibril|extracellular vesicular exosome|,O-glycan processing|extracellular fibril organization|post-translational protein modification|cellular protein metabolic process|,extracellular matrix structural constituent|,10,-1.9,1.41,10,-3.1,1.93,-2.3,2.97,0.181,-7,4.3
ENSMUSG00000029086,PROM1,prominin 1,photoreceptor outer segment|extracellular space|plasma membrane|integral component of plasma membrane|brush border|cell surface|apical plasma membrane|microvillus membrane|stereocilium|photoreceptor outer segment membrane|extracellular vesicular exosome|,retina layer formation|photoreceptor cell maintenance|retina morphogenesis in camera-type eye|camera-type eye photoreceptor cell differentiation|camera-type eye photoreceptor cell differentiation|glomerular visceral epithelial cell differentiation|glomerular parietal epithelial cell differentiation|positive regulation of nephron tubule epithelial cell differentiation|,protein binding|actinin binding|cadherin binding|,9,6.1,3.8,9,1.9,1.79,5.8,2.97,0.181,-5.6,13
ENSMUSG00000044122,PROCA1,protein interacting with cyclin A1,None,lipid catabolic process|,phospholipase A2 activity|calcium ion binding|,1,3.3,3.62,1,-0.4,0.0341,3.2,2.97,0.181,-0.7,7
ENSMUSG00000015957,WNT11,"wingless-type MMTV integration site family, member 11",extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|,"osteoblast differentiation|outflow tract morphogenesis|protein phosphorylation|positive regulation of gene expression|neuron differentiation|neuron differentiation|bone mineralization|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|negative regulation of cell migration|response to nutrient levels|positive regulation of Ras GTPase activity|positive regulation of transforming growth factor beta2 production|protein localization to cell surface|non-canonical Wnt signaling pathway|positive regulation of apoptotic process|negative regulation of apoptotic process|cell fate commitment|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|embryonic skeletal system development|artery morphogenesis|positive regulation of stress fiber assembly|palate development|canonical Wnt signaling pathway|cloacal septation|ventricular septum morphogenesis|lung-associated mesenchyme development|negative regulation of cell death|ureteric bud morphogenesis|negative regulation of cartilage development|neuroendocrine cell differentiation|tight junction assembly|cellular response to retinoic acid|mesonephric duct development|negative regulation of mesenchymal cell proliferation|positive regulation of protein kinase C signaling|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast growth factor production|",Ras GTPase activator activity|frizzled binding|protein kinase activator activity|transcription regulatory region DNA binding|,10,1.4,1.43,10,-1.4,2.95,-1,2.97,0.181,-9.5,2.7
ENSMUSG00000026341,ACTR3,ARP3 actin-related protein 3 homolog (yeast),Golgi membrane|podosome|cytosol|Arp2/3 protein complex|actin cytoskeleton|membrane|lamellipodium|hemidesmosome|excitatory synapse|extracellular vesicular exosome|,cellular component movement|establishment or maintenance of cell polarity|asymmetric cell division|response to carbohydrate|positive regulation of lamellipodium assembly|positive regulation of actin filament polymerization|meiotic cytokinesis|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of myosin II filament organization|innate immune response|positive regulation of neuron differentiation|response to antibiotic|positive regulation of dendrite morphogenesis|positive regulation of filopodium assembly|spindle localization|cilium morphogenesis|,actin binding|protein binding|ATP binding|,10,-0.7,0.305,10,-2.8,3.31,-2.6,2.97,0.181,-8.3,6
ENSMUSG00000073007,FAM46D,"family with sequence similarity 46, member D",None,None,None,10,-2.4,0.965,10,-1.4,2.52,-1.8,2.96,0.182,-8.2,2.3
ENSMUSG00000026374,TSN,translin,nucleus|cytoplasm|,DNA recombination|nucleic acid phosphodiester bond hydrolysis|,DNA binding|mRNA binding|endonuclease activity|protein binding|protein complex binding|sequence-specific DNA binding|,10,-2.6,3.81,10,-0.5,0.264,-1.1,2.96,0.182,-5.8,2
ENSMUSG00000031490,EIF4EBP1,eukaryotic translation initiation factor 4E binding protein 1,nucleus|cytoplasm|cytosol|protein complex|,G1/S transition of mitotic cell cycle|response to ischemia|translation|translational initiation|insulin receptor signaling pathway|gene expression|lung development|negative regulation of protein complex assembly|TOR signaling|cellular protein metabolic process|response to ethanol|positive regulation of mitotic cell cycle|negative regulation of translational initiation|,protein binding|eukaryotic initiation factor 4E binding|translation repressor activity|,9,-6,3.31,9,-1.3,2.01,-1.6,2.95,0.183,-11,1.3
ENSMUSG00000023008,FMNL3,formin-like 3,cytoplasm|,cytoskeleton organization|regulation of cell shape|cell migration|actin cytoskeleton organization|,actin binding|Rho GTPase binding|GTPase activating protein binding|,10,2.9,4.25,10,0.3,0.028,2.3,2.95,0.183,-1.2,6.7
ENSMUSG00000015305,SASH1,SAM and SH3 domain containing 1,protein complex|,protein polyubiquitination|positive regulation of endothelial cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of JUN kinase activity|positive regulation of angiogenesis|regulation of protein K63-linked ubiquitination|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of protein autoubiquitination|,protein C-terminus binding|protein kinase binding|mitogen-activated protein kinase kinase kinase binding|protein complex scaffold|,9,1.9,1.16,9,-2.9,3.34,-2,2.95,0.183,-6.8,4.4
ENSMUSG00000000058,CAV2,caveolin 2,Golgi membrane|acrosomal membrane|intracellular|nucleus|Golgi apparatus|lipid particle|cytosol|plasma membrane|integral component of plasma membrane|caveola|cell surface|membrane|transport vesicle|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|protein complex|membrane raft|perinuclear region of cytoplasm|,negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|vesicle fusion|mitochondrion organization|endoplasmic reticulum organization|regulation of mitosis|synaptic transmission|vesicle organization|negative regulation of transforming growth factor beta receptor signaling pathway|vesicle docking|skeletal muscle fiber development|protein oligomerization|positive regulation of dopamine receptor signaling pathway|caveola assembly|,protein binding|syntaxin binding|D1 dopamine receptor binding|protein homodimerization activity|phosphoprotein binding|,0,0,0,1,-3.5,3.1,-3.5,2.95,0.183,-6,0.8
ENSMUSG00000040943,TET2,tet methylcytosine dioxygenase 2,None,kidney development|5-methylcytosine catabolic process|protein O-linked glycosylation|protein O-linked glycosylation|cell cycle|post-embryonic development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|oxidation-reduction process|DNA demethylation|histone H3-K4 trimethylation|,DNA binding|protein binding|ferrous iron binding|zinc ion binding|methylcytosine dioxygenase activity|methylcytosine dioxygenase activity|methylcytosine dioxygenase activity|,2,2.1,1.45,1,-2.9,2.08,-3,2.94,0.184,-6,3.9
ENSMUSG00000027509,RAE1,ribonucleic acid export 1,nucleus|nuclear envelope|nuclear outer membrane|nuclear pore|nucleolus|cytoplasm|cytoskeleton|,mitotic cell cycle|carbohydrate metabolic process|mRNA export from nucleus|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|transmembrane transport|cellular response to organic cyclic compound|,RNA binding|microtubule binding|,8,-2.4,1.36,10,-1.7,1.87,-2.3,2.94,0.184,-6.6,5.8
ENSMUSG00000047067,DUSP28,dual specificity phosphatase 28,None,protein dephosphorylation|JNK cascade|peptidyl-tyrosine dephosphorylation|,protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|,0,0,0,1,-3.4,3.09,-3.4,2.94,0.184,-6,0.8
ENSMUSG00000030061,UBA3,ubiquitin-like modifier activating enzyme 3,nucleus|cytosol|,cellular protein modification process|proteolysis|endomitotic cell cycle|protein neddylation|protein neddylation|regulation of cell cycle|,protein binding|ATP binding|acid-amino acid ligase activity|NEDD8 activating enzyme activity|protein heterodimerization activity|,10,-4.4,3.05,10,5.8,1.54,-2.4,2.93,0.184,-9.5,7.4
ENSMUSG00000032323,CYP11A1,"cytochrome P450, family 11, subfamily A, polypeptide 1",mitochondrion|mitochondrial matrix|mitochondrial crista|perikaryon|,C21-steroid hormone biosynthetic process|C21-steroid hormone biosynthetic process|progesterone biosynthetic process|estrogen biosynthetic process|xenobiotic metabolic process|mating behavior|steroid metabolic process|cholesterol metabolic process|cholesterol metabolic process|cholesterol metabolic process|response to salt stress|response to gamma radiation|Schwann cell differentiation|sterol metabolic process|response to insecticide|biphenyl metabolic process|dibenzo-p-dioxin metabolic process|phenol-containing compound metabolic process|phthalate metabolic process|cerebellum development|hippocampus development|response to vitamin E|Leydig cell differentiation|response to L-ascorbic acid|response to genistein|vitamin D metabolic process|response to drug|response to hydrogen peroxide|response to alkaloid|small molecule metabolic process|cellular response to fibroblast growth factor stimulus|fractalkine metabolic process|response to corticosterone|oxidation-reduction process|granulosa cell differentiation|maternal process involved in female pregnancy|response to fungicide|testosterone biosynthetic process|cellular response to lipopolysaccharide|cellular response to antibiotic|cellular response to cadmium ion|cellular response to cAMP|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to follicle-stimulating hormone stimulus|cellular response to peptide hormone stimulus|cellular response to transforming growth factor beta stimulus|,iron ion binding|cholesterol monooxygenase (side-chain-cleaving) activity|cholesterol monooxygenase (side-chain-cleaving) activity|cholesterol binding|heme binding|,9,-2.1,1.63,9,-2.9,1.78,-2.4,2.93,0.184,-9.2,3
ENSMUSG00000020380,RAD50,RAD50 homolog (S. cerevisiae),"nuclear chromosome, telomeric region|nucleus|nucleoplasm|membrane|Mre11 complex|site of double-strand break|pronucleus|","regulation of mitotic recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|DNA repair|DNA repair|double-strand break repair|double-strand break repair|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|reciprocal meiotic recombination|positive regulation of protein autophosphorylation|DNA duplex unwinding|positive regulation of kinase activity|nucleic acid phosphodiester bond hydrolysis|","single-stranded DNA endodeoxyribonuclease activity|DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|zinc ion binding|3'-5' exonuclease activity|protein binding, bridging|",10,-5,5.79,10,2,1.14,-4.9,2.93,0.184,-9.5,3.2
ENSMUSG00000025083,AFAP1L2,actin filament associated protein 1-like 2,cytoplasm|,"inflammatory response|regulation of mitotic cell cycle|regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of protein tyrosine kinase activity|",SH3 domain binding|protein tyrosine kinase activator activity|SH2 domain binding|,10,-1.4,3.42,10,1.1,1.09,-1.5,2.93,0.184,-11.6,3
ENSMUSG00000024613,TCOF1,Treacher Collins-Franceschetti syndrome 1,nucleus|nucleolus|cytoplasm|,skeletal system development|transport|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|,transporter activity|protein binding|poly(A) RNA binding|,10,-3.2,4.29,10,5.3,4.49,-3.1,2.91,0.186,-8,9.7
ENSMUSG00000054717,HMGB2,high mobility group box 2,condensed chromosome|extracellular space|nucleus|nucleoplasm|cytoplasm|protein complex|perinuclear region of cytoplasm|,"positive regulation of endothelial cell proliferation|DNA topological change|base-excision repair, DNA ligation|apoptotic DNA fragmentation|chromatin organization|nucleosome assembly|regulation of transcription from RNA polymerase II promoter|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|spermatid nucleus differentiation|male gonad development|positive regulation of nuclease activity|V(D)J recombination|positive regulation of DNA binding|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|phosphatidylinositol-mediated signaling|response to steroid hormone|positive chemotaxis|DNA ligation involved in DNA repair|cell chemotaxis|cellular response to lipopolysaccharide|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|","DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|DNA binding, bending|protein domain specific binding|chemoattractant activity|transcription regulatory region DNA binding|poly(A) RNA binding|RAGE receptor binding|",4,2.8,3.85,5,-0.5,0.0337,1.9,2.91,0.186,-1.3,7
ENSMUSG00000016386,MPPED2,metallophosphoesterase domain containing 2,None,nervous system development|metabolic process|,hydrolase activity|metal ion binding|,10,-3.7,1.46,10,2.2,4.86,1.9,2.91,0.186,-5.2,5.3
ENSMUSG00000025588,NAT1,N-acetyltransferase 1 (arylamine N-acetyltransferase),cytosol|,xenobiotic metabolic process|small molecule metabolic process|,arylamine N-acetyltransferase activity|,10,-2.1,1.92,10,-2,1.19,-2,2.9,0.187,-7.9,1.3
ENSMUSG00000019782,RWDD1,RWD domain containing 1,None,None,protein binding|,1,-2.2,0.824,2,-3.5,2.46,-3.3,2.9,0.187,-7,4.9
ENSMUSG00000030200,BCL2L14,BCL2-like 14 (apoptosis facilitator),cytoplasm|cytosol|endomembrane system|membrane|intracellular organelle|,apoptotic process|regulation of apoptotic process|positive regulation of extrinsic apoptotic signaling pathway|,protein binding|protein kinase binding|,10,-1.5,0.352,10,-1.7,2.73,-1.6,2.9,0.187,-5.7,1.9
ENSMUSG00000024960,PLCB3,"phospholipase C, beta 3 (phosphatidylinositol-specific)",nucleus|cytosol|membrane|protein complex|,regulation of systemic arterial blood pressure|synaptic transmission|lipid catabolic process|intracellular signal transduction|inositol phosphate metabolic process|small molecule metabolic process|,phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|calcium ion binding|calmodulin binding|,10,-0.9,1.49,10,-2.2,2.33,-1.4,2.89,0.188,-5.5,4.2
ENSMUSG00000030124,LAG3,lymphocyte-activation gene 3,external side of plasma membrane|integral component of membrane|,cell surface receptor signaling pathway|negative regulation of interleukin-2 biosynthetic process|positive regulation of natural killer cell mediated cytotoxicity|negative regulation of T cell activation|,antigen binding|transmembrane signaling receptor activity|MHC class II protein binding|,0,0,0,1,3.2,3.03,3.2,2.88,0.189,-0.9,6
ENSMUSG00000045257,MORN2,MORN repeat containing 2,None,None,None,0,0,0,2,2.3,3.03,2.3,2.88,0.189,-1,5
ENSMUSG00000030075,CNTN3,contactin 3 (plasmacytoma associated),plasma membrane|anchored component of membrane|,cell adhesion|nervous system development|,None,10,-4.1,2.6,10,-0.7,0.702,-1.5,2.88,0.189,-7.9,4.2
ENSMUSG00000042213,ZFAND4,"zinc finger, AN1-type domain 4",None,None,zinc ion binding|,0,0,0,1,-3.4,3.02,-3.4,2.88,0.189,-6,0.9
ENSMUSG00000029433,DIABLO,"diablo, IAP-binding mitochondrial protein",mitochondrion|mitochondrial intermembrane space|cytosol|cytoplasmic side of plasma membrane|CD40 receptor complex|,apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to oxidative stress|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|positive regulation of apoptotic process|neuron apoptotic process|intrinsic apoptotic signaling pathway|,protein binding|,9,-3.3,2.39,10,-1.2,2.02,-1.3,2.88,0.189,-8.2,1
ENSMUSG00000024130,ABCA3,"ATP-binding cassette, sub-family A (ABC1), member 3",extracellular space|plasma membrane|plasma membrane|membrane|integral component of membrane|alveolar lamellar body|alveolar lamellar body membrane|,ATP catabolic process|transport|response to drug|response to glucocorticoid|transmembrane transport|,"transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of substances|",10,-2,1.98,10,-2.8,1.36,-2.5,2.87,0.19,-8.9,3.8
ENSMUSG00000034192,LSM3,"LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)",nucleus|cytosol|catalytic step 2 spliceosome|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|mRNA processing|gene expression|RNA metabolic process|mRNA metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|",protein binding|poly(A) RNA binding|,6,-3.9,4.93,7,2.9,2.85,-3.6,2.87,0.19,-7.7,5.7
ENSMUSG00000028558,CALR4,calreticulin 4,cellular_component|endoplasmic reticulum|,biological_process|,molecular_function|,1,-4.4,2.42,1,-2.4,0.998,-4.2,2.87,0.19,-9,0.3
ENSMUSG00000048377,FOXI2,forkhead box I2,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,0,0,0,1,3.2,3.01,3.2,2.86,0.19,-0.9,6
ENSMUSG00000025474,TUBGCP2,"tubulin, gamma complex associated protein 2",spindle pole|centrosome|microtubule organizing center|cytosol|cytoplasmic microtubule|membrane|,G2/M transition of mitotic cell cycle|mitotic cell cycle|protein complex assembly|microtubule nucleation|,protein binding|,10,-2.1,1.91,9,2.3,2.88,2.1,2.86,0.19,-5.2,5.8
ENSMUSG00000020081,TACR2,tachykinin receptor 2,plasma membrane|integral component of plasma membrane|,"muscle contraction|tachykinin receptor signaling pathway|excretion|positive regulation of acetylcholine secretion, neurotransmission|intestine smooth muscle contraction|negative regulation of luteinizing hormone secretion|operant conditioning|positive regulation of vascular permeability|prolactin secretion|positive regulation of uterine smooth muscle contraction|",tachykinin receptor activity|protein binding|substance K receptor activity|,10,4,0.436,10,-4.7,4.63,-3.3,2.85,0.191,-9,2.8
ENSMUSG00000055994,NOD2,nucleotide-binding oligomerization domain containing 2,cytoplasm|cytoplasm|cytosol|cytosol|cytoskeleton|plasma membrane|COP9 signalosome|cell surface|vesicle|protein complex|,"activation of MAPK activity|toll-like receptor signaling pathway|innate immune response in mucosa|microglial cell activation involved in immune response|cytokine production involved in immune response|immunoglobulin production involved in immunoglobulin mediated immune response|positive regulation of dendritic cell antigen processing and presentation|negative regulation of T cell mediated immunity|positive regulation of dendritic cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of type 2 immune response|negative regulation of inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|defense response|positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|JNK cascade|response to nutrient|detection of biotic stimulus|detection of bacterium|maintenance of gastrointestinal epithelium|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|response to lipopolysaccharide|detection of muramyl dipeptide|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of interleukin-18 production|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|activation of MAPK activity involved in innate immune response|intracellular signal transduction|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|positive regulation of phosphatidylinositol 3-kinase activity|negative regulation of growth of symbiont in host|innate immune response|innate immune response|innate immune response|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of gamma-delta T cell activation|positive regulation of epithelial cell proliferation|positive regulation of interleukin-1 beta secretion|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phagocytosis|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|positive regulation of oxidoreductase activity|stress-activated MAPK cascade|positive regulation of nitric-oxide synthase biosynthetic process|pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to peptidoglycan|cellular response to muramyl dipeptide|macrophage inflammatory protein-1 alpha production|regulation of neutrophil chemotaxis|negative regulation of macrophage apoptotic process|positive regulation of prostaglandin-E synthase activity|",protein binding|ATP binding|enzyme binding|protein kinase binding|muramyl dipeptide binding|peptidoglycan binding|CARD domain binding|,10,-1.4,1.02,10,-4.1,3.33,-3.3,2.85,0.191,-10,2.8
ENSMUSG00000031667,AKTIP,AKT interacting protein,plasma membrane|HOPS complex|FHF complex|,positive regulation of protein phosphorylation|apoptotic process|endosome organization|lysosome organization|metabolic process|endosome to lysosome transport|protein transport|positive regulation of protein binding|early endosome to late endosome transport|,protein binding|,1,2.9,2.99,0,0,0,2.9,2.85,0.191,-0.9,6
ENSMUSG00000036123,SLC9A3,"solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3",plasma membrane|plasma membrane|plasma membrane|brush border|cell surface|integral component of membrane|apical plasma membrane|brush border membrane|extracellular vesicular exosome|,ion transport|regulation of pH|sodium ion transmembrane transport|sodium ion transmembrane transport|transmembrane transport|hydrogen ion transmembrane transport|,protein binding|sodium:proton antiporter activity|PDZ domain binding|,0,0,0,1,3.2,2.99,3.2,2.85,0.191,-0.9,6
ENSMUSG00000020151,PTPRR,"protein tyrosine phosphatase, receptor type, R",extracellular space|plasma membrane|integral component of membrane|perinuclear region of cytoplasm|,in utero embryonic development|protein dephosphorylation|peptidyl-tyrosine dephosphorylation|,protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|protein kinase binding|,0,0,0,1,-3.4,2.99,-3.4,2.84,0.192,-6,0.9
ENSMUSG00000078922,TGTP1,T cell specific GTPase 1,cellular_component|,GTP catabolic process|response to interferon-gamma|response to interferon-alpha|cellular response to interferon-beta|,GTPase activity|GTP binding|,9,2,2.34,9,1.7,0.716,1.9,2.84,0.192,-5,6.5
ENSMUSG00000004637,WWOX,WW domain containing oxidoreductase,nucleus|cytoplasm|cytoplasm|mitochondrion|Golgi apparatus|cytosol|cytosol|plasma membrane|microvillus|,osteoblast differentiation|steroid metabolic process|Wnt signaling pathway|negative regulation of Wnt signaling pathway|positive regulation of transcription from RNA polymerase II promoter|skeletal system morphogenesis|oxidation-reduction process|cellular response to transforming growth factor beta stimulus|intrinsic apoptotic signaling pathway by p53 class mediator|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|,protein binding|oxidoreductase activity|oxidoreductase activity|enzyme binding|protein dimerization activity|cofactor binding|coenzyme binding|,10,-0.6,0.214,10,-2,3.05,-1.9,2.84,0.192,-8.1,1.6
ENSMUSG00000032298,NEIL1,nei endonuclease VIII-like 1 (E. coli),nucleus|chromosome|cytoplasm|microtubule organizing center|,"DNA catabolic process, endonucleolytic|base-excision repair|nucleotide-excision repair|response to oxidative stress|negative regulation of nuclease activity|","damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding|hydrolase activity, acting on glycosyl bonds|DNA N-glycosylase activity|",10,-0.7,0.445,10,-2.2,2.62,-2.2,2.84,0.192,-7.6,1.5
ENSMUSG00000003813,RAD23A,RAD23 homolog A (S. cerevisiae),proteasome complex|nucleus|cytoplasm|,nucleotide-excision repair|viral process|regulation of proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of viral genome replication|,damaged DNA binding|single-stranded DNA binding|protein binding|polyubiquitin binding|ubiquitin-specific protease binding|,10,-1.9,3.11,10,-0.8,0.534,-1.7,2.84,0.192,-4.7,1.5
ENSMUSG00000020651,SLC26A4,"solute carrier family 26 (anion exchanger), member 4",plasma membrane|integral component of membrane|apical plasma membrane|apical plasma membrane|brush border membrane|extracellular vesicular exosome|,ion transport|regulation of pH|sensory perception of sound|sulfate transport|inorganic anion transport|iodide transport|regulation of protein localization|transmembrane transport|sulfate transmembrane transport|sulfate transmembrane transport|chloride transmembrane transport|chloride transmembrane transport|,secondary active sulfate transmembrane transporter activity|chloride transmembrane transporter activity|iodide transmembrane transporter activity|sulfate transmembrane transporter activity|,10,1.1,1.45,10,-3.3,4.3,-2.7,2.84,0.192,-7.7,3.1
ENSMUSG00000058325,DOCK1,dedicator of cytokinesis 1,nucleus|cytoplasm|cytosol|membrane|,"phagocytosis, engulfment|apoptotic process|signal transduction|integrin-mediated signaling pathway|small GTPase mediated signal transduction|axon guidance|blood coagulation|cell migration|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of GTPase activity|positive regulation of GTPase activity|innate immune response|",guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|SH3 domain binding|,10,-3,2.54,9,0.8,0.99,1.3,2.84,0.192,-4.9,4.9
ENSMUSG00000054874,PCNXL3,pecanex-like 3 (Drosophila),integral component of membrane|,None,None,1,-2.5,0.996,1,-2.9,2.08,-2.8,2.84,0.192,-5,1
ENSMUSG00000028415,SPINK4,"serine peptidase inhibitor, Kazal type 4",extracellular region|,negative regulation of endopeptidase activity|response to drug|,serine-type endopeptidase inhibitor activity|,0,0,0,1,-3.4,2.99,-3.4,2.84,0.192,-6,0.9
ENSMUSG00000003131,PAFAH1B2,"platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)",nucleolus|cytoplasm|cytoplasm|cytosol|plasma membrane|extracellular vesicular exosome|,lipid metabolic process|spermatogenesis|brain development|lipid catabolic process|positive regulation of macroautophagy|,1-alkyl-2-acetylglycerophosphocholine esterase activity|protein homodimerization activity|protein heterodimerization activity|,10,-0.8,0.272,10,-2.8,2.8,-2.9,2.83,0.193,-8.4,1.7
ENSMUSG00000031935,MED17,mediator complex subunit 17,nucleus|nucleoplasm|transcription factor complex|membrane|mediator complex|,"regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|gene expression|stem cell maintenance|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II transcription cofactor activity|transcription cofactor activity|transcription coactivator activity|receptor activity|ligand-dependent nuclear receptor transcription coactivator activity|vitamin D receptor binding|thyroid hormone receptor binding|,0,0,0,1,-3.4,2.97,-3.4,2.83,0.193,-6,0.9
ENSMUSG00000053553,3110082I17RIK,RIKEN cDNA 3110082I17 gene,cellular_component|,biological_process|,poly(A) RNA binding|,10,-3.9,1.77,10,2.4,2.23,-2.1,2.83,0.193,-7,4.6
ENSMUSG00000035781,R3HDM4,R3H domain containing 4,nucleus|,None,nucleic acid binding|,9,0,0,10,3.1,5.27,2.9,2.83,0.193,-0.7,7.1
ENSMUSG00000090491,FRYL,FRY-like,None,"transcription, DNA-templated|regulation of transcription, DNA-templated|",None,1,-2.6,1.04,1,-2.9,2,-2.8,2.83,0.193,-5,1
ENSMUSG00000040407,AKAP9,A kinase (PRKA) anchor protein 9,pericentriolar material|Golgi apparatus|centrosome|cytosol|cytoskeleton|voltage-gated potassium channel complex|intracellular membrane-bounded organelle|,G2/M transition of mitotic cell cycle|mitotic cell cycle|transport|signal transduction|synaptic transmission|,receptor binding|protein binding|protein complex scaffold|ion channel binding|,1,2.9,2.97,0,0,0,2.9,2.82,0.194,-0.9,6
ENSMUSG00000039269,2300002M23RIK,RIKEN cDNA 2300002M23 gene,extracellular region|proteinaceous extracellular matrix|interstitial matrix|extracellular matrix|,extracellular matrix organization|,fibronectin binding|collagen binding|glycosaminoglycan binding|hyaluronic acid binding|heparin binding|laminin binding|collagen V binding|,10,-0.7,1.37,10,-0.9,1.76,-0.8,2.82,0.194,-9,1
ENSMUSG00000029234,TMEM165,transmembrane protein 165,Golgi membrane|lysosomal membrane|Golgi apparatus|endosome membrane|integral component of membrane|early endosome membrane|late endosome membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|,protein N-linked glycosylation|cellular calcium ion homeostasis|Golgi calcium ion transport|regulation of lysosomal lumen pH|,None,9,-3.2,3.54,9,-1,1.08,-1.6,2.82,0.194,-6.7,0.7
ENSMUSG00000024696,LPXN,leupaxin,podosome|nucleus|cytoplasm|plasma membrane|focal adhesion|membrane|cell projection|perinuclear region of cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|cell adhesion|negative regulation of cell adhesion|signal transduction|regulation of cell adhesion mediated by integrin|negative regulation of B cell receptor signaling pathway|",transcription cofactor activity|protein binding|zinc ion binding|,1,2.9,2.97,0,0,0,2.9,2.82,0.194,-0.9,6
ENSMUSG00000004846,PLOD3,"procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3",endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum membrane|extracellular vesicular exosome|,in utero embryonic development|endothelial cell morphogenesis|cellular protein modification process|protein localization|neural tube development|extracellular matrix organization|collagen fibril organization|cellular response to hormone stimulus|vasodilation|epidermis morphogenesis|oxidation-reduction process|lung morphogenesis|basement membrane assembly|,iron ion binding|protein binding|procollagen-lysine 5-dioxygenase activity|L-ascorbic acid binding|procollagen glucosyltransferase activity|procollagen galactosyltransferase activity|,0,0,0,1,3.2,2.95,3.2,2.81,0.195,-0.9,6
ENSMUSG00000079484,PHYHD1,phytanoyl-CoA dioxygenase domain containing 1,None,oxidation-reduction process|,metal ion binding|dioxygenase activity|,0,0,0,1,-3.3,2.96,-3.3,2.81,0.195,-6,0.9
ENSMUSG00000067242,LGI1,"leucine-rich, glioma inactivated 1",extracellular region|extracellular space|cell junction|synapse|,nervous system development|axon guidance|cell proliferation|positive regulation of cell growth|neuron projection development|positive regulation of synaptic transmission|protein homooligomerization|,receptor binding|protein binding|,10,2,2.04,10,1.3,1.18,1.8,2.8,0.196,-2.1,5.9
ENSMUSG00000063820,ARL9,ADP-ribosylation factor-like 9,intracellular|,small GTPase mediated signal transduction|,GTP binding|,9,1.5,3.62,10,-0.6,0.651,1.5,2.79,0.197,-3.7,4.9
ENSMUSG00000066752,GM10176,predicted gene 10176,cellular_component|,biological_process|,molecular_function|,2,-2.4,0.562,2,-3.1,2.52,-2.8,2.79,0.197,-6,1.5
ENSMUSG00000031878,NAE1,NEDD8 activating enzyme E1 subunit 1,nucleus|cytoplasm|cytosol|plasma membrane|,signal transduction|mitotic DNA replication checkpoint|regulation of apoptotic process|regulation of neuron apoptotic process|protein neddylation|protein neddylation|neuron apoptotic process|,protein binding|NEDD8 activating enzyme activity|ubiquitin protein ligase binding|protein heterodimerization activity|,5,2.2,0.713,7,-1.9,2.6,-1.7,2.79,0.197,-6,3.1
ENSMUSG00000034488,EDIL3,EGF-like repeats and discoidin I-like domains 3,extracellular vesicular exosome|,cell adhesion|multicellular organismal development|positive regulation of cell-substrate adhesion|,integrin binding|calcium ion binding|,0,0,0,1,3.1,2.92,3.1,2.77,0.199,-0.9,6
ENSMUSG00000028640,TFAP2C,transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma),nucleus|,negative regulation of transcription from RNA polymerase II promoter|trophectodermal cell differentiation|hair follicle development|keratinocyte development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell-cell signaling|male gonad development|forebrain neuron fate commitment|cerebral cortex development|germ-line stem cell maintenance|somatic stem cell maintenance|regulation of epidermis development|positive regulation of transcription from RNA polymerase II promoter|sebaceous gland development|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis|epithelial cell proliferation involved in mammary gland duct elongation|,RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|protein dimerization activity|,10,-1.7,3.72,10,1.3,0.688,-1.6,2.76,0.2,-6.9,2.6
ENSMUSG00000001767,CRNKL1,crooked neck pre-mRNA splicing factor 1,spliceosomal complex|cytoplasm|nuclear speck|catalytic step 2 spliceosome|,"spliceosomal complex assembly|mRNA splicing, via spliceosome|",RNA binding|protein binding|poly(A) RNA binding|,8,-3.1,2.43,7,4.1,3.61,2.2,2.76,0.2,-6.3,7.3
ENSMUSG00000055116,ARNTL,aryl hydrocarbon receptor nuclear translocator-like,nucleus|transcription factor complex|PML body|chromatoid body|,"protein import into nucleus, translocation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|signal transduction|spermatogenesis|circadian rhythm|negative regulation of TOR signaling|circadian regulation of gene expression|circadian regulation of gene expression|regulation of protein catabolic process|regulation of hair cycle|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of neurogenesis|regulation of insulin secretion|regulation of cell cycle|response to redox state|positive regulation of canonical Wnt signaling pathway|oxidative stress-induced premature senescence|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway|regulation of cellular senescence|positive regulation of skeletal muscle cell differentiation|",transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|DNA binding|DNA binding|signal transducer activity|protein binding|aryl hydrocarbon receptor binding|bHLH transcription factor binding|sequence-specific DNA binding|protein heterodimerization activity|Hsp90 protein binding|E-box binding|,2,-3.4,2.9,0,0,0,-3.4,2.76,0.2,-7,0.7
ENSMUSG00000003379,CD79A,"CD79a molecule, immunoglobulin-associated alpha",multivesicular body|plasma membrane|external side of plasma membrane|integral component of membrane|B cell receptor complex|membrane raft|,B cell differentiation|B cell proliferation|B cell activation|B cell receptor signaling pathway|,transmembrane signaling receptor activity|,9,-0.6,0.212,10,-1.5,2.83,-1.4,2.75,0.201,-5.7,0.6
ENSMUSG00000052221,PPP1R36,"protein phosphatase 1, regulatory subunit 36",None,negative regulation of phosphatase activity|,protein phosphatase inhibitor activity|phosphatase binding|,10,-1,0.532,10,-1.7,2.68,-1.4,2.75,0.201,-8.1,4.5
ENSMUSG00000056987,FAM71D,"family with sequence similarity 71, member D",nucleus|cytoplasm|,None,None,9,0.8,0.843,10,-2.1,3.56,-2.1,2.75,0.201,-6.2,2.3
ENSMUSG00000084063,GM5934,predicted gene 5934,cellular_component|,biological_process|,molecular_function|,3,-4.9,4.43,4,3.9,3.66,-4.7,2.74,0.202,-10,6.4
ENSMUSG00000004885,CRABP2,cellular retinoic acid binding protein 2,nucleus|cytoplasm|endoplasmic reticulum|extracellular vesicular exosome|,"regulation of transcription, DNA-templated|transport|signal transduction|epidermis development|embryonic forelimb morphogenesis|retinoic acid metabolic process|",retinoic acid binding|transporter activity|retinoid binding|retinal binding|retinol binding|,0,0,0,1,-3.3,2.88,-3.3,2.74,0.202,-6,0.9
ENSMUSG00000036501,FAM13B,"family with sequence similarity 13, member B",cytosol|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,0,0,0,1,-3.3,2.88,-3.3,2.74,0.202,-6,0.9
ENSMUSG00000035228,CCDC106,coiled-coil domain containing 106,nucleus|nucleolus|cytoplasm|,None,protein binding|,2,3.1,2.88,0,0,0,3.1,2.74,0.202,-3.8,7
ENSMUSG00000029389,DDX55,DEAD (Asp-Glu-Ala-Asp) box polypeptide 55,membrane|,ATP catabolic process|,ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,0,0,0,1,-3.3,2.88,-3.3,2.74,0.202,-6,0.9
ENSMUSG00000018821,AVPI1,arginine vasopressin-induced 1,None,activation of MAPK activity|cell cycle|,None,10,-1.1,0.869,10,-1.6,2.18,-1.4,2.74,0.202,-5.3,3.5
ENSMUSG00000039159,UBE2H,ubiquitin-conjugating enzyme E2H,None,ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|,9,1.8,1.74,9,-2.3,2.75,-2.3,2.74,0.202,-6.6,4.1
ENSMUSG00000028572,HOOK1,hook microtubule-tethering protein 1,microtubule|HOPS complex|FHF complex|,endosome organization|lysosome organization|multicellular organismal development|spermatid development|endosome to lysosome transport|protein transport|early endosome to late endosome transport|,actin binding|protein binding|identical protein binding|,10,0,0,10,-1.8,2.98,-1.6,2.73,0.202,-5.8,2.2
ENSMUSG00000019848,POPDC3,popeye domain containing 3,integral component of membrane|,biological_process|,molecular_function|,9,-1,0.559,10,-1.4,2.45,-1.2,2.73,0.202,-4.3,2.4
ENSMUSG00000028098,RNF115,ring finger protein 115,cytosol|,protein autoubiquitination|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,0,0,0,1,3.1,2.88,3.1,2.73,0.202,-0.9,6
ENSMUSG00000057614,GNAI1,"guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1",nucleus|cytoplasm|lysosomal membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|plasma membrane|midbody|extracellular vesicular exosome|,GTP catabolic process|cell cycle|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|synaptic transmission|blood coagulation|platelet activation|response to peptide hormone|cell division|,GTPase activity|GTPase activity|GTPase activity|signal transducer activity|protein binding|GTP binding|G-protein beta/gamma-subunit complex binding|G-protein coupled serotonin receptor binding|metal ion binding|,10,-2.4,2.29,10,2.5,1.76,-2.3,2.73,0.202,-5.2,5.1
ENSMUSG00000001909,TRMT1,tRNA methyltransferase 1 homolog (S. cerevisiae),None,tRNA methylation|,tRNA binding|tRNA (guanine-N2-)-methyltransferase activity|poly(A) RNA binding|metal ion binding|,0,0,0,1,3.1,2.88,3.1,2.73,0.202,-0.9,6
ENSMUSG00000048583,IGF2,insulin-like growth factor 2 (somatomedin A),extracellular region|extracellular space|plasma membrane|platelet alpha granule lumen|extracellular vesicular exosome|,"skeletal system development|osteoblast differentiation|positive regulation of protein phosphorylation|platelet degranulation|glucose metabolic process|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-templated|multicellular organismal development|female pregnancy|blood coagulation|memory|positive regulation of cell proliferation|insulin receptor signaling pathway|response to radiation|organ morphogenesis|platelet activation|exocrine pancreas development|response to nutrient levels|response to estradiol|response to nicotine|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|positive regulation of activated T cell proliferation|response to drug|positive regulation of catalytic activity|positive regulation of MAPK cascade|cellular protein metabolic process|response to ethanol|positive regulation of glycogen biosynthetic process|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of insulin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|striated muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|cellular response to mechanical stimulus|positive regulation of protein serine/threonine kinase activity|positive regulation of steroid hormone biosynthetic process|positive regulation of receptor activity|positive regulation of glycogen (starch) synthase activity|",insulin receptor binding|insulin-like growth factor receptor binding|hormone activity|protein binding|growth factor activity|receptor activator activity|protein serine/threonine kinase activator activity|,10,6.7,6.11,10,-5.3,1.47,6.6,2.72,0.203,-5.4,15
ENSMUSG00000029169,DHX15,DEAH (Asp-Glu-Ala-His) box helicase 15,nucleus|U12-type spliceosomal complex|nucleolus|U2-type post-mRNA release spliceosomal complex|,ATP catabolic process|mRNA processing|RNA splicing|,RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,0,0,0,1,-3.3,2.86,-3.3,2.72,0.203,-6,0.9
ENSMUSG00000040998,NPNT,nephronectin,extracellular region|proteinaceous extracellular matrix|basement membrane|smooth muscle contractile fiber|integrin alpha8-beta1 complex|extracellular vesicular exosome|,ureteric bud development|branching involved in ureteric bud morphogenesis|cell-matrix adhesion|positive regulation of alkaline phosphatase activity|positive regulation of cell-substrate adhesion|extracellular matrix organization|positive regulation of transforming growth factor beta receptor signaling pathway|cell-cell adhesion mediated by integrin|establishment of protein localization|positive regulation of osteoblast differentiation|positive regulation of smooth muscle contraction|positive regulation of ERK1 and ERK2 cascade|cellular response to tumor necrosis factor|pilomotor reflex|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|,integrin binding|integrin binding|calcium ion binding|,10,-5.3,1.61,10,-1.9,2.31,-2.9,2.72,0.203,-9.6,1.6
ENSMUSG00000070934,RRAGA,Ras-related GTP binding A,nucleus|cytoplasm|lysosome|lysosomal membrane|Golgi apparatus|intracellular membrane-bounded organelle|,apoptotic process|cell death|modulation by virus of host morphology or physiology|positive regulation of TOR signaling|cellular protein localization|positive regulation of cytolysis|cellular response to amino acid stimulus|,protein binding|GTP binding|protein homodimerization activity|protein heterodimerization activity|phosphoprotein binding|,1,-5.5,2.63,1,-2.2,0.786,-5.3,2.72,0.203,-11,0.2
ENSMUSG00000053477,TCF4,transcription factor 4,nucleus|transcription factor complex|,"DNA-templated transcription, initiation|transcription initiation from RNA polymerase II promoter|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein-DNA complex assembly|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|protein C-terminus binding|protein heterodimerization activity|protein heterodimerization activity|E-box binding|,10,-0.8,0.526,10,-1.3,2.45,-1.1,2.71,0.204,-5.4,0.8
ENSMUSG00000021918,NEK4,NIMA-related kinase 4,nucleus|,protein phosphorylation|mitotic nuclear division|signal transduction by phosphorylation|,protein serine/threonine kinase activity|ATP binding|metal ion binding|,10,-3.1,2.69,10,-2,0.476,-2.9,2.71,0.204,-10,3.6
ENSMUSG00000035305,ROR1,receptor tyrosine kinase-like orphan receptor 1,cytoplasm|plasma membrane|integral component of plasma membrane|receptor complex|,transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|,transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|Wnt-protein binding|,1,-4.3,2.39,1,-2.3,0.856,-4.1,2.71,0.204,-9,0.4
ENSMUSG00000033712,CCAR2,cell cycle and apoptosis regulator 2,nuclear chromatin|nucleus|spliceosomal complex|cytoplasm|mitochondrial matrix|DBIRD complex|,"mRNA processing|cellular response to DNA damage stimulus|cell cycle|RNA splicing|response to UV|regulation of DNA-templated transcription, elongation|positive regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of catalytic activity|negative regulation of catalytic activity|mitochondrial fragmentation involved in apoptotic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA damage checkpoint|",RNA polymerase II core binding|enzyme inhibitor activity|enzyme inhibitor activity|protein binding|enzyme binding|poly(A) RNA binding|,10,-3.6,4.88,10,2.6,1.14,-3,2.71,0.204,-7.5,3.2
ENSMUSG00000022391,RANGAP1,Ran GTPase activating protein 1,kinetochore|condensed chromosome kinetochore|spindle pole|nuclear pore|cytoplasm|cytosol|nuclear membrane|perinuclear region of cytoplasm|,mitotic cell cycle|signal transduction|positive regulation of Ran GTPase activity|positive regulation of Ran GTPase activity|negative regulation of protein export from nucleus|,Ran GTPase activator activity|protein binding|,4,-2.1,2.21,2,2.5,1.3,-2.1,2.71,0.204,-5,3.7
ENSMUSG00000019822,SMPD2,"sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)",plasma membrane|integral component of plasma membrane|caveola|,sphingolipid metabolic process|sphingomyelin metabolic process|glycosphingolipid metabolic process|response to mechanical stimulus|small molecule metabolic process|ceramide biosynthetic process|neurotrophin TRK receptor signaling pathway|apoptotic signaling pathway|,sphingomyelin phosphodiesterase activity|metal ion binding|,0,0,0,1,3.1,2.84,3.1,2.7,0.205,-1,6
ENSMUSG00000005054,CSTB,cystatin B (stefin B),extracellular space|nucleolus|cytoplasm|extracellular vesicular exosome|,adult locomotory behavior|negative regulation of peptidase activity|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|regulation of apoptotic process|negative regulation of proteolysis|,protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|poly(A) RNA binding|,9,-1.7,1.75,9,-1.2,1.26,-1.4,2.7,0.205,-4.7,1.3
ENSMUSG00000036815,DPP10,dipeptidyl-peptidase 10 (non-functional),membrane|integral component of membrane|,proteolysis|,serine-type peptidase activity|,9,-6.5,1.8,9,-1.1,1.63,-1.1,2.7,0.205,-11.4,1.5
ENSMUSG00000026029,CASP8,"caspase 8, apoptosis-related cysteine peptidase",nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|microtubule organizing center|cytosol|cytosol|cytoskeleton|Noc1p-Noc2p complex|death-inducing signaling complex|CD95 death-inducing signaling complex|neuron projection|cell body|membrane raft|ripoptosome|,"angiogenesis|neural tube formation|toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|proteolysis|apoptotic process|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular component disassembly involved in execution phase of apoptosis|heart development|extrinsic apoptotic signaling pathway via death domain receptors|response to cold|viral process|natural killer cell activation|macrophage differentiation|response to cobalt ion|response to estradiol|response to lipopolysaccharide|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|TRAIL-activated apoptotic signaling pathway|T cell activation|B cell activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|response to ethanol|positive regulation of macrophage differentiation|positive regulation of proteolysis|response to antibiotic|protein heterooligomerization|proteolysis involved in cellular protein catabolic process|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|regulation of thymocyte apoptotic process|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to mechanical stimulus|cellular response to organic cyclic compound|apoptotic signaling pathway|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway|execution phase of apoptosis|activation of cysteine-type endopeptidase activity|hepatocyte apoptotic process|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|",cysteine-type endopeptidase activity|cysteine-type endopeptidase activity|tumor necrosis factor receptor binding|protein binding|peptidase activity|cysteine-type peptidase activity|ubiquitin protein ligase binding|death effector domain binding|scaffold protein binding|cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|,10,-1.9,1.15,10,-3.1,2.1,-2.4,2.69,0.206,-7.1,0.8
ENSMUSG00000045281,GPR20,G protein-coupled receptor 20,integral component of plasma membrane|receptor complex|,G-protein coupled receptor signaling pathway|,G-protein coupled receptor activity|,1,2.8,2.83,0,0,0,2.8,2.69,0.206,-1,6
ENSMUSG00000029910,MAD2L1,MAD2 mitotic arrest deficient-like 1 (yeast),kinetochore|kinetochore|condensed chromosome kinetochore|spindle pole|nucleus|nuclear pore|cytosol|cytosol|perinuclear region of cytoplasm|mitotic spindle|,mitotic sister chromatid segregation|mitotic cell cycle|mitotic cell cycle checkpoint|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein catabolic process|negative regulation of apoptotic process|negative regulation of mitotic cell cycle|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|,protein binding|identical protein binding|protein homodimerization activity|,9,-5.3,4.25,9,-1.3,1.26,-5.1,2.69,0.206,-10.3,1.5
ENSMUSG00000050074,SPINK8,"serine peptidase inhibitor, Kazal type 8 (putative)",extracellular region|,negative regulation of endopeptidase activity|,serine-type endopeptidase inhibitor activity|,10,-3.1,2.65,10,-1.8,0.731,-2.8,2.69,0.206,-7.8,4
ENSMUSG00000007659,BCL2L1,BCL2-like 1,nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|centrosome|cytosol|integral component of membrane|cell junction|synaptic vesicle membrane|nuclear membrane|Bcl-2 family protein complex|,"cytokinesis|ovarian follicle development|in utero embryonic development|release of cytochrome c from mitochondria|endocytosis|apoptotic process|mitotic cell cycle checkpoint|germ cell development|spermatogenesis|cell proliferation|positive regulation of cell proliferation|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|apoptotic mitochondrial changes|fertilization|negative regulation of autophagy|suppression by virus of host apoptotic process|response to cytokine|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|growth|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|innate immune response|response to cycloheximide|regulation of mitochondrial membrane permeability|neuron apoptotic process|regulation of mitochondrial membrane potential|cellular process regulating host cell cycle in response to virus|cellular response to amino acid stimulus|cellular response to alkaloid|cellular response to gamma radiation|apoptotic process in bone marrow|negative regulation of establishment of protein localization to plasma membrane|negative regulation of release of cytochrome c from mitochondria|negative regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|hepatocyte apoptotic process|negative regulation of execution phase of apoptosis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|",protein binding|protein kinase binding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|BH3 domain binding|,10,-3.4,3.32,10,-0.9,0.862,-1.5,2.68,0.207,-6.4,0.6
ENSMUSG00000022240,CTNND2,"catenin (cadherin-associated protein), delta 2",nucleus|cytoplasm|adherens junction|postsynaptic density|neuron projection|perikaryon|,"morphogenesis of a branching structure|transcription, DNA-templated|regulation of transcription, DNA-templated|cell adhesion|signal transduction|multicellular organismal development|learning|single organismal cell-cell adhesion|regulation of synaptic plasticity|",protein binding|,9,2.2,2.29,9,-2.2,2.77,-1.5,2.68,0.207,-7.3,4.8
ENSMUSG00000028211,TRP53INP1,transformation related protein 53 inducible nuclear protein 1,nucleus|nucleus|cytoplasm|autophagic vacuole|cytosol|cytoplasmic vesicle|,"transcription, DNA-templated|regulation of transcription, DNA-templated|autophagy|apoptotic process|cell cycle arrest|negative regulation of cell proliferation|response to heat|positive regulation of autophagy|negative regulation of cell migration|cellular response to UV|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|autophagic cell death|cellular response to ethanol|cellular response to hydroperoxide|cellular response to methyl methanesulfonate|positive regulation of apoptotic signaling pathway|",antioxidant activity|,10,3.2,4.26,10,-1.6,1.61,-1.7,2.68,0.207,-7.6,7.1
ENSMUSG00000006724,CYP27B1,"cytochrome P450, family 27, subfamily B, polypeptide 1",cytoplasm|mitochondrion|mitochondrion|mitochondrial outer membrane|,vitamin metabolic process|xenobiotic metabolic process|calcium ion transport|steroid metabolic process|negative regulation of cell proliferation|negative regulation of calcidiol 1-monooxygenase activity|positive regulation of vitamin D 24-hydroxylase activity|bone mineralization|negative regulation of cell growth|regulation of bone mineralization|response to lipopolysaccharide|response to vitamin D|response to interferon-gamma|calcitriol biosynthetic process from calciol|vitamin D metabolic process|vitamin D metabolic process|vitamin D catabolic process|response to estrogen|small molecule metabolic process|positive regulation of keratinocyte differentiation|decidualization|calcium ion homeostasis|oxidation-reduction process|G1 to G0 transition|positive regulation of vitamin D receptor signaling pathway|,calcidiol 1-monooxygenase activity|iron ion binding|heme binding|,10,-2.1,1.15,9,-1.6,1.87,-1.8,2.68,0.207,-9.2,2.3
ENSMUSG00000074677,SIRPB1C,N/A,None,None,None,1,-3.9,2.2,1,-2.3,0.949,-3.7,2.68,0.207,-8,0.6
ENSMUSG00000021958,PINX1,"PIN2/TERF1 interacting, telomerase inhibitor 1","nuclear chromosome|kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|nucleolus|spindle|",telomere maintenance via telomerase|mitotic metaphase plate congression|negative regulation of cell proliferation|regulation of telomerase activity|negative regulation of telomerase activity|,protein binding|telomerase inhibitor activity|telomeric RNA binding|,10,-3.9,5.67,10,0,0,-3.9,2.68,0.207,-7.5,0.5
ENSMUSG00000040219,TTC12,tetratricopeptide repeat domain 12,None,None,None,1,-3.9,2.17,1,-2.3,0.949,-3.7,2.67,0.208,-8,0.6
ENSMUSG00000001707,EEF1E1,eukaryotic translation elongation factor 1 epsilon 1,nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,"tRNA aminoacylation for protein translation|negative regulation of cell proliferation|gene expression|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|",protein binding|,7,-1.6,0.531,9,1.6,2.81,1.6,2.67,0.208,-5.3,4.7
ENSMUSG00000029547,INTS1,integrator complex subunit 1,membrane|integral component of membrane|nuclear membrane|integrator complex|,inner cell mass cell proliferation|snRNA processing|U2 snRNA 3'-end processing|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|,None,9,-1,0.968,9,-2.7,2.59,2.8,2.67,0.208,-5.7,7
ENSMUSG00000054932,AFP,alpha-fetoprotein,extracellular space|cytoplasm|,ovulation from ovarian follicle|transport|progesterone metabolic process|SMAD protein signal transduction|,metal ion binding|,9,-2.3,0.535,9,-1.4,2.8,-2.1,2.67,0.208,-5.7,2.9
ENSMUSG00000054863,FAM19A5,"family with sequence similarity 19 (chemokine (C-C motif)-like), member A5",extracellular region|integral component of membrane|,None,None,10,-3.4,4.87,10,0.7,0.367,-3.2,2.67,0.208,-8.6,1.5
ENSMUSG00000030852,TACC2,"transforming, acidic coiled-coil containing protein 2",nucleus|nucleolus|cytoplasm|Golgi apparatus|microtubule organizing center|,cerebral cortex development|neurogenesis|interkinetic nuclear migration|astral microtubule organization|regulation of microtubule-based process|,protein domain specific binding|nuclear hormone receptor binding|,10,-4.7,1.46,10,-3.6,1.66,-4.6,2.66,0.209,-8.8,2.5
ENSMUSG00000031465,ANGPT2,angiopoietin 2,extracellular region|extracellular space|nucleus|plasma membrane|cell projection|,angiogenesis|response to hypoxia|signal transduction|germ cell development|blood coagulation|response to radiation|response to mechanical stimulus|response to glucose|negative regulation of cell-substrate adhesion|response to organic cyclic compound|response to activity|negative regulation of angiogenesis|organ regeneration|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|Tie signaling pathway|leukocyte migration|negative regulation of positive chemotaxis|maternal process involved in female pregnancy|cellular response to growth factor stimulus|glomerulus vasculature development|,receptor binding|protein binding|receptor tyrosine kinase binding|metal ion binding|,10,-1.9,0.00488,10,-2.3,2.84,-2.2,2.66,0.209,-7.5,2.1
ENSMUSG00000024215,SPDEF,SAM pointed domain containing ETS transcription factor,nucleus|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|multicellular organismal development|negative regulation of cell fate commitment|positive regulation of cell fate commitment|cell differentiation|positive regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|lung goblet cell differentiation|intestinal epithelial cell development|,sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|,1,-6.5,3.38,1,-0.6,0.0759,-6.4,2.66,0.209,-13,0.1
ENSMUSG00000004789,DLST,dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex),nucleus|mitochondrial matrix|membrane|oxoglutarate dehydrogenase complex|extracellular vesicular exosome|,generation of precursor metabolites and energy|tricarboxylic acid cycle|lysine catabolic process|L-lysine catabolic process to acetyl-CoA via saccharopine|cellular nitrogen compound metabolic process|cellular metabolic process|small molecule metabolic process|,dihydrolipoyllysine-residue succinyltransferase activity|,10,-4,3.48,10,-0.7,0.618,-1.9,2.66,0.209,-7.3,1
ENSMUSG00000041498,KIF14,kinesin family member 14,nucleus|cytoplasm|spindle|kinesin complex|microtubule|membrane|,microtubule-based movement|metabolic process|regulation of cell adhesion|regulation of cell migration|regulation of Rap protein signal transduction|negative regulation of integrin activation|substrate adhesion-dependent cell spreading|establishment of protein localization|,microtubule motor activity|protein binding|ATP binding|microtubule binding|PDZ domain binding|,10,-1,0.831,10,-1.5,2.17,-1.2,2.65,0.21,-5.4,2.5
ENSMUSG00000026484,RNF2,ring finger protein 2,ubiquitin ligase complex|sex chromatin|nucleus|nucleoplasm|nuclear body|PcG protein complex|PRC1 complex|MLL1 complex|,"negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|gastrulation with mouth forming second|transcription, DNA-templated|anterior/posterior axis specification|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|",chromatin binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|RING-like zinc finger domain binding|,9,3.6,2.79,9,-1.2,1.16,-1,2.65,0.21,-4.3,7.2
ENSMUSG00000058729,LIN9,lin-9 DREAM MuvB core complex component,nucleoplasm|transcriptional repressor complex|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|DNA replication|transcription, DNA-templated|regulation of cell cycle|",protein binding|,10,-3,1.44,10,1.9,3.69,1.6,2.65,0.21,-7.3,4.6
ENSMUSG00000021367,EDN1,endothelin 1,extracellular region|extracellular space|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|prostaglandin biosynthetic process|patterning of blood vessels|response to hypoxia|in utero embryonic development|histamine secretion|regulation of systemic arterial blood pressure by endothelin|regulation of pH|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G-protein coupled receptor signaling pathway|cell-cell signaling|heart development|respiratory gaseous exchange|body fluid secretion|positive regulation of cell proliferation|dorsal/ventral pattern formation|multicellular organismal aging|positive regulation of heart rate|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|positive regulation of receptor biosynthetic process|neural crest cell development|phosphatidylinositol 3-kinase signaling|artery smooth muscle contraction|artery smooth muscle contraction|vein smooth muscle contraction|glucose transport|cell growth|regulation of vasoconstriction|sensory perception of pain|calcium-mediated signaling|peptide hormone secretion|nitric oxide transport|negative regulation of blood coagulation|positive regulation of cell migration|negative regulation of cAMP biosynthetic process|phospholipase D-activating G-protein coupled receptor signaling pathway|negative regulation of cellular protein metabolic process|response to lipopolysaccharide|response to testosterone|negative regulation of smooth muscle cell apoptotic process|response to nicotine|positive regulation of urine volume|positive regulation of renal sodium excretion|epithelial fluid transport|vasoconstriction|protein kinase C deactivation|middle ear morphogenesis|positive regulation of odontogenesis|response to drug|superoxide anion generation|rhythmic excitation|response to amino acid|positive regulation of MAP kinase activity|positive regulation of JUN kinase activity|leukocyte activation|positive regulation of nitric oxide biosynthetic process|positive regulation of cell size|positive regulation of mitosis|positive regulation of smooth muscle contraction|positive regulation of hormone secretion|negative regulation of hormone secretion|inositol phosphate-mediated signaling|positive regulation of smooth muscle cell proliferation|cartilage development|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|negative regulation of nitric-oxide synthase biosynthetic process|membrane depolarization|regulation of sensory perception of pain|maternal process involved in parturition|positive regulation of sarcomere organization|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of chemokine-mediated signaling pathway|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of neutrophil chemotaxis|,cytokine activity|hormone activity|protein binding|endothelin A receptor binding|endothelin B receptor binding|,10,0,0,10,-5.6,3.95,-1,2.65,0.21,-10.9,0.7
ENSMUSG00000023277,TWF2,twinfilin actin-binding protein 2,cytoplasm|cytoskeleton|myofibril|lamellipodium|filopodium|growth cone|stereocilium|perinuclear region of cytoplasm|extracellular vesicular exosome|,positive regulation of lamellipodium assembly|positive regulation of neuron projection development|cell projection organization|negative regulation of actin filament polymerization|regulation of microvillus length|regulation of actin cytoskeleton organization|sequestering of actin monomers|positive regulation of axon extension|barbed-end actin filament capping|cellular response to retinoic acid|cellular response to growth factor stimulus|,"actin monomer binding|protein kinase C binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|poly(A) RNA binding|",10,-1.7,2.47,10,-2.1,0.444,-1.9,2.64,0.211,-7.5,4.1
ENSMUSG00000074129,RPL13A,ribosomal protein L13a,nucleus|cytosol|large ribosomal subunit|membrane|cytosolic large ribosomal subunit|ribonucleoprotein complex|GAIT complex|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|gene expression|viral process|RNA metabolic process|mRNA metabolic process|negative regulation of translation|negative regulation of translation|viral life cycle|viral transcription|cellular protein metabolic process|cellular response to interferon-gamma|negative regulation of formation of translation preinitiation complex|",structural constituent of ribosome|poly(A) RNA binding|,9,-2.8,1.92,10,-3.2,0.978,-3,2.64,0.211,-9,4.5
ENSMUSG00000028859,CSF3R,colony stimulating factor 3 receptor (granulocyte),extracellular region|integral component of plasma membrane|,defense response|cell adhesion|signal transduction|cytokine-mediated signaling pathway|neutrophil chemotaxis|odontogenesis of dentin-containing tooth|,receptor activity|cytokine receptor activity|protein binding|,9,-3,3.27,10,-0.7,0.659,-1.7,2.64,0.211,-9.7,2
ENSMUSG00000060260,PWWP2B,PWWP domain containing 2B,None,None,None,9,-5.1,0.765,10,-1.7,2.84,-1.7,2.64,0.211,-8.6,1.2
ENSMUSG00000041471,FAM35A,"family with sequence similarity 35, member A",None,None,None,0,0,0,1,-3.2,2.77,-3.2,2.63,0.212,-6,1
ENSMUSG00000039748,EXO1,exonuclease 1,nucleus|,"DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|humoral immune response mediated by circulating immunoglobulin|DNA repair|mismatch repair|mismatch repair|mismatch repair|mismatch repair|DNA recombination|meiotic nuclear division|somatic hypermutation of immunoglobulin genes|isotype switching|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|",DNA binding|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|5'-3' exonuclease activity|5'-3' exodeoxyribonuclease activity|structure-specific DNA binding|single-stranded DNA 5'-3' exodeoxyribonuclease activity|metal ion binding|flap endonuclease activity|double-stranded DNA 5'-3' exodeoxyribonuclease activity|,1,0.3,0.0484,1,-4,3.29,-4,2.63,0.212,-8,0.7
ENSMUSG00000030435,U2AF2,U2 small nuclear RNA auxiliary factor 2,nucleus|nucleoplasm|spliceosomal complex|nuclear speck|,"mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|mRNA processing|mRNA export from nucleus|RNA splicing|gene expression|mRNA 3'-end processing|negative regulation of mRNA splicing, via spliceosome|",nucleotide binding|protein binding|enzyme binding|poly(A) RNA binding|C2H2 zinc finger domain binding|,9,-1.2,1.17,8,-3.4,2.47,-1.6,2.63,0.212,-6.5,2.9
ENSMUSG00000052684,JUN,jun proto-oncogene,nuclear chromosome|nucleoplasm|transcription factor complex|nuclear euchromatin|cytosol|transcriptional repressor complex|,"angiogenesis|microglial cell activation|release of cytochrome c from mitochondria|liver development|positive regulation of endothelial cell proliferation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|outflow tract morphogenesis|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|SMAD protein import into nucleus|aging|learning|circadian rhythm|negative regulation of cell proliferation|response to radiation|response to mechanical stimulus|monocyte differentiation|axon regeneration|negative regulation of protein autophosphorylation|positive regulation of Rho GTPase activity|response to lipopolysaccharide|response to cytokine|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|leading edge cell differentiation|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|response to drug|response to hydrogen peroxide|negative regulation of DNA binding|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|negative regulation by host of viral transcription|positive regulation by host of viral transcription|innate immune response|positive regulation of monocyte differentiation|positive regulation of DNA replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of smooth muscle cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|cellular response to potassium ion starvation|stress-activated MAPK cascade|response to cAMP|regulation of cell cycle|membrane depolarization|SMAD protein signal transduction|cellular response to calcium ion|",RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription coactivator activity|Rho GTPase activator activity|protein binding|transcription factor binding|enzyme binding|cAMP response element binding|transcription regulatory region DNA binding|poly(A) RNA binding|R-SMAD binding|HMG box domain binding|,10,2.1,5.04,10,-1.1,1.53,1.8,2.62,0.213,-4.2,5.6
ENSMUSG00000027868,TBX15,T-box 15,Tle3-Aes complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|embryonic cranial skeleton morphogenesis|",transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity|protein homodimerization activity|protein heterodimerization activity|,10,-1.1,0.828,10,-4.1,2.55,-1,2.62,0.213,-9.5,2.3
ENSMUSG00000017639,RAB11FIP4,RAB11 family interacting protein 4 (class II),extracellular space|endosome|endocytic vesicle|midbody|cleavage furrow|recycling endosome membrane|,cytokinesis|transport|viral process|,calcium ion binding|protein binding|Rab GTPase binding|ADP-ribosylation factor binding|protein homodimerization activity|,10,-1.9,1.84,10,-1.1,1.24,-1.7,2.62,0.213,-5.9,1.8
ENSMUSG00000038691,MBD3L1,methyl-CpG binding domain protein 3-like 1,nucleus|cytoplasm|plasma membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",None,1,2.8,2.83,1,-3.6,3.25,-3.6,2.62,0.213,-7,5.3
ENSMUSG00000022454,NELL2,NEL-like 2 (chicken),extracellular region|,None,calcium ion binding|protein binding|,10,-4.4,1.32,10,-2.7,1.66,-2.9,2.62,0.213,-8,2.6
ENSMUSG00000038122,TBC1D32,"TBC1 domain family, member 32",cytoplasm|cilium|,multicellular organismal development|positive regulation of Rab GTPase activity|,Rab GTPase activator activity|,0,0,0,1,-3.2,2.75,-3.2,2.61,0.214,-6,1
ENSMUSG00000032849,ABCC4,"ATP-binding cassette, sub-family C (CFTR/MRP), member 4",plasma membrane|plasma membrane|membrane|integral component of membrane|platelet dense granule membrane|platelet dense granule membrane|,platelet degranulation|ATP catabolic process|blood coagulation|biological_process|platelet activation|transmembrane transport|oxidation-reduction process|,"ATP binding|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATPase activity, coupled to transmembrane movement of substances|",10,-1.1,1.6,10,-1,1.21,-1.1,2.61,0.214,-5.2,1.9
ENSMUSG00000052102,GNPDA1,glucosamine-6-phosphate deaminase 1,cytoplasm|extracellular vesicular exosome|,carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine metabolic process|generation of precursor metabolites and energy|single fertilization|,glucosamine-6-phosphate deaminase activity|hydrolase activity|,1,1.1,0.452,1,-4.1,3.27,-4.1,2.61,0.214,-8,1.7
ENSMUSG00000054611,KDM2A,lysine (K)-specific demethylase 2A,nuclear chromatin|nucleus|nucleoplasm|nucleolus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|oxidation-reduction process|histone H3-K36 demethylation|",zinc ion binding|unmethylated CpG binding|histone demethylase activity (H3-K36 specific)|,1,0.5,0.101,1,-3.6,3.23,-3.6,2.61,0.214,-7,0.8
ENSMUSG00000031701,DNAJA2,"DnaJ (Hsp40) homolog, subfamily A, member 2",cytosol|membrane|extracellular vesicular exosome|,positive regulation of cell proliferation|response to heat|protein refolding|,protein binding|ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding|chaperone binding|,10,5.5,3.67,10,1.2,0.243,1.1,2.61,0.214,-0.7,10.4
ENSMUSG00000074846,GM10774,polymerase (RNA) II (DNA directed) polypeptide L pseudogene,None,None,None,1,0,0,1,-4.3,3.27,-4.3,2.61,0.214,-8,0.6
ENSMUSG00000021466,PTCH1,patched 1,Golgi apparatus|plasma membrane|caveola|postsynaptic density|integral component of membrane|midbody|intracellular membrane-bounded organelle|dendritic growth cone|axonal growth cone|perinuclear region of cytoplasm|primary cilium|,negative regulation of transcription from RNA polymerase II promoter|branching involved in ureteric bud morphogenesis|neural tube closure|heart morphogenesis|smoothened signaling pathway|smoothened signaling pathway|regulation of mitotic cell cycle|brain development|epidermis development|regulation of smoothened signaling pathway|response to mechanical stimulus|organ morphogenesis|dorsal/ventral pattern formation|response to chlorate|positive regulation of cholesterol efflux|protein processing|spinal cord motor neuron differentiation|neural tube patterning|neural plate axis specification|embryonic limb morphogenesis|response to estradiol|response to retinoic acid|regulation of protein localization|limb morphogenesis|hindlimb morphogenesis|negative regulation of multicellular organism growth|response to drug|glucose homeostasis|negative regulation of sequence-specific DNA binding transcription factor activity|keratinocyte proliferation|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of cell division|pharyngeal system development|mammary gland duct morphogenesis|mammary gland epithelial cell differentiation|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cell differentiation involved in kidney development|somite development|cellular response to cholesterol|cellular response to cholesterol|renal system development|cell proliferation involved in metanephros development|protein targeting to plasma membrane|,patched binding|smoothened binding|protein binding|hedgehog receptor activity|heparin binding|cholesterol binding|cyclin binding|protein complex binding|hedgehog family protein binding|,10,0.9,1.05,9,-4,2.5,-4.1,2.6,0.215,-9,1.5
ENSMUSG00000044927,H1FX,"H1 histone family, member X",nucleosome|nucleus|nucleolus|,nucleosome assembly|,DNA binding|poly(A) RNA binding|,1,0,0,1,-4.3,3.27,-4.3,2.6,0.215,-8,0.7
ENSMUSG00000059991,NPTX2,neuronal pentraxin II,cellular_component|extracellular region|,synaptic transmission|,molecular_function|metal ion binding|,10,0.1,0.0147,10,3.1,4.95,1.6,2.6,0.215,-2.6,7
ENSMUSG00000005871,APC,adenomatous polyposis coli,kinetochore|nucleus|cytoplasm|centrosome|cytosol|cytoplasmic microtubule|plasma membrane|plasma membrane|cell-cell adherens junction|tight junction|lateral plasma membrane|lamellipodium|beta-catenin destruction complex|ruffle membrane|microtubule plus-end|axonal growth cone|,mitotic cytokinesis|kidney development|hair follicle development|protein complex assembly|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|negative regulation of microtubule depolymerization|cell cycle arrest|metaphase/anaphase transition of mitotic cell cycle|mitotic spindle assembly checkpoint|cell adhesion|axonogenesis|negative regulation of cell proliferation|axis specification|anterior/posterior pattern specification|dorsal/ventral pattern formation|proximal/distal pattern formation|cell migration|positive regulation of cell migration|positive regulation of epithelial cell differentiation|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|positive regulation of pseudopodium assembly|regulation of microtubule-based process|T cell differentiation in thymus|somatic stem cell maintenance|negative regulation of odontogenesis|positive regulation of apoptotic process|negative regulation of MAPK cascade|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|canonical Wnt signaling pathway involved in positive regulation of apoptotic process|regulation of osteoblast differentiation|regulation of osteoclast differentiation|positive regulation of protein catabolic process|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell adhesion|muscle cell cellular homeostasis|thymus development|regulation of nitrogen compound metabolic process|chromosome organization|positive regulation of cell division|regulation of attachment of spindle microtubules to kinetochore|regulation of attachment of spindle microtubules to kinetochore|retina development in camera-type eye|canonical Wnt signaling pathway|canonical Wnt signaling pathway|negative regulation of epithelial cell proliferation involved in prostate gland development|tight junction assembly|negative regulation of canonical Wnt signaling pathway|,protein binding|beta-catenin binding|microtubule binding|protein kinase regulator activity|protein kinase binding|gamma-catenin binding|microtubule plus-end binding|,10,-2.5,2.41,10,3.5,4.47,3.3,2.6,0.215,-3.9,7.3
ENSMUSG00000060459,KNG2,kininogen 2,extracellular space|extracellular vesicular exosome|blood microparticle|,negative regulation of endopeptidase activity|,cysteine-type endopeptidase inhibitor activity|receptor binding|,10,-3.1,4.24,10,-0.8,0.305,-2.9,2.6,0.215,-9.1,2.7
ENSMUSG00000004296,IL12B,interleukin 12B,extracellular space|cytoplasm|membrane|interleukin-12 complex|interleukin-23 complex|,positive regulation of T cell mediated cytotoxicity|positive regulation of defense response to virus by host|positive regulation of defense response to virus by host|natural killer cell activation involved in immune response|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 1 type immune response|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|negative regulation of inflammatory response to antigenic stimulus|cell cycle arrest|response to UV-B|positive regulation of activation of JAK2 kinase activity|cell migration|cytokine-mediated signaling pathway|sensory perception of pain|sexual reproduction|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|positive regulation of natural killer cell activation|positive regulation of natural killer cell proliferation|positive regulation of mononuclear cell proliferation|positive regulation of tissue remodeling|positive regulation of smooth muscle cell apoptotic process|regulation of cytokine biosynthetic process|T-helper 1 type immune response|T-helper cell differentiation|interferon-gamma biosynthetic process|positive regulation of T cell proliferation|positive regulation of activated T cell proliferation|positive regulation of NF-kappaB import into nucleus|regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|defense response to protozoan|positive regulation of memory T cell differentiation|negative regulation of growth of symbiont in host|positive regulation of interferon-gamma biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of cell adhesion|negative regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NK T cell activation|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|defense response to virus|cellular response to lipopolysaccharide|cellular response to interferon-gamma|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 17 cell lineage commitment|,cytokine receptor activity|cytokine activity|interleukin-12 receptor binding|interleukin-12 receptor binding|protein binding|growth factor activity|interleukin-12 alpha subunit binding|identical protein binding|protein homodimerization activity|interleukin-23 receptor binding|protein heterodimerization activity|,10,2.2,4.16,10,-1.7,2.47,1.9,2.6,0.215,-5.6,5.7
ENSMUSG00000032300,1700017B05RIK,RIKEN cDNA 1700017B05 gene,cytoplasm|,biological_process|,molecular_function|,0,0,0,2,3.3,2.74,3.3,2.6,0.215,-2.8,7
ENSMUSG00000029250,POLR2B,"polymerase (RNA) II (DNA directed) polypeptide B, 140kDa","nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|membrane|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA splicing|gene expression|viral process|positive regulation of viral transcription|",DNA binding|chromatin binding|DNA-directed RNA polymerase activity|protein binding|ribonucleoside binding|poly(A) RNA binding|metal ion binding|,4,3.3,2.59,4,1.5,0.855,2.2,2.59,0.216,-6.4,8
ENSMUSG00000029233,SRD5A3,steroid 5 alpha-reductase 3,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,dolichol-linked oligosaccharide biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|androgen biosynthetic process|steroid metabolic process|polyprenol catabolic process|protein N-linked glycosylation via asparagine|dolichol metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|oxidation-reduction process|,"3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|cholestenone 5-alpha-reductase activity|",0,0,0,2,2.7,2.73,2.7,2.59,0.216,-0.9,6
ENSMUSG00000080725,GM6121,predicted gene 6121,cellular_component|,biological_process|,molecular_function|,2,-2.9,2.48,4,3.9,3.66,3.8,2.59,0.216,-4.8,8
ENSMUSG00000042472,ZFP410,zinc finger protein 410,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",nucleic acid binding|DNA binding|metal ion binding|,1,2.1,1.63,1,-4.3,3.26,-4.3,2.59,0.216,-8,4
ENSMUSG00000027748,TRPC4,"transient receptor potential cation channel, subfamily C, member 4",plasma membrane|plasma membrane|caveola|cell-cell junction|cell surface|basolateral plasma membrane|cortical cytoskeleton|calcium channel complex|,calcium ion transport|axon guidance|gamma-aminobutyric acid secretion|ion transmembrane transport|transmembrane transport|calcium ion import|calcium ion transmembrane transport|,"protein binding|beta-catenin binding|store-operated calcium channel activity|cadherin binding|inositol 1,4,5 trisphosphate binding|",9,-2.7,2.44,9,-3.5,0.384,-2.8,2.59,0.216,-9.1,1.5
ENSMUSG00000064063,BC048507,cDNA sequence BC048507,cellular_component|,biological_process|,molecular_function|,1,-4,2.24,1,-2.3,0.834,-3.8,2.59,0.216,-8,0.6
ENSMUSG00000041763,TPP2,tripeptidyl peptidase II,nucleus|cytoplasm|cytosol|,protein polyubiquitination|antigen processing and presentation of peptide antigen via MHC class I|proteolysis|,endopeptidase activity|aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity|,8,-2.5,0.0241,10,-1.5,2.84,-2.5,2.59,0.216,-7,1.9
ENSMUSG00000096620,GM5169,predicted gene 5169,cellular_component|,biological_process|,molecular_function|,2,-2.9,2.48,4,3.9,3.66,3.8,2.59,0.216,-4.8,8
ENSMUSG00000071788,GM14525,predicted gene 14525,cellular_component|,biological_process|,molecular_function|,2,-2.9,2.48,4,3.9,3.66,3.8,2.59,0.216,-4.8,8
ENSMUSG00000004558,NDRG2,NDRG family member 2,nucleus|cytoplasm|Golgi apparatus|centrosome|microtubule organizing center|cytosol|growth cone|perinuclear region of cytoplasm|extracellular vesicular exosome|,negative regulation of cytokine production|regulation of vascular endothelial growth factor production|Wnt signaling pathway|substantia nigra development|cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of ERK1 and ERK2 cascade|regulation of platelet-derived growth factor production|,molecular_function|protein binding|,1,2.7,2.72,0,0,0,2.7,2.58,0.217,-1,6
ENSMUSG00000032580,RBM5,RNA binding motif protein 5,nucleus|nucleoplasm|spliceosomal complex|,"spliceosomal complex assembly|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA processing|apoptotic process|negative regulation of cell proliferation|RNA splicing|gene expression|positive regulation of apoptotic process|positive regulation of apoptotic process|",nucleotide binding|DNA binding|RNA binding|mRNA binding|protein binding|zinc ion binding|poly(A) RNA binding|,10,-2.9,1.16,10,-1.2,2.16,-1.4,2.58,0.217,-8,3.2
ENSMUSG00000004698,HDAC9,histone deacetylase 9,histone deacetylase complex|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytoplasm|histone methyltransferase complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|inflammatory response|Notch signaling pathway|heart development|histone deacetylation|B cell differentiation|cellular response to insulin stimulus|peptidyl-lysine deacetylation|B cell activation|negative regulation of transcription, DNA-templated|regulation of skeletal muscle fiber development|regulation of striated muscle cell differentiation|histone H3 deacetylation|histone H4 deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|",transcription corepressor activity|histone deacetylase activity|protein kinase C binding|protein binding|transcription factor binding|transcription factor binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|histone deacetylase binding|histone deacetylase binding|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|repressing transcription factor binding|repressing transcription factor binding|repressing transcription factor binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,-1.7,1.54,10,-1,1.35,-1.5,2.58,0.217,-5.5,1.1
ENSMUSG00000035278,PLEKHJ1,"pleckstrin homology domain containing, family J member 1",None,None,None,10,-0.6,0.45,10,-1.7,2.82,-1.2,2.58,0.217,-4.8,2.5
ENSMUSG00000019471,CDC37,cell division cycle 37,cytoplasm|cytosol|ruffle membrane|protein complex|extracellular vesicular exosome|,regulation of cyclin-dependent protein serine/threonine kinase activity|protein targeting|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|,protein binding|heat shock protein binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|unfolded protein binding|chaperone binding|Hsp90 protein binding|,2,-1.8,1.01,6,-2.1,1.76,-2,2.57,0.218,-6,3
ENSMUSG00000021991,CACNA2D3,"calcium channel, voltage-dependent, alpha 2/delta subunit 3",integral component of membrane|,regulation of ion transmembrane transport|calcium ion transmembrane transport|,voltage-gated calcium channel activity|metal ion binding|,10,-4.9,3.5,10,-0.1,0.0146,-4.7,2.57,0.218,-9.6,1.4
ENSMUSG00000022346,MYC,v-myc avian myelocytomatosis viral oncogene homolog,nucleus|nucleoplasm|nucleoplasm|nucleolus|spindle|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal cell proliferation|energy reserve metabolic process|chromatin remodeling|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|cellular iron ion homeostasis|cellular response to DNA damage stimulus|cell cycle arrest|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|positive regulation of cell proliferation|response to gamma radiation|gene expression|regulation of gene expression|oxygen transport|regulation of telomere maintenance|negative regulation of stress-activated MAPK cascade|cellular response to UV|cellular response to drug|response to drug|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|fibroblast apoptotic process|negative regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of fibroblast proliferation|negative regulation of fibroblast proliferation|positive regulation of epithelial cell proliferation|chromosome organization|negative regulation of cell division|canonical Wnt signaling pathway|response to growth factor|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of DNA biosynthetic process|positive regulation of response to DNA damage stimulus|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein complex binding|protein dimerization activity|repressing transcription factor binding|E-box binding|,9,-1.5,0.13,9,-3.4,3.42,-2.3,2.57,0.218,-7.6,0.9
ENSMUSG00000031887,TRADD,TNFRSF1A-associated via death domain,nucleus|cytoplasm|cytosol|cytoskeleton|death-inducing signaling complex|receptor complex|membrane raft|,apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|tumor necrosis factor-mediated signaling pathway|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of NF-kappaB transcription factor activity|protein heterooligomerization|positive regulation of hair follicle development|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|,"signal transducer activity|tumor necrosis factor receptor binding|protein binding|kinase binding|protein complex binding|identical protein binding|binding, bridging|death domain binding|",10,-1.1,0.795,10,-1.4,2.05,-1.2,2.57,0.218,-4.3,3
ENSMUSG00000051355,COMMD1,copper metabolism (Murr1) domain containing 1,nucleus|cytoplasm|Cul2-RING ubiquitin ligase complex|extracellular vesicular exosome|,positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|copper ion homeostasis|,copper ion binding|protein binding|identical protein binding|protein homodimerization activity|,5,-5.2,0.378,5,-1.8,2.96,-2.5,2.57,0.218,-9.8,0.6
ENSMUSG00000059669,TAF1B,"TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa",nucleus|nucleoplasm|extracellular vesicular exosome|RNA polymerase I core factor complex|,"RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|gene expression|",RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|TBP-class protein binding|metal ion binding|,10,-1.2,1.51,10,-4,1.65,-3,2.57,0.218,-8.1,0.8
ENSMUSG00000049691,NKX3-2,NK3 homeobox 2,nucleus|,"skeletal system development|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|determination of left/right symmetry|pancreas development|negative regulation of chondrocyte differentiation|middle ear morphogenesis|negative regulation of apoptotic process|spleen development|organ formation|skeletal system morphogenesis|embryonic skeletal system development|intestinal epithelial cell development|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,9,2.3,3.11,9,-1.6,1.38,1.8,2.57,0.218,-4.3,6.6
ENSMUSG00000031734,IRX3,iroquois homeobox 3,nucleus|cytoplasm|axon|,"metanephros development|transcription, DNA-templated|regulation of transcription, DNA-templated|mesoderm development|negative regulation of neuron differentiation|positive regulation of neuron differentiation|specification of loop of Henle identity|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-5.3,2.7,0,0,0,-5.3,2.56,0.219,-10,0.6
ENSMUSG00000032575,MANF,mesencephalic astrocyte-derived neurotrophic factor,extracellular space|nucleus|perinuclear region of cytoplasm|,vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure|response to unfolded protein|biological_process|,growth factor activity|poly(A) RNA binding|,1,-5.1,2.7,0,0,0,-5.1,2.56,0.219,-10,0.6
ENSMUSG00000019066,RAB3D,"RAB3D, member RAS oncogene family",mitochondrion|plasma membrane|transport vesicle|zymogen granule|extracellular vesicular exosome|,GTP catabolic process|exocytosis|small GTPase mediated signal transduction|protein transport|regulation of exocytosis|peptidyl-cysteine methylation|,GTPase activity|GTP binding|GTPase binding|,10,-1.4,0.912,10,-1.9,2.06,-1.6,2.56,0.219,-6.1,2.5
ENSMUSG00000031508,ANKRD10,ankyrin repeat domain 10,None,None,None,1,0.2,0.0258,1,-3.5,3.16,-3.5,2.55,0.22,-7,0.8
ENSMUSG00000029561,OASL2,2'-5' oligoadenylate synthetase-like 2,cellular_component|,immune system process|purine nucleotide biosynthetic process|immune response|response to virus|innate immune response|defense response to virus|,nucleotide binding|2'-5'-oligoadenylate synthetase activity|RNA binding|double-stranded RNA binding|ATP binding|transferase activity|nucleotidyltransferase activity|metal ion binding|,9,-2.9,2.52,9,-1,1.37,-2.7,2.55,0.22,-7.5,2.6
ENSMUSG00000038644,POLD1,"polymerase (DNA directed), delta 1, catalytic subunit",nucleotide-excision repair complex|nucleus|nucleoplasm|cytoplasm|membrane|aggresome|delta DNA polymerase complex|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA synthesis involved in DNA repair|DNA synthesis involved in DNA repair|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|base-excision repair, gap-filling|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|nucleotide-excision repair, DNA gap filling|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|telomere maintenance via semi-conservative replication|DNA replication, removal of RNA primer|small molecule metabolic process|DNA replication proofreading|fatty acid homeostasis|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|","nucleotide binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|protein binding|3'-5' exonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding|",7,0.2,0.00965,10,-1.9,3.29,-1.8,2.55,0.22,-7.5,5.2
ENSMUSG00000001521,TULP3,tubby like protein 3,extracellular region|nucleus|nucleus|nucleolus|cytoplasm|plasma membrane|plasma membrane|cilium|intraciliary transport particle A|primary cilium|ciliary base|,"regulation of transcription, DNA-templated|G-protein coupled receptor signaling pathway|multicellular organismal development|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of smoothened signaling pathway|","protein binding|phosphatidylinositol-4,5-bisphosphate binding|enzyme binding|protein complex binding|phosphatidylinositol binding|",10,0,0,10,-2.9,3.36,-3.3,2.55,0.22,-9,1.1
ENSMUSG00000075040,ZFP408,zinc finger protein 408,cellular_component|,biological_process|,identical protein binding|,1,2.7,2.69,0,0,0,2.7,2.55,0.22,-1,6
ENSMUSG00000094447,9430069I07RIK,RIKEN cDNA 9430069I07 gene,cellular_component|,biological_process|,molecular_function|,1,-5.1,2.69,0,0,0,-5.1,2.55,0.22,-10,0.6
ENSMUSG00000042331,SPECC1,sperm antigen with calponin homology and coiled-coil domains 1,nucleus|,cell adhesion|,None,10,-2,0.74,10,-1.2,2.09,-1.9,2.55,0.22,-6.4,1.8
ENSMUSG00000048796,CYB561D1,"cytochrome b561 family, member D1",integral component of membrane|,oxidation-reduction process|,metal ion binding|,0,0,0,1,3,2.68,3,2.54,0.221,-1,6
ENSMUSG00000063884,PTCD3,pentatricopeptide repeat domain 3,mitochondrion|,regulation of translation|mitochondrial translation|,rRNA binding|ribosomal small subunit binding|poly(A) RNA binding|,0,0,0,2,2.8,2.68,2.8,2.54,0.221,-0.9,6
ENSMUSG00000031478,NEK3,NIMA-related kinase 3,nucleus|cytoplasm|axon|,protein phosphorylation|mitotic nuclear division|,protein serine/threonine kinase activity|protein binding|ATP binding|metal ion binding|,10,1.6,1.86,10,1.2,0.945,1.3,2.54,0.221,-5.7,5.8
ENSMUSG00000025034,TRIM8,tripartite motif containing 8,nucleus|cytoplasm|PML body|intracellular membrane-bounded organelle|,protein ubiquitination|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|negative regulation of viral release from host cell|,zinc ion binding|ligase activity|identical protein binding|protein homodimerization activity|,1,-5.3,2.68,0,0,0,-5.3,2.54,0.221,-10,0.6
ENSMUSG00000048626,KLF17,Kruppel-like factor 17,nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|gamete generation|",sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|metal ion binding|,1,-5.4,2.68,0,0,0,-5.4,2.54,0.221,-10,0.6
ENSMUSG00000001524,GTF2H4,"general transcription factor IIH, polypeptide 4, 52kDa",core TFIIH complex|nucleoplasm|holo TFIIH complex|,"nucleotide-excision repair, DNA damage removal|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|gene expression|viral process|DNA duplex unwinding|positive regulation of viral transcription|",sequence-specific DNA binding transcription factor activity|ATP-dependent DNA helicase activity|protein kinase activity|protein binding|DNA-dependent ATPase activity|RNA polymerase II carboxy-terminal domain kinase activity|,7,-2.9,3.12,8,-0.9,0.84,-2.5,2.54,0.221,-6.8,2.1
ENSMUSG00000022978,MIS18A,MIS18 kinetochore protein A,"chromosome, centromeric region|nucleus|nucleoplasm|cytoplasm|",nucleosome assembly|chromosome segregation|mitotic nuclear division|biological_process|centromere-specific nucleosome assembly|regulation of DNA methylation|,molecular_function|,1,-5,2.67,0,0,0,-5,2.53,0.222,-10,0.6
ENSMUSG00000046441,CMTR2,cap methyltransferase 2,nucleus|cytoplasm|integral component of membrane|,7-methylguanosine mRNA capping|cap2 mRNA methylation|,mRNA (nucleoside-2'-O-)-methyltransferase activity|,1,-5,2.67,0,0,0,-5,2.53,0.222,-10,0.6
ENSMUSG00000018736,NDEL1,nudE neurodevelopment protein 1-like 1,kinetochore|condensed chromosome kinetochore|nuclear envelope|nucleolus|cytoplasm|centrosome|spindle|cytosol|kinesin complex|microtubule|axon|cell leading edge|cell body|neurofilament cytoskeleton|,microtubule cytoskeleton organization|mitotic cell cycle|neuron migration|inner cell mass cell proliferation|proteolysis|chromosome segregation|retrograde axon cargo transport|cerebral cortex radially oriented cell migration|central nervous system neuron axonogenesis|activation of Cdc42 GTPase activity|positive regulation of axon extension|vesicle transport along microtubule|positive regulation of axon regeneration|nuclear envelope disassembly|centrosome localization|neurofilament cytoskeleton organization|,protein binding|microtubule binding|alpha-tubulin binding|beta-tubulin binding|oligopeptidase activity|,10,-2.2,2.05,10,-1,0.991,-1.5,2.53,0.222,-5.2,1.9
ENSMUSG00000090210,ITGA10,"integrin, alpha 10",plasma membrane|integrin complex|,cell-matrix adhesion|integrin-mediated signaling pathway|axon guidance|blood coagulation|extracellular matrix organization|,collagen binding|metal ion binding|,0,0,0,1,-3.2,2.67,-3.2,2.53,0.222,-6,1
ENSMUSG00000095063,SLX,Sycp3 like X-linked,XY body|nucleus|cytoplasm|,single fertilization|sex determination|regulation of gene expression|spermatid differentiation|,None,2,-5,3.31,2,1.9,0.689,-4.9,2.53,0.222,-10,2.3
ENSMUSG00000041362,4930506M07RIK,RIKEN cDNA 4930506M07 gene,microtubule|growth cone|cell projection|axonal growth cone|,multicellular organismal development|axonogenesis|neuron projection morphogenesis|membrane depolarization|regulation of establishment of cell polarity|regulation of neuron migration|,protein binding|kinase binding|,10,-0.7,0.796,10,-3.3,2.28,-0.9,2.53,0.222,-8.5,1
ENSMUSG00000025929,IL17A,interleukin 17A,extracellular space|external side of plasma membrane|,protein glycosylation|apoptotic process|inflammatory response|immune response|cell-cell signaling|cell death|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|cellular response to interleukin-1|fibroblast activation|positive regulation of cytokine production involved in inflammatory response|,cytokine activity|,10,-3.9,3.29,10,2.7,5.12,2.4,2.52,0.223,-6.4,7.5
ENSMUSG00000028978,NOS3,nitric oxide synthase 3 (endothelial cell),Golgi membrane|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|caveola|endocytic vesicle membrane|,angiogenesis|ovulation from ovarian follicle|in utero embryonic development|blood vessel remodeling|regulation of sodium ion transport|regulation of the force of heart contraction by chemical signal|regulation of systemic arterial blood pressure by endothelin|arginine catabolic process|nitric oxide biosynthetic process|mitochondrion organization|nitric oxide mediated signal transduction|blood coagulation|regulation of blood pressure|negative regulation of cell proliferation|response to heat|negative regulation of platelet activation|negative regulation of muscle hyperplasia|smooth muscle hyperplasia|lung development|positive regulation of guanylate cyclase activity|positive regulation of guanylate cyclase activity|lipopolysaccharide-mediated signaling pathway|response to fluid shear stress|negative regulation of potassium ion transport|endothelial cell migration|small molecule metabolic process|positive regulation of angiogenesis|negative regulation of blood pressure|positive regulation of vasodilation|nitric oxide metabolic process|regulation of blood vessel size|regulation of blood vessel size|regulation of nitric-oxide synthase activity|negative regulation of hydrolase activity|interaction with host|negative regulation of calcium ion transport|oxidation-reduction process|phagosome maturation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|,actin monomer binding|NADPH-hemoprotein reductase activity|nitric-oxide synthase activity|iron ion binding|protein binding|calmodulin binding|FMN binding|heme binding|tetrahydrobiopterin binding|arginine binding|cadmium ion binding|flavin adenine dinucleotide binding|NADP binding|,10,1.1,1.11,10,1.7,1.73,1.3,2.52,0.223,-3.9,6
ENSMUSG00000074731,ZFP345,zinc finger protein 345,cellular_component|,"regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|metal ion binding|,1,2.7,2.65,0,0,0,2.7,2.52,0.223,-1,6
ENSMUSG00000034274,THOC5,THO complex 5,transcription export complex|THO complex|THO complex part of transcription export complex|nucleus|cytoplasm|nuclear speck|,"mRNA processing|mRNA export from nucleus|RNA splicing|monocyte differentiation|positive regulation of DNA-templated transcription, elongation|negative regulation of macrophage differentiation|viral mRNA export from host cell nucleus|primitive hemopoiesis|negative regulation of DNA damage checkpoint|",RNA binding|protein binding|,8,2.5,3.81,9,-0.8,0.76,-2.1,2.51,0.224,-5.5,5.6
ENSMUSG00000042417,CCNO,cyclin O,nucleoplasm|nucleoplasm|,"regulation of cyclin-dependent protein serine/threonine kinase activity|DNA repair|base-excision repair|base-excision repair|base-excision repair, AP site formation|cell cycle|embryo development|response to drug|depyrimidination|cell division|",uracil DNA N-glycosylase activity|protein kinase binding|,10,-2.8,1.81,10,-1.5,1.48,-1.8,2.51,0.224,-5.7,2.8
ENSMUSG00000000440,PPARG,peroxisome proliferator-activated receptor gamma,nucleus|nucleoplasm|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|placenta development|negative regulation of acute inflammatory response|transcription initiation from RNA polymerase II promoter|lipid metabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|G-protein coupled receptor signaling pathway|heart development|response to nutrient|regulation of blood pressure|response to cold|gene expression|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|long-chain fatty acid transport|fatty acid oxidation|monocyte differentiation|negative regulation of cell growth|epithelial cell differentiation|response to caffeine|organ regeneration|response to retinoic acid|cellular response to insulin stimulus|response to vitamin A|response to lipid|peroxisome proliferator activated receptor signaling pathway|response to drug|glucose homeostasis|lipoprotein transport|steroid hormone mediated signaling pathway|response to estrogen|innate immune response|cell fate commitment|positive regulation of fat cell differentiation|low-density lipoprotein particle receptor biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid oxidation|cell maturation|negative regulation of smooth muscle cell proliferation|positive regulation of oligodendrocyte differentiation|white fat cell differentiation|white fat cell differentiation|brown fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|lipid homeostasis|response to low-density lipoprotein particle|negative regulation of interferon-gamma-mediated signaling pathway|regulation of cholesterol transporter activity|regulation of transcription involved in cell fate commitment|cellular response to lithium ion|",RNA polymerase II regulatory region DNA binding|DNA binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|prostaglandin receptor activity|protein binding|drug binding|zinc ion binding|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|transcription regulatory region DNA binding|retinoid X receptor binding|arachidonic acid binding|,10,-1.6,1.81,10,3.4,3.08,-1.5,2.51,0.224,-5.3,6.3
ENSMUSG00000022383,PPARA,peroxisome proliferator-activated receptor alpha,nucleus|nucleoplasm|,"negative regulation of transcription from RNA polymerase II promoter|response to hypoxia|transcription initiation from RNA polymerase II promoter|lipid metabolic process|fatty acid metabolic process|heart development|epidermis development|gene expression|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|fatty acid transport|intracellular receptor signaling pathway|intracellular receptor signaling pathway|positive regulation of fatty acid beta-oxidation|negative regulation of protein binding|negative regulation of appetite|response to insulin|circadian regulation of gene expression|behavioral response to nicotine|wound healing|lipoprotein metabolic process|regulation of circadian rhythm|steroid hormone mediated signaling pathway|cellular lipid metabolic process|small molecule metabolic process|negative regulation of blood pressure|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid oxidation|enamel mineralization|regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter|negative regulation of neuron death|negative regulation of transcription regulatory region DNA binding|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II repressing transcription factor binding|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|drug binding|zinc ion binding|lipid binding|phosphatase binding|protein domain specific binding|ubiquitin conjugating enzyme binding|protein complex binding|sequence-specific DNA binding|NFAT protein binding|MDM2/MDM4 family protein binding|,10,2.4,2.61,10,0.5,0.191,2.2,2.51,0.224,-5.3,7
ENSMUSG00000025142,ASPSCR1,"alveolar soft part sarcoma chromosome region, candidate 1",cellular_component|nucleus|cytosol|cytoplasmic side of plasma membrane|endomembrane system|vesicle membrane|extrinsic component of membrane|perinuclear region of cytoplasm|,intracellular protein transport|biological_process|glucose homeostasis|regulation of glucose import|membrane organization|,molecular_function|protein binding|,10,1.1,1.38,10,-1.5,2.72,-1.8,2.5,0.226,-5.9,2.8
ENSMUSG00000020361,HSPA4,heat shock 70kDa protein 4,mitochondrion|cytosol|extracellular vesicular exosome|,response to unfolded protein|protein import into mitochondrial outer membrane|chaperone-mediated protein complex assembly|,ATP binding|,10,-1.9,0.107,9,-2.9,3.07,-2.5,2.5,0.226,-7.6,1.6
ENSMUSG00000039828,WDR70,WD repeat domain 70,None,None,enzyme binding|,10,-1.6,1.78,10,-1.5,0.905,-1.5,2.5,0.226,-6.5,1
ENSMUSG00000046605,B3GNTL1,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1",None,metabolic process|,"transferase activity, transferring glycosyl groups|",1,-4.9,2.64,0,0,0,-4.9,2.5,0.226,-10,0.6
ENSMUSG00000017950,HNF4A,"hepatocyte nuclear factor 4, alpha",nucleus|nucleoplasm|cytoplasm|,"regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|ornithine metabolic process|lipid metabolic process|xenobiotic metabolic process|sex differentiation|blood coagulation|negative regulation of cell proliferation|response to glucose|gene expression|regulation of gastrulation|regulation of lipid metabolic process|signal transduction involved in regulation of gene expression|negative regulation of cell growth|intracellular receptor signaling pathway|endocrine pancreas development|glucose homeostasis|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of insulin secretion|lipid homeostasis|phospholipid homeostasis|SMAD protein signal transduction|regulation of growth hormone receptor signaling pathway|triglyceride homeostasis|positive regulation of cholesterol homeostasis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II activating transcription factor binding|DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|receptor binding|fatty acid binding|protein binding|zinc ion binding|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,-1.1,0.882,10,-1.6,1.93,-1.3,2.5,0.226,-4.3,3.4
ENSMUSG00000019969,PSEN1,presenilin 1,Golgi membrane|kinetochore|nuclear outer membrane|mitochondrion|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|centrosome|integral component of plasma membrane|cell cortex|cell surface|membrane|integral component of membrane|apical plasma membrane|Z disc|axon|growth cone|cytoplasmic vesicle|neuromuscular junction|nuclear membrane|ciliary rootlet|neuronal cell body|dendritic shaft|membrane raft|membrane raft|perinuclear region of cytoplasm|gamma-secretase complex|,"autophagic vacuole assembly|negative regulation of transcription from RNA polymerase II promoter|activation of MAPKK activity|blood vessel development|cell fate specification|somitogenesis|neuron migration|positive regulation of receptor recycling|heart looping|hematopoietic progenitor cell differentiation|T cell activation involved in immune response|myeloid leukocyte differentiation|protein glycosylation|membrane protein ectodomain proteolysis|mitochondrial transport|cellular response to DNA damage stimulus|response to oxidative stress|negative regulation of epidermal growth factor-activated receptor activity|Notch signaling pathway|Notch receptor processing|Notch receptor processing|memory|post-embryonic development|protein transport|L-glutamate transport|choline transport|synaptic vesicle targeting|single organismal cell-cell adhesion|protein processing|cerebral cortex cell migration|Cajal-Retzius cell differentiation|dorsal/ventral neural tube patterning|extracellular matrix disassembly|extracellular matrix organization|embryonic limb morphogenesis|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum calcium ion homeostasis|beta-amyloid formation|intracellular signal transduction|regulation of phosphorylation|anagen|amyloid precursor protein catabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|regulation of protein binding|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|skin morphogenesis|regulation of synaptic plasticity|thymus development|neuron development|skeletal system morphogenesis|brain morphogenesis|beta-amyloid metabolic process|epithelial cell proliferation|negative regulation of axonogenesis|positive regulation of coagulation|T cell receptor signaling pathway|neuron apoptotic process|negative regulation of ubiquitin-protein transferase activity|smooth endoplasmic reticulum calcium ion homeostasis|regulation of synaptic transmission, glutamatergic|canonical Wnt signaling pathway|regulation of resting membrane potential|calcium ion transmembrane transport|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway|",endopeptidase activity|aspartic-type endopeptidase activity|calcium channel activity|protein binding|beta-catenin binding|PDZ domain binding|cadherin binding|,9,0.3,0.0621,10,-2.3,3.32,-2.2,2.5,0.226,-7.7,2.8
ENSMUSG00000026617,BPNT1,"3'(2'), 5'-bisphosphate nucleotidase 1",cytosol|extracellular vesicular exosome|,nucleobase-containing compound metabolic process|xenobiotic metabolic process|nervous system development|dephosphorylation|dephosphorylation|small molecule metabolic process|phosphatidylinositol phosphorylation|3'-phosphoadenosine 5'-phosphosulfate metabolic process|,"magnesium ion binding|inositol-1,4-bisphosphate 1-phosphatase activity|3'(2'),5'-bisphosphate nucleotidase activity|",10,-3.8,4.1,10,-0.7,0.37,-3.6,2.49,0.227,-7.1,0.8
ENSMUSG00000054477,KCNN2,"potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2",smooth endoplasmic reticulum|plasma membrane|plasma membrane|integral component of membrane|Z disc|T-tubule|neuronal cell body|dendritic spine|,potassium ion transport|synaptic transmission|potassium ion transmembrane transport|regulation of potassium ion transmembrane transport|,calmodulin binding|calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|protein homodimerization activity|alpha-actinin binding|,1,-4.9,2.62,0,0,0,-4.9,2.48,0.228,-10,0.6
ENSMUSG00000031822,GSE1,Gse1 coiled-coil protein,None,None,protein binding|,9,-3.3,2.07,8,-1.7,1.16,-3.2,2.48,0.228,-7.3,1.2
ENSMUSG00000053852,GPR112,G protein-coupled receptor 112,plasma membrane|integral component of membrane|,G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|,G-protein coupled receptor activity|,10,-1.5,2.09,9,-2.4,0.779,-1.6,2.47,0.229,-7.2,6.8
ENSMUSG00000020802,UBE2O,ubiquitin-conjugating enzyme E2O,nucleus|cytoplasm|,"protein monoubiquitination|positive regulation of BMP signaling pathway|retrograde transport, endosome to Golgi|protein K63-linked ubiquitination|",ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|poly(A) RNA binding|,10,-4.3,3.78,10,-1.2,1.13,-1.8,2.47,0.229,-8,0.9
ENSMUSG00000045680,TCF21,transcription factor 21,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|branching involved in ureteric bud morphogenesis|morphogenesis of a branching structure|kidney development|vasculature development|transcription, DNA-templated|sex determination|branchiomeric skeletal muscle development|epithelial cell differentiation|glomerulus development|positive regulation of transcription from RNA polymerase II promoter|lung alveolus development|spleen development|embryonic digestive tract morphogenesis|reproductive structure development|gland development|Sertoli cell differentiation|palate development|lung morphogenesis|lung vasculature development|bronchiole development|diaphragm development|respiratory system development|negative regulation of androgen receptor signaling pathway|metanephric mesenchymal cell differentiation|metanephric glomerular capillary formation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|histone deacetylase binding|bHLH transcription factor binding|protein dimerization activity|androgen receptor binding|E-box binding|,10,-1.3,3.38,10,0,0,-1.2,2.47,0.229,-5.9,1.9
ENSMUSG00000006585,CDT1,chromatin licensing and DNA replication factor 1,nucleus|nucleoplasm|cytosol|,DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|regulation of DNA-dependent DNA replication initiation|regulation of nuclear cell cycle DNA replication|,DNA binding|protein binding|,10,-3.5,3.39,10,2.7,0.998,-1.8,2.47,0.229,-9.1,5
ENSMUSG00000048915,EFNA5,ephrin-A5,plasma membrane|caveola|anchored component of external side of plasma membrane|,nervous system development|axon guidance|regulation of cell-cell adhesion|retinal ganglion cell axon guidance|regulation of Rac GTPase activity|regulation of Rho GTPase activity|regulation of actin cytoskeleton organization|ephrin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|regulation of focal adhesion assembly|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of microtubule cytoskeleton organization|,chemorepellent activity|ephrin receptor binding|,1,2.6,2.6,0,0,0,2.6,2.47,0.229,-1,6
ENSMUSG00000033685,UCP2,"uncoupling protein 2 (mitochondrial, proton carrier)",mitochondrial inner membrane|integral component of membrane|,response to superoxide|response to hypoxia|transport|mitochondrial transport|female pregnancy|aging|positive regulation of cell death|proton transport|respiratory electron transport chain|cellular response to insulin stimulus|cellular response to amino acid starvation|negative regulation of apoptotic process|cellular metabolic process|small molecule metabolic process|negative regulation of insulin secretion involved in cellular response to glucose stimulus|response to fatty acid|cellular response to glucose stimulus|liver regeneration|,None,10,-5.1,2.37,10,2.5,2.49,1.8,2.47,0.229,-7.5,6.1
ENSMUSG00000024578,IL17B,interleukin 17B,extracellular space|,inflammatory response|immune response|cell-cell signaling|positive regulation of cytokine production involved in inflammatory response|,cytokine activity|,8,-2.9,2.14,9,-1.4,1.32,-2.3,2.47,0.229,-7.8,6.9
ENSMUSG00000027889,AMPD2,adenosine monophosphate deaminase 2,cellular_component|cytosol|,purine nucleobase metabolic process|IMP biosynthetic process|IMP salvage|purine-containing compound salvage|small molecule metabolic process|cyclic purine nucleotide metabolic process|nucleobase-containing small molecule metabolic process|energy homeostasis|,AMP deaminase activity|AMP deaminase activity|metal ion binding|,10,0.9,1.3,10,-2.2,3.68,-1.8,2.47,0.229,-6.1,2.7
ENSMUSG00000022218,TGM1,transglutaminase 1,cornified envelope|cell-cell adherens junction|intrinsic component of membrane|extracellular vesicular exosome|,cellular protein modification process|organ morphogenesis|peptide cross-linking|keratinocyte differentiation|keratinization|cell envelope organization|,protein-glutamine gamma-glutamyltransferase activity|protein binding|metal ion binding|,10,-1.8,3.65,10,0,0,-1.5,2.47,0.229,-7,1.2
ENSMUSG00000025487,PSMD13,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 13",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|meiosis I|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",None,6,1.5,0.831,8,1.4,1.81,1.5,2.46,0.231,-4.2,5.8
ENSMUSG00000025982,SF3B1,"splicing factor 3b, subunit 1, 155kDa",nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nuclear speck|intracellular membrane-bounded organelle|catalytic step 2 spliceosome|,"RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA splicing|anterior/posterior pattern specification|gene expression|",chromatin binding|protein binding|poly(A) RNA binding|,0,0,0,1,3,2.6,3,2.46,0.231,-1.1,6
ENSMUSG00000051596,OTOP1,otopetrin 1,extracellular space|integral component of membrane|,detection of gravity|biomineral tissue development|inner ear morphogenesis|,None,10,-3.1,2.27,10,-0.9,0.5,-1.5,2.46,0.231,-6.2,1.8
ENSMUSG00000041540,SOX5,SRY (sex determining region Y)-box 5,nucleus|,"in utero embryonic development|transcription from RNA polymerase II promoter|central nervous system neuron differentiation|positive regulation of chondrocyte differentiation|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|oligodendrocyte differentiation|cartilage development|regulation of timing of neuron differentiation|positive regulation of cartilage development|cellular response to transforming growth factor beta stimulus|positive regulation of mesenchymal stem cell differentiation|",sequence-specific DNA binding transcription factor activity|protein binding|transcription regulatory region DNA binding|protein heterodimerization activity|,1,2.9,3.06,1,-2.6,1.44,2.8,2.46,0.231,-4.1,7
ENSMUSG00000040370,LYRM5,LYR motif containing 5,mitochondrion|,None,None,0,0,0,1,3,2.6,3,2.46,0.231,-1.1,6
ENSMUSG00000028909,PTPRU,"protein tyrosine phosphatase, receptor type, U",plasma membrane|integral component of plasma membrane|cell-cell junction|,protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|negative regulation of cell proliferation|single organismal cell-cell adhesion|cell differentiation|negative regulation of cell migration|organ regeneration|homotypic cell-cell adhesion|protein localization to cell surface|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|response to glucocorticoid|canonical Wnt signaling pathway|,protein tyrosine phosphatase activity|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|beta-catenin binding|,10,-0.5,0.347,10,-1.9,3.17,-1.6,2.46,0.231,-8.5,5
ENSMUSG00000019189,RNF145,ring finger protein 145,integral component of membrane|,None,zinc ion binding|,0,0,0,1,3,2.6,3,2.46,0.231,-1.1,6
ENSMUSG00000026526,FH1,fumarate hydratase 1,cytoplasm|mitochondrion|mitochondrion|tricarboxylic acid cycle enzyme complex|extracellular vesicular exosome|,tricarboxylic acid cycle|fumarate metabolic process|malate metabolic process|homeostasis of number of cells within a tissue|,catalytic activity|fumarate hydratase activity|lyase activity|,10,-1.4,1.95,10,-1.6,0.693,-1.5,2.45,0.232,-6.9,3.6
ENSMUSG00000053560,IER2,immediate early response 2,cytoplasm|,None,None,1,-4,2.23,1,-2.1,0.709,-3.8,2.45,0.232,-8,0.7
ENSMUSG00000031451,GAS6,growth arrest-specific 6,extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|platelet alpha granule lumen|extracellular vesicular exosome|,"neuron migration|positive regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of cytokine-mediated signaling pathway|platelet degranulation|positive regulation of glomerular filtration|protein phosphorylation|proteolysis|phagocytosis|cell cycle arrest|cell adhesion|signal transduction|signal transduction|enzyme linked receptor protein signaling pathway|blood coagulation|cell proliferation|cellular response to starvation|positive regulation of gene expression|negative regulation of tumor necrosis factor-mediated signaling pathway|macrophage cytokine production|cell migration|peptidyl-glutamic acid carboxylation|peptidyl-serine phosphorylation|fusion of virus membrane with host plasma membrane|viral genome replication|platelet activation|organ regeneration|cell-substrate adhesion|positive regulation of TOR signaling|activation of protein kinase B activity|negative regulation of interferon-gamma production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|positive regulation of peptidyl-serine phosphorylation|negative regulation of protein import into nucleus, translocation|cellular response to interferon-alpha|cellular response to drug|B cell chemotaxis|regulation of growth|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|apoptotic cell clearance|negative regulation of sequence-specific DNA binding transcription factor activity|protein kinase B signaling|post-translational protein modification|cellular protein metabolic process|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of protein export from nucleus|positive regulation of fibroblast proliferation|negative regulation of interleukin-1 secretion|positive regulation of phagocytosis|leukocyte migration|positive regulation of protein kinase B signaling|positive regulation of protein tyrosine kinase activity|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|platelet aggregation|calcium ion transmembrane transport|cellular response to vitamin K|cellular response to glucose stimulus|cellular response to growth factor stimulus|protein targeting to plasma membrane|extracellular matrix assembly|dendritic cell differentiation|hematopoietic stem cell migration to bone marrow|negative regulation of oligodendrocyte apoptotic process|negative regulation of interleukin-6 secretion|negative regulation of fibroblast apoptotic process|negative regulation of endothelial cell apoptotic process|positive regulation of dendritic cell chemotaxis|negative regulation of renal albumin absorption|negative regulation of dendritic cell apoptotic process|","phosphatidylserine binding|receptor binding|receptor binding|voltage-gated calcium channel activity|calcium ion binding|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|receptor agonist activity|binding, bridging|",10,2.8,5.29,10,-1.5,1.61,2.5,2.45,0.232,-4.6,9.1
ENSMUSG00000030016,ZFML,"zinc finger, matrin-like",nucleus|intracellular membrane-bounded organelle|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",nucleotide binding|nucleic acid binding|DNA binding|RNA binding|zinc ion binding|poly(A) RNA binding|metal ion binding|,1,-5.9,2.59,0,0,0,-5.9,2.45,0.232,-12,0.4
ENSMUSG00000066798,ZBTB6,zinc finger and BTB domain containing 6,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|metal ion binding|,1,2.6,2.59,0,0,0,2.6,2.45,0.232,-1.1,6
ENSMUSG00000014786,SLC9A5,"solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5",plasma membrane|integral component of membrane|,transport|ion transport|regulation of pH|sodium ion transmembrane transport|sodium ion transmembrane transport|transmembrane transport|hydrogen ion transmembrane transport|,sodium:proton antiporter activity|,1,-5.9,2.57,0,0,0,-5.9,2.44,0.233,-12,0.4
ENSMUSG00000025791,PGM2,phosphoglucomutase 2,cytosol|cytosol|,carbohydrate metabolic process|glycogen biosynthetic process|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|glucose metabolic process|galactose catabolic process|galactose catabolic process|small molecule metabolic process|deoxyribose phosphate catabolic process|,magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity|,9,-4.7,1.95,10,-1.7,1.64,-1.9,2.44,0.233,-8.8,4.6
ENSMUSG00000003429,RPS11,ribosomal protein S11,cytosol|ribosome|membrane|cytosolic small ribosomal subunit|extracellular vesicular exosome|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|cellular protein metabolic process|",structural constituent of ribosome|protein binding|rRNA binding|poly(A) RNA binding|,0,0,0,3,1.9,2.57,1.9,2.44,0.233,-1.2,4
ENSMUSG00000003604,AVEN,"apoptosis, caspase activation inhibitor",intracellular|endomembrane system|membrane|,apoptotic process|negative regulation of apoptotic process|,protein binding|,10,-0.4,0.167,10,-3,3.7,-2.2,2.44,0.233,-7.4,2.4
ENSMUSG00000038502,PTOV1,prostate tumor overexpressed 1,nucleus|plasma membrane|perinuclear region of cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",None,1,-4.8,2.57,0,0,0,-4.8,2.44,0.233,-9,0.7
ENSMUSG00000047238,MAGEH1,"melanoma antigen family H, 1",cytoplasm|,apoptotic process|,None,10,-3.7,5.17,9,0.9,0.409,-3.6,2.43,0.234,-9.3,2.1
ENSMUSG00000025318,JPH3,junctophilin 3,plasma membrane|junctional sarcoplasmic reticulum membrane|integral component of membrane|junctional membrane complex|,learning|memory|exploration behavior|locomotion|regulation of neuronal synaptic plasticity|neuromuscular process controlling balance|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol|calcium ion transmembrane transport|,molecular_function|calcium-release channel activity|,10,-1.9,3.22,10,-0.5,0.0668,-1.3,2.43,0.234,-5.4,1.3
ENSMUSG00000044897,OLFR821,olfactory receptor 821,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-5.7,2.57,0,0,0,-5.7,2.43,0.234,-11,0.6
ENSMUSG00000026495,EFCAB2,EF-hand calcium binding domain 2,None,None,calcium ion binding|,10,-6.1,4.57,10,-0.5,0.196,-1.1,2.43,0.234,-10.6,0.5
ENSMUSG00000057506,BLOC1S2,"biogenesis of lysosomal organelles complex-1, subunit 2",gamma-tubulin complex|nucleus|nucleus|mitochondrion|centrosome|centrosome|BLOC-1 complex|recycling endosome|,"microtubule nucleation|anterograde axon cargo transport|positive regulation of cell proliferation|extrinsic apoptotic signaling pathway via death domain receptors|neuron projection development|melanosome organization|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|anterograde synaptic vesicle transport|platelet dense granule organization|mitochondrial outer membrane permeabilization|",protein binding|protein C-terminus binding|protein C-terminus binding|gamma-tubulin binding|,10,2.1,3.89,10,0.1,0.0372,1.7,2.43,0.234,-6.7,6.8
ENSMUSG00000006005,TPR,"translocated promoter region, nuclear basket protein",kinetochore|kinetochore|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytoplasmic dynein complex|extrinsic component of membrane|nuclear membrane|nuclear periphery|nuclear inclusion body|nuclear pore nuclear basket|mitotic spindle|,negative regulation of transcription from RNA polymerase II promoter|MAPK import into nucleus|mitotic cell cycle|carbohydrate metabolic process|RNA import into nucleus|RNA export from nucleus|nuclear pore organization|mitotic nuclear division|mitotic nuclear envelope disassembly|mitotic spindle assembly checkpoint|hexose transport|regulation of glucose transport|regulation of mitotic sister chromatid separation|glucose transport|viral process|cytokine-mediated signaling pathway|positive regulation of heterochromatin assembly|mRNA export from nucleus in response to heat stress|cellular response to heat|cellular response to interferon-alpha|positive regulation of protein import into nucleus|small molecule metabolic process|negative regulation of translational initiation|positive regulation of protein export from nucleus|negative regulation of RNA export from nucleus|negative regulation of RNA export from nucleus|transmembrane transport|response to epidermal growth factor|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of intracellular protein transport|regulation of spindle assembly involved in mitosis|,chromatin binding|mRNA binding|nucleocytoplasmic transporter activity|protein binding|tubulin binding|heat shock protein binding|protein homodimerization activity|poly(A) RNA binding|mitogen-activated protein kinase binding|dynein complex binding|,10,-1.6,2.39,10,4.4,4.48,2.8,2.43,0.234,-3.9,9.9
ENSMUSG00000089669,TNFSF13,"tumor necrosis factor (ligand) superfamily, member 13",extracellular space|nucleoplasm|cytoplasm|cytosol|external side of plasma membrane|extracellular vesicular exosome|,immunoglobulin production in mucosal tissue|positive regulation of germinal center formation|signal transduction|positive regulation of cell proliferation|gene expression|RNA metabolic process|mRNA metabolic process|positive regulation of isotype switching to IgA isotypes|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|,10,-3.2,1.06,10,-3.1,1.54,-3.2,2.42,0.235,-7.1,2.1
ENSMUSG00000035274,TPBG,trophoblast glycoprotein,endoplasmic reticulum|integral component of plasma membrane|,cell adhesion|,None,10,-3.7,2.19,10,-1,1.08,-1.6,2.42,0.235,-7.1,1.3
ENSMUSG00000073878,GM13304,predicted gene 13304,cellular_component|,biological_process|,molecular_function|,10,-2.7,3,10,-0.8,0.506,-2.1,2.42,0.235,-7.2,4.6
ENSMUSG00000005686,AMPD3,adenosine monophosphate deaminase 3,cytosol|,purine nucleobase metabolic process|AMP catabolic process|IMP salvage|purine-containing compound salvage|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,AMP deaminase activity|metal ion binding|,10,5.9,5.66,10,0.1,0.00545,5.9,2.42,0.235,-0.6,12.6
ENSMUSG00000094065,GM21541,"predicted gene, 21541",None,None,None,10,-2.7,3,10,-0.8,0.506,-2.1,2.42,0.235,-7.2,4.6
ENSMUSG00000029851,FAM115C,"family with sequence similarity 115, member C",None,None,None,2,-3.1,2.56,0,0,0,-3.1,2.42,0.235,-7,0.9
ENSMUSG00000022817,ITGB5,"integrin, beta 5",plasma membrane|focal adhesion|integrin complex|cell leading edge|receptor complex|phagocytic vesicle|extracellular vesicular exosome|,"antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|muscle contraction|cell adhesion|integrin-mediated signaling pathway|multicellular organismal development|extracellular matrix organization|antigen processing and presentation of exogenous peptide antigen via MHC class I|",receptor activity|integrin binding|protein binding|,10,-1.8,2.11,10,-1.1,0.622,-1.6,2.42,0.235,-5,5.6
ENSMUSG00000096596,GM10591,predicted gene 10591,cellular_component|,biological_process|,molecular_function|,10,-2.7,3,10,-0.8,0.506,-2.1,2.42,0.235,-7.2,4.6
ENSMUSG00000007721,CCDC124,coiled-coil domain containing 124,cytoplasm|microtubule organizing center|plasma membrane|midbody|,cell cycle|cell division|,poly(A) RNA binding|,1,2.6,2.56,0,0,0,2.6,2.42,0.235,-1.1,6
ENSMUSG00000022020,NAA16,"N(alpha)-acetyltransferase 16, NatA auxiliary subunit",nucleus|transcription factor complex|cytoplasm|cytoplasm|NatA complex|extracellular vesicular exosome|,"N-terminal protein amino acid acetylation|N-terminal protein amino acid acetylation|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|protein stabilization|",peptide alpha-N-acetyltransferase activity|protein binding|acetyltransferase activity|ribosome binding|ribosome binding|,1,-4.7,2.55,0,0,0,-4.7,2.42,0.235,-9,0.8
ENSMUSG00000017718,AFMID,arylformamidase,nucleus|cytosol|,tryptophan catabolic process|tryptophan catabolic process to kynurenine|'de novo' NAD biosynthetic process from tryptophan|cellular nitrogen compound metabolic process|small molecule metabolic process|,arylformamidase activity|,10,-1.9,0.979,10,-1.4,1.75,-1.6,2.42,0.235,-5,1.7
ENSMUSG00000029029,WRAP73,"WD repeat containing, antisense to TP73",cytoplasm|centrosome|,None,None,1,2.6,2.56,0,0,0,2.6,2.42,0.235,-1.1,6
ENSMUSG00000095675,CCL21B,chemokine (C-C motif) ligand 21B (leucine),external side of plasma membrane|,leukocyte chemotaxis|negative regulation of myeloid cell differentiation|cell chemotaxis|,chemokine activity|chemokine activity|chemokine receptor binding|,10,-2.7,3,10,-0.8,0.506,-2.1,2.42,0.235,-7.2,4.6
ENSMUSG00000079002,C030006K11RIK,RIKEN cDNA C030006K11 gene,mitochondrion|,biological_process|,molecular_function|,0,0,0,2,2.4,2.55,2.4,2.42,0.235,-1.1,5
ENSMUSG00000060534,DCC,DCC netrin 1 receptor,cytosol|plasma membrane|integral component of membrane|axon|growth cone membrane|membrane raft|,neuron migration|response to amphetamine|apoptotic process|axonogenesis|axon guidance|positive regulation of neuron projection development|negative regulation of neuron projection development|spinal cord ventral commissure morphogenesis|dorsal/ventral axon guidance|anterior/posterior axon guidance|netrin-activated signaling pathway|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of collateral sprouting|positive regulation of ERK1 and ERK2 cascade|negative regulation of dendrite development|regulation of RNA biosynthetic process|,transcription coactivator activity|transmembrane signaling receptor activity|netrin receptor activity|protein binding|identical protein binding|,10,-3.2,3.1,10,-1,0.557,-3.1,2.41,0.236,-7.6,0.8
ENSMUSG00000037583,NR0B2,"nuclear receptor subfamily 0, group B, member 2",nucleus|nucleoplasm|cytoplasm|protein complex|,negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|cholesterol metabolic process|response to glucose|gene expression|androgen receptor signaling pathway|organ regeneration|positive regulation of insulin secretion|steroid hormone mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|,DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|protein binding|protein domain specific binding|protein complex binding|protein homodimerization activity|peroxisome proliferator activated receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|,10,-3.7,0.968,10,-0.9,1.64,-0.9,2.41,0.236,-9.4,1.8
ENSMUSG00000028152,TSPAN5,tetraspanin 5,plasma membrane|integral component of membrane|,positive regulation of Notch signaling pathway|protein maturation|establishment of protein localization to plasma membrane|,enzyme binding|,1,-5.2,2.7,1,-1.6,0.356,-5,2.41,0.236,-10,0.5
ENSMUSG00000022235,CMBL,carboxymethylenebutenolidase homolog (Pseudomonas),cytosol|extracellular vesicular exosome|,metabolic process|,hydrolase activity|,10,-3.5,1.64,10,-0.9,1.47,-1.4,2.41,0.236,-8.2,2.4
ENSMUSG00000040734,PPP1R13L,"protein phosphatase 1, regulatory subunit 13 like",nucleus|cytoplasm|cell junction|,"negative regulation of transcription from RNA polymerase II promoter|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|transcription, DNA-templated|apoptotic process|post-embryonic development|embryonic camera-type eye development|multicellular organism growth|hair cycle|multicellular organismal homeostasis|cardiac muscle contraction|",transcription corepressor activity|protein binding|transcription factor binding|identical protein binding|,10,-3.3,0.563,10,1.6,3.03,1.3,2.41,0.236,-6.3,4.9
ENSMUSG00000036390,GADD45A,"growth arrest and DNA-damage-inducible, alpha",nucleus|cytoplasm|,regulation of cyclin-dependent protein serine/threonine kinase activity|activation of MAPKKK activity|DNA repair|negative regulation of protein kinase activity|apoptotic process|cell cycle arrest|centrosome cycle|signal transduction in response to DNA damage|positive regulation of apoptotic process|positive regulation of JNK cascade|cellular response to mechanical stimulus|cellular response to ionizing radiation|positive regulation of p38MAPK cascade|positive regulation of reactive oxygen species metabolic process|,core promoter binding|protein binding|,10,-0.7,0.52,10,3,3.33,2.2,2.41,0.236,-3.3,6.3
ENSMUSG00000028047,THBS3,thrombospondin 3,extracellular region|perinuclear region of cytoplasm|,growth plate cartilage development|cell-matrix adhesion|ossification involved in bone maturation|bone trabecula formation|,calcium ion binding|heparin binding|,10,-3.6,4.85,10,0.6,0.145,-3.4,2.4,0.237,-6.8,1.3
ENSMUSG00000029373,PF4,platelet factor 4,extracellular region|extracellular region|extracellular region|extracellular space|platelet alpha granule lumen|,platelet degranulation|immune response|blood coagulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|negative regulation of angiogenesis|cytokine-mediated signaling pathway|platelet activation|platelet activation|leukocyte chemotaxis|positive regulation of cAMP metabolic process|positive regulation of tumor necrosis factor production|regulation of cell proliferation|positive regulation of cAMP-mediated signaling|negative regulation of MHC class II biosynthetic process|positive regulation of macrophage differentiation|negative regulation of megakaryocyte differentiation|negative regulation of cytolysis|positive regulation of transcription from RNA polymerase II promoter|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,chemokine activity|heparin binding|CXCR3 chemokine receptor binding|,10,-1.9,2.25,10,-0.6,0.882,-2.2,2.4,0.237,-7.2,3.6
ENSMUSG00000070844,VMN2R42,"vomeronasal 2, receptor 42",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,4,-3.3,1.21,4,-4.8,1.69,-3.6,2.4,0.237,-8.9,3.5
ENSMUSG00000022982,SOD1,"superoxide dismutase 1, soluble",extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|peroxisome|peroxisome|cytosol|cytosol|plasma membrane|extracellular matrix|cytoplasmic vesicle|dendrite cytoplasm|neuronal cell body|protein complex|extracellular vesicular exosome|,activation of MAPK activity|response to superoxide|ovarian follicle development|positive regulation of cytokine production|placenta development|retina homeostasis|response to amphetamine|myeloid cell homeostasis|platelet degranulation|glutathione metabolic process|superoxide metabolic process|superoxide metabolic process|cellular iron ion homeostasis|spermatogenesis|embryo implantation|embryo implantation|cell aging|blood coagulation|sensory perception of sound|locomotory behavior|anterograde axon cargo transport|retrograde axon cargo transport|regulation of blood pressure|cell death|response to heat|response to organic substance|transmission of nerve impulse|removal of superoxide radicals|removal of superoxide radicals|removal of superoxide radicals|platelet activation|response to nutrient levels|peripheral nervous system myelin maintenance|regulation of Rac GTPase activity|positive regulation of superoxide anion generation|regulation of T cell differentiation in thymus|regulation of multicellular organism growth|response to drug|response to hydrogen peroxide|superoxide anion generation|positive regulation of apoptotic process|positive regulation of catalytic activity|negative regulation of neuron apoptotic process|response to ethanol|negative regulation of cholesterol biosynthetic process|regulation of protein kinase activity|regulation of organ growth|response to copper ion|muscle cell cellular homeostasis|thymus development|response to axon injury|hydrogen peroxide biosynthetic process|hydrogen peroxide biosynthetic process|regulation of mitochondrial membrane potential|oxidation-reduction process|heart contraction|neurofilament cytoskeleton organization|relaxation of vascular smooth muscle|auditory receptor cell stereocilium organization|reactive oxygen species metabolic process|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|,superoxide dismutase activity|superoxide dismutase activity|superoxide dismutase activity|copper ion binding|protein binding|zinc ion binding|protein phosphatase 2B binding|identical protein binding|protein homodimerization activity|Rac GTPase binding|chaperone binding|,0,0,0,3,2.3,2.53,2.3,2.4,0.237,-1.2,5
ENSMUSG00000031639,TLR3,toll-like receptor 3,Golgi membrane|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|integral component of plasma membrane|endosome membrane|membrane|endolysosome membrane|,toll-like receptor signaling pathway|microglial cell activation involved in immune response|MyD88-independent toll-like receptor signaling pathway|inflammatory response|hyperosmotic response|signal transduction|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|male gonad development|detection of virus|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|positive regulation of type III interferon production|cellular response to interferon-beta|TRIF-dependent toll-like receptor signaling pathway|cellular response to drug|positive regulation of NF-kappaB import into nucleus|defense response to bacterium|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|positive regulation of interferon-gamma biosynthetic process|positive regulation of chemokine biosynthetic process|innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta biosynthetic process|negative regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|defense response to virus|pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response|cellular response to mechanical stimulus|cellular response to interferon-gamma|cellular response to exogenous dsRNA|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|,double-stranded RNA binding|double-stranded RNA binding|receptor activity|transmembrane signaling receptor activity|protein binding|,9,2.1,1.43,10,-3.3,4.15,-2.5,2.4,0.237,-7.3,5.3
ENSMUSG00000027794,SOHLH2,spermatogenesis and oogenesis specific basic helix-loop-helix 2,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|spermatogenesis|oogenesis|",DNA binding|protein dimerization activity|,0,0,0,1,-3.1,2.53,-3.1,2.39,0.238,-6,1
ENSMUSG00000002324,REC8,REC8 meiotic recombination protein,condensed nuclear chromosome kinetochore|lateral element|male germ cell nucleus|nucleus|nuclear meiotic cohesin complex|,double-strand break repair via homologous recombination|oocyte maturation|sister chromatid cohesion|meiotic nuclear division|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|fertilization|linear element assembly|seminiferous tubule development|,None,10,-2.2,2.83,10,2.6,1.18,-2.4,2.39,0.238,-6.7,8.9
ENSMUSG00000041287,SOX15,SRY (sex determining region Y)-box 15,nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|male gonad development|positive regulation of satellite cell activation involved in skeletal muscle regeneration|cell differentiation|skeletal muscle tissue regeneration|negative regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|myoblast development|positive regulation of G0 to G1 transition|positive regulation of myoblast proliferation|",DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|,1,1.6,0.864,1,-3.4,2.99,-3.3,2.39,0.238,-6,3
ENSMUSG00000026500,COX20,COX20 cytochrome C oxidase assembly factor,mitochondrion|integral component of membrane|mitochondrial membrane|,None,None,0,0,0,3,2.2,2.52,2.2,2.39,0.238,-1.1,5
ENSMUSG00000024902,MRPL11,mitochondrial ribosomal protein L11,mitochondrial ribosome|,translation|,structural constituent of ribosome|protein binding|poly(A) RNA binding|,0,0,0,2,2.7,2.53,2.7,2.39,0.238,-1,6
ENSMUSG00000021098,4930447C04RIK,RIKEN cDNA 4930447C04 gene,cellular_component|,multicellular organismal development|regulation of sequence-specific DNA binding transcription factor activity|,molecular_function|,0,0,0,1,-3.1,2.52,-3.1,2.39,0.238,-6,1
ENSMUSG00000052062,PARD3B,par-3 family cell polarity regulator beta,tight junction|endomembrane system|membrane|,cell cycle|cell division|,None,10,-3.5,3.12,10,-0.8,0.73,-1.3,2.39,0.238,-8.5,2
ENSMUSG00000003402,PRKCSH,protein kinase C substrate 80K-H,intracellular|endoplasmic reticulum|endoplasmic reticulum lumen|,in utero embryonic development|liver development|protein folding|N-glycan processing|nitrogen compound metabolic process|negative regulation of neuron projection development|protein N-linked glycosylation via asparagine|intracellular signal transduction|post-translational protein modification|cellular protein metabolic process|innate immune response|protein heterooligomerization|renal system development|,RNA binding|protein kinase C binding|calcium ion binding|ion channel binding|phosphoprotein binding|,10,-1.1,0.936,10,-1.5,1.68,-1.3,2.39,0.238,-5.8,3.8
ENSMUSG00000030208,EMP1,epithelial membrane protein 1,plasma membrane|membrane|integral component of membrane|,multicellular organismal development|cell proliferation|epidermis development|cell growth|,None,9,-1.5,0.529,10,-1.3,2.03,-1.4,2.38,0.239,-5.1,1.2
ENSMUSG00000006423,C330007P06RIK,RIKEN cDNA C330007P06 gene,cellular_component|,biological_process|,molecular_function|,1,-4.6,2.51,0,0,0,-4.6,2.38,0.239,-9,0.8
ENSMUSG00000050812,AI314180,expressed sequence AI314180,proteasome complex|nucleus|cytoplasm|endosome|early endosome|late endosome|multivesicular body|endoplasmic reticulum|centrosome|cytoskeleton|membrane|cytoplasmic membrane-bounded vesicle|ER to Golgi transport vesicle|endocytic vesicle|cytoplasmic vesicle|,ER-associated ubiquitin-dependent protein catabolic process|,None,8,1.7,1.36,9,1.5,1.22,1.6,2.38,0.239,-4.8,5.1
ENSMUSG00000026698,PIGC,"phosphatidylinositol glycan anchor biosynthesis, class C",glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|integral component of membrane|,C-terminal protein lipidation|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,catalytic activity|phosphatidylinositol N-acetylglucosaminyltransferase activity|,10,3.2,0.0397,10,2,2.64,2.1,2.37,0.24,-3.1,6.2
ENSMUSG00000066306,NUMA1,nuclear mitotic apparatus protein 1,Golgi membrane|spindle pole|nucleus|nucleoplasm|chromosome|cytoplasm|spindle|cytosol|spindle microtubule|nuclear matrix|dendrite|neuronal cell body|apical part of cell|,G2/M transition of mitotic cell cycle|mitotic anaphase|establishment of mitotic spindle orientation|mitotic cell cycle|nucleus organization|mitotic nuclear division|meiotic cell cycle|lung epithelial cell differentiation|,structural molecule activity|protein binding|microtubule binding|,9,-2.1,0.495,10,-1.6,2.21,-1.8,2.37,0.24,-5.3,2.5
ENSMUSG00000026361,CDC73,cell division cycle 73,nucleus|Cdc73/Paf1 complex|,"negative regulation of transcription from RNA polymerase II promoter|endodermal cell fate commitment|transcription, DNA-templated|mRNA polyadenylation|cell cycle|negative regulation of cell proliferation|histone monoubiquitination|Wnt signaling pathway|stem cell maintenance|positive regulation of Wnt signaling pathway|positive regulation of mRNA 3'-end processing|protein destabilization|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation|cellular response to lipopolysaccharide|negative regulation of G1/S transition of mitotic cell cycle|",RNA polymerase II core binding|protein binding|,8,3.3,5.38,10,-2.7,3.4,3.2,2.37,0.24,-5.5,7.4
ENSMUSG00000021210,AKR1C6,"aldo-keto reductase family 1, member C6",nucleus|cytoplasm|,lipid metabolic process|steroid biosynthetic process|steroid metabolic process|response to drug|response to estrogen|daunorubicin metabolic process|doxorubicin metabolic process|oxidation-reduction process|cellular response to jasmonic acid stimulus|,"C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|retinal dehydrogenase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase activity|isocitrate dehydrogenase activity|mevaldate reductase activity|gluconate dehydrogenase activity|steroid dehydrogenase activity|oxidoreductase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|epoxide dehydrogenase activity|5-exo-hydroxycamphor dehydrogenase activity|2-hydroxytetrahydrofuran dehydrogenase activity|acetoin dehydrogenase activity|phenylcoumaran benzylic ether reductase activity|D-xylose:NADP reductase activity|L-arabinose:NADP reductase activity|D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity|steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|steroid dehydrogenase activity, acting on the CH-CH group of donors|(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity|3-hydroxymenthone dehydrogenase activity|very long-chain-3-hydroxyacyl-CoA dehydrogenase activity|dihydrotestosterone 17-beta-dehydrogenase activity|(R)-2-hydroxyisocaproate dehydrogenase activity|L-arabinose 1-dehydrogenase (NADP+) activity|L-xylulose reductase (NAD+) activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|androsterone dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|3-ketoglucose-reductase activity|(R)-2-hydroxyglutarate dehydrogenase activity|D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity|",10,-0.8,0.232,10,-1.6,2.4,-1.7,2.36,0.241,-7,3.7
ENSMUSG00000023915,TNFRSF21,"tumor necrosis factor receptor superfamily, member 21",plasma membrane|integral component of plasma membrane|axon|intrinsic component of plasma membrane|,B cell apoptotic process|adaptive immune response|apoptotic process|humoral immune response|negative regulation of B cell proliferation|negative regulation of myelination|negative regulation of T cell proliferation|myelination|cellular lipid metabolic process|small molecule metabolic process|regulation of oligodendrocyte differentiation|T cell receptor signaling pathway|neuron apoptotic process|cellular response to tumor necrosis factor|oligodendrocyte apoptotic process|negative regulation of interleukin-5 secretion|negative regulation of interleukin-13 secretion|negative regulation of interleukin-10 secretion|,protein binding|,10,-1.7,3.48,10,-0.2,0.0333,-1.4,2.36,0.241,-6.6,1.3
ENSMUSG00000036223,SKA1,spindle and kinetochore associated complex subunit 1,condensed chromosome outer kinetochore|cytosol|spindle microtubule|microtubule cytoskeleton|,mitotic cell cycle|chromosome segregation|mitotic nuclear division|regulation of microtubule polymerization or depolymerization|cell division|,protein binding|microtubule binding|,6,-1.7,0.952,8,3.3,3.27,-2.9,2.35,0.242,-7.3,6.1
ENSMUSG00000030265,KRAS,Kirsten rat sarcoma viral oncogene homolog,mitochondrion|plasma membrane|membrane|membrane raft|,"MAPK cascade|activation of MAPKK activity|positive regulation of protein phosphorylation|GTP catabolic process|epidermal growth factor receptor signaling pathway|small GTPase mediated signal transduction|Ras protein signal transduction|axon guidance|blood coagulation|positive regulation of cell proliferation|insulin receptor signaling pathway|visual learning|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|cytokine-mediated signaling pathway|actin cytoskeleton organization|regulation of synaptic transmission, GABAergic|positive regulation of Rac protein signal transduction|social behavior|Fc-epsilon receptor signaling pathway|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|innate immune response|neurotrophin TRK receptor signaling pathway|regulation of long-term neuronal synaptic plasticity|leukocyte migration|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|striated muscle cell differentiation|response to glucocorticoid|response to mineralocorticoid|",protein binding|GTP binding|GMP binding|GDP binding|LRR domain binding|protein complex binding|,10,-0.8,0.943,10,-2.5,2.2,-1.4,2.35,0.242,-5.6,2.3
ENSMUSG00000072722,GM6588,predicted gene 6588,cellular_component|,biological_process|,molecular_function|,0,0,0,1,2.9,2.47,2.9,2.34,0.243,-1.1,6
ENSMUSG00000026276,2-Sep,septin 2,exocyst|condensed chromosome kinetochore|nucleus|nucleolus|cytoplasm|spindle|cell cortex|actin cytoskeleton|midbody|septin complex|cleavage furrow|synapse|perinuclear region of cytoplasm|ciliary membrane|extracellular vesicular exosome|,regulation of L-glutamate transport|mitotic nuclear division|smoothened signaling pathway|neuron projection development|regulation of protein localization|cilium assembly|regulation of catalytic activity|,protein binding|GTP binding|enzyme regulator activity|protein complex scaffold|,10,2.1,3.27,9,0.2,0.0241,2.1,2.34,0.243,-8.7,6
ENSMUSG00000021508,CXCL14,chemokine (C-X-C motif) ligand 14,extracellular space|Golgi apparatus|,chemotaxis|immune response|signal transduction|cell-cell signaling|inner ear development|cell chemotaxis|cell chemotaxis|,chemokine activity|,10,-1.1,1.35,10,-1.2,1.17,-1.2,2.34,0.243,-4.6,2.3
ENSMUSG00000021939,CTSB,cathepsin B,extracellular region|extracellular space|extracellular space|intracellular|nucleolus|mitochondrion|lysosome|endolysosome lumen|melanosome|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|extracellular vesicular exosome|,toll-like receptor signaling pathway|proteolysis|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|collagen catabolic process|epithelial cell differentiation|regulation of apoptotic process|innate immune response|regulation of catalytic activity|proteolysis involved in cellular protein catabolic process|cellular response to thyroid hormone stimulus|,cysteine-type endopeptidase activity|protein binding|collagen binding|peptidase activity|cysteine-type peptidase activity|proteoglycan binding|,10,3.4,2.04,10,-1.1,2.38,-1.1,2.34,0.243,-9.9,5.6
ENSMUSG00000020228,HELB,helicase (DNA) B,alpha DNA polymerase:primase complex|,"DNA replication|DNA replication, synthesis of RNA primer|DNA duplex unwinding|DNA duplex unwinding|",ATP binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|ATP-dependent 5'-3' DNA helicase activity|,0,0,0,1,-3.1,2.47,-3.1,2.34,0.243,-6,1.1
ENSMUSG00000024182,AXIN1,axin 1,nucleus|cytoplasm|Golgi apparatus|cytosol|cytoplasmic microtubule|cell cortex|postsynaptic density|cytoplasmic membrane-bounded vesicle|lateral plasma membrane|beta-catenin destruction complex|cytoplasmic vesicle|perinuclear region of cytoplasm|cell periphery|,"protein polyubiquitination|in utero embryonic development|optic placode formation|positive regulation of protein phosphorylation|nucleocytoplasmic transport|apoptotic process|activation of JUN kinase activity|determination of left/right symmetry|sensory perception of sound|cell death|dorsal/ventral axis specification|positive regulation of peptidyl-threonine phosphorylation|forebrain anterior/posterior pattern specification|Wnt-activated signaling pathway involved in forebrain neuron fate commitment|protein catabolic process|negative regulation of Wnt signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|olfactory placode formation|cytoplasmic microtubule organization|positive regulation of protein ubiquitination|activation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of transcription elongation from RNA polymerase II promoter|regulation of catenin import into nucleus|post-anal tail morphogenesis|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|cellular protein complex assembly|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|positive regulation of protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|embryonic eye morphogenesis|axial mesoderm formation|negative regulation of protein metabolic process|protein homooligomerization|positive regulation of ubiquitin-protein transferase activity|muscle cell development|canonical Wnt signaling pathway|embryonic skeletal joint morphogenesis|canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation|cellular response to organic cyclic compound|genetic imprinting|negative regulation of canonical Wnt signaling pathway|Wnt signaling pathway involved in somitogenesis|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|",signal transducer activity|GTPase activator activity|receptor binding|protein binding|beta-catenin binding|protein C-terminus binding|enzyme binding|protein kinase binding|protein kinase binding|ubiquitin protein ligase binding|protein complex scaffold|protein complex scaffold|identical protein binding|protein homodimerization activity|protein self-association|SMAD binding|armadillo repeat domain binding|armadillo repeat domain binding|I-SMAD binding|R-SMAD binding|,9,0,0,9,-3,4.41,-2.8,2.33,0.244,-8.5,1.4
ENSMUSG00000032744,HEYL,hes-related family bHLH transcription factor with YRPW motif-like,nucleus|nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|atrioventricular valve morphogenesis|pulmonary valve morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|Notch signaling pathway|Notch signaling pathway|mesenchymal cell development|glomerulus development|skeletal muscle cell differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cardiac epithelial to mesenchymal transition|ventricular septum morphogenesis|negative regulation of androgen receptor signaling pathway|cellular response to BMP stimulus|proximal tubule development|negative regulation of androgen receptor activity|",RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|protein binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|transcription factor binding|microsatellite binding|protein homodimerization activity|protein heterodimerization activity|AF-1 domain binding|,10,1.8,2.38,10,0.5,0.183,1.7,2.32,0.245,-3.7,5.7
ENSMUSG00000028426,RAD23B,RAD23 homolog B (S. cerevisiae),proteasome complex|nucleus|nucleoplasm|cytoplasm|XPC complex|,"nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|DNA repair|nucleotide-excision repair|nucleotide-excision repair|spermatogenesis|regulation of proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|",damaged DNA binding|single-stranded DNA binding|protein binding|polyubiquitin binding|,10,-2.2,1.49,9,-1.2,1.41,-2,2.32,0.245,-4.5,0.7
ENSMUSG00000041777,CIR1,"corepressor interacting with RBPJ, 1",histone deacetylase complex|nucleus|cytoplasm|microtubule organizing center|nuclear speck|,"regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|mRNA processing|RNA splicing|negative regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|,2,3.2,2.95,1,-2.5,1.13,3.1,2.32,0.245,-6.2,7
ENSMUSG00000068566,MYADM,myeloid-associated differentiation marker,ruffle|plasma membrane|plasma membrane|cell-cell junction|integral component of membrane|cortical actin cytoskeleton|membrane raft|extracellular vesicular exosome|,negative regulation of protein phosphorylation|negative regulation of gene expression|positive regulation of cell migration|negative regulation of actin filament polymerization|membrane raft organization|negative regulation of heterotypic cell-cell adhesion|establishment of endothelial barrier|protein targeting to plasma membrane|negative regulation of protein kinase C signaling|positive regulation of substrate adhesion-dependent cell spreading|,molecular_function|,1,2.8,2.91,1,-1.9,0.535,2.7,2.32,0.245,-2.2,6
ENSMUSG00000060843,CTNNA3,"catenin (cadherin-associated protein), alpha 3",cytoplasm|fascia adherens|actin cytoskeleton|lamellipodium|,single organismal cell-cell adhesion|,structural molecule activity|protein binding|cadherin binding|,8,-4.1,2.55,8,-1.7,0.533,-3.9,2.32,0.245,-8.4,4.8
ENSMUSG00000048982,GPHB5,glycoprotein hormone beta 5,extracellular region|,None,hormone activity|,1,2.8,2.89,1,-3.1,2.47,2.7,2.3,0.248,-5.3,6
ENSMUSG00000020334,SLC22A4,"solute carrier family 22 (organic cation/zwitterion transporter), member 4",mitochondrion|plasma membrane|plasma membrane|integral component of plasma membrane|apical plasma membrane|,triglyceride metabolic process|sodium ion transport|body fluid secretion|carnitine metabolic process|organic cation transport|quaternary ammonium group transport|carnitine transport|transmembrane transport|carnitine transmembrane transport|carnitine transmembrane transport|,nucleotide binding|protein binding|ATP binding|secondary active organic cation transmembrane transporter activity|carnitine transmembrane transporter activity|symporter activity|cation:cation antiporter activity|quaternary ammonium group transmembrane transporter activity|PDZ domain binding|,0,0,0,1,2.9,2.43,2.9,2.3,0.248,-1.1,6
ENSMUSG00000024097,SRSF7,serine/arginine-rich splicing factor 7,nucleus|nucleoplasm|cytoplasm|extracellular vesicular exosome|,"mRNA splicing, via spliceosome|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|mRNA processing|mRNA export from nucleus|RNA splicing|gene expression|mRNA 3'-end processing|negative regulation of mRNA splicing, via spliceosome|",nucleotide binding|protein binding|zinc ion binding|poly(A) RNA binding|,1,-4.4,2.43,0,0,0,-4.4,2.3,0.248,-9,0.8
ENSMUSG00000095264,GM2854,predicted gene 2854,None,None,None,1,2.1,1.53,3,-3.9,2.94,-3.8,2.3,0.248,-8,3.6
ENSMUSG00000039457,PPL,periplakin,nucleus|mitochondrion|cytoskeleton|plasma membrane|desmosome|extracellular vesicular exosome|,keratinization|,structural constituent of cytoskeleton|protein binding|,0,0,0,1,2.9,2.43,2.9,2.3,0.248,-1.1,6
ENSMUSG00000070306,CCDC153,coiled-coil domain containing 153,None,None,None,0,0,0,1,2.9,2.43,2.9,2.3,0.248,-1.1,6
ENSMUSG00000012609,TTLL5,"tubulin tyrosine ligase-like family, member 5",nucleus|cytoplasm|centrosome|cilium|,"transcription, DNA-templated|cellular protein modification process|",ligase activity|,10,-2.2,1.62,10,-1.2,1.25,-1.9,2.3,0.248,-4.9,4.2
ENSMUSG00000048482,BDNF,brain-derived neurotrophic factor,extracellular region|cytoplasm|synaptic vesicle|perinuclear region of cytoplasm|,"ureteric bud development|behavioral fear response|response to hypoxia|chronic inflammatory response|mitochondrial electron transport, NADH to ubiquinone|nervous system development|negative regulation of neuroblast proliferation|axon guidance|axon target recognition|learning or memory|feeding behavior|neuron recognition|response to hormone|glutamate secretion|response to fluoxetine|dendrite development|regulation of metabolic process|nerve development|response to vitamin A|mechanoreceptor differentiation|negative regulation of neuron apoptotic process|positive regulation of neuron differentiation|negative regulation of striated muscle tissue development|regulation of retinal cell programmed cell death|positive regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|inner ear development|positive regulation of synapse assembly|response to hyperoxia|regulation of excitatory postsynaptic membrane potential|response to anesthetic|",neurotrophin TRKB receptor binding|growth factor activity|,10,-6.1,0.743,10,-1.5,2.78,-1.4,2.3,0.248,-10.4,2.7
ENSMUSG00000042659,ARRDC4,arrestin domain containing 4,endosome|plasma membrane|,positive regulation of ubiquitin-protein transferase activity|,None,10,-0.9,0.464,10,-2.5,2.84,-2.2,2.29,0.249,-7.4,7.5
ENSMUSG00000040265,DNM3,dynamin 3,mitochondrion|microtubule|postsynaptic density|dendritic spine|perinuclear region of cytoplasm|,GTP catabolic process|GTP catabolic process|endocytosis|synapse assembly|filopodium assembly|,GTPase activity|protein binding|GTP binding|,10,2.1,4.03,10,-1.2,1.82,1.6,2.29,0.249,-6.9,5.5
ENSMUSG00000027332,IVD,isovaleryl-CoA dehydrogenase,mitochondrial matrix|mitochondrial matrix|,leucine catabolic process|leucine catabolic process|branched-chain amino acid catabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|oxidation-reduction process|,isovaleryl-CoA dehydrogenase activity|isovaleryl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|,10,-3,1.44,10,-1.4,1.55,-2.6,2.28,0.25,-8.5,1.8
ENSMUSG00000094686,CCL21A,chemokine (C-C motif) ligand 21A (serine),None,lymph node development|induction of positive chemotaxis|cell chemotaxis|positive regulation of T cell migration|,chemokine activity|chemokine receptor binding|,10,-2.7,3.1,10,-0.7,0.455,-2.1,2.28,0.25,-7,5.2
ENSMUSG00000023953,POLH,"polymerase (DNA directed), eta",nucleoplasm|,DNA synthesis involved in DNA repair|DNA-dependent DNA replication|DNA-dependent DNA replication|DNA repair|regulation of DNA repair|pyrimidine dimer repair|postreplication repair|response to UV-C|,damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|metal ion binding|,10,-2.9,2.83,10,2.2,3.62,-2.7,2.28,0.25,-5.4,4.5
ENSMUSG00000025006,SORBS1,sorbin and SH3 domain containing 1,stress fiber|nucleus|cytosol|cytosol|insulin receptor complex|cell-cell adherens junction|zonula adherens|cell-substrate adherens junction|focal adhesion|nuclear matrix|membrane raft|,muscle contraction|cell-matrix adhesion|insulin receptor signaling pathway|positive regulation of signal transduction|positive regulation of signal transduction|glucose transport|cellular response to insulin stimulus|stress fiber assembly|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of lipid biosynthetic process|focal adhesion assembly|positive regulation of establishment of protein localization to plasma membrane|,actin binding|SH3/SH2 adaptor activity|SH3/SH2 adaptor activity|insulin receptor binding|protein binding|cytoskeletal protein binding|protein kinase binding|,2,-4.6,1.82,1,-2.4,1.03,-4.5,2.28,0.25,-9,3.7
ENSMUSG00000033444,SPECC1L,sperm antigen with calponin homology and coiled-coil domains 1-like,cytoplasm|spindle|gap junction|,cell cycle|cell division|,None,10,0,0,10,-4.4,3.11,-1.1,2.28,0.25,-10.6,1.9
ENSMUSG00000032965,IFT57,intraflagellar transport 57,Golgi apparatus|photoreceptor connecting cilium|ciliary basal body|dendrite terminus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of apoptotic process|",DNA binding|protein binding|,10,1,0.347,10,2.8,2.64,2.3,2.27,0.251,-9.2,5.2
ENSMUSG00000031201,BRCC3,"BRCA1/BRCA2-containing complex, subunit 3",ubiquitin ligase complex|nuclear ubiquitin ligase complex|nucleus|BRCA1-A complex|BRISC complex|,double-strand break repair|proteolysis|response to X-ray|response to ionizing radiation|G2 DNA damage checkpoint|positive regulation of DNA repair|regulation of catalytic activity|protein K63-linked deubiquitination|histone H2A K63-linked deubiquitination|histone H2A K63-linked deubiquitination|,ubiquitin thiolesterase activity|ubiquitin-specific protease activity|protein binding|metallopeptidase activity|enzyme regulator activity|polyubiquitin binding|metal ion binding|,10,0.7,0.338,10,1.4,2.43,1,2.27,0.251,-2.7,5
ENSMUSG00000043050,TNP2,transition protein 2 (during histone to protamine replacement),nucleosome|nucleus|,multicellular organismal development|spermatogenesis|binding of sperm to zona pellucida|acrosome reaction|penetration of zona pellucida|cell differentiation|sperm motility|,DNA binding|metal ion binding|,10,-2.1,2.78,9,1.3,0.922,-2,2.27,0.251,-6.4,3.8
ENSMUSG00000035007,RUNDC1,RUN domain containing 1,None,None,None,0,0,0,1,-3.1,2.4,-3.1,2.27,0.251,-6,1.1
ENSMUSG00000021125,ARG2,arginase 2,mitochondrion|mitochondrial matrix|,urea cycle|urea cycle|ureteric bud development|arginine metabolic process|nitric oxide biosynthetic process|striated muscle contraction|cellular nitrogen compound metabolic process|small molecule metabolic process|,arginase activity|metal ion binding|,10,0,0,10,-2,3.24,-1.9,2.27,0.251,-6.1,2
ENSMUSG00000051306,USP42,ubiquitin specific peptidase 42,None,ubiquitin-dependent protein catabolic process|spermatogenesis|protein deubiquitination|protein deubiquitination|cell differentiation|,ubiquitin-specific protease activity|protein binding|,10,4.2,0.0124,10,-2,3.18,-1.8,2.26,0.252,-7.2,6.1
ENSMUSG00000050192,EIF5A2,eukaryotic translation initiation factor 5A2,nuclear pore|endoplasmic reticulum membrane|cytosol|,translational frameshifting|spermatogenesis|positive regulation of cell proliferation|peptidyl-lysine modification to peptidyl-hypusine|polyamine homeostasis|protein transport|post-translational protein modification|cellular protein metabolic process|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport|,translation elongation factor activity|protein binding|ribosome binding|,0,0,0,1,2.9,2.39,2.9,2.26,0.252,-1.1,6
ENSMUSG00000041358,NUTM1,"NUT midline carcinoma, family member 1",nucleus|cytoplasm|,None,None,10,1.1,0.644,10,-2.2,2.61,-1.4,2.26,0.252,-6.2,3.1
ENSMUSG00000035493,TGFBI,"transforming growth factor, beta-induced, 68kDa",extracellular region|basement membrane|extracellular space|trans-Golgi network|plasma membrane|extracellular matrix|extracellular matrix|extracellular vesicular exosome|,angiogenesis|chondrocyte differentiation|cell adhesion|negative regulation of cell adhesion|visual perception|cell proliferation|extracellular matrix organization|response to stimulus|,integrin binding|protein binding|collagen binding|extracellular matrix binding|,10,-2.7,3.6,10,-0.6,0.0802,-2.4,2.25,0.254,-7.2,1.1
ENSMUSG00000031431,TSC22D3,"TSC22 domain family, member 3",nucleus|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-templated|response to osmotic stress|body fluid secretion|ion transmembrane transport|negative regulation of skeletal muscle tissue development|transmembrane transport|negative regulation of activation-induced cell death of T cells|",sequence-specific DNA binding transcription factor activity|MRF binding|,10,2,3.13,9,-1.5,0.495,1.6,2.25,0.254,-4.4,5.7
ENSMUSG00000037742,EEF1A1,eukaryotic translation elongation factor 1 alpha 1,extracellular space|nucleus|nucleolus|cytoplasm|cytoplasm|cytoplasm|cytosol|eukaryotic translation elongation factor 1 complex|plasma membrane|membrane|extracellular vesicular exosome|,"GTP catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|translation|translational elongation|gene expression|cellular protein metabolic process|cellular response to epidermal growth factor stimulus|",translation elongation factor activity|GTPase activity|protein binding|GTP binding|protein kinase binding|poly(A) RNA binding|,5,2.3,2.89,4,-2.5,1.98,-2.1,2.25,0.254,-7.2,4.9
ENSMUSG00000021214,AKR1C18,"aldo-keto reductase family 1, member C18",intracellular|nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,"protein import into nucleus, translocation|progesterone catabolic process|progesterone catabolic process|G-protein coupled receptor signaling pathway|parturition|positive regulation of cell proliferation|positive regulation of cell death|farnesol catabolic process|cellular response to reactive oxygen species|response to prostaglandin|progesterone metabolic process|retinal metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|regulation of retinoic acid receptor signaling pathway|regulation of steroid biosynthetic process|positive regulation of protein kinase B signaling|oxidation-reduction process|oxidation-reduction process|testosterone biosynthetic process|cellular response to cadmium ion|cellular response to calcium ion|cellular response to prostaglandin stimulus|cellular response to corticosteroid stimulus|cellular response to jasmonic acid stimulus|negative regulation of retinoic acid biosynthetic process|regulation of testosterone biosynthetic process|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process|","retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|retinol dehydrogenase activity|prostaglandin F receptor activity|oxidoreductase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|pinocarveol dehydrogenase activity|chloral hydrate dehydrogenase activity|hydroxymethylmethylsilanediol oxidase activity|1-phenylethanol dehydrogenase activity|myrtenol dehydrogenase activity|phenanthrene 9,10-monooxygenase activity|cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity|3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity|2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity|cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity|citronellol dehydrogenase activity|naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity|2,4,4-trimethyl-1-pentanol dehydrogenase activity|2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity|1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity|endosulfan diol dehydrogenase activity|endosulfan hydroxyether dehydrogenase activity|3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity|3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity|dihydrotestosterone 17-beta-dehydrogenase activity|versicolorin reductase activity|geranylgeranyl reductase activity|ketoreductase activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|androsterone dehydrogenase activity|ketosteroid monooxygenase activity|delta4-3-oxosteroid 5beta-reductase activity|",10,-4,2.66,10,0,0,-1.9,2.25,0.254,-7.6,1.4
ENSMUSG00000026173,PLCD4,"phospholipase C, delta 4",nucleus|endoplasmic reticulum|membrane|,acrosome reaction|lipid catabolic process|intracellular signal transduction|phosphatidylinositol metabolic process|,phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|,1,0.6,0.145,1,-3.3,2.84,-3.2,2.25,0.254,-6,1.1
ENSMUSG00000094918,GM8765,predicted gene 8765,cellular_component|,biological_process|,molecular_function|,1,-4.3,2.37,0,0,0,-4.3,2.24,0.255,-8,0.9
ENSMUSG00000028693,NASP,nuclear autoantigenic sperm protein (histone-binding),nuclear chromatin|nucleus|nucleus|cytoplasm|protein complex|,blastocyst development|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|cell cycle|cell proliferation|protein transport|histone exchange|,histone binding|Hsp90 protein binding|,9,-0.6,0.171,10,-3,3.02,-1.1,2.24,0.255,-9.5,2
ENSMUSG00000021114,ATP6V1D,"ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D",lysosomal membrane|centrosome|cytosol|cilium|membrane|vacuolar proton-transporting V-type ATPase complex|extracellular vesicular exosome|,cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport|cilium assembly|interaction with host|transmembrane transport|protein localization to cilium|phagosome maturation|,"protein binding|ATPase activity, coupled to transmembrane movement of substances|",9,-2.8,2.05,10,-1.9,0.596,-2.6,2.24,0.255,-8,4.7
ENSMUSG00000051851,CXX1C,CAAX box 1C,cellular_component|,biological_process|,molecular_function|,1,-2,0.74,1,3.1,2.81,3,2.24,0.255,-3.1,6
ENSMUSG00000026700,TNFSF4,"tumor necrosis factor (ligand) superfamily, member 4",extracellular space|integral component of plasma membrane|cell surface|,"defense response to nematode|acute inflammatory response|positive regulation of T cell cytokine production|regulation of adaptive immune response|positive regulation of type 2 immune response|positive regulation of immunoglobulin mediated immune response|immune response|signal transduction|cholesterol metabolic process|positive regulation of cell proliferation|response to virus|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-2 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|memory T cell activation|T-helper 2 cell activation|response to nitrogen dioxide|cellular response to nitrogen dioxide|CD4-positive, alpha-beta T cell costimulation|T cell proliferation|positive regulation of activated T cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of memory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of regulatory T cell differentiation|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell proliferation|negative regulation of cytokine secretion|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of B cell activation|positive regulation of immunoglobulin secretion|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|positive regulation of CD4-positive, alpha-beta T cell costimulation|positive regulation of memory T cell activation|positive regulation of T-helper 2 cell activation|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes|",receptor binding|cytokine activity|tumor necrosis factor receptor binding|tumor necrosis factor receptor superfamily binding|,10,-2,2.38,10,-0.9,0.311,-1.7,2.24,0.255,-5.5,3.4
ENSMUSG00000026922,AGPAT2,1-acylglycerol-3-phosphate O-acyltransferase 2,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|phospholipid metabolic process|phospholipid metabolic process|phosphatidic acid biosynthetic process|phosphatidic acid biosynthetic process|epidermis development|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|glycerophospholipid biosynthetic process|,1-acylglycerol-3-phosphate O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity|,10,1.9,3.71,10,-0.9,0.524,1.7,2.23,0.256,-4.6,4.7
ENSMUSG00000095854,TRAV14D-1,T-cell receptor alpha variable region 14D-1,None,None,None,1,-4.3,2.36,0,0,0,-4.3,2.23,0.256,-8,0.9
ENSMUSG00000044701,IL27,interleukin 27,extracellular space|,inflammatory response|response to bacterium|regulation of T cell proliferation|positive regulation of interferon-gamma biosynthetic process|innate immune response|regulation of T-helper 1 cell differentiation|regulation of defense response to virus|,receptor binding|cytokine activity|interleukin-27 receptor binding|,1,-4.3,2.36,0,0,0,-4.3,2.23,0.256,-8,0.9
ENSMUSG00000025134,ALYREF,Aly/REF export factor,transcription export complex|nucleoplasm|cytosol|membrane|nuclear speck|exon-exon junction complex|extracellular vesicular exosome|catalytic step 2 spliceosome|,"regulation of DNA recombination|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|osteoblast differentiation|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|mRNA export from nucleus|mRNA export from nucleus|RNA splicing|gene expression|mRNA 3'-end processing|replication fork processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|",nucleotide binding|protein binding|poly(A) RNA binding|,10,1.2,1.12,9,1.5,1.33,1.3,2.23,0.256,-4,5.9
ENSMUSG00000029364,WSB2,WD repeat and SOCS box containing 2,None,protein ubiquitination|intracellular signal transduction|,None,0,0,0,1,-3,2.36,-3,2.23,0.256,-6,1.1
ENSMUSG00000033377,PALMD,palmdelphin,cytoplasm|membrane|dendritic spine|,regulation of cell shape|,None,0,0,0,1,2.9,2.36,2.9,2.23,0.256,-1.1,6
ENSMUSG00000030986,DHX32,DEAH (Asp-Glu-Ala-His) box polypeptide 32,nucleus|mitochondrion|,metabolic process|,helicase activity|ATP binding|,0,0,0,1,2.9,2.36,2.9,2.23,0.256,-1.1,6
ENSMUSG00000032397,TIPIN,TIMELESS interacting protein,nuclear chromatin|nucleus|cytoplasm|Golgi apparatus|intracellular membrane-bounded organelle|,DNA replication checkpoint|mitotic nuclear division|positive regulation of cell proliferation|response to UV|intra-S DNA damage checkpoint|regulation of nuclear cell cycle DNA replication|cell cycle phase transition|replication fork protection|,protein binding|,8,-2.6,1.92,7,3.5,1.19,-2.1,2.23,0.256,-6.7,5
ENSMUSG00000016559,H3F3B,"H3 histone, family 3B (H3.3B)",nuclear chromosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|protein complex|extracellular vesicular exosome|,DNA replication-independent nucleosome assembly|brain development|blood coagulation|response to hormone|positive regulation of cell growth|,RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|protein binding|nucleosomal DNA binding|protein heterodimerization activity|,10,-2.8,0.214,10,-3.4,2.29,-3.1,2.22,0.258,-7.7,0.9
ENSMUSG00000030983,BCCIP,BRCA2 and CDKN1A interacting protein,nucleus|nuclear cyclin-dependent protein kinase holoenzyme complex|,regulation of cyclin-dependent protein serine/threonine kinase activity|DNA repair|cell cycle|neuroendocrine cell differentiation|,protein binding|kinase regulator activity|poly(A) RNA binding|,7,3.5,4.17,5,-1.9,0.979,2.9,2.22,0.258,-4.4,7.7
ENSMUSG00000020799,TEKT1,tektin 1,nucleus|cytoplasm|microtubule|cilium|,microtubule cytoskeleton organization|,None,10,-2.1,1.19,10,-1.8,1.24,-2,2.22,0.258,-7,3.5
ENSMUSG00000056536,PIGN,"phosphatidylinositol glycan anchor biosynthesis, class N",endoplasmic reticulum membrane|membrane|integral component of membrane|,C-terminal protein lipidation|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,transferase activity|,9,-0.8,0.483,9,-1.6,2.2,-1.3,2.22,0.258,-5.8,3.2
ENSMUSG00000051728,4930563D23RIK,RIKEN cDNA 4930563D23 gene,cellular_component|,biological_process|,molecular_function|,1,-4.2,2.35,1,-1.7,0.399,-4.1,2.21,0.259,-8,0.8
ENSMUSG00000045287,RTN4RL1,reticulon 4 receptor-like 1,external side of plasma membrane|cell surface|membrane raft|anchored component of plasma membrane|,axon regeneration|,receptor activity|,1,-4.2,2.34,0,0,0,-4.2,2.21,0.259,-8,0.9
ENSMUSG00000019564,ARID3A,AT rich interactive domain 3A (BRIGHT-like),nucleus|nucleolus|cytoplasm|Golgi apparatus|membrane raft|,"transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|protein homodimerization activity|,1,-4.2,2.34,0,0,0,-4.2,2.21,0.259,-8,0.9
ENSMUSG00000080268,BRMS1,breast cancer metastasis suppressor 1,nucleus|cytoplasm|,"transcription, DNA-templated|apoptotic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-templated|positive regulation of protein deacetylation|positive regulation of anoikis|",protein binding|NF-kappaB binding|,10,-1.4,1.87,10,-0.9,0.696,-1.2,2.21,0.259,-6.1,2.4
ENSMUSG00000060204,GM5868,predicted gene 5868,cellular_component|,biological_process|,molecular_function|,1,2.5,2.34,0,0,0,2.5,2.21,0.259,-1.1,6
ENSMUSG00000031425,PLP1,proteolipid protein 1,plasma membrane|integral component of membrane|myelin sheath|,integrin-mediated signaling pathway|synaptic transmission|cell death|axon ensheathment|positive regulation of gene expression|substantia nigra development|central nervous system myelination|long-chain fatty acid biosynthetic process|cell maturation|,structural molecule activity|structural constituent of myelin sheath|,10,7.7,4.81,10,0.8,0.445,7.5,2.21,0.259,-0.1,16
ENSMUSG00000028519,DAB1,"Dab, reelin signal transducer, homolog 1 (Drosophila)",cytosol|brush border|postsynaptic density|membrane|neuron projection|neuronal cell body|apical part of cell|perinuclear region of cytoplasm|,negative regulation of cell adhesion|small GTPase mediated signal transduction|midgut development|adult walking behavior|dendrite development|ventral spinal cord development|cerebellum structural organization|cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration|radial glia guided migration of Purkinje cell|response to drug|positive regulation of neuron differentiation|positive regulation of protein kinase activity|negative regulation of JAK-STAT cascade|negative regulation of astrocyte differentiation|negative regulation of axonogenesis|Golgi localization|lateral motor column neuron migration|,phosphatidylinositol 3-kinase binding|,9,1,0.672,10,2.3,2.25,1.9,2.21,0.259,-5.7,6
ENSMUSG00000021982,CDADC1,cytidine and dCMP deaminase domain containing 1,None,metabolic process|,zinc ion binding|hydrolase activity|,0,0,0,1,-3,2.33,-3,2.2,0.26,-6,1.1
ENSMUSG00000045996,POLR2K,"polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa","nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|","mRNA splicing, via spliceosome|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|regulation of transcription from RNA polymerase I promoter|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|RNA splicing|gene expression|viral process|positive regulation of type I interferon production|innate immune response|positive regulation of viral transcription|",RNA polymerase I activity|RNA polymerase II activity|RNA polymerase III activity|DNA binding|zinc ion binding|,7,2.4,0.687,6,1.3,1.73,1.4,2.2,0.26,-4.1,7
ENSMUSG00000021756,IL6ST,interleukin 6 signal transducer,extracellular region|extracellular space|plasma membrane|interleukin-6 receptor complex|oncostatin-M receptor complex|external side of plasma membrane|membrane|dendrite|neuronal cell body|extracellular vesicular exosome|ciliary neurotrophic factor receptor complex|,positive regulation of acute inflammatory response|positive regulation of adaptive immune response|glycogen metabolic process|positive regulation of cell proliferation|positive regulation of cell proliferation|regulation of Notch signaling pathway|positive regulation vascular endothelial growth factor production|positive regulation of cardiac muscle hypertrophy|viral process|cytokine-mediated signaling pathway|response to cytokine|interleukin-11-mediated signaling pathway|oncostatin-M-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of apoptotic process|positive regulation of osteoblast differentiation|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|interleukin-6-mediated signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|ciliary neurotrophic factor-mediated signaling pathway|,ciliary neurotrophic factor receptor activity|interleukin-6 receptor activity|interleukin-6 receptor activity|interleukin-11 receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|protein binding|growth factor binding|growth factor binding|interleukin-11 binding|interleukin-6 binding|protein homodimerization activity|interleukin-27 receptor activity|,6,2.9,2.71,7,-2.6,3.17,-2.3,2.2,0.26,-6.7,5.5
ENSMUSG00000036858,PTCRA,pre T-cell antigen receptor alpha,integral component of membrane|,negative regulation of thymocyte apoptotic process|,protein binding|,9,-3.4,1.89,10,1.3,0.716,1.6,2.2,0.26,-5.9,4.6
ENSMUSG00000003032,KLF4,Kruppel-like factor 4 (gut),nuclear chromatin|nucleus|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|mesodermal cell fate determination|negative regulation of cell proliferation|epidermal cell differentiation|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of muscle hyperplasia|stem cell maintenance|post-embryonic camera-type eye development|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|response to retinoic acid|negative regulation of heterotypic cell-cell adhesion|post-embryonic hemopoiesis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of phosphatidylinositol 3-kinase activity|negative regulation of interleukin-8 biosynthetic process|positive regulation of nitric oxide biosynthetic process|fat cell differentiation|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hemoglobin biosynthetic process|negative regulation of smooth muscle cell proliferation|epidermis morphogenesis|negative regulation of inflammatory response|positive regulation of protein metabolic process|negative regulation of protein kinase B signaling|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|cellular response to growth factor stimulus|cellular response to cycloheximide|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|cellular response to peptide|negative regulation of chemokine (C-X-C motif) ligand 2 production|",core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding|RNA polymerase II transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|phosphatidylinositol 3-kinase regulator activity|transcription regulatory region DNA binding|,10,-0.8,0.979,10,2.3,4.13,1.5,2.19,0.261,-3.1,5.3
ENSMUSG00000036202,RIF1,replication timing regulatory factor 1,"chromosome, telomeric region|female pronucleus|male pronucleus|nucleus|nucleolus|cytoplasm|spindle|plasma membrane|",cellular response to DNA damage stimulus|cell cycle|stem cell maintenance|,None,10,-1,1.61,10,-0.7,0.779,-0.9,2.19,0.261,-5.5,6.3
ENSMUSG00000036131,FRMD7,FERM domain containing 7,extracellular space|cytoskeleton|growth cone|neuron projection|neuronal cell body|,regulation of neuron projection development|,molecular_function|,0,0,0,1,2.9,2.31,2.9,2.19,0.261,-1.1,6
ENSMUSG00000005893,NR2C2,"nuclear receptor subfamily 2, group C, member 2",nucleus|nucleoplasm|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|spermatogenesis|nervous system development|gene expression|cerebellum development|cell differentiation|positive regulation of embryonic development|steroid hormone mediated signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of behavior|meiotic cell cycle|",sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|receptor activity|protein binding|zinc ion binding|sequence-specific DNA binding|protein heterodimerization activity|,10,-1.3,1.5,10,-1.7,0.886,-1.6,2.19,0.261,-5.9,3.3
ENSMUSG00000005233,SPC25,"SPC25, NDC80 kinetochore complex component",condensed chromosome kinetochore|nucleus|cytosol|Ndc80 complex|,mitotic cell cycle|mitotic spindle organization|chromosome segregation|mitotic nuclear division|,protein binding|,7,3.8,2.52,8,-2.4,3.06,3.4,2.19,0.261,-5.9,7.9
ENSMUSG00000028552,EPS15,epidermal growth factor receptor pathway substrate 15,cytoplasm|cytosol|plasma membrane|coated pit|membrane|AP-2 adaptor complex|early endosome membrane|intracellular membrane-bounded organelle|ciliary membrane|,Golgi to endosome transport|endocytosis|epidermal growth factor receptor signaling pathway|cell proliferation|protein transport|vesicle organization|endocytic recycling|negative regulation of epidermal growth factor receptor signaling pathway|clathrin coat assembly|,calcium ion binding|protein binding|SH3 domain binding|polyubiquitin binding|identical protein binding|,10,1.5,1.57,10,-2.8,3.13,-0.9,2.18,0.262,-8.3,3.9
ENSMUSG00000026547,TAGLN2,transgelin 2,extracellular vesicular exosome|,epithelial cell differentiation|,protein binding|,10,-0.8,0.82,10,-1.3,1.64,-1.2,2.18,0.262,-5.7,2.9
ENSMUSG00000057163,PRSS2,"protease, serine, 2 (trypsin 2)",extracellular region|extracellular region|extracellular space|extracellular matrix|,proteolysis|digestion|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell growth|collagen catabolic process|collagen catabolic process|collagen catabolic process|innate immune response|positive regulation of cell adhesion|,serine-type endopeptidase activity|calcium ion binding|protein binding|,10,0,0,10,-5.8,4.21,-1.2,2.18,0.262,-11.6,0.6
ENSMUSG00000030530,FURIN,furin (paired basic amino acid cleaving enzyme),Golgi membrane|Golgi lumen|trans-Golgi network|plasma membrane|cell surface|membrane|integral component of membrane|trans-Golgi network transport vesicle|membrane raft|extracellular vesicular exosome|,signal peptide processing|proteolysis|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|cell proliferation|regulation of signal transduction|negative regulation of endopeptidase activity|viral process|protein processing|protein processing|peptide hormone processing|peptidyl-glutamic acid carboxylation|viral life cycle|virion assembly|viral protein processing|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|nerve growth factor processing|negative regulation of low-density lipoprotein particle receptor catabolic process|nerve growth factor production|negative regulation of transforming growth factor beta1 production|secretion by cell|regulation of protein catabolic process|peptide biosynthetic process|post-translational protein modification|cellular protein metabolic process|neurotrophin TRK receptor signaling pathway|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity|,protease binding|endopeptidase activity|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity|peptidase activity|peptide binding|metal ion binding|nerve growth factor binding|,10,-0.8,0.382,10,-3.1,2.92,-1,2.18,0.262,-8.3,1.3
ENSMUSG00000033319,FEM1C,fem-1 homolog c (C. elegans),cytoplasm|,protein ubiquitination|,None,1,-4.1,2.31,0,0,0,-4.1,2.18,0.262,-8,0.9
ENSMUSG00000042462,DCTPP1,dCTP pyrophosphatase 1,cytosol|,nucleoside triphosphate catabolic process|protein homotetramerization|,magnesium ion binding|pyrimidine deoxyribonucleotide binding|nucleoside-triphosphate diphosphatase activity|dCTP diphosphatase activity|,0,0,0,1,-3,2.3,-3,2.17,0.264,-6,1.1
ENSMUSG00000030278,CIDEC,cell death-inducing DFFA-like effector c,nucleus|endoplasmic reticulum|lipid particle|cytosol|,"transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|lipid particle organization|regulation of apoptotic process|execution phase of apoptosis|",molecular_function|,10,-6.4,2.82,10,-0.4,0.125,-1.1,2.17,0.264,-12,3.3
ENSMUSG00000060509,XCR1,chemokine (C motif) receptor 1,plasma membrane|integral component of plasma membrane|,"chemotaxis|inflammatory response|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|positive regulation of cytosolic calcium ion concentration|release of sequestered calcium ion into cytosol|chemokine-mediated signaling pathway|chemokine-mediated signaling pathway|",chemokine receptor activity|,10,-2.3,3.74,10,-0.4,0.0167,-2.1,2.17,0.264,-5.7,2
ENSMUSG00000027109,SP3,Sp3 transcription factor,nucleus|PML body|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|ossification|natural killer cell differentiation|trophectodermal cell differentiation|liver development|embryonic placenta development|transcription, DNA-templated|regulation of transcription, DNA-templated|B cell differentiation|T cell differentiation|megakaryocyte differentiation|monocyte differentiation|lung development|granulocyte differentiation|enucleate erythrocyte differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|embryonic camera-type eye morphogenesis|embryonic skeletal system development|embryonic process involved in female pregnancy|definitive hemopoiesis|",RNA polymerase II core promoter sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|chromatin binding|double-stranded DNA binding|protein binding|metal ion binding|,1,2.5,2.3,0,0,0,2.5,2.17,0.264,-1.2,6
ENSMUSG00000015365,MOV10L1,Mov10 RISC complex RNA helicase like 1,intracellular|,ATP catabolic process|multicellular organismal development|germ cell development|spermatogenesis|,magnesium ion binding|RNA binding|ATP-dependent RNA helicase activity|ATP binding|,10,-1.1,1.68,10,-1.7,0.947,-1.4,2.17,0.264,-11.5,1.9
ENSMUSG00000039191,RBPJ,recombination signal binding protein for immunoglobulin kappa J region,MAML1-RBP-Jkappa- ICN1 complex|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|angiogenesis|epithelial to mesenchymal transition|blood vessel remodeling|inflammatory response to antigenic stimulus|outflow tract morphogenesis|endocardium morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac left ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA recombination|transcription initiation from RNA polymerase II promoter|humoral immune response|Notch signaling pathway|Notch signaling pathway|positive regulation of transcription of Notch receptor target|negative regulation of cell proliferation|auditory receptor cell fate commitment|epidermal cell fate specification|gene expression|pituitary gland development|B cell differentiation|keratinocyte differentiation|negative regulation of ossification|positive regulation of BMP signaling pathway|somatic stem cell maintenance|dorsal aorta morphogenesis|atrioventricular canal development|defense response to bacterium|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of timing of cell differentiation|sebaceous gland development|hair follicle maturation|positive regulation of cardiac muscle cell proliferation|Clara cell differentiation|labyrinthine layer blood vessel development|arterial endothelial cell fate commitment|Notch signaling involved in heart development|blood vessel lumenization|interleukin-4 secretion|blood vessel endothelial cell fate specification|positive regulation of ERBB signaling pathway|positive regulation of ephrin receptor signaling pathway|positive regulation of cell proliferation involved in heart morphogenesis|",recombinase activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II repressing transcription factor binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|protein N-terminus binding|,10,-2,3.79,10,0.3,0.063,-1.8,2.17,0.264,-6.1,2.5
ENSMUSG00000025077,DCLRE1A,DNA cross-link repair 1A,nucleus|,nucleotide-excision repair|mitotic nuclear division|,hydrolase activity|,10,-1.6,2.35,10,-0.4,0.379,-3.6,2.16,0.265,-10.8,1.4
ENSMUSG00000023051,TARBP2,TAR (HIV-1) RNA binding protein 2,nucleus|cytoplasm|cytosol|RISC complex|perinuclear region of cytoplasm|,"regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|regulation of translation|negative regulation of protein kinase activity|gene expression|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|pre-miRNA processing|miRNA loading onto RISC involved in gene silencing by miRNA|positive regulation of viral genome replication|regulation of viral transcription|negative regulation of defense response to virus by host|",double-stranded RNA binding|protein binding|siRNA binding|miRNA binding|protein homodimerization activity|,9,0,0,10,-1.8,3.01,-2,2.16,0.265,-6,1.1
ENSMUSG00000004270,LPCAT3,lysophosphatidylcholine acyltransferase 3,endoplasmic reticulum membrane|membrane|integral component of membrane|,phospholipid metabolic process|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|small molecule metabolic process|glycerophospholipid biosynthetic process|regulation of plasma lipoprotein particle levels|,1-acylglycerophosphocholine O-acyltransferase activity|,1,-4.1,2.29,0,0,0,-4.1,2.16,0.265,-8,1
ENSMUSG00000040287,STAC3,SH3 and cysteine rich domain 3,None,intracellular signal transduction|,identical protein binding|metal ion binding|,10,-4.2,2.85,10,-0.2,0.119,-4.2,2.16,0.265,-10.9,4.4
ENSMUSG00000019214,CHTF18,"CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)",nucleus|cytoplasm|membrane|,DNA replication|cell cycle|,DNA binding|ATP binding|nucleoside-triphosphatase activity|,0,0,0,1,2.8,2.27,2.8,2.15,0.267,-1.2,6
ENSMUSG00000031583,WRN,"Werner syndrome, RecQ helicase-like",nucleoplasm|nucleolus|centrosome|MutLalpha complex|,telomere maintenance|DNA synthesis involved in DNA repair|replicative cell aging|ATP catabolic process|ATP catabolic process|DNA metabolic process|DNA replication|base-excision repair|double-strand break repair|DNA recombination|cellular response to DNA damage stimulus|response to oxidative stress|aging|cell aging|cellular response to starvation|response to UV-C|multicellular organismal aging|replication fork processing|replication fork processing|nucleolus to nucleoplasm transport|DNA duplex unwinding|DNA duplex unwinding|DNA duplex unwinding|regulation of growth rate|regulation of apoptotic process|positive regulation of hydrolase activity|cellular response to gamma radiation|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|,magnesium ion binding|Y-form DNA binding|bubble DNA binding|DNA binding|DNA helicase activity|DNA helicase activity|ATP-dependent DNA helicase activity|helicase activity|exonuclease activity|protein binding|ATP binding|3'-5' exonuclease activity|four-way junction helicase activity|ATPase activity|manganese ion binding|protein complex binding|protein homodimerization activity|3'-5' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity|G-quadruplex DNA binding|,10,4.7,3.59,10,-1.8,2.64,-1.5,2.15,0.267,-5,8.9
ENSMUSG00000025858,GET4,golgi to ER traffic protein 4 homolog (S. cerevisiae),cytosol|BAT3 complex|,transport|tail-anchored membrane protein insertion into ER membrane|,None,0,0,0,1,2.8,2.27,2.8,2.15,0.267,-1.2,6
ENSMUSG00000024908,PPP6R3,"protein phosphatase 6, regulatory subunit 3",nucleus|cytoplasm|plasma membrane|,regulation of phosphoprotein phosphatase activity|,protein binding|protein phosphatase binding|,9,-0.8,0.631,10,-1.3,1.84,-1.1,2.15,0.267,-4.9,0.9
ENSMUSG00000025024,SMNDC1,survival motor neuron domain containing 1,nucleus|spliceosomal complex|cytoplasm|Cajal body|nuclear speck|intermediate filament cytoskeleton|,"RNA splicing, via transesterification reactions|mRNA processing|apoptotic process|RNA splicing|",protein binding|poly(A) RNA binding|,10,4,0.732,9,-1.7,3.24,-1.5,2.15,0.267,-6,6
ENSMUSG00000039741,BAHCC1,BAH domain and coiled-coil containing 1,None,None,chromatin binding|,1,-4,2.27,0,0,0,-4,2.14,0.268,-8,1
ENSMUSG00000026394,ATP6V1G3,"ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3",cytosol|cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex|,cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|hydrogen ion transmembrane transport|,"hydrogen-exporting ATPase activity, phosphorylative mechanism|ATPase binding|",8,-1.2,1.25,10,-1.1,1.06,-1.2,2.14,0.268,-4.8,2.1
ENSMUSG00000054676,1600014C10RIK,RIKEN cDNA 1600014C10 gene,mitochondrion|endoplasmic reticulum|membrane|integral component of membrane|,biological_process|,molecular_function|,1,-3.8,2.13,1,-1.8,0.486,-3.6,2.14,0.268,-8,0.8
ENSMUSG00000001150,MCM3AP,minichromosome maintenance complex component 3 associated protein,nucleus|nuclear pore|nucleoplasm|cytosol|,immune system process|DNA replication|protein import into nucleus|mRNA transport|,"DNA binding|transferase activity, transferring acyl groups|",8,1.9,1.83,8,1.5,0.523,1.8,2.14,0.268,-4.3,5
ENSMUSG00000031861,LPAR2,lysophosphatidic acid receptor 2,plasma membrane|integral component of plasma membrane|cell surface|endocytic vesicle|,activation of MAPK activity|G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|positive regulation of Rho protein signal transduction|,G-protein coupled receptor activity|protein binding|lipid binding|PDZ domain binding|lysophosphatidic acid receptor activity|,0,0,0,2,2.2,2.26,2.2,2.13,0.269,-1.2,5
ENSMUSG00000031289,IL13RA2,"interleukin 13 receptor, alpha 2",extracellular space|integral component of membrane|,signal transduction|cytokine-mediated signaling pathway|cytokine-mediated signaling pathway|,signal transducer activity|cytokine receptor activity|,10,-4,2.73,10,0.9,0.283,-3.8,2.13,0.269,-10.4,3.4
ENSMUSG00000030612,MRPL46,mitochondrial ribosomal protein L46,cellular_component|mitochondrion|ribosome|,biological_process|metabolic process|,molecular_function|hydrolase activity|,9,-2.7,2.35,10,2.7,1.5,-2.9,2.13,0.269,-8,6.5
ENSMUSG00000022814,UMPS,uridine monophosphate synthetase,nucleus|cytoplasm|cytosol|,pyrimidine nucleobase metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|UMP biosynthetic process|female pregnancy|lactation|cellular response to drug|'de novo' UMP biosynthetic process|small molecule metabolic process|pyrimidine nucleoside biosynthetic process|nucleobase-containing small molecule metabolic process|,orotate phosphoribosyltransferase activity|orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity|orotidine-5'-phosphate decarboxylase activity|,10,1.1,1.24,10,-1.3,1.61,-1.9,2.13,0.269,-5.8,3
ENSMUSG00000048647,EXD1,exonuclease 3'-5' domain containing 1,None,nucleic acid phosphodiester bond hydrolysis|,nucleic acid binding|3'-5' exonuclease activity|,1,2.4,2.26,0,0,0,2.4,2.13,0.269,-1.2,6
ENSMUSG00000021368,TBC1D7,"TBC1 domain family, member 7",cytoplasmic membrane-bounded vesicle|cytoplasmic vesicle|,positive regulation of protein ubiquitination|negative regulation of TOR signaling|positive regulation of Rab GTPase activity|activation of Rho GTPase activity|response to growth factor|,Rab GTPase activator activity|protein binding|,0,0,0,1,-3,2.26,-3,2.13,0.269,-6,1.1
ENSMUSG00000022659,GCSAM,"germinal center-associated, signaling and motility",cytoplasm|plasma membrane|,regulation of B cell receptor signaling pathway|negative regulation of lymphocyte migration|,actin binding|protein binding|protein kinase binding|myosin II binding|,1,2.4,2.26,0,0,0,2.4,2.13,0.269,-1.2,6
ENSMUSG00000051890,KLHDC1,kelch domain containing 1,cytoplasm|,None,None,0,0,0,1,-3,2.26,-3,2.13,0.269,-6,1.1
ENSMUSG00000069835,SAT2,spermidine/spermine N1-acetyltransferase family member 2,cytoplasm|extracellular vesicular exosome|,putrescine catabolic process|spermidine acetylation|spermine acetylation|putrescine acetylation|nor-spermidine metabolic process|,diamine N-acetyltransferase activity|,10,-4.4,2.71,10,-0.5,0.342,-1.2,2.13,0.269,-10.4,1.2
ENSMUSG00000061524,ZIC2,Zic family member 2,nucleus|cytoplasm|,"neural tube closure|transcription, DNA-templated|brain development|visual perception|retinal ganglion cell axon guidance|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|developmental pigmentation|positive regulation of sequence-specific DNA binding transcription factor activity|",DNA binding|sequence-specific DNA binding transcription factor activity|chromatin DNA binding|metal ion binding|,10,2.2,3.56,10,-0.3,0.0241,1.9,2.13,0.269,-3,5.3
ENSMUSG00000001985,GRIK3,"glutamate receptor, ionotropic, kainate 3",plasma membrane|integral component of plasma membrane|cell junction|axon|dendrite|dendrite|dendrite cytoplasm|kainate selective glutamate receptor complex|presynaptic membrane|terminal bouton|perikaryon|postsynaptic membrane|,"adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|synaptic transmission|ion transmembrane transport|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|regulation of membrane potential|regulation of membrane potential|negative regulation of synaptic transmission, glutamatergic|",adenylate cyclase inhibiting G-protein coupled glutamate receptor activity|ionotropic glutamate receptor activity|ionotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|glutamate receptor activity|kainate selective glutamate receptor activity|,1,-4,2.26,0,0,0,-4,2.13,0.269,-8,1
ENSMUSG00000007987,RABL5,N/A,None,None,None,0,0,0,1,-3,2.26,-3,2.13,0.269,-6,1.1
ENSMUSG00000005625,PSMD4,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 4","proteasome complex|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle, base subcomplex|proteasome accessory complex|","G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|identical protein binding|poly(A) RNA binding|,8,-3.2,1.57,6,-1.7,0.954,-3.2,2.13,0.269,-6.5,3.5
ENSMUSG00000032586,TRAIP,TRAF interacting protein,nucleolus|perinuclear region of cytoplasm|,apoptotic process|signal transduction|cell proliferation|protein ubiquitination|intracellular signal transduction|,receptor signaling protein activity|protein binding|zinc ion binding|ligase activity|,10,2.5,2.66,10,-1.8,3.08,-1.5,2.12,0.271,-4.7,5.8
ENSMUSG00000060170,OLFR1371,olfactory receptor 1371,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-1.5,0.631,1,3,2.68,3,2.12,0.271,-2.2,6
ENSMUSG00000030960,METTL10,methyltransferase like 10,None,methylation|,methyltransferase activity|,10,0,0,10,-2.4,4.31,-1.9,2.11,0.272,-6.4,2.3
ENSMUSG00000037826,PPM1K,"protein phosphatase, Mg2+/Mn2+ dependent, 1K",mitochondrion|mitochondrial matrix|,protein dephosphorylation|,protein serine/threonine phosphatase activity|metal ion binding|,0,0,0,1,2.8,2.24,2.8,2.11,0.272,-1.2,6
ENSMUSG00000021356,IRF4,interferon regulatory factor 4,nuclear nucleosome|nucleus|cytosol|membrane|,"transcription, DNA-templated|peptidyl-lysine methylation|cytokine-mediated signaling pathway|negative regulation of toll-like receptor signaling pathway|T cell activation|defense response to protozoan|myeloid dendritic cell differentiation|positive regulation of DNA binding|histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|regulation of T-helper cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|T-helper 17 cell lineage commitment|",regulatory region DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein-lysine N-methyltransferase activity|sequence-specific DNA binding|,10,-0.5,0.443,10,-5.5,2.44,-0.9,2.11,0.272,-10.4,2
ENSMUSG00000053644,ALDH7A1,"aldehyde dehydrogenase 7 family, member A1",nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|extracellular vesicular exosome|,cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound|glycine betaine biosynthetic process from choline|cellular nitrogen compound metabolic process|small molecule metabolic process|oxidation-reduction process|,aldehyde dehydrogenase (NAD) activity|L-aminoadipate-semialdehyde dehydrogenase activity|protein binding|betaine-aldehyde dehydrogenase activity|,9,-1.4,3,10,0,0,-1.2,2.11,0.272,-4,2.2
ENSMUSG00000064057,SCGB3A1,"secretoglobin, family 3A, member 1",extracellular space|extracellular vesicular exosome|,negative regulation of cell growth|regulation of cell proliferation|,cytokine activity|,10,1.7,1.38,10,2.5,1.05,2,2.11,0.272,-4.2,7
ENSMUSG00000027937,JTB,jumping translocation breakpoint,cytoplasm|mitochondrion|centrosome|spindle|integral component of plasma membrane|membrane|midbody|,cytokinesis|mitotic nuclear division|apoptotic mitochondrial changes|regulation of cell proliferation|positive regulation of protein kinase activity|,protein kinase binding|,10,1.3,2.18,10,-2.8,0.963,1.1,2.1,0.274,-6.6,5.1
ENSMUSG00000059436,MAX,MYC associated factor X,nucleus|cytoplasm|PML body|dendrite|MLL1 complex|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein complex assembly|cellular response to starvation|negative regulation of gene expression|response to insulin|response to axon injury|neuron apoptotic process|retina development in camera-type eye|cellular response to peptide hormone stimulus|",sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription coactivator activity|protein binding|protein complex binding|protein homodimerization activity|sequence-specific DNA binding|protein heterodimerization activity|,10,-1.5,0.855,10,-1.3,1.42,-1.4,2.1,0.274,-4.8,1.3
ENSMUSG00000073729,GM6420,predicted gene 6420,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-3,2.23,-3,2.1,0.274,-6,1.1
ENSMUSG00000026259,NGEF,neuronal guanine nucleotide exchange factor,cytosol|membrane|growth cone|,small GTPase mediated signal transduction|positive regulation of Rho GTPase activity|positive regulation of apoptotic process|regulation of GTPase activity|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of dendritic spine morphogenesis|apoptotic signaling pathway|,Rho guanyl-nucleotide exchange factor activity|,9,-6.5,3.65,9,-0.2,0.0417,-1.5,2.1,0.274,-12.3,2.1
ENSMUSG00000036845,LIN37,lin-37 DREAM MuvB core complex component,nucleoplasm|transcriptional repressor complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|regulation of cell cycle|,protein binding|,10,5.1,3.09,10,1.3,1.28,1.1,2.1,0.274,-2.5,10.5
ENSMUSG00000074903,GM2058,ubiquitin-conjugating enzyme E2H pseudogene,None,None,None,7,2.1,3.64,6,0,0,1.9,2.1,0.274,-1.6,6.5
ENSMUSG00000030662,IPO5,importin 5,nucleus|nucleus|nuclear pore|cytoplasm|cytoplasm|Golgi apparatus|membrane|nuclear membrane|intracellular membrane-bounded organelle|,NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|viral process|positive regulation of protein import into nucleus|negative regulation of catalytic activity|cellular response to amino acid stimulus|,GTPase inhibitor activity|protein binding|Ran GTPase binding|protein transporter activity|poly(A) RNA binding|,10,-0.8,1.31,10,-1.2,1.04,-0.9,2.1,0.274,-4.5,1.8
ENSMUSG00000046093,HPCAL4,hippocalcin like 4,intracellular|,central nervous system development|,calcium channel regulator activity|calcium ion binding|protein C-terminus binding|protein domain specific binding|,10,1.5,2.33,10,0.5,0.33,1.4,2.1,0.274,-4.1,4.4
ENSMUSG00000029430,RAN,"RAN, member RAS oncogene family",chromatin|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|membrane|melanosome|extracellular vesicular exosome|,"ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|GTP catabolic process|DNA metabolic process|protein export from nucleus|mitotic spindle organization|mitotic nuclear division|signal transduction|small GTPase mediated signal transduction|gene expression|viral process|viral life cycle|androgen receptor signaling pathway|positive regulation of protein binding|small molecule metabolic process|positive regulation of transcription, DNA-templated|intracellular transport of virus|",chromatin binding|transcription coactivator activity|GTPase activity|protein binding|GTP binding|protein domain specific binding|poly(A) RNA binding|androgen receptor binding|,4,-2.2,0.941,4,-4.2,1.72,-2.5,2.1,0.274,-8,2.4
ENSMUSG00000062526,MPPE1,metallophosphoesterase 1,endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|endoplasmic reticulum exit site|,GPI anchor biosynthetic process|ER to Golgi vesicle-mediated transport|,phosphoric diester hydrolase activity|manganese ion binding|GPI anchor binding|,1,-4,2.23,0,0,0,-4,2.1,0.274,-8,1
ENSMUSG00000000682,CD52,CD52 molecule,integral component of plasma membrane|membrane|anchored component of membrane|,positive regulation of cytosolic calcium ion concentration|respiratory burst|,None,10,-3.3,2.75,10,-1.2,0.502,-1.3,2.09,0.275,-6.4,1.9
ENSMUSG00000027298,TYRO3,TYRO3 protein tyrosine kinase,nucleus|nuclear envelope|endoplasmic reticulum membrane|integral component of plasma membrane|,natural killer cell differentiation|cell adhesion|signal transduction|spermatogenesis|phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|forebrain cell migration|signal transduction by phosphorylation|platelet activation|secretion by cell|negative regulation of toll-like receptor signaling pathway|substrate adhesion-dependent cell spreading|ovulation cycle|apoptotic cell clearance|protein kinase B signaling|negative regulation of neuron apoptotic process|negative regulation of innate immune response|protein autophosphorylation|negative regulation of inflammatory response|negative regulation of lymphocyte activation|vagina development|neuron cellular homeostasis|platelet aggregation|,protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity|protein binding|ATP binding|phosphatidylinositol 3-kinase binding|protein heterodimerization activity|,8,-0.7,0.513,9,-3.3,2.93,-0.9,2.09,0.275,-8.8,2.5
ENSMUSG00000026439,RBBP5,retinoblastoma binding protein 5,nucleus|nucleolus|histone methyltransferase complex|histone methyltransferase complex|Set1C/COMPASS complex|MLL1 complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|response to estrogen|histone H3-K4 methylation|",protein binding|methylated histone binding|histone methyltransferase activity (H3-K4 specific)|transcription regulatory region DNA binding|,1,2.4,2.22,0,0,0,2.4,2.09,0.275,-1.2,6
ENSMUSG00000096645,SPIN2E,"spindlin family, member 2E",None,None,None,3,-2.9,1.03,5,-2.8,1.22,-2.8,2.09,0.275,-8,2.9
ENSMUSG00000035382,PCSK7,proprotein convertase subtilisin/kexin type 7,integral component of Golgi membrane|,proteolysis|protein processing|peptide hormone processing|,serine-type endopeptidase activity|peptidase activity|,10,-0.6,0.239,10,-2,2.87,-1.8,2.09,0.275,-9,2.3
ENSMUSG00000057836,XLR3A,X-linked lymphocyte-regulated 3A,cellular_component|,biological_process|,molecular_function|,4,-4.5,2.16,3,5.2,4.07,5.1,2.08,0.276,-7.7,10
ENSMUSG00000021277,TRAF3,TNF receptor-associated factor 3,mitochondrion|endosome|cytosol|cytoplasmic side of plasma membrane|CD40 receptor complex|,regulation of cytokine production|toll-like receptor signaling pathway|toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|apoptotic process|signal transduction|Toll signaling pathway|protein ubiquitination|regulation of proteolysis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of interferon-beta production|tumor necrosis factor-mediated signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|regulation of apoptotic process|innate immune response|regulation of defense response to virus|,ubiquitin-protein transferase activity|signal transducer activity|tumor necrosis factor receptor binding|protein binding|zinc ion binding|ligase activity|protein kinase binding|ubiquitin protein ligase binding|thioesterase binding|,10,-4.1,0.511,10,-1.9,2.03,-1.7,2.08,0.276,-6.9,1.2
ENSMUSG00000031109,ENOX2,ecto-NOX disulfide-thiol exchanger 2,extracellular space|cytosol|external side of plasma membrane|,ultradian rhythm|cell growth|regulation of growth|oxidation-reduction process|,nucleotide binding|nucleic acid binding|protein disulfide oxidoreductase activity|,1,-3.9,2.2,0,0,0,-3.9,2.08,0.276,-8,1
ENSMUSG00000040549,CKAP5,cytoskeleton associated protein 5,spindle pole|gamma-tubulin complex|centrosome|cytosol|microtubule cytoskeleton|membrane|microtubule plus-end|protein complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle organization|mitotic nuclear division|establishment or maintenance of microtubule cytoskeleton polarity|RNA transport|centrosome organization|,protein binding|,7,-3.2,1.4,6,2.7,2.79,1.7,2.08,0.276,-8.3,6.8
ENSMUSG00000020072,PBLD1,phenazine biosynthesis-like protein domain containing 1,cytoplasm|extracellular vesicular exosome|,biosynthetic process|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of SMAD protein import into nucleus|negative regulation of pathway-restricted SMAD protein phosphorylation|,molecular_function|catalytic activity|carnitine racemase activity|isomerase activity|NADHX epimerase activity|NADPHX epimerase activity|,1,-3.9,2.21,0,0,0,-3.9,2.08,0.276,-8,1
ENSMUSG00000041476,SMPX,"small muscle protein, X-linked",nucleus|muscle tendon junction|M band|costamere|,striated muscle contraction|,None,10,-4.4,2.8,9,-0.1,0.0167,-1.3,2.08,0.276,-8,1.2
ENSMUSG00000025917,COPS5,COP9 signalosome subunit 5,nucleus|cytoplasm|eukaryotic translation initiation factor 3 complex|synaptic vesicle|COP9 signalosome|cell junction|perinuclear region of cytoplasm|,protein deneddylation|transcription from RNA polymerase II promoter|translation|translational initiation|proteolysis|cullin deneddylation|protein deubiquitination|positive regulation of transcription from RNA polymerase II promoter|regulation of JNK cascade|regulation of cell cycle|exosomal secretion|,transcription coactivator activity|translation initiation factor activity|ubiquitin-specific protease activity|protein binding|metallopeptidase activity|metal ion binding|,1,-5.7,2.57,1,-1.2,0.202,-5.5,2.08,0.276,-11,0.6
ENSMUSG00000040610,TLX3,T-cell leukemia homeobox 3,nucleus|,"neuron migration|regulation of respiratory gaseous exchange by neurological system process|regulation of transcription, DNA-templated|central nervous system development|respiratory gaseous exchange|negative regulation of neuron differentiation|neuron fate specification|",sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,10,1.3,0.661,10,-1.3,1.69,-1.4,2.07,0.277,-5.1,2.5
ENSMUSG00000032415,UBE2CBP,ubiquitin-conjugating enzyme E2C binding protein,cellular_component|cytoplasm|,biological_process|,"molecular_function|UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity|ligase activity|ribosomal S6-glutamic acid ligase activity|coenzyme F420-0 gamma-glutamyl ligase activity|coenzyme F420-2 alpha-glutamyl ligase activity|protein-glycine ligase activity|protein-glycine ligase activity, initiating|protein-glycine ligase activity, elongating|tubulin-glycine ligase activity|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|",1,-3.9,2.2,0,0,0,-3.9,2.07,0.277,-8,1
ENSMUSG00000029559,2210016L21RIK,RIKEN cDNA 2210016L21 gene,cellular_component|,biological_process|,molecular_function|,1,-3.9,2.19,0,0,0,-3.9,2.07,0.277,-8,1
ENSMUSG00000033282,RPGRIP1L,RPGRIP1-like,cytoplasm|centrosome|cell-cell junction|tight junction|cilium|axoneme|ciliary basal body|,in utero embryonic development|kidney development|liver development|establishment or maintenance of cell polarity|determination of left/right symmetry|regulation of smoothened signaling pathway|neural tube patterning|cerebellum development|lateral ventricle development|olfactory bulb development|corpus callosum development|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|cilium assembly|camera-type eye development|nose development|negative regulation of G-protein coupled receptor protein signaling pathway|pericardium development|head development|,protein binding|thromboxane A2 receptor binding|,10,-1.3,2,10,-0.6,0.399,-1.1,2.07,0.277,-10.1,3.3
ENSMUSG00000006586,RUNX1T1,"runt-related transcription factor 1; translocated to, 1 (cyclin D-related)",nuclear matrix|,"generation of precursor metabolites and energy|transcription, DNA-templated|regulation of transcription, DNA-templated|fat cell differentiation|regulation of DNA binding|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|identical protein binding|protein homodimerization activity|metal ion binding|,10,1.2,2.1,10,-0.6,0.163,1.2,2.07,0.277,-2.4,3.5
ENSMUSG00000082639,GM2012,predicted gene 2012,cellular_component|,biological_process|,molecular_function|,2,-2.9,2.48,3,1.8,0.281,-2.7,2.05,0.28,-6,2.8
ENSMUSG00000030034,INO80B,INO80 complex subunit B,nucleus|nucleolus|cytoplasm|plasma membrane|Ino80 complex|,"DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|",protein binding|metal ion binding|,0,0,0,2,-3.2,2.18,-3.2,2.05,0.28,-6,2.2
ENSMUSG00000096743,VMN2R32,"vomeronasal 2, receptor 32",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,5,-1.5,1.49,5,-4.7,1.05,-3.4,2.05,0.28,-8.8,2.2
ENSMUSG00000047220,CCDC36,coiled-coil domain containing 36,None,None,None,1,2.6,2.62,1,-2.8,1.68,2.6,2.05,0.28,-4.3,6
ENSMUSG00000021306,GPR137B,G protein-coupled receptor 137B,lysosomal membrane|integral component of plasma membrane|membrane|,None,None,1,2.4,2.18,0,0,0,2.4,2.05,0.28,-1.2,6
ENSMUSG00000059263,USP47,ubiquitin specific peptidase 47,cytoplasm|SCF ubiquitin ligase complex|,"base-excision repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|negative regulation of G2/M transition of mitotic cell cycle|positive regulation of cell growth|cellular response to UV|monoubiquitinated protein deubiquitination|response to drug|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|",ubiquitin-specific protease activity|protein binding|WD40-repeat domain binding|,1,2.4,2.18,0,0,0,2.4,2.05,0.28,-1.2,6
ENSMUSG00000038677,SCUBE3,"signal peptide, CUB domain, EGF-like 3",extracellular region|cell surface|,protein homooligomerization|protein heterooligomerization|,calcium ion binding|protein binding|,1,2.4,2.18,0,0,0,2.4,2.05,0.28,-1.2,6
ENSMUSG00000060187,LRRC10,leucine rich repeat containing 10,nucleus|mitochondrion|cytoskeleton|sarcomere|,cardiac muscle cell development|,actin binding|alpha-actinin binding|,0,0,0,1,2.8,2.16,2.8,2.04,0.281,-1.2,6
ENSMUSG00000054312,MRPS21,mitochondrial ribosomal protein S21,mitochondrial small ribosomal subunit|,translation|,structural constituent of ribosome|poly(A) RNA binding|,0,0,0,1,2.8,2.16,2.8,2.04,0.281,-1.2,6
ENSMUSG00000085584,RGAG1,retrotransposon gag domain containing 1,None,None,None,9,-2.8,3.12,9,-0.4,0.175,-2.3,2.04,0.281,-7.9,3.5
ENSMUSG00000044749,ABCA6,"ATP-binding cassette, sub-family A (ABC1), member 6",integral component of membrane|,ATP catabolic process|transport|,ATP binding|ATPase activity|,10,-0.7,0.613,10,-2,2,-1.3,2.04,0.281,-6.1,5
ENSMUSG00000033096,APMAP,adipocyte plasma membrane associated protein,cell surface|membrane|integral component of membrane|extracellular vesicular exosome|,biological_process|biosynthetic process|,arylesterase activity|strictosidine synthase activity|,0,0,0,1,2.8,2.16,2.8,2.04,0.281,-1.2,6
ENSMUSG00000022867,USP25,ubiquitin specific peptidase 25,nucleus|cytoplasm|,cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|protein K63-linked deubiquitination|protein K48-linked deubiquitination|,ubiquitin-specific protease activity|protein binding|peptidase activity|SUMO binding|,0,0,0,1,2.8,2.16,2.8,2.04,0.281,-1.2,6
ENSMUSG00000026457,ADIPOR1,adiponectin receptor 1,plasma membrane|membrane|integral component of membrane|,hormone-mediated signaling pathway|fatty acid oxidation|negative regulation of cell growth|leptin-mediated signaling pathway|adiponectin-activated signaling pathway|positive regulation of JAK-STAT cascade|positive regulation of insulin receptor signaling pathway|,receptor activity|protein kinase binding|hormone binding|identical protein binding|protein heterodimerization activity|,0,0,0,2,2.5,2.16,2.5,2.04,0.281,-1.2,5
ENSMUSG00000036061,SMUG1,single-strand-selective monofunctional uracil-DNA glycosylase 1,nucleoplasm|nucleolus|,"DNA catabolic process, endonucleolytic|DNA repair|base-excision repair|base-excision repair|base-excision repair, AP site formation|depyrimidination|",oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA binding|uracil DNA N-glycosylase activity|protein binding|single-strand selective uracil DNA N-glycosylase activity|DNA N-glycosylase activity|,10,-0.9,0.631,10,-0.9,1.57,-0.9,2.04,0.281,-6.6,2.4
ENSMUSG00000027680,FXR1,"fragile X mental retardation, autosomal homolog 1",nucleolus|cytoplasm|polysome|membrane|costamere|,apoptotic process|muscle organ development|negative regulation of translation|cell differentiation|,G-quadruplex RNA binding|RNA binding|mRNA 3'-UTR binding|poly(A) RNA binding|,10,1.2,0.523,10,1.7,1.76,1.3,2.04,0.281,-3,4.5
ENSMUSG00000028086,FBXW7,"F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase",nucleus|nucleoplasm|nucleoplasm|nucleolus|endoplasmic reticulum|Golgi apparatus|SCF ubiquitin ligase complex|protein complex|,"vasculogenesis|vasculature development|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|sister chromatid cohesion|Notch signaling pathway|negative regulation of triglyceride biosynthetic process|regulation of lipid storage|viral process|protein ubiquitination|lung development|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of DNA endoreduplication|regulation of protein localization|cellular response to UV|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|protein stabilization|lipid homeostasis|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of hepatocyte proliferation|negative regulation of SREBP signaling pathway|",sequence-specific DNA binding transcription factor activity|protein binding|identical protein binding|,10,0.2,0.0641,10,-1.9,2.89,-1.6,2.04,0.281,-5.3,1.4
ENSMUSG00000007080,POLE,"polymerase (DNA directed), epsilon, catalytic subunit",nucleus|nucleoplasm|cytoplasm|plasma membrane|epsilon DNA polymerase complex|,"G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA synthesis involved in DNA repair|in utero embryonic development|DNA replication|DNA replication initiation|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair, gap-filling|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|","nucleotide binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|zinc ion binding|4 iron, 4 sulfur cluster binding|",6,-2.9,0.97,6,-1.3,1.8,-2.4,2.04,0.281,-6.7,2.6
ENSMUSG00000024797,VPS51,vacuolar protein sorting 51 homolog (S. cerevisiae),GARP complex|Golgi apparatus|integral component of membrane|,"lipid transport|autophagy|protein transport|retrograde transport, endosome to Golgi|",molecular_function|protein binding|,0,0,0,1,2.8,2.16,2.8,2.04,0.281,-1.2,6
ENSMUSG00000000126,WNT9A,"wingless-type MMTV integration site family, member 9A",extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular vesicular exosome|,mitotic cell cycle checkpoint|cell-cell signaling|multicellular organismal development|negative regulation of cell proliferation|Wnt signaling pathway|neuron differentiation|neuron differentiation|negative regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cell fate commitment|positive regulation of cell differentiation|positive regulation of smoothened signaling pathway|embryonic skeletal system morphogenesis|canonical Wnt signaling pathway|negative regulation of cell death|negative regulation of cartilage development|iris morphogenesis|cornea development in camera-type eye|cellular response to retinoic acid|embryonic skeletal joint development|,frizzled binding|,9,1.7,2.85,9,-1.2,0.856,1.1,2.03,0.282,-5.5,4.8
ENSMUSG00000032264,ZW10,zw10 kinetochore protein,kinetochore|condensed chromosome kinetochore|spindle pole|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|kinetochore microtubule|cytosol|membrane|,mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|protein complex assembly|ER to Golgi vesicle-mediated transport|mitotic metaphase plate congression|mitotic cell cycle checkpoint|regulation of exit from mitosis|meiotic nuclear division|protein transport|protein localization to kinetochore|,protein binding|centromeric DNA binding|,0,0,0,1,-3,2.15,-3,2.03,0.282,-6,1.2
ENSMUSG00000047789,SLC38A9,"solute carrier family 38, member 9",integral component of membrane|,sodium ion transport|amino acid transport|,None,0,0,0,1,-3,2.15,-3,2.03,0.282,-6,1.2
ENSMUSG00000026725,TNN,tenascin N,cellular_component|proteinaceous extracellular matrix|cell surface|,cell-matrix adhesion|axonogenesis|cell growth|cell migration|,molecular_function|integrin binding|identical protein binding|,10,0,0,10,-1.9,2.53,-1.1,2.03,0.282,-5.1,2.1
ENSMUSG00000031976,URB2,URB2 ribosome biogenesis 2 homolog (S. cerevisiae),nucleus|nucleolus|aggresome|,None,None,9,1.5,3.52,8,-2.1,1.82,1.2,2.02,0.284,-6.6,5.2
ENSMUSG00000057228,AADAT,aminoadipate aminotransferase,mitochondrial matrix|,2-oxoglutarate metabolic process|glutamate metabolic process|lysine catabolic process|tryptophan catabolic process|biosynthetic process|tryptophan catabolic process to kynurenine|L-lysine catabolic process to acetyl-CoA via saccharopine|cellular nitrogen compound metabolic process|small molecule metabolic process|kynurenine metabolic process|L-kynurenine metabolic process|L-kynurenine metabolic process|L-kynurenine metabolic process|,kynurenine-oxoglutarate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|2-aminoadipate transaminase activity|2-aminoadipate transaminase activity|,10,-2.9,1.93,10,-1.4,1.15,-2.4,2.02,0.284,-7.9,1
ENSMUSG00000022434,FAM118A,"family with sequence similarity 118, member A",integral component of membrane|,None,None,10,2.4,2.72,10,0,0,2.4,2.02,0.284,-1.2,6.9
ENSMUSG00000030538,CIB1,calcium and integrin binding 1 (calmyrin),nucleus|nucleoplasm|cytoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|membrane|apical plasma membrane|lamellipodium|growth cone|filopodium tip|ruffle membrane|sarcolemma|neuron projection|neuronal cell body|perinuclear region of cytoplasm|extracellular vesicular exosome|cell periphery|,angiogenesis|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of cell-matrix adhesion|response to ischemia|double-strand break repair|apoptotic process|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|endomitotic cell cycle|cell adhesion|spermatid development|positive regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of neuron projection development|platelet formation|positive regulation of cell growth|positive regulation of cell migration|cytoplasmic microtubule organization|positive regulation of cell adhesion mediated by integrin|thrombopoietin-mediated signaling pathway|regulation of cell proliferation|negative regulation of apoptotic process|negative regulation of megakaryocyte differentiation|positive regulation of metalloenzyme activity|positive regulation of NF-kappaB transcription factor activity|cell division|regulation of cell division|negative regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|positive regulation of protein serine/threonine kinase activity|positive regulation of establishment of protein localization to plasma membrane|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|extrinsic apoptotic signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of gene expression involved in extracellular matrix organization|cellular response to nerve growth factor stimulus|positive regulation of male germ cell proliferation|,calcium ion binding|protein binding|Ras GTPase binding|protein anchor|ion channel binding|,10,-5.7,4.91,10,1.3,0.91,-5.6,2.02,0.284,-10.5,2.5
ENSMUSG00000049281,SCN3B,"sodium channel, voltage-gated, type III, beta subunit",voltage-gated sodium channel complex|voltage-gated sodium channel complex|plasma membrane|integral component of membrane|Z disc|,sodium ion transport|axon guidance|positive regulation of heart rate|positive regulation of sodium ion transport|positive regulation of sodium ion transport|sensory perception of pain|sodium ion transmembrane transport|membrane depolarization|cardiac muscle contraction|regulation of atrial cardiac muscle cell membrane depolarization|regulation of ventricular cardiac muscle cell membrane depolarization|protein localization to plasma membrane|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell to atrial cardiac muscle cell communication|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity|,voltage-gated sodium channel activity|sodium channel regulator activity|sodium channel regulator activity|ion channel binding|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|,10,-5.3,4.73,10,0.9,0.43,-5.1,2.01,0.285,-10.4,2.2
ENSMUSG00000058799,NAP1L1,nucleosome assembly protein 1-like 1,nucleus|membrane|melanosome|,DNA replication|nucleosome assembly|positive regulation of cell proliferation|,protein binding|poly(A) RNA binding|,9,-2.2,0.92,9,6.4,3.68,6.2,2.01,0.285,-3.4,12.4
ENSMUSG00000006398,CDC20,cell division cycle 20,spindle pole|nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|spindle|cytosol|perinuclear region of cytoplasm|,mitotic cell cycle|cell cycle|mitotic nuclear division|mitotic spindle assembly checkpoint|positive regulation of cell proliferation|protein ubiquitination|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of synaptic plasticity|regulation of meiosis|regulation of dendrite development|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|activation of anaphase-promoting complex activity|positive regulation of synapse maturation|,protein binding|protein C-terminus binding|enzyme binding|,9,1.8,1.9,8,0.7,0.481,1.1,2.01,0.285,-3.2,5.3
ENSMUSG00000030069,PROK2,prokineticin 2,extracellular region|,activation of MAPK activity|angiogenesis|chemotaxis|inflammatory response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|spermatogenesis|circadian rhythm|cell proliferation|sensory perception of pain|negative regulation of apoptotic process|positive regulation of smooth muscle contraction|,G-protein coupled receptor binding|,9,-0.3,0.127,10,-1.4,2.38,-1.2,2.01,0.285,-5.2,4.4
ENSMUSG00000040242,FGFR1OP2,FGFR1 oncogene partner 2,cytosol|,wound healing|,protein homodimerization activity|,1,2.4,2.13,0,0,0,2.4,2.01,0.285,-1.2,6
ENSMUSG00000049940,PGRMC2,progesterone receptor membrane component 2,membrane|integral component of membrane|,steroid hormone mediated signaling pathway|,steroid hormone receptor activity|steroid binding|heme binding|,10,3,2.97,10,0.5,0.251,2.4,2.01,0.285,-3.9,8.5
ENSMUSG00000036769,WDR44,WD repeat domain 44,Golgi apparatus|cytosol|endosome membrane|perinuclear region of cytoplasm|,None,None,0,0,0,1,2.8,2.12,2.8,2,0.286,-1.2,6
ENSMUSG00000020576,NBAS,neuroblastoma amplified sequence,cytoplasm|membrane|,"nuclear-transcribed mRNA catabolic process|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|",None,9,-1.5,2.82,9,-0.1,0.00824,-1.2,2,0.286,-5.4,2.2
ENSMUSG00000076750,TCRG-V3,"T cell receptor gamma, variable 3",external side of plasma membrane|,None,None,4,2.7,2.26,4,-5.1,3.91,-5,2,0.286,-10,5
ENSMUSG00000028041,ADAM15,ADAM metallopeptidase domain 15,acrosomal vesicle|plasma membrane|adherens junction|integral component of membrane|cell projection|,angiogenesis|proteolysis|cell-matrix adhesion|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|tissue regeneration|cardiac epithelial to mesenchymal transition|,metalloendopeptidase activity|protein binding|metallopeptidase activity|zinc ion binding|SH3 domain binding|,9,-6,5.03,10,-0.2,0.0262,-5.9,2,0.286,-11.6,2.6
ENSMUSG00000022681,NTAN1,N-terminal asparagine amidase,nucleus|cytoplasm|,memory|metabolic process|adult locomotory behavior|,protein-N-terminal asparagine amidohydrolase activity|,10,3.1,0.615,10,-2,2.87,-1.7,2,0.286,-6.6,4.3
ENSMUSG00000028527,AK4,adenylate kinase 4,mitochondrion|mitochondrial matrix|extracellular vesicular exosome|,liver development|nucleoside diphosphate phosphorylation|ADP biosynthetic process|brain development|nucleoside triphosphate biosynthetic process|response to drug|AMP metabolic process|ATP metabolic process|GTP metabolic process|,adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity|,1,-3.8,2.12,0,0,0,-3.8,2,0.286,-7,1.1
ENSMUSG00000078651,AOC2,"amine oxidase, copper containing 2 (retina-specific)",cytoplasm|plasma membrane|,catecholamine metabolic process|visual perception|amine metabolic process|oxidation-reduction process|,copper ion binding|primary amine oxidase activity|electron carrier activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|,9,-1.2,0.72,9,3,2.2,3,1.99,0.287,-2.2,7.1
ENSMUSG00000046079,LRRC8D,"leucine rich repeat containing 8 family, member D",endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|,ion transport|,protein binding|,1,2.6,2.56,1,-0.3,0.0258,2.5,1.99,0.287,-1.2,6
ENSMUSG00000031532,TMEM66,N/A,None,None,None,0,0,0,1,-2.9,2.11,-2.9,1.99,0.287,-5,1.3
ENSMUSG00000008999,BMP7,bone morphogenetic protein 7,extracellular region|extracellular space|extracellular matrix|membrane-bounded vesicle|,"skeletal system development|ossification|metanephros development|ureteric bud development|mesoderm formation|mesonephros development|epithelial to mesenchymal transition|axon guidance|embryonic pattern specification|negative regulation of striated muscle cell apoptotic process|positive regulation of peptidyl-threonine phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|dendrite development|extracellular matrix organization|embryonic limb morphogenesis|positive regulation of bone mineralization|BMP signaling pathway|epithelial cell differentiation|negative regulation of NF-kappaB transcription factor activity|response to estradiol|response to vitamin D|positive regulation of heterotypic cell-cell adhesion|protein localization to nucleus|growth|negative regulation of phosphorylation|negative regulation of NF-kappaB import into nucleus|odontogenesis of dentin-containing tooth|positive regulation of apoptotic process|steroid hormone mediated signaling pathway|negative regulation of MAP kinase activity|response to peptide hormone|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of Notch signaling pathway|negative regulation of cell cycle|negative regulation of mitosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic camera-type eye morphogenesis|branching morphogenesis of an epithelial tube|mesenchymal cell differentiation|neuron projection morphogenesis|negative regulation of neurogenesis|cartilage development|embryonic skeletal joint morphogenesis|regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|branching involved in salivary gland morphogenesis|mesenchyme development|negative regulation of cell death|negative regulation of prostatic bud formation|regulation of branching involved in prostate gland morphogenesis|monocyte aggregation|cellular response to hypoxia|negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|negative regulation of glomerular mesangial cell proliferation|metanephric mesenchyme morphogenesis|nephrogenic mesenchyme morphogenesis|metanephric mesenchymal cell proliferation involved in metanephros development|positive regulation of dendrite development|positive regulation of hyaluranon cable assembly|regulation of removal of superoxide radicals|",cytokine activity|protein binding|protein binding|growth factor activity|heparin binding|,10,-0.4,0.345,10,-1.4,2.33,-0.8,1.99,0.287,-8,2.3
ENSMUSG00000031103,ELF4,E74-like factor 4 (ets domain transcription factor),nucleus|PML body|,"natural killer cell proliferation|NK T cell proliferation|transcription from RNA polymerase II promoter|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protein binding|,10,-1.9,2,10,-1,0.367,-1.7,1.99,0.287,-5.7,1.5
ENSMUSG00000031535,DKK4,dickkopf WNT signaling pathway inhibitor 4,cellular_component|extracellular region|,multicellular organismal development|Wnt signaling pathway|negative regulation of Wnt signaling pathway|,molecular_function|,10,-0.9,0.885,10,-1,1.26,-1,1.98,0.289,-4,1.5
ENSMUSG00000025265,FGD1,"FYVE, RhoGEF and PH domain containing 1",ruffle|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|lamellipodium|,cytoskeleton organization|signal transduction|small GTPase mediated signal transduction|multicellular organismal development|regulation of cell shape|organ morphogenesis|actin cytoskeleton organization|positive regulation of Rho GTPase activity|positive regulation of apoptotic process|regulation of Cdc42 GTPase activity|positive regulation of GTPase activity|filopodium assembly|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|small GTPase binding|metal ion binding|,1,-4.1,2.28,1,-1.3,0.233,-3.9,1.98,0.289,-8,0.9
ENSMUSG00000034156,BZRAP1,benzodiazepine receptor (peripheral) associated protein 1,cytoplasm|mitochondrion|,biological_process|,protein binding|benzodiazepine receptor binding|,0,0,0,2,2.5,2.1,2.5,1.98,0.289,-1.2,5
ENSMUSG00000020894,VAMP2,vesicle-associated membrane protein 2 (synaptobrevin 2),plasma membrane|integral component of plasma membrane|synaptic vesicle|membrane|cell junction|clathrin-coated vesicle|endocytic vesicle membrane|secretory granule membrane|synaptic vesicle membrane|SNARE complex|neuron projection terminus|clathrin-sculpted glutamate transport vesicle membrane|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|extracellular vesicular exosome|clathrin-sculpted monoamine transport vesicle membrane|,energy reserve metabolic process|post-Golgi vesicle-mediated transport|synaptic transmission|neurotransmitter secretion|glutamate secretion|cellular protein metabolic process|small molecule metabolic process|regulation of insulin secretion|membrane organization|,protein binding|,10,-1.7,1.63,10,-0.9,0.743,-1.2,1.98,0.289,-5.6,4
ENSMUSG00000024526,CIDEA,cell death-inducing DFFA-like effector a,nucleus|cytoplasm|mitochondrion|mitochondrial envelope|lipid particle|,"temperature homeostasis|apoptotic DNA fragmentation|transcription, DNA-templated|regulation of transcription, DNA-templated|lipid metabolic process|cell death|positive regulation of sequestering of triglyceride|lipid storage|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|response to stilbenoid|regulation of apoptotic process|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of lipid catabolic process|negative regulation of execution phase of apoptosis|regulation of apoptotic DNA fragmentation|",protein homodimerization activity|,10,-1.2,0.127,10,3.9,4.04,3.7,1.98,0.289,-2,8
ENSMUSG00000054256,MSI1,musashi RNA-binding protein 1,nucleus|cytoplasm|polysome|,nervous system development|response to hormone|epithelial cell differentiation|,nucleotide binding|RNA binding|poly(U) RNA binding|poly(A) RNA binding|,10,2.3,2.15,10,-0.5,0.236,-1.4,1.98,0.289,-5.4,4.7
ENSMUSG00000019923,ZWINT,ZW10 interacting kinetochore protein,kinetochore|condensed chromosome kinetochore|nucleus|cytoplasm|cytosol|dendrite|,mitotic sister chromatid segregation|mitotic cell cycle|cell cycle|spindle organization|mitotic cell cycle checkpoint|phosphatidylinositol-mediated signaling|establishment of localization in cell|,protein binding|protein N-terminus binding|,10,1.2,1.03,10,-2,2.05,1.6,1.98,0.289,-4.3,4.4
ENSMUSG00000021945,ZMYM2,"zinc finger, MYM-type 2",cytosol|PML body|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",zinc ion binding|ubiquitin conjugating enzyme binding|,10,-1.1,0.762,10,-2,1.77,-1.9,1.98,0.289,-8.3,3.7
ENSMUSG00000020275,REL,v-rel avian reticuloendotheliosis viral oncogene homolog,nucleoplasm|transcription factor complex|cytosol|,"cytokine production|transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of interleukin-12 biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|negative regulation of neuron death|",RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|protein binding|,10,-2.6,2.95,10,-0.6,0.608,-1.3,1.97,0.29,-7.7,1.8
ENSMUSG00000031885,CBFB,"core-binding factor, beta subunit",cellular_component|nucleus|membrane|,osteoblast differentiation|transcription from RNA polymerase II promoter|lymphocyte differentiation|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|cell maturation|definitive hemopoiesis|,DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|,10,0.3,0.069,10,-1.6,2.7,-1.2,1.97,0.29,-5.1,2.1
ENSMUSG00000058063,TRIM31,tripartite motif containing 31,mitochondrion|,protein ubiquitination|negative regulation of viral transcription|innate immune response|negative regulation of viral entry into host cell|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of viral release from host cell|,zinc ion binding|ligase activity|,1,2.4,2.09,0,0,0,2.4,1.97,0.29,-1.3,5
ENSMUSG00000020892,ALOXE3,arachidonate lipoxygenase 3,cytoplasm|,sphingolipid metabolic process|sensory perception of pain|arachidonic acid metabolic process|lipoxygenase pathway|peroxisome proliferator activated receptor signaling pathway|linoleic acid metabolic process|fat cell differentiation|ceramide biosynthetic process|hepoxilin biosynthetic process|oxidation-reduction process|establishment of skin barrier|,"iron ion binding|protein binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|hepoxilin A3 synthase activity|",10,3.6,0.68,10,-1.5,1.9,2.4,1.97,0.29,-4.9,6.9
ENSMUSG00000028268,GBP3,guanylate binding protein 3,cytoplasm|membrane|,GTP catabolic process|defense response to virus|,GTPase activity|protein binding|GTP binding|,1,2.4,2.09,0,0,0,2.4,1.97,0.29,-1.3,5
ENSMUSG00000071151,GM4799,predicted gene 4799,None,None,None,1,0,0,1,-3.1,2.53,-3.1,1.96,0.292,-6,1.1
ENSMUSG00000032185,CARM1,coactivator-associated arginine methyltransferase 1,nucleus|nucleoplasm|cytoplasm|cytosol|cytosol|,"regulation of growth plate cartilage chondrocyte proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation|pathogenesis|viral process|histone methylation|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|intracellular estrogen receptor signaling pathway|negative regulation of protein binding|regulation of intracellular estrogen receptor signaling pathway|histone H3-R2 methylation|histone H3-R17 methylation|cellular lipid metabolic process|small molecule metabolic process|positive regulation of fat cell differentiation|response to cAMP|endochondral bone morphogenesis|",transcription coactivator activity|protein binding|beta-catenin binding|protein methyltransferase activity|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity (H3-R17 specific)|histone methyltransferase activity|protein homodimerization activity|transcription regulatory region DNA binding|lysine-acetylated histone binding|,9,-2,0.209,10,-1.4,1.98,-1.6,1.96,0.292,-7.5,1.9
ENSMUSG00000024019,CMTR1,cap methyltransferase 1,nucleus|cytoplasm|,7-methylguanosine mRNA capping|7-methylguanosine mRNA capping|mRNA methylation|cap1 mRNA methylation|,nucleic acid binding|mRNA (nucleoside-2'-O-)-methyltransferase activity|,0,0,0,1,2.7,2.08,2.7,1.96,0.292,-1.3,5
ENSMUSG00000048483,ZDHHC22,"zinc finger, DHHC-type containing 22",endoplasmic reticulum|Golgi apparatus|integral component of membrane|,protein palmitoylation|protein localization to plasma membrane|,zinc ion binding|protein-cysteine S-palmitoyltransferase activity|,0,0,0,1,2.7,2.08,2.7,1.96,0.292,-1.3,5
ENSMUSG00000020431,ADCY1,adenylate cyclase 1 (brain),nucleus|plasma membrane|plasma membrane|integral component of membrane|extracellular vesicular exosome|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|axonogenesis|long-term memory|circadian rhythm|fibroblast growth factor receptor signaling pathway|response to lithium ion|activation of protein kinase A activity|intracellular signal transduction|response to drug|regulation of circadian rhythm|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,calmodulin binding|ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding|,10,-0.6,0.256,10,-2.3,2.62,-1.2,1.96,0.292,-5.6,1
ENSMUSG00000034522,ZFP395,zinc finger protein 395,nucleus|cytoplasm|,regulation of transcription from RNA polymerase II promoter|,DNA binding|,1,-3.7,2.08,0,0,0,-3.7,1.96,0.292,-7,1.1
ENSMUSG00000061374,FIZ1,FLT3-interacting zinc finger 1,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",nucleic acid binding|protein kinase binding|receptor tyrosine kinase binding|metal ion binding|,10,2.1,3.82,10,-0.8,0.623,1.4,1.95,0.293,-2.4,5.6
ENSMUSG00000053216,BTN2A2,"butyrophilin, subfamily 2, member A2",integral component of membrane|extracellular vesicular exosome|,negative regulation of cellular metabolic process|negative regulation of activated T cell proliferation|negative regulation of cytokine secretion|,None,0,0,0,1,-2.9,2.08,-2.9,1.95,0.293,-5,1.3
ENSMUSG00000006386,TEK,"TEK tyrosine kinase, endothelial",stress fiber|extracellular region|cytoplasm|actin filament|plasma membrane|integral component of plasma membrane|microvillus|cell-cell junction|focal adhesion|basal plasma membrane|cell surface|basolateral plasma membrane|apical plasma membrane|membrane raft|,angiogenesis|response to hypoxia|positive regulation of protein phosphorylation|positive regulation of protein phosphorylation|endothelial cell proliferation|positive regulation of endothelial cell proliferation|endochondral ossification|sprouting angiogenesis|cell-matrix adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|heart development|blood coagulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|single organismal cell-cell adhesion|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|organ regeneration|regulation of establishment or maintenance of cell polarity|positive regulation of peptidyl-serine phosphorylation|substrate adhesion-dependent cell spreading|intracellular signal transduction|negative regulation of apoptotic process|regulation of vascular permeability|response to peptide hormone|positive regulation of phosphatidylinositol 3-kinase activity|response to estrogen|positive regulation of angiogenesis|positive regulation of angiogenesis|protein autophosphorylation|Tie signaling pathway|negative regulation of inflammatory response|leukocyte migration|protein oligomerization|response to cAMP|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|positive regulation of protein kinase B signaling|definitive hemopoiesis|heart trabecula formation|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of intracellular signal transduction|positive regulation of actin cytoskeleton reorganization|regulation of endothelial cell apoptotic process|negative regulation of endothelial cell apoptotic process|,protein kinase activity|protein tyrosine kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|receptor activity|protein binding|ATP binding|growth factor binding|,10,2.1,2.49,10,-1.2,1.01,-1.2,1.95,0.293,-7.3,5.6
ENSMUSG00000031540,KAT6A,K(lysine) acetyltransferase 6A,nucleosome|nucleus|nucleoplasm|Golgi apparatus|PML body|MOZ/MORF histone acetyltransferase complex|,"heart morphogenesis|DNA packaging|chromatin organization|nucleosome assembly|transcription, DNA-templated|protein acetylation|histone acetylation|myeloid cell differentiation|somatic stem cell maintenance|embryonic hemopoiesis|aorta morphogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|histone H3 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|face morphogenesis|cellular senescence|",DNA binding|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|transcription factor binding|zinc ion binding|acetyltransferase activity|,9,-5.9,4.93,10,-0.5,0.165,-5.9,1.95,0.293,-11.8,1.3
ENSMUSG00000027349,FAM98B,"family with sequence similarity 98, member B",tRNA-splicing ligase complex|,None,poly(A) RNA binding|,0,0,0,1,-2.9,2.08,-2.9,1.95,0.293,-5,1.3
ENSMUSG00000056820,TSNAX,translin-associated factor X,nucleus|Golgi apparatus|perinuclear region of cytoplasm|,multicellular organismal development|spermatogenesis|protein transport|cell differentiation|,DNA binding|protein transporter activity|A2A adenosine receptor binding|protein complex binding|sequence-specific DNA binding|poly(A) RNA binding|metal ion binding|,1,-5.2,2.7,1,0.1,0.00405,-5.1,1.94,0.294,-10,0.8
ENSMUSG00000029380,CXCL1,"chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)",extracellular region|extracellular space|,chemotaxis|inflammatory response|immune response|signal transduction|G-protein coupled receptor signaling pathway|nervous system development|cell proliferation|negative regulation of cell proliferation|actin cytoskeleton organization|intracellular signal transduction|positive regulation of catalytic activity|cell chemotaxis|cell chemotaxis|,receptor binding|chemokine activity|enzyme activator activity|growth factor activity|,10,1.8,0.899,10,-1.3,2.16,-1.1,1.94,0.294,-4.3,3.5
ENSMUSG00000042751,NMNAT2,nicotinamide nucleotide adenylyltransferase 2,Golgi membrane|late endosome|Golgi apparatus|trans-Golgi network|synapse|,vitamin metabolic process|water-soluble vitamin metabolic process|NAD biosynthetic process|NAD biosynthetic process|NAD metabolic process|small molecule metabolic process|,nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|,10,1.4,1.27,10,1.5,0.814,1.5,1.94,0.294,-2.2,6
ENSMUSG00000031398,PLXNA3,plexin A3,semaphorin receptor complex|intracellular|plasma membrane|membrane|integral component of membrane|,multicellular organismal development|axon guidance|hippocampus development|pyramidal neuron development|negative regulation of axon extension involved in axon guidance|negative chemotaxis|positive regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|,transmembrane signaling receptor activity|protein binding|semaphorin receptor activity|,1,-5,2.68,1,0,0,-4.9,1.93,0.295,-10,0.8
ENSMUSG00000075031,HIST1H2BB,"histone cluster 1, H2bb",nucleosome|nucleus|nucleoplasm|,chromatin organization|nucleosome assembly|,DNA binding|protein binding|protein heterodimerization activity|,1,-4.7,2.53,1,-0.5,0.0604,-4.5,1.93,0.295,-9,0.8
ENSMUSG00000079019,INSL3,insulin-like 3 (Leydig cell),extracellular region|extracellular space|perinuclear region of cytoplasm|,oocyte maturation|in utero embryonic development|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|cell-cell signaling|spermatogenesis|positive regulation of cell proliferation|negative regulation of cell proliferation|male gonad development|positive regulation of cAMP biosynthetic process|negative regulation of apoptotic process|,G-protein coupled receptor binding|protease binding|receptor binding|insulin receptor binding|hormone activity|,10,-2.2,0.958,10,-5.4,2.21,-1,1.93,0.295,-9.6,2.2
ENSMUSG00000004535,TAX1BP1,Tax1 (human T-cell leukemia virus type I) binding protein 1,cytosol|,apoptotic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of apoptotic process|innate immune response|,protein binding|kinase binding|,10,-3.3,3.5,10,0,0,-1.7,1.93,0.295,-9.5,2.6
ENSMUSG00000022997,WNT1,"wingless-type MMTV integration site family, member 1",extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|,"embryonic axis specification|branching involved in ureteric bud morphogenesis|positive regulation of protein phosphorylation|cell-cell signaling|myoblast fusion|positive regulation of cell proliferation|positive regulation of cell proliferation|response to wounding|positive regulation of lamellipodium assembly|negative regulation of cell-substrate adhesion|Wnt signaling pathway|spinal cord association neuron differentiation|diencephalon development|central nervous system morphogenesis|cerebellum formation|forebrain anterior/posterior pattern specification|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|neuron differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|midbrain development|organ regeneration|T cell differentiation in thymus|inner ear morphogenesis|signal transduction in response to DNA damage|positive regulation of insulin-like growth factor receptor signaling pathway|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|neuron fate determination|positive regulation of sequence-specific DNA binding transcription factor activity|Spemann organizer formation|canonical Wnt signaling pathway|bone development|positive regulation of dermatome development|hepatocyte differentiation|cellular response to peptide hormone stimulus|hematopoietic stem cell proliferation|negative regulation of cell aging|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|",frizzled binding|frizzled binding|cytokine activity|protein domain specific binding|transcription regulatory region DNA binding|receptor agonist activity|,10,-1.1,0.71,10,-1,1.37,-1,1.93,0.295,-4.5,4.5
ENSMUSG00000029223,UCHL1,ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase),nucleus|cytoplasm|cytoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|axon|neuronal cell body|extracellular vesicular exosome|,response to ischemia|ubiquitin-dependent protein catabolic process|axon target recognition|adult walking behavior|cell death|cell proliferation|protein deubiquitination|sensory perception of pain|axon transport of mitochondrion|eating behavior|negative regulation of MAP kinase activity|muscle fiber development|neuromuscular process|,cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|protein binding|omega peptidase activity|ligase activity|alpha-2A adrenergic receptor binding|ubiquitin binding|,8,-2.4,1.76,9,-5.4,1.37,-3.2,1.93,0.295,-9.7,3.6
ENSMUSG00000024851,PITPNM1,"phosphatidylinositol transfer protein, membrane-associated 1",endoplasmic reticulum membrane|lipid particle|membrane|midbody|cleavage furrow|Golgi cisterna membrane|,lipid metabolic process|brain development|phototransduction|protein transport|phospholipid transport|,phosphatidylinositol transporter activity|metal ion binding|,0,0,0,1,2.7,2.05,2.7,1.93,0.295,-1.3,5
ENSMUSG00000041203,2310036O22RIK,RIKEN cDNA 2310036O22 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,2.7,2.05,2.7,1.93,0.295,-1.3,5
ENSMUSG00000029320,1700016H13RIK,RIKEN cDNA 1700016H13 gene,cellular_component|,biological_process|,molecular_function|,2,-2.5,2.05,0,0,0,-2.5,1.93,0.295,-5,1.3
ENSMUSG00000059552,TRP53,transformation related protein 53,chromatin|chromatin|nuclear chromatin|intracellular|nucleus|nucleus|nucleoplasm|replication fork|transcription factor complex|transcription factor complex|transcription factor TFIID complex|nucleolus|cytoplasm|cytoplasm|mitochondrion|mitochondrion|mitochondrion|mitochondrion|mitochondrial matrix|endoplasmic reticulum|cytosol|cytosol|nuclear matrix|nuclear body|PML body|protein complex|,"protein import into nucleus, translocation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|DNA strand renaturation|in utero embryonic development|somitogenesis|release of cytochrome c from mitochondria|release of cytochrome c from mitochondria|T cell proliferation involved in immune response|B cell lineage commitment|T cell lineage commitment|positive regulation of leukocyte migration|response to ischemia|nucleotide-excision repair|double-strand break repair|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|protein complex assembly|apoptotic process|apoptotic process|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|response to oxidative stress|response to oxidative stress|ER overload response|cell cycle|cell cycle arrest|transforming growth factor beta receptor signaling pathway|multicellular organismal development|gastrulation|negative regulation of neuroblast proliferation|central nervous system development|cell aging|cell aging|protein localization|negative regulation of DNA replication|negative regulation of DNA replication|negative regulation of cell proliferation|negative regulation of cell proliferation|determination of adult lifespan|rRNA transcription|response to UV|response to UV|response to salt stress|embryo development ending in birth or egg hatching|response to X-ray|response to gamma radiation|response to gamma radiation|response to gamma radiation|positive regulation of cardiac muscle cell apoptotic process|programmed cell death|cerebellum development|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|DNA damage response, signal transduction by p53 class mediator|DNA damage response, signal transduction by p53 class mediator|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of histone deacetylation|chromatin assembly|mitotic G1 DNA damage checkpoint|mitotic G1 DNA damage checkpoint|positive regulation of protein oligomerization|T cell differentiation in thymus|regulation of tissue remodeling|cellular protein localization|cellular response to UV|multicellular organism growth|positive regulation of mitochondrial membrane permeability|regulation of cell proliferation|regulation of cell proliferation|cellular response to glucose starvation|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of fibroblast proliferation|negative regulation of fibroblast proliferation|embryonic organ development|negative regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of catalytic activity|protein tetramerization|chromosome organization|neuron apoptotic process|neuron apoptotic process|regulation of intracellular pH|regulation of cell cycle|regulation of cell cycle|regulation of thymocyte apoptotic process|positive regulation of thymocyte apoptotic process|necroptotic process|positive regulation of cell cycle arrest|cellular response to ionizing radiation|cellular response to ionizing radiation|mitotic cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator|intrinsic apoptotic signaling pathway by p53 class mediator|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of release of cytochrome c from mitochondria|positive regulation of cell aging|replicative senescence|oxidative stress-induced premature senescence|oligodendrocyte apoptotic process|negative regulation of macromitophagy|regulation of mitochondrial membrane permeability involved in apoptotic process|negative regulation of DNA biosynthetic process|negative regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|positive regulation of intrinsic apoptotic signaling pathway|",RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding|transcription cofactor binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protease binding|p53 binding|DNA binding|DNA binding|chromatin binding|chromatin binding|damaged DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|copper ion binding|protein binding|ATP binding|protein C-terminus binding|transcription factor binding|enzyme binding|protein kinase binding|protein phosphatase binding|receptor tyrosine kinase binding|ubiquitin protein ligase binding|histone deacetylase regulator activity|histone acetyltransferase binding|identical protein binding|sequence-specific DNA binding|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding|protein heterodimerization activity|protein N-terminus binding|chaperone binding|protein phosphatase 2A binding|MDM2/MDM4 family protein binding|,10,1,2.15,10,0.4,0.166,0.8,1.93,0.295,-1.1,3.4
ENSMUSG00000027233,PATL2,protein associated with topoisomerase II homolog 2 (yeast),cytoplasmic mRNA processing body|nucleus|cytoplasm|ribonucleoprotein complex|,negative regulation of cytoplasmic mRNA processing body assembly|negative regulation of translation|,RNA binding|protein binding|,1,2.3,2.05,0,0,0,2.3,1.93,0.295,-1.3,5
ENSMUSG00000039007,CPQ,carboxypeptidase Q,extracellular space|cytoplasm|lysosome|endoplasmic reticulum|Golgi apparatus|extracellular vesicular exosome|,proteolysis|thyroid hormone generation|tissue regeneration|peptide catabolic process|,carboxypeptidase activity|protein homodimerization activity|metal ion binding|metallodipeptidase activity|,0,0,0,1,-2.9,2.04,-2.9,1.92,0.296,-5,1.3
ENSMUSG00000032446,EOMES,eomesodermin,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|endoderm formation|mesoderm formation|endodermal cell fate specification|trophectodermal cell differentiation|CD8-positive, alpha-beta T cell differentiation involved in immune response|transcription, DNA-templated|brain development|cardioblast differentiation|stem cell maintenance|olfactory bulb development|cerebral cortex regionalization|cerebral cortex neuron differentiation|interferon-gamma production|skeletal muscle cell differentiation|positive regulation of cell differentiation|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cell differentiation involved in embryonic placenta development|mesodermal to mesenchymal transition involved in gastrulation|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-5,2.68,1,0,0,-4.9,1.92,0.296,-10,0.8
ENSMUSG00000035242,OAZ1,ornithine decarboxylase antizyme 1,cytosol|,regulation of cellular amino acid metabolic process|polyamine biosynthetic process|cellular nitrogen compound metabolic process|negative regulation of catalytic activity|negative regulation of catalytic activity|negative regulation of catalytic activity|negative regulation of catalytic activity|small molecule metabolic process|positive regulation of protein catabolic process|positive regulation of protein catabolic process|,protein binding|ornithine decarboxylase inhibitor activity|ornithine decarboxylase inhibitor activity|,10,0,0,10,-1.9,3.21,-1.1,1.92,0.296,-5.1,7.7
ENSMUSG00000040276,PACSIN1,protein kinase C and casein kinase substrate in neurons 1,cytoplasm|cytosol|plasma membrane|cell junction|COPI-coated vesicle|cytoplasmic vesicle membrane|ruffle membrane|axon terminus|synapse|perinuclear region of cytoplasm|,actin filament organization|negative regulation of endocytosis|synaptic vesicle endocytosis|neuron projection morphogenesis|protein localization to membrane|establishment of protein localization to plasma membrane|membrane tubulation|positive regulation of dendrite development|,protein binding|phospholipid binding|cytoskeletal protein binding|,10,-0.4,0.0234,10,-4.1,2.2,-0.9,1.92,0.296,-9.6,1.5
ENSMUSG00000018707,DYNC1H1,"dynein, cytoplasmic 1, heavy chain 1",centrosome|cytosol|cytoplasmic dynein complex|microtubule|membrane|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|ATP catabolic process|transport|microtubule-based movement|mitotic spindle organization|cell death|antigen processing and presentation of exogenous peptide antigen via MHC class II|cytoplasmic mRNA processing body assembly|stress granule assembly|,microtubule motor activity|protein binding|ATP binding|ATPase activity|poly(A) RNA binding|,10,1.9,2.72,8,0.2,0.0519,1.7,1.91,0.298,-5.2,4.8
ENSMUSG00000026510,TRP53BP2,transformation related protein 53 binding protein 2,nucleus|cytoplasm|perinuclear region of cytoplasm|,apoptotic process|cell cycle|central nervous system development|heart development|embryo development ending in birth or egg hatching|response to ionizing radiation|intrinsic apoptotic signaling pathway by p53 class mediator|,SH3 domain binding|identical protein binding|NF-kappaB binding|,10,7.6,5.19,9,-0.9,0.534,7.6,1.91,0.298,-6,16
ENSMUSG00000031776,ARL2BP,ADP-ribosylation factor-like 2 binding protein,nucleus|mitochondrial intermembrane space|centrosome|spindle|cilium|midbody|,signal transduction|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of catalytic activity|maintenance of protein location in nucleus|regulation of RNA biosynthetic process|,transcription coactivator activity|small GTPase regulator activity|protein binding|,9,4.5,2.45,10,-1.6,1.85,-1.3,1.91,0.298,-4.4,8.3
ENSMUSG00000038872,ZFHX3,zinc finger homeobox 3,nucleus|transcription factor complex|mitochondrion|,"negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cell cycle arrest|brain development|muscle organ development|negative regulation of myoblast differentiation|positive regulation of myoblast differentiation|regulation of neuron differentiation|negative regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|zinc ion binding|enzyme binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,1.3,0.938,10,2.5,1.46,1.5,1.91,0.298,-3.9,5.8
ENSMUSG00000041438,CIRH1A,"cirrhosis, autosomal recessive 1A (cirhin)",nucleolus|t-UTP complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|maturation of SSU-rRNA|",protein binding|poly(A) RNA binding|,4,-4.2,3.58,4,0.3,0.0318,-4.1,1.91,0.298,-9,1.1
ENSMUSG00000005907,PEX1,peroxisomal biogenesis factor 1,cytoplasm|peroxisome|peroxisomal membrane|cytosol|intracellular membrane-bounded organelle|,ATP catabolic process|ATP catabolic process|protein targeting to peroxisome|peroxisome organization|protein import into peroxisome matrix|microtubule-based peroxisome localization|,"protein binding|ATP binding|protein C-terminus binding|protein complex binding|ATPase activity, coupled|",0,0,0,2,2.6,2.02,2.6,1.9,0.299,-1.3,5
ENSMUSG00000022540,ROGDI,rogdi homolog (Drosophila),intracellular|nuclear envelope|,positive regulation of cell proliferation|hemopoiesis|,None,9,-3.6,1.19,10,-1,1.12,-1.1,1.9,0.299,-10.9,5.5
ENSMUSG00000026803,TTF1,"transcription termination factor, RNA polymerase I",nucleus|nucleus|nucleoplasm|nucleolus|cytoplasm|plasma membrane|,"chromatin remodeling|DNA-templated transcription, termination|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|termination of RNA polymerase I transcription|negative regulation of DNA replication|gene expression|",DNA binding|chromatin binding|,7,-5.4,1.65,8,-2.3,2.36,-2.7,1.9,0.299,-10.7,2.7
ENSMUSG00000030057,CNBP,"CCHC-type zinc finger, nucleic acid binding protein",nucleus|endoplasmic reticulum|cytosol|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cholesterol biosynthetic process|positive regulation of cell proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",single-stranded DNA binding|sequence-specific DNA binding transcription factor activity|single-stranded RNA binding|protein binding|zinc ion binding|poly(A) RNA binding|,10,-0.5,0.316,10,-1.1,2.01,-0.8,1.89,0.301,-4.4,1.6
ENSMUSG00000026639,LAMB3,"laminin, beta 3",extracellular region|laminin-5 complex|,cell adhesion|epidermis development|extracellular matrix disassembly|extracellular matrix organization|hemidesmosome assembly|cell junction assembly|brown fat cell differentiation|,structural molecule activity|protein binding|protein complex binding|,10,-2.1,2.84,9,-0.4,0.245,-1.9,1.89,0.301,-4.9,3.7
ENSMUSG00000019990,PDE7B,phosphodiesterase 7B,cytosol|,cAMP catabolic process|signal transduction|synaptic transmission|,"3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|",0,0,0,1,2.7,2.01,2.7,1.89,0.301,-1.3,5
ENSMUSG00000025408,DDIT3,DNA-damage-inducible transcript 3,nucleus|nucleoplasm|late endosome|,"blood vessel maturation|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|ER overload response|response to unfolded protein|activation of signaling protein activity involved in unfolded protein response|cell cycle arrest|Wnt signaling pathway|endoplasmic reticulum unfolded protein response|positive regulation of interleukin-8 production|response to endoplasmic reticulum stress|response to starvation|mRNA transcription from RNA polymerase II promoter|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of neuron apoptotic process|regulation of DNA-templated transcription in response to stress|cellular protein metabolic process|regulation of transcription involved in anterior/posterior axis specification|cell redox homeostasis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of canonical Wnt signaling pathway|negative regulation of determination of dorsal identity|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|transcription factor binding|sequence-specific DNA binding|,9,2.5,2.49,9,-0.8,0.467,2.5,1.89,0.301,-2,7.1
ENSMUSG00000031441,ATP11A,"ATPase, class VI, type 11A",lysosomal membrane|early endosome|endoplasmic reticulum|plasma membrane|membrane|integral component of membrane|recycling endosome|,cation transport|metabolic process|phospholipid translocation|,magnesium ion binding|phospholipid-translocating ATPase activity|protein binding|ATP binding|cation-transporting ATPase activity|,10,-4.7,3.92,10,-0.5,0.13,-2.2,1.89,0.301,-8.7,1.7
ENSMUSG00000098207,ARL14,ADP-ribosylation factor-like 14,cytoplasmic membrane-bounded vesicle|,small GTPase mediated signal transduction|,protein binding|GTP binding|,0,0,0,1,2.7,2.01,2.7,1.89,0.301,-1.3,5
ENSMUSG00000038619,ENSA,endosulfine alpha,nucleoplasm|cytoplasm|,G2/M transition of mitotic cell cycle|mitotic cell cycle|transport|mitotic nuclear division|response to nutrient|response to glucose|negative regulation of catalytic activity|negative regulation of catalytic activity|regulation of catalytic activity|regulation of insulin secretion|,protein phosphatase inhibitor activity|receptor binding|ion channel inhibitor activity|protein phosphatase type 2A regulator activity|phosphatase inhibitor activity|potassium channel inhibitor activity|protein phosphatase 2A binding|,1,2.3,2,0,0,0,2.3,1.88,0.302,-1.3,5
ENSMUSG00000049971,GLT1D1,glycosyltransferase 1 domain containing 1,extracellular region|cytoplasm|,biosynthetic process|,"transferase activity, transferring glycosyl groups|",10,-0.6,0.201,10,-3.4,3.86,-1,1.88,0.302,-8.7,1.7
ENSMUSG00000056018,1700008F21RIK,RIKEN cDNA 1700008F21 gene,cellular_component|,biological_process|,molecular_function|,1,-3.6,2,0,0,0,-3.6,1.88,0.302,-7,1.2
ENSMUSG00000096168,TRAV5N-4,T cell receptor alpha variable 5N-4,None,None,None,5,3.9,3.25,4,0.4,0.228,3.7,1.88,0.302,-0.5,8.8
ENSMUSG00000047307,PCDHB13,protocadherin beta 13,plasma membrane|integral component of membrane|,homophilic cell adhesion|synaptic transmission|synapse assembly|calcium-dependent cell-cell adhesion|,calcium ion binding|,0,0,0,1,-2.9,2,-2.9,1.88,0.302,-5,1.3
ENSMUSG00000027620,RBM39,RNA binding motif protein 39,nucleus|nucleoplasm|microtubule organizing center|microtubule cytoskeleton|nuclear speck|,"transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|mRNA processing|RNA splicing|",nucleotide binding|protein binding|poly(A) RNA binding|,8,-4.1,1.12,9,3.3,4.28,3.1,1.88,0.302,-6.7,7.2
ENSMUSG00000056306,SERTM1,serine-rich and transmembrane domain containing 1,integral component of membrane|,None,None,1,2.3,2,0,0,0,2.3,1.88,0.302,-1.3,5
ENSMUSG00000063953,AMD2,S-adenosylmethionine decarboxylase 2,cytosol|,polyamine biosynthetic process|spermidine biosynthetic process|,adenosylmethionine decarboxylase activity|adenosylmethionine decarboxylase activity|lyase activity|carboxy-lyase activity|putrescine binding|,8,-6.4,4.32,8,-0.5,0.183,-4.6,1.88,0.302,-13,5.2
ENSMUSG00000063011,MSLN,mesothelin,extracellular space|Golgi apparatus|plasma membrane|cell surface|membrane|anchored component of membrane|,cell adhesion|pancreas development|,protein binding|,10,0.1,0.0152,10,-2.1,2.5,-2.3,1.88,0.302,-8.4,2.8
ENSMUSG00000096106,TRAV5D-4,T cell receptor alpha variable 5D-4,None,None,None,5,3.9,3.25,4,0.4,0.228,3.7,1.88,0.302,-0.5,8.8
ENSMUSG00000022565,PLEC,plectin,cytoplasm|cytosol|plasma membrane|focal adhesion|sarcoplasm|hemidesmosome|sarcolemma|costamere|intermediate filament cytoskeleton|extracellular vesicular exosome|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|extracellular matrix organization|hemidesmosome assembly|hemidesmosome assembly|cell junction assembly|,actin binding|protein binding|structural constituent of muscle|structural constituent of muscle|ankyrin binding|poly(A) RNA binding|,10,6.7,3.35,10,-1.4,2.02,-1.6,1.87,0.303,-8.3,12.5
ENSMUSG00000028565,NFIA,nuclear factor I/A,nucleus|nucleus|,"DNA replication|transcription, DNA-templated|regulation of transcription, DNA-templated|response to organic cyclic compound|viral genome replication|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription factor binding|,2,-2.7,1.99,0,0,0,-2.7,1.87,0.303,-6,1.2
ENSMUSG00000028104,POLR3GL,polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like,nuclear chromatin|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|,transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|gene expression|positive regulation of type I interferon production|innate immune response|,RNA polymerase III activity|,9,-1.9,1.05,9,-1.4,1.04,-1.8,1.87,0.303,-4.5,1.4
ENSMUSG00000047501,CLDN4,claudin 4,plasma membrane|integral component of plasma membrane|tight junction|tight junction|basal plasma membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|,signal transduction|female pregnancy|calcium-independent cell-cell adhesion|response to progesterone|establishment of skin barrier|,transmembrane signaling receptor activity|structural molecule activity|identical protein binding|,10,-3.2,3.6,9,-0.6,0.238,-2.8,1.87,0.303,-8,1.5
ENSMUSG00000021619,ATG10,autophagy related 10,intracellular|cytoplasm|,protein lipidation|protein lipidation|autophagy|protein transport|positive regulation of protein modification process|protein modification by small protein conjugation|autophagy in response to ER overload|,Atg12 ligase activity|Atg12 ligase activity|,10,0,0,10,-1.7,3.31,-1.2,1.87,0.303,-6.8,2.1
ENSMUSG00000024406,POU5F1,POU class 5 homeobox 1,nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|,"endodermal cell fate specification|blastocyst development|BMP signaling pathway involved in heart induction|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|response to wounding|anatomical structure morphogenesis|regulation of asymmetric cell division|regulation of gene expression|somatic stem cell maintenance|somatic stem cell maintenance|positive regulation of catenin import into nucleus|mRNA transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of SMAD protein import into nucleus|cell fate commitment involved in formation of primary germ layer|cardiac cell fate determination|negative regulation of gene silencing by miRNA|regulation of heart induction by regulation of canonical Wnt signaling pathway|regulation of methylation-dependent chromatin silencing|",sequence-specific DNA binding RNA polymerase II transcription factor activity|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|ubiquitin protein ligase binding|miRNA binding|sequence-specific DNA binding|transcription regulatory region DNA binding|poly(A) RNA binding|,7,2.8,0.407,8,-2.8,2.14,-2.1,1.87,0.303,-6.6,4.6
ENSMUSG00000020644,ID2,"inhibitor of DNA binding 2, dominant negative helix-loop-helix protein",chromatin|nucleus|cytoplasm|cytoplasm|centrosome|cytosol|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|metanephros development|natural killer cell differentiation|membranous septum morphogenesis|bundle of His development|multicellular organismal development|positive regulation of gene expression|negative regulation of gene expression|oligodendrocyte development|regulation of lipid metabolic process|olfactory bulb development|circadian regulation of gene expression|mammary gland epithelial cell proliferation|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|enucleate erythrocyte differentiation|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|locomotor rhythm|negative regulation of B cell differentiation|positive regulation of fat cell differentiation|positive regulation of erythrocyte differentiation|positive regulation of macrophage differentiation|negative regulation of neuron differentiation|negative regulation of osteoblast differentiation|positive regulation of blood pressure|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|cell maturation|Peyer's patch development|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|neuron fate commitment|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|adipose tissue development|mammary gland alveolus development|epithelial cell differentiation involved in mammary gland alveolus development|endodermal digestive tract morphogenesis|positive regulation of cell cycle arrest|cellular response to lithium ion|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|cellular senescence|regulation of G1/S transition of mitotic cell cycle|negative regulation of neural precursor cell proliferation|",protein binding|ion channel binding|protein dimerization activity|,9,4.5,0.659,10,1.8,2.54,2.6,1.87,0.303,-2.4,10
ENSMUSG00000032053,POU2AF1,POU class 2 associating factor 1,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|humoral immune response|",DNA binding|transcription cofactor activity|transcription coactivator activity|protein binding|,10,-1.8,0.511,10,-1.3,1.67,-1.5,1.86,0.305,-5.9,4.1
ENSMUSG00000026965,ANAPC2,anaphase promoting complex subunit 2,nucleoplasm|anaphase-promoting complex|cytosol|,regulation of cyclin-dependent protein serine/threonine kinase activity|mitotic cell cycle|ubiquitin-dependent protein catabolic process|mitotic nuclear division|mitotic spindle assembly checkpoint|cyclin catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of synaptic plasticity|positive regulation of axon extension|positive regulation of dendrite morphogenesis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|positive regulation of synapse maturation|,ubiquitin-protein transferase activity|ubiquitin protein ligase binding|,10,-2.7,3.79,9,0.5,0.204,-2.5,1.86,0.305,-7.4,2.9
ENSMUSG00000058301,UPF1,UPF1 regulator of nonsense transcripts homolog (yeast),chromatin|cytoplasmic mRNA processing body|nucleus|cytoplasm|cytosol|exon-exon junction complex|supraspliceosomal complex|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process|ATP catabolic process|DNA replication|DNA repair|mRNA export from nucleus|regulation of translational termination|regulation of translational termination|dosage compensation by inactivation of X chromosome|gene expression|RNA metabolic process|mRNA metabolic process|histone mRNA catabolic process|",DNA binding|chromatin binding|RNA binding|ATP-dependent RNA helicase activity|helicase activity|protein binding|ATP binding|zinc ion binding|poly(A) RNA binding|,10,1.8,3.01,10,-3,2.65,-1.9,1.86,0.305,-6.8,5.5
ENSMUSG00000021417,ECI2,enoyl-CoA delta isomerase 2,nucleus|mitochondrion|peroxisomal matrix|peroxisomal matrix|membrane|intracellular membrane-bounded organelle|,metabolic process|fatty acid catabolic process|,fatty-acyl-CoA binding|dodecenoyl-CoA delta-isomerase activity|dodecenoyl-CoA delta-isomerase activity|receptor binding|,10,0.5,0.229,10,-2,2.71,-1.3,1.86,0.305,-5.1,4.1
ENSMUSG00000079102,DAB2,"Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)",nucleolus|lysosomal membrane|plasma membrane|plasma membrane|coated pit|apical plasma membrane|clathrin coat of coated pit|clathrin-coated vesicle membrane|intracellular membrane-bounded organelle|transforming growth factor beta receptor homodimeric complex|extracellular vesicular exosome|,"cell morphogenesis involved in differentiation|in utero embryonic development|positive regulation of receptor recycling|positive regulation of protein phosphorylation|receptor-mediated endocytosis|pinocytosis|apoptotic process|activation of JUN kinase activity|endoderm development|excretion|cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|protein transport|Wnt signaling pathway|myeloid cell differentiation|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of apoptotic process|positive regulation of endocytosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|clathrin coat assembly|positive regulation of SMAD protein import into nucleus|negative regulation of androgen receptor signaling pathway|membrane organization|cellular response to transforming growth factor beta stimulus|negative regulation of canonical Wnt signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of Wnt signaling pathway, planar cell polarity pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of early endosome to late endosome transport|positive regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|","integrin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|protein C-terminus binding|AP-2 adaptor complex binding|clathrin adaptor activity|cargo receptor activity|SMAD binding|",10,7.1,5.11,10,0.5,0.523,7.1,1.86,0.305,-1.1,14.7
ENSMUSG00000055707,KLHL26,kelch-like family member 26,None,None,None,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000034593,MYO5A,"myosin VA (heavy chain 12, myoxin)",ruffle|photoreceptor outer segment|cytoplasm|Golgi apparatus|intermediate filament|membrane|myosin complex|growth cone|insulin-responsive compartment|microtubule plus-end|melanosome|actomyosin|neuron projection|neuronal cell body|,"transport|exocytosis|synaptic transmission|visual perception|protein transport|vesicle-mediated transport|actin filament-based movement|insulin secretion|melanocyte differentiation|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|locomotion involved in locomotory behavior|secretory granule localization|melanosome transport|cellular response to insulin stimulus|melanin biosynthetic process|odontogenesis|myelination|anagen|long-chain fatty acid biosynthetic process|cellular protein metabolic process|synapse organization|endoplasmic reticulum localization|membrane organization|protein localization to plasma membrane|",microfilament motor activity|actin binding|calcium ion binding|calmodulin binding|ATP binding|Rab GTPase binding|poly(A) RNA binding|,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000045994,B3GAT1,"beta-1,3-glucuronyltransferase 1",Golgi membrane|integral component of membrane|,carbohydrate metabolic process|protein glycosylation|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|small molecule metabolic process|,"UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding|",10,-3.6,1.77,10,-0.5,0.503,-3.5,1.85,0.306,-7.7,1.6
ENSMUSG00000021303,GNG4,"guanine nucleotide binding protein (G protein), gamma 4",heterotrimeric G-protein complex|plasma membrane|,energy reserve metabolic process|G-protein coupled receptor signaling pathway|synaptic transmission|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|small molecule metabolic process|cellular response to glucagon stimulus|,signal transducer activity|protein binding|,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000025465,ECHS1,"enoyl CoA hydratase, short chain, 1, mitochondrial",mitochondrion|mitochondrion|mitochondrial matrix|extracellular vesicular exosome|,fatty acid beta-oxidation|fatty acid beta-oxidation|cellular lipid metabolic process|small molecule metabolic process|,enoyl-CoA hydratase activity|protein binding|,9,1.3,1.88,9,1,0.144,1.2,1.85,0.306,-5.1,5
ENSMUSG00000066278,VPS37B,vacuolar protein sorting 37 homolog B (S. cerevisiae),ESCRT I complex|endosome membrane|midbody|late endosome membrane|extracellular vesicular exosome|,protein transport|viral process|endosomal transport|viral life cycle|virion assembly|viral protein processing|membrane organization|intracellular transport of virus|,protein binding|,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000057134,ADO,2-aminoethanethiol (cysteamine) dioxygenase,mitochondrion|,oxidation-reduction process|,metal ion binding|cysteamine dioxygenase activity|,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000020974,POLE2,"polymerase (DNA directed), epsilon 2, accessory subunit",nucleus|nucleoplasm|epsilon DNA polymerase complex|intracellular membrane-bounded organelle|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication|DNA replication initiation|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|telomere maintenance via semi-conservative replication|",DNA binding|DNA-directed DNA polymerase activity|,10,-4,1.14,10,-3.1,1.19,-3.8,1.85,0.306,-8.2,2.5
ENSMUSG00000057778,CYB5D2,cytochrome b5 domain containing 2,extracellular region|,nervous system development|,heme binding|,0,0,0,1,2.7,1.97,2.7,1.85,0.306,-1.4,5
ENSMUSG00000052572,DLG2,"discs, large homolog 2 (Drosophila)",plasma membrane|postsynaptic density|cell junction|juxtaparanode region of axon|postsynaptic membrane|,synaptic transmission|negative regulation of phosphatase activity|sensory perception of pain|nucleotide phosphorylation|,guanylate kinase activity|protein binding|,9,0,0,10,4.7,3.8,3,1.85,0.306,-4.1,11
ENSMUSG00000054051,ERCC6,excision repair cross-complementation group 6,nucleus|nucleoplasm|nucleoplasm|nucleolus|transcription elongation factor complex|,"response to superoxide|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|pyrimidine dimer repair|transcription from RNA polymerase II promoter|response to oxidative stress|activation of JNKK activity|activation of JUN kinase activity|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|response to toxic substance|response to X-ray|response to UV-B|response to gamma radiation|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|multicellular organism growth|photoreceptor cell maintenance|",DNA binding|chromatin binding|protein binding|ATP binding|protein C-terminus binding|DNA-dependent ATPase activity|protein complex binding|protein N-terminus binding|,9,-2.7,1.48,9,-1.1,1.54,-2.3,1.84,0.308,-7.6,4.1
ENSMUSG00000022914,BRWD1,bromodomain and WD repeat domain containing 1,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cytoskeleton organization|regulation of cell shape|",molecular_function|,1,2.3,1.96,0,0,0,2.3,1.84,0.308,-1.4,5
ENSMUSG00000027272,UBR1,ubiquitin protein ligase E3 component n-recognin 1,ubiquitin ligase complex|proteasome complex|cytosol|,ubiquitin-dependent protein catabolic process|protein ubiquitination|negative regulation of TOR signaling|cellular response to leucine|,ubiquitin-protein transferase activity|zinc ion binding|ligase activity|leucine binding|,9,6.8,3.41,9,1.9,1.87,6.6,1.84,0.308,-2.7,15
ENSMUSG00000055733,NAP1L3,nucleosome assembly protein 1-like 3,nucleus|,nucleosome assembly|,None,10,-1.2,0.284,10,-1.8,1.8,-1.5,1.84,0.308,-4.7,4.4
ENSMUSG00000026278,BOK,BCL2-related ovarian killer,nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial membrane|,apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|brain development|cell proliferation|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of apoptotic process|oligodendrocyte differentiation|neuron apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of execution phase of apoptosis|,protein binding|protein homodimerization activity|protein heterodimerization activity|BH domain binding|,10,-3.1,2.61,10,-0.8,0.618,-1.9,1.84,0.308,-7.5,1.1
ENSMUSG00000068394,CEP152,centrosomal protein 152kDa,nucleus|centrosome|cytosol|deuterosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|centriole replication|cell projection organization|centrosome duplication|de novo centriole assembly|,protein binding|protein kinase binding|,10,-1.5,1.45,10,-2,0.671,-1.8,1.84,0.308,-9.6,1.8
ENSMUSG00000018143,MAFK,v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K,nucleoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|blood coagulation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,-0.8,0.856,10,-0.8,1.13,-0.8,1.84,0.308,-10,4.6
ENSMUSG00000022369,MTBP,MDM2 binding protein,kinetochore|chromatin|,cell cycle arrest|traversing start control point of mitotic cell cycle|negative regulation of cell proliferation|protein localization to kinetochore|mitotic spindle checkpoint|,None,9,-1.7,0.988,9,4.4,4.76,4.3,1.83,0.309,-3.7,9.9
ENSMUSG00000095620,2010005H15RIK,RIKEN cDNA 2010005H15 gene,cornified envelope|extracellular space|nucleus|cytoplasm|extracellular vesicular exosome|,negative regulation of endopeptidase activity|,"protease binding|cysteine-type endopeptidase inhibitor activity|structural molecule activity|protein binding, bridging|",9,-5.4,3.05,9,1.5,1.37,1.3,1.83,0.309,-9.2,4
ENSMUSG00000030846,TIAL1,TIA1 cytotoxic granule-associated RNA binding protein-like 1,nucleus|cytoplasm|lysosome|cytoplasmic stress granule|extracellular vesicular exosome|,regulation of transcription from RNA polymerase II promoter|apoptotic process|defense response|germ cell development|positive regulation of cell proliferation|stem cell division|,nucleotide binding|RNA binding|AU-rich element binding|poly(A) RNA binding|,9,0.7,0.407,9,1.6,1.95,1.4,1.83,0.309,-5.3,5
ENSMUSG00000050989,SEPN1,"selenoprotein N, 1",endoplasmic reticulum membrane|,biological_process|,molecular_function|calcium ion binding|protein binding|,0,0,0,1,2.6,1.93,2.6,1.82,0.311,-1.4,5
ENSMUSG00000027315,SPINT1,"serine peptidase inhibitor, Kunitz type 1",extracellular region|extracellular space|membrane|extracellular vesicular exosome|,negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|extracellular matrix organization|branching involved in labyrinthine layer morphogenesis|placenta blood vessel development|,serine-type endopeptidase inhibitor activity|,0,0,0,1,2.6,1.93,2.6,1.82,0.311,-1.4,5
ENSMUSG00000063727,TNFRSF11B,"tumor necrosis factor receptor superfamily, member 11b",extracellular region|proteinaceous extracellular matrix|extracellular space|,skeletal system development|apoptotic process|signal transduction|response to nutrient|extracellular matrix organization|response to magnesium ion|negative regulation of odontogenesis of dentin-containing tooth|response to drug|response to estrogen|negative regulation of bone resorption|response to arsenic-containing substance|,receptor activity|cytokine activity|,10,-1.9,1.99,10,4.1,3.46,-1.6,1.82,0.311,-4.7,8.1
ENSMUSG00000045690,WDR89,WD repeat domain 89,None,None,None,8,1.5,0.759,10,1.4,1.22,1.4,1.82,0.311,-4.3,5.2
ENSMUSG00000043670,DIRAS1,"DIRAS family, GTP-binding RAS-like 1",plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|,GTPase activity|GTP binding|,10,-1.7,1.19,10,-2,0.83,-1.7,1.82,0.311,-5.9,5
ENSMUSG00000026646,SUV39H2,suppressor of variegation 3-9 homolog 2 (Drosophila),"chromosome, centromeric region|chromatin|nuclear heterochromatin|","chromatin assembly or disassembly|chromatin remodeling|transcription, DNA-templated|male meiosis|cell differentiation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|rhythmic process|",transcription regulatory region sequence-specific DNA binding|chromatin binding|protein binding|zinc ion binding|histone methyltransferase activity (H3-K9 specific)|,10,1.1,1.38,10,-5.5,1.59,0.9,1.81,0.313,-9.4,3.8
ENSMUSG00000063594,GNG8,"guanine nucleotide binding protein (G protein), gamma 8",heterotrimeric G-protein complex|plasma membrane|,energy reserve metabolic process|GTP catabolic process|G-protein coupled receptor signaling pathway|synaptic transmission|nervous system development|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|protein binding|,10,2.1,4.22,10,-0.7,0.656,1.6,1.81,0.313,-3.1,5.2
ENSMUSG00000019866,AIM1,absent in melanoma 1,cellular_component|,biological_process|,molecular_function|,10,0.6,0.672,10,-1.6,3.22,-1.5,1.81,0.313,-6,2.2
ENSMUSG00000029759,PON3,paraoxonase 3,extracellular space|intracellular membrane-bounded organelle|extracellular vesicular exosome|,response to external stimulus|phenylacetate catabolic process|dephosphorylation|aromatic compound catabolic process|coumarin catabolic process|carboxylic acid catabolic process|,"aryldialkylphosphatase activity|arylesterase activity|arylesterase activity|3,4-dihydrocoumarin hydrolase activity|protein homodimerization activity|metal ion binding|dihydrocoumarin hydrolase activity|",10,1.4,1.96,10,-1.3,1.37,1.2,1.81,0.313,-4.4,6.4
ENSMUSG00000029580,ACTB,"actin, beta",nuclear chromatin|extracellular space|nucleoplasm|cytoplasm|cytosol|cytoskeleton|postsynaptic density|membrane|axon|ribonucleoprotein complex|cortical cytoskeleton|NuA4 histone acetyltransferase complex|cytoplasmic ribonucleoprotein granule|protein complex|extracellular vesicular exosome|MLL5-L complex|blood microparticle|,retina homeostasis|chromatin organization|protein folding|cellular component movement|axon guidance|blood coagulation|substantia nigra development|cell junction assembly|adherens junction organization|Fc-gamma receptor signaling pathway involved in phagocytosis|ATP-dependent chromatin remodeling|cellular protein metabolic process|innate immune response|cell-cell junction organization|'de novo' posttranslational protein folding|membrane organization|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|structural constituent of cytoskeleton|protein binding|ATP binding|kinesin binding|protein kinase binding|Tat protein binding|nucleosomal DNA binding|nitric-oxide synthase binding|,9,-0.6,0.4,9,-1.4,1.87,-1.1,1.81,0.313,-5,1.1
ENSMUSG00000054069,6030452D12RIK,RIKEN cDNA 6030452D12 gene,cellular_component|,biological_process|,molecular_function|,1,-3.5,1.93,0,0,0,-3.5,1.81,0.313,-7,1.2
ENSMUSG00000028977,CASZ1,castor zinc finger 1,nucleus|cytoplasm|intracellular membrane-bounded organelle|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|",DNA binding|metal ion binding|,1,-5.7,2.57,1,-0.1,0.00499,-5.6,1.81,0.313,-11,0.8
ENSMUSG00000032410,XRN1,5'-3' exoribonuclease 1,cytoplasmic mRNA processing body|cytosol|membrane|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process|gene expression|RNA metabolic process|mRNA metabolic process|rRNA catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA surveillance|histone mRNA catabolic process|nucleic acid phosphodiester bond hydrolysis|",DNA binding|protein binding|5'-3' exonuclease activity|poly(A) RNA binding|,10,-0.9,2,10,-0.4,0.19,-0.8,1.81,0.313,-11.4,2
ENSMUSG00000040828,CATSPERD,catsper channel auxiliary subunit delta,plasma membrane|CatSper complex|ciliary membrane|sperm principal piece|,cilium or flagellum-dependent cell motility|multicellular organismal development|spermatogenesis|single fertilization|sperm motility|multicellular organism reproduction|sperm-egg recognition|sperm capacitation|,None,1,0.7,0.217,1,-3,2.36,-3,1.81,0.313,-6,1.3
ENSMUSG00000072772,GRCC10,"gene rich cluster, C10 gene",cellular_component|cytoplasm|,biological_process|,molecular_function|,0,0,0,2,1.8,1.92,1.8,1.8,0.314,-1.4,4
ENSMUSG00000079666,1700015F17RIK,RIKEN cDNA 1700015F17 gene,cellular_component|,biological_process|,molecular_function|,1,-3.5,1.92,0,0,0,-3.5,1.8,0.314,-7,1.2
ENSMUSG00000029823,LUC7L2,LUC7-like 2 (S. cerevisiae),U1 snRNP|nuclear speck|,mRNA splice site selection|,mRNA binding|protein binding|enzyme binding|poly(A) RNA binding|,1,-3.5,1.92,0,0,0,-3.5,1.8,0.314,-7,1.2
ENSMUSG00000035093,SECISBP2L,SECIS binding protein 2-like,None,None,poly(A) RNA binding|,1,-3.5,1.9,0,0,0,-3.5,1.79,0.316,-7,1.2
ENSMUSG00000025377,ENTHD2,ENTH domain containing 2,cytosol|cytoplasmic membrane-bounded vesicle|,None,None,2,2.4,1.91,0,0,0,2.4,1.79,0.316,-5.3,6
ENSMUSG00000075012,FJX1,four jointed box 1 (Drosophila),extracellular space|,None,None,7,-2.2,2.85,9,0.7,0.14,-2.1,1.79,0.316,-7.4,3.1
ENSMUSG00000021223,PAPLN,"papilin, proteoglycan-like sulfated glycoprotein",basement membrane|,proteolysis|negative regulation of endopeptidase activity|,metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding|,10,3.5,1.72,10,-1.1,1.32,-1.7,1.79,0.316,-6.3,6.3
ENSMUSG00000032396,DIS3L,DIS3 like exosome 3'-5' exoribonuclease,cytoplasmic exosome (RNase complex)|,"rRNA catabolic process|rRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|RNA phosphodiester bond hydrolysis, exonucleolytic|",3'-5'-exoribonuclease activity|3'-5'-exoribonuclease activity|RNA binding|protein binding|enzyme binding|,1,-3.5,1.91,0,0,0,-3.5,1.79,0.316,-7,1.2
ENSMUSG00000027777,SCHIP1,schwannomin interacting protein 1,cytoplasm|,biological_process|,protein binding|identical protein binding|,0,0,0,1,2.6,1.9,2.6,1.78,0.318,-1.4,5
ENSMUSG00000028454,PIGO,"phosphatidylinositol glycan anchor biosynthesis, class O",endoplasmic reticulum membrane|membrane|integral component of membrane|,C-terminal protein lipidation|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,molecular_function|transferase activity|,10,1.5,1.93,10,0.7,0.315,1.1,1.78,0.318,-7.4,4.7
ENSMUSG00000044813,SHB,Src homology 2 domain containing adaptor protein B,cytoplasm|plasma membrane|,angiogenesis|apoptotic process|signal transduction|positive regulation of signal transduction|hemopoiesis|cell differentiation|B cell proliferation|negative regulation of oocyte maturation|,glycoprotein binding|SH3/SH2 adaptor activity|protein binding|,0,0,0,1,2.6,1.9,2.6,1.78,0.318,-1.4,5
ENSMUSG00000024600,SLC27A6,"solute carrier family 27 (fatty acid transporter), member 6",plasma membrane|integral component of membrane|sarcolemma|,very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid transport|transmembrane transport|,nucleotide binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|,0,0,0,1,2.6,1.9,2.6,1.78,0.318,-1.4,5
ENSMUSG00000030796,TEAD2,TEA domain family member 2,nucleus|nucleoplasm|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|gene expression|hippo signaling|",DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|,10,-2.3,2.34,10,-0.7,0.132,-1.2,1.78,0.318,-5.1,1.9
ENSMUSG00000003872,LIN7B,lin-7 homolog B (C. elegans),tight junction|postsynaptic density|basolateral plasma membrane|neuron projection|postsynaptic membrane|,exocytosis|neurotransmitter secretion|protein transport|,protein domain specific binding|,10,-1.8,2.49,10,0,0,-1.7,1.78,0.318,-6.2,1.6
ENSMUSG00000029068,CCNL2,cyclin L2,nucleus|nuclear speck|,"regulation of cyclin-dependent protein serine/threonine kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|",protein kinase binding|,2,-2.3,1.81,2,-1.8,0.175,-2.1,1.78,0.318,-5,1.2
ENSMUSG00000042515,MUM1L1,melanoma associated antigen (mutated) 1-like 1,extracellular vesicular exosome|,None,None,10,-0.1,0.00216,10,2.5,2.99,1.7,1.77,0.319,-2,6
ENSMUSG00000032598,NCKIPSD,NCK interacting protein with SH3 domain,cytosol|intermediate filament|COP9 signalosome|,NLS-bearing protein import into nucleus|cytoskeleton organization|signal transduction|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|,protein binding|cytoskeletal protein binding|SH3 domain binding|,10,-2.4,2.16,10,0,0,-2.4,1.77,0.319,-6.7,2.5
ENSMUSG00000020185,E2F7,E2F transcription factor 7,nucleus|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|placenta development|sprouting angiogenesis|transcription, DNA-templated|negative regulation of cell proliferation|DNA damage response, signal transduction by p53 class mediator|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|positive regulation of transcription from RNA polymerase II promoter|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of G1/S transition of mitotic cell cycle|",core promoter binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|identical protein binding|,10,2.6,3.08,10,0,0,1.4,1.77,0.319,-2.6,6.3
ENSMUSG00000024370,CDC23,cell division cycle 23,intracellular|nucleoplasm|anaphase-promoting complex|cytosol|,mitotic G1 phase|mitotic cell cycle|ubiquitin-dependent protein catabolic process|cell cycle|mitotic nuclear division|mitotic metaphase plate congression|metaphase/anaphase transition of mitotic cell cycle|mitotic spindle assembly checkpoint|regulation of exit from mitosis|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|,7,0,0,9,2.9,2.2,-1.6,1.77,0.319,-5.2,5.2
ENSMUSG00000039168,DAP,death-associated protein,None,"autophagy|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of autophagy|negative regulation of NF-kappaB transcription factor activity|cellular response to amino acid starvation|negative regulation of transcription, DNA-templated|apoptotic signaling pathway|",death domain binding|,10,-1.7,2.66,10,2.7,1,-1.8,1.77,0.319,-6.8,5.1
ENSMUSG00000025742,PRPS2,phosphoribosyl pyrophosphate synthetase 2,ribose phosphate diphosphokinase complex|extracellular vesicular exosome|,5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|AMP biosynthetic process|phosphorylation|organ regeneration|,magnesium ion binding|ribose phosphate diphosphokinase activity|ATP binding|AMP binding|kinase activity|GDP binding|carbohydrate binding|protein homodimerization activity|ADP binding|,10,-1.4,2.16,10,1.5,1.23,1.4,1.77,0.319,-3.1,3.8
ENSMUSG00000020413,HUS1,HUS1 checkpoint homolog (S. pombe),nucleus|nucleoplasm|nucleolus|cytoplasm|checkpoint clamp complex|,DNA damage checkpoint|double-strand break repair via homologous recombination|regulation of protein phosphorylation|DNA replication|DNA repair|protein phosphorylation|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|negative regulation of DNA replication|response to UV|embryo development|cellular response to ionizing radiation|,protein binding|,10,0.2,0.0315,10,1,1.93,1,1.77,0.319,-2.1,6
ENSMUSG00000024386,PROC,protein C (inactivator of coagulation factors Va and VIIIa),extracellular region|extracellular region|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|,proteolysis|proteolysis|blood coagulation|peptidyl-glutamic acid carboxylation|negative regulation of blood coagulation|negative regulation of apoptotic process|post-translational protein modification|cellular protein metabolic process|leukocyte migration|,serine-type endopeptidase activity|calcium ion binding|protein binding|,1,-3.5,1.88,0,0,0,-3.5,1.76,0.321,-7,1.2
ENSMUSG00000096042,GM20782,"predicted gene, 20782",membrane|integral component of membrane|,None,None,1,1.6,0.884,1,2,1.06,1.8,1.76,0.321,-1.4,4
ENSMUSG00000021774,UBE2E1,ubiquitin-conjugating enzyme E2E 1,ubiquitin ligase complex|nucleus|nucleoplasm|cytosol|,protein polyubiquitination|mitotic cell cycle|ubiquitin-dependent protein catabolic process|mitotic spindle assembly checkpoint|histone monoubiquitination|protein ubiquitination|cytokine-mediated signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|ISG15-protein conjugation|histone H2B ubiquitination|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K48-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|ATP binding|ISG15 ligase activity|,10,-1.8,1.82,10,-0.8,0.343,-1.5,1.76,0.321,-7.7,2.9
ENSMUSG00000034412,TBC1D10A,"TBC1 domain family, member 10A",microvillus|extracellular vesicular exosome|,positive regulation of Rab GTPase activity|positive regulation of proteolysis|activation of cysteine-type endopeptidase activity|,guanyl-nucleotide exchange factor activity|Rab GTPase activator activity|protein binding|PDZ domain binding|,0,0,0,1,-2.8,1.88,-2.8,1.76,0.321,-5,1.4
ENSMUSG00000045110,RASSF8,Ras association (RalGDS/AF-6) domain family (N-terminal) member 8,None,signal transduction|,None,1,-3.5,1.88,0,0,0,-3.5,1.76,0.321,-7,1.2
ENSMUSG00000019813,CEP57L1,centrosomal protein 57kDa-like 1,cellular_component|cytoplasm|microtubule organizing center|microtubule|,biological_process|microtubule anchoring|,molecular_function|microtubule binding|identical protein binding|gamma-tubulin binding|,0,0,0,1,-2.8,1.88,-2.8,1.76,0.321,-5,1.4
ENSMUSG00000052135,FOXO6,forkhead box O6,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,1,-5.8,2.56,1,1.5,0.687,-5.7,1.76,0.321,-11,2
ENSMUSG00000076754,TRGV2,T cell receptor gamma variable 2,None,None,None,4,-3.4,0.475,4,-3.4,1.41,-3.4,1.75,0.322,-7,0.7
ENSMUSG00000059743,FDPS,farnesyl diphosphate synthase,nucleus|cytoplasm|mitochondrion|cytosol|,cholesterol biosynthetic process|viral process|geranyl diphosphate biosynthetic process|small molecule metabolic process|farnesyl diphosphate biosynthetic process|,dimethylallyltranstransferase activity|geranyltranstransferase activity|poly(A) RNA binding|metal ion binding|,10,-0.7,0.663,10,-0.9,1.24,-0.8,1.75,0.322,-8.6,1.5
ENSMUSG00000031785,GPR56,G protein-coupled receptor 56,integral component of plasma membrane|integral component of membrane|extracellular vesicular exosome|glial limiting end-foot|,angiogenesis|cell adhesion|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|Rho protein signal transduction|cell-cell signaling|brain development|negative regulation of cell proliferation|vascular endothelial growth factor production|cerebral cortex radial glia guided migration|layer formation in cerebral cortex|positive regulation of Rho protein signal transduction|positive regulation of cell adhesion|protein kinase C signaling|negative regulation of neuron migration|,G-protein coupled receptor activity|collagen binding|extracellular matrix binding|,0,0,0,1,2.6,1.86,2.6,1.75,0.322,-1.4,5
ENSMUSG00000062791,GM382,predicted gene 382,cellular_component|,biological_process|,molecular_function|,1,-3.5,1.87,0,0,0,-3.5,1.75,0.322,-7,1.2
ENSMUSG00000044086,LMOD3,leiomodin 3 (fetal),cytoplasm|cytoskeleton|,None,tropomyosin binding|,0,0,0,1,2.6,1.86,2.6,1.75,0.322,-1.4,5
ENSMUSG00000024087,CYP1B1,"cytochrome P450, family 1, subfamily B, polypeptide 1",mitochondrion|endoplasmic reticulum membrane|,angiogenesis|trabecular meshwork development|cellular aromatic compound metabolic process|xenobiotic metabolic process|xenobiotic metabolic process|nitric oxide biosynthetic process|cell adhesion|visual perception|steroid metabolic process|estrogen metabolic process|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|toxin metabolic process|response to toxic substance|positive regulation vascular endothelial growth factor production|sterol metabolic process|arachidonic acid metabolic process|arachidonic acid metabolic process|epoxygenase P450 pathway|collagen fibril organization|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity|negative regulation of cell adhesion mediated by integrin|retinol metabolic process|retinal metabolic process|positive regulation of apoptotic process|endothelial cell migration|small molecule metabolic process|positive regulation of angiogenesis|positive regulation of JAK-STAT cascade|membrane lipid catabolic process|blood vessel morphogenesis|oxidation-reduction process|retinal blood vessel morphogenesis|cellular response to hydrogen peroxide|cellular response to organic cyclic compound|endothelial cell-cell adhesion|omega-hydroxylase P450 pathway|positive regulation of gene expression involved in extracellular matrix organization|regulation of reactive oxygen species metabolic process|,"monooxygenase activity|monooxygenase activity|iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|heme binding|heme binding|aromatase activity|",10,3.9,1.6,10,-1.6,1.96,-1.3,1.74,0.324,-4.6,6.6
ENSMUSG00000033068,ENTPD6,ectonucleoside triphosphate diphosphohydrolase 6 (putative),Golgi membrane|extracellular space|plasma membrane|cell surface|integral component of membrane|extracellular vesicular exosome|,metabolic process|response to magnesium ion|response to calcium ion|,"guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity|nucleoside-triphosphatase activity|uridine-diphosphatase activity|",10,3.5,1.41,10,-3.2,3.29,-1,1.74,0.324,-9.1,5.7
ENSMUSG00000063810,ALMS1,Alstrom syndrome 1,spindle pole|cytoplasm|centrosome|centriole|cytosol|cilium|,G2/M transition of mitotic cell cycle|mitotic cell cycle|endosomal transport|regulation of stress fiber assembly|,molecular_function|protein binding|,10,-0.6,0.405,10,-2.9,3.39,-2.2,1.74,0.324,-7.4,3.8
ENSMUSG00000033983,COIL,coilin,female germ cell nucleus|nucleus|nucleoplasm|nucleolus|cytoplasm|Cajal body|membrane|,oxidation-reduction process|,protein binding|protein C-terminus binding|disulfide oxidoreductase activity|identical protein binding|,0,0,0,1,2.6,1.85,2.6,1.74,0.324,-1.4,5
ENSMUSG00000029711,EPO,erythropoietin,extracellular region|extracellular space|cell surface|,"apoptotic process|signal transduction|embryo implantation|aging|blood circulation|positive regulation of cell proliferation|response to salt stress|negative regulation of calcium ion transport into cytosol|peptidyl-serine phosphorylation|response to lipopolysaccharide|response to vitamin A|response to testosterone|positive regulation of tyrosine phosphorylation of Stat5 protein|hemoglobin biosynthetic process|erythrocyte maturation|response to estrogen|positive regulation of neuron differentiation|positive regulation of DNA replication|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|positive regulation of Ras protein signal transduction|response to axon injury|response to electrical stimulus|response to hyperoxia|regulation of transcription from RNA polymerase II promoter in response to hypoxia|response to interleukin-1|cellular response to hypoxia|cellular hyperosmotic response|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|negative regulation of erythrocyte apoptotic process|negative regulation of cation channel activity|",erythropoietin receptor binding|hormone activity|protein binding|protein kinase activator activity|,9,-3.4,1.76,8,1.4,1.9,1.3,1.74,0.324,-9.7,5.4
ENSMUSG00000026134,PRIM2,"primase, DNA, polypeptide 2 (58kDa)",nucleoplasm|primosome complex|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA strand elongation involved in DNA replication|telomere maintenance via semi-conservative replication|","DNA binding|DNA primase activity|metal ion binding|4 iron, 4 sulfur cluster binding|",9,-2.3,1.74,8,-1.9,0.155,-2.2,1.74,0.324,-7,2
ENSMUSG00000031400,G6PDX,glucose-6-phosphate dehydrogenase X-linked,nucleus|cytoplasm|cytosol|cytoplasmic side of plasma membrane|membrane|intracellular membrane-bounded organelle|extracellular vesicular exosome|,"cytokine production|cytokine production|angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure|vasodilation by angiotensin involved in regulation of systemic arterial blood pressure|carbohydrate metabolic process|glucose metabolic process|pentose-phosphate shunt|cholesterol biosynthetic process|NADP metabolic process|NADPH regeneration|NADP biosynthetic process|NADP biosynthetic process|glutathione metabolic process|glutathione metabolic process|response to oxidative stress|pentose-phosphate shunt, oxidative branch|negative regulation of protein glutathionylation|pentose biosynthetic process|pentose biosynthetic process|pentose biosynthetic process|interleukin-10 production|interleukin-12 production|cellular response to oxidative stress|regulation of multicellular organism growth|erythrocyte maturation|regulation of neuron apoptotic process|response to ethanol|ribose phosphate biosynthetic process|erythrocyte development|glucose 6-phosphate metabolic process|oxidation-reduction process|oxidation-reduction process|",glucose-6-phosphate dehydrogenase activity|glucose-6-phosphate dehydrogenase activity|glucose-6-phosphate dehydrogenase activity|glucose binding|oxidoreductase activity|carbohydrate binding|protein homodimerization activity|protein homodimerization activity|NADP binding|,10,-3.6,1.08,10,2.8,4.43,2.7,1.73,0.326,-4.9,6.6
ENSMUSG00000058656,SAMD12,sterile alpha motif domain containing 12,None,None,None,2,-2.3,1.85,0,0,0,-2.3,1.73,0.326,-5,1.4
ENSMUSG00000041681,IAPP,islet amyloid polypeptide,extracellular region|extracellular space|neuronal cell body|,apoptotic process|signal transduction|cell-cell signaling|sensory perception of pain|endocrine pancreas development|eating behavior|negative regulation of cell differentiation|negative regulation of bone resorption|,receptor binding|hormone activity|identical protein binding|,0,0,0,1,-2.8,1.84,-2.8,1.73,0.326,-5,1.4
ENSMUSG00000024501,DPYSL3,dihydropyrimidinase-like 3,extracellular space|cytosol|cytosol|lamellipodium|growth cone|filamentous actin|cell body|exocytic vesicle|,pyrimidine nucleobase catabolic process|axon guidance|positive regulation of neuron projection development|negative regulation of neuron projection development|negative regulation of cell migration|response to axon injury|actin filament bundle assembly|protein homooligomerization|positive regulation of filopodium assembly|actin crosslink formation|cellular response to cytokine stimulus|,"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|SH3 domain binding|chondroitin sulfate binding|phosphoprotein binding|",10,-0.7,0.683,10,-1.9,1.71,-2.4,1.73,0.326,-6.1,0.9
ENSMUSG00000020374,RASGEF1C,"RasGEF domain family, member 1C",intracellular|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,guanyl-nucleotide exchange factor activity|,0,0,0,2,2.9,1.84,2.9,1.73,0.326,-4.3,6
ENSMUSG00000034275,IGSF9B,"immunoglobulin superfamily, member 9B",plasma membrane|integral component of membrane|,None,None,0,0,0,1,-2.8,1.84,-2.8,1.73,0.326,-5,1.4
ENSMUSG00000078921,TGTP2,T cell specific GTPase 2,cellular_component|,biological_process|,molecular_function|,2,-0.2,0.0225,2,-4.6,2.73,-4.6,1.73,0.326,-9,2.7
ENSMUSG00000027326,CASC5,cancer susceptibility candidate 5,condensed chromosome kinetochore|acrosomal vesicle|nucleus|nucleoplasm|cytoplasm|cytosol|extracellular vesicular exosome|,mitotic cell cycle|acrosome assembly|nucleosome assembly|mitotic nuclear division|attachment of spindle microtubules to kinetochore|negative regulation of phosphatase activity|centromere-specific nucleosome assembly|protein localization to kinetochore|spindle assembly checkpoint|,protein binding|,9,-1.6,0.76,10,1.4,2.08,1.2,1.73,0.326,-6.5,4.7
ENSMUSG00000003444,MED29,mediator complex subunit 29,nucleus|mediator complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",protein binding|,0,0,0,1,-2.8,1.84,-2.8,1.73,0.326,-5,1.4
ENSMUSG00000046519,GOLPH3L,golgi phosphoprotein 3-like,Golgi membrane|Golgi cisterna membrane|trans-Golgi network membrane|,Golgi organization|positive regulation of protein secretion|,protein binding|phosphatidylinositol-4-phosphate binding|,1,-3.4,1.84,0,0,0,-3.4,1.73,0.326,-7,1.2
ENSMUSG00000021693,KIF2A,kinesin heavy chain member 2A,spindle pole|centrosome|cytosol|kinesin complex|spindle microtubule|membrane|,mitotic cell cycle|microtubule-based movement|mitotic spindle organization|mitotic nuclear division|nervous system development|blood coagulation|metabolic process|metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell differentiation|,motor activity|microtubule motor activity|protein binding|ATP binding|microtubule binding|,10,-3.3,1.95,10,-0.9,0.679,-1,1.72,0.327,-9.3,2
ENSMUSG00000031271,SERPINA7,"serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7",extracellular region|extracellular region|extracellular space|extracellular vesicular exosome|,aging|post-embryonic development|negative regulation of endopeptidase activity|regulation of proteolysis|response to vitamin A|response to prostaglandin E|response to drug|response to peptide hormone|response to corticosterone|thyroid hormone transport|,serine-type endopeptidase inhibitor activity|hormone binding|,10,4.6,1.13,9,2.5,1.65,3.1,1.72,0.327,-2.7,10.5
ENSMUSG00000025337,SBDS,Shwachman-Bodian-Diamond syndrome,spindle pole|nucleus|nucleoplasm|nucleolus|cytoplasm|,inner cell mass cell proliferation|rRNA processing|cell proliferation|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|ribosomal large subunit biogenesis|mitotic spindle stabilization|bone marrow development|,protein binding|microtubule binding|rRNA binding|ribosome binding|poly(A) RNA binding|,10,-2.8,2.6,10,0,0,-2.7,1.72,0.327,-5.8,1
ENSMUSG00000044006,CILP2,cartilage intermediate layer protein 2,proteinaceous extracellular matrix|extracellular vesicular exosome|,None,None,9,0,0,10,-2.5,3.08,-2.5,1.72,0.327,-8.8,1.6
ENSMUSG00000039361,PICALM,phosphatidylinositol binding clathrin assembly protein,nucleus|Golgi apparatus|coated pit|coated pit|membrane|AP-2 adaptor complex|clathrin coat of coated pit|vesicle|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|postsynaptic membrane|perinuclear region of cytoplasm|neurofibrillary tangle|,"protein complex assembly|receptor-mediated endocytosis|receptor-mediated endocytosis|axonogenesis|cell proliferation|negative regulation of gene expression|synaptic vesicle maturation|vesicle-mediated transport|endosomal transport|hemopoiesis|regulation of endocytosis|receptor internalization|regulation of protein localization|cargo loading into vesicle|positive regulation of transcription, DNA-templated|negative regulation of receptor-mediated endocytosis|clathrin coat assembly|dendrite morphogenesis|iron ion homeostasis|clathrin-mediated endocytosis|iron ion import into cell|positive regulation of neuron death|positive regulation of beta-amyloid formation|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|",protein binding|1-phosphatidylinositol binding|clathrin binding|clathrin binding|clathrin binding|clathrin heavy chain binding|clathrin adaptor activity|,10,2.5,1.56,10,1.5,0.672,2.1,1.72,0.327,-8.6,7.3
ENSMUSG00000021281,TNFAIP2,"tumor necrosis factor, alpha-induced protein 2",exocyst|extracellular space|,angiogenesis|exocytosis|cell differentiation|,None,10,-1.3,1.7,10,-0.5,0.606,-0.8,1.71,0.329,-13.2,3.4
ENSMUSG00000026014,RAPH1,Ras association (RalGDS/AF-6) and pleckstrin homology domains 1,cytoplasm|cytoskeleton|plasma membrane|lamellipodium|filopodium|,cell-matrix adhesion|signal transduction|axon extension|,None,0,0,0,1,2.6,1.82,2.6,1.71,0.329,-1.4,5
ENSMUSG00000059834,SCLT1,sodium channel and clathrin linker 1,cytoplasm|centrosome|centriole|microtubule cytoskeleton|extracellular vesicular exosome|clathrin complex|ciliary transition fiber|,cilium assembly|clustering of voltage-gated sodium channels|,protein C-terminus binding|sodium channel regulator activity|clathrin binding|,0,0,0,1,2.6,1.82,2.6,1.71,0.329,-1.4,5
ENSMUSG00000038225,CCDC111,N/A,None,None,None,0,0,0,1,2.6,1.82,2.6,1.71,0.329,-1.4,5
ENSMUSG00000094130,RPP14,ribonuclease P/MRP 14kDa subunit,nucleus|,"tRNA processing|RNA phosphodiester bond hydrolysis, endonucleolytic|",RNA binding|ribonuclease P activity|,0,0,0,1,2.6,1.82,2.6,1.71,0.329,-1.4,5
ENSMUSG00000040167,IKZF5,IKAROS family zinc finger 5 (Pegasus),nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|metal ion binding|,1,-1.9,0.707,1,-2.5,1.21,-2.4,1.71,0.329,-5,1.3
ENSMUSG00000061533,CEP128,centrosomal protein 128kDa,spindle pole|cytoplasm|centriole|microtubule organizing center|,None,None,10,-1.1,0.839,10,-1.2,1.02,-1.2,1.71,0.329,-4.2,1.4
ENSMUSG00000063179,PSTK,phosphoseryl-tRNA kinase,mitochondrion|,selenocysteine incorporation|phosphorylation|selenocysteinyl-tRNA(Sec) biosynthetic process|,tRNA binding|ATP binding|kinase activity|,10,-0.6,0.898,9,4.8,1.59,-0.8,1.7,0.33,-9.3,9
ENSMUSG00000022589,CYP11B2,"cytochrome P450, family 11, subfamily B, polypeptide 2",mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane|,regulation of blood volume by renal aldosterone|renal water homeostasis|C21-steroid hormone biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process|steroid metabolic process|sterol metabolic process|aldosterone biosynthetic process|aldosterone biosynthetic process|cellular response to hormone stimulus|cortisol biosynthetic process|cellular response to potassium ion|small molecule metabolic process|potassium ion homeostasis|sodium ion homeostasis|oxidation-reduction process|,steroid 11-beta-monooxygenase activity|iron ion binding|heme binding|heme binding|corticosterone 18-monooxygenase activity|,10,1.5,0.634,10,-2.4,1.4,-2.6,1.7,0.33,-8,3.7
ENSMUSG00000023949,TCTE1,t-complex-associated-testis-expressed 1,None,None,None,10,-6.3,3.48,9,1.7,1.31,-1.3,1.7,0.33,-11.8,4.4
ENSMUSG00000054958,NT5C1A,"5'-nucleotidase, cytosolic IA",cytosol|cytosol|,purine nucleobase metabolic process|purine nucleotide catabolic process|pyrimidine nucleobase metabolic process|nucleoside metabolic process|purine nucleoside monophosphate catabolic process|dephosphorylation|dephosphorylation|dephosphorylation|small molecule metabolic process|adenosine metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|,nucleotide binding|magnesium ion binding|5'-nucleotidase activity|5'-nucleotidase activity|,10,-2,2.26,10,0.7,0.715,-1.8,1.7,0.33,-8.3,4.4
ENSMUSG00000035325,SEC31A,SEC31 homolog A (S. cerevisiae),Golgi membrane|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ER to Golgi transport vesicle membrane|vesicle coat|COPII vesicle coat|ER to Golgi transport vesicle|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,antigen processing and presentation of peptide antigen via MHC class I|ER to Golgi vesicle-mediated transport|ER to Golgi vesicle-mediated transport|activation of signaling protein activity involved in unfolded protein response|protein transport|protein N-linked glycosylation via asparagine|antigen processing and presentation of exogenous peptide antigen via MHC class II|endoplasmic reticulum unfolded protein response|post-translational protein modification|cellular protein metabolic process|COPII vesicle coating|response to calcium ion|membrane organization|,protein binding|calcium-dependent protein binding|,1,-3.4,1.81,0,0,0,-3.4,1.7,0.33,-7,1.2
ENSMUSG00000063895,NUPL1,nucleoporin like 1,nuclear envelope|nuclear pore|nuclear membrane|,mitotic cell cycle|carbohydrate metabolic process|nucleocytoplasmic transport|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|mRNA transport|transmembrane transport|,nucleocytoplasmic transporter activity|protein binding|,10,1,1.48,10,1.4,0.42,1,1.7,0.33,-4.2,3.9
ENSMUSG00000030782,TGFB1I1,transforming growth factor beta 1 induced transcript 1,intracellular|cytoplasm|cytoskeleton|focal adhesion|nuclear matrix|extracellular matrix|,"transcription from RNA polymerase II promoter|cell adhesion|negative regulation of cell proliferation|response to heat|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|morphogenesis of embryonic epithelium|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|androgen receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process|epithelial cell differentiation|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|",transcription coactivator activity|transcription coactivator activity|protein binding|zinc ion binding|Roundabout binding|androgen receptor binding|androgen receptor binding|I-SMAD binding|,9,-1.9,3.26,10,-0.2,0.0224,-1.4,1.7,0.33,-5.7,1.5
ENSMUSG00000031241,TBX22,T-box 22,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|negative regulation of transcription, DNA-templated|",DNA binding|sequence-specific DNA binding transcription factor activity|,10,-6.2,3.13,10,-1,0.911,-0.9,1.69,0.332,-10.4,11.3
ENSMUSG00000036459,WTIP,Wilms tumor 1 interacting protein,cytoplasmic mRNA processing body|nucleus|adherens junction|,"response to hypoxia|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell morphogenesis|gene silencing by miRNA|negative regulation of hippo signaling|positive regulation of gene silencing by miRNA|",transcription corepressor activity|protein binding|zinc ion binding|,0,0,0,1,-2.8,1.8,-2.8,1.69,0.332,-5,1.4
ENSMUSG00000052707,TNRC6A,trinucleotide repeat containing 6A,cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|,epidermal growth factor receptor signaling pathway|Notch signaling pathway|fibroblast growth factor receptor signaling pathway|cellular response to starvation|gene expression|negative regulation of translation involved in gene silencing by miRNA|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|,nucleotide binding|protein binding|poly(A) RNA binding|,1,-3.5,1.88,1,-1.4,0.253,-3.3,1.69,0.332,-7,1.1
ENSMUSG00000030549,RHCG,"Rh family, C glycoprotein",plasma membrane|plasma membrane|integral component of plasma membrane|basolateral plasma membrane|apical plasma membrane|cytoplasmic vesicle|extracellular vesicular exosome|,cellular ion homeostasis|regulation of pH|ammonium transport|ammonium transport|amine transport|epithelial cell differentiation|homeostatic process|transmembrane transport|transepithelial ammonium transport|ammonium transmembrane transport|ammonium transmembrane transport|ammonium transmembrane transport|,ammonium transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding|,0,0,0,1,-2.8,1.8,-2.8,1.69,0.332,-5,1.4
ENSMUSG00000006998,PSMD2,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 2",proteasome complex|nucleoplasm|cytosol|proteasome regulatory particle|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|regulation of protein catabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",protein binding|enzyme regulator activity|,8,1.3,1.21,8,0.9,0.675,1.2,1.68,0.334,-5,5.7
ENSMUSG00000026821,RALGDS,ral guanine nucleotide dissociation stimulator,cytosol|,Ras protein signal transduction|positive regulation of GTPase activity|neurotrophin TRK receptor signaling pathway|regulation of catalytic activity|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|,small GTPase regulator activity|small GTPase regulator activity|guanyl-nucleotide exchange factor activity|protein binding|,10,-1.6,1.75,10,-1.1,0.204,-1.4,1.68,0.334,-6.1,2.6
ENSMUSG00000023027,ATF1,activating transcription factor 1,nucleus|nucleoplasm|transcription factor complex|,toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription from RNA polymerase II promoter|positive regulation of neuron projection development|response to organic cyclic compound|response to cobalt ion|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|cellular protein complex assembly|innate immune response|positive regulation of DNA replication|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|stress-activated MAPK cascade|,RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|protein complex binding|protein heterodimerization activity|,10,-3.3,1.16,10,5.8,2.54,-1.8,1.68,0.334,-6.7,9.9
ENSMUSG00000030541,IDH2,"isocitrate dehydrogenase 2 (NADP+), mitochondrial",mitochondrion|mitochondrial inner membrane|mitochondrial matrix|,carbohydrate metabolic process|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|cellular metabolic process|small molecule metabolic process|,magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|isocitrate dehydrogenase (NADP+) activity|NAD binding|,9,-2.8,0.558,10,-1.4,1.64,-1.9,1.68,0.334,-6.8,4.2
ENSMUSG00000031910,HAS3,hyaluronan synthase 3,plasma membrane|integral component of plasma membrane|integral component of membrane|hyaluranon cable|,"carbohydrate metabolic process|glycosaminoglycan metabolic process|hyaluronan metabolic process|hyaluronan biosynthetic process|hyaluronan biosynthetic process|hyaluronan biosynthetic process|small molecule metabolic process|extracellular polysaccharide biosynthetic process|positive regulation of transcription, DNA-templated|extracellular matrix assembly|positive regulation of hyaluranon cable assembly|",hyaluronan synthase activity|,10,-1.7,0.99,9,-1.5,0.849,-1.6,1.68,0.334,-6.4,2.2
ENSMUSG00000027765,P2RY1,"purinergic receptor P2Y, G-protein coupled, 1",plasma membrane|plasma membrane|integral component of plasma membrane|basolateral plasma membrane|apical plasma membrane|dendrite|cell body|postsynaptic membrane|neuronal postsynaptic density|,positive regulation of protein phosphorylation|adenosine receptor signaling pathway|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|brain development|aging|blood coagulation|response to mechanical stimulus|regulation of receptor activity|negative regulation of norepinephrine secretion|sensory perception of pain|signal transduction involved in regulation of gene expression|platelet activation|positive regulation of inositol trisphosphate biosynthetic process|G-protein coupled purinergic nucleotide receptor signaling pathway|regulation of vasodilation|eating behavior|positive regulation of ion transport|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hormone secretion|negative regulation of binding|positive regulation of penile erection|positive regulation of ERK1 and ERK2 cascade|response to growth factor|protein localization to plasma membrane|relaxation of muscle|,receptor activity|protein binding|ATP binding|A1 adenosine receptor binding|ADP binding|G-protein coupled purinergic nucleotide receptor activity|ATP-activated nucleotide receptor activity|ADP-activated nucleotide receptor activity|protein heterodimerization activity|scaffold protein binding|,10,-5,1.46,10,1.6,1.61,1.4,1.68,0.334,-7.8,5
ENSMUSG00000059498,FCGR3,"Fc receptor, IgG, low affinity III",cell|plasma membrane|membrane|integral component of membrane|extracellular vesicular exosome|,"antibody-dependent cellular cytotoxicity|positive regulation of type IIa hypersensitivity|positive regulation of type III hypersensitivity|positive regulation of type I hypersensitivity|positive regulation of type I hypersensitivity|serotonin secretion|phagocytosis, recognition|phagocytosis, engulfment|cell surface receptor signaling pathway|neutrophil chemotaxis|Fc-gamma receptor signaling pathway|positive regulation of tumor necrosis factor biosynthetic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|mast cell activation|mast cell activation|positive regulation of phagocytosis|regulation of immune response|",IgG receptor activity|IgG receptor activity|IgG binding|,9,-2.5,3.87,9,5.9,1.96,-2.3,1.67,0.335,-6.6,10.9
ENSMUSG00000033952,ASPM,"asp (abnormal spindle) homolog, microcephaly associated (Drosophila)",spindle pole|nucleus|cytoplasm|midbody|,neuron migration|positive regulation of neuroblast proliferation|mitotic nuclear division|spermatogenesis|forebrain neuroblast division|negative regulation of neuron differentiation|negative regulation of asymmetric cell division|oogenesis|developmental growth|maintenance of centrosome location|positive regulation of canonical Wnt signaling pathway|,calmodulin binding|,10,-5,4.55,10,0,0,-4.9,1.67,0.335,-10.1,1.3
ENSMUSG00000040152,THBS1,thrombospondin 1,extracellular region|fibrinogen complex|extracellular space|endoplasmic reticulum|external side of plasma membrane|cell surface|sarcoplasmic reticulum|secretory granule|extracellular matrix|extracellular matrix|extracellular matrix|platelet alpha granule|platelet alpha granule lumen|extracellular vesicular exosome|,activation of MAPK activity|response to hypoxia|negative regulation of endothelial cell proliferation|negative regulation of endothelial cell proliferation|negative regulation of cell-matrix adhesion|sprouting angiogenesis|chronic inflammatory response|platelet degranulation|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of dendritic cell antigen processing and presentation|outflow tract morphogenesis|endocardial cushion development|growth plate cartilage development|immune response|response to unfolded protein|cell cycle arrest|cell adhesion|blood coagulation|response to mechanical stimulus|response to glucose|positive regulation of endothelial cell migration|negative regulation of endothelial cell migration|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of nitric oxide mediated signal transduction|negative regulation of cGMP-mediated signaling|negative regulation of plasminogen activation|positive regulation of macrophage chemotaxis|positive regulation of fibroblast migration|positive regulation of cell-substrate adhesion|cell migration|negative regulation of angiogenesis|peptide cross-linking|platelet activation|positive regulation of blood coagulation|extracellular matrix organization|positive regulation of cell migration|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|response to magnesium ion|response to progesterone|negative regulation of interleukin-12 production|positive regulation of transforming growth factor beta1 production|response to testosterone|cellular response to heat|response to endoplasmic reticulum stress|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of phosphorylation|response to drug|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of macrophage activation|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|engulfment of apoptotic cell|positive regulation of translation|positive regulation of angiogenesis|behavioral response to pain|positive regulation of chemotaxis|response to calcium ion|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of fibrinolysis|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process|negative regulation of extrinsic apoptotic signaling pathway|,phosphatidylserine binding|glycoprotein binding|fibronectin binding|integrin binding|calcium ion binding|protein binding|heparin binding|fibroblast growth factor binding|low-density lipoprotein particle binding|identical protein binding|laminin binding|proteoglycan binding|transforming growth factor beta binding|transforming growth factor beta binding|fibrinogen binding|collagen V binding|,9,-0.8,0.187,10,-1.5,1.84,-1.2,1.67,0.335,-7.9,4.6
ENSMUSG00000023439,GNB3,"guanine nucleotide binding protein (G protein), beta polypeptide 3",plasma membrane|neuron projection|cell body|,energy reserve metabolic process|GTP catabolic process|G-protein coupled receptor signaling pathway|synaptic transmission|regulation of blood pressure|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|protein binding|GTPase binding|,0,0,0,1,2.5,1.78,2.5,1.67,0.335,-1.4,5
ENSMUSG00000010047,HYAL2,hyaluronoglucosaminidase 2,Golgi membrane|cytoplasm|lysosome|endoplasmic reticulum|cytosol|plasma membrane|microvillus|cell surface|cell surface|cytoplasmic membrane-bounded vesicle|apical plasma membrane|endocytic vesicle|anchored component of external side of plasma membrane|anchored component of external side of plasma membrane|cytoplasmic vesicle|membrane raft|anchored component of plasma membrane|perinuclear region of cytoplasm|,response to reactive oxygen species|kidney development|hematopoietic progenitor cell differentiation|carbohydrate metabolic process|glycosaminoglycan catabolic process|response to virus|multicellular organismal aging|negative regulation of fibroblast migration|fusion of virus membrane with host plasma membrane|transformation of host cell by virus|transformation of host cell by virus|glycosaminoglycan metabolic process|hyaluronan metabolic process|hyaluronan catabolic process|hyaluronan catabolic process|negative regulation of cell growth|positive regulation of urine volume|monocyte activation|positive regulation of protein import into nucleus|negative regulation of MAP kinase activity|small molecule metabolic process|cellular response to fibroblast growth factor stimulus|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|viral entry into host cell|skeletal system morphogenesis|positive regulation of inflammatory response|cartilage development|defense response to virus|negative regulation of protein kinase B signaling|multicellular organismal iron ion homeostasis|negative regulation of protein tyrosine kinase activity|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|cellular response to transforming growth factor beta stimulus|positive regulation of interleukin-8 secretion|positive regulation of interleukin-6 secretion|positive regulation of extrinsic apoptotic signaling pathway|,virus receptor activity|hyalurononglucosaminidase activity|hyalurononglucosaminidase activity|protein binding|hyaluronic acid binding|enzyme binding|receptor signaling protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|hyaluronoglucuronidase activity|transforming growth factor beta binding|,0,0,0,1,2.5,1.78,2.5,1.67,0.335,-1.4,5
ENSMUSG00000059481,PLG,plasminogen,extracellular region|extracellular space|plasma membrane|cell surface|platelet alpha granule lumen|extrinsic component of external side of plasma membrane|extracellular vesicular exosome|blood microparticle|,platelet degranulation|blood coagulation|blood coagulation|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|extracellular matrix disassembly|extracellular matrix disassembly|platelet activation|extracellular matrix organization|tissue regeneration|fibrinolysis|cellular protein metabolic process|myoblast differentiation|muscle cell cellular homeostasis|tissue remodeling|proteolysis involved in cellular protein catabolic process|negative regulation of fibrinolysis|positive regulation of fibrinolysis|trophoblast giant cell differentiation|labyrinthine layer blood vessel development|mononuclear cell migration|negative regulation of cell-cell adhesion mediated by cadherin|,serine-type endopeptidase activity|protein binding|serine-type peptidase activity|protein domain specific binding|apolipoprotein binding|,10,0.6,0.535,10,1.7,1.54,1,1.67,0.335,-2.3,5.9
ENSMUSG00000078630,TOMT,transmembrane O-methyltransferase,cellular_component|cytoplasm|,catecholamine metabolic process|sensory perception of sound|methylation|neurotransmitter catabolic process|catecholamine catabolic process|auditory receptor cell development|,methyltransferase activity|O-methyltransferase activity|catechol O-methyltransferase activity|transferase activity|,1,-3.4,1.78,0,0,0,-3.4,1.67,0.335,-7,1.2
ENSMUSG00000039000,UBE3C,ubiquitin protein ligase E3C,proteasome complex|intracellular|nucleus|cytoplasm|,protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|,ubiquitin-protein transferase activity|protein binding|ligase activity|,10,1.2,1.39,10,1,0.45,1.1,1.67,0.335,-3.8,5.6
ENSMUSG00000004612,NKG7,natural killer cell granule protein 7,integral component of plasma membrane|,None,None,0,0,0,1,2.5,1.78,2.5,1.67,0.335,-1.4,5
ENSMUSG00000056429,TGOLN1,trans-golgi network protein,Golgi apparatus|trans-Golgi network|trans-Golgi network|plasma membrane|membrane|integral component of membrane|,None,None,10,-1,2.03,10,-0.3,0.166,-0.9,1.66,0.337,-3.4,1
ENSMUSG00000060780,LRRTM1,leucine rich repeat transmembrane neuronal 1,endoplasmic reticulum|integral component of membrane|cell junction|axon|growth cone|postsynaptic membrane|excitatory synapse|,locomotory behavior|biological_process|protein localization to synapse|exploration behavior|synapse organization|,molecular_function|,1,2.2,1.77,0,0,0,2.2,1.66,0.337,-1.4,5
ENSMUSG00000056763,CSPP1,centrosome and spindle pole associated protein 1,spindle pole|cytoplasm|centrosome|spindle|microtubule|,positive regulation of cytokinesis|positive regulation of cell division|,None,10,1.3,0.537,10,-3.2,1.84,-0.7,1.66,0.337,-8.7,4.4
ENSMUSG00000000782,TCF7,"transcription factor 7 (T-cell specific, HMG-box)",nucleus|transcription factor complex|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|brain development|neural tube development|embryonic genitalia morphogenesis|T cell receptor V(D)J recombination|regulation of cell proliferation|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|alpha-beta T cell differentiation|embryonic digestive tract morphogenesis|embryonic hindgut morphogenesis|generation of neurons|canonical Wnt signaling pathway|cellular response to interleukin-4|",chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|beta-catenin binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,-0.9,0.605,10,-1.6,1.45,-1.3,1.66,0.337,-6.6,3.4
ENSMUSG00000002265,PEG3,paternally expressed 3,nucleus|cytoplasm|,in utero embryonic development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|apoptotic process|multicellular organism growth|genetic imprinting|,sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding|metal ion binding|,10,0.4,0.136,10,-1.3,2.59,-1.2,1.66,0.337,-4.5,2.2
ENSMUSG00000031732,PHLPP2,PH domain and leucine rich repeat protein phosphatase 2,photoreceptor inner segment|nucleus|cytoplasm|cytosol|photoreceptor outer segment membrane|,protein dephosphorylation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|,protein serine/threonine phosphatase activity|metal ion binding|,10,-3.2,0.905,10,2.6,2.46,-2.7,1.66,0.337,-7.7,5.6
ENSMUSG00000036461,ELF1,E74-like factor 1 (ets domain transcription factor),nucleus|nucleus|,"regulation of cytokine production|transcription from RNA polymerase II promoter|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of T cell receptor signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|protein binding|,10,-5,0.131,10,-3.5,1.73,-3.6,1.65,0.339,-9.9,2.1
ENSMUSG00000036977,ANAPC10,anaphase promoting complex subunit 10,nucleoplasm|anaphase-promoting complex|anaphase-promoting complex|cytosol|,G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle|ubiquitin-dependent protein catabolic process|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|,10,-4.9,4.08,8,-0.2,0.0625,-2.8,1.65,0.339,-10.1,4.6
ENSMUSG00000053838,NUDCD3,NudC domain containing 3,None,None,None,10,-2.6,2,10,-0.9,1.03,-2.2,1.65,0.339,-7.5,1.3
ENSMUSG00000030732,CHRDL2,chordin-like 2,extracellular space|cytoplasm|,ossification|cell differentiation|cartilage development|,None,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000071649,B3GAT3,"beta-1,3-glucuronyltransferase 3",Golgi membrane|Golgi apparatus|cis-Golgi network|membrane|integral component of membrane|extracellular vesicular exosome|,carbohydrate metabolic process|glycosaminoglycan biosynthetic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|small molecule metabolic process|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|,galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|glucuronosyltransferase activity|metal ion binding|,10,2.1,1.71,10,-2.1,2.06,2,1.64,0.34,-5.3,5.8
ENSMUSG00000079598,CLEC2L,"C-type lectin domain family 2, member L",integral component of membrane|,None,carbohydrate binding|,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000018634,CRHR1,corticotropin releasing hormone receptor 1,multivesicular body|trans-Golgi network|plasma membrane|integral component of plasma membrane|integral component of membrane|dendrite|intrinsic component of plasma membrane|vesicle|neuronal cell body|apical part of cell|,"response to hypoxia|immune response|activation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|female pregnancy|parturition|memory|visual learning|hormone-mediated signaling pathway|regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|hypothalamus development|adrenal gland development|epithelial cell differentiation|negative regulation of epinephrine secretion|locomotory exploration behavior|response to immobilization stress|fear response|positive regulation of mast cell degranulation|behavioral response to cocaine|behavioral response to ethanol|behavioral response to pain|corticotropin secretion|general adaptation syndrome, behavioral process|long-term synaptic potentiation|cellular response to corticotropin-releasing hormone stimulus|negative regulation of neuron death|negative regulation of voltage-gated calcium channel activity|negative regulation of feeding behavior|regulation of corticosterone secretion|",G-protein alpha-subunit binding|protein binding|corticotrophin-releasing factor receptor activity|protein complex binding|corticotropin-releasing hormone receptor activity|corticotropin-releasing hormone binding|,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000036510,CDH8,"cadherin 8, type 2",plasma membrane|integral component of membrane|synaptic cleft|axon terminus|,"cell adhesion|homophilic cell adhesion|response to cold|cell junction assembly|adherens junction organization|synaptic transmission, glutamatergic|cell-cell junction organization|",calcium ion binding|,1,-3.5,1.9,1,-1.2,0.202,-3.4,1.64,0.34,-7,1.1
ENSMUSG00000032370,LACTB,"lactamase, beta",cytoplasm|mitochondrion|,metabolic process|,hydrolase activity|,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000037149,DDX1,DEAD (Asp-Glu-Ala-Asp) box helicase 1,nucleus|cytoplasm|cytoplasmic stress granule|membrane|ribonucleoprotein complex|cleavage body|tRNA-splicing ligase complex|,"spliceosomal complex assembly|ATP catabolic process|double-strand break repair|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translational initiation|multicellular organismal development|response to virus|DNA duplex unwinding|response to exogenous dsRNA|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|",DNA binding|chromatin binding|transcription cofactor activity|RNA helicase activity|double-stranded RNA binding|nuclease activity|exonuclease activity|protein binding|ATP binding|ATP-dependent helicase activity|poly(A) binding|DNA/RNA helicase activity|poly(A) RNA binding|,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000032633,FLCN,folliculin,nucleus|cytoplasm|plasma membrane|midbody|cell-cell contact zone|,negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|regulation of protein phosphorylation|positive regulation of protein phosphorylation|cell-cell junction assembly|positive regulation of gene expression|negative regulation of gene expression|negative regulation of mitochondrion organization|hemopoiesis|negative regulation of cell growth|negative regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|TOR signaling|regulation of TOR signaling|negative regulation of TOR signaling|positive regulation of TOR signaling|regulation of cytokinesis|negative regulation of Rho protein signal transduction|regulation of histone acetylation|positive regulation of apoptotic process|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|negative regulation of protein localization to nucleus|negative regulation of cell proliferation involved in kidney development|negative regulation of energy homeostasis|regulation of pro-B cell differentiation|negative regulation of ATP biosynthetic process|,protein binding|protein complex binding|,9,-2.7,2.85,9,-0.8,0.481,-1,1.64,0.34,-7.7,1.1
ENSMUSG00000039509,NUP133,nucleoporin 133kDa,condensed chromosome kinetochore|condensed chromosome outer kinetochore|nuclear envelope|nuclear pore|cytosol|membrane|nuclear pore outer ring|nuclear pore outer ring|,mitotic cell cycle|carbohydrate metabolic process|mRNA export from nucleus|nuclear pore organization|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|paraxial mesoderm development|transmembrane transport|,nucleocytoplasmic transporter activity|protein binding|,10,-0.6,0.637,10,-1.1,1.35,-0.9,1.64,0.34,-9.9,4.1
ENSMUSG00000000296,TPD52L1,tumor protein D52-like 1,cytoplasm|perinuclear region of cytoplasm|,G2/M transition of mitotic cell cycle|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAP kinase activity|positive regulation of JNK cascade|positive regulation of apoptotic signaling pathway|,protein binding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|,10,-4.2,0.578,10,-1.2,1.48,-1.2,1.64,0.34,-7.8,2.7
ENSMUSG00000020437,MYO1G,myosin IG,plasma membrane|membrane|myosin complex|extracellular vesicular exosome|,metabolic process|,motor activity|actin binding|calmodulin binding|ATP binding|,0,0,0,1,2.5,1.75,2.5,1.64,0.34,-1.4,5
ENSMUSG00000029281,SMR2,submaxillary gland androgen regulated protein 2,extracellular region|,response to toxic substance|,None,1,-3.3,1.74,0,0,0,-3.3,1.63,0.342,-7,1.2
ENSMUSG00000030134,RASGEF1A,"RasGEF domain family, member 1A",intracellular|,small GTPase mediated signal transduction|cell migration|positive regulation of Ras GTPase activity|positive regulation of Ras protein signal transduction|,Ras guanyl-nucleotide exchange factor activity|,1,2.4,2.16,1,-1.8,0.507,2.3,1.63,0.342,-2.3,6
ENSMUSG00000003436,DLL3,delta-like 3 (Drosophila),integral component of membrane|,skeletal system development|somitogenesis|Notch signaling pathway|compartment pattern specification|paraxial mesoderm development|negative regulation of neurogenesis|,Notch binding|,10,-2.7,2.07,10,2.6,2.47,-1.2,1.63,0.342,-6.2,6.1
ENSMUSG00000022105,RB1,retinoblastoma 1,chromatin|nucleus|nucleoplasm|spindle|SWI/SNF complex|PML body|Rb-E2F complex|,"cell cycle checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|chromatin remodeling|transcription, DNA-templated|negative regulation of protein kinase activity|cell cycle arrest|negative regulation of transcription from RNA polymerase II promoter during mitosis|mitotic cell cycle checkpoint|Ras protein signal transduction|regulation of mitotic cell cycle|viral process|androgen receptor signaling pathway|sister chromatid biorientation|neuron projection development|maintenance of mitotic sister chromatid cohesion|glial cell apoptotic process|skeletal muscle cell differentiation|neuron maturation|enucleate erythrocyte differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of lipid kinase activity|myoblast differentiation|positive regulation of macrophage differentiation|positive regulation of mitotic metaphase/anaphase transition|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|digestive tract development|cell morphogenesis involved in neuron differentiation|negative regulation of epithelial cell proliferation|striated muscle cell differentiation|neuron apoptotic process|protein localization to chromosome, centromeric region|regulation of cohesin localization to chromatin|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of centromere complex assembly|hepatocyte apoptotic process|negative regulation of G1/S transition of mitotic cell cycle|",core promoter binding|RNA polymerase II activating transcription factor binding|DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|kinase binding|ubiquitin protein ligase binding|identical protein binding|androgen receptor binding|phosphoprotein binding|,10,-0.1,0.00626,10,-1.7,1.95,-1.9,1.63,0.342,-7.3,3.3
ENSMUSG00000064254,ETHE1,ethylmalonic encephalopathy 1,nucleus|cytoplasm|mitochondrion|mitochondrial matrix|,"sulfur amino acid metabolic process|sulfur amino acid catabolic process|glutathione metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|sulfide oxidation, using sulfide:quinone oxidoreductase|hydrogen sulfide metabolic process|",iron ion binding|hydrolase activity|sulfur dioxygenase activity|sulfur dioxygenase activity|,1,2.2,1.73,0,0,0,2.2,1.62,0.344,-1.4,5
ENSMUSG00000012520,PHOX2B,paired-like homeobox 2b,nuclear chromatin|,"neuron migration|regulation of respiratory gaseous exchange by neurological system process|noradrenergic neuron differentiation|noradrenergic neuron differentiation|noradrenergic neuron development|brainstem development|transcription, DNA-templated|negative regulation of cell proliferation|glial cell differentiation|regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|cell differentiation in hindbrain|medullary reticular formation development|hindbrain tangential cell migration|skeletal muscle cell differentiation|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|autonomic nervous system development|enteric nervous system development|sympathetic nervous system development|parasympathetic nervous system development|inner ear development|efferent axon development in a lateral line nerve|respiratory system development|retrotrapezoid nucleus neuron differentiation|sympathetic ganglion development|negative regulation of cell cycle arrest|dopaminergic neuron differentiation|dopaminergic neuron differentiation|cellular response to BMP stimulus|neural crest cell migration involved in autonomic nervous system development|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|,10,1.2,0.266,10,-1.4,2.6,-1.2,1.62,0.344,-4.6,4
ENSMUSG00000066755,TNFSF18,"tumor necrosis factor (ligand) superfamily, member 18",extracellular space|plasma membrane|cell surface|integral component of membrane|,T cell proliferation involved in immune response|signal transduction|cell-cell signaling|tumor necrosis factor-mediated signaling pathway|regulation of T cell proliferation|negative regulation of apoptotic process|positive regulation of NF-kappaB transcription factor activity|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|tumor necrosis factor receptor superfamily binding|,10,2,2.65,10,-1.4,1.41,2.1,1.62,0.344,-3.1,7.5
ENSMUSG00000021715,CWC27,CWC27 spliceosome-associated protein homolog (S. cerevisiae),catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|protein folding|",peptidyl-prolyl cis-trans isomerase activity|,1,2.2,1.73,0,0,0,2.2,1.62,0.344,-1.4,5
ENSMUSG00000033122,HSD17B3,hydroxysteroid (17-beta) dehydrogenase 3,endoplasmic reticulum membrane|intracellular membrane-bounded organelle|,androgen biosynthetic process|steroid metabolic process|male genitalia development|small molecule metabolic process|oxidation-reduction process|testosterone biosynthetic process|,testosterone 17-beta-dehydrogenase (NADP+) activity|,10,-4.5,2.82,10,-1.2,0.949,-1.3,1.62,0.344,-8.2,1.2
ENSMUSG00000029131,DNAJB6,"DnaJ (Hsp40) homolog, subfamily B, member 6",nucleus|cytoplasm|cytosol|membrane|Z disc|perinuclear region of cytoplasm|,"protein folding|actin cytoskeleton organization|extracellular matrix organization|positive regulation of ATPase activity|protein localization to nucleus|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intermediate filament organization|negative regulation of transcription, DNA-templated|chorio-allantoic fusion|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|chorion development|negative regulation of inclusion body assembly|",ATPase activator activity|DNA binding|protein binding|heat shock protein binding|unfolded protein binding|chaperone binding|chaperone binding|,10,0,0,10,-5.7,3.62,-4.9,1.62,0.344,-10.8,0.4
ENSMUSG00000042772,SMG7,SMG7 nonsense mediated mRNA decay factor,nucleus|cytoplasm|cytosol|intermediate filament cytoskeleton|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA export from nucleus|gene expression|RNA metabolic process|mRNA metabolic process|regulation of dephosphorylation|",protein binding|protein phosphatase 2A binding|,0,0,0,1,-2.8,1.72,-2.8,1.61,0.346,-5,1.4
ENSMUSG00000069919,HBA-A1,"hemoglobin alpha, adult chain 1",hemoglobin complex|membrane|cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|extracellular vesicular exosome|blood microparticle|,in utero embryonic development|erythrocyte development|,peroxidase activity|haptoglobin binding|,9,-2.5,2.63,9,0,0,-1.4,1.61,0.346,-6,1.8
ENSMUSG00000031807,PGLS,6-phosphogluconolactonase,cytosol|extracellular vesicular exosome|,"carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|small molecule metabolic process|",6-phosphogluconolactonase activity|monosaccharide binding|,10,-2.9,1.3,10,-0.8,0.992,-1.3,1.61,0.346,-7.5,1.1
ENSMUSG00000024172,ST6GAL2,"ST6 beta-galactosamide alpha-2,6-sialyltranferase 2",integral component of membrane|Golgi cisterna membrane|,protein glycosylation|multicellular organismal development|oligosaccharide metabolic process|growth|sialylation|sialylation|,"beta-galactoside alpha-2,6-sialyltransferase activity|",10,-5,2.49,10,1.5,1.23,-4.6,1.61,0.346,-9.5,2.7
ENSMUSG00000070643,SOX13,SRY (sex determining region Y)-box 13,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|anatomical structure morphogenesis|",sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,0,0,0,1,-2.8,1.72,-2.8,1.61,0.346,-5,1.4
ENSMUSG00000049300,PRMT6,protein arginine methyltransferase 6,nucleus|cytosol|,"base-excision repair|transcription, DNA-templated|viral process|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|histone H3-R2 methylation|histone H4-R3 methylation|negative regulation of transcription, DNA-templated|",protein binding|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|histone binding|histone methyltransferase activity (H4-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H2A-R3 specific)|,10,0,0,10,-2.3,2.7,-2,1.61,0.346,-6.5,2.2
ENSMUSG00000024990,RBP4,"retinol binding protein 4, plasma",extracellular region|extracellular space|extracellular space|cytosol|protein complex|extracellular vesicular exosome|,"retinoid metabolic process|eye development|eye development|gluconeogenesis|gluconeogenesis|spermatogenesis|heart development|phototransduction, visible light|male gonad development|maintenance of gastrointestinal epithelium|lung development|positive regulation of insulin secretion|response to retinoic acid|response to insulin|retinol transport|retinol metabolic process|retinal metabolic process|glucose homeostasis|response to ethanol|embryonic organ morphogenesis|embryonic skeletal system development|cardiac muscle tissue development|female genitalia morphogenesis|detection of light stimulus involved in visual perception|positive regulation of immunoglobulin secretion|negative regulation of cardiac muscle cell proliferation|embryonic retina morphogenesis in camera-type eye|uterus development|vagina development|urinary bladder development|heart trabecula formation|",protein binding|retinal binding|retinol binding|retinol transporter activity|protein heterodimerization activity|,1,-3.3,1.72,0,0,0,-3.3,1.61,0.346,-7,1.2
ENSMUSG00000021567,NKD2,naked cuticle homolog 2 (Drosophila),cytoplasmic membrane-bounded vesicle|basolateral plasma membrane|lateral plasma membrane|cytoplasmic vesicle|cell periphery|,exocytosis|positive regulation of protein processing|Wnt signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|Golgi vesicle fusion to target membrane|protein targeting to plasma membrane|positive regulation of establishment of protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|,calcium ion binding|protein binding|growth factor binding|ubiquitin protein ligase binding|,0,0,0,1,-2.8,1.72,-2.8,1.61,0.346,-5,1.4
ENSMUSG00000028575,EQTN,"equatorin, sperm acrosome associated",inner acrosomal membrane|outer acrosomal membrane|early endosome|plasma membrane|integral component of membrane|,endocytosis|fusion of sperm to egg plasma membrane|acrosomal vesicle exocytosis|,None,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000029442,WDR66,WD repeat domain 66,None,None,calcium ion binding|,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000021904,SEMA3G,"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G",membrane|extracellular vesicular exosome|,multicellular organismal development|,receptor activity|,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000031774,FAM192A,"family with sequence similarity 192, member A",nucleus|,None,None,1,-2.1,0.793,1,-2.3,0.949,-2.3,1.6,0.348,-4,1.5
ENSMUSG00000035722,ABCA7,"ATP-binding cassette, sub-family A (ABC1), member 7",Golgi membrane|phagocytic cup|cytoplasm|Golgi apparatus|plasma membrane|plasma membrane|cell surface|endosome membrane|integral component of membrane|apical plasma membrane|ruffle membrane|ATP-binding cassette (ABC) transporter complex|,ATP catabolic process|ATP catabolic process|phagocytosis|memory|positive regulation of cholesterol efflux|phospholipid scrambling|peptide cross-linking|negative regulation of ATPase activity|positive regulation of ATPase activity|cholesterol efflux|phospholipid efflux|high-density lipoprotein particle assembly|protein localization to nucleus|apolipoprotein A-I-mediated signaling pathway|negative regulation of amyloid precursor protein biosynthetic process|positive regulation of phagocytosis|transmembrane transport|positive regulation of ERK1 and ERK2 cascade|positive regulation of beta-amyloid clearance|positive regulation of engulfment of apoptotic cell|negative regulation of beta-amyloid formation|positive regulation of phospholipid efflux|,transporter activity|ATP binding|phospholipid transporter activity|ATPase activity|apolipoprotein A-I receptor activity|,10,1.5,3.14,10,-0.6,0.664,1.2,1.6,0.348,-2.9,6.4
ENSMUSG00000031951,TMEM231,transmembrane protein 231,integral component of membrane|ciliary transition zone|TCTN-B9D complex|ciliary membrane|,smoothened signaling pathway|cilium assembly|,None,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000064280,CCDC146,coiled-coil domain containing 146,None,None,None,2,-4.3,1.71,0,0,0,-4.3,1.6,0.348,-9,4.3
ENSMUSG00000021696,ELOVL7,ELOVL fatty acid elongase 7,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,"fatty acid elongation, saturated fatty acid|triglyceride biosynthetic process|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|",protein binding|transferase activity|,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000006546,CRYBA2,"crystallin, beta A2",cellular_component|,lens development in camera-type eye|biological_process|,molecular_function|structural constituent of eye lens|protein homodimerization activity|,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000023963,CYP39A1,"cytochrome P450, family 39, subfamily A, polypeptide 1",endoplasmic reticulum membrane|intracellular membrane-bounded organelle|,bile acid biosynthetic process|bile acid biosynthetic process|cholesterol catabolic process|xenobiotic metabolic process|digestion|bile acid metabolic process|sterol metabolic process|bile acid catabolic process|small molecule metabolic process|oxidation-reduction process|,iron ion binding|steroid 7-alpha-hydroxylase activity|oxysterol 7-alpha-hydroxylase activity|heme binding|24-hydroxycholesterol 7alpha-hydroxylase activity|,0,0,0,1,2.5,1.71,2.5,1.6,0.348,-1.4,5
ENSMUSG00000064145,ARIH2,ariadne RBR E3 ubiquitin protein ligase 2,nucleus|cytoplasm|,protein polyubiquitination|multicellular organismal development|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|developmental cell growth|protein K63-linked ubiquitination|protein K48-linked ubiquitination|hematopoietic stem cell proliferation|,nucleic acid binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,10,-5.1,4.49,10,-0.2,0.0569,-4.9,1.59,0.349,-9.7,3.6
ENSMUSG00000026283,ING5,"inhibitor of growth family, member 5",nucleus|nucleoplasm|MOZ/MORF histone acetyltransferase complex|,"DNA replication|chromatin organization|transcription, DNA-templated|protein acetylation|negative regulation of cell proliferation|negative regulation of cell proliferation|positive regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription, DNA-templated|negative regulation of growth|positive regulation of apoptotic signaling pathway|",chromatin binding|protein binding|zinc ion binding|methylated histone binding|,10,-1.4,2.74,10,0,0,-1.1,1.59,0.349,-6,1.8
ENSMUSG00000022432,SMC1B,structural maintenance of chromosomes 1B,"chromosome, centromeric region|lateral element|meiotic cohesin complex|nuclear meiotic cohesin complex|",sister chromatid cohesion|meiotic nuclear division|,DNA binding|ATP binding|,10,-5.2,2.21,10,3.2,2.39,-4.9,1.59,0.349,-9.6,6
ENSMUSG00000025927,TFAP2B,transcription factor AP-2 beta (activating enhancer binding protein 2 beta),nucleus|nucleus|,"negative regulation of transcription from RNA polymerase II promoter|kidney development|renal water homeostasis|glucose metabolic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|positive regulation of cell proliferation|negative regulation of cell proliferation|response to lithium ion|retina layer formation|magnesium ion homeostasis|regulation of BMP signaling pathway|forelimb morphogenesis|hindlimb morphogenesis|positive regulation of urine volume|aorta morphogenesis|response to drug|glucose homeostasis|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|skin development|fat cell differentiation|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|sympathetic nervous system development|regulation of insulin secretion|phosphate ion homeostasis|calcium ion homeostasis|potassium ion homeostasis|sodium ion homeostasis|distal tubule development|collecting duct development|metanephric nephron development|ductus arteriosus closure|cellular ammonia homeostasis|cellular creatinine homeostasis|cellular urea homeostasis|",RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription corepressor activity|enhancer sequence-specific DNA binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein binding|protein homodimerization activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|sequence-specific DNA binding|protein heterodimerization activity|protein dimerization activity|,9,-2.3,0.646,10,-0.9,1.39,-0.9,1.58,0.351,-7.8,3.7
ENSMUSG00000020312,SHC2,SHC (Src homology 2 domain containing) transforming protein 2,cellular_component|cytosol|,Ras protein signal transduction|insulin receptor signaling pathway|neurotrophin TRK receptor signaling pathway|,protein binding|,10,-1.4,1.64,10,-0.5,0.248,-1.3,1.58,0.351,-4,5.7
ENSMUSG00000048076,ARF1,ADP-ribosylation factor 1,Golgi membrane|cytosol|plasma membrane|postsynaptic density|sarcomere|cell junction|neuron projection|postsynaptic membrane|perinuclear region of cytoplasm|extracellular vesicular exosome|,"regulation of receptor internalization|GTP catabolic process|phospholipid metabolic process|phosphatidylinositol biosynthetic process|cellular copper ion homeostasis|retrograde vesicle-mediated transport, Golgi to ER|post-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|protein transport|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of Arp2/3 complex-mediated actin nucleation|small molecule metabolic process|COPI coating of Golgi vesicle|regulation of defense response to virus by virus|long term synaptic depression|membrane organization|dendritic spine organization|",GTPase activity|receptor signaling protein activity|protein binding|GTP binding|poly(A) RNA binding|,0,0,0,1,2.5,1.67,2.5,1.57,0.353,-1.4,5
ENSMUSG00000038280,OSTM1,osteopetrosis associated transmembrane protein 1,nucleus|cytoplasm|lysosomal membrane|cytosol|integral component of membrane|intracellular membrane-bounded organelle|,osteoclast differentiation|ion transmembrane transport|transmembrane transport|,None,0,0,0,1,-2.8,1.68,-2.8,1.57,0.353,-5,1.4
ENSMUSG00000037306,MAN1C1,"mannosidase, alpha, class 1C, member 1",Golgi membrane|integral component of Golgi membrane|,protein N-linked glycosylation|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,"mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|",0,0,0,1,2.5,1.67,2.5,1.57,0.353,-1.4,5
ENSMUSG00000058997,VWA8,von Willebrand factor A domain containing 8,extracellular region|mitochondrion|,ATP catabolic process|,ATP binding|ATPase activity|,0,0,0,1,2.5,1.67,2.5,1.57,0.353,-1.4,5
ENSMUSG00000017221,PSMD3,"proteasome (prosome, macropain) 26S subunit, non-ATPase, 3",proteasome complex|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|proteasome accessory complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|regulation of protein catabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",enzyme regulator activity|,6,-2.9,2.29,7,2.5,2.18,2.1,1.57,0.353,-5.9,5.7
ENSMUSG00000049090,ZADH2,zinc binding alcohol dehydrogenase domain containing 2,mitochondrion|peroxisome|,biological_process|oxidation-reduction process|,molecular_function|zinc ion binding|oxidoreductase activity|,0,0,0,1,2.5,1.67,2.5,1.57,0.353,-1.4,5
ENSMUSG00000031986,SPRTN,SprT-like N-terminal domain,nucleus|chromosome|nuclear speck|,cellular response to DNA damage stimulus|response to UV|translesion synthesis|translesion synthesis|positive regulation of protein ubiquitination|,DNA binding|protein binding|ubiquitin binding|metal ion binding|K63-linked polyubiquitin binding|,1,-3.3,1.68,0,0,0,-3.3,1.57,0.353,-7,1.2
ENSMUSG00000029512,ULK1,unc-51 like autophagy activating kinase 1,cytoplasm|autophagic vacuole|cytosol|cytoplasmic vesicle membrane|pre-autophagosomal structure membrane|Atg1p signaling complex|neuron projection|neuronal cell body|ULK1-ATG13-FIP200 complex|,autophagic vacuole assembly|protein phosphorylation|Ras protein signal transduction|protein localization|regulation of autophagy|regulation of autophagy|positive regulation of autophagy|positive regulation of macroautophagy|cerebellar granule cell differentiation|radial glia guided migration of cerebellar granule cell|neuron projection regeneration|neuron projection development|receptor internalization|cellular response to nutrient levels|response to starvation|protein autophosphorylation|negative regulation of collateral sprouting|axon extension|regulation of neurotrophin TRK receptor signaling pathway|,protein serine/threonine kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|Rab GTPase binding|protein kinase binding|protein complex binding|,10,-1.8,0.493,10,-2,1.22,-1.9,1.57,0.353,-7.8,6.2
ENSMUSG00000027489,NECAB3,N-terminal EF-hand calcium binding protein 3,Golgi cis cisterna|nucleus|cytoplasm|endoplasmic reticulum membrane|,protein secretion|protein metabolic process|regulation of amyloid precursor protein biosynthetic process|,calcium ion binding|protein binding|,0,0,0,1,2.5,1.67,2.5,1.57,0.353,-1.4,5
ENSMUSG00000025784,CLEC3B,"C-type lectin domain family 3, member B",granular component|extracellular region|extracellular space|cytoplasm|extracellular matrix|extracellular vesicular exosome|,skeletal system development|ossification|positive regulation of plasminogen activation|bone mineralization|bone mineralization|cellular response to organic substance|cellular response to transforming growth factor beta stimulus|,calcium ion binding|heparin binding|carbohydrate binding|kringle domain binding|,9,1.2,2.37,9,0.2,0.0611,1,1.57,0.353,-3,4.5
ENSMUSG00000062762,EI24,etoposide induced 2.4,endoplasmic reticulum membrane|membrane|integral component of membrane|nuclear membrane|,autophagy|apoptotic process|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of cell growth|response to drug|neuromuscular process controlling balance|positive regulation of intrinsic apoptotic signaling pathway|,None,10,0.5,0.28,10,1.3,1.71,0.8,1.56,0.355,-1,2.9
ENSMUSG00000053626,TLL1,tolloid-like 1,extracellular region|,skeletal system development|proteolysis|extracellular matrix disassembly|cell differentiation|extracellular matrix organization|,metalloendopeptidase activity|calcium ion binding|collagen binding|zinc ion binding|,10,2.7,2.17,10,-1.4,1.21,-1.3,1.56,0.355,-5.4,5.2
ENSMUSG00000043421,HILPDA,hypoxia inducible lipid droplet-associated,extracellular space|lipid particle|cell surface|integral component of membrane|secretory granule|,positive regulation of cytokine production|response to stress|positive regulation of cell proliferation|positive regulation of lipid storage|autocrine signaling|,receptor binding|protein binding|,2,-2.2,1.66,0,0,0,-2.2,1.56,0.355,-4,1.5
ENSMUSG00000053199,ARHGAP20,Rho GTPase activating protein 20,cytosol|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,10,0,0,10,-1,1.81,-1,1.56,0.355,-5.4,2.4
ENSMUSG00000034312,IQSEC1,IQ motif and Sec7 domain 1,nucleolus|membrane|cell junction|intracellular membrane-bounded organelle|,actin cytoskeleton organization|regulation of ARF protein signal transduction|positive regulation of GTPase activity|positive regulation of GTPase activity|,ARF guanyl-nucleotide exchange factor activity|,0,0,0,2,1.8,1.66,1.8,1.56,0.355,-1.5,4
ENSMUSG00000062038,GM10108,"cytochrome c, somatic pseudogene",None,None,None,3,2.3,1.4,3,-1.7,1.3,-2.6,1.55,0.357,-6,4.7
ENSMUSG00000024892,PCX,pyruvate carboxylase,mitochondrion|mitochondrion|mitochondrial inner membrane|,pyruvate metabolic process|gluconeogenesis|oxaloacetate metabolic process|lipid metabolic process|metabolic process|,nucleotide binding|DNA binding|catalytic activity|biotin carboxylase activity|pyruvate carboxylase activity|ATP binding|biotin binding|ligase activity|carboxylic acid binding|metal ion binding|,10,-1,0.443,10,2.1,1.86,2.2,1.55,0.357,-2.2,6.7
ENSMUSG00000030726,POLD3,"polymerase (DNA-directed), delta 3, accessory subunit",nucleus|nucleoplasm|mitochondrion|delta DNA polymerase complex|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA synthesis involved in DNA repair|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|nucleotide-excision repair, DNA gap filling|mismatch repair|telomere maintenance via semi-conservative replication|",DNA-directed DNA polymerase activity|protein binding|,8,0.5,0.169,6,2,2.31,1.3,1.55,0.357,-2,5.9
ENSMUSG00000029603,DTX1,"deltex 1, E3 ubiquitin ligase",nucleus|cytoplasm|cytosol|,"transcription, DNA-templated|transcription from RNA polymerase II promoter|cell surface receptor signaling pathway|Notch signaling pathway|regulation of Notch signaling pathway|glial cell differentiation|protein ubiquitination|negative regulation of T cell differentiation|negative regulation of neuron differentiation|regulation of RNA biosynthetic process|",transcription coactivator activity|Notch binding|protein binding|zinc ion binding|ligase activity|SH3 domain binding|ubiquitin protein ligase binding|,10,-3,1.84,10,-1.2,0.677,-1.5,1.55,0.357,-9.3,6.7
ENSMUSG00000040594,RANBP17,RAN binding protein 17,nuclear pore|cytoplasm|,protein import into nucleus|mRNA transport|,GTP binding|Ran GTPase binding|,10,1.2,1.72,10,0.8,0.0249,1,1.55,0.357,-3.6,5
ENSMUSG00000038203,HOXA13,homeobox A13,nucleus|intermediate filament cytoskeleton|,"skeletal system development|vasculogenesis|endothelial cell morphogenesis|tissue homeostasis|ventricular septum development|transcription, DNA-templated|regulation of BMP signaling pathway|male genitalia development|embryonic forelimb morphogenesis|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|inner ear development|artery morphogenesis|branching involved in prostate gland morphogenesis|endothelial cell fate specification|positive regulation of mesenchymal cell apoptotic process|",DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,-2.3,1.16,10,-1.3,0.924,-2,1.54,0.359,-6.6,2.2
ENSMUSG00000024740,DDB1,"damage-specific DNA binding protein 1, 127kDa",extracellular space|nucleus|nucleoplasm|cytoplasm|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|extracellular vesicular exosome|Cul4-RING E3 ubiquitin ligase complex|,"nucleotide-excision repair, DNA damage removal|DNA repair|nucleotide-excision repair|viral process|Wnt signaling pathway|histone H2A monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|UV-damage excision repair|regulation of mitotic cell cycle phase transition|",DNA binding|damaged DNA binding|protein binding|,7,-1.4,1.06,5,-1.5,0.601,-1.4,1.54,0.359,-6.3,4.5
ENSMUSG00000086875,GM8975,predicted gene 8975,None,None,None,1,-3.3,1.65,0,0,0,-3.3,1.54,0.359,-6,1.3
ENSMUSG00000039055,EME1,essential meiotic structure-specific endonuclease 1,nucleus|nucleolus|cytoplasm|,DNA repair|DNA recombination|response to intra-S DNA damage checkpoint signaling|nucleic acid phosphodiester bond hydrolysis|,DNA binding|endonuclease activity|protein binding|metal ion binding|,10,-1.2,0.65,9,-1.3,1.02,-1.2,1.54,0.359,-5.7,5.6
ENSMUSG00000066828,VMN2R37,"vomeronasal 2, receptor 37",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,6,-3.2,0.703,7,5.4,3.72,5.3,1.54,0.359,-5.3,10.4
ENSMUSG00000096914,GALNTL6,polypeptide N-acetylgalactosaminyltransferase-like 6,Golgi membrane|integral component of membrane|,protein glycosylation|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,-3.1,0.888,10,-1.5,1.61,-2.7,1.54,0.359,-8.2,2.2
ENSMUSG00000095002,OLFR798,olfactory receptor 798,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,0,0,0,1,-2.7,1.64,-2.7,1.53,0.36,-5,1.4
ENSMUSG00000047897,RIPPLY2,ripply transcriptional repressor 2,nucleus|,ossification|somitogenesis|determination of left/right symmetry|somite rostral/caudal axis specification|post-anal tail morphogenesis|,None,10,7.1,3.93,10,-1.2,1.16,-1.2,1.53,0.36,-5.6,14.8
ENSMUSG00000022570,TSTA3,tissue specific transplantation antigen P35B,cytoplasm|extracellular vesicular exosome|,leukocyte cell-cell adhesion|GDP-mannose metabolic process|cytolysis|'de novo' GDP-L-fucose biosynthetic process|'de novo' GDP-L-fucose biosynthetic process|'de novo' GDP-L-fucose biosynthetic process|oxidation-reduction process|,electron carrier activity|isomerase activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|coenzyme binding|,9,-3.5,0.949,10,-1.1,0.941,-1.1,1.53,0.36,-6,7.5
ENSMUSG00000038437,MLLT6,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6",nucleus|,"regulation of transcription, DNA-templated|",protein binding|zinc ion binding|,10,-6.1,0.588,10,-1.5,1.99,-1,1.53,0.36,-10.1,3.2
ENSMUSG00000029030,TPRGL,transformation related protein 63 regulated like,synaptic vesicle|synaptic vesicle|cell junction|cytoplasmic vesicle|synapse|extracellular vesicular exosome|,biological_process|,protein binding|identical protein binding|,10,-2.2,0.949,10,-1.2,0.937,-1.4,1.53,0.36,-7.1,2.6
ENSMUSG00000001156,MXD1,MAX dimerization protein 1,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|multicellular organismal development|cell proliferation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription corepressor activity|protein dimerization activity|,0,0,0,1,2.4,1.64,2.4,1.53,0.36,-1.4,5
ENSMUSG00000032942,UCP3,"uncoupling protein 3 (mitochondrial, proton carrier)",mitochondrion|mitochondrial inner membrane|integral component of membrane|,response to superoxide|response to hypoxia|lipid metabolic process|fatty acid metabolic process|mitochondrial transport|aging|response to nutrient|respiratory gaseous exchange|response to cold|response to activity|proton transport|respiratory electron transport chain|response to insulin|cellular response to hormone stimulus|cellular metabolic process|small molecule metabolic process|response to glucocorticoid|,transporter activity|protein binding|oxidative phosphorylation uncoupler activity|,10,0.8,0.677,10,-2,2.03,-1.6,1.52,0.363,-5.8,2.5
ENSMUSG00000007815,RHOA,ras homolog family member A,cytosol|cytoskeleton|plasma membrane|cell cortex|lamellipodium|cell junction|midbody|cleavage furrow|apical junction complex|extracellular vesicular exosome|,GTP catabolic process|transforming growth factor beta receptor signaling pathway|small GTPase mediated signal transduction|Rho protein signal transduction|axon guidance|blood coagulation|viral process|substantia nigra development|actin cytoskeleton organization|platelet activation|regulation of cell migration|positive regulation of cytokinesis|regulation of osteoblast proliferation|cleavage furrow formation|positive regulation of NF-kappaB import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|apical junction assembly|ossification involved in bone maturation|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of axonogenesis|negative regulation of axonogenesis|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|trabecula morphogenesis|spindle assembly involved in mitosis|,GTPase activity|protein binding|GTP binding|myosin binding|,8,4.9,0.926,8,-1.5,1.04,-1.1,1.52,0.363,-6.8,8.8
ENSMUSG00000033405,NUDT15,nudix (nucleoside diphosphate linked moiety X)-type motif 15,cytosol|,GTP catabolic process|dGTP catabolic process|nucleobase-containing small molecule catabolic process|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,"8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|metal ion binding|",2,-2.1,1.62,0,0,0,-2.1,1.52,0.363,-4,1.5
ENSMUSG00000000827,TPD52L2,tumor protein D52-like 2,cytoplasm|perinuclear region of cytoplasm|,regulation of cell proliferation|,protein binding|protein homodimerization activity|poly(A) RNA binding|protein heterodimerization activity|,10,-0.4,0.118,10,-2.6,1.74,-2.1,1.52,0.363,-7.5,2.8
ENSMUSG00000021250,FOS,FBJ murine osteosarcoma viral oncogene homolog,nucleus|nucleoplasm|transcription factor complex|endoplasmic reticulum|cytosol|membrane|neuron projection|,"conditioned taste aversion|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|DNA methylation|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|inflammatory response|transforming growth factor beta receptor signaling pathway|nervous system development|female pregnancy|aging|response to cold|response to light stimulus|response to mechanical stimulus|response to gravity|response to toxic substance|sleep|cellular response to extracellular stimulus|response to lipopolysaccharide|response to progesterone|cellular response to hormone stimulus|response to cytokine|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|cellular response to reactive oxygen species|TRIF-dependent toll-like receptor signaling pathway|skeletal muscle cell differentiation|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|response to drug|innate immune response|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|response to corticosterone|response to cAMP|SMAD protein signal transduction|cellular response to calcium ion|",double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|R-SMAD binding|,10,-1,0.298,10,-1,1.33,-1,1.52,0.363,-7.4,4.1
ENSMUSG00000048387,OSR1,odd-skipped related transciption factor 1,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|urogenital system development|ureteric bud development|mesonephros development|chondrocyte differentiation|transcription, DNA-templated|heart development|gonad development|positive regulation of gene expression|cell differentiation|positive regulation of bone mineralization|negative regulation of epithelial cell differentiation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|intermediate mesoderm development|pronephros development|stem cell differentiation|positive regulation of epithelial cell proliferation|palate development|embryonic skeletal joint morphogenesis|cellular response to retinoic acid|metanephric mesenchyme development|cell proliferation involved in kidney development|metanephric mesenchyme morphogenesis|mesangial cell development|metanephric mesenchymal cell differentiation|posterior mesonephric tubule development|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|mesonephric duct morphogenesis|negative regulation of nephron tubule epithelial cell differentiation|renal vesicle progenitor cell differentiation|ureter urothelium development|metanephric epithelium development|metanephric smooth muscle tissue development|metanephric nephron tubule development|metanephric glomerulus vasculature development|metanephric interstitial cell development|pattern specification involved in metanephros development|embryonic skeletal joint development|metanephric cap mesenchymal cell proliferation involved in metanephros development|positive regulation of gastrulation|",nucleic acid binding|metal ion binding|,10,0,0,10,-5.6,3.08,-0.9,1.52,0.363,-11,3.5
ENSMUSG00000049336,TENM2,teneurin transmembrane protein 2,nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|PML body|cell junction|filopodium|dendrite|growth cone|neuron projection|dendritic spine|synapse|postsynaptic membrane|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|heterophilic cell-cell adhesion|signal transduction|axon guidance|single organismal cell-cell adhesion|calcium-mediated signaling using intracellular calcium source|positive regulation of filopodium assembly|",receptor binding|receptor binding|protein binding|protein homodimerization activity|protein heterodimerization activity|cell adhesion molecule binding|,10,-2.4,2.03,10,-0.7,0.576,-2.2,1.52,0.363,-5.4,1.2
ENSMUSG00000025551,FGF14,fibroblast growth factor 14,extracellular region|nucleus|,signal transduction|JNK cascade|cell-cell signaling|synaptic transmission|nervous system development|cell death|adult locomotory behavior|positive regulation of sodium ion transport|neuromuscular process|,growth factor activity|heparin binding|,10,-1.1,0.997,10,-0.9,0.689,-1,1.52,0.363,-5.1,4.5
ENSMUSG00000038845,PHB,prohibitin,nucleus|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|membrane|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|DNA replication|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|signal transduction|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|histone deacetylation|negative regulation of cell growth|regulation of apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|progesterone receptor signaling pathway|negative regulation of androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|cellular response to interleukin-6|DNA biosynthetic process|negative regulation of glucocorticoid receptor signaling pathway|",sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|enzyme binding|histone deacetylase binding|transcription regulatory region DNA binding|,3,-0.8,0.0919,6,-1.4,1.63,-1.3,1.51,0.365,-5,7.5
ENSMUSG00000041577,PRELP,proline/arginine-rich end leucine-rich repeat protein,extracellular region|proteinaceous extracellular matrix|Golgi lumen|extracellular matrix|extracellular matrix|lysosomal lumen|extracellular vesicular exosome|,skeletal system development|carbohydrate metabolic process|cell aging|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate catabolic process|small molecule metabolic process|,extracellular matrix structural constituent|heparin binding|,9,1.7,2.23,9,-2.3,1.03,1.4,1.51,0.365,-5.1,5
ENSMUSG00000020390,UBE2B,ubiquitin-conjugating enzyme E2B,chromatin|nuclear chromatin|XY body|nucleus|replication fork|cytoplasm|plasma membrane|HULC complex|,protein polyubiquitination|response to hypoxia|in utero embryonic development|DNA repair|postreplication repair|postreplication repair|maintenance of chromatin silencing|ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|spermatogenesis|sperm axoneme assembly|response to UV|positive regulation of reciprocal meiotic recombination|protein ubiquitination|cellular response to insulin stimulus|negative regulation of histone phosphorylation|histone H2A ubiquitination|response to drug|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of cAMP-mediated signaling|protein stabilization|chiasma assembly|protein autoubiquitination|canonical Wnt signaling pathway|histone lysine demethylation|synaptonemal complex organization|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|ubiquitin protein ligase binding|,10,-2.4,0.522,10,-1.5,1.13,-1.4,1.51,0.365,-7.2,1.4
ENSMUSG00000026872,ZEB2,zinc finger E-box binding homeobox 2,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|somitogenesis|neural tube closure|transcription, DNA-templated|nervous system development|hippocampus development|cell proliferation in forebrain|positive regulation of Wnt signaling pathway|positive regulation of JUN kinase activity|positive regulation of melanocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of melanin biosynthetic process|developmental pigmentation|melanocyte migration|regulation of melanosome organization|",sequence-specific DNA binding transcription factor activity|phosphatase regulator activity|sequence-specific DNA binding|metal ion binding|R-SMAD binding|,10,-3.3,2.26,10,-0.4,0.0022,-1.2,1.51,0.365,-6.5,3.1
ENSMUSG00000066568,LSM14A,"LSM14A, SCD6 homolog A (S. cerevisiae)",cytoplasmic mRNA processing body|cytoplasm|cytoplasmic stress granule|intracellular membrane-bounded organelle|,regulation of translation|multicellular organismal development|cytoplasmic mRNA processing body assembly|cytoplasmic mRNA processing body assembly|RIG-I signaling pathway|positive regulation of type I interferon-mediated signaling pathway|,double-stranded DNA binding|double-stranded RNA binding|single-stranded RNA binding|poly(A) RNA binding|,9,1.6,0.676,9,-2.7,2.67,-2.3,1.51,0.365,-7.1,3.7
ENSMUSG00000046411,GM6816,N/A,None,None,None,0,0,0,1,-2.7,1.6,-2.7,1.5,0.366,-5,1.4
ENSMUSG00000050668,GPATCH11,G patch domain containing 11,None,None,nucleic acid binding|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000030898,CCKBR,cholecystokinin B receptor,plasma membrane|integral component of plasma membrane|,gastric acid secretion|cell surface receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|digestion|sensory perception|feeding behavior|metabolic process|cell proliferation|positive regulation of cell proliferation|cholecystokinin signaling pathway|regulation of phosphatidylinositol 3-kinase activity|digestive tract development|gland development|,phosphatidylinositol phospholipase C activity|cholecystokinin receptor activity|protein binding|gastrin receptor activity|type B gastrin/cholecystokinin receptor binding|1-phosphatidylinositol-3-kinase regulator activity|,10,2.4,2.21,10,-0.3,0.113,-1.2,1.5,0.366,-5.5,4.7
ENSMUSG00000016833,MRPS18C,mitochondrial ribosomal protein S18C,mitochondrial small ribosomal subunit|,translation|,structural constituent of ribosome|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000032854,UGT8A,UDP galactosyltransferase 8A,intracellular|cell|membrane|integral component of membrane|,protein localization to paranode region of axon|lipid metabolic process|sphingolipid metabolic process|cytoskeleton organization|axon cargo transport|metabolic process|glycolipid biosynthetic process|paranodal junction assembly|myelination|neuron projection morphogenesis|,"2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|ceramide glucosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|transferase activity|transferase activity, transferring glycosyl groups|transferase activity, transferring hexosyl groups|",10,1.2,1.72,10,-3.3,4.15,-3.1,1.5,0.366,-8,2.6
ENSMUSG00000049044,RAPGEF4,Rap guanine nucleotide exchange factor (GEF) 4,cytosol|plasma membrane|cAMP-dependent protein kinase complex|membrane|,energy reserve metabolic process|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|blood coagulation|calcium ion-dependent exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|platelet activation|positive regulation of Ras GTPase activity|positive regulation of Ras GTPase activity|positive regulation of GTPase activity|small molecule metabolic process|regulation of protein kinase activity|regulation of insulin secretion|,guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|protein binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|cAMP binding|,1,-3.9,2.16,1,0,0,-3.7,1.5,0.366,-8,1.1
ENSMUSG00000025888,CASP1,"caspase 1, apoptosis-related cysteine peptidase",extracellular region|cytoplasm|cytosol|IPAF inflammasome complex|IPAF inflammasome complex|NLRP1 inflammasome complex|NLRP3 inflammasome complex|AIM2 inflammasome complex|,"response to hypoxia|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|response to lipopolysaccharide|interleukin-1 beta production|response to ATP|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of interleukin-1 alpha secretion|positive regulation of interleukin-1 beta secretion|regulation of inflammatory response|mitochondrial depolarization|membrane hyperpolarization|pyroptosis|cellular response to mechanical stimulus|cellular response to organic substance|execution phase of apoptosis|",endopeptidase activity|cysteine-type endopeptidase activity|cysteine-type endopeptidase activity|protein binding|cysteine-type endopeptidase activator activity involved in apoptotic process|,10,-0.4,0.166,10,-1.2,1.63,-1,1.5,0.366,-9,5.2
ENSMUSG00000031889,D230025D16RIK,RIKEN cDNA D230025D16 gene,trans-Golgi network|membrane|dendrite|synaptic vesicle membrane|,Golgi to plasma membrane protein transport|,receptor binding|glutamate receptor binding|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000030051,APLF,aprataxin and PNKP like factor,nucleus|cytosol|site of double-strand break|,"single strand break repair|DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|double-strand break repair|cellular response to DNA damage stimulus|positive regulation of DNA ligation|nucleic acid phosphodiester bond hydrolysis|",nucleotide binding|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|protein binding|3'-5' exonuclease activity|metal ion binding|,10,-3.5,0.845,10,-1,1.58,-1.2,1.5,0.366,-6.6,2.6
ENSMUSG00000021460,AUH,AU RNA binding protein/enoyl-CoA hydratase,mitochondrion|mitochondrial matrix|,leucine catabolic process|branched-chain amino acid catabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|,mRNA 3'-UTR binding|enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000028381,UGCG,UDP-glucose ceramide glucosyltransferase,Golgi membrane|membrane|integral component of membrane|,sphingolipid metabolic process|glucosylceramide biosynthetic process|glycosphingolipid metabolic process|glycosphingolipid biosynthetic process|epidermis development|small molecule metabolic process|,ceramide glucosyltransferase activity|,10,3.8,1.18,10,-2.2,1.76,-1.7,1.5,0.366,-6.9,6.7
ENSMUSG00000024423,IMPACT,impact RWD domain protein,cellular_component|cytoplasm|,negative regulation of protein phosphorylation|regulation of translational initiation|biological_process|,molecular_function|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000042197,ZFP451,zinc finger protein 451,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",DNA binding|metal ion binding|,0,0,0,1,-2.7,1.6,-2.7,1.5,0.366,-5,1.4
ENSMUSG00000009876,COX4I2,cytochrome c oxidase subunit IV isoform 2 (lung),mitochondrial respiratory chain complex IV|,generation of precursor metabolites and energy|cellular respiration|oxidation-reduction process|hydrogen ion transmembrane transport|hydrogen ion transmembrane transport|,cytochrome-c oxidase activity|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000019823,MICAL1,"microtubule associated monooxygenase, calponin and LIM domain containing 1",cytoplasm|intermediate filament|,negative regulation of protein phosphorylation|cytoskeleton organization|signal transduction|sulfur oxidation|actin filament depolymerization|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|oxidation-reduction process|,"actin binding|protein binding|zinc ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|SH3 domain binding|Rab GTPase binding|FAD binding|",0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000019647,SEMA6A,"sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A",integral component of plasma membrane|integral component of membrane|axon|,neuron migration|apoptotic process|cytoskeleton organization|cell surface receptor signaling pathway|nervous system development|axon guidance|axon guidance|organ morphogenesis|centrosome localization|semaphorin-plexin signaling pathway|positive regulation of neuron migration|,transmembrane signaling receptor activity|protein binding|semaphorin receptor binding|,0,0,0,1,2.4,1.6,2.4,1.5,0.366,-1.4,5
ENSMUSG00000018830,MYH11,"myosin, heavy chain 11, smooth muscle",stress fiber|cytosol|muscle myosin complex|smooth muscle contractile fiber|myosin filament|melanosome|,muscle contraction|smooth muscle contraction|axon guidance|metabolic process|skeletal muscle myosin thick filament assembly|elastic fiber assembly|cardiac muscle fiber development|,motor activity|protein binding|calmodulin binding|ATP binding|structural constituent of muscle|actin filament binding|,10,-1.1,0.816,10,-0.9,0.827,-1,1.49,0.369,-7,5.1
ENSMUSG00000041974,SPIDR,scaffolding protein involved in DNA repair,nuclear chromosome|,double-strand break repair via homologous recombination|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of protein complex assembly|regulation of establishment of protein localization to chromosome|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|positive regulation of double-strand break repair|,protein binding|,10,-2.1,1.55,10,1.3,1.31,-2.6,1.49,0.369,-8,3.1
ENSMUSG00000024590,LMNB1,lamin B1,nuclear envelope|nuclear inner membrane|lamin filament|nucleoplasm|membrane|nuclear membrane|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|,structural molecule activity|phospholipase binding|,10,1.2,2.77,10,-3.1,3.42,1,1.49,0.369,-8,2.9
ENSMUSG00000054612,MGMT,O-6-methylguanine-DNA methyltransferase,nucleus|nucleoplasm|membrane|,DNA ligation|DNA repair|DNA methylation|DNA dealkylation involved in DNA repair|response to toxic substance|cellular response to oxidative stress|response to drug|regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to ethanol|positive regulation of DNA repair|response to folic acid|negative regulation of cell death|mammary gland epithelial cell differentiation|cellular response to organic cyclic compound|cellular response to ionizing radiation|,DNA binding|methylated-DNA-[protein]-cysteine S-methyltransferase activity|calcium ion binding|methyltransferase activity|DNA-methyltransferase activity|,10,-1.8,2.27,10,2.5,1.62,-1.5,1.49,0.369,-6.8,5
ENSMUSG00000033306,LPP,LIM domain containing preferred translocation partner in lipoma,nucleus|cytoplasm|plasma membrane|focal adhesion|,cell adhesion|biological_process|,protein binding|zinc ion binding|,10,-1.1,2.52,10,0,0,-1.1,1.48,0.37,-12.7,2
ENSMUSG00000021038,VIPAS39,"VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",cytoplasm|early endosome|late endosome|cytoplasmic membrane-bounded vesicle|HOPS complex|recycling endosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular protein transport|spermatogenesis|endosome to lysosome transport|cell differentiation|",protein binding|,10,2,1.92,10,0.5,0.0801,1.5,1.48,0.37,-5.6,6
ENSMUSG00000030824,NUCB1,nucleobindin 1,extracellular space|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|membrane|extracellular vesicular exosome|,None,DNA binding|calcium ion binding|protein binding|,1,2.1,1.58,0,0,0,2.1,1.48,0.37,-1.4,5
ENSMUSG00000068921,DAP3,death associated protein 3,nucleus|nucleolus|mitochondrion|mitochondrial ribosome|small ribosomal subunit|,apoptotic mitochondrial changes|apoptotic signaling pathway|,protein binding|poly(A) RNA binding|,10,0.1,0.00122,10,1.2,1.71,1.1,1.47,0.372,-1.7,5.7
ENSMUSG00000034724,CNOT6L,"CCR4-NOT transcription complex, subunit 6-like",nucleus|cytoplasm|cytosol|CCR4-NOT complex|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translation|positive regulation of cell proliferation|gene expression|positive regulation of cytoplasmic mRNA processing body assembly|RNA metabolic process|mRNA metabolic process|gene silencing by RNA|mRNA destabilization|RNA phosphodiester bond hydrolysis, exonucleolytic|RNA phosphodiester bond hydrolysis, exonucleolytic|",poly(A)-specific ribonuclease activity|protein binding|metal ion binding|,9,1.9,1.13,9,-1.1,1.82,-1,1.47,0.372,-8.3,5.1
ENSMUSG00000020405,FABP6,"fatty acid binding protein 6, ileal",cytoplasm|cytosol|,lipid metabolic process|bile acid metabolic process|negative regulation of cell proliferation|bile acid and bile salt transport|small molecule metabolic process|,transporter activity|lipid binding|,1,-3.1,1.51,1,2.7,1.97,2.6,1.47,0.372,-5.4,5
ENSMUSG00000019820,UTRN,utrophin,nucleus|cytoplasm|cytoskeleton|plasma membrane|dystrophin-associated glycoprotein complex|membrane|cell junction|filopodium|filopodium membrane|neuromuscular junction|protein complex|postsynaptic membrane|extracellular vesicular exosome|contractile ring|,positive regulation of cell-matrix adhesion|muscle contraction|muscle organ development|regulation of sodium ion transmembrane transporter activity|,actin binding|integrin binding|calcium ion binding|protein binding|zinc ion binding|vinculin binding|protein kinase binding|,10,0.2,0.042,10,1.4,2.07,1.2,1.47,0.372,-2.5,5.1
ENSMUSG00000079679,VWDE,von Willebrand factor D and EGF domains,extracellular region|,None,None,1,-3.2,1.57,0,0,0,-3.2,1.47,0.372,-6,1.4
ENSMUSG00000015016,ACSF3,acyl-CoA synthetase family member 3,mitochondrion|,fatty acid metabolic process|fatty acid biosynthetic process|malonate catabolic process|,ATP binding|acid-thiol ligase activity|malonyl-CoA synthetase activity|,1,-3.8,2.11,1,1.7,0.834,-3.7,1.46,0.374,-7,3.2
ENSMUSG00000022055,NEFL,"neurofilament, light polypeptide",cytoplasm|cytosol|neurofilament|axon|TSC1-TSC2 complex|,synaptic transmission|anterograde axon cargo transport|retrograde axon cargo transport|cell death|axon transport of mitochondrion|neurofilament bundle assembly|neurofilament bundle assembly|intermediate filament organization|,"structural constituent of cytoskeleton|protein binding|protein C-terminus binding|protein binding, bridging|identical protein binding|",0,0,0,1,-2.7,1.56,-2.7,1.46,0.374,-5,1.4
ENSMUSG00000020871,DLX4,distal-less homeobox 4,nucleus|,"regulation of transcription, DNA-templated|multicellular organismal development|",transcription regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,1,-3.8,2.12,1,2.4,1.59,-3.7,1.46,0.374,-7,4.3
ENSMUSG00000025578,CBX8,chromobox homolog 8,nuclear chromatin|heterochromatin|nucleus|nucleoplasm|PcG protein complex|PRC1 complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|histone ubiquitination|",single-stranded RNA binding|ubiquitin-protein transferase activity|protein binding|methylated histone binding|,0,0,0,2,2.1,1.56,2.1,1.46,0.374,-1.4,5
ENSMUSG00000031765,MT1,metallothionein 1,intracellular|lysosome|cytosol|,cellular metal ion homeostasis|cellular zinc ion homeostasis|nitric oxide mediated signal transduction|detoxification of copper ion|negative regulation of neuron apoptotic process|cellular response to chromate|cellular response to zinc ion|,copper ion binding|zinc ion binding|metal ion binding|,0,0,0,1,2.4,1.56,2.4,1.46,0.374,-1.4,5
ENSMUSG00000024912,FOSL1,FOS-like antigen 1,nucleus|cytosol|presynaptic membrane|neuron projection|,in utero embryonic development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|chemotaxis|cellular defense response|vitellogenesis|female pregnancy|learning|positive regulation of cell proliferation|negative regulation of cell proliferation|response to mechanical stimulus|response to virus|response to gravity|cellular response to extracellular stimulus|response to progesterone|response to cytokine|response to drug|response to hydrogen peroxide|positive regulation of apoptotic process|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|response to corticosterone|response to cAMP|placenta blood vessel development|,RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,2.4,1.03,10,-1.5,1.35,-1,1.46,0.374,-4.5,6.2
ENSMUSG00000051998,LAX1,lymphocyte transmembrane adaptor 1,cytoplasm|Golgi apparatus|plasma membrane|membrane|integral component of membrane|,inactivation of MAPK activity|immune response|intracellular signal transduction|B cell activation|immunoglobulin secretion|antigen receptor-mediated signaling pathway|negative regulation of T cell activation|,protein binding|protein kinase binding|SH2 domain binding|,0,0,0,1,2.4,1.56,2.4,1.46,0.374,-1.4,5
ENSMUSG00000050567,MAML1,mastermind-like 1 (Drosophila),MAML1-RBP-Jkappa- ICN1 complex|nucleus|nucleoplasm|nuclear speck|intracellular membrane-bounded organelle|,atrioventricular node development|transcription initiation from RNA polymerase II promoter|protein phosphorylation|Notch signaling pathway|Notch signaling pathway|gene expression|positive regulation of myotube differentiation|myoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|atrioventricular node cell development|,transcription coactivator activity|protein binding|protein kinase binding|peptide antigen binding|,10,-2.6,1.36,10,-1.2,0.525,-2.3,1.46,0.374,-8.3,2.4
ENSMUSG00000020930,CCDC103,coiled-coil domain containing 103,cytoplasm|axoneme|,heart looping|cilium movement|cell projection organization|outer dynein arm assembly|inner dynein arm assembly|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|,protein homodimerization activity|,10,-1.9,1.86,10,-1,0.578,-1.6,1.46,0.374,-6.5,3.5
ENSMUSG00000048277,SYNGR2,synaptogyrin 2,synaptic vesicle|integral component of membrane|extracellular vesicular exosome|,protein targeting|,None,0,0,0,1,-2.7,1.56,-2.7,1.46,0.374,-5,1.4
ENSMUSG00000031659,ADCY7,adenylate cyclase 7,plasma membrane|plasma membrane|integral component of membrane|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|fibroblast growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|maternal process involved in female pregnancy|cellular response to ethanol|cellular response to glucagon stimulus|,adenylate cyclase activity|ATP binding|metal ion binding|,9,-2.7,2.69,10,1,1.04,-2.7,1.46,0.374,-8.3,4.1
ENSMUSG00000047415,GPR68,G protein-coupled receptor 68,plasma membrane|integral component of plasma membrane|,inflammatory response|G-protein coupled receptor signaling pathway|,G-protein coupled receptor activity|,0,0,0,1,2.4,1.56,2.4,1.46,0.374,-1.4,5
ENSMUSG00000032528,VIPR1,vasoactive intestinal peptide receptor 1,plasma membrane|integral component of plasma membrane|receptor complex|,"muscle contraction|immune response|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|synaptic transmission|digestion|positive regulation of cell proliferation|",vasoactive intestinal polypeptide receptor activity|protein binding|,10,-0.9,0.884,10,-1.4,0.807,-1.1,1.45,0.376,-5.9,2.6
ENSMUSG00000023905,TNFRSF12A,"tumor necrosis factor receptor superfamily, member 12A",ruffle|plasma membrane|cell surface|integral component of membrane|,"angiogenesis|apoptotic process|substrate-dependent cell migration, cell attachment to substrate|positive regulation of apoptotic process|positive regulation of axon extension|regulation of wound healing|positive regulation of extrinsic apoptotic signaling pathway|",protein binding|,10,-5,1.31,10,-1.1,1.15,-0.9,1.45,0.376,-8.7,1.8
ENSMUSG00000026125,PRSS39,"protease, serine 39",extracellular region|cytoplasmic vesicle|,proteolysis|,catalytic activity|serine-type endopeptidase activity|,10,-0.9,0.73,10,-1.7,1.04,-1.4,1.45,0.376,-5.6,1.7
ENSMUSG00000029026,TRP73,transformation related protein 73,chromatin|chromatin|nucleus|nucleus|transcription factor complex|cytoplasm|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|release of cytochrome c from mitochondria|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|inflammatory response|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle|cell cycle arrest|post-embryonic development|response to X-ray|response to gamma radiation|hippocampus development|forebrain development|mitotic G1 DNA damage checkpoint|cerebrospinal fluid secretion|cellular response to UV|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|negative regulation of JUN kinase activity|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|negative regulation of neuron differentiation|positive regulation of cell size|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|digestive tract morphogenesis|neuron development|positive regulation of oligodendrocyte differentiation|protein tetramerization|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic signaling pathway|",p53 binding|DNA binding|chromatin binding|damaged DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein kinase binding|identical protein binding|sequence-specific DNA binding|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding|,10,-2.9,3.87,10,0.5,0.0837,-2.7,1.45,0.376,-5.9,2.5
ENSMUSG00000030324,RHO,rhodopsin,photoreceptor outer segment|photoreceptor inner segment|Golgi apparatus|plasma membrane|integral component of plasma membrane|rough endoplasmic reticulum membrane|photoreceptor outer segment membrane|photoreceptor inner segment membrane|photoreceptor disc membrane|,"retinoid metabolic process|protein phosphorylation|G-protein coupled receptor signaling pathway|visual perception|phototransduction, visible light|red, far-red light phototransduction|rhodopsin mediated signaling pathway|protein-chromophore linkage|regulation of rhodopsin mediated signaling pathway|retina development in camera-type eye|",G-protein coupled receptor activity|protein binding|photoreceptor activity|retinal binding|metal ion binding|,10,-1,1.72,10,-0.4,0.0594,-0.8,1.45,0.376,-4,1.5
ENSMUSG00000021055,ESR2,estrogen receptor 2 (ER beta),extracellular region|nucleus|nucleus|nucleoplasm|mitochondrion|,"negative regulation of transcription from RNA polymerase II promoter|ovarian follicle development|neuron migration|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|brain development|hormone-mediated apoptotic signaling pathway|gene expression|negative regulation of cell growth|intracellular estrogen receptor signaling pathway|steroid hormone mediated signaling pathway|negative regulation of epithelial cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|uterus development|vagina development|prostate gland epithelium morphogenesis|epithelial cell maturation involved in prostate gland development|negative regulation of androgen receptor signaling pathway|extracellular negative regulation of signal transduction|",core promoter sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|steroid binding|steroid binding|protein binding|zinc ion binding|enzyme binding|estrogen receptor activity|estrogen response element binding|receptor antagonist activity|,10,-1,0.679,10,-0.8,0.897,-0.9,1.44,0.378,-4.2,1.5
ENSMUSG00000023495,PCBP4,poly(rC) binding protein 4,cytoplasm|ribonucleoprotein complex|,None,DNA binding|RNA binding|poly(A) RNA binding|,10,-3.9,2.5,10,-1.1,0.7,-1.2,1.44,0.378,-9.5,2
ENSMUSG00000024778,FAS,Fas cell surface death receptor,nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|plasma membrane|external side of plasma membrane|cell surface|integral component of membrane|death-inducing signaling complex|CD95 death-inducing signaling complex|membrane raft|extracellular vesicular exosome|,immunoglobulin production|renal system process|protein complex assembly|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation-induced cell death of T cells|inflammatory cell apoptotic process|transformed cell apoptotic process|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|response to toxic substance|B cell mediated immunity|positive regulation of protein homooligomerization|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative thymic T cell selection|regulation of lymphocyte differentiation|regulation of myeloid cell differentiation|spleen development|negative regulation of B cell activation|protein homooligomerization|response to glucocorticoid|cellular response to mechanical stimulus|cellular response to lithium ion|cellular response to hyperoxia|motor neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|necroptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|,signal transducer activity|receptor activity|transmembrane signaling receptor activity|protein binding|kinase binding|identical protein binding|,10,-1.6,0.865,10,-1.2,0.773,-1.4,1.44,0.378,-6.2,3.8
ENSMUSG00000031714,GAB1,GRB2-associated binding protein 1,cytosol|,response to oxidative stress|epidermal growth factor receptor signaling pathway|activation of JUN kinase activity|heart development|cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|epidermis development|regulation of cell migration|Fc-epsilon receptor signaling pathway|innate immune response|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|labyrinthine layer development|interleukin-6-mediated signaling pathway|,signal transducer activity|SH3/SH2 adaptor activity|protein binding|,10,1.2,0.184,10,-1.6,2.16,-1,1.44,0.378,-5.2,3.5
ENSMUSG00000041378,CLDN5,claudin 5,plasma membrane|cell-cell junction|tight junction|integral component of membrane|paranode region of axon|Schmidt-Lanterman incisure|extracellular vesicular exosome|,calcium-independent cell-cell adhesion|myelination|,structural molecule activity|identical protein binding|,10,1,1.33,10,-0.9,0.383,1.1,1.44,0.378,-2.8,5.1
ENSMUSG00000057667,BLOC1S3,"biogenesis of lysosomal organelles complex-1, subunit 3",cytosol|transport vesicle|BLOC-1 complex|,eye development|post-Golgi vesicle-mediated transport|anterograde axon cargo transport|platelet activation|neuron projection development|melanosome transport|melanosome organization|positive regulation of natural killer cell activation|secretion of lysosomal enzymes|endosome to melanosome transport|response to drug|pigmentation|anterograde synaptic vesicle transport|platelet dense granule organization|membrane organization|,molecular_function|protein binding|,10,-0.7,0.298,10,-1.5,1.36,-1,1.44,0.378,-7.6,2.8
ENSMUSG00000022949,CLIC6,chloride intracellular channel 6,cytoplasm|plasma membrane|chloride channel complex|extracellular vesicular exosome|,regulation of ion transmembrane transport|regulation of anion transport|chloride transmembrane transport|,voltage-gated chloride channel activity|protein C-terminus binding|D2 dopamine receptor binding|D3 dopamine receptor binding|D4 dopamine receptor binding|protein homodimerization activity|,10,-2.6,2.88,10,0.6,0.21,-2.3,1.44,0.378,-8.1,4.3
ENSMUSG00000090171,UGT1A2,"UDP glucuronosyltransferase 1 family, polypeptide A2",endoplasmic reticulum|membrane|integral component of membrane|intracellular membrane-bounded organelle|,metabolic process|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|,"retinoic acid binding|glucuronosyltransferase activity|transferase activity|transferase activity, transferring glycosyl groups|transferase activity, transferring hexosyl groups|enzyme binding|protein homodimerization activity|protein heterodimerization activity|",5,-6.7,3.31,5,1.2,0.764,-1.1,1.44,0.378,-12.8,3.9
ENSMUSG00000026167,WNT10A,"wingless-type MMTV integration site family, member 10A",extracellular region|proteinaceous extracellular matrix|extracellular space|,hair follicle development|positive regulation of gene expression|neural crest cell differentiation|Wnt signaling pathway|neuron differentiation|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentin-containing tooth|tongue development|skin development|cell fate commitment|epidermis morphogenesis|sebaceous gland development|cellular response to transforming growth factor beta stimulus|,frizzled binding|,10,-1,1.1,10,2.5,1.86,2.4,1.44,0.378,-5.2,8.1
ENSMUSG00000021234,FAM161B,"family with sequence similarity 161, member B",None,None,None,10,0,0,10,-1.5,1.87,-1.1,1.44,0.378,-6,2.4
ENSMUSG00000042207,KDM5B,lysine (K)-specific demethylase 5B,nucleus|,"transcription, DNA-templated|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|negative regulation of transcription, DNA-templated|oxidation-reduction process|","DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|zinc ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|",10,0.5,0.301,10,5.9,3.15,1.3,1.44,0.378,-1.5,11.4
ENSMUSG00000057406,WHSC1,Wolf-Hirschhorn syndrome candidate 1,nucleus|chromosome|nucleolus|cytoplasm|nuclear membrane|,"negative regulation of transcription from RNA polymerase II promoter|membranous septum morphogenesis|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|transcription, DNA-templated|anatomical structure morphogenesis|histone lysine methylation|bone development|",DNA binding|chromatin binding|protein binding|zinc ion binding|histone-lysine N-methyltransferase activity|,10,1,0.313,10,-4,3.52,-2.9,1.43,0.38,-8.7,3.4
ENSMUSG00000051146,CAMK2N2,calcium/calmodulin-dependent protein kinase II inhibitor 2,nucleus|cytosol|,negative regulation of protein kinase activity|,calcium-dependent protein kinase inhibitor activity|protein kinase binding|,10,6.2,4.8,10,-0.4,0.161,6.2,1.43,0.38,-1.4,13.3
ENSMUSG00000020601,TRIB2,tribbles pseudokinase 2,cytoplasm|cytoskeleton|,negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|negative regulation of interleukin-10 biosynthetic process|negative regulation of fat cell differentiation|,protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein transferase regulator activity|,1,2.1,1.53,0,0,0,2.1,1.43,0.38,-1.4,5
ENSMUSG00000079491,H2-T10,"histocompatibility 2, T region locus 10",None,inner ear development|,None,1,-3.1,1.53,0,0,0,-3.1,1.43,0.38,-6,1.4
ENSMUSG00000063558,AOX1,aldehyde oxidase 1,cytosol|extracellular vesicular exosome|,vitamin metabolic process|water-soluble vitamin metabolic process|inflammatory response|vitamin B6 metabolic process|small molecule metabolic process|oxidation-reduction process|reactive oxygen species metabolic process|,"aldehyde oxidase activity|xanthine dehydrogenase activity|iron ion binding|UDP-N-acetylmuramate dehydrogenase activity|electron carrier activity|molybdopterin cofactor binding|flavin adenine dinucleotide binding|NAD binding|2 iron, 2 sulfur cluster binding|",0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000045007,TUBG2,"tubulin, gamma 2",pericentriolar material|gamma-tubulin complex|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|microtubule cytoskeleton|,G2/M transition of mitotic cell cycle|mitotic cell cycle|GTP catabolic process|microtubule nucleation|cytoplasmic microtubule organization|protein polymerization|,GTPase activity|structural molecule activity|GTP binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000020876,SNX11,sorting nexin 11,endosome|membrane|,intracellular protein transport|vesicle organization|,phosphatidylinositol phosphate binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000043346,GM6741,haloacid dehalogenase-like hydrolase domain containing 4 pseudogene,None,None,None,9,-3.7,2.46,9,-1.1,0.92,-2.3,1.42,0.382,-8.7,6.8
ENSMUSG00000039774,GALNT12,polypeptide N-acetylgalactosaminyltransferase 12,Golgi membrane|integral component of membrane|,O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000026610,ESRRG,estrogen-related receptor gamma,nucleoplasm|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|gene expression|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|retinoic acid receptor signaling pathway|",steroid hormone receptor activity|retinoic acid receptor activity|steroid binding|protein binding|zinc ion binding|sequence-specific DNA binding|AF-2 domain binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000039632,CCDC151,coiled-coil domain containing 151,None,None,protein binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000024050,WIZ,widely interspaced zinc finger motifs,nucleus|extracellular vesicular exosome|,positive regulation of nuclear cell cycle DNA replication|protein stabilization|protein heterotrimerization|,protein binding|metal ion binding|,8,-2.3,1.13,9,-1.1,0.958,-1.9,1.42,0.382,-7,2.7
ENSMUSG00000058267,MRPS14,mitochondrial ribosomal protein S14,mitochondrion|mitochondrial ribosome|nuclear membrane|,translation|,structural constituent of ribosome|poly(A) RNA binding|,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000064138,FAM172A,"family with sequence similarity 172, member A",extracellular region|endoplasmic reticulum|,None,None,0,0,0,1,2.4,1.52,2.4,1.42,0.382,-1.4,5
ENSMUSG00000030713,KLK7,kallikrein-related peptidase 7,extracellular region|epidermal lamellar body|,proteolysis|epidermis development|extracellular matrix disassembly|extracellular matrix organization|,serine-type endopeptidase activity|serine-type peptidase activity|,10,-0.9,1.18,10,-0.6,0.42,-0.8,1.42,0.382,-11.2,7.1
ENSMUSG00000053719,KLK1B26,kallikrein 1-related petidase b26,extracellular space|nucleus|,brain renin-angiotensin system|proteolysis|zymogen activation|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,-4,0.804,10,-1,1.42,-1.7,1.42,0.382,-7,1.9
ENSMUSG00000003882,IL7R,interleukin 7 receptor,extracellular region|plasma membrane|external side of plasma membrane|integral component of membrane|,regulation of DNA recombination|cell morphogenesis|negative regulation of T cell mediated cytotoxicity|immunoglobulin production|immune response|signal transduction|cell surface receptor signaling pathway|regulation of cell size|positive regulation of gene expression|cell growth|T cell differentiation|positive regulation of T cell differentiation in thymus|interleukin-7-mediated signaling pathway|B cell proliferation|lymph node development|homeostasis of number of cells|,antigen binding|interleukin-7 receptor activity|protein binding|,10,1.2,1.56,10,-3.3,1.45,-3.1,1.42,0.382,-8.5,3.1
ENSMUSG00000063568,JAZF1,JAZF zinc finger 1,nucleus|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|",nucleic acid binding|transcription corepressor activity|metal ion binding|,10,1.4,1.88,10,-0.2,0.0604,-2.2,1.41,0.383,-6.8,4.2
ENSMUSG00000017300,TNNC2,troponin C type 2 (fast),cytosol|troponin complex|,skeletal muscle contraction|regulation of muscle contraction|muscle filament sliding|,actin binding|calcium ion binding|,10,-6.4,1.81,10,-0.6,0.332,-0.8,1.41,0.383,-11.1,2
ENSMUSG00000025558,DOCK9,dedicator of cytokinesis 9,cellular_component|cytosol|endomembrane system|membrane|,small GTPase mediated signal transduction|blood coagulation|biological_process|positive regulation of Rho GTPase activity|,Rho guanyl-nucleotide exchange factor activity|protein binding|Rho GTPase binding|,10,0,0,10,-5.9,4.12,-5.7,1.41,0.383,-11.6,0.9
ENSMUSG00000058013,11-Sep,septin 11,stress fiber|cell junction|axon|septin complex|dendritic spine|synapse|extracellular vesicular exosome|,cell cycle|protein heterooligomerization|cell division|,protein binding|GTP binding|,10,0.7,0.501,10,2.2,1.8,1.6,1.41,0.383,-2.7,5
ENSMUSG00000026815,GFI1B,growth factor independent 1B transcription repressor,nucleus|transcription factor complex|nuclear matrix|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|multicellular organismal development|cell proliferation|chromatin modification|,RNA polymerase II transcription factor binding|DNA binding|protein binding|metal ion binding|,10,-1.1,1.52,10,0.9,0.526,-1.5,1.4,0.385,-6,3.3
ENSMUSG00000041431,CCNB1,cyclin B1,spindle pole|condensed nuclear chromosome outer kinetochore|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|membrane|,regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle|oocyte maturation|in utero embryonic development|negative regulation of protein phosphorylation|protein complex assembly|protein phosphorylation|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|spermatogenesis|response to mechanical stimulus|negative regulation of gene expression|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of mRNA 3'-end processing|positive regulation of histone phosphorylation|tissue regeneration|response to drug|mitotic spindle stabilization|positive regulation of mitotic cell cycle|response to DDT|digestive tract development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cell cycle|positive regulation of attachment of spindle microtubules to kinetochore|ventricular cardiac muscle cell development|positive regulation of cardiac muscle cell proliferation|regulation of chromosome condensation|mitotic spindle checkpoint|cellular response to iron(III) ion|cellular response to fatty acid|cellular response to organic cyclic compound|cellular response to hypoxia|,patched binding|protein binding|kinase activity|protein kinase binding|,9,4.6,0.331,10,5,1.22,4.8,1.4,0.385,-3.3,10
ENSMUSG00000038811,GNGT2,"guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2",heterotrimeric G-protein complex|heterotrimeric G-protein complex|plasma membrane|,GTP catabolic process|GTP catabolic process|G-protein coupled receptor signaling pathway|synaptic transmission|phototransduction|,GTPase activity|GTPase activity|signal transducer activity|,0,0,0,3,1.3,1.5,1.3,1.4,0.385,-1.5,3
ENSMUSG00000038037,SOCS1,suppressor of cytokine signaling 1,nucleus|cytoplasm|cytosol|cytoplasmic membrane-bounded vesicle|,regulation of protein phosphorylation|negative regulation of protein kinase activity|JAK-STAT cascade|protein ubiquitination|cytokine-mediated signaling pathway|cytokine-mediated signaling pathway|regulation of growth|negative regulation of tyrosine phosphorylation of Stat3 protein|fat cell differentiation|negative regulation of JAK-STAT cascade|negative regulation of JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|cellular response to amino acid stimulus|,protein kinase inhibitor activity|insulin-like growth factor receptor binding|protein binding|kinase inhibitor activity|protein kinase binding|,10,1,1.84,9,-2.7,1.51,0.7,1.4,0.385,-5.6,3.9
ENSMUSG00000025056,NR0B1,"nuclear receptor subfamily 0, group B, member 1",nucleus|nucleoplasm|cytoplasm|membrane|polysomal ribosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|steroid biosynthetic process|spermatogenesis|protein localization|gonad development|male gonad development|gene expression|hypothalamus development|pituitary gland development|male sex determination|adrenal gland development|intracellular receptor signaling pathway|intracellular receptor signaling pathway|negative regulation of intracellular steroid hormone receptor signaling pathway|Leydig cell differentiation|response to immobilization stress|steroid hormone mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|Sertoli cell differentiation|",DNA binding|steroid hormone receptor activity|transcription corepressor activity|RNA binding|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|transcription factor binding|protein domain specific binding|DNA hairpin binding|steroid hormone receptor binding|protein homodimerization activity|sequence-specific DNA binding|AF-2 domain binding|,10,0,0,10,-1.1,1.53,-1.1,1.4,0.385,-8.1,2.4
ENSMUSG00000034201,GAS2L1,growth arrest-specific 2 like 1,stress fiber|stress fiber|cytoplasm|cytoplasm|microtubule|microtubule|,microtubule bundle formation|negative regulation of microtubule depolymerization|cell cycle arrest|cellular response to starvation|negative regulation of gene expression|negative regulation of cell growth|negative regulation of erythrocyte differentiation|regulation of cell cycle|cellular response to thyroid hormone stimulus|,microtubule binding|cytoskeletal adaptor activity|thyroid hormone receptor binding|,10,-2,0.484,10,-2.8,1.3,-2.3,1.4,0.385,-8.3,2.7
ENSMUSG00000007570,FANCE,"Fanconi anemia, complementation group E",nucleus|nucleoplasm|Fanconi anaemia nuclear complex|,DNA repair|,molecular_function|,10,-1.7,0.621,10,-3.1,1.73,-2.3,1.4,0.385,-7.9,2.7
ENSMUSG00000038453,SRCIN1,SRC kinase signaling inhibitor 1,cytoplasm|postsynaptic density|actin cytoskeleton|lamellipodium|filopodium|axon|dendrite|neuronal cell body|synapse|postsynaptic membrane|,exocytosis|negative regulation of cell adhesion|regulation of cell migration|substrate adhesion-dependent cell spreading|negative regulation of protein secretion|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|,protein binding|protein kinase binding|protein domain specific binding|,0,0,0,2,-2.8,1.49,-2.8,1.39,0.387,-5,3.4
ENSMUSG00000029385,CCNG2,cyclin G2,cytoplasm|,cell cycle checkpoint|mitotic nuclear division|regulation of cell cycle|,None,10,0,0,10,-2,2.62,-1.5,1.39,0.387,-5,3
ENSMUSG00000018322,TOMM34,translocase of outer mitochondrial membrane 34,nucleus|cytoplasm|mitochondrial outer membrane|membrane|integral component of membrane|,protein targeting to mitochondrion|,heat shock protein binding|,0,0,0,1,2.3,1.49,2.3,1.39,0.387,-1.5,5
ENSMUSG00000034833,TESPA1,"thymocyte expressed, positive selection associated 1",cytoplasm|endoplasmic reticulum membrane|COP9 signalosome|,COP9 signalosome assembly|positive regulation of T cell differentiation in thymus|positive regulation of T cell receptor signaling pathway|,receptor binding|,0,0,0,1,2.3,1.49,2.3,1.39,0.387,-1.5,5
ENSMUSG00000060244,ALYREF2,Aly/REF export factor 2,cellular_component|nucleus|spliceosomal complex|cytoplasm|,mRNA processing|transport|RNA splicing|mRNA transport|,nucleotide binding|nucleic acid binding|single-stranded DNA binding|RNA binding|,0,0,0,1,-2.7,1.48,-2.7,1.38,0.389,-5,1.4
ENSMUSG00000035234,FAM175A,"family with sequence similarity 175, member A",nucleus|BRCA1-A complex|,double-strand break repair|response to ionizing radiation|chromatin modification|G2 DNA damage checkpoint|positive regulation of DNA repair|,protein binding|polyubiquitin binding|,0,0,0,1,-2.7,1.48,-2.7,1.38,0.389,-5,1.4
ENSMUSG00000009471,MYOD1,myogenic differentiation 1,nuclear chromatin|nucleus|nucleoplasm|transcription factor complex|myofibril|,"regulation of alternative mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|protein phosphorylation|muscle organ development|myoblast fate determination|skeletal muscle tissue development|cellular response to starvation|myotube cell development|myotube differentiation involved in skeletal muscle regeneration|muscle cell differentiation|muscle cell fate commitment|positive regulation of skeletal muscle tissue regeneration|regulation of RNA splicing|skeletal muscle fiber adaptation|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle fiber development|positive regulation of muscle cell differentiation|positive regulation of muscle cell differentiation|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus|cellular response to oxygen levels|positive regulation of myoblast fusion|",RNA polymerase II regulatory region sequence-specific DNA binding|core promoter binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|chromatin DNA binding|ubiquitin protein ligase binding|nuclear hormone receptor binding|protein heterodimerization activity|E-box binding|,10,1.1,0.762,10,-1.4,1.32,-1.4,1.38,0.389,-6.6,2.5
ENSMUSG00000025135,ANAPC11,anaphase promoting complex subunit 11,nucleus|nucleoplasm|anaphase-promoting complex|nucleolus|cytosol|,mitotic cell cycle|mitotic nuclear division|mitotic spindle assembly checkpoint|protein ubiquitination|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|zinc ion binding|,2,-1.4,0.34,6,4.4,2.15,4.3,1.38,0.389,-1.6,9
ENSMUSG00000021952,XPO4,exportin 4,nucleus|cytoplasm|,protein transport|positive regulation of protein export from nucleus|,protein binding|,10,0.2,0.018,10,1.8,1.86,1.2,1.38,0.389,-1.9,4.5
ENSMUSG00000054728,PHACTR1,phosphatase and actin regulator 1,nucleus|cytosol|cell junction|synapse|,actomyosin structure organization|actin cytoskeleton reorganization|negative regulation of catalytic activity|stress fiber assembly|cell motility|,actin binding|protein phosphatase inhibitor activity|,10,3.5,1.24,9,1,0.752,1.1,1.38,0.389,-3.9,9
ENSMUSG00000024732,CCDC86,coiled-coil domain containing 86,nucleus|nucleolus|,viral process|,protein binding|poly(A) RNA binding|,0,0,0,1,-2.7,1.48,-2.7,1.38,0.389,-5,1.4
ENSMUSG00000031870,PGR,progesterone receptor,nucleoplasm|mitochondrial outer membrane|,ovulation from ovarian follicle|epithelial cell maturation|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|gene expression|negative regulation of gene expression|steroid hormone mediated signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of epithelial cell proliferation|progesterone receptor signaling pathway|tertiary branching involved in mammary gland duct morphogenesis|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|receptor binding|steroid binding|protein binding|zinc ion binding|enzyme binding|,10,2.5,2.57,10,-0.7,0.775,1.9,1.38,0.389,-5.9,8.2
ENSMUSG00000001566,MNX1,motor neuron and pancreas homeobox 1,nucleus|,"neuron migration|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|humoral immune response|motor neuron axon guidance|anatomical structure morphogenesis|post-embryonic development|spinal cord motor neuron cell fate specification|nerve development|dorsal/ventral neural tube patterning|endocrine pancreas development|diaphragm development|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,1.2,2.19,10,-0.2,0.0789,0.9,1.38,0.389,-6.6,4.3
ENSMUSG00000056486,CHN1,chimerin 1,cytosol|,small GTPase mediated signal transduction|motor neuron axon guidance|positive regulation of signal transduction|regulation of Rac GTPase activity|positive regulation of GTPase activity|ephrin receptor signaling pathway|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|,SH3/SH2 adaptor activity|GTPase activator activity|metal ion binding|ephrin receptor binding|,10,-0.7,1.02,10,-1.1,0.594,-0.9,1.38,0.389,-5.1,4.7
ENSMUSG00000020181,NAV3,neuron navigator 3,nuclear outer membrane|,metabolic process|,nucleotide binding|nucleoside-triphosphatase activity|,10,4.5,4.23,10,-1.3,1.86,4.4,1.37,0.391,-2.8,9.4
ENSMUSG00000023951,VEGFA,vascular endothelial growth factor A,extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular space|cytoplasm|cell surface|membrane|secretory granule|platelet alpha granule lumen|,negative regulation of transcription from RNA polymerase II promoter|angiogenesis|ovarian follicle development|patterning of blood vessels|vasculogenesis|response to hypoxia|in utero embryonic development|kidney development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of receptor internalization|basophil chemotaxis|platelet degranulation|positive regulation of leukocyte migration|heart morphogenesis|outflow tract morphogenesis|coronary vein morphogenesis|regulation of transcription from RNA polymerase II promoter|nervous system development|mesoderm development|lactation|blood coagulation|positive regulation of cell proliferation|regulation of cell shape|positive regulation of endothelial cell migration|positive regulation of gene expression|platelet activation|monocyte differentiation|macrophage differentiation|lung development|positive regulation of cell migration|epithelial cell differentiation|positive regulation of vascular endothelial growth factor receptor signaling pathway|post-embryonic camera-type eye development|positive regulation of protein complex assembly|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|tube formation|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|lymph vessel morphogenesis|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor signaling pathway|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|VEGF-activated neuropilin signaling pathway|growth|eye photoreceptor cell development|negative regulation of apoptotic process|positive regulation of vascular permeability|surfactant homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|cell maturation|camera-type eye morphogenesis|cardiac muscle fiber development|branching morphogenesis of an epithelial tube|positive regulation of axon extension involved in axon guidance|artery morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of positive chemotaxis|induction of positive chemotaxis|induction of positive chemotaxis|positive regulation of cellular component movement|positive regulation of cell division|positive regulation of focal adhesion assembly|primitive erythrocyte differentiation|mammary gland alveolus development|positive regulation of mast cell chemotaxis|cardiac vascular smooth muscle cell development|coronary artery morphogenesis|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of ERK1 and ERK2 cascade|cellular response to hypoxia|cellular response to hypoxia|dopaminergic neuron differentiation|commissural neuron axon guidance|positive regulation of protein kinase C signaling|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of branching involved in ureteric bud morphogenesis|regulation of retinal ganglion cell axon guidance|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of p38MAPK cascade|positive regulation of histone deacetylase activity|positive regulation of retinal ganglion cell axon guidance|positive regulation of intracellular signal transduction|positive regulation of protein localization to early endosome|,fibronectin binding|cytokine activity|cytokine activity|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor binding|protein binding|growth factor activity|growth factor activity|heparin binding|heparin binding|neuropilin binding|chemoattractant activity|identical protein binding|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|protein heterodimerization activity|receptor agonist activity|extracellular matrix binding|,10,1.8,1.88,10,-1.1,2.38,-0.8,1.37,0.391,-10.7,4.3
ENSMUSG00000032285,DNAJA4,"DnaJ (Hsp40) homolog, subfamily A, member 4",cytosol|membrane|,response to heat|protein refolding|negative regulation of inclusion body assembly|,ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding|chaperone binding|,9,1.2,0.876,10,-4.3,4.13,-4.2,1.37,0.391,-9.5,2.2
ENSMUSG00000098132,RASSF10,Ras association (RalGDS/AF-6) domain family (N-terminal) member 10,spindle pole|microtubule organizing center|cytosol|,signal transduction|,None,1,-3.1,1.46,0,0,0,-3.1,1.36,0.393,-6,1.4
ENSMUSG00000036904,FZD8,frizzled class receptor 8,cytoplasm|Golgi apparatus|plasma membrane|integral component of membrane|cell projection|,negative regulation of transcription from RNA polymerase II promoter|vasculature development|G-protein coupled receptor signaling pathway|axonogenesis|brain development|gonad development|neuron differentiation|T cell differentiation in thymus|positive regulation of JUN kinase activity|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|,G-protein coupled receptor activity|receptor binding|protein binding|Wnt-protein binding|PDZ domain binding|ubiquitin protein ligase binding|Wnt-activated receptor activity|Wnt-activated receptor activity|,9,-0.2,0.0746,9,-1,1.62,-1,1.36,0.393,-9.2,3.3
ENSMUSG00000075249,FSIP2,fibrous sheath interacting protein 2,None,None,None,10,-1.1,0.562,10,-2.9,1.66,-0.7,1.36,0.393,-8.2,2.2
ENSMUSG00000018362,KPNA2,"karyopherin alpha 2 (RAG cohort 1, importin alpha 1)",nucleus|nucleoplasm|cytoplasm|cytosol|membrane|,regulation of DNA recombination|mitotic G2 phase|DNA metabolic process|NLS-bearing protein import into nucleus|viral process|cytokine-mediated signaling pathway|,protein binding|nuclear localization sequence binding|protein transporter activity|histone deacetylase binding|poly(A) RNA binding|,7,0,0,6,-1.9,1.99,-1.2,1.36,0.393,-7.3,2.2
ENSMUSG00000040586,OFD1,oral-facial-digital syndrome 1,nucleus|centrosome|centriole|cytosol|cilium|microtubule cytoskeleton|membrane|centriolar satellite|ciliary basal body|,G2/M transition of mitotic cell cycle|mitotic cell cycle|cilium morphogenesis|epithelial cilium movement involved in determination of left/right asymmetry|,protein binding|alpha-tubulin binding|gamma-tubulin binding|,9,-1.7,0.822,10,-1.7,0.657,-1.7,1.36,0.393,-6.2,1.3
ENSMUSG00000015126,TSR3,"TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)",None,rRNA processing|,None,0,0,0,2,2.6,1.46,2.6,1.36,0.393,-4.4,5
ENSMUSG00000002459,RGS20,regulator of G-protein signaling 20,nucleus|cytoplasm|plasma membrane|,regulation of G-protein coupled receptor protein signaling pathway|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|positive regulation of GTPase activity|,GTPase activator activity|protein binding|,10,0.7,0.588,10,0.8,0.896,0.8,1.36,0.393,-2.1,3.9
ENSMUSG00000059060,RAD51B,RAD51 paralog B,nucleus|nucleoplasm|replication fork|Rad51B-Rad51C-Rad51D-XRCC2 complex|,double-strand break repair via homologous recombination|ATP catabolic process|ATP catabolic process|DNA repair|DNA recombination|reciprocal meiotic recombination|blood coagulation|positive regulation of G2/M transition of mitotic cell cycle|,four-way junction DNA binding|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|,10,2.1,3.62,9,-1,1.29,1.9,1.35,0.395,-6.5,5.7
ENSMUSG00000020218,WIF1,WNT inhibitory factor 1,extracellular region|,signal transduction|multicellular organismal development|Wnt signaling pathway|positive regulation of fat cell differentiation|,protein binding|,9,-0.6,0.218,10,-1.3,1.47,-1,1.35,0.395,-6,1.9
ENSMUSG00000069072,SLC7A14,"solute carrier family 7, member 14",integral component of membrane|,amino acid transmembrane transport|negative regulation of phosphatase activity|,amino acid transmembrane transporter activity|,0,0,0,1,2.3,1.45,2.3,1.35,0.395,-1.5,5
ENSMUSG00000068037,MAS1,"MAS1 proto-oncogene, G protein-coupled receptor",plasma membrane|integral component of plasma membrane|cell surface|,negative regulation of protein phosphorylation|G-protein coupled receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|spermatogenesis|cell proliferation|positive regulation of cell proliferation|male gonad development|anatomical structure morphogenesis|response to activity|hippocampus development|response to gonadotropin|angiotensin-activated signaling pathway|response to drug|positive regulation of DNA replication|regulation of inflammatory response|positive regulation of inositol phosphate biosynthetic process|protein kinase C signaling|cellular response to peptide hormone stimulus|,angiotensin receptor activity|G-protein coupled receptor activity|angiotensin type II receptor activity|peptide hormone binding|peptide binding|,10,0.7,0.568,10,-2,2.44,-1.2,1.34,0.397,-6.6,4.1
ENSMUSG00000035852,MISP,mitotic spindle positioning,cytoskeleton|focal adhesion|cell cortex|,mitotic nuclear division|,actin binding|,1,-2.7,1.17,1,-1.7,0.442,-2.5,1.34,0.397,-5,1.4
ENSMUSG00000079235,CCDC13,coiled-coil domain containing 13,None,None,None,1,0,0,2,-3,1.87,-3,1.34,0.397,-6,3.2
ENSMUSG00000062818,VMN1R51,vomeronasal 1 receptor 51,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|response to pheromone|,signal transducer activity|G-protein coupled receptor activity|pheromone receptor activity|,10,-1.8,1.77,10,-0.7,0.309,-1.5,1.34,0.397,-4.5,1.7
ENSMUSG00000038884,A230050P20RIK,RIKEN cDNA A230050P20 gene,cellular_component|,biological_process|,molecular_function|,10,-1.2,0.00695,10,-1.6,1.48,-1.3,1.34,0.397,-7.7,2.8
ENSMUSG00000020963,TSHR,thyroid stimulating hormone receptor,plasma membrane|integral component of plasma membrane|receptor complex|,"G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|cell-cell signaling|positive regulation of cell proliferation|thyroid-stimulating hormone signaling pathway|thyroid-stimulating hormone signaling pathway|",thyroid-stimulating hormone receptor activity|protein binding|,10,0.1,0.0147,10,-1.5,2.48,-1.6,1.34,0.397,-8,4.3
ENSMUSG00000024064,GALNT14,polypeptide N-acetylgalactosaminyltransferase 14,Golgi membrane|integral component of membrane|,O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,1,2,1.44,0,0,0,2,1.34,0.397,-1.5,5
ENSMUSG00000012483,RPA3,"replication protein A3, 14kDa",nucleoplasm|DNA replication factor A complex|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage removal|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|DNA replication|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|double-strand break repair|telomere maintenance via semi-conservative replication|",damaged DNA binding|single-stranded DNA binding|protein binding|,6,-2.1,1.22,5,1.6,0.52,-1.9,1.33,0.399,-4.8,3.9
ENSMUSG00000030083,ABTB1,ankyrin repeat and BTB (POZ) domain containing 1,nucleolus|cytoplasm|plasma membrane|,translational elongation|,translation elongation factor activity|,10,-1,1.02,10,-2.6,0.837,-0.7,1.33,0.399,-8.9,1.3
ENSMUSG00000036561,PPP6R2,"protein phosphatase 6, regulatory subunit 2",cytoplasm|intracellular membrane-bounded organelle|,None,protein binding|,9,-0.2,0.0866,10,-1.5,1.78,-0.9,1.33,0.399,-6.3,1.2
ENSMUSG00000040669,PHC1,polyhomeotic homolog 1 (Drosophila),sex chromatin|nucleus|nucleoplasm|nuclear body|PcG protein complex|PRC1 complex|,multicellular organismal development|histone ubiquitination|cellular response to retinoic acid|,DNA binding|chromatin binding|zinc ion binding|,10,-0.1,0.0116,10,-1.4,1.49,-1.5,1.33,0.399,-8.4,2.7
ENSMUSG00000020427,IGFBP3,insulin-like growth factor binding protein 3,extracellular region|extracellular region|extracellular space|nucleus|insulin-like growth factor binding protein complex|extracellular vesicular exosome|,regulation of cell growth|negative regulation of protein phosphorylation|protein phosphorylation|apoptotic process|negative regulation of cell proliferation|negative regulation of signal transduction|regulation of glucose metabolic process|negative regulation of smooth muscle cell migration|positive regulation of apoptotic process|positive regulation of catalytic activity|positive regulation of MAPK cascade|positive regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|type B pancreatic cell proliferation|positive regulation of myoblast differentiation|negative regulation of smooth muscle cell proliferation|,fibronectin binding|protein binding|insulin-like growth factor binding|protein tyrosine phosphatase activator activity|insulin-like growth factor I binding|metal ion binding|,10,-0.7,0.628,10,-1,0.848,-0.8,1.33,0.399,-8.5,5.4
ENSMUSG00000002870,MCM2,minichromosome maintenance complex component 2,chromatin|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytoplasm|microtubule cytoskeleton|MCM complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|nucleosome assembly|cell cycle|cellular response to interleukin-4|,DNA binding|DNA helicase activity|DNA replication origin binding|protein binding|ATP binding|histone binding|metal ion binding|,10,-4.9,0.58,10,1.8,1.42,1.8,1.32,0.401,-8.6,5.9
ENSMUSG00000028873,CDCA8,cell division cycle associated 8,"chromosome, centromeric region|nucleus|nucleolus|spindle|cytosol|chromocenter|midbody|chromosome passenger complex|protein complex|intercellular bridge|",mitotic metaphase|mitotic cell cycle|mitotic nuclear division|chromosome organization|,protein binding|,6,2.2,2.83,6,0.1,0.021,1.9,1.32,0.401,-2.9,6
ENSMUSG00000025650,COL7A1,"collagen, type VII, alpha 1",extracellular region|collagen type VII trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix|,cell adhesion|epidermis development|negative regulation of endopeptidase activity|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|,serine-type endopeptidase inhibitor activity|protein binding|identical protein binding|,10,-0.1,0.00529,10,-2.2,1.84,-1.1,1.32,0.401,-4.8,1.2
ENSMUSG00000052397,EZR,ezrin,ruffle|uropod|extracellular space|nucleolus|cytosol|cytosol|actin filament|plasma membrane|microvillus|focal adhesion|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|filopodium|T-tubule|cortical cytoskeleton|microvillus membrane|ruffle membrane|cell body|microspike|membrane raft|apical part of cell|cell tip|extracellular vesicular exosome|astrocyte projection|Schwann cell microvillus|,cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|axon guidance|regulation of cell shape|positive regulation of gene expression|membrane to membrane docking|receptor internalization|establishment or maintenance of apical/basal cell polarity|filopodium assembly|actin filament bundle assembly|establishment of endothelial barrier|,protein binding|protein domain specific binding|poly(A) RNA binding|cell adhesion molecule binding|actin filament binding|,10,1,1.49,10,-0.3,0.182,1,1.32,0.401,-7.5,5.3
ENSMUSG00000035049,RRP12,ribosomal RNA processing 12 homolog (S. cerevisiae),nucleolus|integral component of membrane|nuclear membrane|,None,poly(A) RNA binding|,1,2.2,1.8,1,-1.4,0.252,2.1,1.31,0.403,-1.5,5
ENSMUSG00000003500,IMPDH1,IMP (inosine 5'-monophosphate) dehydrogenase 1,nucleus|cytoplasm|cytosol|,purine nucleobase metabolic process|GMP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|small molecule metabolic process|lymphocyte proliferation|nucleobase-containing small molecule metabolic process|oxidation-reduction process|,nucleic acid binding|DNA binding|RNA binding|IMP dehydrogenase activity|adenyl nucleotide binding|metal ion binding|,10,2.4,2.03,10,-1.5,0.898,1.4,1.31,0.403,-5.1,5.5
ENSMUSG00000027654,FAM83D,"family with sequence similarity 83, member D",spindle pole|cytoplasm|,mitotic nuclear division|,None,1,-3,1.42,1,-1.4,0.254,-2.8,1.31,0.403,-6,1.3
ENSMUSG00000033585,NDN,"necdin, melanoma antigen (MAGE) family member",nucleus|centrosome|cytosol|cell projection|perikaryon|,"neuron migration|respiratory system process|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|axonal fasciculation|central nervous system development|negative regulation of cell proliferation|glial cell migration|post-embryonic development|sensory perception of pain|regulation of growth|neurotrophin TRK receptor signaling pathway|axon extension|multicellular organismal homeostasis|genetic imprinting|",DNA binding|gamma-tubulin binding|,10,-2.8,1.55,10,6.7,4.65,6.6,1.31,0.403,-4.4,14
ENSMUSG00000026202,TUBA4A,"tubulin, alpha 4a",extracellular region|cytosol|microtubule|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|platelet degranulation|GTP catabolic process|protein folding|microtubule-based process|blood coagulation|platelet activation|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|,10,5.5,1.78,10,-1,0.835,-1.4,1.31,0.403,-8.8,10.4
ENSMUSG00000038213,TAPBPL,TAP binding protein-like,endoplasmic reticulum membrane|plasma membrane|integral component of membrane|,negative regulation of antigen processing and presentation of peptide antigen via MHC class I|,protein complex binding|,0,0,0,1,2.3,1.41,2.3,1.31,0.403,-1.5,5
ENSMUSG00000046719,NXPH3,neurexophilin 3,extracellular region|,neuropeptide signaling pathway|,molecular_function|receptor binding|,0,0,0,1,2.3,1.41,2.3,1.31,0.403,-1.5,5
ENSMUSG00000029472,ANAPC5,anaphase promoting complex subunit 5,nucleus|nucleoplasm|anaphase-promoting complex|cytosol|,G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle|ubiquitin-dependent protein catabolic process|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|protein phosphatase binding|,6,-2.7,1.67,6,0.7,0.258,1.3,1.31,0.403,-5.4,4.8
ENSMUSG00000046000,NAA11,"N(alpha)-acetyltransferase 11, NatA catalytic subunit",nucleus|NatA complex|,N-terminal protein amino acid acetylation|,peptide alpha-N-acetyltransferase activity|protein binding|,0,0,0,1,2.3,1.41,2.3,1.31,0.403,-1.5,5
ENSMUSG00000050954,ZFP169,zinc finger protein 169,cellular_component|,biological_process|,molecular_function|metal ion binding|,1,-3,1.4,0,0,0,-3,1.3,0.405,-6,1.4
ENSMUSG00000071519,PRSS3,"protease, serine, 3",extracellular region|extracellular space|extracellular vesicular exosome|,proteolysis|proteolysis|vitamin metabolic process|water-soluble vitamin metabolic process|digestion|cobalamin metabolic process|zymogen activation|endothelial cell migration|small molecule metabolic process|innate immune response|,serine-type endopeptidase activity|calcium ion binding|protein binding|serine-type peptidase activity|,10,-1,0.285,9,-0.8,1.16,-0.9,1.3,0.405,-5.6,1.8
ENSMUSG00000037206,ISLR,immunoglobulin superfamily containing leucine-rich repeat,extracellular vesicular exosome|,cell adhesion|,None,1,-2,0.755,1,2.5,1.78,2.5,1.3,0.405,-3.4,5
ENSMUSG00000023175,BSG,basigin (Ok blood group),Golgi membrane|acrosomal membrane|mitochondrion|plasma membrane|integral component of plasma membrane|membrane|sarcolemma|melanosome|membrane raft|extracellular vesicular exosome|,pyruvate metabolic process|cell surface receptor signaling pathway|embryo implantation|blood coagulation|extracellular matrix disassembly|extracellular matrix organization|odontogenesis of dentin-containing tooth|response to peptide hormone|cellular metabolic process|small molecule metabolic process|response to mercury ion|decidualization|leukocyte migration|response to cAMP|protein targeting to plasma membrane|,protein binding|mannose binding|,10,1.2,1.24,10,2,0.225,1.2,1.3,0.405,-4.2,5.1
ENSMUSG00000032400,ZWILCH,zwilch kinetochore protein,kinetochore|condensed chromosome kinetochore|cytosol|,mitotic cell cycle|mitotic nuclear division|mitotic cell cycle checkpoint|,protein binding|,9,0.6,0.26,9,-1.2,2.29,-1.1,1.3,0.405,-4.7,2
ENSMUSG00000030745,IL21R,interleukin 21 receptor,integral component of membrane|,natural killer cell activation|interleukin-21-mediated signaling pathway|,interleukin-21 receptor activity|,10,0.2,0.0199,10,1.3,1.75,0.9,1.29,0.406,-5.8,6
ENSMUSG00000006471,NDOR1,NADPH dependent diflavin oxidoreductase 1,nucleus|cytoplasm|cytosol|intermediate filament cytoskeleton|perinuclear region of cytoplasm|,cell death|iron-sulfur cluster assembly|cellular response to menadione|small molecule metabolic process|oxidation-reduction process|,"NADPH-hemoprotein reductase activity|iron ion binding|protein binding|FMN binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|flavin adenine dinucleotide binding|NADP binding|",1,2.2,1.77,1,-1.4,0.273,2.1,1.29,0.406,-2.4,5
ENSMUSG00000043398,GPR135,G protein-coupled receptor 135,plasma membrane|integral component of membrane|,G-protein coupled receptor signaling pathway|,G-protein coupled receptor activity|,1,2,1.39,0,0,0,2,1.29,0.406,-1.5,5
ENSMUSG00000050043,TMX2,thioredoxin-related transmembrane protein 2,cellular_component|integral component of membrane|,biological_process|cell redox homeostasis|,molecular_function|,0,0,0,2,1.5,1.39,1.5,1.29,0.406,-1.6,3
ENSMUSG00000025776,CRISPLD1,cysteine-rich secretory protein LCCL domain containing 1,extracellular vesicular exosome|,face morphogenesis|,molecular_function|,9,-3.7,2.19,10,-0.4,0.0986,-1.5,1.29,0.406,-7.1,2.5
ENSMUSG00000017561,CRLF3,cytokine receptor-like factor 3,cytoplasm|,"G1/S transition of mitotic cell cycle|negative regulation of cell growth|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JAK-STAT cascade|positive regulation of cell cycle arrest|",None,1,2.2,1.77,1,-0.2,0.00727,2.1,1.29,0.406,-1.4,5
ENSMUSG00000063511,SNRNP70,small nuclear ribonucleoprotein 70kDa (U1),nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|nuclear speck|,"mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA processing|RNA splicing|gene expression|regulation of RNA splicing|",nucleotide binding|RNA binding|protein binding|poly(A) RNA binding|,1,2,1.39,0,0,0,2,1.29,0.406,-1.5,5
ENSMUSG00000071658,GNG3,"guanine nucleotide binding protein (G protein), gamma 3",heterotrimeric G-protein complex|plasma membrane|,activation of MAPK activity|energy reserve metabolic process|GTP catabolic process|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|synaptic transmission|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|,10,-1.2,2.59,10,0,0,-1,1.29,0.406,-4.4,2.3
ENSMUSG00000037236,MATR3,matrin 3,nucleus|nuclear inner membrane|membrane|nuclear matrix|,None,nucleotide binding|structural molecule activity|protein binding|zinc ion binding|poly(A) RNA binding|,9,1.9,2.46,10,-0.7,0.604,-1,1.29,0.406,-7.1,4.9
ENSMUSG00000004187,KIFC2,kinesin family member C2,cytoplasm|kinesin complex|microtubule|,microtubule-based movement|metabolic process|,microtubule motor activity|ATP binding|microtubule binding|,1,2,1.39,0,0,0,2,1.29,0.406,-1.5,5
ENSMUSG00000003555,CYP17A1,"cytochrome P450, family 17, subfamily A, polypeptide 1",mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|axon|neuronal cell body|,steroid biosynthetic process|androgen biosynthetic process|glucocorticoid biosynthetic process|xenobiotic metabolic process|sex differentiation|steroid metabolic process|steroid metabolic process|response to herbicide|response to acetate|response to ionizing radiation|sterol metabolic process|response to insecticide|biphenyl metabolic process|dibenzo-p-dioxin metabolic process|phenol-containing compound metabolic process|phthalate metabolic process|hippocampus development|adrenal gland development|ovulation|response to nutrient levels|response to retinoic acid|Leydig cell differentiation|response to cytokine|hormone biosynthetic process|progesterone metabolic process|response to drug|small molecule metabolic process|response to steroid hormone|response to cAMP|response to methylmercury|oxidation-reduction process|response to fungicide|cellular response to lipopolysaccharide|cellular response to antibiotic|cellular response to gonadotropin stimulus|positive regulation of steroid hormone biosynthetic process|,steroid 17-alpha-monooxygenase activity|iron ion binding|oxygen binding|heme binding|17-alpha-hydroxyprogesterone aldolase activity|,10,0,0,10,-0.9,1.91,-0.8,1.29,0.406,-6.9,1.6
ENSMUSG00000025816,SEC61A2,Sec61 alpha 2 subunit (S. cerevisiae),endoplasmic reticulum membrane|integral component of membrane|,"antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|biological_process|protein transport|antigen processing and presentation of exogenous peptide antigen via MHC class I|",molecular_function|ribosome binding|,0,0,0,1,2.2,1.37,2.2,1.28,0.409,-1.5,5
ENSMUSG00000031715,SMARCA5,"SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5",condensed chromosome|nucleus|nucleoplasm|chromatin silencing complex|NURF complex|RSF complex|nuclear replication fork|,"chromatin silencing at rDNA|ATP catabolic process|double-strand break repair|nucleosome assembly|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|embryo development|nucleosome positioning|centromere-specific nucleosome assembly|ATP-dependent chromatin remodeling|",DNA binding|helicase activity|protein binding|ATP binding|ATPase activity|nucleosome binding|histone binding|,9,0,0,10,-2.6,2.83,-2.7,1.28,0.409,-7.5,1.4
ENSMUSG00000018661,COG1,component of oligomeric golgi complex 1,Golgi membrane|Golgi apparatus|Golgi transport complex|Golgi transport complex|,intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|,protein binding|,0,0,0,1,2.2,1.37,2.2,1.28,0.409,-1.5,5
ENSMUSG00000055024,EP300,E1A binding protein p300,histone acetyltransferase complex|chromatin|nucleus|nucleoplasm|transcription factor complex|cytoplasm|protein-DNA complex|,"G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|response to hypoxia|somitogenesis|liver development|positive regulation of protein phosphorylation|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|internal protein amino acid acetylation|apoptotic process|Notch signaling pathway|nervous system development|heart development|skeletal muscle tissue development|circadian rhythm|response to glucose|organ morphogenesis|positive regulation of glycoprotein biosynthetic process|positive regulation of cell death|viral process|N-terminal peptidyl-lysine acetylation|internal peptidyl-lysine acetylation|lung development|response to cobalt ion|positive regulation of protein binding|positive regulation of type I interferon production|response to retinoic acid|positive regulation of collagen biosynthetic process|positive regulation of protein import into nucleus, translocation|response to tumor necrosis factor|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of DNA binding|protein kinase B signaling|response to estrogen|positive regulation by host of viral transcription|histone H4 acetylation|histone H2B acetylation|innate immune response|response to ethanol|positive regulation of translation|positive regulation of axon extension|positive regulation of cell size|positive regulation of proteolysis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|digestive tract development|positive regulation of protein secretion|positive regulation of sequence-specific DNA binding transcription factor activity|response to glucocorticoid|response to calcium ion|regulation of cell cycle|regulation of angiotensin metabolic process|positive regulation of sarcomere organization|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|protein-DNA complex assembly|cellular response to hydrogen peroxide|response to fatty acid|cellular response to organic cyclic compound|cellular response to hypoxia|regulation of tubulin deacetylation|","RNA polymerase II core promoter proximal region sequence-specific DNA binding|core promoter binding|RNA polymerase II activating transcription factor binding|p53 binding|DNA binding|chromatin binding|transcription coactivator activity|transcription coactivator activity|antigen binding|histone acetyltransferase activity|lysine N-acetyltransferase activity|protein binding|beta-catenin binding|transcription factor binding|zinc ion binding|acetyltransferase activity|acetyltransferase activity|transferase activity, transferring acyl groups|chromatin DNA binding|protein complex binding|activating transcription factor binding|nuclear hormone receptor binding|glucocorticoid receptor binding|peroxisome proliferator activated receptor binding|bHLH transcription factor binding|SMAD binding|androgen receptor binding|mitogen-activated protein kinase binding|NF-kappaB binding|",10,1.6,0.508,10,-1.5,1.8,-0.8,1.28,0.409,-7.2,4.3
ENSMUSG00000029217,TEC,transient erythroblastopenia of childhood,None,None,None,10,-3.1,2.6,10,2.6,0.439,-0.9,1.28,0.409,-6.2,3.8
ENSMUSG00000033220,RAC2,"ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)",nuclear envelope|cytosol|plasma membrane|extracellular vesicular exosome|,GTP catabolic process|signal transduction|small GTPase mediated signal transduction|axon guidance|blood coagulation|positive regulation of cell proliferation|regulation of hydrogen peroxide metabolic process|cell projection assembly|actin cytoskeleton organization|platelet activation|bone resorption|regulation of small GTPase mediated signal transduction|regulation of respiratory burst|,GTPase activity|GTP binding|,9,-1.7,1.2,9,-1.1,0.418,-1.3,1.28,0.409,-8.2,3
ENSMUSG00000061046,HAGHL,hydroxyacylglutathione hydrolase-like,None,metabolic process|,hydrolase activity|metal ion binding|,10,1.2,1.04,10,-1.4,1.84,-1.5,1.28,0.409,-6.4,3
ENSMUSG00000051920,RSPO2,R-spondin 2,extracellular region|cell surface|,osteoblast differentiation|Wnt signaling pathway|bone mineralization|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|lung growth|epithelial tube branching involved in lung morphogenesis|trachea cartilage morphogenesis|positive regulation of canonical Wnt signaling pathway|,receptor binding|heparin binding|,0,0,0,1,2.2,1.37,2.2,1.28,0.409,-1.5,5
ENSMUSG00000028176,LRRC7,leucine rich repeat containing 7,cytoplasm|postsynaptic density|cell junction|postsynaptic membrane|,None,protein binding|,10,-2.4,0.85,10,-0.8,0.604,-0.9,1.28,0.409,-7.7,2.4
ENSMUSG00000003348,MOB3A,MOB kinase activator 3A,intracellular|,None,metal ion binding|,10,0.4,0.134,10,0.9,1.4,0.8,1.27,0.411,-6.3,5.6
ENSMUSG00000040177,2310057M21RIK,RIKEN cDNA 2310057M21 gene,cellular_component|,biological_process|,identical protein binding|,0,0,0,1,-2.6,1.36,-2.6,1.27,0.411,-5,1.5
ENSMUSG00000001120,PCBP3,poly(rC) binding protein 3,nucleus|cytosol|ribonucleoprotein complex|,mRNA metabolic process|,DNA binding|RNA binding|poly(A) RNA binding|,0,0,0,2,1.5,1.36,1.5,1.27,0.411,-1.6,3
ENSMUSG00000034120,SRSF2,serine/arginine-rich splicing factor 2,nucleus|nucleoplasm|nuclear speck|extracellular vesicular exosome|,"mRNA splicing, via spliceosome|transcription from RNA polymerase II promoter|termination of RNA polymerase II transcription|mRNA processing|mRNA export from nucleus|RNA splicing|gene expression|mRNA 3'-end processing|regulation of RNA biosynthetic process|",nucleotide binding|transcription corepressor activity|protein binding|poly(A) RNA binding|,0,0,0,1,-2.6,1.36,-2.6,1.27,0.411,-5,1.5
ENSMUSG00000021377,DEK,DEK proto-oncogene,nucleus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|signal transduction|chromatin modification|viral genome replication|regulation of double-strand break repair|regulation of double-strand break repair via nonhomologous end joining|,DNA binding|histone binding|poly(A) RNA binding|,10,-4.4,2.13,10,-0.3,0.124,-0.9,1.27,0.411,-8.1,1.7
ENSMUSG00000059540,TCEA2,"transcription elongation factor A (SII), 2",nucleus|centrosome|transcription elongation factor complex|,"DNA-templated transcription, elongation|regulation of DNA-templated transcription, elongation|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|protein binding|zinc ion binding|,10,-0.7,0.831,10,-1.7,0.889,-1.1,1.27,0.411,-6.5,2.5
ENSMUSG00000013973,DEDD,death effector domain containing,nucleolus|cytoplasm|,"transcription, DNA-templated|spermatogenesis|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of protein catabolic process|regulation of apoptotic process|decidualization|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|",DNA binding|protein binding|,10,1.7,0.793,10,-0.8,1.23,-0.7,1.27,0.411,-9.1,3.1
ENSMUSG00000017390,ALDOC,"aldolase C, fructose-bisphosphate",mitochondrion|cytosol|cytoskeleton|axon|extracellular vesicular exosome|,"response to hypoxia|carbohydrate metabolic process|fructose metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|apoptotic process|aging|response to organonitrogen compound|response to organic cyclic compound|fructose 1,6-bisphosphate metabolic process|epithelial cell differentiation|organ regeneration|small molecule metabolic process|protein homotetramerization|protein heterotetramerization|",fructose-bisphosphate aldolase activity|protein binding|cytoskeletal protein binding|,9,1.7,1.63,10,-3.7,0.793,1.5,1.27,0.411,-7.6,5.7
ENSMUSG00000014776,NOL3,nucleolar protein 3 (apoptosis repressor with CARD domain),nucleolus|mitochondrion|cytosol|sarcoplasm|,mRNA processing|apoptotic process|RNA splicing|negative regulation of apoptotic process|,RNA binding|protein binding|identical protein binding|,10,-0.8,0.181,10,-1.3,1.21,-1.3,1.27,0.411,-6.1,2.4
ENSMUSG00000026319,2310035C23RIK,RIKEN cDNA 2310035C23 gene,cellular_component|,biological_process|,molecular_function|,1,-2.9,1.35,0,0,0,-2.9,1.26,0.413,-6,1.4
ENSMUSG00000028785,HPCA,hippocalcin,None,inner ear development|,actin binding|calcium ion binding|,10,0,0,10,-2.9,2.36,-0.7,1.26,0.413,-8.5,1.8
ENSMUSG00000022945,CHAF1B,"chromatin assembly factor 1, subunit B (p60)",nuclear chromatin|nucleus|nucleus|nucleoplasm|cytoplasm|cytosol|CAF-1 complex|protein complex|,"DNA replication|DNA repair|DNA replication-dependent nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|cell cycle|chromatin assembly|",chromatin binding|histone binding|unfolded protein binding|,7,-1.9,1.64,8,-0.7,0.251,-1.5,1.26,0.413,-5,4.6
ENSMUSG00000040212,EMP3,epithelial membrane protein 3,integral component of membrane|,negative regulation of cell proliferation|cell growth|,None,10,-1.3,0.354,10,-0.9,1.08,-1.1,1.26,0.413,-4.8,3.3
ENSMUSG00000020673,TPO,thyroid peroxidase,extracellular space|mitochondrion|plasma membrane|integral component of plasma membrane|cell surface|,thyroid hormone generation|thyroid hormone generation|cellular nitrogen compound metabolic process|embryonic hemopoiesis|hormone biosynthetic process|hydrogen peroxide catabolic process|small molecule metabolic process|oxidation-reduction process|,iodide peroxidase activity|peroxidase activity|calcium ion binding|heme binding|,10,-2.6,3.19,10,-0.2,0.0671,-2.3,1.26,0.413,-8.6,2.6
ENSMUSG00000090083,RNF8,"ring finger protein 8, E3 ubiquitin protein ligase","ubiquitin ligase complex|chromosome, telomeric region|nucleus|nucleolus|midbody|site of double-strand break|",double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|mitotic nuclear division|spermatid development|response to ionizing radiation|histone H2A ubiquitination|histone H2B ubiquitination|interstrand cross-link repair|histone exchange|isotype switching|positive regulation of DNA repair|negative regulation of translational elongation|protein autoubiquitination|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination|histone H2A K63-linked ubiquitination|protein K48-linked ubiquitination|,chromatin binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|acid-amino acid ligase activity|ubiquitin protein ligase binding|histone binding|protein homodimerization activity|,1,-3.5,1.88,1,0,0,-3.4,1.26,0.413,-7,1.2
ENSMUSG00000038965,UBE2L3,ubiquitin-conjugating enzyme E2L 3,ubiquitin ligase complex|nucleus|cytoplasm|extracellular vesicular exosome|,"protein polyubiquitination|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell proliferation|protein ubiquitination|protein K11-linked ubiquitination|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|",transcription coactivator activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|enzyme binding|ubiquitin protein ligase binding|poly(A) RNA binding|,1,1,0.337,4,3.1,1.38,3,1.26,0.413,-2.5,6.7
ENSMUSG00000055010,A830031A19RIK,RIKEN cDNA A830031A19 gene,cellular_component|,biological_process|,molecular_function|,2,-1.6,1.35,0,0,0,-1.6,1.26,0.413,-3,1.6
ENSMUSG00000020271,FBXW11,F-box and WD repeat domain containing 11,ubiquitin ligase complex|nucleus|centrosome|cytosol|cytosol|SCF ubiquitin ligase complex|,"G2/M transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|protein dephosphorylation|Wnt signaling pathway|protein ubiquitination|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|negative regulation of NF-kappaB import into nucleus|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|rhythmic process|",ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|protein dimerization activity|,9,1.7,0.965,9,4.9,1.52,2.4,1.25,0.415,-1.8,9.7
ENSMUSG00000068220,LGALS1,"lectin, galactoside-binding, soluble, 1",proteinaceous extracellular matrix|extracellular space|intracellular|nucleus|cytoplasm|cell surface|extracellular matrix|extracellular matrix|extracellular vesicular exosome|,plasma cell differentiation|apoptotic process|signal transduction|negative regulation of cell-substrate adhesion|negative regulation of neuron projection development|T cell costimulation|multicellular organismal response to stress|positive regulation of erythrocyte aggregation|response to drug|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|myoblast differentiation|response to axon injury|cellular response to glucose stimulus|cellular response to organic cyclic compound|,glycoprotein binding|signal transducer activity|protein binding|galactoside binding|lactose binding|protein homodimerization activity|laminin binding|poly(A) RNA binding|,10,-6,1.15,10,-1.1,0.516,-0.8,1.25,0.415,-10.4,2.5
ENSMUSG00000028356,AMBP,alpha-1-microglobulin/bikunin precursor,extracellular region|extracellular region|extracellular space|plasma membrane|cell surface|intracellular membrane-bounded organelle|extracellular vesicular exosome|blood microparticle|,cell adhesion|female pregnancy|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|viral process|protein-chromophore linkage|protein catabolic process|heme catabolic process|negative regulation of JNK cascade|negative regulation of immune response|,serine-type endopeptidase inhibitor activity|protein binding|calcium channel inhibitor activity|IgA binding|heme binding|small molecule binding|protein homodimerization activity|calcium oxalate binding|,10,-1.4,0.616,10,2.6,1.17,-1.4,1.25,0.415,-4.5,4.8
ENSMUSG00000011958,BNIP2,BCL2/adenovirus E1B 19kDa interacting protein 2,nuclear envelope|cytoplasm|cytosol|cytosol|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,apoptotic process|muscle cell differentiation|negative regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of muscle cell differentiation|,GTPase activator activity|calcium ion binding|protein binding|identical protein binding|,10,1.7,0.837,10,-1.1,1.21,1.3,1.25,0.415,-4.4,5.4
ENSMUSG00000046070,IGFALS,"insulin-like growth factor binding protein, acid labile subunit",extracellular region|extracellular region|extracellular space|nucleus|extracellular vesicular exosome|,cell adhesion|signal transduction|cellular protein metabolic process|,insulin-like growth factor binding|,10,-1.2,0.8,10,-1.3,0.56,-1.3,1.25,0.415,-6.1,1.5
ENSMUSG00000018168,IKZF3,IKAROS family zinc finger 3 (Aiolos),nucleus|cytoplasm|plasma membrane|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mesoderm development|regulation of B cell proliferation|B cell activation|regulation of apoptotic process|regulation of B cell differentiation|regulation of lymphocyte differentiation|",sequence-specific DNA binding transcription factor activity|protein binding|protein homodimerization activity|sequence-specific DNA binding|metal ion binding|protein heterodimerization activity|,10,6,4.45,10,-0.7,0.605,6,1.25,0.415,-4.5,12.8
ENSMUSG00000029556,HNF1A,HNF1 homeobox A,nucleus|cytoplasm|protein complex|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|insulin secretion|renal glucose absorption|glucose homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|glucose import|positive regulation of transcription initiation from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|protein dimerization activity|,10,-0.5,0.376,10,-1.5,1.57,-1.3,1.25,0.415,-5.7,2.5
ENSMUSG00000043019,EDEM3,"ER degradation enhancer, mannosidase alpha-like 3",endoplasmic reticulum lumen|endoplasmic reticulum membrane|,protein folding|glycoprotein catabolic process|response to unfolded protein|protein N-linked glycosylation via asparagine|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|cellular protein metabolic process|,"glycoprotein endo-alpha-1,2-mannosidase activity|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|",0,0,0,1,2.2,1.33,2.2,1.24,0.418,-1.6,4
ENSMUSG00000035456,PRDM8,PR domain containing 8,nucleus|,"transcription, DNA-templated|corpus callosum morphogenesis|corticospinal tract morphogenesis|negative regulation of transcription, DNA-templated|histone H3-K9 methylation|",DNA binding|chromatin binding|transcription corepressor activity|metal ion binding|histone methyltransferase activity (H3-K9 specific)|,0,0,0,1,-2.6,1.33,-2.6,1.24,0.418,-5,1.5
ENSMUSG00000016918,SULF1,sulfatase 1,extracellular space|extracellular space|endoplasmic reticulum|Golgi apparatus|Golgi stack|plasma membrane|cell surface|membrane raft|,kidney development|negative regulation of endothelial cell proliferation|chondrocyte development|glomerular filtration|apoptotic process|positive regulation vascular endothelial growth factor production|esophagus smooth muscle contraction|negative regulation of angiogenesis|positive regulation of Wnt signaling pathway|heparan sulfate proteoglycan metabolic process|heparan sulfate proteoglycan metabolic process|negative regulation of cell migration|positive regulation of BMP signaling pathway|glomerular basement membrane development|glial cell-derived neurotrophic factor receptor signaling pathway|regulation of fibroblast growth factor receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|embryonic skeletal system development|cartilage development|bone development|innervation|negative regulation of prostatic bud formation|,arylsulfatase activity|arylsulfatase activity|calcium ion binding|N-acetylglucosamine-6-sulfatase activity|N-acetylglucosamine-6-sulfatase activity|,10,-2.5,0.997,10,-1.3,1.09,-1.5,1.24,0.418,-7.3,3.5
ENSMUSG00000040112,MRPS35,mitochondrial ribosomal protein S35,cytoplasm|mitochondrion|mitochondrial small ribosomal subunit|mitochondrial small ribosomal subunit|,"DNA damage response, detection of DNA damage|peptide biosynthetic process|",poly(A) RNA binding|,10,0.6,0.36,10,1.1,1.21,0.9,1.24,0.418,-4.8,4.6
ENSMUSG00000096010,HIST4H4,"histone cluster 4, H4",None,None,None,0,0,0,1,-2.6,1.33,-2.6,1.24,0.418,-5,1.5
ENSMUSG00000019143,HARS2,"histidyl-tRNA synthetase 2, mitochondrial",mitochondrial matrix|,translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|gene expression|,histidine-tRNA ligase activity|ATP binding|poly(A) RNA binding|,0,0,0,1,2.2,1.33,2.2,1.24,0.418,-1.6,4
ENSMUSG00000020689,ITGB3,"integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)",nucleus|plasma membrane|plasma membrane|integral component of plasma membrane|focal adhesion|integrin complex|cell surface|platelet alpha granule membrane|lamellipodium membrane|melanosome|receptor complex|extracellular vesicular exosome|alphav-beta3 integrin-vitronectin complex|,positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|platelet degranulation|protein folding|cell-substrate junction assembly|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|axon guidance|blood coagulation|positive regulation of endothelial cell migration|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|smooth muscle cell migration|viral process|platelet activation|platelet activation|extracellular matrix organization|positive regulation of vascular endothelial growth factor receptor signaling pathway|cell-substrate adhesion|activation of protein kinase activity|negative regulation of lipid transport|tube development|wound healing|regulation of bone resorption|negative regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of lipoprotein metabolic process|leukocyte migration|angiogenesis involved in wound healing|platelet aggregation|,protein disulfide isomerase activity|receptor activity|platelet-derived growth factor receptor binding|protein binding|identical protein binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor 2 binding|cell adhesion molecule binding|,10,-0.8,0.816,10,-0.9,0.537,-0.8,1.24,0.418,-4.8,2.5
ENSMUSG00000096141,DNAH7A,"dynein, axonemal, heavy chain 7A",cilium|,biological_process|,nucleotide binding|molecular_function|ATP binding|,0,0,0,1,2.2,1.33,2.2,1.24,0.418,-1.6,4
ENSMUSG00000019857,ASF1A,anti-silencing function 1A histone chaperone,nuclear chromatin|nucleus|nucleus|nucleoplasm|protein complex|,"osteoblast differentiation|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|transcription, DNA-templated|chromatin modification|negative regulation of chromatin silencing|muscle cell differentiation|",chromatin binding|protein binding|histone binding|,10,0.8,0.13,9,-1.5,1.64,-1.4,1.24,0.418,-4.4,3.9
ENSMUSG00000002731,PRKRA,"protein kinase, interferon-inducible double stranded RNA dependent activator",cytoplasm|cytosol|membrane|perinuclear region of cytoplasm|,protein phosphorylation|immune response|negative regulation of cell proliferation|response to virus|gene expression|production of siRNA involved in RNA interference|cellular response to oxidative stress|outer ear morphogenesis|middle ear morphogenesis|positive regulation of catalytic activity|skeletal system morphogenesis|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|enzyme activator activity|protein homodimerization activity|poly(A) RNA binding|,8,-0.5,0.0808,10,5.7,2.72,-1.1,1.24,0.418,-4,10.9
ENSMUSG00000003721,INSIG2,insulin induced gene 2,endoplasmic reticulum membrane|SREBP-SCAP-Insig complex|,triglyceride metabolic process|cholesterol biosynthetic process|negative regulation of steroid biosynthetic process|response to insulin|SREBP signaling pathway|inner ear morphogenesis|middle ear morphogenesis|small molecule metabolic process|negative regulation of fatty acid biosynthetic process|palate development|cranial suture morphogenesis|response to fatty acid|,protein binding|transcription factor binding|,0,0,0,1,2.2,1.33,2.2,1.24,0.418,-1.6,4
ENSMUSG00000053192,MLLT11,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11",intracellular|,"positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of mitochondrial depolarization|positive regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway|",molecular_function|,10,1,0.904,10,-1.5,1.4,-1.6,1.24,0.418,-6.1,5.4
ENSMUSG00000061410,ZCCHC14,"zinc finger, CCHC domain containing 14",None,None,nucleic acid binding|zinc ion binding|phosphatidylinositol binding|,0,0,0,1,-2.6,1.33,-2.6,1.24,0.418,-5,1.5
ENSMUSG00000028893,SESN2,sestrin 2,nucleus|cytoplasm|,regulation of response to reactive oxygen species|,None,10,0.8,0.735,10,0.6,0.611,0.7,1.23,0.42,-2.1,5
ENSMUSG00000067010,VMN2R10,"vomeronasal 2, receptor 10",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,10,1.8,0.947,10,-1,0.813,-1.6,1.23,0.42,-5.8,5.2
ENSMUSG00000053465,HS6ST3,heparan sulfate 6-O-sulfotransferase 3,integral component of membrane|,metabolic process|,sulfotransferase activity|,10,-0.8,0.375,10,-0.8,0.959,-0.8,1.23,0.42,-4,1.9
ENSMUSG00000022802,LMLN,leishmanolysin-like (metallopeptidase M8 family),cytoplasm|lipid particle|focal adhesion|membrane|,proteolysis|mitotic nuclear division|cell adhesion|,metalloendopeptidase activity|metal ion binding|,10,0.7,0.421,10,-2.2,1.38,-2.2,1.23,0.42,-6.5,2.5
ENSMUSG00000043068,FAM89A,"family with sequence similarity 89, member A",None,None,None,1,-2.7,1.16,1,-1.6,0.356,-2.5,1.23,0.42,-5,1.4
ENSMUSG00000042705,COMMD10,COMM domain containing 10,None,None,protein binding|,1,-2.9,1.32,0,0,0,-2.9,1.23,0.42,-6,1.4
ENSMUSG00000051528,OLFR424,olfactory receptor 424,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-2.9,1.32,0,0,0,-2.9,1.23,0.42,-6,1.4
ENSMUSG00000055653,GPC3,glypican 3,proteinaceous extracellular matrix|extracellular space|Golgi lumen|plasma membrane|integral component of plasma membrane|lysosomal lumen|anchored component of plasma membrane|extracellular vesicular exosome|,"retinoid metabolic process|branching involved in ureteric bud morphogenesis|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|phototransduction, visible light|anatomical structure morphogenesis|anterior/posterior axis specification|body morphogenesis|negative regulation of peptidase activity|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|bone mineralization|osteoclast differentiation|lung development|positive regulation of BMP signaling pathway|embryonic hindlimb morphogenesis|small molecule metabolic process|positive regulation of protein catabolic process|positive regulation of endocytosis|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|negative regulation of growth|positive regulation of glucose import|negative regulation of epithelial cell proliferation|coronary vasculature development|mesenchymal cell proliferation involved in ureteric bud development|mesonephric duct morphogenesis|cell proliferation involved in metanephros development|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway|",protein binding|heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity|,10,0.1,0.0105,10,-2.1,3.25,-1.4,1.23,0.42,-6,2.4
ENSMUSG00000034610,ZCCHC11,"zinc finger, CCHC domain containing 11",extracellular space|nucleolus|cytoplasm|extracellular vesicular exosome|,cytokine production|miRNA metabolic process|miRNA catabolic process|stem cell maintenance|pre-miRNA processing|RNA 3'-end processing|regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-6 production|interleukin-6-mediated signaling pathway|,protein binding|zinc ion binding|poly(A) RNA binding|RNA uridylyltransferase activity|,1,-2.9,1.31,0,0,0,-2.9,1.22,0.422,-6,1.4
ENSMUSG00000022594,LYNX1,Ly6/neurotoxin 1,plasma membrane|dendrite|anchored component of membrane|extracellular vesicular exosome|,None,None,10,0.6,0.571,10,-1.5,3.05,-1.3,1.22,0.422,-4.9,2.4
ENSMUSG00000030230,PLCZ1,"phospholipase C, zeta 1",nucleus|cytosol|perinuclear region of cytoplasm|,calcium ion transport|multicellular organismal development|egg activation|lipid catabolic process|intracellular signal transduction|inositol phosphate metabolic process|small molecule metabolic process|,phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|,10,0,0,10,1.8,1.76,1.4,1.22,0.422,-3,6.1
ENSMUSG00000020622,NT5C1B,"5'-nucleotidase, cytosolic IB",nucleus|cytosol|,purine nucleobase metabolic process|purine nucleotide catabolic process|dephosphorylation|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,nucleotide binding|magnesium ion binding|5'-nucleotidase activity|,10,-1.6,2.17,10,0,0,-1.2,1.22,0.422,-3.5,10.8
ENSMUSG00000029176,ANAPC4,anaphase promoting complex subunit 4,nucleus|nucleoplasm|anaphase-promoting complex|cytosol|,G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle|ubiquitin-dependent protein catabolic process|mitotic nuclear division|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|protein phosphatase binding|,7,0.2,0.0994,9,2.6,2.9,1.6,1.22,0.422,-3.8,7.3
ENSMUSG00000059409,PPP2R5D,"protein phosphatase 2, regulatory subunit B', delta",protein phosphatase type 2A complex|nucleus|nucleoplasm|cytosol|,toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|carbohydrate metabolic process|glucose metabolic process|glycolytic process|energy reserve metabolic process|nervous system development|dephosphorylation|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|regulation of catalytic activity|regulation of catalytic activity|stress-activated MAPK cascade|,protein serine/threonine phosphatase activity|protein binding|protein phosphatase type 2A regulator activity|,10,-2.6,1.06,10,-0.8,0.715,-1,1.22,0.422,-8,2
ENSMUSG00000058444,MAP2K5,mitogen-activated protein kinase kinase 5,nucleus|spindle|cytosol|,negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|signal transduction|heart development|peptidyl-tyrosine phosphorylation|positive regulation of cell growth|negative regulation of NF-kappaB transcription factor activity|negative regulation of heterotypic cell-cell adhesion|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of interleukin-8 biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of protein metabolic process|negative regulation of response to cytokine stimulus|ERK5 cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|metal ion binding|,10,-6.1,3.64,10,-1,0.627,-0.7,1.21,0.425,-11.2,3.2
ENSMUSG00000031132,CD40LG,CD40 ligand,extracellular space|plasma membrane|integral component of plasma membrane|external side of plasma membrane|integral component of membrane|,inflammatory response|leukocyte cell-cell adhesion|platelet activation|B cell differentiation|positive regulation of interleukin-12 production|B cell proliferation|negative regulation of apoptotic process|isotype switching|immunoglobulin secretion|regulation of immune response|regulation of immunoglobulin secretion|positive regulation of endothelial cell apoptotic process|,cytokine activity|tumor necrosis factor receptor binding|CD40 receptor binding|,10,-2.2,0.622,9,1.4,1.24,1.1,1.21,0.425,-7.5,4.2
ENSMUSG00000016757,TTLL12,"tubulin tyrosine ligase-like family, member 12",None,cellular protein modification process|,None,10,0,0,10,1.8,2.51,1.2,1.21,0.425,-7,5
ENSMUSG00000026468,LHX4,LIM homeobox 4,nucleus|,"placenta development|transcription, DNA-templated|regulation of transcription, DNA-templated|motor neuron axon guidance|organ morphogenesis|medial motor column neuron differentiation|negative regulation of apoptotic process|",sequence-specific DNA binding transcription factor activity|zinc ion binding|sequence-specific DNA binding|,1,-2.9,1.28,0,0,0,-2.9,1.2,0.427,-6,1.4
ENSMUSG00000032589,BSN,bassoon presynaptic cytomatrix protein,nucleus|cytoplasm|cytoskeleton|cell junction|dendrite|neuron projection terminus|presynaptic active zone|,synaptic transmission|,metal ion binding|,0,0,0,1,2.2,1.29,2.2,1.2,0.427,-1.6,4
ENSMUSG00000040771,OARD1,O-acyl-ADP-ribose deacylase 1,None,purine nucleoside metabolic process|,purine nucleoside binding|protein binding|deacetylase activity|,1,-2.9,1.28,0,0,0,-2.9,1.2,0.427,-6,1.4
ENSMUSG00000037725,CKAP2,cytoskeleton associated protein 2,spindle pole|centrosome|cytoplasmic microtubule|,mitotic cytokinesis|apoptotic process|negative regulation of microtubule depolymerization|positive regulation of transcription from RNA polymerase II promoter|,None,10,1.5,1.78,10,-2.1,2.33,-1,1.2,0.427,-6.5,4.3
ENSMUSG00000057723,KRT33B,keratin 33B,extracellular space|intermediate filament|,aging|hair cycle|,structural molecule activity|,0,0,0,1,2.2,1.29,2.2,1.2,0.427,-1.6,4
ENSMUSG00000003873,BAX,BCL2-associated X protein,nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|cytosol|membrane|pore complex|extracellular vesicular exosome|Bcl-2 family protein complex|BAX complex|,response to acid|ovarian follicle development|neuron migration|T cell homeostatic proliferation|B cell homeostasis|B cell apoptotic process|kidney development|release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|B cell homeostatic proliferation|positive regulation of B cell apoptotic process|glycosphingolipid metabolic process|regulation of nitrogen utilization|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|transformed cell apoptotic process|germ cell development|mitochondrial fusion|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|apoptotic mitochondrial changes|fertilization|response to toxic substance|response to salt stress|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|viral process|hypothalamus development|cerebral cortex development|nuclear fragmentation involved in apoptotic nuclear change|negative regulation of protein binding|positive regulation of protein oligomerization|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|release of matrix enzymes from mitochondria|negative regulation of peptidyl-serine phosphorylation|regulation of mammary gland epithelial cell proliferation|cellular response to UV|ectopic germ cell programmed cell death|odontogenesis of dentin-containing tooth|positive regulation of apoptotic process|regulation of protein homodimerization activity|regulation of protein heterodimerization activity|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|mitochondrial fragmentation involved in apoptotic process|development of secondary sexual characteristics|retinal cell programmed cell death|positive regulation of developmental pigmentation|negative regulation of fibroblast proliferation|spermatid differentiation|post-embryonic camera-type eye morphogenesis|response to axon injury|homeostasis of number of cells within a tissue|protein oligomerization|protein homooligomerization|positive regulation of release of sequestered calcium ion into cytosol|neuron apoptotic process|regulation of cell cycle|regulation of mitochondrial membrane potential|Sertoli cell proliferation|retina development in camera-type eye|positive regulation of apoptotic process involved in mammary gland involution|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|thymocyte apoptotic process|cellular response to organic substance|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in patterning of blood vessels|apoptotic process involved in embryonic digit morphogenesis|positive regulation of apoptotic DNA fragmentation|retinal cell apoptotic process|B cell receptor apoptotic signaling pathway|negative regulation of apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|lipid binding|channel activity|identical protein binding|protein homodimerization activity|protein homodimerization activity|protein heterodimerization activity|BH3 domain binding|BH3 domain binding|,10,-1.1,0.377,10,-0.9,0.946,-0.9,1.2,0.427,-6.8,2.6
ENSMUSG00000079614,SEH1L,SEH1-like (S. cerevisiae),kinetochore|condensed chromosome kinetochore|nuclear envelope|cytosol|nuclear pore outer ring|nuclear pore outer ring|,mitotic cell cycle|carbohydrate metabolic process|nuclear pore organization|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|hexose transport|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|mRNA transport|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|transmembrane transport|,None,0,0,0,1,2.2,1.29,2.2,1.2,0.427,-1.6,4
ENSMUSG00000033788,DYSF,dysferlin,plasma membrane|integral component of membrane|lamellipodium|T-tubule|cytoplasmic vesicle membrane|sarcolemma|extracellular vesicular exosome|,plasma membrane repair|vesicle fusion|,calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|,0,0,0,1,-2.6,1.29,-2.6,1.2,0.427,-5,1.5
ENSMUSG00000039852,RERE,arginine-glutamic acid dipeptide (RE) repeats,histone deacetylase complex|nucleus|,"chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|NLS-bearing protein import into nucleus|multicellular organismal development|",chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|poly-glutamine tract binding|zinc ion binding|sequence-specific DNA binding|,0,0,0,1,2.2,1.29,2.2,1.2,0.427,-1.6,4
ENSMUSG00000057469,E2F6,E2F transcription factor 6,nucleus|transcription factor complex|MLL1 complex|,"regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|,0,0,0,1,-2.6,1.29,-2.6,1.2,0.427,-5,1.5
ENSMUSG00000042499,HOXD11,homeobox D11,nucleus|,"metanephros development|branching involved in ureteric bud morphogenesis|organ induction|transcription, DNA-templated|regulation of transcription, DNA-templated|anterior/posterior pattern specification|dorsal/ventral pattern formation|proximal/distal pattern formation|positive regulation of cell development|positive regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|embryonic digit morphogenesis|developmental growth|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,-4.6,1.11,10,-1.2,0.955,-0.7,1.2,0.427,-8.1,3.2
ENSMUSG00000057388,MRPL18,mitochondrial ribosomal protein L18,extracellular space|mitochondrion|mitochondrial ribosome|,translation|rRNA import into mitochondrion|,structural constituent of ribosome|5S rRNA binding|,0,0,0,1,2.2,1.29,2.2,1.2,0.427,-1.6,4
ENSMUSG00000022309,ANGPT1,angiopoietin 1,extracellular region|extracellular space|plasma membrane|microvillus|membrane raft|extracellular vesicular exosome|,in utero embryonic development|sprouting angiogenesis|positive regulation of receptor internalization|negative regulation of cell adhesion|activation of transmembrane receptor protein tyrosine kinase activity|blood coagulation|positive regulation of endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of satellite cell proliferation|hemopoiesis|cell differentiation|heparin biosynthetic process|positive regulation of protein ubiquitination|cell-substrate adhesion|positive regulation of peptidyl-serine phosphorylation|protein localization to cell surface|negative regulation of apoptotic process|negative regulation of vascular permeability|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|Tie signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive chemotaxis|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|glomerulus vasculature development|negative regulation of endothelial cell apoptotic process|,receptor tyrosine kinase binding|,10,1.2,0.686,10,1.6,0.656,1.3,1.19,0.429,-4.3,5.1
ENSMUSG00000042351,GRAP2,GRB2-related adaptor protein 2,nucleus|cytoplasm|endosome|cytosol|,Ras protein signal transduction|cell-cell signaling|positive regulation of signal transduction|T cell costimulation|Fc-epsilon receptor signaling pathway|innate immune response|T cell receptor signaling pathway|,SH3/SH2 adaptor activity|protein binding|,10,-3.3,0.719,10,-0.7,0.829,-0.9,1.19,0.429,-6.6,2.9
ENSMUSG00000022799,ARHGAP31,Rho GTPase activating protein 31,cytosol|focal adhesion|lamellipodium|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|SH3 domain binding|,1,-2.2,0.824,1,-1.8,0.507,-2,1.19,0.429,-4,1.5
ENSMUSG00000003469,PHYHIP,phytanoyl-CoA 2-hydroxylase interacting protein,None,None,None,0,0,0,1,-2.6,1.28,-2.6,1.19,0.429,-5,1.5
ENSMUSG00000018604,TBX3,T-box 3,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|skeletal system development|blood vessel development|in utero embryonic development|heart looping|outflow tract morphogenesis|atrioventricular bundle cell differentiation|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell aging|positive regulation of cell proliferation|anterior/posterior axis specification, embryo|organ morphogenesis|specification of organ position|stem cell maintenance|limbic system development|male genitalia development|female genitalia development|negative regulation of epithelial cell differentiation|mammary gland development|luteinizing hormone secretion|embryonic forelimb morphogenesis|forelimb morphogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|negative regulation of myoblast differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|follicle-stimulating hormone secretion|mesoderm morphogenesis|palate development|ventricular septum morphogenesis|branching involved in mammary gland duct morphogenesis|mammary placode formation|cardiac muscle cell fate commitment|sinoatrial node cell development|cellular senescence|positive regulation of stem cell proliferation|",RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,10,3.8,1.39,10,1.7,0.649,2.1,1.19,0.429,-4.8,7.7
ENSMUSG00000075415,FNBP1,formin binding protein 1,lysosome|cytoskeleton|plasma membrane|coated pit|cell cortex|cytoplasmic membrane-bounded vesicle|,endocytosis|,protein binding|lipid binding|identical protein binding|,9,-1.1,1.13,9,-0.5,0.392,-0.8,1.19,0.429,-12.4,2.9
ENSMUSG00000050379,6-Sep,septin 6,condensed chromosome kinetochore|spindle|synaptic vesicle|midbody|septin complex|cleavage furrow|axon terminus|,cytokinesis|viral process|,protein binding|GTP binding|,8,1.7,2.09,10,-0.2,0.0658,1.5,1.18,0.432,-12.1,3.7
ENSMUSG00000028821,SYF2,SYF2 pre-mRNA-splicing factor,nucleus|nucleus|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|in utero embryonic development|gastrulation|embryonic organ development|",poly(A) RNA binding|,9,-5,1.18,10,-1.6,1.76,-1.6,1.18,0.432,-9.6,2.5
ENSMUSG00000034456,UROC1,urocanate hydratase 1,cytosol|cytosol|,histidine catabolic process|histidine catabolic process|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|cellular nitrogen compound metabolic process|small molecule metabolic process|,urocanate hydratase activity|urocanate hydratase activity|,10,-0.5,0.379,10,-1.3,1.02,-1.3,1.18,0.432,-8.9,3.2
ENSMUSG00000034252,SENP6,SUMO1/sentrin specific peptidase 6,nucleus|cytoplasm|,proteolysis|protein sumoylation|protein desumoylation|protein modification by small protein removal|regulation of spindle assembly|regulation of kinetochore assembly|,protein binding|SUMO-specific protease activity|,10,-2.1,1.29,10,-0.7,0.671,-0.7,1.18,0.432,-4.8,3
ENSMUSG00000042289,HSD3B7,"hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",cellular_component|endoplasmic reticulum membrane|integral component of membrane|,bile acid biosynthetic process|bile acid metabolic process|small molecule metabolic process|oxidation-reduction process|,"3-beta-hydroxy-delta5-steroid dehydrogenase activity|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity|",0,0,0,1,2.1,1.25,2.1,1.17,0.434,-1.6,4
ENSMUSG00000002289,ANGPTL4,angiopoietin-like 4,extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|blood microparticle|,angiogenesis|response to hypoxia|cell differentiation|negative regulation of apoptotic process|cellular lipid metabolic process|small molecule metabolic process|positive regulation of angiogenesis|negative regulation of lipoprotein lipase activity|protein homooligomerization|triglyceride homeostasis|negative regulation of endothelial cell apoptotic process|,enzyme inhibitor activity|protein binding|,0,0,0,1,2.1,1.25,2.1,1.17,0.434,-1.6,4
ENSMUSG00000032288,IMP3,"IMP3, U3 small nucleolar ribonucleoprotein",nucleus|nucleolus|ribonucleoprotein complex|,rRNA processing|,protein binding|rRNA binding|poly(A) RNA binding|,0,0,0,1,2.1,1.25,2.1,1.17,0.434,-1.6,4
ENSMUSG00000053965,PDE5A,"phosphodiesterase 5A, cGMP-specific",cellular_component|cytosol|,signal transduction|blood coagulation|positive regulation of cardiac muscle hypertrophy|negative regulation of T cell proliferation|positive regulation of MAP kinase activity|cGMP catabolic process|cGMP catabolic process|negative regulation of cardiac muscle contraction|relaxation of cardiac muscle|positive regulation of oocyte development|,"3',5'-cyclic-nucleotide phosphodiesterase activity|cGMP binding|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|",8,-1.2,1.56,9,1.3,0.896,-1,1.16,0.436,-9.8,6.9
ENSMUSG00000037411,SERPINE1,"serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1",extracellular region|extracellular region|extracellular space|plasma membrane|extracellular matrix|platelet alpha granule lumen|,"chronological cell aging|angiogenesis|platelet degranulation|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|blood coagulation|gene expression|regulation of receptor activity|negative regulation of plasminogen activation|negative regulation of plasminogen activation|negative regulation of endopeptidase activity|negative regulation of smooth muscle cell migration|platelet activation|positive regulation of blood coagulation|negative regulation of blood coagulation|extracellular matrix organization|negative regulation of cell migration|positive regulation of interleukin-8 production|negative regulation of cell adhesion mediated by integrin|positive regulation of leukotriene production involved in inflammatory response|regulation of cell proliferation|fibrinolysis|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of receptor-mediated endocytosis|positive regulation of inflammatory response|defense response to Gram-negative bacterium|negative regulation of fibrinolysis|negative regulation of vascular wound healing|negative regulation of wound healing|cellular response to lipopolysaccharide|positive regulation of monocyte chemotaxis|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of endothelial cell apoptotic process|",protease binding|serine-type endopeptidase inhibitor activity|receptor binding|protein binding|,10,3.2,0.6,10,1.1,1.14,1.5,1.16,0.436,-1.9,6.8
ENSMUSG00000026851,BC005624,cDNA sequence BC005624,nucleus|cytoplasm|,biological_process|,molecular_function|,0,0,0,1,-2.5,1.25,-2.5,1.16,0.436,-5,1.5
ENSMUSG00000075304,SP5,Sp5 transcription factor,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|post-anal tail morphogenesis|bone morphogenesis|",sequence-specific DNA binding|metal ion binding|,1,2.1,1.64,1,-1.7,0.421,2,1.16,0.436,-2.5,5
ENSMUSG00000025810,NRP1,neuropilin 1,semaphorin receptor complex|extracellular space|early endosome|cytosol|neurofilament|plasma membrane|plasma membrane|cell surface|integral component of membrane|axon|growth cone|cytoplasmic vesicle|neuronal cell body|receptor complex|sorting endosome|,angiogenesis|angiogenesis|patterning of blood vessels|neuron migration|positive regulation of endothelial cell proliferation|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|cell adhesion|signal transduction|cell-cell signaling|axon guidance|axon guidance|axonal fasciculation|response to wounding|organ morphogenesis|positive regulation of endothelial cell migration|positive regulation of smooth muscle cell migration|dendrite development|trigeminal nerve morphogenesis|nerve development|retinal ganglion cell axon guidance|cellular response to hepatocyte growth factor stimulus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|VEGF-activated neuropilin signaling pathway|negative regulation of neuron apoptotic process|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|artery morphogenesis|axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of cytokine activity|axonogenesis involved in innervation|regulation of vesicle-mediated transport|dichotomous subdivision of terminal units involved in salivary gland branching|angiogenesis involved in coronary vascular morphogenesis|retina vasculature morphogenesis in camera-type eye|sympathetic ganglion development|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|commissural neuron axon guidance|regulation of retinal ganglion cell axon guidance|endothelial tip cell fate specification|sympathetic neuron projection extension|sympathetic neuron projection guidance|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|positive regulation of retinal ganglion cell axon guidance|protein localization to early endosome|negative regulation of extrinsic apoptotic signaling pathway|,vascular endothelial growth factor-activated receptor activity|vascular endothelial growth factor-activated receptor activity|protein binding|heparin binding|coreceptor activity|semaphorin receptor activity|growth factor binding|growth factor binding|cytokine binding|vascular endothelial growth factor binding|metal ion binding|,10,1.5,1.32,10,-0.7,0.322,-1,1.16,0.436,-5.1,4.8
ENSMUSG00000032116,STT3A,"STT3A, subunit of the oligosaccharyltransferase complex (catalytic)",endoplasmic reticulum membrane|oligosaccharyltransferase complex|oligosaccharyltransferase complex|membrane|integral component of membrane|,protein N-linked glycosylation via asparagine|protein N-linked glycosylation via asparagine|protein N-linked glycosylation via asparagine|co-translational protein modification|post-translational protein modification|cellular protein metabolic process|,dolichyl-diphosphooligosaccharide-protein glycotransferase activity|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|,10,-0.8,0.551,10,-1.1,0.755,-0.8,1.16,0.436,-7.9,4.7
ENSMUSG00000074966,OLFR1275,olfactory receptor 1275,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,1.9,1.24,0,0,0,1.9,1.16,0.436,-1.5,5
ENSMUSG00000062859,TCP11,"t-complex 11, testis-specific",integral component of membrane|,multicellular organismal development|spermatogenesis|cell differentiation|,None,10,-1.6,2.8,10,0.2,0.0313,-1.3,1.16,0.436,-4.1,1.3
ENSMUSG00000002233,RHOC,ras homolog family member C,nucleus|cytosol|plasma membrane|cleavage furrow|extracellular vesicular exosome|,cytokinesis|small GTPase mediated signal transduction|axon guidance|positive regulation of I-kappaB kinase/NF-kappaB signaling|apical junction assembly|regulation of small GTPase mediated signal transduction|,signal transducer activity|protein binding|GTP binding|,9,6,2.98,10,1.4,1.23,1.3,1.16,0.436,-3.6,12.2
ENSMUSG00000022656,PVRL3,poliovirus receptor-related 3,plasma membrane|plasma membrane|cell-cell adherens junction|integral component of membrane|apical junction complex|postsynaptic membrane|,lens morphogenesis in camera-type eye|homophilic cell adhesion|fertilization|single organismal cell-cell adhesion|cell junction assembly|adherens junction organization|cell-cell junction organization|retina morphogenesis in camera-type eye|,protein binding|protein homodimerization activity|cell adhesion molecule binding|,0,0,0,2,2,1.25,2,1.16,0.436,-1.5,4
ENSMUSG00000033060,LMO7,LIM domain 7,ubiquitin ligase complex|nucleus|cytoplasm|,protein ubiquitination|,ubiquitin-protein transferase activity|zinc ion binding|,10,-0.6,0.283,9,-1.1,1.05,-1,1.15,0.439,-6.5,4.1
ENSMUSG00000068101,CENPM,centromere protein M,condensed chromosome kinetochore|nucleus|cytosol|,mitotic cell cycle|,None,3,-2,0.787,5,-1.4,0.536,-1.7,1.15,0.439,-5,3.6
ENSMUSG00000000093,TBX2,T-box 2,nucleus|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|transcription, DNA-templated|muscle cell fate determination|cell aging|positive regulation of cell proliferation|aorta morphogenesis|atrioventricular canal development|embryonic digit morphogenesis|negative regulation of transcription, DNA-templated|embryonic camera-type eye morphogenesis|cardiac muscle tissue development|palate development|positive regulation of cardiac muscle cell proliferation|pharynx development|developmental growth involved in morphogenesis|mammary placode formation|cellular senescence|negative regulation of heart looping|negative regulation of cardiac chamber formation|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,10,-4.1,1.74,10,-0.2,0.0188,-1.4,1.15,0.439,-7.8,1.9
ENSMUSG00000060803,GSTP1,glutathione S-transferase pi 1,extracellular space|intracellular|nucleus|cytoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|extracellular vesicular exosome|TRAF2-GSTP1 complex|,response to reactive oxygen species|negative regulation of acute inflammatory response|negative regulation of protein kinase activity|glutathione metabolic process|xenobiotic metabolic process|xenobiotic metabolic process|central nervous system development|negative regulation of biosynthetic process|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of interleukin-1 beta production|negative regulation of tumor necrosis factor production|regulation of stress-activated MAPK cascade|negative regulation of stress-activated MAPK cascade|positive regulation of superoxide anion generation|common myeloid progenitor cell proliferation|nitric oxide storage|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of JUN kinase activity|small molecule metabolic process|negative regulation of fibroblast proliferation|negative regulation of nitric-oxide synthase biosynthetic process|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|negative regulation of leukocyte proliferation|cellular response to lipopolysaccharide|negative regulation of monocyte chemotactic protein-1 production|glutathione derivative biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway|,glutathione transferase activity|protein binding|JUN kinase binding|kinase regulator activity|S-nitrosoglutathione binding|dinitrosyl-iron complex binding|nitric oxide binding|,10,-0.7,0.738,10,1.2,1,0.9,1.15,0.439,-8.9,4.7
ENSMUSG00000029075,TNFRSF4,"tumor necrosis factor receptor superfamily, member 4",integral component of plasma membrane|external side of plasma membrane|cell surface|,"inflammatory response|immune response|cellular defense response|positive regulation of B cell proliferation|tumor necrosis factor-mediated signaling pathway|T cell proliferation|regulation of apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein kinase activity|negative regulation of transcription, DNA-templated|negative regulation of cytokine secretion|positive regulation of immunoglobulin secretion|",tumor necrosis factor-activated receptor activity|,10,-2.1,2.05,10,-0.3,0.147,-1.9,1.14,0.441,-5,7.4
ENSMUSG00000029726,MEPCE,methylphosphate capping enzyme,None,negative regulation of transcription from RNA polymerase II promoter|RNA methylation|snRNA metabolic process|negative regulation of chromatin binding|snRNA modification|positive regulation of G1/S transition of mitotic cell cycle|,RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|poly(A) RNA binding|,8,3.1,0.777,7,-0.8,0.712,-1.2,1.14,0.441,-4.9,6.5
ENSMUSG00000025856,PDGFA,platelet-derived growth factor alpha polypeptide,Golgi membrane|extracellular region|extracellular space|endoplasmic reticulum lumen|microvillus|cell surface|platelet alpha granule lumen|,angiogenesis|response to hypoxia|cell activation|hair follicle development|positive regulation of mesenchymal cell proliferation|platelet degranulation|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|cell-cell signaling|blood coagulation|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|response to wounding|embryo development|organ morphogenesis|response to inorganic substance|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of smooth muscle cell migration|cell projection assembly|actin cytoskeleton organization|platelet activation|extracellular matrix organization|positive regulation of cell migration|positive regulation of protein autophosphorylation|response to estradiol|response to retinoic acid|regulation of actin cytoskeleton organization|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|Fc-epsilon receptor signaling pathway|wound healing|response to drug|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|skin development|innate immune response|positive regulation of DNA replication|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|lung alveolus development|inner ear development|regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|positive regulation of ERK1 and ERK2 cascade|,platelet-derived growth factor receptor binding|platelet-derived growth factor receptor binding|platelet-derived growth factor receptor binding|protein binding|collagen binding|growth factor activity|protein homodimerization activity|protein heterodimerization activity|platelet-derived growth factor binding|,10,-1,0.667,10,-1,0.568,-1,1.14,0.441,-3.9,4.5
ENSMUSG00000017344,VTN,vitronectin,extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular matrix|extracellular matrix|extracellular matrix|extracellular vesicular exosome|alphav-beta3 integrin-vitronectin complex|blood microparticle|,receptor-mediated endocytosis|immune response|cell adhesion|cell-matrix adhesion|positive regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|positive regulation of smooth muscle cell migration|negative regulation of blood coagulation|extracellular matrix organization|regulation of complement activation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein binding|cell adhesion mediated by integrin|innate immune response|positive regulation of receptor-mediated endocytosis|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell-matrix adhesion|positive regulation of wound healing|,scavenger receptor activity|integrin binding|protein binding|heparin binding|polysaccharide binding|extracellular matrix binding|,10,-5.1,1.49,10,-0.3,0.205,-5,1.14,0.441,-10,2.5
ENSMUSG00000059371,OLFR427,olfactory receptor 427,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-2.8,1.22,0,0,0,-2.8,1.14,0.441,-6,1.4
ENSMUSG00000031397,TKTL1,transketolase-like 1,nucleus|cytoplasm|,glucose catabolic process|thiamine metabolic process|,transketolase activity|metal ion binding|,10,2.1,1.39,10,0.6,0.791,0.7,1.14,0.441,-1.5,6
ENSMUSG00000021733,SLC4A7,"solute carrier family 4, sodium bicarbonate cotransporter, member 7",plasma membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|stereocilium|,ion transport|bicarbonate transport|bicarbonate transport|cochlear nucleus development|sodium ion transmembrane transport|retinal cell programmed cell death|transmembrane transport|auditory receptor cell development|retina vasculature morphogenesis in camera-type eye|,inorganic anion exchanger activity|sodium:bicarbonate symporter activity|,0,0,0,1,2.1,1.22,2.1,1.13,0.443,-1.6,4
ENSMUSG00000021365,NEDD9,"neural precursor cell expressed, developmentally down-regulated 9",spindle pole|nucleus|cytoplasm|Golgi apparatus|spindle|focal adhesion|cell cortex|lamellipodium|,cytoskeleton organization|mitotic nuclear division|cell adhesion|signal transduction|integrin-mediated signaling pathway|regulation of growth|actin filament bundle assembly|,protein binding|,10,-1.6,2.21,10,0.1,0.000473,-1,1.12,0.446,-5.2,2.7
ENSMUSG00000033732,SF3B3,"splicing factor 3b, subunit 3, 130kDa",nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|small nuclear ribonucleoprotein complex|catalytic step 2 spliceosome|,"RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA processing|protein complex assembly|RNA splicing|gene expression|",nucleic acid binding|,1,-2.8,1.21,0,0,0,-2.8,1.12,0.446,-6,1.4
ENSMUSG00000073077,GM7173,predicted gene 7173,cellular_component|,biological_process|,molecular_function|,10,1.5,0.861,10,-0.7,0.556,1.2,1.12,0.446,-8.4,5.7
ENSMUSG00000008601,RAB25,"RAB25, member RAS oncogene family",cytoplasmic membrane-bounded vesicle|pseudopodium|pseudopodium membrane|cytoplasmic vesicle|extracellular vesicular exosome|,small GTPase mediated signal transduction|positive regulation of cell proliferation|protein transport|pseudopodium organization|,protein binding|GTP binding|,10,-0.7,0.262,10,-1.2,1.03,-1.2,1.12,0.446,-5.7,1.7
ENSMUSG00000049612,OMG,oligodendrocyte myelin glycoprotein,plasma membrane|anchored component of membrane|,cell adhesion|neuron projection regeneration|neurotrophin TRK receptor signaling pathway|regulation of collateral sprouting of intact axon in response to injury|regulation of axonogenesis|negative regulation of axonogenesis|,identical protein binding|,10,7.6,4.55,10,-0.5,0.165,7.6,1.12,0.446,-2.4,16
ENSMUSG00000037646,VPS13B,vacuolar protein sorting 13 homolog B (yeast),None,protein transport|,None,10,0,0,10,-2.3,2.19,-2,1.12,0.446,-6.8,2
ENSMUSG00000071470,CCNB1IP1,"cyclin B1 interacting protein 1, E3 ubiquitin protein ligase",synaptonemal complex|,blastocyst formation|reciprocal meiotic recombination|spermatid development|protein ubiquitination|chiasma assembly|,protein binding|zinc ion binding|ligase activity|,8,-6,1.33,10,-0.9,1.01,-0.7,1.11,0.448,-11.4,3.7
ENSMUSG00000005225,PLEKHA8,"pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8",trans-Golgi network|membrane|,lipid transport|protein transport|ER to Golgi ceramide transport|glycolipid transport|,glycolipid transporter activity|glycolipid binding|phosphatidylinositol-4-phosphate binding|ceramide binding|,10,0.7,0.231,10,0.8,0.974,0.8,1.11,0.448,-3.4,4.5
ENSMUSG00000057236,RBBP4,retinoblastoma binding protein 4,nuclear chromatin|nucleus|nucleoplasm|nucleoplasm|Sin3 complex|NuRD complex|NuRD complex|NURF complex|CAF-1 complex|ESC/E(Z) complex|protein complex|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|ATP catabolic process|DNA replication|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell proliferation|chromatin assembly|centromere-specific nucleosome assembly|ATP-dependent chromatin remodeling|regulation of cell cycle|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|protein binding|DNA-dependent ATPase activity|nucleosomal DNA binding|histone binding|histone deacetylase binding|,3,-3.6,2.27,5,-0.7,0.147,-2,1.11,0.448,-7.9,0.8
ENSMUSG00000038126,MPHOSPH9,M-phase phosphoprotein 9,Golgi membrane|cytoplasm|Golgi apparatus|centrosome|centriole|plasma membrane|membrane|,mitotic M phase|,None,10,-0.6,0.23,9,-1,1.02,-0.9,1.11,0.448,-5.7,4.1
ENSMUSG00000037362,NOV,nephroblastoma overexpressed,extracellular region|axon|dendrite|extracellular matrix|neuronal cell body|intracellular membrane-bounded organelle|,regulation of cell growth|regulation of gene expression|,insulin-like growth factor binding|growth factor activity|,9,-0.4,0.0493,10,-1.7,1.57,-0.9,1.11,0.448,-5.2,1.2
ENSMUSG00000022658,TAGLN3,transgelin 3,nucleus|,negative regulation of transcription from RNA polymerase II promoter|central nervous system development|,None,1,-2.8,1.19,0,0,0,-2.8,1.11,0.448,-6,1.4
ENSMUSG00000026839,UPP2,uridine phosphorylase 2,cytosol|cytosol|type III intermediate filament|,pyrimidine nucleobase metabolic process|nucleoside metabolic process|nucleotide catabolic process|pyrimidine nucleoside salvage|UMP salvage|small molecule metabolic process|uridine metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|,uridine phosphorylase activity|,10,2.1,3.54,10,-1,1.15,-1,1.11,0.448,-5.1,5.2
ENSMUSG00000050926,DCAF12L2,DDB1 and CUL4 associated factor 12-like 2,None,None,None,10,-3.4,2.2,10,-0.5,0.287,-1.4,1.11,0.448,-6.8,1.2
ENSMUSG00000090223,PCP4,Purkinje cell protein 4,nucleus|cytosol|,central nervous system development|,calmodulin binding|,6,-4.7,0.829,6,0.9,0.443,1,1.1,0.45,-7.7,4
ENSMUSG00000038500,PRR3,proline rich 3,None,None,poly(A) RNA binding|metal ion binding|,2,2.2,1.58,1,-1.6,0.334,2.1,1.1,0.45,-2.5,5
ENSMUSG00000007880,ARID1A,AT rich interactive domain 1A (SWI-like),nuclear chromatin|nucleus|nucleus|SWI/SNF complex|npBAF complex|nBAF complex|,"negative regulation of transcription from RNA polymerase II promoter|neural tube closure|cardiac chamber development|optic cup formation involved in camera-type eye development|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|forebrain development|nucleosome mobilization|glucocorticoid receptor signaling pathway|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|placenta blood vessel development|",DNA binding|DNA binding|transcription coactivator activity|protein binding|ligand-dependent nuclear receptor binding|nucleosome binding|,10,-1.7,1.39,10,-0.4,0.271,-0.6,1.1,0.45,-5.3,1.4
ENSMUSG00000022765,SNAP29,"synaptosomal-associated protein, 29kDa",cytoplasm|centrosome|plasma membrane|cell junction|SNARE complex|neuron projection|synapse|,autophagic vacuole fusion|exocytosis|vesicle targeting|protein transport|membrane fusion|,SNAP receptor activity|,0,0,0,2,1.4,1.19,1.4,1.1,0.45,-1.6,3
ENSMUSG00000055943,EMC7,ER membrane protein complex subunit 7,cytoplasm|integral component of membrane|integral component of membrane|ER membrane protein complex|,biological_process|,purine nucleotide binding|carbohydrate binding|,1,-2.4,0.959,1,2.4,1.56,2.3,1.1,0.45,-4.4,5
ENSMUSG00000071661,ZBTB3,zinc finger and BTB domain containing 3,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|metal ion binding|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000027048,ABCB11,"ATP-binding cassette, sub-family B (MDR/TAP), member 11",plasma membrane|integral component of plasma membrane|membrane|integral component of membrane|apical part of cell|intercellular canaliculus|extracellular vesicular exosome|,ATP catabolic process|bile acid biosynthetic process|transport|bile acid metabolic process|bile acid and bile salt transport|canalicular bile acid transport|sodium ion transmembrane transport|small molecule metabolic process|transmembrane transport|,"transporter activity|ATP binding|sodium-exporting ATPase activity, phosphorylative mechanism|canalicular bile acid transmembrane transporter activity|bile acid-exporting ATPase activity|ATPase activity, coupled to transmembrane movement of substances|",10,-1,0.633,10,2.6,3.44,1.6,1.09,0.452,-3.4,7.3
ENSMUSG00000030963,UMOD,uromodulin,spindle pole|extracellular space|Golgi apparatus|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|anchored component of membrane|cytoplasmic vesicle|membrane raft|ciliary membrane|extracellular vesicular exosome|primary cilium|,cellular defense response|heterophilic cell-cell adhesion|leukocyte cell-cell adhesion|excretion|negative regulation of cell proliferation|response to organic substance|chemical homeostasis|metanephric ascending thin limb development|metanephric distal convoluted tubule development|metanephric thick ascending limb development|neutrophil migration|regulation of ion homeostasis|,calcium ion binding|IgG binding|,10,-2.1,2.04,10,0.9,0.085,-1.1,1.09,0.452,-7.4,3.6
ENSMUSG00000053218,GM9900,predicted gene 9900,cellular_component|,biological_process|,molecular_function|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000044499,HS3ST5,heparan sulfate (glucosamine) 3-O-sulfotransferase 5,Golgi membrane|integral component of membrane|,"carbohydrate metabolic process|glycosaminoglycan biosynthetic process|protein sulfation|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|glycosaminoglycan metabolic process|small molecule metabolic process|regulation of viral entry into host cell|negative regulation of coagulation|",protein binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|3'-phosphoadenosine 5'-phosphosulfate binding|,10,-2.5,3.02,10,1.5,1.32,-2.3,1.09,0.452,-7.1,3.5
ENSMUSG00000027508,PAG1,phosphoprotein membrane anchor with glycosphingolipid microdomains 1,plasma membrane|plasma membrane|integral component of membrane|membrane raft|,signal transduction|epidermal growth factor receptor signaling pathway|positive regulation of signal transduction|intracellular signal transduction|T cell receptor signaling pathway|regulation of T cell activation|negative regulation of T cell activation|,SH3/SH2 adaptor activity|protein binding|SH2 domain binding|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000021339,MRS2,MRS2 magnesium transporter,mitochondrial inner membrane|integral component of membrane|,magnesium ion transport|,magnesium ion transmembrane transporter activity|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000003206,EBI3,Epstein-Barr virus induced 3,extracellular space|plasma membrane|,humoral immune response|cytokine-mediated signaling pathway|cytokine-mediated signaling pathway|T-helper 1 type immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of alpha-beta T cell proliferation|,cytokine receptor activity|cytokine activity|protein binding|interleukin-27 receptor binding|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000023852,CHD1,chromodomain helicase DNA binding protein 1,nucleus|cytoplasm|,"chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|DNA duplex unwinding|",DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|methylated histone binding|,1,-2.7,1.17,0,0,0,-2.7,1.09,0.452,-5,1.5
ENSMUSG00000039103,NEXN,nexilin (F actin binding protein),cytoskeleton|cell-substrate adherens junction|Z disc|Z disc|,protein phosphorylation|regulation of cell migration|cardiac muscle fiber development|regulation of cytoskeleton organization|,calmodulin-dependent protein kinase activity|structural constituent of muscle|actin filament binding|,0,0,0,1,2.1,1.18,2.1,1.09,0.452,-1.6,4
ENSMUSG00000074358,CCDC61,coiled-coil domain containing 61,centrosome|,None,None,1,-2.7,1.17,0,0,0,-2.7,1.09,0.452,-5,1.5
ENSMUSG00000000142,AXIN2,axin 2,nucleus|cytoplasm|centrosome|cytoplasmic microtubule|plasma membrane|cell cortex|postsynaptic density|cytoplasmic membrane-bounded vesicle|beta-catenin destruction complex|,positive regulation of protein phosphorylation|intramembranous ossification|chondrocyte differentiation involved in endochondral bone morphogenesis|cell proliferation|negative regulation of cell proliferation|dorsal/ventral axis specification|positive regulation of epithelial to mesenchymal transition|positive regulation of cell death|bone mineralization|regulation of mismatch repair|cellular protein localization|negative regulation of catenin import into nucleus|termination of G-protein coupled receptor signaling pathway|odontogenesis|positive regulation of GTPase activity|maintenance of DNA repeat elements|negative regulation of osteoblast differentiation|mRNA stabilization|regulation of chondrocyte development|regulation of centromeric sister chromatid cohesion|cellular response to organic cyclic compound|negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|Wnt signaling pathway involved in somitogenesis|,signal transducer activity|GTPase activator activity|protein binding|beta-catenin binding|beta-catenin binding|enzyme binding|protein kinase binding|ubiquitin protein ligase binding|armadillo repeat domain binding|I-SMAD binding|,10,2.8,3.18,10,0.4,0.0903,2.5,1.08,0.455,-7.9,8.2
ENSMUSG00000078566,BNIP3,BCL2/adenovirus E1B 19kDa interacting protein 3,nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|dendrite|integral component of mitochondrial outer membrane|mitochondrial membrane|mitochondrial membrane|,response to hypoxia|apoptotic process|cell death|granzyme-mediated apoptotic signaling pathway|positive regulation of autophagy|negative regulation of mitochondrial fusion|viral process|mitochondrial protein catabolic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of programmed cell death|positive regulation of protein complex disassembly|mitochondrial fragmentation involved in apoptotic process|negative regulation of membrane potential|regulation of mitochondrial membrane permeability|autophagic cell death|brown fat cell differentiation|neuron apoptotic process|defense response to virus|response to hyperoxia|cellular response to hydrogen peroxide|cellular response to mechanical stimulus|cellular response to cobalt ion|cellular response to hypoxia|reactive oxygen species metabolic process|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|mitochondrial outer membrane permeabilization|intrinsic apoptotic signaling pathway in response to hypoxia|,protein binding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|GTPase binding|,9,-2,1.69,10,-0.1,0.0113,-1.1,1.08,0.455,-6.5,2.5
ENSMUSG00000034040,WBSCR17,Williams-Beuren syndrome chromosome region 17,Golgi membrane|integral component of membrane|,protein glycosylation|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,6,2.98,10,-0.8,0.545,-0.9,1.08,0.455,-5.2,11.9
ENSMUSG00000046991,WDR27,WD repeat domain 27,nucleus|,None,None,1,-2.7,1.16,0,0,0,-2.7,1.08,0.455,-5,1.5
ENSMUSG00000032451,TRIM42,tripartite motif containing 42,intracellular|,None,zinc ion binding|,10,-4.5,1.2,10,1.5,0.477,1.4,1.08,0.455,-7.2,4.7
ENSMUSG00000031666,RBL2,retinoblastoma-like 2,nucleus|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|extracellular vesicular exosome|,"mitotic cell cycle|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|chromatin modification|regulation of lipid kinase activity|regulation of cell cycle|",DNA binding|protein binding|,7,2.6,1.1,9,-5.2,1.78,1.4,1.08,0.455,-11.7,5.3
ENSMUSG00000018862,OTOP3,otopetrin 3,integral component of membrane|,None,metal ion binding|,1,-3,1.45,1,-0.7,0.0861,-2.9,1.08,0.455,-6,1.4
ENSMUSG00000000708,KAT2B,K(lysine) acetyltransferase 2B,PCAF complex|kinetochore|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|A band|I band|actomyosin|,chromatin organization|chromatin remodeling|chromatin remodeling|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|protein acetylation|cell cycle arrest|Notch signaling pathway|negative regulation of cell proliferation|gene expression|regulation of protein ADP-ribosylation|viral process|N-terminal peptidyl-lysine acetylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|cellular response to insulin stimulus|histone H3 acetylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|,transcription cofactor activity|transcription coactivator activity|histone acetyltransferase activity|lysine N-acetyltransferase activity|lysine N-acetyltransferase activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|transcription factor binding|acetyltransferase activity|protein kinase binding|protein complex binding|histone deacetylase binding|,9,0.8,0.0692,9,1.2,1.13,1.1,1.08,0.455,-2.7,6.5
ENSMUSG00000015337,ENDOG,endonuclease G,mitochondrion|,in utero embryonic development|apoptotic DNA fragmentation|DNA recombination|response to tumor necrosis factor|positive regulation of apoptotic process|response to antibiotic|,nucleic acid binding|nuclease activity|endonuclease activity|metal ion binding|,10,1,1.53,10,0,0,0.8,1.08,0.455,-6.5,5
ENSMUSG00000073565,PRR16,proline rich 16,None,None,None,10,1.6,1.78,10,-1.2,1.84,-1.1,1.07,0.457,-4.2,4.2
ENSMUSG00000074748,ATXN7L3B,ataxin 7-like 3B,None,None,None,1,-2.7,1.12,1,-1.4,0.254,-2.5,1.07,0.457,-5,1.4
ENSMUSG00000021708,RASGRF2,Ras protein-specific guanine nucleotide-releasing factor 2,endoplasmic reticulum membrane|cytosol|plasma membrane|,small GTPase mediated signal transduction|synaptic transmission|positive regulation of Rho GTPase activity|positive regulation of apoptotic process|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,Rho guanyl-nucleotide exchange factor activity|calmodulin binding|,10,0,0,9,-1.2,1.76,-0.9,1.07,0.457,-4.5,3.1
ENSMUSG00000024563,SMAD2,SMAD family member 2,nuclear chromatin|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|activin responsive factor complex|SMAD protein complex|SMAD2-SMAD3 protein complex|,"negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|in utero embryonic development|endoderm formation|mesoderm formation|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|zygotic specification of dorsal/ventral axis|gastrulation|negative regulation of cell proliferation|response to glucose|post-embryonic development|anterior/posterior pattern specification|gene expression|positive regulation of epithelial to mesenchymal transition|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in regulation of gene expression|insulin secretion|lung development|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|pancreas development|primary miRNA processing|activin receptor signaling pathway|organ growth|intracellular signal transduction|nodal signaling pathway|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of binding|palate development|pericardium development|response to cholesterol|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|","DNA binding|chromatin binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|transcription factor binding|phosphatase binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding|activating transcription factor binding|type I transforming growth factor beta receptor binding|enhancer binding|SMAD binding|metal ion binding|co-SMAD binding|I-SMAD binding|R-SMAD binding|",10,-0.3,0.0585,10,-5.5,2.01,-0.8,1.07,0.457,-10.3,1.2
ENSMUSG00000027796,SMAD9,SMAD family member 9,intracellular|nucleus|nucleoplasm|transcription factor complex|cytosol|,"ureteric bud development|response to hypoxia|Mullerian duct regression|transcription, DNA-templated|protein phosphorylation|transforming growth factor beta receptor signaling pathway|BMP signaling pathway|midbrain development|hindbrain development|intracellular signal transduction|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|cartilage development|bone development|cellular response to organic cyclic compound|","DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|metal ion binding|",1,0.7,0.213,1,-2.7,1.56,-2.6,1.07,0.457,-5,1.5
ENSMUSG00000040957,CABLES1,Cdk5 and Abl enzyme substrate 1,nucleus|cytosol|,cell cycle|nervous system development|blood coagulation|regulation of protein kinase activity|cell division|regulation of cell division|regulation of cell cycle|,protein binding|cyclin-dependent protein serine/threonine kinase regulator activity|,10,-1.4,1.5,10,-0.3,0.0354,-0.9,1.07,0.457,-5.4,2.8
ENSMUSG00000036814,SLC6A20A,"solute carrier family 6 (neurotransmitter transporter), member 20A",plasma membrane|integral component of plasma membrane|membrane|integral component of membrane|apical plasma membrane|,amino acid transmembrane transport|amino acid transmembrane transport|transport|neurotransmitter transport|amino acid transport|amino acid transport|glycine transport|proline transport|,neurotransmitter:sodium symporter activity|amino acid transmembrane transporter activity|amino acid transmembrane transporter activity|symporter activity|,0,0,0,1,2,1.14,2,1.06,0.459,-1.6,4
ENSMUSG00000019558,SLC6A8,"solute carrier family 6 (neurotransmitter transporter), member 8",cellular_component|plasma membrane|integral component of plasma membrane|integral component of membrane|,creatine metabolic process|transport|sodium ion transport|neurotransmitter transport|muscle contraction|biological_process|choline transport|creatine transport|cellular nitrogen compound metabolic process|small molecule metabolic process|creatine transmembrane transport|creatine transmembrane transport|creatine transmembrane transport|,molecular_function|creatine transmembrane transporter activity|creatine:sodium symporter activity|neurotransmitter:sodium symporter activity|choline transmembrane transporter activity|,0,0,0,1,2,1.14,2,1.06,0.459,-1.6,4
ENSMUSG00000028884,RPA2,"replication protein A2, 32kDa","chromosome, telomeric region|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication factor A complex|PML body|PML body|site of double-strand break|","G1/S transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage removal|telomere maintenance via recombination|telomere maintenance|telomere maintenance|double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|DNA replication|DNA replication|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|double-strand break repair|regulation of double-strand break repair via homologous recombination|mitotic G1 DNA damage checkpoint|telomere maintenance via semi-conservative replication|regulation of DNA damage checkpoint|",damaged DNA binding|single-stranded DNA binding|single-stranded DNA binding|single-stranded DNA binding|protein binding|enzyme binding|protein phosphatase binding|ubiquitin protein ligase binding|protein N-terminus binding|,4,-1.3,1.22,6,1.7,1.23,-1.2,1.06,0.459,-4,3.7
ENSMUSG00000026686,LMX1A,"LIM homeobox transcription factor 1, alpha",nucleus|,"regulation of cell growth|transcription, DNA-templated|regulation of transcription, DNA-templated|axon guidance|dentate gyrus development|cerebellum development|central nervous system neuron differentiation|midbrain development|negative regulation of neuron differentiation|dopaminergic neuron differentiation|",sequence-specific DNA binding transcription factor activity|zinc ion binding|sequence-specific DNA binding|,9,1.9,1.08,10,-1.2,0.742,-1.1,1.06,0.459,-6.1,5
ENSMUSG00000023828,SLC22A3,"solute carrier family 22 (organic cation transporter), member 3",plasma membrane|integral component of plasma membrane|membrane|,drug transmembrane transport|organic cation transport|quaternary ammonium group transport|dopamine transport|regulation of appetite|ion transmembrane transport|small molecule metabolic process|histamine uptake|transmembrane transport|toxin transport|,dopamine transmembrane transporter activity|protein binding|organic cation transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|toxin transporter activity|,0,0,0,1,-2.5,1.14,-2.5,1.06,0.459,-5,1.5
ENSMUSG00000031740,MMP2,"matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)",extracellular region|proteinaceous extracellular matrix|extracellular space|nucleus|mitochondrion|plasma membrane|sarcomere|,angiogenesis|response to hypoxia|blood vessel maturation|intramembranous ossification|proteolysis|embryo implantation|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|cellular protein metabolic process|face morphogenesis|bone trabecula formation|cellular response to amino acid stimulus|,metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|zinc ion binding|,9,-3.5,1.03,9,-1,0.444,-1.4,1.06,0.459,-7,3.6
ENSMUSG00000016529,IL10,interleukin 10,extracellular space|,"response to molecule of bacterial origin|negative regulation of cytokine secretion involved in immune response|negative regulation of chronic inflammatory response to antigenic stimulus|positive regulation of B cell apoptotic process|inflammatory response|cytoplasmic sequestering of NF-kappaB|cell-cell signaling|regulation of gene expression|response to activity|response to inactivity|hemopoiesis|B cell differentiation|leukocyte chemotaxis|negative regulation of myeloid dendritic cell activation|negative regulation of B cell proliferation|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|receptor biosynthetic process|response to insulin|response to carbon monoxide|type 2 immune response|B cell proliferation|negative regulation of T cell proliferation|response to drug|negative regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|negative regulation of apoptotic process|negative regulation of growth of symbiont in host|negative regulation of nitric oxide biosynthetic process|regulation of isotype switching|negative regulation of MHC class II biosynthetic process|positive regulation of MHC class II biosynthetic process|negative regulation of interferon-alpha biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cytokine secretion|negative regulation of membrane protein ectodomain proteolysis|positive regulation of sequence-specific DNA binding transcription factor activity|response to glucocorticoid|regulation of sensory perception of pain|branching involved in labyrinthine layer morphogenesis|cellular response to lipopolysaccharide|cellular response to estradiol stimulus|",cytokine activity|interleukin-10 receptor binding|growth factor activity|,10,1.9,1.99,10,-0.8,0.44,1.9,1.06,0.459,-2.5,5.9
ENSMUSG00000027399,IL1A,"interleukin 1, alpha",extracellular region|extracellular space|extracellular space|cytosol|,fever generation|apoptotic process|inflammatory response|immune response|cell proliferation|negative regulation of cell proliferation|positive regulation vascular endothelial growth factor production|cytokine-mediated signaling pathway|cellular response to heat|ectopic germ cell programmed cell death|positive regulation of interleukin-2 biosynthetic process|positive regulation of angiogenesis|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|response to copper ion|positive regulation of cytokine secretion|positive regulation of cell division|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,cytokine activity|interleukin-1 receptor binding|copper ion binding|protein binding|,10,-1.9,1.45,10,-0.7,0.151,-1.7,1.06,0.459,-7.6,4.1
ENSMUSG00000005687,BCAS2,breast carcinoma amplified sequence 2,nucleus|spliceosomal complex|nucleolus|cell junction|,"RNA splicing, via transesterification reactions|mRNA processing|RNA splicing|",protein binding|,10,-0.5,0.273,10,-3.8,1.33,-0.7,1.06,0.459,-8.2,1.5
ENSMUSG00000039164,NAIF1,nuclear apoptosis inducing factor 1,nucleus|mitochondrion|plasma membrane|,negative regulation of cell growth|regulation of mitochondrial membrane permeability involved in apoptotic process|,molecular_function|,1,1.8,1.14,0,0,0,1.8,1.06,0.459,-1.6,4
ENSMUSG00000052914,CYP2J6,"cytochrome P450, family 2, subfamily j, polypeptide 6",endoplasmic reticulum|membrane|intracellular membrane-bounded organelle|,retinoid metabolic process|arachidonic acid metabolic process|epoxygenase P450 pathway|linoleic acid metabolic process|oxidation-reduction process|,"NADPH-hemoprotein reductase activity|monooxygenase activity|iron ion binding|arachidonic acid epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|arachidonic acid 11,12-epoxygenase activity|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|metal ion binding|aromatase activity|linoleic acid epoxygenase activity|",9,-1.1,0.79,9,-0.7,0.429,-1,1.06,0.459,-4.1,2.2
ENSMUSG00000042626,SHC1,SHC (Src homology 2 domain containing) transforming protein 1,mitochondrial matrix|cytosol|plasma membrane|plasma membrane|Shc-EGFR complex|,MAPK cascade|activation of MAPK activity|angiogenesis|activation of signaling protein activity involved in unfolded protein response|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|Ras protein signal transduction|heart development|blood coagulation|positive regulation of cell proliferation|insulin receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|single organismal cell-cell adhesion|peptidyl-tyrosine phosphorylation|platelet activation|endoplasmic reticulum unfolded protein response|actin cytoskeleton reorganization|Fc-epsilon receptor signaling pathway|regulation of growth|cellular protein metabolic process|innate immune response|positive regulation of DNA replication|neurotrophin TRK receptor signaling pathway|leukocyte migration|,protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity|epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|phospholipid binding|ephrin receptor binding|,0,0,0,1,-2.5,1.14,-2.5,1.06,0.459,-5,1.5
ENSMUSG00000005069,PEX5,peroxisomal biogenesis factor 5,intracellular|cytoplasm|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|Golgi apparatus|cytosol|membrane|protein complex|,"very long-chain fatty acid metabolic process|neuron migration|protein targeting to peroxisome|protein targeting to peroxisome|fatty acid beta-oxidation|mitochondrial membrane organization|endoplasmic reticulum organization|protein import into peroxisome matrix|protein import into peroxisome matrix|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein import into peroxisome matrix, translocation|cerebral cortex cell migration|cerebral cortex neuron differentiation|positive regulation of multicellular organism growth|protein import into peroxisome membrane|cell development|neuromuscular process|protein tetramerization|negative regulation of protein homotetramerization|",peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|peroxisome matrix targeting signal-1 binding|peroxisome matrix targeting signal-1 binding|protein binding|protein C-terminus binding|enzyme binding|small GTPase binding|protein N-terminus binding|,0,0,0,1,2,1.14,2,1.06,0.459,-1.6,4
ENSMUSG00000047617,BC029214,cDNA sequence BC029214,extracellular vesicular exosome|,biological_process|,molecular_function|,1,-2.7,1.13,0,0,0,-2.7,1.05,0.462,-5,1.5
ENSMUSG00000027678,NCOA3,nuclear receptor coactivator 3,nucleus|cytoplasm|,"transcription, DNA-templated|positive regulation of gene expression|histone acetylation|histone acetylation|androgen receptor signaling pathway|multicellular organism growth|receptor transactivation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|developmental growth|vagina development|labyrinthine layer morphogenesis|mammary gland branching involved in thelarche|regulation of RNA biosynthetic process|",chromatin binding|transcription coactivator activity|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|signal transducer activity|protein binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nuclear hormone receptor binding|thyroid hormone receptor binding|protein dimerization activity|protein N-terminus binding|androgen receptor binding|,10,-2.3,0.00976,10,-1.4,1.36,-1.7,1.05,0.462,-6.3,6.9
ENSMUSG00000045991,ONECUT2,one cut homeobox 2,nucleus|,"liver development|regulation of cell-matrix adhesion|epithelial cell development|transcription, DNA-templated|organ morphogenesis|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endocrine pancreas development|cilium assembly|cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|peripheral nervous system neuron development|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|,1,-2.7,1.13,0,0,0,-2.7,1.05,0.462,-5,1.5
ENSMUSG00000027104,ATF2,activating transcription factor 2,nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|site of double-strand break|,"toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|outflow tract morphogenesis|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|response to osmotic stress|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|histone acetylation|histone acetylation|intra-S DNA damage checkpoint|positive regulation of transforming growth factor beta2 production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|adipose tissue development|positive regulation of mitochondrial membrane permeability involved in apoptotic process|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|cAMP response element binding protein binding|protein kinase binding|cAMP response element binding|metal ion binding|protein heterodimerization activity|,9,-2.3,1.66,8,1.8,0.199,-1,1.05,0.462,-5.1,3.7
ENSMUSG00000035177,NLRP2,"NLR family, pyrin domain containing 2",cytoplasm|,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of interleukin-1 beta secretion|,protein binding|ATP binding|Pyrin domain binding|,10,2.8,2.76,10,-0.3,0.122,2.4,1.05,0.462,-6,7.4
ENSMUSG00000064179,TNNT1,"troponin T type 1 (skeletal, slow)",cytosol|troponin complex|troponin complex|,skeletal muscle contraction|muscle filament sliding|slow-twitch skeletal muscle fiber contraction|negative regulation of muscle contraction|,tropomyosin binding|troponin T binding|,8,2,1.55,9,-0.4,0.12,1.5,1.04,0.464,-2.8,5.8
ENSMUSG00000030653,PDE2A,"phosphodiesterase 2A, cGMP-stimulated",nucleus|cytoplasm|mitochondrial matrix|endoplasmic reticulum|Golgi apparatus|cytosol|cytosol|plasma membrane|plasma membrane|axon|dendrite|presynaptic membrane|perinuclear region of cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|cAMP catabolic process|cAMP catabolic process|protein targeting to mitochondrion|blood coagulation|metabolic process|cAMP-mediated signaling|cGMP-mediated signaling|monocyte differentiation|negative regulation of cAMP biosynthetic process|negative regulation of protein import into nucleus, translocation|cellular response to drug|cellular response to drug|cellular response to macrophage colony-stimulating factor stimulus|negative regulation of vascular permeability|positive regulation of vascular permeability|cGMP catabolic process|positive regulation of inflammatory response|establishment of endothelial barrier|calcium ion transmembrane transport|cellular response to mechanical stimulus|cellular response to cGMP|cellular response to transforming growth factor beta stimulus|cellular response to granulocyte macrophage colony-stimulating factor stimulus|",cyclic-nucleotide phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|calcium channel activity|protein binding|drug binding|drug binding|cAMP binding|cGMP binding|cGMP binding|TPR domain binding|protein homodimerization activity|metal ion binding|,10,-0.5,0.395,10,-1,0.924,-0.7,1.04,0.464,-10.1,4.3
ENSMUSG00000058927,GM10053,"cytochrome c, somatic pseudogene",None,None,None,3,2.3,1.4,4,-1.6,0.897,-2.6,1.04,0.464,-6,4.7
ENSMUSG00000020716,NF1,neurofibromin 1,nucleus|nucleolus|cytoplasm|cytoplasm|membrane|axon|dendrite|intrinsic component of the cytoplasmic side of the plasma membrane|,"MAPK cascade|osteoblast differentiation|metanephros development|response to hypoxia|liver development|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|regulation of cell-matrix adhesion|negative regulation of cell-matrix adhesion|negative regulation of protein kinase activity|cell communication|Ras protein signal transduction|negative regulation of neuroblast proliferation|brain development|peripheral nervous system development|heart development|skeletal muscle tissue development|visual learning|extrinsic apoptotic signaling pathway via death domain receptors|Schwann cell development|phosphatidylinositol 3-kinase signaling|negative regulation of angiogenesis|spinal cord development|forebrain astrocyte development|neural tube development|cerebral cortex development|myelination in peripheral nervous system|actin cytoskeleton organization|extracellular matrix organization|collagen fibril organization|adrenal gland development|negative regulation of cell migration|regulation of synaptic transmission, GABAergic|regulation of Ras GTPase activity|positive regulation of Ras GTPase activity|positive regulation of Ras GTPase activity|positive regulation of Ras GTPase activity|negative regulation of Rac protein signal transduction|wound healing|negative regulation of transcription factor import into nucleus|positive regulation of apoptotic process|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of MAPK cascade|pigmentation|positive regulation of neuron apoptotic process|regulation of blood vessel endothelial cell migration|regulation of bone resorption|negative regulation of osteoclast differentiation|regulation of glial cell differentiation|positive regulation of adenylate cyclase activity|regulation of angiogenesis|negative regulation of Ras protein signal transduction|negative regulation of neurotransmitter secretion|negative regulation of fibroblast proliferation|regulation of long-term neuronal synaptic plasticity|sympathetic nervous system development|camera-type eye morphogenesis|negative regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|smooth muscle tissue development|artery morphogenesis|forebrain morphogenesis|cognition|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|",Ras GTPase activator activity|protein binding|phosphatidylethanolamine binding|phosphatidylcholine binding|,10,-4.7,0.487,9,-2.3,1.42,-4.5,1.04,0.464,-8.7,3.1
ENSMUSG00000020782,LLGL2,lethal giant larvae homolog 2 (Drosophila),cytoplasm|,exocytosis|cell cycle|regulation of establishment or maintenance of cell polarity|cell division|,protein binding|PDZ domain binding|,9,2.5,3.34,9,-1.5,0.275,2.2,1.04,0.464,-3.9,7.6
ENSMUSG00000076745,TCRG-V4,"T cell receptor gamma, variable 4",None,None,None,10,-5,1.01,10,-2.7,0.765,-4.8,1.04,0.464,-10.4,4.8
ENSMUSG00000029924,SLC37A3,"solute carrier family 37, member 3",integral component of membrane|,carbohydrate transport|transmembrane transport|,transporter activity|,1,-2.7,1.12,0,0,0,-2.7,1.04,0.464,-5,1.5
ENSMUSG00000050332,AMER1,APC membrane recruitment protein 1,nucleus|cytosol|plasma membrane|,Wnt signaling pathway|bone development|adipose tissue development|regulation of canonical Wnt signaling pathway|mesenchymal cell differentiation involved in kidney development|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|,"protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|beta-catenin binding|",10,-0.5,0.185,10,6.2,4.34,6.1,1.04,0.464,-1.5,12.6
ENSMUSG00000032261,SH3BGRL2,SH3 domain binding glutamate-rich protein like 2,nucleus|extracellular vesicular exosome|,None,SH3 domain binding|,0,0,0,1,2,1.12,2,1.04,0.464,-1.6,4
ENSMUSG00000034543,MORC2A,microrchidia 2A,nucleus|cytoplasm|,biological_process|,zinc ion binding|metal ion binding|,0,0,0,1,-2.5,1.11,-2.5,1.03,0.466,-5,1.5
ENSMUSG00000073658,CRYGB,"crystallin, gamma B",cellular_component|nucleus|cytoplasm|,visual perception|lens fiber cell morphogenesis|,structural constituent of eye lens|,0,0,0,1,-2.5,1.11,-2.5,1.03,0.466,-5,1.5
ENSMUSG00000000861,BCL11A,B-cell CLL/lymphoma 11A (zinc finger protein),nucleus|cytoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|positive regulation of neuron projection development|negative regulation of neuron projection development|protein sumoylation|B cell differentiation|T cell differentiation|negative regulation of axon extension|negative regulation of protein homooligomerization|positive regulation of transcription from RNA polymerase II promoter|negative regulation of collateral sprouting|positive regulation of collateral sprouting|regulation of dendrite development|negative regulation of dendrite development|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription corepressor activity|protein homodimerization activity|metal ion binding|protein heterodimerization activity|,10,0.8,0.187,10,-1.3,1.55,-0.8,1.03,0.466,-4.6,2.8
ENSMUSG00000021033,GSTZ1,glutathione S-transferase zeta 1,mitochondrion|cytosol|,L-phenylalanine catabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|glutathione metabolic process|xenobiotic metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|oxidation-reduction process|glutathione derivative biosynthetic process|,glutathione transferase activity|glutathione peroxidase activity|protein binding|maleylacetoacetate isomerase activity|maleylacetoacetate isomerase activity|protein homodimerization activity|,10,1,0.446,10,2.2,0.862,1.1,1.03,0.466,-3.6,5.4
ENSMUSG00000058665,EN1,engrailed homeobox 1,nucleus|membrane|,skeletal system development|anatomical structure morphogenesis|dorsal/ventral pattern formation|proximal/distal pattern formation|midbrain development|hindbrain development|midbrain-hindbrain boundary development|embryonic forelimb morphogenesis|response to cocaine|pigmentation|positive regulation of transcription from RNA polymerase II promoter|neuron development|,sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,0,0,0,1,-2.5,1.11,-2.5,1.03,0.466,-5,1.5
ENSMUSG00000049515,ESPNL,espin-like,None,None,None,1,2,1.39,1,-2.7,1.52,-2.6,1.03,0.466,-5,4.4
ENSMUSG00000025952,CRYGC,"crystallin, gamma C",nucleus|cytoplasm|,visual perception|camera-type eye development|,structural constituent of eye lens|protein binding|,0,0,0,1,-2.5,1.11,-2.5,1.03,0.466,-5,1.5
ENSMUSG00000059343,ALDOART1,"aldolase 1 A, retrogene 1",sperm fibrous sheath|,biological_process|,molecular_function|,1,-3.2,1.6,1,0.1,0.00079,-3.1,1.02,0.469,-6,1.4
ENSMUSG00000026082,REV1,"REV1, polymerase (DNA directed)",nucleoplasm|,DNA replication|DNA-dependent DNA replication|DNA-dependent DNA replication|DNA repair|response to UV|error-prone translesion synthesis|,magnesium ion binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|deoxycytidyl transferase activity|,10,0.8,0.371,10,-1.6,1.97,-1.5,1.02,0.469,-5.4,2.7
ENSMUSG00000048960,PREX2,"phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2",None,G-protein coupled receptor signaling pathway|positive regulation of Rac GTPase activity|intracellular signal transduction|,Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity|,10,2.1,1.67,10,-0.5,0.247,-0.8,1.02,0.469,-8,5.3
ENSMUSG00000026887,MRRF,mitochondrial ribosome recycling factor,mitochondrion|,translation|ribosome disassembly|,None,0,0,0,1,2,1.1,2,1.02,0.469,-1.6,4
ENSMUSG00000049670,MORN4,MORN repeat containing 4,None,None,None,1,1.8,1.1,0,0,0,1.8,1.02,0.469,-1.6,4
ENSMUSG00000026360,RGS2,regulator of G-protein signaling 2,nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|cytoplasmic side of plasma membrane|neuron projection|,regulation of translation|cell cycle|spermatogenesis|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of phospholipase activity|negative regulation of cardiac muscle hypertrophy|positive regulation of microtubule polymerization|termination of G-protein coupled receptor signaling pathway|negative regulation of MAP kinase activity|positive regulation of GTPase activity|negative regulation of G-protein coupled receptor protein signaling pathway|brown fat cell differentiation|relaxation of cardiac muscle|relaxation of vascular smooth muscle|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|,GTPase activator activity|protein binding|calmodulin binding|beta-tubulin binding|,10,-2.1,0.438,10,-1.3,0.878,-1.8,1.02,0.469,-6.8,5.4
ENSMUSG00000022032,SCARA5,"scavenger receptor class A, member 5",integral component of plasma membrane|cell surface|,cellular iron ion homeostasis|endocytosis|receptor-mediated endocytosis|receptor-mediated endocytosis|regulation of gene expression|regulation of blood coagulation|cellular response to heat|iron ion transmembrane transport|protein homotrimerization|,scavenger receptor activity|ferritin receptor activity|,0,0,0,1,2,1.1,2,1.02,0.469,-1.6,4
ENSMUSG00000076586,IGKV8-21,immunoglobulin kappa variable 8-21,None,None,None,1,1.8,1.1,0,0,0,1.8,1.02,0.469,-1.6,4
ENSMUSG00000079597,GM5483,predicted gene 5483,None,None,None,8,-3.3,1.06,8,0.6,0.298,1.2,1.02,0.469,-8.2,4.7
ENSMUSG00000078249,HMGA1-RS1,"high mobility group AT-hook I, related sequence 1",nucleus|senescence-associated heterochromatin focus|,"DNA catabolic process, endonucleolytic|regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|DNA-(apurinic or apyrimidinic site) lyase activity|transcription factor binding|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|retinoid X receptor binding|5'-deoxyribose-5-phosphate lyase activity|,9,-3.4,1.67,10,-0.9,0.637,-1.1,1.01,0.471,-6.5,2.5
ENSMUSG00000021364,ELOVL2,ELOVL fatty acid elongase 2,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,"unsaturated fatty acid biosynthetic process|triglyceride biosynthetic process|unsaturated fatty acid metabolic process|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|cellular lipid metabolic process|small molecule metabolic process|",protein binding|fatty acid elongase activity|,10,1.7,0.783,10,2.2,0.354,1.9,1,0.473,-6.8,6.6
ENSMUSG00000026743,MLLT10,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10",nucleus|cytoplasm|,"transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|,10,-0.4,0.154,10,2.7,3.32,1.9,0.999,0.473,-6.6,8
ENSMUSG00000033671,CEP350,centrosomal protein 350kDa,nucleus|cytoplasm|centrosome|spindle|membrane|,microtubule anchoring|,microtubule binding|,10,-3.4,2.44,10,-0.4,0.0612,-1.2,0.999,0.473,-9,3.3
ENSMUSG00000033075,SENP1,SUMO1/sentrin specific peptidase 1,nucleus|nucleoplasm|cytoplasm|focal adhesion|nuclear membrane|,proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of definitive erythrocyte differentiation|protein sumoylation|protein desumoylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|cellular protein metabolic process|positive regulation of transcription from RNA polymerase II promoter|apoptotic signaling pathway|,endopeptidase activity|protein binding|SUMO-specific protease activity|,10,3.4,1.74,10,0.6,0.191,0.7,0.996,0.474,-7.1,8
ENSMUSG00000036526,CARD11,"caspase recruitment domain family, member 11",cytoplasm|cytosol|plasma membrane|plasma membrane|T cell receptor complex|membrane raft|,positive regulation of cytokine production|positive regulation of B cell proliferation|T cell costimulation|Fc-epsilon receptor signaling pathway|positive regulation of T cell proliferation|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|thymic T cell selection|positive regulation of interleukin-2 biosynthetic process|innate immune response|regulation of B cell differentiation|regulation of T cell differentiation|nucleotide phosphorylation|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|,guanylate kinase activity|protein binding|CARD domain binding|,10,3.2,3.91,10,-0.1,0.0167,3,0.994,0.474,-4.2,9
ENSMUSG00000030611,MRPS11,mitochondrial ribosomal protein S11,mitochondrion|mitochondrial small ribosomal subunit|mitochondrial small ribosomal subunit|,"translation|DNA damage response, detection of DNA damage|",structural constituent of ribosome|poly(A) RNA binding|,10,1.2,0.732,10,0.6,0.448,0.8,0.994,0.474,-6.3,5
ENSMUSG00000033047,EIF3L,"eukaryotic translation initiation factor 3, subunit L",fibrillar center|nucleoplasm|eukaryotic translation initiation factor 3 complex|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|,formation of translation preinitiation complex|translational initiation|translational initiation|regulation of translational initiation|,translation initiation factor activity|translation initiation factor activity|protein binding|poly(A) RNA binding|,1,-2.6,1.07,0,0,0,-2.6,0.993,0.475,-5,1.5
ENSMUSG00000043639,RBM20,RNA binding motif protein 20,nucleus|,mRNA processing|heart development|RNA splicing|positive regulation of RNA splicing|,nucleotide binding|RNA binding|zinc ion binding|,1,-2.6,1.07,0,0,0,-2.6,0.993,0.475,-5,1.5
ENSMUSG00000019917,10-Sep,septin 10,septin complex|,cell cycle|cell division|,GTP binding|,10,-1.7,2.64,10,0,0,-1.3,0.993,0.475,-6.5,1.7
ENSMUSG00000029190,D5ERTD579E,"DNA segment, Chr 5, ERATO Doi 579, expressed",cellular_component|,biological_process|,nucleotide binding|molecular_function|ATP binding|,1,-2.6,1.07,0,0,0,-2.6,0.993,0.475,-5,1.5
ENSMUSG00000051495,IRF2BP2,interferon regulatory factor 2 binding protein 2,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",metal ion binding|,1,-2.6,1.07,0,0,0,-2.6,0.993,0.475,-5,1.5
ENSMUSG00000023892,ZFP51,zinc finger protein 51,None,"regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|metal ion binding|,1,-2.6,1.07,0,0,0,-2.6,0.993,0.475,-5,1.5
ENSMUSG00000094840,A630081J09RIK,RIKEN cDNA A630081J09 gene,cellular_component|,biological_process|,molecular_function|,10,-2.9,2.27,10,-1,0.471,-1.4,0.993,0.475,-8.5,2.3
ENSMUSG00000020184,MDM2,"MDM2 proto-oncogene, E3 ubiquitin protein ligase",nucleus|nucleus|nucleoplasm|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|nuclear body|endocytic vesicle membrane|protein complex|synapse|,"negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|traversing start control point of mitotic cell cycle|epidermal growth factor receptor signaling pathway|synaptic transmission|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|response to carbohydrate|response to iron ion|positive regulation of gene expression|negative regulation of protein processing|viral process|protein ubiquitination|peptidyl-lysine modification|protein destabilization|response to magnesium ion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein localization to nucleus|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|response to cocaine|response to drug|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to morphine|negative regulation of DNA damage response, signal transduction by p53 class mediator|innate immune response|establishment of protein localization|response to ether|negative regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|response to antibiotic|positive regulation of protein export from nucleus|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|cellular response to hydrogen peroxide|negative regulation of cell cycle arrest|cellular response to acid|cellular response to antibiotic|cellular response to vitamin B1|cellular response to alkaloid|cellular response to peptide hormone stimulus|cellular response to estrogen stimulus|cellular response to hypoxia|cellular response to UV-C|",p53 binding|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|enzyme binding|ubiquitin protein ligase binding|identical protein binding|peroxisome proliferator activated receptor binding|scaffold protein binding|,7,-1.1,1.38,7,1.9,0.895,-0.9,0.993,0.475,-4.7,4.4
ENSMUSG00000057329,BCL2,B-cell CLL/lymphoma 2,nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|nuclear membrane|myelin sheath|pore complex|,"protein polyubiquitination|response to acid|ossification|ovarian follicle development|metanephros development|branching involved in ureteric bud morphogenesis|behavioral fear response|B cell homeostasis|release of cytochrome c from mitochondria|release of cytochrome c from mitochondria|regulation of cell-matrix adhesion|lymphoid progenitor cell differentiation|B cell lineage commitment|response to ischemia|renal system process|protein dephosphorylation|melanin metabolic process|regulation of nitrogen utilization|apoptotic process|apoptotic process|humoral immune response|cellular response to DNA damage stimulus|actin filament organization|axonogenesis|female pregnancy|cell aging|male gonad development|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to radiation|response to toxic substance|post-embryonic development|response to iron ion|response to UV-B|response to gamma radiation|negative regulation of autophagy|negative regulation of calcium ion transport into cytosol|regulation of glycoprotein biosynthetic process|mesenchymal cell development|positive regulation of neuron maturation|positive regulation of smooth muscle cell migration|cell growth|single organismal cell-cell adhesion|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cochlear nucleus development|gland morphogenesis|regulation of transmembrane transporter activity|negative regulation of ossification|positive regulation of cell growth|negative regulation of cell growth|melanocyte differentiation|negative regulation of cell migration|positive regulation of B cell proliferation|hair follicle morphogenesis|axon regeneration|regulation of protein stability|endoplasmic reticulum calcium ion homeostasis|glomerulus development|negative regulation of cellular pH reduction|negative regulation of myeloid cell apoptotic process|T cell differentiation in thymus|positive regulation of peptidyl-serine phosphorylation|negative regulation of osteoblast proliferation|response to cytokine|response to nicotine|organ growth|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|positive regulation of multicellular organism growth|B cell proliferation|cellular response to glucose starvation|response to drug|response to drug|response to hydrogen peroxide|T cell homeostasis|negative regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|CD8-positive, alpha-beta T cell lineage commitment|regulation of protein homodimerization activity|regulation of protein heterodimerization activity|negative regulation of neuron apoptotic process|ear development|regulation of viral genome replication|innate immune response|positive regulation of melanocyte differentiation|negative regulation of mitotic cell cycle|negative regulation of retinal cell programmed cell death|regulation of mitochondrial membrane permeability|focal adhesion assembly|spleen development|thymus development|digestive tract morphogenesis|developmental growth|oocyte development|positive regulation of skeletal muscle fiber development|pigment granule organization|homeostasis of number of cells within a tissue|B cell receptor signaling pathway|response to glucocorticoid|neuron apoptotic process|defense response to virus|regulation of mitochondrial membrane potential|negative regulation of mitochondrial depolarization|regulation of calcium ion transport|transmembrane transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to organic substance|cellular response to hypoxia|reactive oxygen species metabolic process|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of anoikis|negative regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|",protease binding|protein binding|transcription factor binding|channel activity|channel inhibitor activity|ubiquitin protein ligase binding|identical protein binding|protein homodimerization activity|sequence-specific DNA binding|protein heterodimerization activity|BH3 domain binding|protein phosphatase 2A binding|,10,5.4,2.09,10,-3.7,3.51,-0.9,0.993,0.475,-9.5,9
ENSMUSG00000023930,CRISP2,cysteine-rich secretory protein 2,extracellular space|,single organismal cell-cell adhesion|,None,10,-1,1.34,10,-0.2,0.0432,-0.7,0.99,0.475,-5.3,3.5
ENSMUSG00000047766,LRRC49,leucine rich repeat containing 49,cytoplasm|microtubule|,None,None,0,0,0,1,2,1.06,2,0.985,0.477,-1.6,4
ENSMUSG00000068798,RAP1A,"RAP1A, member of RAS oncogene family",cytoplasm|early endosome|late endosome|cytosol|plasma membrane|cell junction|guanyl-nucleotide exchange factor complex|perinuclear region of cytoplasm|extracellular vesicular exosome|,activation of MAPKK activity|energy reserve metabolic process|GTP catabolic process|signal transduction|blood coagulation|positive regulation of neuron projection development|protein transport|platelet activation|Rap protein signal transduction|positive regulation of Rap GTPase activity|nerve growth factor signaling pathway|small molecule metabolic process|positive regulation of protein kinase activity|neurotrophin TRK receptor signaling pathway|regulation of insulin secretion|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|regulation of cell junction assembly|cellular response to nerve growth factor stimulus|positive regulation of vasculogenesis|,GTPase activity|protein binding|GTP binding|protein transporter activity|Ras GTPase binding|Rap guanyl-nucleotide exchange factor activity|protein complex binding|,10,0,0,10,-1.5,1.64,-1.5,0.985,0.477,-7.5,4.2
ENSMUSG00000050912,TMEM123,transmembrane protein 123,external side of plasma membrane|integral component of membrane|,oncosis|,receptor activity|,10,-0.7,0.408,10,-0.9,0.686,-0.8,0.985,0.477,-5.5,2.8
ENSMUSG00000038807,RAP1GAP2,RAP1 GTPase activating protein 2,cytoplasm|centrosome|cytosol|nuclear membrane|perinuclear region of cytoplasm|,positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,0,0,0,1,2,1.06,2,0.985,0.477,-1.6,4
ENSMUSG00000062908,ACADM,"acyl-CoA dehydrogenase, C-4 to C-12 straight chain",nucleus|mitochondrion|mitochondrial matrix|axon|extracellular vesicular exosome|,"liver development|glycogen biosynthetic process|regulation of gluconeogenesis|fatty acid beta-oxidation|fatty acid beta-oxidation|response to cold|post-embryonic development|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA dehydrogenase|response to starvation|cellular lipid metabolic process|small molecule metabolic process|carnitine biosynthetic process|medium-chain fatty acid metabolic process|medium-chain fatty acid catabolic process|cardiac muscle cell differentiation|oxidation-reduction process|",acyl-CoA dehydrogenase activity|acyl-CoA dehydrogenase activity|acyl-CoA dehydrogenase activity|identical protein binding|flavin adenine dinucleotide binding|medium-chain-acyl-CoA dehydrogenase activity|,9,-0.9,1.09,10,-1.4,0.169,-1.1,0.984,0.477,-6.1,2.3
ENSMUSG00000078941,TAF9,"TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa",PCAF complex|nucleoplasm|transcription factor TFIID complex|STAGA complex|transcription factor TFTC complex|pre-snoRNP complex|MLL1 complex|,chromatin organization|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|cellular response to DNA damage stimulus|gene expression|viral process|positive regulation of cell growth|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription from RNA polymerase II promoter|protein stabilization|positive regulation of response to cytokine stimulus|response to interleukin-1|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|,p53 binding|DNA binding|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|activating transcription factor binding|transcription regulatory region DNA binding|protein heterodimerization activity|C2H2 zinc finger domain binding|,10,-3.8,0.824,10,-0.5,0.548,-3.6,0.982,0.478,-7.8,0.8
ENSMUSG00000053129,GSX1,GS homeobox 1,nucleus|,"transcription, DNA-templated|spinal cord association neuron differentiation|hypothalamus development|adenohypophysis development|positive regulation of transcription from RNA polymerase II promoter|neuron fate commitment|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-2.6,1.06,0,0,0,-2.6,0.981,0.478,-5,1.5
ENSMUSG00000025323,SP4,Sp4 transcription factor,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|regulation of heart contraction|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|metal ion binding|,1,-2.6,1.06,0,0,0,-2.6,0.981,0.478,-5,1.5
ENSMUSG00000026049,TEX30,testis expressed 30,None,None,None,10,-0.9,0.413,9,-1.2,0.733,-1.1,0.978,0.479,-6.1,2.3
ENSMUSG00000053175,BCL3,B-cell CLL/lymphoma 3,nucleus|cytoplasm|Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|protein complex|intercellular bridge|perinuclear region of cytoplasm|,"protein import into nucleus, translocation|follicular dendritic cell differentiation|marginal zone B cell differentiation|humoral immune response mediated by circulating immunoglobulin|germinal center formation|transcription, DNA-templated|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|response to virus|response to UV-C|antimicrobial humoral response|extracellular matrix organization|DNA damage response, signal transduction by p53 class mediator|positive regulation of interferon-gamma production|T-helper 1 type immune response|regulation of NF-kappaB import into nucleus|negative regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|defense response to protozoan|regulation of apoptotic process|negative regulation of apoptotic process|T-helper 2 cell differentiation|positive regulation of interleukin-10 biosynthetic process|negative regulation of interleukin-8 biosynthetic process|positive regulation of translation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|spleen development|regulation of DNA binding|maintenance of protein location in nucleus|","DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein binding, bridging|",10,-0.5,0.631,10,-0.6,0.441,-0.5,0.977,0.479,-8.9,2.4
ENSMUSG00000019987,ARG1,arginase 1,extracellular space|nucleus|cytoplasm|cytosol|neuron projection|neuronal cell body|extracellular vesicular exosome|,urea cycle|urea cycle|liver development|positive regulation of endothelial cell proliferation|arginine catabolic process|response to herbicide|response to manganese ion|response to zinc ion|response to selenium ion|regulation of L-arginine import|response to amine|lung development|collagen biosynthetic process|response to vitamin A|response to vitamin E|cellular nitrogen compound metabolic process|response to drug|response to amino acid|small molecule metabolic process|response to cadmium ion|response to axon injury|response to methylmercury|mammary gland involution|maternal process involved in female pregnancy|protein homotrimerization|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|cellular response to interleukin-4|cellular response to glucagon stimulus|cellular response to dexamethasone stimulus|cellular response to transforming growth factor beta stimulus|,arginase activity|manganese ion binding|,10,4.9,3.37,10,-0.2,0.0629,3.9,0.977,0.479,-2.5,9.8
ENSMUSG00000031529,TNKS,"tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase","Golgi membrane|pericentriolar material|chromosome, centromeric region|chromosome, telomeric region|nuclear chromosome, telomeric region|spindle pole|nucleus|nuclear pore|Golgi apparatus|nuclear membrane|nuclear membrane|","protein polyubiquitination|protein ADP-ribosylation|mitotic spindle organization|mitotic nuclear division|protein transport|Wnt signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|negative regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|mRNA transport|spindle assembly|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|",NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding|,10,-0.8,0.494,10,-0.8,0.57,-0.8,0.977,0.479,-4.4,2.3
ENSMUSG00000097704,GM26741,N/A,None,None,None,1,-3.2,1.56,1,1.8,0.939,-3,0.976,0.479,-6,3.4
ENSMUSG00000031994,ADAMTS8,"ADAM metallopeptidase with thrombospondin type 1 motif, 8",proteinaceous extracellular matrix|extracellular matrix|,proteolysis|negative regulation of cell proliferation|phosphate ion transmembrane transport|,metalloendopeptidase activity|integrin binding|heparin binding|metallopeptidase activity|zinc ion binding|low affinity phosphate transmembrane transporter activity|,0,0,0,2,1.3,1.05,1.3,0.974,0.48,-1.6,3
ENSMUSG00000091387,GCNT4,"glucosaminyl (N-acetyl) transferase 4, core 2",Golgi membrane|integral component of membrane|,inter-male aggressive behavior|carbohydrate metabolic process|protein O-linked glycosylation|O-glycan processing|thyroid hormone metabolic process|post-translational protein modification|cellular protein metabolic process|tissue morphogenesis|homeostasis of number of cells|kidney morphogenesis|,"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|",10,0.2,0.0219,10,-1.5,1.72,-1.5,0.972,0.48,-6.7,3.2
ENSMUSG00000030616,SYTL2,synaptotagmin-like 2,nucleus|cytoplasm|Golgi apparatus|plasma membrane|membrane|extrinsic component of plasma membrane|melanosome|exocytic vesicle|,intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|negative regulation of phosphatase activity|vesicle-mediated transport|,"phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|Rab GTPase binding|phosphatase binding|neurexin family protein binding|",0,0,0,2,1.3,1.05,1.3,0.972,0.48,-1.6,3
ENSMUSG00000026281,DTYMK,deoxythymidylate kinase (thymidylate kinase),mitochondrial intermembrane space|mitochondrial matrix|cytosol|,dTDP biosynthetic process|dTTP biosynthetic process|cell cycle|cell proliferation|nucleobase-containing small molecule interconversion|response to estrogen|small molecule metabolic process|myoblast differentiation|response to cadmium ion|nucleotide phosphorylation|nucleotide phosphorylation|nucleotide phosphorylation|nucleoside monophosphate phosphorylation|nucleobase-containing small molecule metabolic process|cellular response to growth factor stimulus|,thymidylate kinase activity|ATP binding|nucleoside phosphate kinase activity|,10,-0.7,0.752,10,-2.7,0.58,-0.5,0.971,0.48,-7.4,1.6
ENSMUSG00000040033,STAT2,"signal transducer and activator of transcription 2, 113kDa",nucleoplasm|cytoplasm|cytosol|plasma membrane|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|JAK-STAT cascade|viral process|cytokine-mediated signaling pathway|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|",DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|calcium ion binding|protein binding|identical protein binding|,1,1.7,1.05,0,0,0,1.7,0.971,0.48,-1.6,4
ENSMUSG00000025758,PLK4,polo-like kinase 4,nucleolus|centrosome|centriole|cytosol|cleavage furrow|deuterosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphorylation|centriole replication|peptidyl-tyrosine phosphorylation|positive regulation of centriole replication|trophoblast giant cell differentiation|de novo centriole assembly|,protein serine/threonine kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|identical protein binding|,1,1.7,1.05,0,0,0,1.7,0.971,0.48,-1.6,4
ENSMUSG00000037296,LSM1,"LSM1, U6 small nuclear RNA associated",nucleus|cytoplasm|cytosol|ribonucleoprotein complex|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|RNA splicing, via transesterification reactions|mRNA processing|RNA splicing|gene expression|RNA metabolic process|mRNA metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|",protein binding|poly(A) RNA binding|,1,-2.3,0.856,1,-1.5,0.314,-2,0.971,0.48,-5,1.5
ENSMUSG00000038866,ZCCHC2,"zinc finger, CCHC domain containing 2",cytoplasm|,None,nucleic acid binding|zinc ion binding|phosphatidylinositol binding|,1,-2.6,1.04,0,0,0,-2.6,0.969,0.481,-5,1.5
ENSMUSG00000020173,COBL,cordon-bleu WH2 repeat protein,ruffle|actin filament|plasma membrane|cell cortex|membrane|axon|dendrite|neuronal cell body|dendritic growth cone|axonal growth cone|perinuclear region of cytoplasm|,embryonic axis specification|somite specification|neural tube closure|liver development|actin filament polymerization|notochord development|floor plate development|digestive tract development|collateral sprouting in absence of injury|actin filament network formation|positive regulation of dendrite development|,actin monomer binding|,1,-2.6,1.04,0,0,0,-2.6,0.969,0.481,-5,1.5
ENSMUSG00000020807,4933427D14RIK,RIKEN cDNA 4933427D14 gene,cytoplasm|centrosome|,biological_process|,molecular_function|,0,0,0,1,-2.4,1.04,-2.4,0.968,0.481,-4,1.6
ENSMUSG00000039760,IL22RA2,"interleukin 22 receptor, alpha 2",extracellular space|cytosol|,cytokine-mediated signaling pathway|regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of inflammatory response|,interleukin-22 binding|interleukin-22 receptor activity|,0,0,0,1,-2.4,1.04,-2.4,0.968,0.481,-4,1.6
ENSMUSG00000026768,ITGA8,"integrin, alpha 8",plasma membrane|integrin complex|postsynaptic density|dendritic spine membrane|integrin alpha8-beta1 complex|perikaryon|apical part of cell|,metanephros development|cell-matrix adhesion|integrin-mediated signaling pathway|brain development|memory|single organismal cell-cell adhesion|cell projection organization|extracellular matrix organization|positive regulation of transforming growth factor beta receptor signaling pathway|inner ear morphogenesis|establishment of protein localization|smooth muscle tissue development|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|,metal ion binding|,10,0,0,10,-1.4,1.25,-1.3,0.963,0.482,-8.5,4.9
ENSMUSG00000056228,CARS2,"cysteinyl-tRNA synthetase 2, mitochondrial (putative)",mitochondrial matrix|cytosol|,tRNA aminoacylation for protein translation|cysteinyl-tRNA aminoacylation|gene expression|,cysteine-tRNA ligase activity|ATP binding|metal ion binding|,10,5.1,0.772,10,-2.2,0.923,-2.1,0.961,0.483,-7.4,8.7
ENSMUSG00000029681,BCL7B,B-cell CLL/lymphoma 7B,cellular_component|,biological_process|,actin binding|,10,-3.5,1.61,10,-0.4,0.167,-1.1,0.961,0.483,-8.3,1.6
ENSMUSG00000022353,MTSS1,metastasis suppressor 1,ruffle|cytoplasm|actin cytoskeleton|endocytic vesicle|,cellular component movement|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|microspike assembly|actin cytoskeleton organization|actin filament polymerization|filopodium assembly|negative regulation of epithelial cell proliferation|renal tubule morphogenesis|cellular response to fluid shear stress|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|epithelial cell proliferation involved in renal tubule morphogenesis|,actin monomer binding|receptor binding|protein binding|cytoskeletal adaptor activity|SH3 domain binding|identical protein binding|,10,1.1,1.53,10,0,0,0.7,0.958,0.483,-5.9,5
ENSMUSG00000038304,CD160,CD160 molecule,plasma membrane|anchored component of plasma membrane|,cellular defense response|cell surface receptor signaling pathway|cell proliferation|regulation of immune response|defense response to Gram-negative bacterium|,receptor activity|receptor binding|MHC class I receptor activity|,10,-2.8,0.373,10,-0.9,1.21,-2.1,0.958,0.483,-7.5,1.8
ENSMUSG00000056394,LIG1,"ligase I, DNA, ATP-dependent",nucleus|nucleus|nucleoplasm|chromosome|mitochondrion|Golgi apparatus|intracellular membrane-bounded organelle|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA metabolic process|DNA strand elongation involved in DNA replication|lagging strand elongation|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA gap filling|double-strand break repair|double-strand break repair via nonhomologous end joining|anatomical structure morphogenesis|telomere maintenance via semi-conservative replication|response to hydrogen peroxide|DNA ligation involved in DNA repair|cell division|",DNA binding|DNA ligase activity|DNA ligase (ATP) activity|ATP binding|metal ion binding|,9,0,0,9,2,3.05,1.2,0.958,0.483,-6.5,6
ENSMUSG00000049511,HTR1B,"5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled",cytoplasm|plasma membrane|integral component of plasma membrane|,"G-protein coupled receptor internalization|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting serotonin receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|synaptic transmission|regulation of dopamine secretion|negative regulation of serotonin secretion|negative regulation of cAMP biosynthetic process|negative regulation of synaptic transmission, GABAergic|cellular response to drug|response to cocaine|vasoconstriction|drinking behavior|response to ethanol|bone remodeling|regulation of behavior|response to mineralocorticoid|negative regulation of synaptic transmission, glutamatergic|cellular response to alkaloid|cellular response to temperature stimulus|",serotonin receptor activity|drug binding|serotonin binding|,1,-2.6,1.03,0,0,0,-2.6,0.957,0.484,-5,1.5
ENSMUSG00000035845,ALG12,"ALG12, alpha-1,6-mannosyltransferase",endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|,protein folding|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|mannosylation|mannosylation|,"alpha-1,6-mannosyltransferase activity|dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity|",10,0.9,0.9,10,-0.8,0.87,-1.6,0.956,0.484,-6.5,2.9
ENSMUSG00000003923,TFAM,"transcription factor A, mitochondrial",nucleus|mitochondrion|mitochondrial matrix|mitochondrial nucleoid|,"DNA-dependent DNA replication|regulation of transcription from RNA polymerase I promoter|transcription from mitochondrial promoter|transcription from mitochondrial promoter|transcription initiation from mitochondrial promoter|transcription initiation from mitochondrial promoter|gene expression|mitochondrial respiratory chain complex assembly|positive regulation of transcription, DNA-templated|","chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|DNA binding, bending|heat shock protein binding|poly(A) RNA binding|mitochondrial light strand promoter sense binding|",8,-3.2,2.9,9,-0.6,0.165,-1,0.951,0.485,-8.5,3.9
ENSMUSG00000057315,ARHGAP24,Rho GTPase activating protein 24,cytosol|cytoskeleton|focal adhesion|cell projection|,"angiogenesis|small GTPase mediated signal transduction|cell differentiation|activation of Rac GTPase activity|negative regulation of Rac protein signal transduction|wound healing, spreading of epidermal cells|regulation of small GTPase mediated signal transduction|negative regulation of ruffle assembly|",protein binding|Rac GTPase activator activity|,0,0,0,1,1.9,1.02,1.9,0.951,0.485,-1.6,4
ENSMUSG00000079469,PIGB,"phosphatidylinositol glycan anchor biosynthesis, class B",endoplasmic reticulum membrane|endoplasmic reticulum membrane|integral component of membrane|,C-terminal protein lipidation|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|mannosylation|,mannosyltransferase activity|,0,0,0,1,1.9,1.02,1.9,0.951,0.485,-1.6,4
ENSMUSG00000032968,INHA,"inhibin, alpha",photoreceptor outer segment|photoreceptor inner segment|extracellular region|inhibin-betaglycan-ActRII complex|neuronal cell body|inhibin A complex|,skeletal system development|ovarian follicle development|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|cell-cell signaling|nervous system development|male gonad development|response to external stimulus|cell differentiation|erythrocyte differentiation|regulation of cell proliferation|negative regulation of phosphorylation|hemoglobin biosynthetic process|negative regulation of interferon-gamma biosynthetic process|negative regulation of B cell differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|regulation of cell cycle|,receptor binding|cytokine activity|hormone activity|protein binding|protein binding|growth factor activity|inhibin binding|protein heterodimerization activity|,8,-1.6,0.0247,10,-1.3,1.03,-1.3,0.951,0.485,-6.7,6.7
ENSMUSG00000019864,RTN4IP1,reticulon 4 interacting protein 1,mitochondrion|,oxidation-reduction process|,zinc ion binding|oxidoreductase activity|,0,0,0,1,1.9,1.02,1.9,0.951,0.485,-1.6,4
ENSMUSG00000021314,AMPH,amphiphysin,synaptic vesicle|actin cytoskeleton|cell junction|synaptic vesicle membrane|leading edge membrane|,endocytosis|synaptic transmission|learning|synaptic vesicle endocytosis|,protein binding|phospholipid binding|,0,0,0,1,1.9,1.02,1.9,0.951,0.485,-1.6,4
ENSMUSG00000026187,XRCC5,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining),"nuclear telomere cap complex|nuclear chromosome, telomeric region|nucleus|nucleoplasm|cytosol|membrane|Ku70:Ku80 complex|nonhomologous end joining complex|","telomere maintenance|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|DNA recombination|transcription, DNA-templated|brain development|cell proliferation|viral process|positive regulation of type I interferon production|DNA duplex unwinding|DNA duplex unwinding|response to drug|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of neurogenesis|hematopoietic stem cell differentiation|cellular response to fatty acid|cellular hyperosmotic salinity response|cellular response to X-ray|establishment of integrated proviral latency|",DNA binding|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|protein C-terminus binding|ubiquitin protein ligase binding|telomeric DNA binding|transcription regulatory region DNA binding|poly(A) RNA binding|5'-deoxyribose-5-phosphate lyase activity|,10,-1.3,0.298,10,-1.8,0.849,-1.6,0.95,0.485,-6.5,2.1
ENSMUSG00000001034,MAPK7,mitogen-activated protein kinase 7,nucleus|nucleoplasm|cytoplasm|cytosol|cytosol|PML body|,toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|cell cycle|signal transduction|peptidyl-serine phosphorylation|cAMP-mediated signaling|cell differentiation|negative regulation of cAMP catabolic process|negative regulation of heterotypic cell-cell adhesion|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter in response to stress|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|negative regulation of inflammatory response|positive regulation of protein metabolic process|negative regulation of cyclic-nucleotide phosphodiesterase activity|stress-activated MAPK cascade|negative regulation of NFAT protein import into nucleus|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|cellular response to laminar fluid shear stress|cellular response to transforming growth factor beta stimulus|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of endothelial cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,MAP kinase activity|protein binding|ATP binding|mitogen-activated protein kinase binding|,10,-0.8,0.919,10,-0.5,0.174,-0.7,0.949,0.486,-10.5,4.2
ENSMUSG00000028776,TINAGL1,tubulointerstitial nephritis antigen-like 1,extracellular region|extracellular space|cytoplasm|extracellular matrix|extracellular vesicular exosome|,proteolysis|receptor-mediated endocytosis|immune response|endosomal transport|,scavenger receptor activity|extracellular matrix structural constituent|cysteine-type peptidase activity|polysaccharide binding|laminin binding|,1,1.6,0.908,1,0.9,0.255,1.5,0.949,0.486,-1.6,4
ENSMUSG00000036639,NUDT1,nudix (nucleoside diphosphate linked moiety X)-type motif 1,nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|extracellular vesicular exosome|,GTP catabolic process|purine nucleotide catabolic process|ATP catabolic process|dGTP catabolic process|DNA repair|response to oxidative stress|nucleobase-containing small molecule catabolic process|DNA protection|small molecule metabolic process|dATP catabolic process|nucleobase-containing small molecule metabolic process|,"GTPase activity|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|snoRNA binding|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|metal ion binding|ATP diphosphatase activity|",10,-0.3,0.0795,10,-1,1.17,-0.9,0.947,0.486,-5.7,3.7
ENSMUSG00000005447,PAFAH1B3,"platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)",cytosol|membrane|extracellular vesicular exosome|,lipid metabolic process|spermatogenesis|nervous system development|brain development|lipid catabolic process|,1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding|protein heterodimerization activity|,10,-4.4,0.816,10,-1.8,0.565,-1.8,0.947,0.486,-8.3,4.1
ENSMUSG00000013465,NELFB,negative elongation factor complex member B,nucleus|nucleoplasm|cytoplasm|NELF complex|,"transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|negative regulation of transcription, DNA-templated|positive regulation of viral transcription|",protein binding|,1,-2.5,1.02,0,0,0,-2.5,0.946,0.486,-5,1.5
ENSMUSG00000042254,CILP,"cartilage intermediate layer protein, nucleotide pyrophosphohydrolase",proteinaceous extracellular matrix|extracellular space|extracellular matrix|,negative regulation of insulin-like growth factor receptor signaling pathway|,None,1,-2.5,1.02,0,0,0,-2.5,0.946,0.486,-5,1.5
ENSMUSG00000041324,INHBA,"inhibin, beta A",extracellular region|extracellular region|activin A complex|inhibin A complex|,"G1/S transition of mitotic cell cycle|ovarian follicle development|ovarian follicle development|hair follicle development|hematopoietic progenitor cell differentiation|regulation of transcription from RNA polymerase II promoter|defense response|cell cycle arrest|cell surface receptor signaling pathway|cell-cell signaling|nervous system development|negative regulation of cell proliferation|male gonad development|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|erythrocyte differentiation|negative regulation of cell growth|positive regulation of cellular protein metabolic process|activin receptor signaling pathway|endodermal cell differentiation|growth|negative regulation of phosphorylation|odontogenesis|response to drug|hemoglobin biosynthetic process|progesterone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of B cell differentiation|positive regulation of erythrocyte differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of follicle-stimulating hormone secretion|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|mesodermal cell differentiation|palate development|positive regulation of ovulation|eyelid development in camera-type eye|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|",cytokine activity|hormone activity|protein binding|growth factor activity|peptide hormone binding|identical protein binding|protein heterodimerization activity|type II activin receptor binding|,10,1.4,1.39,10,-1.4,1.7,-1.4,0.943,0.487,-7.3,3.9
ENSMUSG00000016087,FLI1,"Fli-1 proto-oncogene, ETS transcription factor",nucleus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|hemostasis|organ morphogenesis|cell differentiation|,sequence-specific DNA binding RNA polymerase II transcription factor activity|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,-1,1.2,10,1.5,0.361,-1.1,0.94,0.487,-6,5.3
ENSMUSG00000042678,MYO15,myosin XV,cytoplasm|cytoskeleton|myosin complex|stereocilium|stereocilium bundle|cell projection|extracellular vesicular exosome|,sensory perception of sound|locomotory behavior|inner ear morphogenesis|,nucleotide binding|motor activity|actin binding|protein binding|ATP binding|,0,0,0,1,-2.4,1.01,-2.4,0.938,0.488,-4,1.6
ENSMUSG00000045969,ING1,"inhibitor of growth family, member 1",nucleus|,"protein import into nucleus|cell cycle|negative regulation of cell proliferation|regulation of cell death|chromatin modification|negative regulation of cell growth|positive regulation of transcription, DNA-templated|",protein binding|zinc ion binding|methylated histone binding|,0,0,0,1,-2.4,1.01,-2.4,0.938,0.488,-4,1.6
ENSMUSG00000038685,RTEL1,regulator of telomere elongation helicase 1,nucleus|,telomere maintenance|telomere maintenance|ATP catabolic process|DNA repair|regulation of double-strand break repair via homologous recombination|DNA duplex unwinding|DNA duplex unwinding|small molecule metabolic process|,"DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|metal ion binding|4 iron, 4 sulfur cluster binding|",10,6.1,2.92,10,-1,0.179,-1.1,0.937,0.488,-3.5,12.1
ENSMUSG00000059173,PDE1A,"phosphodiesterase 1A, calmodulin-dependent",nucleus|cytosol|neuronal cell body|,cAMP catabolic process|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|blood coagulation|fibroblast growth factor receptor signaling pathway|regulation of smooth muscle cell apoptotic process|innate immune response|cGMP catabolic process|neurotrophin TRK receptor signaling pathway|regulation of smooth muscle cell proliferation|,"3',5'-cyclic-AMP phosphodiesterase activity|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|cGMP binding|metal ion binding|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity|",10,2.2,0.985,10,0.7,0.519,1.3,0.935,0.489,-3.1,6.6
ENSMUSG00000032977,FAM207A,"family with sequence similarity 207, member A",None,None,None,1,-3.1,1.51,1,0.2,0.0129,-3,0.935,0.489,-6,1.4
ENSMUSG00000029392,RILPL1,Rab interacting lysosomal protein-like 1,nucleus|cytoplasm|centrosome|cytosol|plasma membrane|primary cilium|,epithelial cell morphogenesis|intracellular protein transport|regulation of neuron death|,None,1,-2.5,1.01,0,0,0,-2.5,0.935,0.489,-5,1.5
ENSMUSG00000022389,TEF,thyrotrophic embryonic factor,nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|",double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein homodimerization activity|sequence-specific DNA binding|protein heterodimerization activity|,10,0,0,10,-1.3,1.62,-1,0.933,0.489,-4.7,2.2
ENSMUSG00000034329,BRIP1,BRCA1 interacting protein C-terminal helicase 1,nucleus|nucleus|cytoplasm|nuclear membrane|,DNA damage checkpoint|ATP catabolic process|double-strand break repair|regulation of transcription from RNA polymerase II promoter|DNA duplex unwinding|DNA duplex unwinding|small molecule metabolic process|,"DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|metal ion binding|4 iron, 4 sulfur cluster binding|",10,-0.6,0.425,10,-1.1,0.666,-0.7,0.929,0.49,-4.1,3.4
ENSMUSG00000006345,GGT1,gamma-glutamyltransferase 1,extracellular space|plasma membrane|plasma membrane|integral component of membrane|anchored component of external side of plasma membrane|extracellular vesicular exosome|,regulation of immune system process|proteolysis|cellular amino acid metabolic process|glutamate metabolic process|leukotriene metabolic process|glutathione metabolic process|glutathione biosynthetic process|glutathione biosynthetic process|glutathione catabolic process|xenobiotic metabolic process|spermatogenesis|cysteine biosynthetic process|arachidonic acid metabolic process|leukotriene biosynthetic process|zymogen activation|small molecule metabolic process|regulation of inflammatory response|glutathione derivative biosynthetic process|,gamma-glutamyltransferase activity|gamma-glutamyltransferase activity|protein binding|glutathione hydrolase activity|,10,3.7,1.74,10,-1.3,1.02,-0.9,0.929,0.49,-7.2,8.5
ENSMUSG00000057113,NPM1,"nucleophosmin (nucleolar phosphoprotein B23, numatrin)",nucleus|nucleus|nucleoplasm|nucleoplasm|nucleolus|cytoplasm|cytoplasm|centrosome|centrosome|cytosol|membrane|ribonucleoprotein complex|spindle pole centrosome|,DNA repair|nucleosome assembly|nucleosome assembly|intracellular protein transport|nucleocytoplasmic transport|nucleocytoplasmic transport|response to stress|centrosome cycle|centrosome cycle|signal transduction|cell aging|cell aging|protein localization|negative regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of centrosome duplication|viral process|regulation of endodeoxyribonuclease activity|centromere-specific nucleosome assembly|ribosome assembly|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of translation|regulation of centriole replication|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endoribonuclease activity|regulation of eIF2 alpha phosphorylation by dsRNA|,transcription coactivator activity|RNA binding|protein kinase inhibitor activity|protein binding|protein kinase binding|Tat protein binding|histone binding|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|poly(A) RNA binding|protein heterodimerization activity|NF-kappaB binding|NF-kappaB binding|unfolded protein binding|unfolded protein binding|,8,-2,0.566,6,-1.3,0.586,-1.4,0.927,0.491,-4.5,1.3
ENSMUSG00000049734,TREX1,three prime repair exonuclease 1,nucleus|nuclear envelope|nucleolus|endoplasmic reticulum membrane|cytosol|,"DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|DNA metabolic process|DNA replication|DNA repair|mismatch repair|DNA recombination|cell death|regulation of type I interferon production|positive regulation of type I interferon production|cellular response to interferon-beta|innate immune response|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|",double-stranded DNA binding|single-stranded DNA binding|3'-5'-exodeoxyribonuclease activity|3'-5' exonuclease activity|3'-5' exonuclease activity|exodeoxyribonuclease III activity|MutLalpha complex binding|MutSalpha complex binding|adenyl deoxyribonucleotide binding|protein homodimerization activity|protein homodimerization activity|metal ion binding|metal ion binding|,10,-0.2,0.0269,10,-0.9,1.2,-0.7,0.927,0.491,-5.8,3
ENSMUSG00000053916,NANP,N-acetylneuraminic acid phosphatase,cellular_component|,carbohydrate metabolic process|N-acetylglucosamine biosynthetic process|dephosphorylation|dephosphorylation|N-acetylneuraminate biosynthetic process|,N-acylneuraminate-9-phosphatase activity|,10,-3.7,1.85,10,-0.9,1.01,-1.4,0.925,0.491,-8.6,6.7
ENSMUSG00000015542,NAT9,"N-acetyltransferase 9 (GCN5-related, putative)",protein complex|,metabolic process|,N-acetyltransferase activity|,1,-2.5,0.996,0,0,0,-2.5,0.923,0.492,-5,1.5
ENSMUSG00000024742,FEN1,flap structure-specific endonuclease 1,nucleus|nucleoplasm|nucleolus|mitochondrion|membrane|,"mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|DNA replication|DNA strand elongation involved in DNA replication|DNA repair|DNA repair|base-excision repair|double-strand break repair|memory|UV protection|telomere maintenance via semi-conservative replication|DNA replication, removal of RNA primer|phosphatidylinositol-mediated signaling|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|",magnesium ion binding|DNA binding|damaged DNA binding|double-stranded DNA binding|endonuclease activity|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|double-stranded DNA exodeoxyribonuclease activity|5'-3' exonuclease activity|5'-flap endonuclease activity|5'-flap endonuclease activity|manganese ion binding|,10,-0.8,0.695,10,-0.6,0.335,-0.7,0.923,0.492,-6.9,1.7
ENSMUSG00000069895,ATXN1L,ataxin 1-like,nucleus|dendrite|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|RNA binding|protein binding|,1,-2.5,0.996,0,0,0,-2.5,0.923,0.492,-5,1.5
ENSMUSG00000037280,GALNT6,polypeptide N-acetylgalactosaminyltransferase 6,Golgi membrane|Golgi apparatus|integral component of membrane|perinuclear region of cytoplasm|,protein O-linked glycosylation|O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,-1.8,1.29,10,0.9,0.624,-1.5,0.922,0.492,-6.8,3.7
ENSMUSG00000062380,TUBB3,"tubulin, beta 3 class III",nucleus|cytoplasm|microtubule|,GTP catabolic process|protein folding|microtubule-based process|axon guidance|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|,10,-0.7,1.39,10,0,0,-0.5,0.922,0.492,-11.4,2.7
ENSMUSG00000021238,ALDH6A1,"aldehyde dehydrogenase 6 family, member A1",nucleus|mitochondrion|mitochondrion|mitochondrial matrix|extracellular vesicular exosome|,thymine catabolic process|valine metabolic process|valine catabolic process|branched-chain amino acid catabolic process|thymine metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|brown fat cell differentiation|oxidation-reduction process|,fatty-acyl-CoA binding|methylmalonate-semialdehyde dehydrogenase (acylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity|malonate-semialdehyde dehydrogenase (acetylating) activity|poly(A) RNA binding|,10,-1.8,1.75,10,-0.2,0.0053,-1,0.92,0.492,-4.4,2.1
ENSMUSG00000024532,1700034E13RIK,RIKEN cDNA 1700034E13 gene,cellular_component|,biological_process|,molecular_function|,1,-2.2,0.813,1,-1.5,0.293,-1.9,0.92,0.492,-4,1.6
ENSMUSG00000042042,CSGALNACT2,chondroitin sulfate N-acetylgalactosaminyltransferase 2,Golgi membrane|membrane|integral component of Golgi membrane|Golgi cisterna membrane|,"carbohydrate metabolic process|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|",acetylgalactosaminyltransferase activity|metal ion binding|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|,10,-0.8,0.837,10,-0.8,0.16,-0.8,0.919,0.493,-4.2,1.7
ENSMUSG00000037815,CTNNA1,"catenin (cadherin-associated protein), alpha 1, 102kDa",acrosomal vesicle|cytosol|plasma membrane|cell-cell junction|zonula adherens|intercalated disc|actin cytoskeleton|catenin complex|lamellipodium|,ovarian follicle development|cell adhesion|establishment or maintenance of cell polarity|negative regulation of neuroblast proliferation|aging|male gonad development|gap junction assembly|axon regeneration|cell junction assembly|adherens junction organization|cellular protein localization|odontogenesis of dentin-containing tooth|muscle cell differentiation|negative regulation of apoptotic process|apical junction assembly|response to estrogen|cell-cell junction organization|positive regulation of smoothened signaling pathway|positive regulation of muscle cell differentiation|protein heterooligomerization|cellular response to indole-3-methanol|epithelial cell-cell adhesion|negative regulation of cell motility|negative regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|,structural molecule activity|protein binding|beta-catenin binding|vinculin binding|poly(A) RNA binding|gamma-catenin binding|cadherin binding|actin filament binding|,9,0.7,0.434,10,-2.4,2.53,-2.3,0.917,0.493,-7.4,3.2
ENSMUSG00000014503,PKD2L2,polycystic kidney disease 2-like 2,integral component of membrane|,biological_process|detection of mechanical stimulus|calcium ion transmembrane transport|,calcium channel activity|calcium ion binding|,0,0,0,1,1.9,0.988,1.9,0.916,0.493,-1.6,4
ENSMUSG00000026568,MPC2,mitochondrial pyruvate carrier 2,nucleus|mitochondrion|mitochondrial inner membrane|integral component of membrane|,pyruvate metabolic process|mitochondrial pyruvate transport|cellular metabolic process|small molecule metabolic process|pyruvate transmembrane transport|,pyruvate transmembrane transporter activity|,0,0,0,1,1.9,0.988,1.9,0.916,0.493,-1.6,4
ENSMUSG00000064156,PROL1,"proline rich, lacrimal 1",extracellular region|extracellular space|,retina homeostasis|negative regulation of endopeptidase activity|regulation of sensory perception of pain|,endopeptidase inhibitor activity|peptidase inhibitor activity|,0,0,0,1,1.9,0.988,1.9,0.916,0.493,-1.6,4
ENSMUSG00000028646,RRAGC,Ras-related GTP binding C,nucleus|cytoplasm|lysosome|intracellular membrane-bounded organelle|,"GTP catabolic process|transcription, DNA-templated|apoptotic process|small GTPase mediated signal transduction|RNA splicing|cell growth|cellular protein localization|cellular response to amino acid stimulus|",magnesium ion binding|GTPase activity|protein binding|GTP binding|GDP binding|protein heterodimerization activity|,0,0,0,1,1.9,0.988,1.9,0.916,0.493,-1.6,4
ENSMUSG00000034706,DNAIC2,"dynein, axonemal, intermediate chain 2",cytoplasm|cytoskeleton|axonemal dynein complex|microtubule|cilium|axoneme|dynein complex|cell projection|,metabolic process|cell projection organization|cilium assembly|,motor activity|microtubule motor activity|protein binding|,0,0,0,1,1.9,0.988,1.9,0.916,0.493,-1.6,4
ENSMUSG00000074682,ZCCHC3,"zinc finger, CCHC domain containing 3",None,None,zinc ion binding|poly(A) RNA binding|,10,-2.5,1.75,10,2.6,3.42,-0.9,0.913,0.494,-8.8,6.6
ENSMUSG00000039910,CITED2,"Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2",nuclear chromatin|nucleus|nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|response to hypoxia|response to hypoxia|trophectodermal cell differentiation|neural tube closure|liver development|embryonic placenta development|heart looping|lens morphogenesis in camera-type eye|hematopoietic progenitor cell differentiation|outflow tract morphogenesis|regulation of organ formation|endocardial cushion development|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|determination of left/right symmetry|central nervous system development|peripheral nervous system development|heart development|heart development|sex determination|cell aging|cell proliferation|male gonad development|response to mechanical stimulus|positive regulation of gene expression|negative regulation of gene expression|cranial nerve morphogenesis|positive regulation of cell-cell adhesion|negative regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|granulocyte differentiation|response to fluid shear stress|positive regulation of peroxisome proliferator activated receptor signaling pathway|adrenal cortex formation|skeletal muscle cell differentiation|negative regulation of apoptotic process|response to estrogen|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|decidualization|spleen development|thymus development|embryonic camera-type eye morphogenesis|erythrocyte development|embryonic process involved in female pregnancy|bone morphogenesis|ventricular septum morphogenesis|embryonic heart tube left/right pattern formation|pulmonary artery morphogenesis|cardiac neural crest cell development involved in heart development|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|left/right axis specification|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of male gonad development|regulation of RNA biosynthetic process|",RNA polymerase II activating transcription factor binding|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription corepressor activity|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription corepressor activity|protein binding|histone acetyltransferase binding|SMAD binding|LBD domain binding|,10,0,0,10,-2.2,1.68,-1.2,0.912,0.494,-8.3,5.3
ENSMUSG00000028608,0610037L13RIK,RIKEN cDNA 0610037L13 gene,extracellular vesicular exosome|,biological_process|,molecular_function|,0,0,0,1,-2.4,0.981,-2.4,0.909,0.495,-4,1.6
ENSMUSG00000003308,KEAP1,kelch-like ECH-associated protein 1,nucleus|cytoplasm|endoplasmic reticulum|microtubule organizing center|midbody|Cul3-RING ubiquitin ligase complex|,"in utero embryonic development|transcription, DNA-templated|regulation of transcription, DNA-templated|proteasomal ubiquitin-independent protein catabolic process|protein ubiquitination|protein ubiquitination|regulation of epidermal cell differentiation|cellular response to interleukin-4|",protein binding|,10,-1.6,0.183,10,-3.8,0.854,-0.5,0.907,0.495,-8.6,3
ENSMUSG00000020383,IL13,interleukin 13,extracellular region|extracellular space|cytoplasm|external side of plasma membrane|,positive regulation of immunoglobulin production|cellular component movement|inflammatory response|immune response|signal transduction|cell-cell signaling|regulation of proton transport|positive regulation of B cell proliferation|response to lipopolysaccharide|positive regulation of connective tissue growth factor production|response to nicotine|positive regulation of tyrosine phosphorylation of Stat6 protein|positive regulation of macrophage activation|response to ethanol|positive regulation of smooth muscle cell proliferation|positive regulation of protein secretion|positive regulation of release of sequestered calcium ion into cytosol|cellular response to mechanical stimulus|cellular response to cytokine stimulus|negative regulation of transforming growth factor beta production|negative regulation of lung ciliated cell differentiation|positive regulation of lung goblet cell differentiation|positive regulation of pancreatic stellate cell proliferation|,cytokine activity|interleukin-13 receptor binding|protein binding|,10,-0.6,0.351,10,-5.4,1.06,-0.7,0.907,0.495,-10.1,1.8
ENSMUSG00000030209,GRIN2B,"glutamate receptor, ionotropic, N-methyl D-aspartate 2B",plasma membrane|integral component of plasma membrane|synaptic vesicle|cell surface|postsynaptic density|N-methyl-D-aspartate selective glutamate receptor complex|cell junction|dendrite|neuron projection|postsynaptic membrane|,"behavioral fear response|in utero embryonic development|startle response|suckling behavior|transport|glutamate receptor signaling pathway|synaptic transmission|sensory organ development|learning or memory|learning|memory|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|response to ethanol|regulation of synaptic plasticity|behavioral response to pain|detection of mechanical stimulus involved in sensory perception of pain|regulation of excitatory postsynaptic membrane potential|calcium ion transmembrane transport|",N-methyl-D-aspartate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|calcium channel activity|protein binding|zinc ion binding|glycine binding|,10,-2,1.82,10,-0.5,0.343,-1.7,0.905,0.496,-7.3,3.7
ENSMUSG00000055322,TNS1,tensin 1,cytoplasm|cytoskeleton|focal adhesion|cell surface|,cell-substrate junction assembly|fibroblast migration|,actin binding|protein binding|poly(A) RNA binding|,10,1.4,1.1,10,0.5,0.112,0.8,0.903,0.496,-6.6,6.6
ENSMUSG00000031174,RPGR,retinitis pigmentosa GTPase regulator,photoreceptor outer segment|Golgi apparatus|centrosome|ciliary basal body|sperm flagellum|,intracellular protein transport|visual perception|intraciliary transport|cilium assembly|eye photoreceptor cell development|positive regulation of GTPase activity|response to stimulus|,guanyl-nucleotide exchange factor activity|protein binding|poly(A) RNA binding|,0,0,0,2,2.2,0.974,2.2,0.903,0.496,-3.5,5
ENSMUSG00000028212,CCNE2,cyclin E2,nucleoplasm|cytosol|,cell cycle checkpoint|regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication initiation|cell division|,protein binding|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|,10,1,1.08,10,0.3,0.0386,0.8,0.902,0.497,-3.6,4.8
ENSMUSG00000021978,EXTL3,exostosin-like glycosyltransferase 3,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|,activation of signaling protein activity involved in unfolded protein response|heparan sulfate proteoglycan biosynthetic process|positive regulation of cell growth|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|,glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|,1,-2.5,0.972,0,0,0,-2.5,0.9,0.497,-5,1.5
ENSMUSG00000026062,SLC9A2,"solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2",plasma membrane|integral component of membrane|,ion transport|regulation of pH|protein localization|sodium ion transmembrane transport|sodium ion transmembrane transport|transmembrane transport|hydrogen ion transmembrane transport|,sodium:proton antiporter activity|,1,-2.5,0.972,0,0,0,-2.5,0.9,0.497,-5,1.5
ENSMUSG00000056131,PGM3,phosphoglucomutase 3,cellular_component|cytosol|cytosol|,glucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|UDP-N-acetylglucosamine biosynthetic process|UDP-N-acetylglucosamine biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|spermatogenesis|embryo development|protein N-linked glycosylation via asparagine|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|cellular protein metabolic process|,magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity|,1,-2.5,0.972,0,0,0,-2.5,0.9,0.497,-5,1.5
ENSMUSG00000020834,DHRS13,dehydrogenase/reductase (SDR family) member 13,extracellular region|membrane|,oxidation-reduction process|,oxidoreductase activity|,1,-2.5,0.972,0,0,0,-2.5,0.9,0.497,-5,1.5
ENSMUSG00000066438,PLEKHD1,"pleckstrin homology domain containing, family D (with coiled-coil domains) member 1",None,None,None,1,-2.5,0.972,0,0,0,-2.5,0.9,0.497,-5,1.5
ENSMUSG00000060098,PRMT7,protein arginine methyltransferase 7,nucleus|nucleolus|cytosol|plasma membrane|,"spliceosomal snRNP assembly|regulation of gene expression by genetic imprinting|transcription, DNA-templated|regulation of transcription, DNA-templated|histone methylation|peptidyl-arginine methylation|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|cell differentiation|histone arginine methylation|histone arginine methylation|DNA methylation involved in gamete generation|regulation of protein binding|histone H4-R3 methylation|",histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|[myelin basic protein]-arginine N-methyltransferase activity|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|histone binding|ribonucleoprotein complex binding|histone methyltransferase activity (H4-R3 specific)|,10,-1.2,0.846,10,-0.9,0.189,-1.1,0.9,0.497,-5.5,1.5
ENSMUSG00000024505,DTWD2,DTW domain containing 2,None,None,None,0,0,0,1,1.9,0.969,1.9,0.898,0.498,-1.6,4
ENSMUSG00000040136,ABCC8,"ATP-binding cassette, sub-family C (CFTR/MRP), member 8",plasma membrane|voltage-gated potassium channel complex|,carbohydrate metabolic process|energy reserve metabolic process|ATP catabolic process|potassium ion transport|signal transduction|signal transduction|synaptic transmission|small molecule metabolic process|regulation of insulin secretion|transmembrane transport|potassium ion transmembrane transport|,"ATP binding|sulfonylurea receptor activity|potassium ion transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of substances|ion channel binding|",1,-2.4,0.959,0,0,0,-2.4,0.889,0.501,-5,1.6
ENSMUSG00000025930,MSC,musculin,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|branchiomeric skeletal muscle development|palate development|diaphragm development|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein dimerization activity|,1,-2.4,0.959,0,0,0,-2.4,0.889,0.501,-5,1.6
ENSMUSG00000030043,TACR1,tachykinin receptor 1,cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|cell surface|dendrite|cell body|,"aggressive behavior|acute inflammatory response|positive regulation of leukocyte migration|angiotensin-mediated drinking behavior|inflammatory response|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|tachykinin receptor signaling pathway|long-term memory|associative learning|response to heat|detection of abiotic stimulus|response to ozone|positive regulation of epithelial cell migration|response to auditory stimulus|regulation of smooth muscle cell migration|positive regulation of synaptic transmission, cholinergic|positive regulation of synaptic transmission, GABAergic|response to estradiol|response to progesterone|response to nicotine|operant conditioning|positive regulation of renal sodium excretion|sperm ejaculation|eating behavior|positive regulation of vascular permeability|response to morphine|response to ethanol|positive regulation of action potential|positive regulation of blood pressure|positive regulation of ossification|positive regulation of vasoconstriction|positive regulation of saliva secretion|positive regulation of hormone secretion|behavioral response to pain|regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|positive regulation of epithelial cell proliferation|positive regulation of stress fiber assembly|smooth muscle contraction involved in micturition|positive regulation of uterine smooth muscle contraction|",tachykinin receptor activity|protein binding|substance P receptor activity|,10,1.7,0.806,10,-3.7,2.83,-2.6,0.888,0.501,-8.2,3.4
ENSMUSG00000047730,FCGBP,Fc fragment of IgG binding protein,extracellular vesicular exosome|,None,protein binding|,10,-0.5,0.31,10,0.8,0.816,0.6,0.887,0.501,-3.8,4.7
ENSMUSG00000049191,RGAG4,retrotransposon gag domain containing 4,None,None,None,10,-0.4,0.214,10,-1.6,1.01,-1.5,0.886,0.501,-6.1,2.7
ENSMUSG00000039968,RSBN1L,round spermatid basic protein 1-like,nucleus|,None,None,1,1.7,0.954,0,0,0,1.7,0.884,0.502,-1.6,4
ENSMUSG00000029599,DDX54,DEAD (Asp-Glu-Ala-Asp) box polypeptide 54,nucleus|nucleolus|membrane|,"ATP catabolic process|ATP catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|RNA metabolic process|intracellular estrogen receptor signaling pathway|",transcription corepressor activity|ATP-dependent RNA helicase activity|receptor binding|ATP binding|estrogen receptor binding|poly(A) RNA binding|,9,-2.6,1.52,9,1,0.507,-2.3,0.884,0.502,-8.2,5.1
ENSMUSG00000024725,OSTF1,osteoclast stimulating factor 1,intracellular|cytoplasm|extracellular vesicular exosome|,ossification|signal transduction|,protein binding|SH3 domain binding|,1,1.7,0.954,0,0,0,1.7,0.884,0.502,-1.6,4
ENSMUSG00000068302,NOTO,notochord homeobox,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|determination of left/right symmetry|embryonic pattern specification|dorsal/ventral pattern formation|notochord development|cilium morphogenesis|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-1.7,0.666,1,-1.5,0.304,-1.6,0.881,0.503,-3,1.7
ENSMUSG00000032194,KANK2,KN motif and ankyrin repeat domains 2,cytoplasm|mitochondrion|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|apoptotic process|negative regulation of cell proliferation|negative regulation of intracellular estrogen receptor signaling pathway|negative regulation of programmed cell death|negative regulation of G1/S transition of mitotic cell cycle|",protein binding|,0,0,0,1,1.9,0.95,1.9,0.88,0.503,-1.6,4
ENSMUSG00000037933,BICD2,bicaudal D homolog 2 (Drosophila),cytoplasm|Golgi apparatus|cytoskeleton|plasma membrane|cytoplasmic vesicle|,cell death|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center|,protein binding|Rab GTPase binding|,0,0,0,1,1.9,0.95,1.9,0.88,0.503,-1.6,4
ENSMUSG00000038253,HOXA5,homeobox A5,nucleus|,"respiratory system process|transcription, DNA-templated|anterior/posterior pattern specification|positive regulation of receptor biosynthetic process|cell migration|negative regulation of angiogenesis|thyroid gland development|regulation of mammary gland epithelial cell proliferation|multicellular organism growth|positive regulation of apoptotic process|positive regulation of myeloid cell differentiation|negative regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|lung alveolus development|embryonic skeletal system morphogenesis|bronchiole development|epithelial tube branching involved in lung morphogenesis|lung goblet cell differentiation|lung-associated mesenchyme development|trachea cartilage morphogenesis|intestinal epithelial cell maturation|mesenchymal-epithelial cell signaling|mammary gland epithelial cell differentiation|mammary gland alveolus development|cell-cell signaling involved in mammary gland development|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,0,0,0,1,1.9,0.95,1.9,0.88,0.503,-1.6,4
ENSMUSG00000079055,SLC8A3,"solute carrier family 8 (sodium/calcium exchanger), member 3",mitochondrion|microtubule|plasma membrane|integral component of membrane|sarcolemma|neuronal cell body|dendritic spine|,ion transport|cell communication|blood coagulation|telencephalon development|sodium ion transmembrane transport|transmembrane transport|calcium ion transport into cytosol|cellular response to cAMP|calcium ion export from cell|calcium ion import into cell|,calcium:sodium antiporter activity|calmodulin binding|,0,0,0,1,1.9,0.95,1.9,0.88,0.503,-1.6,4
ENSMUSG00000025153,FASN,fatty acid synthase,cytoplasm|mitochondrion|Golgi apparatus|cytosol|plasma membrane|membrane|melanosome|glycogen granule|extracellular vesicular exosome|,osteoblast differentiation|acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid metabolic process|fatty acid biosynthetic process|vitamin metabolic process|water-soluble vitamin metabolic process|pantothenate metabolic process|triglyceride biosynthetic process|positive regulation of cellular metabolic process|long-chain fatty-acyl-CoA biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|cellular response to interleukin-4|,"fatty acid synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|oleoyl-[acyl-carrier-protein] hydrolase activity|protein binding|drug binding|zinc ion binding|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|protein homodimerization activity|poly(A) RNA binding|enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity|NADPH binding|",10,-0.5,0.211,10,-1.4,0.932,-1.4,0.879,0.504,-7.4,1.6
ENSMUSG00000005360,SLC1A3,"solute carrier family 1 (glial high affinity glutamate transporter), member 3",plasma membrane|cell surface|membrane|integral component of membrane|cell projection|neuronal cell body|fibril|,neurotransmitter uptake|glutamate biosynthetic process|ion transport|synaptic transmission|sensory perception of sound|response to light stimulus|gamma-aminobutyric acid biosynthetic process|response to wounding|cranial nerve development|auditory behavior|response to drug|response to antibiotic|cell morphogenesis involved in neuron differentiation|positive regulation of synaptic transmission|neuromuscular process controlling balance|L-glutamate import|transmembrane transport|D-aspartate import|,L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|glutamate binding|sodium:dicarboxylate symporter activity|,0,0,0,1,-2.3,0.949,-2.3,0.879,0.504,-4,1.6
ENSMUSG00000040562,GSTM2,glutathione S-transferase mu 2 (muscle),cytoplasm|cytosol|sarcoplasmic reticulum|extracellular vesicular exosome|,glutathione metabolic process|xenobiotic metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|nitrobenzene metabolic process|xenobiotic catabolic process|small molecule metabolic process|relaxation of cardiac muscle|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|cellular detoxification of nitrogen compound|cellular response to caffeine|glutathione derivative biosynthetic process|,glutathione transferase activity|receptor binding|enzyme binding|protein homodimerization activity|glutathione binding|,10,-2.2,1.45,10,0.6,0.31,-1.5,0.875,0.505,-5.2,2.9
ENSMUSG00000079566,SPIN2D,"spindlin family, member 2D",cellular_component|,biological_process|,molecular_function|,4,1.5,0.284,3,-4,1.75,-2.6,0.869,0.506,-8,3.3
ENSMUSG00000029576,RADIL,Ras association and DIL domains,microtubule|,signal transduction|multicellular organismal development|substrate adhesion-dependent cell spreading|,None,10,-4.8,3.52,10,0.3,0.00112,-2.7,0.869,0.506,-9.6,6.1
ENSMUSG00000033933,VHL,"von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase",nucleus|nucleoplasm|mitochondrion|endoplasmic reticulum|cytosol|membrane|intermediate filament cytoskeleton|,"negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|regulation of transcription, DNA-templated|proteolysis|response to stress|negative regulation of cell proliferation|protein ubiquitination|protein ubiquitination|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|protein stabilization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|",ubiquitin-protein transferase activity|protein binding|transcription factor binding|enzyme binding|,10,1.1,1.04,10,0.4,0.162,0.8,0.869,0.506,-5.4,5.8
ENSMUSG00000028274,RNGTT,RNA guanylyltransferase and 5'-phosphatase,nucleus|nucleoplasm|,transcription from RNA polymerase II promoter|7-methylguanosine mRNA capping|7-methylguanosine mRNA capping|RNA processing|gene expression|viral process|peptidyl-tyrosine dephosphorylation|polynucleotide 5' dephosphorylation|,mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|GTP binding|protein tyrosine/serine/threonine phosphatase activity|RNA guanylyltransferase activity|triphosphatase activity|,6,3.4,2.3,3,0,0,3.2,0.868,0.506,-6.2,7.8
ENSMUSG00000041445,MMRN2,multimerin 2,basement membrane|extracellular space|extracellular vesicular exosome|,angiogenesis|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of cell migration involved in sprouting angiogenesis|,protein binding|,1,-2.4,0.936,0,0,0,-2.4,0.867,0.507,-5,1.6
ENSMUSG00000039358,DRD5,dopamine receptor D5,plasma membrane|plasma membrane|integral component of plasma membrane|integral component of plasma membrane|brush border membrane|,"synaptic transmission, dopaminergic|response to amphetamine|regulation of systemic arterial blood pressure by vasopressin|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|cellular calcium ion homeostasis|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|synaptic transmission|associative learning|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|transmission of nerve impulse|negative regulation of NAD(P)H oxidase activity|wound healing|response to cocaine|positive regulation of adenylate cyclase activity|positive regulation of adenylate cyclase activity|negative regulation of blood pressure|regulation of female receptivity|sensitization|phospholipase C-activating dopamine receptor signaling pathway|long term synaptic depression|cellular response to catecholamine stimulus|reactive oxygen species metabolic process|","dopamine neurotransmitter receptor activity, coupled via Gs|dopamine neurotransmitter receptor activity|dopamine binding|",1,-2.4,0.936,0,0,0,-2.4,0.867,0.507,-5,1.6
ENSMUSG00000032299,COMMD4,COMM domain containing 4,cytoplasm|,None,protein binding|,10,-1.1,1.41,10,-0.2,0.0187,-0.8,0.864,0.508,-7.9,2.5
ENSMUSG00000029925,TBXAS1,thromboxane A synthase 1 (platelet),endoplasmic reticulum membrane|integral component of membrane|,icosanoid metabolic process|xenobiotic metabolic process|arachidonic acid metabolic process|cyclooxygenase pathway|small molecule metabolic process|oxidation-reduction process|,"monooxygenase activity|thromboxane-A synthase activity|iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|",10,1.6,1.74,10,-1,0.675,1.4,0.864,0.508,-5.7,4.9
ENSMUSG00000002190,CLGN,calmegin,nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,protein folding|protein complex assembly|single fertilization|binding of sperm to zona pellucida|,calcium ion binding|unfolded protein binding|,10,-0.6,0.403,10,-0.9,0.584,-0.8,0.863,0.508,-4.5,1.6
ENSMUSG00000052957,GAS1,growth arrest-specific 1,plasma membrane|integral component of membrane|anchored component of plasma membrane|,positive regulation of mesenchymal cell proliferation|cell cycle arrest|axon guidance|regulation of smoothened signaling pathway|negative regulation of protein processing|programmed cell death|cerebellum morphogenesis|dorsal/ventral neural tube patterning|negative regulation of cell growth|cellular response to vascular endothelial growth factor stimulus|outer ear morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|regulation of apoptotic process|camera-type eye development|negative regulation of apoptotic process|cell fate commitment|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|negative regulation of mitotic cell cycle|negative regulation of mitotic cell cycle|developmental growth|eye morphogenesis|embryonic cranial skeleton morphogenesis|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|palate development|regulation of ER to Golgi vesicle-mediated transport|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,protein binding|,10,-0.9,0.48,10,-1.5,0.585,-1.2,0.863,0.508,-4.9,6.2
ENSMUSG00000027314,DLL4,delta-like 4 (Drosophila),plasma membrane|integral component of membrane|,negative regulation of transcription from RNA polymerase II promoter|angiogenesis|patterning of blood vessels|blood vessel remodeling|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|pericardium morphogenesis|signal transduction|Notch signaling pathway|Notch receptor processing|visual perception|blood circulation|negative regulation of cell proliferation|negative regulation of endothelial cell migration|dorsal aorta morphogenesis|cellular response to vascular endothelial growth factor stimulus|cellular response to fibroblast growth factor stimulus|regulation of neurogenesis|ventral spinal cord interneuron fate commitment|regulation of neural retina development|Notch signaling involved in heart development|blood vessel lumenization|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of neural precursor cell proliferation|,Notch binding|calcium ion binding|,10,0.9,1.06,10,-1.7,1.23,-1.4,0.86,0.508,-5.6,3
ENSMUSG00000029605,OAS1B,2'-5' oligoadenylate synthetase 1B,endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|,immune system process|immune response|response to virus|negative regulation of viral genome replication|innate immune response|defense response to virus|,RNA binding|double-stranded RNA binding|protein binding|ATP binding|transferase activity|,10,-0.3,0.112,10,-1.1,1.1,-0.6,0.86,0.508,-10.4,2.9
ENSMUSG00000021548,CCNH,cyclin H,nucleus|nucleoplasm|holo TFIIH complex|cyclin-dependent protein kinase activating kinase holoenzyme complex|TFIIK complex|,"regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage removal|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|gene expression|viral process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|",protein binding|DNA-dependent ATPase activity|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|,10,-4.3,3.42,10,1.4,0.577,-4.2,0.859,0.509,-8.1,2.4
ENSMUSG00000003549,ERCC1,excision repair cross-complementation group 1,"nucleotide-excision repair complex|nuclear chromosome, telomeric region|nucleus|nucleoplasm|transcription factor TFIID complex|cytoplasm|","nucleotide-excision repair, DNA damage removal|pyrimidine dimer repair by nucleotide-excision repair|DNA catabolic process, endonucleolytic|replicative cell aging|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair|DNA recombination|mitotic recombination|syncytium formation|response to oxidative stress|spermatogenesis|response to nutrient|cell proliferation|male gonad development|UV protection|response to sucrose|response to X-ray|multicellular organismal aging|negative regulation of telomere maintenance|post-embryonic hemopoiesis|multicellular organism growth|isotype switching|oogenesis|embryonic organ development|chromosome organization|",single-stranded DNA endodeoxyribonuclease activity|TFIID-class transcription factor binding|damaged DNA binding|single-stranded DNA binding|protein binding|protein C-terminus binding|TBP-class protein binding|protein domain specific binding|structure-specific DNA binding|,10,0,0,10,-1.5,1.85,-1.4,0.858,0.509,-6.2,2.5
ENSMUSG00000035356,NFKBIZ,"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta",nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|inflammatory response|",None,1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000053720,VMN2R43,"vomeronasal 2, receptor 43",cellular_component|plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|biological_process|,molecular_function|signal transducer activity|G-protein coupled receptor activity|,1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000096658,VMN2R39,"vomeronasal 2, receptor 39",cellular_component|plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|biological_process|,molecular_function|signal transducer activity|G-protein coupled receptor activity|,1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000018593,SPARC,"secreted protein, acidic, cysteine-rich (osteonectin)",extracellular region|extracellular region|proteinaceous extracellular matrix|basement membrane|extracellular space|nucleus|platelet alpha granule lumen|endocytic vesicle lumen|,ossification|platelet degranulation|signal transduction|heart development|blood coagulation|response to gravity|response to lead ion|platelet activation|extracellular matrix organization|lung development|response to lipopolysaccharide|response to L-ascorbic acid|response to cytokine|regulation of cell proliferation|response to peptide hormone|response to ethanol|response to cadmium ion|inner ear development|response to glucocorticoid|response to cAMP|response to calcium ion|bone development|cellular response to growth factor stimulus|,calcium ion binding|protein binding|collagen binding|extracellular matrix binding|,1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000040520,MANEA,"mannosidase, endo-alpha",Golgi membrane|Golgi apparatus|integral component of membrane|,protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,"glycoprotein endo-alpha-1,2-mannosidase activity|",1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000015787,ABO,"ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)",extracellular region|integral component of membrane|Golgi cisterna membrane|,protein glycosylation|,glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|fucosylgalactoside 3-alpha-galactosyltransferase activity|metal ion binding|,1,-2.4,0.924,0,0,0,-2.4,0.856,0.51,-5,1.6
ENSMUSG00000049892,RASD1,"RAS, dexamethasone-induced 1",nucleus|plasma membrane|perinuclear region of cytoplasm|,"GTP catabolic process|signal transduction|G-protein coupled receptor signaling pathway|nitric oxide mediated signal transduction|small GTPase mediated signal transduction|negative regulation of transcription, DNA-templated|",GTPase activity|GTP binding|,10,0,0,10,-1.5,1.3,-1.4,0.853,0.51,-9.5,4.5
ENSMUSG00000034863,ANO8,anoctamin 8,intracellular|plasma membrane|plasma membrane|integral component of membrane|,chloride transport|ion transmembrane transport|transmembrane transport|chloride transmembrane transport|,intracellular calcium activated chloride channel activity|,0,0,0,1,-2.3,0.92,-2.3,0.852,0.511,-4,1.6
ENSMUSG00000074794,ARRDC3,arrestin domain containing 3,endosome|plasma membrane|,temperature homeostasis|negative regulation of heat generation|negative regulation of multicellular organismal metabolic process|positive regulation of ubiquitin-protein transferase activity|fat pad development|positive regulation of adrenergic receptor signaling pathway|negative regulation of locomotion involved in locomotory behavior|,protein binding|beta-3 adrenergic receptor binding|,0,0,0,1,-2.3,0.92,-2.3,0.852,0.511,-4,1.6
ENSMUSG00000030583,SIPA1L3,signal-induced proliferation-associated 1 like 3,extracellular space|,positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,0,0,0,1,-2.3,0.92,-2.3,0.852,0.511,-4,1.6
ENSMUSG00000036961,WNT8B,"wingless-type MMTV integration site family, member 8B",extracellular region|proteinaceous extracellular matrix|extracellular space|,signal transduction|gastrulation|nervous system development|positive regulation of gene expression|negative regulation of gene expression|Wnt signaling pathway|neuron differentiation|neuron differentiation|response to estradiol|response to retinoic acid|cell fate commitment|determination of dorsal identity|cellular response to retinoic acid|,frizzled binding|,8,0.7,0.66,10,-3.3,3.08,-2.9,0.852,0.511,-8.1,2.2
ENSMUSG00000049489,FAM58B,"family with sequence similarity 58, member B",cellular_component|,"regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of transcription, DNA-templated|positive regulation of MAPK cascade|positive regulation of protein kinase activity|",protein binding|protein kinase binding|protein kinase activator activity|,0,0,0,1,-2.3,0.92,-2.3,0.852,0.511,-4,1.6
ENSMUSG00000035799,TWIST1,twist family bHLH transcription factor 1,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|ossification|osteoblast differentiation|in utero embryonic development|neuron migration|neural tube closure|aortic valve morphogenesis|mitral valve morphogenesis|endocardial cushion morphogenesis|cardiac neural crest cell migration involved in outflow tract morphogenesis|transcription from RNA polymerase II promoter|muscle organ development|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of phosphatidylinositol 3-kinase signaling|regulation of bone mineralization|positive regulation of fatty acid beta-oxidation|negative regulation of tumor necrosis factor production|positive regulation of tumor necrosis factor production|negative regulation of histone phosphorylation|negative regulation of histone acetylation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|negative regulation of peroxisome proliferator activated receptor signaling pathway|outer ear morphogenesis|odontogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|negative regulation of skeletal muscle tissue development|embryonic cranial skeleton morphogenesis|positive regulation of epithelial cell proliferation|palate development|cranial suture morphogenesis|embryonic camera-type eye formation|eyelid development in camera-type eye|cellular response to growth factor stimulus|cellular response to hypoxia|positive regulation of monocyte chemotactic protein-1 production|positive regulation of cell motility|positive regulation of cell motility|negative regulation of oxidative phosphorylation uncoupler activity|positive regulation of transcription regulatory region DNA binding|negative regulation of cellular senescence|positive regulation of interleukin-6 secretion|negative regulation of double-strand break repair|cell proliferation involved in heart valve development|positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation|",sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|transcription factor binding|protein domain specific binding|protein homodimerization activity|bHLH transcription factor binding|protein heterodimerization activity|E-box binding|,10,1.5,1.07,10,-1.5,1.57,-0.9,0.85,0.511,-3.7,4
ENSMUSG00000032366,TPM1,tropomyosin 1 (alpha),stress fiber|cytosol|cytoskeleton|muscle thin filament tropomyosin|sarcomere|filamentous actin|bleb|ruffle membrane|,in utero embryonic development|positive regulation of heart rate by epinephrine|cellular component movement|muscle contraction|regulation of muscle contraction|cytoskeleton organization|regulation of heart contraction|muscle filament sliding|muscle filament sliding|negative regulation of cell migration|ruffle organization|positive regulation of ATPase activity|cellular response to reactive oxygen species|wound healing|sarcomere organization|positive regulation of cell adhesion|positive regulation of stress fiber assembly|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|,actin binding|structural constituent of cytoskeleton|cytoskeletal protein binding|structural constituent of muscle|,9,6.4,3.96,9,0,0,6.4,0.847,0.512,-2.2,14
ENSMUSG00000045288,USH1G,Usher syndrome 1G (autosomal recessive),cytosol|plasma membrane|actin cytoskeleton|,sensory perception of sound|inner ear morphogenesis|photoreceptor cell maintenance|sensory perception of light stimulus|equilibrioception|inner ear receptor cell differentiation|,protein binding|spectrin binding|protein homodimerization activity|,0,0,0,1,1.8,0.915,1.8,0.847,0.512,-1.6,4
ENSMUSG00000042380,SMIM12,small integral membrane protein 12,integral component of membrane|,None,None,1,0,0,1,2.1,1.25,2.1,0.847,0.512,-1.6,4
ENSMUSG00000022150,DAB2,"Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)",nucleolus|lysosomal membrane|plasma membrane|plasma membrane|coated pit|apical plasma membrane|clathrin coat of coated pit|clathrin-coated vesicle membrane|intracellular membrane-bounded organelle|transforming growth factor beta receptor homodimeric complex|extracellular vesicular exosome|,"cell morphogenesis involved in differentiation|in utero embryonic development|positive regulation of receptor recycling|positive regulation of protein phosphorylation|receptor-mediated endocytosis|pinocytosis|apoptotic process|activation of JUN kinase activity|endoderm development|excretion|cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|protein transport|Wnt signaling pathway|myeloid cell differentiation|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of apoptotic process|positive regulation of endocytosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|clathrin coat assembly|positive regulation of SMAD protein import into nucleus|negative regulation of androgen receptor signaling pathway|membrane organization|cellular response to transforming growth factor beta stimulus|negative regulation of canonical Wnt signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of Wnt signaling pathway, planar cell polarity pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of early endosome to late endosome transport|positive regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|","integrin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|protein C-terminus binding|AP-2 adaptor complex binding|clathrin adaptor activity|cargo receptor activity|SMAD binding|",10,0,0,10,-2.4,2.38,-1.7,0.847,0.512,-6.5,1.9
ENSMUSG00000062542,SYT9,synaptotagmin IX,integral component of membrane|cell junction|secretory granule membrane|synaptic vesicle membrane|dense core granule|,transport|positive regulation of calcium ion-dependent exocytosis|regulation of insulin secretion|,transporter activity|identical protein binding|metal ion binding|,1,-2.4,0.914,0,0,0,-2.4,0.846,0.512,-5,1.6
ENSMUSG00000059974,NTM,neurotrimin,plasma membrane|anchored component of membrane|,cell adhesion|neuron recognition|,protein binding|,1,-2.4,0.912,0,0,0,-2.4,0.845,0.512,-5,1.6
ENSMUSG00000035236,SCAI,suppressor of cancer cell invasion,nucleus|cytoplasm|integral component of membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell migration|negative regulation of Rho protein signal transduction|",transcription corepressor activity|protein binding|,1,-2.4,0.924,1,-1.2,0.187,-2.2,0.844,0.513,-5,1.5
ENSMUSG00000031922,CEP57,centrosomal protein 57kDa,nucleus|nucleus|cytoplasm|Golgi apparatus|centrosome|cytosol|microtubule|microtubule cytoskeleton|,"protein import into nucleus, translocation|G2/M transition of mitotic cell cycle|mitotic cell cycle|spermatid development|fibroblast growth factor receptor signaling pathway|microtubule anchoring|protein homooligomerization|",protein binding|microtubule binding|fibroblast growth factor binding|protein homodimerization activity|gamma-tubulin binding|,9,-2.3,0.244,10,-1.5,0.88,-1.9,0.844,0.513,-7.7,2.2
ENSMUSG00000048416,MLF1,myeloid leukemia factor 1,nucleus|nucleus|cytoplasm|,"myeloid progenitor cell differentiation|transcription, DNA-templated|cell cycle arrest|",DNA binding|protein binding|protein domain specific binding|,9,-4.6,0.952,10,1.1,0.388,1,0.842,0.513,-7.8,5.1
ENSMUSG00000097084,FOXL1,forkhead box L1,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|visceral mesoderm-endoderm interaction involved in midgut development|heart development|organ morphogenesis|regulation of Wnt signaling pathway|proteoglycan biosynthetic process|Peyer's patch morphogenesis|","DNA binding|sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding|",1,1.6,0.908,0,0,0,1.6,0.841,0.513,-1.6,4
ENSMUSG00000027695,PLD1,"phospholipase D1, phosphatidylcholine-specific",Golgi membrane|lysosomal membrane|endosome|endoplasmic reticulum membrane|Golgi apparatus|membrane|late endosome membrane|perinuclear region of cytoplasm|,phospholipid metabolic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|chemotaxis|small GTPase mediated signal transduction|Ras protein signal transduction|lipid catabolic process|small molecule metabolic process|glycerophospholipid biosynthetic process|defense response to Gram-positive bacterium|,phospholipase D activity|protein binding|phosphatidylinositol binding|N-acylphosphatidylethanolamine-specific phospholipase D activity|,10,0.7,0.602,10,0.6,0.326,0.7,0.84,0.514,-3.1,5
ENSMUSG00000024921,SMARCA2,"SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2",nuclear chromatin|nucleus|nucleoplasm|SWI/SNF complex|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|npBAF complex|nBAF complex|,"negative regulation of transcription from RNA polymerase II promoter|ATP catabolic process|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nervous system development|negative regulation of cell proliferation|negative regulation of cell growth|aortic smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II transcription coactivator activity|transcription coactivator activity|helicase activity|protein binding|ATP binding|DNA-dependent ATPase activity|histone binding|transcription regulatory region DNA binding|,10,0,0,10,1.4,1.81,0.9,0.839,0.514,-4.4,5.4
ENSMUSG00000025395,PRIM1,"primase, DNA, polypeptide 1 (49kDa)",nucleoplasm|membrane|primosome complex|,"G1/S transition of mitotic cell cycle|mitotic cell cycle|telomere maintenance via recombination|telomere maintenance|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA strand elongation involved in DNA replication|telomere maintenance via semi-conservative replication|",DNA primase activity|metal ion binding|,9,-1.8,0.167,7,1.1,0.906,0.9,0.839,0.514,-3.8,4.3
ENSMUSG00000057322,RPL38,ribosomal protein L38,cytosol|cytosolic large ribosomal subunit|eukaryotic 80S initiation complex|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|skeletal system development|ossification|translation|translation|translational initiation|translational elongation|translational termination|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|sensory perception of sound|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|90S preribosome assembly|middle ear morphogenesis|cellular protein metabolic process|axial mesoderm development|",RNA binding|structural constituent of ribosome|,6,1.7,1.26,5,-2.6,0.847,-1.7,0.839,0.514,-6.8,4.2
ENSMUSG00000062997,RPL35,ribosomal protein L35,nucleolus|cytoplasm|cytosol|membrane|cytosolic large ribosomal subunit|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation|translation|translational initiation|translational elongation|translational termination|SRP-dependent cotranslational protein targeting to membrane|gene expression|viral process|RNA metabolic process|mRNA metabolic process|viral life cycle|viral transcription|cellular protein metabolic process|",mRNA binding|structural constituent of ribosome|poly(A) RNA binding|,0,0,0,1,1.8,0.904,1.8,0.837,0.514,-1.6,4
ENSMUSG00000041915,AMMECR1L,AMMECR1-like,None,None,None,1,-2.3,0.901,0,0,0,-2.3,0.834,0.515,-5,1.6
ENSMUSG00000058368,KRTAP21-1,keratin associated protein 21-1,intermediate filament|,None,None,1,-2.3,0.901,0,0,0,-2.3,0.834,0.515,-5,1.6
ENSMUSG00000008575,NFIB,nuclear factor I/B,nucleus|nucleolus|cerebellar mossy fiber|,negative regulation of transcription from RNA polymerase II promoter|chondrocyte differentiation|DNA replication|transcription from RNA polymerase II promoter|glial cell differentiation|principal sensory nucleus of trigeminal nerve development|anterior commissure morphogenesis|hindbrain development|negative regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|Clara cell differentiation|Type I pneumocyte differentiation|Type II pneumocyte differentiation|lung ciliated cell differentiation|commissural neuron axon guidance|negative regulation of mesenchymal cell proliferation involved in lung development|negative regulation of epithelial cell proliferation involved in lung morphogenesis|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription corepressor activity|DNA binding|double-stranded DNA binding|,1,-2.3,0.901,0,0,0,-2.3,0.834,0.515,-5,1.6
ENSMUSG00000029664,TFPI2,tissue factor pathway inhibitor 2,proteinaceous extracellular matrix|nucleus|,blood coagulation|negative regulation of endopeptidase activity|,serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|,10,0,0,10,-2.9,2.27,-0.8,0.831,0.516,-10.1,3.6
ENSMUSG00000035958,TDP2,tyrosyl-DNA phosphodiesterase 2,nucleus|nucleolus|cytoplasm|PML body|intercellular bridge|,double-strand break repair|double-strand break repair|cell surface receptor signaling pathway|nucleic acid phosphodiester bond hydrolysis|regulation of RNA biosynthetic process|,magnesium ion binding|magnesium ion binding|single-stranded DNA binding|transcription corepressor activity|nuclease activity|protein binding|manganese ion binding|tyrosyl-RNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity|,10,1.4,2.73,10,-0.6,0.462,1,0.829,0.516,-3.6,4.8
ENSMUSG00000040061,PLCB2,"phospholipase C, beta 2",cytosol|,phospholipid metabolic process|activation of phospholipase C activity|synaptic transmission|lipid catabolic process|intracellular signal transduction|inositol phosphate metabolic process|small molecule metabolic process|sensory perception of bitter taste|,phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|calcium ion binding|,10,0.8,0.934,9,0.3,0.12,0.6,0.826,0.517,-3.9,4.3
ENSMUSG00000054021,SIRT5,sirtuin 5,nucleus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|cytosol|,chromatin silencing|protein deacetylation|peptidyl-lysine demalonylation|protein desuccinylation|peptidyl-lysine desuccinylation|negative regulation of reactive oxygen species metabolic process|,zinc ion binding|protein-malonyllysine demalonylase activity|protein-succinyllysine desuccinylase activity|NAD+ binding|,10,-0.2,0.057,10,-1.4,1.52,-0.7,0.825,0.517,-4.4,2.2
ENSMUSG00000035930,CHST4,carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4,trans-Golgi network|integral component of membrane|intrinsic component of Golgi membrane|,carbohydrate metabolic process|N-acetylglucosamine metabolic process|protein sulfation|sulfur compound metabolic process|cellular component movement|inflammatory response|immune response|cell adhesion|cell-cell signaling|leukocyte tethering or rolling|,N-acetylglucosamine 6-O-sulfotransferase activity|sulfotransferase activity|,0,0,0,1,-2.3,0.891,-2.3,0.825,0.517,-4,1.6
ENSMUSG00000079619,CYPT15,cysteine-rich perinuclear theca 15,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-2.3,0.891,-2.3,0.825,0.517,-4,1.6
ENSMUSG00000034152,EXOC3,exocyst complex component 3,exocyst|secretory granule membrane|,exocytosis|protein transport|cellular protein metabolic process|membrane organization|,protein binding|,1,-2.3,0.889,0,0,0,-2.3,0.823,0.518,-5,1.6
ENSMUSG00000029337,FGF5,fibroblast growth factor 5,extracellular region|extracellular space|,epidermal growth factor receptor signaling pathway|cell-cell signaling|nervous system development|cell proliferation|positive regulation of cell proliferation|positive regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|glial cell differentiation|signal transduction involved in regulation of gene expression|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell division|,fibroblast growth factor receptor binding|growth factor activity|,1,-2.3,0.889,0,0,0,-2.3,0.823,0.518,-5,1.6
ENSMUSG00000045539,SPRR3,small proline-rich protein 3,cytoplasm|extracellular vesicular exosome|,epidermis development|peptide cross-linking|keratinocyte differentiation|keratinization|wound healing|,structural molecule activity|protein binding|,1,-2.3,0.889,0,0,0,-2.3,0.823,0.518,-5,1.6
ENSMUSG00000032228,TCF12,transcription factor 12,nuclear chromatin|nucleus|transcription factor complex|cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|muscle organ development|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|enhancer binding|bHLH transcription factor binding|transcription regulatory region DNA binding|SMAD binding|protein heterodimerization activity|E-box binding|,10,-0.7,0.422,10,-0.6,0.485,-0.7,0.822,0.518,-4.5,3.6
ENSMUSG00000041415,DICER1,"dicer 1, ribonuclease type III",endoplasmic reticulum-Golgi intermediate compartment|cytosol|RISC complex|axon|dendrite|growth cone|,"negative regulation of transcription from RNA polymerase II promoter|angiogenesis|post-embryonic development|zygote asymmetric cell division|gene expression|negative regulation of Schwann cell proliferation|positive regulation of Schwann cell differentiation|stem cell maintenance|spinal cord motor neuron differentiation|nerve development|olfactory bulb interneuron differentiation|cerebral cortex development|lung development|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|pre-miRNA processing|hair follicle morphogenesis|positive regulation of myelination|peripheral nervous system myelin formation|embryonic hindlimb morphogenesis|production of miRNAs involved in gene silencing by miRNA|multicellular organism growth|regulation of viral genome replication|regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|spleen development|regulation of oligodendrocyte differentiation|branching morphogenesis of an epithelial tube|neuron projection morphogenesis|spindle assembly|defense response to virus|regulation of cell cycle|cardiac muscle cell development|inner ear receptor cell development|intestinal epithelial cell development|regulation of enamel mineralization|hair follicle cell proliferation|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|RNA phosphodiester bond hydrolysis, endonucleolytic|positive regulation of miRNA metabolic process|",double-stranded RNA binding|helicase activity|ribonuclease III activity|protein binding|ATP binding|miRNA binding|metal ion binding|,9,-3,2.4,10,-0.5,0.163,-1.1,0.82,0.519,-6.2,3
ENSMUSG00000022193,PSMB5,"proteasome (prosome, macropain) subunit, beta type, 5",proteasome complex|nucleus|nucleoplasm|cytosol|proteasome core complex|extracellular vesicular exosome|,"G1/S transition of mitotic cell cycle|protein polyubiquitination|mitotic cell cycle|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of cellular amino acid metabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|response to oxidative stress|gene expression|viral process|RNA metabolic process|mRNA metabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|negative regulation of apoptotic process|small molecule metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|",threonine-type endopeptidase activity|protein binding|,8,1.2,0.418,8,1.3,0.478,1.2,0.818,0.519,-3.4,5.3
ENSMUSG00000005892,TRH,thyrotropin-releasing hormone,extracellular region|nucleus|plasma membrane|secretory granule|,response to hypoxia|histamine metabolic process|signal transduction|cell-cell signaling|adult walking behavior|response to cold|response to glucose|hormone-mediated signaling pathway|negative regulation of glutamate secretion|positive regulation of gamma-aminobutyric acid secretion|positive regulation of insulin secretion|eating behavior|response to ethanol|response to corticosterone|negative regulation of feeding behavior|,neuropeptide hormone activity|thyrotropin-releasing hormone activity|,10,-0.9,1.24,10,0,0,-0.7,0.817,0.52,-4.5,2.3
ENSMUSG00000050357,RLTPR,"RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing",cytoplasm|membrane|,None,None,10,-0.5,0.452,10,-0.8,0.508,-0.6,0.815,0.52,-4.7,2
ENSMUSG00000040751,LAT2,"linker for activation of T cells family, member 2",plasma membrane|integral component of membrane|mast cell granule|membrane raft|extracellular vesicular exosome|,calcium-mediated signaling|intracellular signal transduction|Fc-epsilon receptor signaling pathway|B cell activation|B cell activation|mast cell degranulation|innate immune response|B cell receptor signaling pathway|,protein binding|SH2 domain binding|,0,0,0,1,1.8,0.879,1.8,0.813,0.521,-1.6,4
ENSMUSG00000040852,PLEKHH2,"pleckstrin homology domain containing, family H (with MyTH4 domain) member 2",cytoplasm|plasma membrane|lamellipodium|cortical actin cytoskeleton|,negative regulation of actin filament depolymerization|,actin binding|identical protein binding|,0,0,0,1,1.8,0.879,1.8,0.813,0.521,-1.6,4
ENSMUSG00000072573,GM10369,predicted gene 10369,cellular_component|,biological_process|,molecular_function|,1,-2.3,0.878,0,0,0,-2.3,0.813,0.521,-5,1.6
ENSMUSG00000014547,WDFY2,WD repeat and FYVE domain containing 2,None,None,metal ion binding|,1,-2.3,0.878,0,0,0,-2.3,0.813,0.521,-5,1.6
ENSMUSG00000054894,ATP5S,"ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)","mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)|",ATP biosynthetic process|proton transport|hydrogen ion transmembrane transport|,hydrogen ion transmembrane transporter activity|metal ion binding|,0,0,0,1,1.8,0.879,1.8,0.813,0.521,-1.6,4
ENSMUSG00000042271,NXT2,nuclear transport factor 2-like export factor 2,nucleus|cytoplasm|,protein transport|mRNA transport|,None,1,-2.3,0.878,0,0,0,-2.3,0.813,0.521,-5,1.6
ENSMUSG00000033618,MAP3K13,mitogen-activated protein kinase kinase kinase 13,IkappaB kinase complex|membrane|,activation of MAPKK activity|protein phosphorylation|JNK cascade|protein autophosphorylation|positive regulation of NF-kappaB transcription factor activity|,protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|protein kinase binding|identical protein binding|protein homodimerization activity|metal ion binding|,1,-2.3,0.878,0,0,0,-2.3,0.813,0.521,-5,1.6
ENSMUSG00000025010,CCNJ,cyclin J,nucleus|,None,None,10,3.9,1.04,10,0.8,0.388,0.9,0.807,0.523,-3.3,7.6
ENSMUSG00000018486,WNT9B,"wingless-type MMTV integration site family, member 9B",extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|,"branching involved in ureteric bud morphogenesis|in utero embryonic development|regulation of protein phosphorylation|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|cell-cell signaling|multicellular organismal development|regulation of asymmetric cell division|Wnt signaling pathway|neuron differentiation|neuron differentiation|male genitalia development|response to retinoic acid|regulation of tube size|positive regulation of catalytic activity|cell fate commitment|embryonic cranial skeleton morphogenesis|palate development|Wnt signaling pathway, planar cell polarity pathway|uterus morphogenesis|cornea development in camera-type eye|cellular response to retinoic acid|kidney rudiment formation|collecting duct development|establishment of planar polarity involved in nephron morphogenesis|metanephric tubule development|mesonephric duct formation|",frizzled binding|,10,-2.8,3.07,10,0.8,0.28,-2.4,0.806,0.523,-6,2.6
ENSMUSG00000020674,PXDN,peroxidasin homolog (Drosophila),proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum|extracellular matrix|,negative regulation of cytokine-mediated signaling pathway|immune response|extracellular matrix organization|hydrogen peroxide catabolic process|oxidation-reduction process|,peroxidase activity|interleukin-1 receptor antagonist activity|extracellular matrix structural constituent|heme binding|metal ion binding|,10,0.9,0.729,10,0.7,0.161,0.8,0.805,0.523,-1.7,4.4
ENSMUSG00000052516,ROBO2,"roundabout, axon guidance receptor, homolog 2 (Drosophila)",cell surface|integral component of membrane|axolemma|extracellular vesicular exosome|,metanephros development|ureteric bud development|homophilic cell adhesion|axon guidance|axon guidance|central nervous system development|brain development|axon midline choice point recognition|olfactory bulb interneuron development|retinal ganglion cell axon guidance|cellular response to hormone stimulus|positive regulation of axonogenesis|negative regulation of negative chemotaxis|negative regulation of synapse assembly|apoptotic process involved in luteolysis|,protein binding|axon guidance receptor activity|axon guidance receptor activity|identical protein binding|protein heterodimerization activity|,10,-0.2,0.0941,10,-1,1.09,-0.9,0.804,0.524,-7.7,2.7
ENSMUSG00000037358,4930578C19RIK,RIKEN cDNA 4930578C19 gene,cellular_component|extracellular region|,biological_process|,molecular_function|,10,-3.5,2.07,10,0,0,-3.4,0.804,0.524,-9.2,2.1
ENSMUSG00000036867,SMAD6,SMAD family member 6,nucleus|transcription factor complex|cytoplasm|cytosol|protein complex|,"ureteric bud development|transcription, DNA-templated|immune response|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis|negative regulation of cell proliferation|negative regulation of SMAD protein complex assembly|BMP signaling pathway|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|cell-substrate adhesion|response to laminar fluid shear stress|intracellular signal transduction|intracellular signal transduction|negative regulation of apoptotic process|response to estrogen|fat cell differentiation|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|","chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|ubiquitin protein ligase binding|type I transforming growth factor beta receptor binding|transcription regulatory region DNA binding|metal ion binding|co-SMAD binding|I-SMAD binding|R-SMAD binding|type I activin receptor binding|",9,-2.8,1.05,9,1,0.435,1.9,0.804,0.524,-8.3,6
ENSMUSG00000022412,MIEF1,mitochondrial elongation factor 1,mitochondrion|mitochondrial outer membrane|integral component of membrane|,mitochondrial fission|positive regulation of mitochondrial fission|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane|,protein binding|GDP binding|identical protein binding|ADP binding|,0,0,0,2,1.2,0.869,1.2,0.804,0.524,-1.7,3
ENSMUSG00000031434,MORC4,MORC family CW-type zinc finger 4,nucleus|,None,protein binding|ATP binding|zinc ion binding|,1,-1.9,0.714,1,2.1,1.22,2,0.803,0.524,-3.5,4
ENSMUSG00000007891,CTSD,cathepsin D,extracellular region|extracellular region|extracellular space|extracellular space|mitochondrion|lysosome|extracellular matrix|melanosome|lysosomal lumen|extracellular vesicular exosome|,autophagic vacuole assembly|proteolysis|cell death|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|,aspartic-type endopeptidase activity|protein binding|,10,-0.8,0.371,10,-3.5,1.76,-1.8,0.803,0.524,-8.8,2.7
ENSMUSG00000028850,GPATCH3,G patch domain containing 3,None,biological_process|,nucleic acid binding|,1,-2.3,0.867,0,0,0,-2.3,0.802,0.524,-5,1.6
ENSMUSG00000027478,DNMT3B,DNA (cytosine-5-)-methyltransferase 3 beta,nucleus|nuclear heterochromatin|cytoplasm|intracellular membrane-bounded organelle|,negative regulation of transcription from RNA polymerase II promoter|DNA methylation|DNA methylation|methylation-dependent chromatin silencing|regulation of gene expression by genetic imprinting|response to ionizing radiation|DNA methylation on cytosine within a CG sequence|positive regulation of gene expression|protein complex localization|response to drug|positive regulation of neuron differentiation|S-adenosylhomocysteine metabolic process|S-adenosylmethioninamine metabolic process|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|cellular response to amino acid stimulus|C-5 methylation of cytosine|,"transcription corepressor activity|transcription corepressor activity|DNA (cytosine-5-)-methyltransferase activity|DNA (cytosine-5-)-methyltransferase activity|DNA (cytosine-5-)-methyltransferase activity|protein binding|DNA-methyltransferase activity|unmethylated CpG binding|metal ion binding|DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates|",10,-1.1,1.49,10,0,0,-0.8,0.801,0.525,-5.2,1.7
ENSMUSG00000020941,MAP3K14,mitogen-activated protein kinase kinase kinase 14,cytosol|,MAPK cascade|activation of MAPKK activity|protein phosphorylation|immune response|I-kappaB kinase/NF-kappaB signaling|T cell costimulation|NIK/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|cellular response to mechanical stimulus|,protein kinase activity|NF-kappaB-inducing kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|,1,1.6,0.864,0,0,0,1.6,0.799,0.526,-1.6,4
ENSMUSG00000030816,RNF40,"ring finger protein 40, E3 ubiquitin protein ligase",ubiquitin ligase complex|nucleus|membrane|HULC complex|neuron projection|,ubiquitin-dependent protein catabolic process|histone monoubiquitination|histone H2B ubiquitination|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|syntaxin-1 binding|ubiquitin protein ligase binding|protein complex binding|protein homodimerization activity|,0,0,0,1,-2.3,0.864,-2.3,0.799,0.526,-4,1.6
ENSMUSG00000032292,NR2E3,"nuclear receptor subfamily 2, group E, member 3",nucleus|nucleoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|signal transduction|visual perception|phototransduction|gene expression|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|",steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|,10,2.6,2.53,10,-1.5,0.315,-1.5,0.796,0.527,-8.2,6.2
ENSMUSG00000052525,SPDYA,speedy/RINGO cell cycle regulator family member A,nucleus|,G1/S transition of mitotic cell cycle|cellular response to DNA damage stimulus|male meiosis|multicellular organismal development|positive regulation of cell proliferation|positive regulation of cyclin-dependent protein serine/threonine kinase activity|,protein kinase binding|,10,0.8,1.17,10,0.2,0.0364,0.6,0.796,0.527,-2.3,3.8
ENSMUSG00000014725,ADAM28,ADAM metallopeptidase domain 28,extracellular region|plasma membrane|integral component of membrane|,proteolysis|spermatogenesis|,metalloendopeptidase activity|metallopeptidase activity|zinc ion binding|,10,0.6,0.294,10,3,1.86,0.8,0.795,0.527,-6.7,7
ENSMUSG00000000346,DAZAP2,DAZ associated protein 2,nucleus|cytoplasm|,None,protein binding|WW domain binding|,10,-0.8,1.03,10,0.4,0.119,-0.6,0.795,0.527,-7.6,2
ENSMUSG00000063229,LDHA,lactate dehydrogenase A,nucleus|mitochondrion|cytosol|cilium|membrane|extracellular vesicular exosome|,pyruvate metabolic process|glycolytic process|substantia nigra development|cellular response to extracellular stimulus|cellular metabolic process|cellular carbohydrate metabolic process|small molecule metabolic process|oxidation-reduction process|,L-lactate dehydrogenase activity|protein binding|,10,0.1,0.0229,10,-0.9,1.55,-0.8,0.792,0.528,-6.4,2.6
ENSMUSG00000053768,CHCHD3,coiled-coil-helix-coiled-coil-helix domain containing 3,nucleus|cytoplasm|mitochondrion|mitochondrion|mitochondrial inner membrane|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|inner mitochondrial membrane organization|mitochondrial fusion|",RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|protein binding|phosphatase binding|protein complex scaffold|,0,0,0,1,-2.3,0.855,-2.3,0.791,0.528,-4,1.6
ENSMUSG00000031574,STAR,steroidogenic acute regulatory protein,mitochondrial intermembrane space|cytosol|mitochondrial crista|neuron projection|neuronal cell body|,"steroid biosynthetic process|bile acid biosynthetic process|C21-steroid hormone biosynthetic process|progesterone biosynthetic process|estrogen biosynthetic process|brain development|response to nutrient|steroid metabolic process|cholesterol metabolic process|glucocorticoid metabolic process|male gonad development|response to herbicide|response to ionizing radiation|response to lead ion|positive regulation of gene expression|response to activity|diterpenoid metabolic process|insecticide metabolic process|biphenyl metabolic process|dibenzo-p-dioxin metabolic process|phenol-containing compound metabolic process|phthalate metabolic process|intracellular cholesterol transport|cellular response to insulin stimulus|response to nicotine|cellular response to interferon-alpha|response to drug|response to hydrogen peroxide|circadian sleep/wake cycle, REM sleep|negative regulation of neuron apoptotic process|response to estrogen|small molecule metabolic process|response to leptin|cellular response to fibroblast growth factor stimulus|response to ethanol|regulation of neuronal synaptic plasticity|fractalkine metabolic process|positive regulation of neurogenesis|regulation of steroid biosynthetic process|response to corticosterone|response to fungicide|testosterone biosynthetic process|cellular response to lipopolysaccharide|cellular response to antibiotic|cellular response to cadmium ion|cellular response to alkaloid|cellular response to cAMP|cellular response to glucose stimulus|cellular response to interferon-gamma|cellular response to follicle-stimulating hormone stimulus|cellular response to luteinizing hormone stimulus|cellular response to growth hormone stimulus|cellular response to dexamethasone stimulus|cellular response to transforming growth factor beta stimulus|cellular response to epinephrine stimulus|",cholesterol binding|cholesterol transporter activity|,1,-2.3,0.856,0,0,0,-2.3,0.791,0.528,-5,1.6
ENSMUSG00000030103,BHLHE40,"basic helix-loop-helix family, member e40",nucleus|nucleus|nucleolus|Golgi apparatus|,"negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|circadian regulation of gene expression|entrainment of circadian clock by photoperiod|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-templated|",sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|protein domain specific binding|protein homodimerization activity|bHLH transcription factor binding|MRF binding|protein heterodimerization activity|E-box binding|,1,-2.3,0.856,0,0,0,-2.3,0.791,0.528,-5,1.6
ENSMUSG00000027834,SERPINI1,"serpin peptidase inhibitor, clade I (neuroserpin), member 1",extracellular space|extracellular vesicular exosome|,central nervous system development|peripheral nervous system development|cell death|negative regulation of endopeptidase activity|regulation of cell adhesion|regulation of proteolysis|,serine-type endopeptidase inhibitor activity|,1,-2.3,0.856,0,0,0,-2.3,0.791,0.528,-5,1.6
ENSMUSG00000068115,NINL,ninein-like,microtubule organizing center|cytosol|microtubule|,G2/M transition of mitotic cell cycle|mitotic cell cycle|,calcium ion binding|,10,-2.8,2.73,10,0.6,0.0974,-1,0.789,0.529,-8.1,3
ENSMUSG00000021286,ZFYVE21,"zinc finger, FYVE domain containing 21",endosome|focal adhesion|cytoplasmic membrane-bounded vesicle|,None,metal ion binding|,0,0,0,3,-1.6,0.853,-1.6,0.788,0.529,-3,1.6
ENSMUSG00000027905,DDX20,DEAD (Asp-Glu-Ala-Asp) box polypeptide 20,nucleus|nucleoplasm|cytoplasm|cytosol|cytosol|cytoskeleton|membrane|transcriptional repressor complex|SMN complex|SMN-Sm protein complex|Gemini of coiled bodies|,negative regulation of transcription from RNA polymerase II promoter|spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|spliceosomal snRNP assembly|ATP catabolic process|ATP catabolic process|RNA processing|gene expression|RNA metabolic process|ncRNA metabolic process|positive regulation of apoptotic process|positive regulation of apoptotic process|oogenesis|regulation of steroid biosynthetic process|,DNA binding|ATP-dependent RNA helicase activity|protein binding|ATP binding|protein domain specific binding|,5,-2.5,1.23,5,1.6,1.04,1.4,0.786,0.529,-4.7,4
ENSMUSG00000029646,CDX2,caudal type homeobox 2,condensed nuclear chromosome|nucleus|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|blood vessel development|trophectodermal cell differentiation|transcription from RNA polymerase II promoter|positive regulation of cell proliferation|endosome to lysosome transport|organ morphogenesis|anterior/posterior pattern specification|somatic stem cell maintenance|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|labyrinthine layer development|",transcription regulatory region sequence-specific DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|,10,-3.4,1.65,10,-0.9,0.467,-1.3,0.784,0.53,-9.5,2.8
ENSMUSG00000027080,MED19,mediator complex subunit 19,nucleus|mediator complex|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|,RNA polymerase II transcription cofactor activity|,0,0,0,1,-2.3,0.848,-2.3,0.784,0.53,-4,1.6
ENSMUSG00000049728,ZFP668,zinc finger protein 668,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",nucleic acid binding|DNA binding|metal ion binding|,9,-2,1.1,10,-0.6,0.413,-1.4,0.783,0.53,-4.7,2
ENSMUSG00000031229,ATRX,alpha thalassemia/mental retardation syndrome X-linked,nucleus|nuclear heterochromatin|nucleolus|cytoplasm|mitochondrion|PML body|telomeric heterochromatin|SWI/SNF superfamily-type complex|,"ATP catabolic process|DNA repair|DNA methylation|DNA recombination|nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of nuclear cell cycle DNA replication|DNA damage response, signal transduction by p53 class mediator|forebrain development|replication fork processing|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of transcription from RNA polymerase II promoter|cellular response to hydroxyurea|negative regulation of telomeric RNA transcription from RNA pol II promoter|",DNA binding|DNA helicase activity|chromatin binding|helicase activity|protein binding|ATP binding|zinc ion binding|DNA translocase activity|methylated histone binding|histone binding|chromo shadow domain binding|,10,-0.7,0.578,10,-0.7,0.274,-0.7,0.782,0.531,-3,2
ENSMUSG00000028967,ERRFI1,ERBB receptor feedback inhibitor 1,nucleus|cytoplasm|cytoplasm|extrinsic component of cytoplasmic side of plasma membrane|,response to stress|negative regulation of epidermal growth factor-activated receptor activity|negative regulation of epidermal growth factor-activated receptor activity|negative regulation of protein autophosphorylation|positive regulation of Rho GTPase activity|skin morphogenesis|regulation of keratinocyte differentiation|lung alveolus development|lung vasculature development|lung epithelium development|,Rho GTPase activator activity|protein binding|protein kinase binding|,10,0.6,0.371,8,0.8,0.505,0.8,0.782,0.531,-6.3,4
ENSMUSG00000050555,HYLS1,hydrolethalus syndrome 1,nucleus|cytoplasm|centrosome|plasma membrane|,None,None,1,-2.4,0.924,1,-1,0.148,-2.2,0.781,0.531,-5,1.5
ENSMUSG00000055980,IRS1,insulin receptor substrate 1,nucleus|cytoplasm|cytosol|plasma membrane|insulin receptor complex|caveola|intracellular membrane-bounded organelle|,positive regulation of mesenchymal cell proliferation|signal transduction|epidermal growth factor receptor signaling pathway|positive regulation of cell proliferation|insulin receptor signaling pathway|insulin receptor signaling pathway|insulin receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|regulation of gene expression|positive regulation of glucose metabolic process|phosphatidylinositol 3-kinase signaling|lipid catabolic process|positive regulation of cell migration|mammary gland development|positive regulation of fatty acid beta-oxidation|response to insulin|cellular response to insulin stimulus|protein localization to nucleus|Fc-epsilon receptor signaling pathway|glucose homeostasis|response to peptide hormone|protein kinase B signaling|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|positive regulation of glycogen biosynthetic process|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|insulin-like growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|JAK-STAT cascade involved in growth hormone signaling pathway|positive regulation of glucose import in response to insulin stimulus|,signal transducer activity|transmembrane receptor protein tyrosine kinase adaptor activity|protein kinase C binding|insulin receptor binding|insulin-like growth factor receptor binding|protein binding|SH2 domain binding|phosphatidylinositol 3-kinase binding|phosphatidylinositol 3-kinase binding|,10,0.1,0.00731,10,-0.8,1.2,-0.7,0.781,0.531,-5.6,2.8
ENSMUSG00000063694,CYCS,"cytochrome c, somatic",protein phosphatase type 2A complex|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|cytosol|respiratory chain|,apoptotic DNA fragmentation|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|dephosphorylation|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|cellular respiration|intrinsic apoptotic signaling pathway|,"protein serine/threonine phosphatase activity|iron ion binding|protein binding|heme binding|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|",3,2.3,1.4,6,-1.5,0.837,-1.4,0.78,0.532,-5.9,4.7
ENSMUSG00000031161,HDAC6,histone deacetylase 6,histone deacetylase complex|nucleus|cytoplasm|cytosol|microtubule|microtubule associated complex|cytoplasmic microtubule|caveola|inclusion body|aggresome|dynein complex|axon|dendrite|cell leading edge|perikaryon|perinuclear region of cytoplasm|,"protein polyubiquitination|transcription, DNA-templated|protein deacetylation|misfolded or incompletely synthesized protein catabolic process|intracellular protein transport|negative regulation of microtubule depolymerization|response to toxic substance|positive regulation of signal transduction|response to organic substance|regulation of receptor activity|positive regulation of epithelial cell migration|negative regulation of hydrogen peroxide metabolic process|positive regulation of receptor biosynthetic process|macroautophagy|histone deacetylation|histone deacetylation|lysosome localization|peptidyl-lysine deacetylation|cellular response to topologically incorrect protein|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein complex disassembly|negative regulation of protein complex disassembly|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|negative regulation of oxidoreductase activity|response to misfolded protein|regulation of microtubule-based movement|regulation of androgen receptor signaling pathway|regulation of establishment of protein localization|cellular response to hydrogen peroxide|aggresome assembly|polyubiquitinated misfolded protein transport|Hsp90 deacetylation|response to growth factor|histone H3 deacetylation|histone H4 deacetylation|cellular response to misfolded protein|positive regulation of chaperone-mediated protein complex assembly|tubulin deacetylation|tubulin deacetylation|positive regulation of hydrogen peroxide-mediated programmed cell death|",actin binding|histone deacetylase activity|protein binding|beta-catenin binding|microtubule binding|microtubule binding|zinc ion binding|enzyme binding|polyubiquitin binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|histone deacetylase binding|tubulin deacetylase activity|tubulin deacetylase activity|alpha-tubulin binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|tau protein binding|beta-tubulin binding|Hsp90 protein binding|dynein complex binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,2.4,1.75,10,-0.7,0.141,-0.8,0.78,0.532,-6.8,5.7
ENSMUSG00000032643,FHL3,four and a half LIM domains 3,stress fiber|nucleus|Z disc|,muscle organ development|actin cytoskeleton organization|,actin binding|zinc ion binding|,0,0,0,1,1.7,0.843,1.7,0.779,0.532,-1.6,4
ENSMUSG00000039987,PHTF2,putative homeodomain transcription factor 2,nucleus|endoplasmic reticulum|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|,0,0,0,1,1.7,0.843,1.7,0.779,0.532,-1.6,4
ENSMUSG00000000811,TXNRD3,thioredoxin reductase 3,nucleus|endoplasmic reticulum|,multicellular organismal development|spermatogenesis|cell differentiation|cell redox homeostasis|oxidation-reduction process|,thioredoxin-disulfide reductase activity|electron carrier activity|protein disulfide oxidoreductase activity|flavin adenine dinucleotide binding|NADP binding|,0,0,0,1,1.7,0.843,1.7,0.779,0.532,-1.6,4
ENSMUSG00000053253,NDFIP2,Nedd4 family interacting protein 2,Golgi membrane|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|integral component of membrane|multivesicular body membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,signal transduction|negative regulation of gene expression|positive regulation of protein ubiquitination|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of protein transport|,signal transducer activity|protein binding|WW domain binding|,0,0,0,1,1.7,0.843,1.7,0.779,0.532,-1.6,4
ENSMUSG00000061589,DOT1L,DOT1-like histone H3K79 methyltransferase,nucleus|,histone lysine methylation|histone lysine methylation|regulation of JAK-STAT cascade|regulation of transcription regulatory region DNA binding|,DNA binding|protein binding|transcription factor binding|histone-lysine N-methyltransferase activity|,10,-1.8,0.0736,10,1.7,1.45,0.8,0.776,0.533,-5.1,4.6
ENSMUSG00000036206,SH3BP4,SH3-domain binding protein 4,nucleus|cytoplasm|coated pit|clathrin-coated vesicle|extracellular vesicular exosome|,endocytosis|negative regulation of cell proliferation|positive regulation of autophagy|negative regulation of cell growth|negative regulation of TOR signaling|negative regulation of GTPase activity|regulation of catalytic activity|protein localization to lysosome|cellular response to amino acid stimulus|,GDP-dissociation inhibitor activity|protein binding|Ras GTPase binding|identical protein binding|,10,1,0.452,10,-2.2,2.82,-1.6,0.775,0.533,-6,2.5
ENSMUSG00000041650,PCCA,"propionyl CoA carboxylase, alpha polypeptide",mitochondrial matrix|cytosol|,fatty acid beta-oxidation|vitamin metabolic process|water-soluble vitamin metabolic process|biotin metabolic process|short-chain fatty acid catabolic process|cellular lipid metabolic process|small molecule metabolic process|,biotin carboxylase activity|propionyl-CoA carboxylase activity|ATP binding|biotin binding|enzyme binding|metal ion binding|,10,-0.6,0.785,10,-0.4,0.101,-0.6,0.775,0.533,-4.2,2.5
ENSMUSG00000021013,TTC8,tetratricopeptide repeat domain 8,cytoplasm|centrosome|cilium|photoreceptor connecting cilium|BBSome|ciliary basal body|ciliary membrane|,axon guidance|sensory perception of smell|protein transport|olfactory bulb development|regulation of protein localization|nonmotile primary cilium assembly|multicellular organism growth|cilium assembly|fat cell differentiation|establishment of anatomical structure orientation|sensory processing|camera-type eye photoreceptor cell differentiation|renal tubule development|,RNA polymerase II repressing transcription factor binding|protein binding|,10,-2.7,2.3,10,-0.2,0.042,-2.4,0.774,0.533,-7.1,2.8
ENSMUSG00000004668,ABCA13,"ATP-binding cassette, sub-family A (ABC1), member 13",integral component of membrane|,ATP catabolic process|transport|,ATP binding|ATPase activity|,10,4.8,2.01,10,-0.9,0.505,0.5,0.773,0.534,-3.5,9.9
ENSMUSG00000068882,SSB,Sjogren syndrome antigen B (autoantigen La),nucleus|ribonucleoprotein complex|,tRNA modification|histone mRNA metabolic process|,tRNA binding|nucleotide binding|mRNA binding|protein binding|poly(A) RNA binding|,1,-2.2,0.834,0,0,0,-2.2,0.771,0.534,-4,1.6
ENSMUSG00000025193,CUTC,cutC copper transporter,nucleus|nucleolus|cytoplasm|,copper ion transport|protein tetramerization|copper ion homeostasis|,copper ion binding|copper ion binding|,1,-2.2,0.834,0,0,0,-2.2,0.771,0.534,-4,1.6
ENSMUSG00000047749,ZC3HAV1L,"zinc finger CCCH-type, antiviral 1-like",None,None,None,0,0,0,1,-2.3,0.834,-2.3,0.771,0.534,-4,1.6
ENSMUSG00000027843,PTPN22,"protein tyrosine phosphatase, non-receptor type 22 (lymphoid)",nucleus|cytoplasm|cytoplasm|cytoplasmic side of plasma membrane|perinuclear region of cytoplasm|,protein dephosphorylation|protein dephosphorylation|T cell differentiation|regulation of natural killer cell proliferation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|phosphoanandamide dephosphorylation|regulation of innate immune response|regulation of B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|,protein tyrosine phosphatase activity|protein binding|SH3 domain binding|kinase binding|,1,-2.2,0.834,0,0,0,-2.2,0.771,0.534,-4,1.6
ENSMUSG00000068079,TCF15,transcription factor 15 (basic helix-loop-helix),nucleus|,"somitogenesis|respiratory system process|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mesoderm development|death|post-anal tail morphogenesis|eating behavior|ear development|skin development|paraxial mesoderm development|muscle organ morphogenesis|skeletal system morphogenesis|neuromuscular process controlling posture|",DNA binding|sequence-specific DNA binding transcription factor activity|protein dimerization activity|,10,-5.9,1.72,10,-0.4,0.336,-0.6,0.77,0.534,-10.8,1.8
ENSMUSG00000032192,GNB5,"guanine nucleotide binding protein (G protein), beta 5",nucleus|plasma membrane|,"GTP catabolic process|signal transduction|phototransduction, visible light|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|negative regulation of voltage-gated calcium channel activity|",GTPase activity|signal transducer activity|protein binding|G-protein gamma-subunit binding|chaperone binding|,10,-4.3,0.496,10,0.8,1.14,0.7,0.77,0.534,-7.4,5.2
ENSMUSG00000033253,SZT2,seizure threshold 2 homolog (mouse),peroxisome|extracellular vesicular exosome|,central nervous system development|embryo development|post-embryonic development|corpus callosum morphogenesis|pigmentation|regulation of superoxide dismutase activity|,molecular_function|,10,-1.7,1.41,10,0,0,1.2,0.769,0.535,-6.1,5.8
ENSMUSG00000028329,XPA,"xeroderma pigmentosum, complementation group A",nucleus|nucleoplasm|DNA replication factor A complex|cytoplasm|Golgi apparatus|intercellular bridge|,"nucleotide-excision repair, DNA damage removal|DNA repair|nucleotide-excision repair|response to oxidative stress|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|response to toxic substance|multicellular organism growth|",damaged DNA binding|protein binding|protein domain specific binding|protein homodimerization activity|metal ion binding|,10,-0.7,0.667,10,-0.6,0.173,-0.6,0.768,0.535,-3.7,1.7
ENSMUSG00000032440,TGFBR2,"transforming growth factor, beta receptor II (70/80kDa)",cytosol|plasma membrane|caveola|external side of plasma membrane|integral component of membrane|receptor complex|transforming growth factor beta receptor homodimeric complex|,blood vessel development|patterning of blood vessels|vasculogenesis|in utero embryonic development|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of tolerance induction to self antigen|positive regulation of B cell tolerance induction|positive regulation of T cell tolerance induction|protein phosphorylation|receptor-mediated endocytosis|apoptotic process|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|smoothened signaling pathway|gastrulation|brain development|heart development|embryo implantation|aging|response to nutrient|positive regulation of cell proliferation|response to mechanical stimulus|response to glucose|positive regulation of epithelial cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|signal transduction by phosphorylation|negative regulation of transforming growth factor beta receptor signaling pathway|organ regeneration|activation of protein kinase activity|embryonic hemopoiesis|wound healing|regulation of cell proliferation|response to drug|myeloid dendritic cell differentiation|positive regulation of skeletal muscle tissue regeneration|response to estrogen|digestive tract development|positive regulation of smooth muscle cell proliferation|embryonic cranial skeleton morphogenesis|positive regulation of NK T cell differentiation|cartilage development|palate development|negative regulation of cardiac muscle cell proliferation|pathway-restricted SMAD protein phosphorylation|bronchus morphogenesis|trachea formation|mammary gland morphogenesis|lung lobe morphogenesis|response to cholesterol|lens fiber cell apoptotic process|positive regulation of reactive oxygen species metabolic process|,"transmembrane receptor protein serine/threonine kinase activity|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type II|protein binding|protein binding|ATP binding|glycosaminoglycan binding|mitogen-activated protein kinase kinase kinase binding|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding|SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta binding|",10,1.1,0.811,10,0.5,0.143,0.9,0.767,0.536,-2.7,4.8
ENSMUSG00000024924,VLDLR,very low density lipoprotein receptor,plasma membrane|coated pit|membrane|integral component of membrane|very-low-density lipoprotein particle|receptor complex|,negative regulation of transcription from RNA polymerase II promoter|lipid transport|receptor-mediated endocytosis|signal transduction|nervous system development|memory|cholesterol metabolic process|ventral spinal cord development|glycoprotein transport|very-low-density lipoprotein particle clearance|reelin-mediated signaling pathway|positive regulation of protein kinase activity|positive regulation of dendrite development|,glycoprotein binding|low-density lipoprotein receptor activity|calcium ion binding|protein binding|very-low-density lipoprotein particle receptor activity|apolipoprotein binding|apolipoprotein binding|very-low-density lipoprotein particle binding|glycoprotein transporter activity|reelin receptor activity|calcium-dependent protein binding|,10,-0.6,0.463,10,-0.6,0.373,-0.6,0.767,0.536,-6,3
ENSMUSG00000052837,JUNB,jun B proto-oncogene,chromatin|nucleus|nucleoplasm|,"vasculogenesis|osteoblast differentiation|trophectodermal cell differentiation|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|response to light stimulus|response to mechanical stimulus|gene expression|osteoclast differentiation|response to progesterone|cellular response to hormone stimulus|osteoblast proliferation|response to cytokine|response to drug|response to peptide hormone|positive regulation of cell differentiation|positive regulation of transcription from RNA polymerase II promoter|decidualization|response to corticosterone|response to cAMP|regulation of cell cycle|embryonic process involved in female pregnancy|labyrinthine layer blood vessel development|cellular response to calcium ion|",RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein binding|,10,0,0,10,1.3,2.18,1.1,0.765,0.536,-2.5,5.2
ENSMUSG00000032905,ATG12,autophagy related 12,pre-autophagosomal structure membrane|pre-autophagosomal structure membrane|Atg12-Atg5-Atg16 complex|,autophagic vacuole assembly|autophagic vacuole assembly|mitochondrion degradation|C-terminal protein lipidation|cellular response to nitrogen starvation|negative regulation of type I interferon production|nucleophagy|innate immune response|,protein binding|Atg8 ligase activity|,10,-3.5,1.14,10,2.8,2.01,-1.5,0.763,0.537,-6.1,7.1
ENSMUSG00000021068,NIN,ninein (GSK3B interacting protein),spindle pole|nucleolus|centrosome|centriole|microtubule|,microtubule anchoring at centrosome|centrosome localization|centrosome-templated microtubule nucleation|,calcium ion binding|protein binding|GTP binding|,10,-0.8,1.29,10,0,0,-0.6,0.761,0.537,-4.3,1.7
ENSMUSG00000026696,VAMP4,vesicle-associated membrane protein 4,Golgi membrane|lysosome|endosome|trans-Golgi network|cell surface|integral component of membrane|SNARE complex|,SNARE complex assembly|regulation of Golgi to plasma membrane protein transport|Golgi to plasma membrane protein transport|,None,1,-2.2,0.824,0,0,0,-2.2,0.761,0.537,-4,1.6
ENSMUSG00000047515,BC049715,cDNA sequence BC049715,cellular_component|,biological_process|,molecular_function|,1,-2.2,0.824,0,0,0,-2.2,0.761,0.537,-4,1.6
ENSMUSG00000017210,MED24,mediator complex subunit 24,nucleus|nucleoplasm|mediator complex|,"regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|gene expression|histone acetylation|stem cell maintenance|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|positive regulation of transcription, DNA-templated|protein heterooligomerization|",RNA polymerase II transcription cofactor activity|transcription cofactor activity|histone acetyltransferase activity|receptor activity|ligand-dependent nuclear receptor transcription coactivator activity|vitamin D receptor binding|thyroid hormone receptor binding|,9,2.2,2.02,10,-0.8,0.571,3.1,0.756,0.539,-4.4,8.9
ENSMUSG00000047061,GM9817,predicted gene 9817,cellular_component|,biological_process|,molecular_function|,1,-2.8,1.25,1,-0.1,8.36E-06,-2.7,0.754,0.539,-6,1.4
ENSMUSG00000029405,G3BP2,GTPase activating protein (SH3 domain) binding protein 2,cytoplasm|cytoplasm|,cytoplasmic sequestering of NF-kappaB|Ras protein signal transduction|mRNA transport|,nucleotide binding|receptor signaling complex scaffold activity|poly(A) RNA binding|,9,0.9,0.56,10,2.3,0.636,1.1,0.754,0.539,-3.3,5.8
ENSMUSG00000032123,DPAGT1,dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase),endoplasmic reticulum membrane|endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|,UDP-N-acetylglucosamine metabolic process|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|dolichol biosynthetic process|post-translational protein modification|cellular protein metabolic process|protein oligomerization|,"UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|",10,-1.7,1.6,10,0,0,-1.3,0.752,0.54,-7.4,3
ENSMUSG00000049532,SALL2,spalt-like transcription factor 2,NuRD complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|neural tube development|",DNA binding|protein binding|metal ion binding|,1,-2.2,0.813,0,0,0,-2.2,0.751,0.54,-4,1.6
ENSMUSG00000001962,FAM50A,"family with sequence similarity 50, member A",nucleus|nucleus|,spermatogenesis|,poly(A) RNA binding|,1,-1.8,0.699,1,-1.2,0.202,-1.6,0.751,0.54,-4,1.6
ENSMUSG00000028687,MUTYH,mutY homolog,nucleus|nucleoplasm|mitochondrion|,"DNA repair|base-excision repair|base-excision repair, AP site formation|mismatch repair|depurination|","protein binding|hydrolase activity, acting on glycosyl bonds|MutSalpha complex binding|metal ion binding|4 iron, 4 sulfur cluster binding|",10,-1,0.755,10,-0.4,0.135,-0.9,0.751,0.54,-5.6,4.3
ENSMUSG00000019301,HSD17B1,hydroxysteroid (17-beta) dehydrogenase 1,nucleus|cytoplasm|cytosol|nuclear membrane|,steroid biosynthetic process|estrogen biosynthetic process|estrogen biosynthetic process|steroid metabolic process|estrogen metabolic process|small molecule metabolic process|oxidation-reduction process|bone development|testosterone biosynthetic process|cellular response to metal ion|,catalytic activity|estradiol 17-beta-dehydrogenase activity|,10,-0.3,0.0655,10,-1.4,0.98,-0.6,0.75,0.54,-4.9,4.3
ENSMUSG00000024420,ZFP521,zinc finger protein 521,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|cell differentiation|",nucleic acid binding|DNA binding|protein domain specific binding|metal ion binding|,10,-0.5,0.335,10,-1,0.611,-0.7,0.747,0.541,-4.1,2
ENSMUSG00000016349,EEF1A2,eukaryotic translation elongation factor 1 alpha 2,nucleus|eukaryotic translation elongation factor 1 complex|neuronal cell body|,GTP catabolic process|translational elongation|response to inorganic substance|positive regulation of execution phase of apoptosis|,"translation elongation factor activity|GTPase activity|GTP binding|translation factor activity, nucleic acid binding|",9,-1.9,1.68,10,0,0,-1.7,0.747,0.541,-6.5,1.4
ENSMUSG00000024592,C330018D20RIK,RIKEN cDNA C330018D20 gene,mitochondrion|,transport|biological_process|oxidation-reduction process|,molecular_function|,0,0,0,1,1.7,0.807,1.7,0.746,0.541,-1.7,3
ENSMUSG00000035142,NUBPL,nucleotide binding protein-like,mitochondrion|,mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis|,"ATP binding|metal ion binding|4 iron, 4 sulfur cluster binding|",0,0,0,1,1.7,0.807,1.7,0.746,0.541,-1.7,3
ENSMUSG00000025141,MYADML2,myeloid-associated differentiation marker-like 2,cytoplasm|integral component of membrane|,None,None,0,0,0,1,1.7,0.807,1.7,0.746,0.541,-1.7,3
ENSMUSG00000035199,ARL6IP5,ADP-ribosylation factor-like 6 interacting protein 5,endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|extracellular vesicular exosome|,intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of mitochondrial membrane potential|L-glutamate transport|positive regulation of stress-activated MAPK cascade|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transport|,molecular_function|protein C-terminus binding|,0,0,0,1,1.7,0.807,1.7,0.746,0.541,-1.7,3
ENSMUSG00000091813,CES2H,carboxylesterase 2H,cellular_component|,biological_process|,hydrolase activity|carboxylic ester hydrolase activity|,0,0,0,1,1.7,0.807,1.7,0.746,0.541,-1.7,3
ENSMUSG00000028080,LRBA,"LPS-responsive vesicle trafficking, beach and anchor containing",cellular_component|lysosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|membrane|integral component of membrane|cytoplasmic membrane-bounded vesicle|,biological_process|,molecular_function|,10,-2.6,2.31,9,0.2,0.0558,-1.6,0.743,0.542,-7.4,2.4
ENSMUSG00000041491,CEP78,centrosomal protein 78kDa,centrosome|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|,None,10,-0.8,1.54,10,0,0,-0.6,0.742,0.542,-2.9,1.7
ENSMUSG00000072620,SLFN2,schlafen 2,None,negative regulation of cell proliferation|,None,1,-2.2,0.802,0,0,0,-2.2,0.741,0.543,-4,1.6
ENSMUSG00000001225,SLC26A3,"solute carrier family 26 (anion exchanger), member 3",plasma membrane|membrane|integral component of membrane|apical plasma membrane|brush border membrane|sperm midpiece|,"regulation of transcription, DNA-templated|ion transport|anion transport|excretion|bicarbonate transport|sperm capacitation|intracellular pH elevation|transmembrane transport|membrane hyperpolarization|cellular response to cAMP|sulfate transmembrane transport|chloride transmembrane transport|chloride transmembrane transport|regulation of RNA biosynthetic process|",sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transporter activity|protein binding|secondary active sulfate transmembrane transporter activity|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|anion:anion antiporter activity|,1,-2.2,0.802,0,0,0,-2.2,0.741,0.543,-4,1.6
ENSMUSG00000028059,ARHGEF2,Rho/Rac guanine nucleotide exchange factor (GEF) 2,cytoplasm|Golgi apparatus|spindle|cytosol|cytoskeleton|microtubule|tight junction|cytoplasmic membrane-bounded vesicle|vesicle|ruffle membrane|neuronal cell body|dendritic shaft|protein complex|,establishment of mitotic spindle orientation|cell morphogenesis|intracellular protein transport|actin filament organization|negative regulation of microtubule depolymerization|mitotic nuclear division|small GTPase mediated signal transduction|positive regulation of Rho GTPase activity|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of Rac GTPase activity|regulation of Rho protein signal transduction|regulation of cell proliferation|positive regulation of apoptotic process|innate immune response|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of neurogenesis|regulation of small GTPase mediated signal transduction|positive regulation of NF-kappaB transcription factor activity|negative regulation of necroptotic process|cellular response to muramyl dipeptide|cellular response to tumor necrosis factor|cellular hyperosmotic response|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|,Rho guanyl-nucleotide exchange factor activity|protein binding|microtubule binding|transcription factor binding|zinc ion binding|Rho GTPase binding|Rac guanyl-nucleotide exchange factor activity|Rac GTPase binding|,1,-2.2,0.802,0,0,0,-2.2,0.741,0.543,-4,1.6
ENSMUSG00000035245,EOGT,EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase,endoplasmic reticulum lumen|,protein O-linked glycosylation|,protein N-acetylglucosaminyltransferase activity|,1,-2.2,0.802,0,0,0,-2.2,0.741,0.543,-4,1.6
ENSMUSG00000042225,AMMECR1,"Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1",cellular_component|,biological_process|,molecular_function|protein binding|,1,-2.2,0.802,0,0,0,-2.2,0.741,0.543,-4,1.6
ENSMUSG00000040813,TEX264,testis expressed 264,extracellular vesicular exosome|,None,None,10,-2.7,2.25,10,-0.8,0.434,-2.4,0.739,0.543,-8.1,2.7
ENSMUSG00000020866,CACNA1G,"calcium channel, voltage-dependent, T type, alpha 1G subunit",plasma membrane|voltage-gated calcium channel complex|,regulation of heart rate|transport|synaptic transmission|axon guidance|response to nickel cation|regulation of ion transmembrane transport|regulation of membrane potential|positive regulation of calcium ion-dependent exocytosis|regulation of atrial cardiac muscle cell membrane depolarization|calcium ion import|membrane depolarization during action potential|,low voltage-gated calcium channel activity|scaffold protein binding|,10,-0.9,0.0735,10,-0.9,0.729,-0.9,0.739,0.543,-5.1,4
ENSMUSG00000019428,FKBP8,"FK506 binding protein 8, 38kDa",endoplasmic reticulum membrane|membrane|integral component of membrane|mitochondrial membrane|,protein peptidyl-prolyl isomerization|apoptotic process|viral process|intracellular signal transduction|chaperone-mediated protein folding|,peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|identical protein binding|metal ion binding|,10,-1.3,1.31,10,-0.4,0.0545,-0.9,0.738,0.543,-6.2,2.7
ENSMUSG00000029438,BCL7A,B-cell CLL/lymphoma 7A,cellular_component|,"negative regulation of transcription, DNA-templated|",molecular_function|,10,6.7,3.52,10,-0.7,0.578,-0.7,0.734,0.545,-3.4,13.7
ENSMUSG00000031671,SETD6,SET domain containing 6,nucleus|cytoplasm|,peptidyl-lysine monomethylation|negative regulation of NF-kappaB transcription factor activity|regulation of inflammatory response|,protein binding|protein-lysine N-methyltransferase activity|NF-kappaB binding|,0,0,0,1,1.7,0.793,1.7,0.733,0.545,-1.7,3
ENSMUSG00000022751,NIT2,"nitrilase family, member 2",cytoplasm|mitochondrion|centrosome|extracellular vesicular exosome|,oxaloacetate metabolic process|asparagine metabolic process|glutamine metabolic process|,omega-amidase activity|,1,-2.1,0.793,0,0,0,-2.1,0.732,0.545,-4,1.6
ENSMUSG00000031433,RBM41,RNA binding motif protein 41,None,None,nucleotide binding|RNA binding|,1,-2.1,0.793,0,0,0,-2.1,0.732,0.545,-4,1.6
ENSMUSG00000078937,CPT1B,carnitine palmitoyltransferase 1B (muscle),mitochondrion|mitochondrial outer membrane|integral component of membrane|,fatty acid beta-oxidation|carnitine shuttle|cellular lipid metabolic process|small molecule metabolic process|,carnitine O-palmitoyltransferase activity|,10,-1.2,0.303,10,-1.2,0.493,-1.2,0.73,0.546,-8.1,2.5
ENSMUSG00000028437,UBAP1,ubiquitin associated protein 1,ESCRT I complex|cytoplasm|cytosol|,protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|,ubiquitin binding|,0,0,0,1,-2.2,0.79,-2.2,0.729,0.546,-4,1.6
ENSMUSG00000073465,PARK2,parkin RBR E3 ubiquitin protein ligase,ubiquitin ligase complex|nucleus|cytoplasm|mitochondrion|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|aggresome|perinuclear region of cytoplasm|,"protein polyubiquitination|mitochondrion degradation|negative regulation of protein phosphorylation|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|central nervous system development|cell death|regulation of autophagy|protein ubiquitination|negative regulation of actin filament bundle assembly|negative regulation of glucokinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of neuron apoptotic process|cellular protein catabolic process|negative regulation of insulin secretion|protein autoubiquitination|negative regulation of cell death|protein K63-linked ubiquitination|aggresome assembly|protein K48-linked ubiquitination|neuron death|negative regulation of release of cytochrome c from mitochondria|negative regulation of neuron death|regulation of reactive oxygen species metabolic process|",ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|kinase binding|protein kinase binding|PDZ domain binding|ubiquitin protein ligase binding|identical protein binding|ubiquitin binding|chaperone binding|ubiquitin protein ligase activity|ubiquitin-specific protease binding|,10,-2.3,2.06,10,-0.1,0.0169,-1.8,0.729,0.546,-7.7,2.5
ENSMUSG00000029915,CLEC5A,"C-type lectin domain family 5, member A",plasma membrane|integral component of plasma membrane|cell surface|,osteoblast development|cellular defense response|signal transduction|response to virus|response to virus|viral process|negative regulation of myeloid cell apoptotic process|negative regulation of apoptotic process|innate immune response|innate immune response|positive regulation of cytokine secretion|,virus receptor activity|carbohydrate binding|,10,-1,1.12,9,0,0,-0.7,0.728,0.546,-3.7,3.2
ENSMUSG00000021376,TPMT,thiopurine S-methyltransferase,cytosol|extracellular vesicular exosome|,nucleobase-containing compound metabolic process|xenobiotic metabolic process|methylation|response to testosterone|small molecule metabolic process|,thiopurine S-methyltransferase activity|,10,0,0,10,-3.6,1.08,-0.6,0.728,0.546,-9,2.6
ENSMUSG00000045693,NLRP4E,"NLR family, pyrin domain containing 4E",extracellular vesicular exosome|,inflammatory response|biological_process|,nucleotide binding|molecular_function|ATP binding|,8,-2.2,0.923,9,3.6,0.396,-2.1,0.728,0.546,-6.8,6.5
ENSMUSG00000012819,CDH23,cadherin-related 23,plasma membrane|membrane|integral component of membrane|stereocilium|,calcium ion transport|homophilic cell adhesion|visual perception|sensory perception of sound|calcium-dependent cell-cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of light stimulus|equilibrioception|cytosolic calcium ion homeostasis|,calcium ion binding|protein binding|,10,3.9,2.06,10,-1,1.54,-0.8,0.727,0.547,-4,7.8
ENSMUSG00000037731,THEMIS2,thymocyte selection associated family member 2,nucleus|cytoplasm|,inflammatory response|cell adhesion|T cell receptor signaling pathway|,None,10,0,0,10,-3.1,1.37,-2.9,0.727,0.547,-9.4,4.6
ENSMUSG00000029204,RHOH,ras homolog family member H,immunological synapse|cytoplasm|cytosol|plasma membrane|,"regulation of transcription, DNA-templated|small GTPase mediated signal transduction|T cell differentiation|negative regulation of phosphorylation|negative regulation of catalytic activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|mast cell activation|regulation of small GTPase mediated signal transduction|",GTPase inhibitor activity|protein binding|GTP binding|Rho GTPase binding|kinase inhibitor activity|,10,0,0,10,-0.7,1.11,-0.6,0.725,0.547,-6,1.7
ENSMUSG00000038729,AKAP2,A kinase (PRKA) anchor protein 2,None,None,None,10,1.5,0.887,10,0,0,1.2,0.725,0.547,-2.9,5.2
ENSMUSG00000025436,XRCC6BP1,XRCC6 binding protein 1,DNA-dependent protein kinase-DNA ligase 4 complex|,double-strand break repair via nonhomologous end joining|protein phosphorylation|proteolysis|,metalloendopeptidase activity|DNA-dependent protein kinase activity|metal ion binding|,1,-2.1,0.783,0,0,0,-2.1,0.723,0.548,-4,1.6
ENSMUSG00000022314,RAD21,RAD21 homolog (S. pombe),"chromosome, centromeric region|nucleus|nucleoplasm|chromosome|cytosol|cohesin complex|membrane|nuclear meiotic cohesin complex|",mitotic cell cycle|double-strand break repair|DNA recombination|regulation of transcription from RNA polymerase II promoter|apoptotic process|chromosome segregation|mitotic nuclear division|reciprocal meiotic recombination|protein localization to chromatin|,protein binding|,7,1,1.14,8,0.1,0.00578,0.6,0.723,0.548,-2.2,5.2
ENSMUSG00000021576,PDCD6,programmed cell death 6,nucleus|cytoplasm|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic vesicle|nuclear membrane|extracellular vesicular exosome|,angiogenesis|positive regulation of endothelial cell proliferation|proteolysis|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of endothelial cell migration|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of TOR signaling|cellular response to heat|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of angiogenesis|response to calcium ion|negative regulation of protein kinase B signaling|apoptotic signaling pathway|,"calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|protein homodimerization activity|protein dimerization activity|calcium-dependent protein binding|binding, bridging|",1,-2.1,0.783,0,0,0,-2.1,0.723,0.548,-4,1.6
ENSMUSG00000044248,VMN1R45,vomeronasal 1 receptor 45,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|response to pheromone|,signal transducer activity|G-protein coupled receptor activity|pheromone receptor activity|,10,6.4,3.43,9,0,0,-0.7,0.72,0.549,-8,14
ENSMUSG00000022420,DNAL4,"dynein, axonemal, light chain 4",cytoplasm|microtubule|plasma membrane|cilium|dynein complex|,microtubule-based process|metabolic process|neurotrophin TRK receptor signaling pathway|,motor activity|,1,1.5,0.776,0,0,0,1.5,0.717,0.55,-1.6,4
ENSMUSG00000034343,UBE2F,ubiquitin-conjugating enzyme E2F (putative),None,protein neddylation|protein neddylation|,protein binding|ATP binding|NEDD8 ligase activity|,1,1.5,0.776,0,0,0,1.5,0.717,0.55,-1.6,4
ENSMUSG00000019988,NEDD1,"neural precursor cell expressed, developmentally down-regulated 1",centrosome|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|,None,1,1.5,0.776,0,0,0,1.5,0.717,0.55,-1.6,4
ENSMUSG00000075334,RPRM,"reprimo, TP53 dependent G2 arrest mediator candidate",cytoplasm|integral component of membrane|,cell cycle arrest|regulation of mitotic cell cycle|,None,10,-2.3,0.678,10,-0.8,0.342,-0.7,0.716,0.55,-5.1,2.4
ENSMUSG00000035896,RNASE1,"ribonuclease, RNase A family, 1 (pancreatic)",extracellular vesicular exosome|,"RNA phosphodiester bond hydrolysis, endonucleolytic|RNA phosphodiester bond hydrolysis, endonucleolytic|",nucleic acid binding|pancreatic ribonuclease activity|protein binding|,10,-1.5,1.14,10,-0.4,0.195,-0.6,0.716,0.55,-7.7,2.4
ENSMUSG00000031010,USP9X,"ubiquitin specific peptidase 9, X-linked",cytoplasm|cytosol|membrane|growth cone|apical part of cell|,"negative regulation of transcription from RNA polymerase II promoter|neuron migration|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|chromosome segregation|mitotic nuclear division|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|female gamete generation|gene expression|protein deubiquitination|BMP signaling pathway|axon extension|",cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|protein binding|cysteine-type peptidase activity|co-SMAD binding|,10,-0.5,0.374,10,-0.7,0.443,-0.5,0.715,0.55,-4.5,2.4
ENSMUSG00000000869,IL4,interleukin 4,extracellular space|external side of plasma membrane|,"innate immune response in mucosa|T-helper 1 cell lineage commitment|negative regulation of acute inflammatory response|negative regulation of chronic inflammatory response|chemotaxis|immune response|cellular defense response|female pregnancy|response to nutrient|cholesterol metabolic process|regulation of proton transport|response to organic cyclic compound|B cell differentiation|positive regulation of B cell proliferation|B cell costimulation|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|response to cytokine|T-helper 2 cell cytokine production|type 2 immune response|positive regulation of T cell proliferation|positive regulation of activated T cell proliferation|regulation of phosphorylation|response to drug|positive regulation of tyrosine phosphorylation of Stat5 protein|defense response to protozoan|negative regulation of macrophage activation|negative regulation of apoptotic process|negative regulation of nitric oxide biosynthetic process|T-helper 2 cell differentiation|positive regulation of chemokine biosynthetic process|connective tissue growth factor biosynthetic process|regulation of isotype switching|positive regulation of MHC class II biosynthetic process|response to ethanol|positive regulation of T cell differentiation|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|regulation of immune response|positive regulation of sequence-specific DNA binding transcription factor activity|cellular response to mercury ion|dendritic cell differentiation|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of T-helper 17 cell differentiation|negative regulation of extrinsic apoptotic signaling pathway|",cytokine activity|interleukin-4 receptor binding|protein binding|growth factor activity|,10,1.2,0.863,10,-1.8,1.33,0.7,0.713,0.551,-5.2,5.6
ENSMUSG00000031246,SH3BGRL,SH3 domain binding glutamate-rich protein like,extracellular space|nucleus|cytoplasm|extracellular vesicular exosome|,positive regulation of signal transduction|,SH3/SH2 adaptor activity|SH3 domain binding|,0,0,0,1,1.6,0.769,1.6,0.71,0.552,-1.7,3
ENSMUSG00000024645,TIMM21,translocase of inner mitochondrial membrane 21 homolog (yeast),cellular_component|mitochondrial inner membrane presequence translocase complex|integral component of membrane|,protein targeting to mitochondrion|protein import into mitochondrial matrix|mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex IV assembly|cellular protein metabolic process|,molecular_function|protein binding|,0,0,0,1,1.6,0.769,1.6,0.71,0.552,-1.7,3
ENSMUSG00000014245,PIGL,"phosphatidylinositol glycan anchor biosynthesis, class L",endoplasmic reticulum membrane|integral component of membrane|,C-terminal protein lipidation|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,N-acetylglucosaminylphosphatidylinositol deacetylase activity|,0,0,0,1,1.6,0.769,1.6,0.71,0.552,-1.7,3
ENSMUSG00000015092,EDF1,endothelial differentiation-related factor 1,intracellular|nucleus|nucleus|nucleus|transcription factor TFIID complex|nucleolus|cytoplasm|cytoplasm|extracellular vesicular exosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|regulation of lipid metabolic process|positive regulation of DNA binding|endothelial cell differentiation|positive regulation of transcription, DNA-templated|",transcription coactivator activity|protein binding|calmodulin binding|sequence-specific DNA binding|poly(A) RNA binding|,0,0,0,1,1.6,0.769,1.6,0.71,0.552,-1.7,3
ENSMUSG00000038894,IRS2,insulin receptor substrate 2,cytosol|plasma membrane|,positive regulation of mesenchymal cell proliferation|negative regulation of B cell apoptotic process|glucose metabolic process|signal transduction|epidermal growth factor receptor signaling pathway|brain development|cell proliferation|positive regulation of cell proliferation|insulin receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|response to glucose|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of glucose metabolic process|regulation of lipid metabolic process|positive regulation of cell migration|mammary gland development|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of insulin secretion|cellular response to insulin stimulus|negative regulation of kinase activity|Fc-epsilon receptor signaling pathway|innate immune response|positive regulation of glycogen biosynthetic process|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|lipid homeostasis|JAK-STAT cascade involved in growth hormone signaling pathway|cellular response to glucose stimulus|,signal transducer activity|insulin receptor binding|protein binding|protein kinase binding|protein phosphatase binding|protein domain specific binding|phosphatidylinositol 3-kinase binding|14-3-3 protein binding|,10,0.8,0.487,10,0.6,0.3,0.7,0.708,0.553,-2.1,3.4
ENSMUSG00000002393,NR2F6,"nuclear receptor subfamily 2, group F, member 6",nucleus|nucleoplasm|,negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|signal transduction|gene expression|intracellular receptor signaling pathway|intracellular receptor signaling pathway|entrainment of circadian clock by photoperiod|steroid hormone mediated signaling pathway|neuron development|detection of temperature stimulus involved in sensory perception of pain|,DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|thyroid hormone receptor activity|protein binding|zinc ion binding|sequence-specific DNA binding|,10,0.7,0.477,10,0.4,0.348,0.5,0.708,0.553,-5.7,4
ENSMUSG00000030551,NR2F2,"nuclear receptor subfamily 2, group F, member 2",nucleus|,"negative regulation of transcription from RNA polymerase II promoter|neuron migration|maternal placenta development|negative regulation of endothelial cell proliferation|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|lipid metabolic process|signal transduction|skeletal muscle tissue development|fertilization|anterior/posterior pattern specification|radial pattern formation|negative regulation of endothelial cell migration|intracellular receptor signaling pathway|intracellular receptor signaling pathway|intracellular receptor signaling pathway|forebrain development|response to estradiol|steroid hormone mediated signaling pathway|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|blood vessel morphogenesis|limb development|placenta blood vessel development|trophoblast giant cell differentiation|regulation of transcription involved in lymphatic endothelial cell fate commitment|",retinoic acid binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|protein homodimerization activity|sequence-specific DNA binding|,10,-0.6,0.483,10,-0.7,0.291,-0.6,0.707,0.553,-7.5,3.2
ENSMUSG00000027353,MCM8,minichromosome maintenance complex component 8,nucleus|nucleoplasm|MCM8-MCM9 complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|double-strand break repair via homologous recombination|DNA replication|DNA strand elongation involved in DNA replication|cellular response to DNA damage stimulus|female gamete generation|male gamete generation|,DNA binding|helicase activity|protein binding|ATP binding|,10,-0.5,0.155,10,1.3,2.14,1,0.706,0.554,-8.5,4.4
ENSMUSG00000029377,EREG,epiregulin,extracellular region|extracellular space|integral component of plasma membrane|,"angiogenesis|ovarian cumulus expansion|oocyte maturation|positive regulation of cytokine production|female meiotic division|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor signaling pathway|cell-cell signaling|positive regulation of cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|mRNA transcription|anatomical structure morphogenesis|organ morphogenesis|cytokine-mediated signaling pathway|keratinocyte differentiation|ovulation|Fc-epsilon receptor signaling pathway|wound healing|positive regulation of cytokine biosynthetic process|positive regulation of phosphorylation|positive regulation of phosphorylation|luteinizing hormone signaling pathway|response to peptide hormone|keratinocyte proliferation|innate immune response|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of DNA replication|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitosis|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|primary follicle stage|positive regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|positive regulation of cell division|",epidermal growth factor receptor binding|epidermal growth factor receptor binding|protein binding|growth factor activity|,10,-1.3,0.371,10,-0.6,0.572,-1.1,0.705,0.554,-7.4,7.7
ENSMUSG00000030610,DET1,de-etiolated homolog 1 (Arabidopsis),nucleus|,None,None,9,4.1,0.583,10,1.2,1.28,1,0.705,0.554,-5.9,7.7
ENSMUSG00000034674,TDG,thymine-DNA glycosylase,nucleus|nucleoplasm|plasma membrane|PML body|,"negative regulation of transcription from RNA polymerase II promoter|DNA repair|base-excision repair|base-excision repair|base-excision repair, AP site formation|mismatch repair|transcription from RNA polymerase II promoter|embryo development|chromatin modification|negative regulation of protein binding|negative regulation of chromatin binding|regulation of gene expression, epigenetic|depyrimidination|DNA demethylation|",RNA polymerase II transcription cofactor activity|damaged DNA binding|double-stranded DNA binding|protein kinase C binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|DNA N-glycosylase activity|mismatched DNA binding|SUMO binding|protein homodimerization activity|structure-specific DNA binding|,10,-2,0.59,10,-2,0.177,-2,0.705,0.554,-9,6.7
ENSMUSG00000013662,ATAD1,"ATPase family, AAA domain containing 1",mitochondrion|peroxisomal membrane|membrane|cell junction|postsynaptic membrane|,"positive regulation of receptor internalization|ATP catabolic process|learning|memory|negative regulation of synaptic transmission, glutamatergic|",ATP binding|ATPase activity|,1,-2.1,0.764,0,0,0,-2.1,0.705,0.554,-4,1.6
ENSMUSG00000017002,SLPI,secretory leukocyte peptidase inhibitor,extracellular matrix|extracellular vesicular exosome|,negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|negative regulation of protein binding|negative regulation of viral genome replication|,endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|enzyme binding|,1,-2.1,0.764,0,0,0,-2.1,0.705,0.554,-4,1.6
ENSMUSG00000009073,NF2,neurofibromin 2 (merlin),nucleus|nucleolus|cytoplasm|early endosome|cytoskeleton|plasma membrane|adherens junction|membrane|extrinsic component of membrane|lamellipodium|cortical actin cytoskeleton|filopodium membrane|cleavage furrow|ruffle membrane|perinuclear region of cytoplasm|,mesoderm formation|negative regulation of cell-matrix adhesion|negative regulation of protein kinase activity|ectoderm development|negative regulation of DNA replication|negative regulation of cell proliferation|negative regulation of cell proliferation|Schwann cell proliferation|negative regulation of cell-cell adhesion|actin cytoskeleton organization|negative regulation of cell migration|regulation of hippo signaling|odontogenesis of dentin-containing tooth|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|negative regulation of MAPK cascade|cell-cell junction organization|negative regulation of JAK-STAT cascade|positive regulation of stress fiber assembly|lens fiber cell differentiation|,actin binding|protein binding|,10,-0.7,0.571,10,-0.8,0.201,-0.7,0.704,0.555,-4.3,1.7
ENSMUSG00000026239,PDE6D,"phosphodiesterase 6D, cGMP-specific, rod, delta",cytosol|cytoplasmic vesicle membrane|cytoplasmic vesicle|,visual perception|metabolic process|regulation of GTP catabolic process|negative regulation of catalytic activity|negative regulation of catalytic activity|response to stimulus|,"3',5'-cyclic-nucleotide phosphodiesterase activity|GTPase inhibitor activity|protein binding|Rab GTPase binding|",10,-6.6,2.94,10,0,0,-0.9,0.703,0.555,-13,3.7
ENSMUSG00000049583,GRM5,"glutamate receptor, metabotropic 5",cytoplasm|plasma membrane|integral component of plasma membrane|postsynaptic density|dendritic spine|dendritic shaft|extracellular vesicular exosome|astrocyte projection|,"activation of MAPKKK activity|desensitization of G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-templated|protein phosphorylation|protein kinase C-activating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|synaptic transmission|learning|locomotory behavior|negative regulation of locomotion|positive regulation of long-term neuronal synaptic plasticity|cognition|regulation of synaptic transmission, glutamatergic|",G-protein coupled receptor activity|glutamate receptor activity|A2A adenosine receptor binding|,10,-4.8,1.36,10,1.3,1.59,1.1,0.702,0.555,-8.2,4
ENSMUSG00000005583,MEF2C,myocyte enhancer factor 2C,nucleus|nucleoplasm|cytoplasm|cytosol|nuclear speck|sarcomere|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|MAPK cascade|blood vessel development|osteoblast differentiation|neuron migration|B cell homeostasis|heart looping|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|toll-like receptor signaling pathway|germinal center formation|regulation of germinal center formation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|response to ischemia|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|sinoatrial valve morphogenesis|cardiac ventricle formation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|apoptotic process|humoral immune response|nervous system development|heart development|heart development|heart development|muscle organ development|skeletal muscle tissue development|muscle cell fate determination|learning or memory|response to virus|positive regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of gene expression|positive regulation of alkaline phosphatase activity|neural crest cell differentiation|cardiac muscle hypertrophy in response to stress|myotube differentiation|dentate gyrus development|neuron differentiation|neuron differentiation|platelet formation|monocyte differentiation|negative regulation of ossification|melanocyte differentiation|positive regulation of bone mineralization|positive regulation of B cell proliferation|response to vitamin E|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|cellular response to drug|cellular response to trichostatin A|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|B cell proliferation|muscle cell differentiation|positive regulation of MAP kinase activity|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|innate immune response|regulation of megakaryocyte differentiation|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of neurotransmitter secretion|neurotrophin TRK receptor signaling pathway|regulation of synaptic plasticity|positive regulation of skeletal muscle tissue development|neuron development|cell morphogenesis involved in neuron differentiation|embryonic viscerocranium morphogenesis|negative regulation of epithelial cell proliferation|B cell receptor signaling pathway|smooth muscle cell differentiation|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|regulation of synapse assembly|regulation of synaptic transmission, glutamatergic|ventricular cardiac muscle cell differentiation|palate development|regulation of synaptic activity|positive regulation of cardiac muscle cell proliferation|regulation of excitatory postsynaptic membrane potential|regulation of sarcomere organization|cartilage morphogenesis|regulation of dendritic spine development|renal tubule morphogenesis|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to retinoic acid|cellular response to glucose stimulus|cellular response to parathyroid hormone stimulus|cellular response to fluid shear stress|cellular response to transforming growth factor beta stimulus|positive regulation of cell proliferation in bone marrow|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|positive regulation of protein homodimerization activity|positive regulation of macrophage apoptotic process|regulation of N-methyl-D-aspartate selective glutamate receptor activity|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|positive regulation of cardiac muscle cell differentiation|positive regulation of behavioral fear response|epithelial cell proliferation involved in renal tubule morphogenesis|positive regulation of skeletal muscle cell differentiation|",RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|AT DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|activating transcription factor binding|miRNA binding|histone deacetylase binding|transcription regulatory region DNA binding|protein heterodimerization activity|HMG box domain binding|,9,-3.4,1.28,10,-0.8,0.295,-1.3,0.702,0.555,-6.7,7
ENSMUSG00000091002,TCERG1L,transcription elongation regulator 1-like,None,None,None,10,-0.3,0.0694,10,-1.1,0.905,-0.7,0.702,0.555,-4,1.4
ENSMUSG00000015134,ALDH1A3,"aldehyde dehydrogenase 1 family, member A3",cytoplasm|,optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|locomotory behavior|nucleus accumbens development|inner ear morphogenesis|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|positive regulation of apoptotic process|embryonic eye morphogenesis|neuromuscular process controlling balance|oxidation-reduction process|righting reflex|olfactory pit development|face development|,aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|protein homodimerization activity|thyroid hormone binding|NAD+ binding|,10,-0.5,0.235,10,-0.7,0.547,-0.6,0.699,0.556,-6.3,5
ENSMUSG00000032127,VPS11,vacuolar protein sorting 11 homolog (S. cerevisiae),lysosomal membrane|endosome|endocytic vesicle|HOPS complex|late endosome membrane|,intracellular protein transport|vesicle-mediated transport|,nucleotide binding|protein binding|zinc ion binding|,0,0,0,1,-2.2,0.757,-2.2,0.699,0.556,-4,1.6
ENSMUSG00000029554,MAD1L1,MAD1 mitotic arrest deficient-like 1 (yeast),kinetochore|kinetochore|condensed chromosome kinetochore|nucleus|nuclear pore|cytoplasm|centrosome|spindle|cytosol|actin cytoskeleton|mitotic spindle|,mitotic metaphase|mitotic anaphase|mitotic telophase|mitotic cell cycle|mitotic nuclear division|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|regulation of metaphase plate congression|,protein binding|,10,-0.6,0.576,10,2.2,0.647,-0.6,0.698,0.556,-3.3,6
ENSMUSG00000001943,VSIG2,V-set and immunoglobulin domain containing 2,integral component of plasma membrane|membrane|,None,None,1,-2,0.755,0,0,0,-2,0.697,0.557,-4,1.6
ENSMUSG00000030189,YBX3,Y box binding protein 3,nucleus|cytoplasm|polysome|tight junction|perinuclear region of cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|transcription, DNA-templated|spermatogenesis|male gonad development|response to cold|fertilization|negative regulation of apoptotic process|positive regulation of organ growth|negative regulation of skeletal muscle tissue development|negative regulation of necroptotic process|3'-UTR-mediated mRNA stabilization|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of cytoplasmic translation|",double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|mRNA 3'-UTR binding|Rho GTPase binding|poly(A) RNA binding|,10,-2.6,1.12,10,-0.4,0.205,-0.5,0.697,0.557,-5.5,2.8
ENSMUSG00000022504,CIITA,"class II, major histocompatibility complex, transactivator",nucleoplasm|cell surface|PML body|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|inflammatory response|immune response|aging|phosphorylation|cytokine-mediated signaling pathway|negative regulation of collagen biosynthetic process|response to interferon-gamma|positive regulation of MHC class I biosynthetic process|positive regulation of MHC class II biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|interferon-gamma-mediated signaling pathway|cellular response to electrical stimulus|cellular response to exogenous dsRNA|","transcription coactivator activity|protein binding|ATP binding|GTP binding|protein C-terminus binding|kinase activity|transferase activity, transferring acyl groups|protein complex binding|activating transcription factor binding|transcription regulatory region DNA binding|",10,0.7,0.603,10,0.5,0.164,0.6,0.694,0.557,-3.1,3.9
ENSMUSG00000039304,TNFSF10,"tumor necrosis factor (ligand) superfamily, member 10",extracellular region|extracellular space|integral component of plasma membrane|extracellular vesicular exosome|,apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|cell-cell signaling|male gonad development|response to insulin|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|metal ion binding|,10,-1.7,0.272,10,-2,0.526,-1.8,0.692,0.558,-6.9,3
ENSMUSG00000035262,AMH,anti-Mullerian hormone,extracellular region|extracellular space|cytoplasm|,preantral ovarian follicle growth|urogenital system development|Mullerian duct regression|Mullerian duct regression|cell-cell signaling|gonadal mesoderm development|sex determination|sex differentiation|aging|positive regulation of gene expression|response to organic cyclic compound|response to drug|positive regulation of NF-kappaB transcription factor activity|,receptor binding|transforming growth factor beta receptor binding|hormone activity|growth factor activity|,10,1.5,1.35,10,-0.5,0.0601,1.2,0.692,0.558,-3.9,5
ENSMUSG00000024507,HSD17B4,hydroxysteroid (17-beta) dehydrogenase 4,mitochondrion|peroxisome|peroxisome|peroxisomal membrane|peroxisomal matrix|membrane|intracellular membrane-bounded organelle|,very long-chain fatty acid metabolic process|osteoblast differentiation|fatty acid beta-oxidation|bile acid biosynthetic process|metabolic process|bile acid metabolic process|androgen metabolic process|estrogen metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|unsaturated fatty acid metabolic process|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA metabolic process|medium-chain fatty-acyl-CoA metabolic process|cellular lipid metabolic process|small molecule metabolic process|oxidation-reduction process|oxidation-reduction process|Sertoli cell development|,"3-hydroxyacyl-CoA dehydrogenase activity|3-hydroxyacyl-CoA dehydrogenase activity|3-hydroxyacyl-CoA dehydrogenase activity|receptor binding|long-chain-enoyl-CoA hydratase activity|long-chain-enoyl-CoA hydratase activity|isomerase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|protein homodimerization activity|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|",10,5.5,2.07,10,-1.1,1.63,-0.7,0.689,0.559,-3.9,11.1
ENSMUSG00000038236,HOXA7,homeobox A7,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of leukocyte migration|transcription, DNA-templated|anterior/posterior pattern specification|negative regulation of keratinocyte differentiation|negative regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|stem cell differentiation|",sequence-specific DNA binding transcription factor activity|transcription factor binding|sequence-specific DNA binding|,1,-2,0.747,0,0,0,-2,0.689,0.559,-4,1.6
ENSMUSG00000042179,PNLIPRP1,pancreatic lipase-related protein 1,extracellular region|,lipid metabolic process|,triglyceride lipase activity|calcium ion binding|,0,0,0,1,-2.2,0.746,-2.2,0.689,0.559,-4,1.6
ENSMUSG00000063133,KLK1B1,kallikrein 1-related peptidase b1,nucleus|,tissue kallikrein-kinin cascade|bradykinin biosynthetic process|regulation of systemic arterial blood pressure|left ventricular cardiac muscle tissue morphogenesis|proteolysis|vasodilation|cardiac muscle contraction|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,2.5,2.23,10,0.2,0.118,1.7,0.687,0.56,-4.6,7
ENSMUSG00000079415,CNTF,ciliary neurotrophic factor,extracellular space|cytoplasm|CRLF-CLCF1 complex|,signal transduction|positive regulation of cell proliferation|growth|positive regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of neuron apoptotic process|negative regulation of photoreceptor cell differentiation|regulation of retinal cell programmed cell death|muscle organ morphogenesis|neuron development|ciliary neurotrophic factor-mediated signaling pathway|,ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|growth factor activity|,10,0.6,0.667,10,-0.6,0.574,-0.6,0.685,0.56,-3.7,2.4
ENSMUSG00000037465,KLF10,Kruppel-like factor 10,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|cell-cell signaling|cell proliferation|negative regulation of cell proliferation|bone mineralization|somatic stem cell maintenance|positive regulation of osteoclast differentiation|cellular response to peptide|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|metal ion binding|,10,-0.4,0.194,10,-3.8,1.35,-2.7,0.684,0.56,-7.8,3.3
ENSMUSG00000017119,NBR1,neighbor of BRCA1 gene 1,pre-autophagosomal structure|lysosome|late endosome|autophagic vacuole|cytosol|membrane|cytoplasmic vesicle|M band|extracellular vesicular exosome|,macroautophagy|regulation of bone mineralization|regulation of stress-activated MAPK cascade|negative regulation of osteoblast differentiation|protein oligomerization|,protein binding|zinc ion binding|ubiquitin binding|mitogen-activated protein kinase binding|,10,1.2,0.339,9,1.2,0.405,1.2,0.682,0.561,-2.9,6.2
ENSMUSG00000048701,CCDC6,coiled-coil domain containing 6,cytoplasm|cytoskeleton|,biological_process|,structural constituent of cytoskeleton|protein binding|SH3 domain binding|,10,-4.2,1.61,10,-0.3,0.126,-0.7,0.68,0.561,-11.2,3.4
ENSMUSG00000021318,GLI3,GLI family zinc finger 3,nucleus|cytoplasm|cytosol|cilium|mediator complex|nuclear speck|transcriptional repressor complex|primary cilium|,"negative regulation of transcription from RNA polymerase II promoter|metanephros development|branching involved in ureteric bud morphogenesis|in utero embryonic development|positive regulation of neuroblast proliferation|transcription, DNA-templated|smoothened signaling pathway|axon guidance|hindgut morphogenesis|heart development|negative regulation of cell proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|protein processing|optic nerve morphogenesis|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|forebrain dorsal/ventral pattern formation|cerebral cortex radial glia guided migration|forebrain radial glial cell differentiation|lateral ganglionic eminence cell proliferation|melanocyte differentiation|lung development|positive regulation of chondrocyte differentiation|T cell differentiation in thymus|limb morphogenesis|wound healing|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|negative regulation of apoptotic process|nose morphogenesis|tongue development|response to estrogen|negative thymic T cell selection|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|embryonic digestive tract morphogenesis|embryonic digestive tract development|developmental growth|camera-type eye morphogenesis|embryonic skeletal system morphogenesis|oligodendrocyte differentiation|palate development|frontal suture morphogenesis|lambdoid suture morphogenesis|sagittal suture morphogenesis|mammary gland specification|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|artery development|anterior semicircular canal development|lateral semicircular canal development|cell differentiation involved in kidney development|thymocyte apoptotic process|negative regulation of canonical Wnt signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|metal ion binding|,10,1.4,1.13,10,0.3,0.0743,1,0.678,0.562,-2,6.4
ENSMUSG00000025986,SLC39A10,"solute carrier family 39 (zinc transporter), member 10",integral component of membrane|,zinc ion transport|transmembrane transport|,metal ion transmembrane transporter activity|,0,0,0,1,1.6,0.734,1.6,0.677,0.562,-1.7,3
ENSMUSG00000022707,GBE1,"glucan (1,4-alpha-), branching enzyme 1",cytosol|extracellular vesicular exosome|,carbohydrate metabolic process|glycogen metabolic process|glycogen biosynthetic process|glycogen biosynthetic process|glucose metabolic process|generation of precursor metabolites and energy|small molecule metabolic process|,"1,4-alpha-glucan branching enzyme activity|hydrolase activity, hydrolyzing O-glycosyl compounds|cation binding|",10,5.5,1.96,10,0.8,0.115,0.6,0.677,0.562,-1.5,11.3
ENSMUSG00000046049,RP1L1,retinitis pigmentosa 1-like 1,photoreceptor outer segment|microtubule|axoneme|photoreceptor connecting cilium|extracellular vesicular exosome|,visual perception|cell projection organization|intracellular signal transduction|photoreceptor cell development|photoreceptor cell maintenance|photoreceptor cell maintenance|,None,10,2.3,1.63,10,0.5,0.198,1,0.676,0.562,-2.3,5.5
ENSMUSG00000002413,BRAF,"B-Raf proto-oncogene, serine/threonine kinase",nucleus|cytosol|plasma membrane|neuron projection|,MAPK cascade|activation of MAPKK activity|protein phosphorylation|small GTPase mediated signal transduction|synaptic transmission|fibroblast growth factor receptor signaling pathway|organ morphogenesis|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|negative regulation of apoptotic process|response to peptide hormone|negative regulation of neuron apoptotic process|neurotrophin TRK receptor signaling pathway|protein heterooligomerization|response to cAMP|positive regulation of ERK1 and ERK2 cascade|response to epidermal growth factor|cellular response to calcium ion|,protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|calcium ion binding|protein binding|ATP binding|mitogen-activated protein kinase kinase binding|identical protein binding|protein heterodimerization activity|,0,0,0,1,-2.1,0.732,-2.1,0.675,0.563,-4,1.6
ENSMUSG00000022012,ENOX1,ecto-NOX disulfide-thiol exchanger 1,extracellular space|plasma membrane|,rhythmic process|oxidation-reduction process|,nucleotide binding|nucleic acid binding|oxidoreductase activity|,0,0,0,1,-2.1,0.732,-2.1,0.675,0.563,-4,1.6
ENSMUSG00000073542,CEP76,centrosomal protein 76kDa,centrosome|centriole|cytosol|protein complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|regulation of centriole replication|,protein binding|,10,4.6,0.117,10,1.7,1.89,1.6,0.673,0.563,-5.2,10
ENSMUSG00000002900,LAMB1,"laminin, beta 1",extracellular region|basement membrane|basement membrane|laminin-1 complex|laminin-1 complex|laminin-1 complex|laminin-2 complex|laminin-2 complex|extracellular space|extracellular matrix|laminin-8 complex|laminin-8 complex|laminin-10 complex|perinuclear region of cytoplasm|extracellular vesicular exosome|,cell adhesion|negative regulation of cell adhesion|axon guidance|embryo implantation|neuronal-glial interaction involved in cerebral cortex radial glia guided migration|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell migration|neuron projection development|substrate adhesion-dependent cell spreading|odontogenesis|positive regulation of epithelial cell proliferation|,integrin binding|structural molecule activity|extracellular matrix structural constituent|enzyme binding|glycosphingolipid binding|,10,-0.4,0.222,9,-0.7,0.57,-0.5,0.67,0.564,-5.3,2.3
ENSMUSG00000046449,C77370,expressed sequence C77370,nucleus|delta DNA polymerase complex|,"mitotic S phase|base-excision repair, gap-filling|nucleotide-excision repair, DNA gap filling|multicellular organismal development|regulation of mitotic cell cycle|nervous system development|DNA replication, removal of RNA primer|DNA replication proofreading|DNA biosynthetic process|nucleic acid phosphodiester bond hydrolysis|",DNA-directed DNA polymerase activity|3'-5' exonuclease activity|,10,0.7,0.687,10,0.4,0.0734,0.6,0.669,0.565,-2.7,5.8
ENSMUSG00000002257,DEF6,differentially expressed in FDCP 6 homolog (mouse),nucleus|cytoplasm|plasma membrane|membrane|,None,None,10,1.2,0.95,10,0.1,0.00183,0.9,0.669,0.565,-2.1,4.8
ENSMUSG00000039850,ENDOV,endonuclease V,nucleolus|cytoplasm|,"DNA catabolic process, endonucleolytic|DNA repair|RNA phosphodiester bond hydrolysis, endonucleolytic|","magnesium ion binding|magnesium ion binding|single-stranded RNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|endoribonuclease activity, producing 5'-phosphomonoesters|structure-specific DNA binding|",10,-1.6,1.02,10,0,0,-1.7,0.669,0.565,-7,4.3
ENSMUSG00000061397,KRT79,keratin 79,keratin filament|extracellular vesicular exosome|,None,structural molecule activity|enzyme binding|,1,-1.9,0.722,0,0,0,-1.9,0.666,0.566,-4,1.6
ENSMUSG00000023964,CALCR,calcitonin receptor,plasma membrane|integral component of plasma membrane|,G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein transport|positive regulation of cAMP biosynthetic process|receptor internalization|positive regulation of adenylate cyclase activity|response to glucocorticoid|protein localization to plasma membrane|,receptor activity|calcitonin receptor activity|calcitonin receptor activity|protein binding|protein transporter activity|calcitonin binding|calcitonin binding|,10,0.4,0.145,9,-0.7,0.797,-0.9,0.666,0.566,-3.9,4
ENSMUSG00000032041,TIRAP,toll-interleukin 1 receptor (TIR) domain containing adaptor protein,cytoplasm|cytosol|plasma membrane|plasma membrane|endocytic vesicle|ruffle membrane|,toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|inflammatory response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|myeloid cell differentiation|positive regulation of B cell proliferation|response to lipopolysaccharide|regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|TIRAP-dependent toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of growth of symbiont in host|innate immune response|regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of JNK cascade|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|positive regulation of neutrophil chemotaxis|positive regulation of protein homodimerization activity|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|,"protein kinase C binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|Toll-like receptor 4 binding|Toll-like receptor 2 binding|protein homodimerization activity|protein heterodimerization activity|",1,1.5,0.72,0,0,0,1.5,0.664,0.566,-1.6,4
ENSMUSG00000026182,TNP1,transition protein 1 (during histone to protamine replacement),nucleosome|male germ cell nucleus|,"single strand break repair|nucleosome disassembly|chromatin remodeling|chromatin silencing|multicellular organismal development|spermatid development|spermatid nucleus differentiation|spermatid nucleus elongation|sexual reproduction|sperm motility|fertilization, exchange of chromosomal proteins|negative regulation of transcription, DNA-templated|",DNA binding|,10,-0.3,0.238,10,-0.7,0.554,-0.5,0.663,0.567,-4.8,4.6
ENSMUSG00000041147,BRCA2,"breast cancer 2, early onset",nucleus|nucleoplasm|cytoplasm|centrosome|secretory granule|BRCA2-MAGE-D1 complex|protein complex|,"double-strand break repair via homologous recombination|double-strand break repair via homologous recombination|cytokinesis|oocyte maturation|inner cell mass cell proliferation|DNA repair|nucleotide-excision repair|double-strand break repair|double-strand break repair|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|male meiosis I|spermatogenesis|brain development|cell aging|female gonad development|response to X-ray|response to UV-C|response to gamma radiation|hemopoiesis|regulation of cytokinesis|negative regulation of mammary gland epithelial cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|replication fork protection|centrosome duplication|",protease binding|single-stranded DNA binding|protein binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|gamma-tubulin binding|,10,3.5,0.619,9,-1.4,1.66,-1.1,0.662,0.567,-4.6,7.8
ENSMUSG00000019817,PLAGL1,pleiomorphic adenoma gene-like 1,nucleus|nucleus|cytoplasm|Golgi apparatus|,transcription from RNA polymerase II promoter|apoptotic process|cell cycle arrest|cell differentiation|skeletal muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|,RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|metal ion binding|,10,-1.2,1.41,10,0.8,1.16,0.6,0.662,0.567,-5.2,3.8
ENSMUSG00000042212,SPRR2D,small proline-rich protein 2D,cornified envelope|cytoplasm|,epidermis development|keratinization|,None,0,0,0,2,-2.4,0.717,-2.4,0.662,0.567,-5,3.5
ENSMUSG00000039217,IL18,interleukin 18,extracellular region|extracellular space|cytosol|extracellular vesicular exosome|,MAPK cascade|angiogenesis|inflammatory response|immune response|cell-cell signaling|positive regulation of gene expression|natural killer cell activation|regulation of cell adhesion|sleep|lipopolysaccharide-mediated signaling pathway|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|chemokine biosynthetic process|T-helper 1 type immune response|type 2 immune response|interleukin-2 biosynthetic process|interferon-gamma biosynthetic process|positive regulation of activated T cell proliferation|interleukin-13 biosynthetic process|granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of NF-kappaB import into nucleus|positive regulation of inflammatory response|positive regulation of NK T cell proliferation|cellular response to organic cyclic compound|,cytokine activity|,10,0.8,0.711,10,0.3,0.129,0.6,0.661,0.567,-2,2.8
ENSMUSG00000021506,PITX1,paired-like homeodomain 1,nucleus|transcription factor complex|nucleolus|cytoplasm|,"skeletal system development|transcription, DNA-templated|anatomical structure morphogenesis|branchiomeric skeletal muscle development|pituitary gland development|embryonic hindlimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|myoblast fate commitment|cartilage development|",RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-1.9,0.714,0,0,0,-1.9,0.659,0.568,-4,1.6
ENSMUSG00000029708,GCC1,GRIP and coiled-coil domain containing 1,Golgi membrane|cytoplasm|Golgi apparatus|plasma membrane|,protein targeting to Golgi|,protein binding|,1,-1.9,0.714,0,0,0,-1.9,0.659,0.568,-4,1.6
ENSMUSG00000005371,FBXO11,F-box protein 11,ubiquitin ligase complex|nucleus|chromosome|nucleolus|cytoplasm|,cellular protein modification process|ubiquitin-dependent protein catabolic process|sensory perception of sound|protein ubiquitination|protein ubiquitination|peptidyl-arginine N-methylation|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|protein-arginine N-methyltransferase activity|,1,-1.9,0.714,0,0,0,-1.9,0.659,0.568,-4,1.6
ENSMUSG00000038276,ASIC3,acid-sensing (proton-gated) ion channel 3,cytoplasm|plasma membrane|integral component of plasma membrane|,response to acid|transport|signal transduction|sensory perception|response to heat|ion transmembrane transport|sodium ion transmembrane transport|sodium ion transmembrane transport|enterobactin transport|sensory perception of sour taste|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|detection of chemical stimulus involved in sensory perception of pain|transmembrane transport|,cation channel activity|sodium channel activity|ligand-gated sodium channel activity|PDZ domain binding|enterobactin transporter activity|,1,-1.9,0.714,0,0,0,-1.9,0.659,0.568,-4,1.6
ENSMUSG00000032172,OLFM2,olfactomedin 2,extracellular region|cell junction|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|synapse|,protein secretion|,None,0,0,0,1,-2.1,0.709,-2.1,0.654,0.57,-4,1.6
ENSMUSG00000020092,PALD1,"phosphatase domain containing, paladin 1",cytosol|,None,protein binding|,0,0,0,1,-2.1,0.709,-2.1,0.654,0.57,-4,1.6
ENSMUSG00000018217,PMP22,peripheral myelin protein 22,plasma membrane|tight junction|integral component of membrane|compact myelin|,synaptic transmission|peripheral nervous system development|cell death|negative regulation of cell proliferation|negative regulation of neuron projection development|myelin assembly|,protein binding|,10,0.9,0.745,10,0.3,0.0952,0.7,0.653,0.57,-3.3,5.1
ENSMUSG00000068890,LCE1A2,late cornified envelope 1A2,cellular_component|,biological_process|,protein binding|identical protein binding|,1,-1.9,0.707,0,0,0,-1.9,0.652,0.57,-4,1.7
ENSMUSG00000048000,GIGYF2,GRB10 interacting GYF protein 2,membrane|,feeding behavior|cell death|adult locomotory behavior|post-embryonic development|negative regulation of translation|spinal cord motor neuron differentiation|mitotic G1 DNA damage checkpoint|multicellular organism growth|cellular protein metabolic process|insulin-like growth factor receptor signaling pathway|homeostasis of number of cells within a tissue|musculoskeletal movement|neuromuscular process controlling balance|,poly(A) RNA binding|,1,-1.9,0.707,0,0,0,-1.9,0.652,0.57,-4,1.7
ENSMUSG00000034205,LOXL2,lysyl oxidase-like 2,basement membrane|extracellular space|nucleus|nucleus|chromosome|membrane|,"response to hypoxia|epithelial to mesenchymal transition|endothelial cell proliferation|sprouting angiogenesis|transcription, DNA-templated|cellular protein modification process|receptor-mediated endocytosis|cell adhesion|aging|histone modification|protein deamination|collagen fibril organization|positive regulation of chondrocyte differentiation|endothelial cell migration|negative regulation of transcription, DNA-templated|response to copper ion|oxidation-reduction process|",chromatin binding|transcription corepressor activity|protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|electron carrier activity|methylated histone binding|oligosaccharide binding|,10,-0.1,0.00616,10,-1.4,1.05,-0.6,0.652,0.57,-4.9,1.7
ENSMUSG00000049653,SPATC1,spermatogenesis and centriole associated 1,cytoplasm|centrosome|,None,gamma-tubulin binding|,10,-0.5,0.395,10,-0.7,0.324,-0.6,0.652,0.57,-9.3,5.4
ENSMUSG00000036751,COX6B1,cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous),mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|,substantia nigra development|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|hydrogen ion transmembrane transport|hydrogen ion transmembrane transport|,cytochrome-c oxidase activity|,10,0,0,10,-1.2,1.36,-1.2,0.651,0.571,-4.1,1.4
ENSMUSG00000056608,CHD9,chromodomain helicase DNA binding protein 9,nucleoplasm|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|chromatin modification|cellular lipid metabolic process|small molecule metabolic process|",DNA binding|helicase activity|protein binding|ATP binding|,10,-2,0.344,10,-1,0.824,-1,0.65,0.571,-5.4,2.8
ENSMUSG00000020515,CNOT8,"CCR4-NOT transcription complex, subunit 8",intracellular|nucleus|cytosol|CCR4-NOT complex|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translation|positive regulation of cell proliferation|negative regulation of cell proliferation|gene expression|RNA metabolic process|mRNA metabolic process|gene silencing by miRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|RNA phosphodiester bond hydrolysis, exonucleolytic|RNA phosphodiester bond hydrolysis, exonucleolytic|",3'-5'-exoribonuclease activity|sequence-specific DNA binding transcription factor activity|RNA binding|poly(A)-specific ribonuclease activity|protein binding|metal ion binding|,10,-4.3,0.57,10,-1.8,0.697,-1.8,0.648,0.571,-9.2,4.4
ENSMUSG00000040434,GYLTL1B,glycosyltransferase-like 1B,Golgi membrane|integral component of membrane|,metabolic process|muscle cell cellular homeostasis|,"transferase activity, transferring glycosyl groups|",1,-1.8,0.699,0,0,0,-1.8,0.645,0.572,-4,1.7
ENSMUSG00000035208,SLFN8,schlafen 8,intracellular|,biological_process|,molecular_function|,1,-1.8,0.699,0,0,0,-1.8,0.645,0.572,-4,1.7
ENSMUSG00000047604,FRAT2,frequently rearranged in advanced T-cell lymphomas 2,cellular_component|,multicellular organismal development|cell proliferation|Wnt signaling pathway|,molecular_function|,1,-1.8,0.699,0,0,0,-1.8,0.645,0.572,-4,1.7
ENSMUSG00000027857,TSHB,"thyroid stimulating hormone, beta",extracellular region|,G-protein coupled receptor signaling pathway|cell-cell signaling|anatomical structure morphogenesis|peptide hormone processing|response to vitamin A|response to estrogen|cellular protein metabolic process|response to calcium ion|,hormone activity|,9,1,1.07,10,-1.4,0.234,0.9,0.644,0.573,-5,4.9
ENSMUSG00000016541,ATXN10,ataxin 10,extracellular space|cytoplasm|cytosol|plasma membrane|membrane|dendrite|neuronal cell body|perinuclear region of cytoplasm|,nervous system development|cell death|neuron projection development|,protein binding|identical protein binding|,10,-4.5,3.32,9,1.2,0.674,-4.4,0.643,0.573,-9.1,3.9
ENSMUSG00000021537,CETN3,"centrin, EF-hand protein, 3",cytoplasm|centrosome|centriole|photoreceptor connecting cilium|intermediate filament cytoskeleton|,mitotic nuclear division|centrosome cycle|,calcium ion binding|microtubule binding|G-protein beta/gamma-subunit complex binding|,10,1.4,1.12,10,-0.1,0.0212,1,0.641,0.573,-5.2,5.6
ENSMUSG00000037523,MAVS,mitochondrial antiviral signaling protein,mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|peroxisomal membrane|integral component of membrane|mitochondrial membrane|,"positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|positive regulation of defense response to virus by host|signal transduction|viral process|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of protein import into nucleus, translocation|RIG-I signaling pathway|defense response to bacterium|positive regulation of transcription factor import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|innate immune response|positive regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|cellular response to exogenous dsRNA|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of IP-10 production|regulation of peroxisome organization|",signal transducer activity|protein binding|protein kinase binding|CARD domain binding|,0,0,0,1,1.5,0.694,1.5,0.64,0.574,-1.7,3
ENSMUSG00000027998,PLRG1,pleiotropic regulator 1,nucleus|nuclear speck|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|signal transduction|regulation of RNA biosynthetic process|",transcription corepressor activity|signal transducer activity|protein binding|,0,0,0,1,1.5,0.694,1.5,0.64,0.574,-1.7,3
ENSMUSG00000036908,UNC93B1,unc-93 homolog B1 (C. elegans),Golgi membrane|lysosome|endosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|early phagosome|,toll-like receptor signaling pathway|intracellular protein transport|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|innate immune response|defense response to virus|,None,0,0,0,1,1.5,0.694,1.5,0.64,0.574,-1.7,3
ENSMUSG00000025825,ISCU,iron-sulfur cluster assembly enzyme,nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|,nitrogen fixation|iron-sulfur cluster assembly|small molecule metabolic process|,iron ion binding|protein binding|protein complex scaffold|iron-sulfur cluster binding|,0,0,0,1,1.5,0.694,1.5,0.64,0.574,-1.7,3
ENSMUSG00000017499,CDC6,cell division cycle 6,spindle pole|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|spindle midzone|,DNA replication checkpoint|regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|mitotic nuclear division|traversing start control point of mitotic cell cycle|negative regulation of DNA replication|negative regulation of cell proliferation|regulation of mitotic metaphase/anaphase transition|positive regulation of cytokinesis|positive regulation of chromosome segregation|,nucleotide binding|chromatin binding|protein binding|ATP binding|nucleoside-triphosphatase activity|kinase binding|,8,-2.9,0.844,8,0.3,0.0345,-0.9,0.638,0.574,-6.1,2.6
ENSMUSG00000028373,ASTN2,astrotactin 2,endosome|integral component of membrane|cell pole|,negative regulation of protein localization to cell surface|,None,0,0,0,2,-1.5,0.692,-1.5,0.638,0.574,-3,1.7
ENSMUSG00000030166,RAD52,RAD52 homolog (S. cerevisiae),nucleus|nucleoplasm|,double-strand break repair via homologous recombination|DNA recombinase assembly|DNA repair|double-strand break repair|DNA recombination|,DNA binding|protein binding|identical protein binding|,10,-0.7,0.18,10,-0.6,0.516,-0.6,0.637,0.575,-4.1,2.1
ENSMUSG00000062867,IMPDH2,IMP (inosine 5'-monophosphate) dehydrogenase 2,nucleus|cytoplasm|peroxisomal membrane|cytosol|membrane|extracellular vesicular exosome|,purine nucleobase metabolic process|GMP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|small molecule metabolic process|nucleobase-containing small molecule metabolic process|oxidation-reduction process|,nucleotide binding|DNA binding|RNA binding|IMP dehydrogenase activity|adenyl nucleotide binding|metal ion binding|,10,-3,1.52,10,0,0,-0.8,0.635,0.575,-6.6,2.3
ENSMUSG00000005640,INSRR,insulin receptor-related receptor,integral component of plasma membrane|receptor complex|,transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|male sex determination|actin cytoskeleton reorganization|protein autophosphorylation|cellular response to alkalinity|,transmembrane receptor protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|ATP binding|phosphatidylinositol 3-kinase binding|insulin receptor substrate binding|,10,-0.3,0.12,10,-0.7,0.68,-0.6,0.635,0.575,-4.6,2.3
ENSMUSG00000025519,TKTL2,transketolase-like 2,cytoplasm|,metabolic process|,transketolase activity|metal ion binding|,10,0,0,10,-2.1,1.57,-2.1,0.634,0.576,-7.5,2.6
ENSMUSG00000025400,TAC2,tachykinin 2,extracellular region|extracellular vesicular exosome|,tachykinin receptor signaling pathway|neuropeptide signaling pathway|positive regulation of blood pressure|,None,9,-6.1,1.96,10,-2,0.573,-4.6,0.634,0.576,-12,6.3
ENSMUSG00000026605,CENPF,"centromere protein F, 350/400kDa","chromosome, centromeric region|kinetochore|chromatin|spindle pole|condensed chromosome outer kinetochore|condensed chromosome outer kinetochore|nucleus|nuclear envelope|cytoplasm|spindle|cytosol|nuclear matrix|midbody|pronucleus|perinuclear region of cytoplasm|","mitotic G2 phase|G2/M transition of mitotic cell cycle|mitotic M phase|mitotic M phase|mitotic cell cycle|mitotic cell cycle|DNA replication|chromosome segregation|chromosome segregation|mitotic nuclear division|mitotic spindle assembly checkpoint|muscle organ development|cell proliferation|regulation of G2/M transition of mitotic cell cycle|protein transport|protein transport|regulation of striated muscle tissue development|cell differentiation|response to drug|negative regulation of transcription, DNA-templated|metaphase plate congression|kinetochore assembly|regulation of cell cycle|",chromatin binding|protein binding|protein C-terminus binding|transcription factor binding|protein homodimerization activity|dynein binding|,10,0,0,10,1.8,1.72,1.4,0.632,0.576,-2,4.3
ENSMUSG00000022311,CSMD3,CUB and Sushi multiple domains 3,plasma membrane|integral component of membrane|,None,None,10,0,0,10,-0.7,1.25,-0.6,0.63,0.577,-9.4,3.3
ENSMUSG00000049687,FAM109B,"family with sequence similarity 109, member B",early endosome|trans-Golgi network|clathrin-coated vesicle|recycling endosome|,"receptor recycling|endosome organization|retrograde transport, endosome to Golgi|",protein binding|protein homodimerization activity|,1,1.4,0.682,0,0,0,1.4,0.628,0.577,-1.7,4
ENSMUSG00000079105,C7,complement component 7,extracellular region|membrane attack complex|extracellular vesicular exosome|,"cellular sodium ion homeostasis|complement activation|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|regulation of complement activation|innate immune response|",None,9,-1.5,0.582,9,-0.8,0.269,-1.3,0.625,0.578,-6.5,6.3
ENSMUSG00000000600,KRIT1,"KRIT1, ankyrin repeat containing",extracellular space|cytoplasm|microtubule|plasma membrane|cell-cell junction|,angiogenesis|negative regulation of endothelial cell proliferation|small GTPase mediated signal transduction|negative regulation of endothelial cell migration|negative regulation of angiogenesis|positive regulation of protein binding|cell redox homeostasis|regulation of catalytic activity|regulation of establishment of cell polarity|negative regulation of endothelial cell apoptotic process|,"small GTPase regulator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|microtubule binding|protein complex binding|",10,-4.5,2.37,10,-0.6,0.146,-3.4,0.625,0.578,-8.9,1.3
ENSMUSG00000057719,SH3RF2,SH3 domain containing ring finger 2,None,negative regulation of phosphatase activity|protein ubiquitination|,protein phosphatase inhibitor activity|protein binding|protein phosphatase 1 binding|zinc ion binding|ligase activity|phosphatase binding|,1,-1.7,0.673,0,0,0,-1.7,0.621,0.58,-4,1.7
ENSMUSG00000030074,GXYLT2,glucoside xylosyltransferase 2,integral component of membrane|,O-glycan processing|,UDP-xylosyltransferase activity|,1,-1.7,0.673,0,0,0,-1.7,0.621,0.58,-4,1.7
ENSMUSG00000001833,7-Sep,septin 7,condensed chromosome kinetochore|stress fiber|nucleus|nucleolus|cytoplasm|spindle|plasma membrane|axoneme|actin cytoskeleton|microtubule cytoskeleton|apical plasma membrane|midbody|septin complex|cleavage furrow|axon terminus|synapse|extracellular vesicular exosome|,cytokinesis|mitotic nuclear division|regulation of embryonic cell shape|protein heterooligomerization|cilium morphogenesis|,structural molecule activity|protein binding|GTP binding|identical protein binding|,10,-3.2,1.97,10,0.3,0.163,-1,0.619,0.58,-8.6,2
ENSMUSG00000019828,GRM1,"glutamate receptor, metabotropic 1",nucleus|plasma membrane|integral component of plasma membrane|integral component of plasma membrane|postsynaptic density|dendrite|G-protein coupled receptor dimeric complex|G-protein coupled receptor homodimeric complex|,"activation of MAPKK activity|activation of MAPK activity|G-protein coupled receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|synaptic transmission|locomotory behavior|cell death|sensory perception of pain|dimeric G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|regulation of sensory perception of pain|regulation of synaptic transmission, glutamatergic|cellular response to electrical stimulus|",G-protein coupled receptor activity|protein binding|glutamate receptor activity|glutamate receptor activity|,10,1.7,1.19,10,-0.2,0.0239,1.1,0.618,0.58,-2.8,6.6
ENSMUSG00000058571,GPC6,glypican 6,proteinaceous extracellular matrix|extracellular space|nucleus|Golgi lumen|plasma membrane|integral component of plasma membrane|anchored component of membrane|lysosomal lumen|,"retinoid metabolic process|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|phototransduction, visible light|cell migration|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|small molecule metabolic process|",heparan sulfate proteoglycan binding|,10,-0.4,0.285,10,-1.1,0.492,-0.5,0.618,0.58,-4.8,2.1
ENSMUSG00000017004,SVS5,seminal vesicle secretory protein 5,extracellular region|,None,None,1,-1.7,0.667,0,0,0,-1.7,0.615,0.581,-4,1.7
ENSMUSG00000095788,SIRPB1A,signal-regulatory protein beta 1A,intracellular|plasma membrane|extracellular vesicular exosome|,intracellular signal transduction|positive regulation of phagocytosis|,molecular_function|,1,-1.7,0.667,0,0,0,-1.7,0.615,0.581,-4,1.7
ENSMUSG00000055900,TMEM69,transmembrane protein 69,integral component of membrane|,None,None,1,1.7,1,1,-2.1,0.67,1.6,0.615,0.581,-3.6,4
ENSMUSG00000055547,APOBEC4,"apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)",None,mRNA processing|,"zinc ion binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|",10,-3.8,1.6,10,-0.4,0.126,-1.5,0.615,0.581,-6.8,2.6
ENSMUSG00000001036,EPN2,epsin 2,nucleus|Golgi apparatus|clathrin coat of endocytic vesicle|intracellular membrane-bounded organelle|,in utero embryonic development|endocytosis|Notch signaling pathway|embryonic organ development|,lipid binding|,10,-5.6,3.21,10,-0.2,0.0093,-0.8,0.615,0.581,-10.1,1.8
ENSMUSG00000027966,COL11A1,"collagen, type XI, alpha 1",extracellular region|collagen type XI trimer|collagen type XI trimer|endoplasmic reticulum lumen|,cartilage condensation|chondrocyte development|proteoglycan metabolic process|visual perception|sensory perception of sound|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix organization|collagen fibril organization|collagen catabolic process|tendon development|inner ear morphogenesis|embryonic skeletal system morphogenesis|detection of mechanical stimulus involved in sensory perception of sound|ventricular cardiac muscle tissue morphogenesis|,"extracellular matrix structural constituent|protein binding, bridging|metal ion binding|extracellular matrix binding|",10,6.2,3.61,10,0,0,6.1,0.614,0.581,-3.4,13
ENSMUSG00000022496,TNFRSF17,"tumor necrosis factor receptor superfamily, member 17",plasma membrane|endomembrane system|integral component of membrane|,immune system process|signal transduction|multicellular organismal development|cell proliferation|tumor necrosis factor-mediated signaling pathway|,receptor activity|tumor necrosis factor-activated receptor activity|,10,3.6,0.721,10,1,0.617,3.2,0.613,0.582,-5,8.6
ENSMUSG00000067889,SPTBN2,"spectrin, beta, non-erythrocytic 2",extracellular space|cytosol|spectrin|neuronal cell body|,axon guidance|synapse assembly|cell death|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|cerebellar Purkinje cell layer morphogenesis|adult behavior|multicellular organism growth|actin filament capping|,actin binding|structural constituent of cytoskeleton|phospholipid binding|,1,1.4,0.661,0,0,0,1.4,0.609,0.583,-1.7,4
ENSMUSG00000017195,ZPBP2,zona pellucida binding protein 2,acrosomal vesicle|zona pellucida receptor complex|extracellular region|nucleus|cell body|,acrosome assembly|binding of sperm to zona pellucida|,None,0,0,0,1,-2.1,0.661,-2.1,0.609,0.583,-4,1.6
ENSMUSG00000014686,CEACAM16,carcinoembryonic antigen-related cell adhesion molecule 16,extracellular region|stereocilium bundle tip|,sensory perception of sound|,None,1,-1.7,0.66,0,0,0,-1.7,0.608,0.584,-3,1.7
ENSMUSG00000029027,DFFB,"DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)",nuclear chromatin|nucleus|nucleoplasm|cytosol|cytosol|,apoptotic DNA fragmentation|apoptotic DNA fragmentation|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|brain development|apoptotic chromosome condensation|,DNA binding|nicotinate phosphoribosyltransferase activity|deoxyribonuclease activity|enzyme binding|,10,-3.7,0.415,10,-0.5,0.37,-0.5,0.608,0.584,-9.3,1.6
ENSMUSG00000024867,PIP5K1B,"phosphatidylinositol-4-phosphate 5-kinase, type I, beta",uropod|cytosol|endomembrane system|membrane|,phospholipid metabolic process|phosphatidylinositol biosynthetic process|small molecule metabolic process|phosphatidylinositol phosphorylation|phosphatidylinositol phosphorylation|,protein binding|ATP binding|1-phosphatidylinositol-4-phosphate 5-kinase activity|,1,-1.7,0.66,0,0,0,-1.7,0.608,0.584,-3,1.7
ENSMUSG00000031955,BCAR1,breast cancer anti-estrogen resistance 1,ruffle|nucleolus|cytoplasm|cytosol|plasma membrane|plasma membrane|focal adhesion|focal adhesion|lamellipodium|,regulation of cell growth|actin filament organization|cell adhesion|epidermal growth factor receptor signaling pathway|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|blood coagulation|cell proliferation|insulin receptor signaling pathway|positive regulation of endothelial cell migration|cell migration|platelet activation|positive regulation of cell migration|cellular response to hepatocyte growth factor stimulus|regulation of apoptotic process|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|antigen receptor-mediated signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|cell division|cell chemotaxis|,signal transducer activity|protein binding|SH3 domain binding|protein kinase binding|,10,-1.2,0.888,10,2.5,2.15,0.8,0.608,0.584,-6.7,6
ENSMUSG00000027189,TRIM44,tripartite motif containing 44,intracellular|,None,protein binding|zinc ion binding|,0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000026383,EPB4.1L5,erythrocyte protein band 4.1-like 5,nucleus|cytoplasm|cytoskeleton|plasma membrane|plasma membrane|focal adhesion|extrinsic component of membrane|cell junction|cell leading edge|ruffle membrane|,"cell morphogenesis involved in differentiation|in utero embryonic development|somitogenesis|epithelial to mesenchymal transition|neural plate morphogenesis|positive regulation of cell-matrix adhesion|epithelial cell morphogenesis|apical constriction|substrate-dependent cell migration, cell attachment to substrate|ectoderm development|endoderm development|mesoderm development|mesoderm migration involved in gastrulation|unidimensional cell growth|posttranscriptional regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-cell adhesion|actin cytoskeleton organization|actin cytoskeleton organization|actomyosin structure organization|negative regulation of protein binding|positive regulation of protein binding|somite rostral/caudal axis specification|axial mesoderm development|axial mesoderm morphogenesis|paraxial mesoderm development|embryonic foregut morphogenesis|positive regulation of focal adhesion assembly|regulation of establishment of protein localization|left/right axis specification|cellular response to transforming growth factor beta stimulus|",protein binding|cytoskeletal protein binding|protein domain specific binding|,0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000030770,PARVA,"parvin, alpha",cytoplasm|cytosol|plasma membrane|focal adhesion|actin cytoskeleton|Z disc|,sprouting angiogenesis|outflow tract septum morphogenesis|establishment or maintenance of cell polarity|regulation of cell shape|actin cytoskeleton reorganization|heterotypic cell-cell adhesion|cell junction assembly|substrate adhesion-dependent cell spreading|cilium morphogenesis|actin-mediated cell contraction|smooth muscle cell chemotaxis|,actin binding|protein binding|,0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000025971,9430016H08RIK,RIKEN cDNA 9430016H08 gene,cellular_component|mitochondrion|,biological_process|,molecular_function|,0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000022407,ADSL,adenylosuccinate lyase,mitochondrion|cytosol|,response to hypoxia|purine nucleobase metabolic process|purine nucleotide biosynthetic process|AMP biosynthetic process|'de novo' IMP biosynthetic process|response to nutrient|metabolic process|aerobic respiration|purine ribonucleoside monophosphate biosynthetic process|response to muscle activity|response to starvation|'de novo' AMP biosynthetic process|small molecule metabolic process|protein tetramerization|nucleobase-containing small molecule metabolic process|,"N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|",0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000019809,PEX3,peroxisomal biogenesis factor 3,nucleus|peroxisome|peroxisome|peroxisomal membrane|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|cytosol|membrane|protein-lipid complex|intracellular membrane-bounded organelle|protein complex|,peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome membrane|transmembrane transport|,protein binding|lipid binding|protein dimerization activity|,0,0,0,1,1.5,0.656,1.5,0.605,0.584,-1.7,3
ENSMUSG00000050335,LGALS3,"lectin, galactoside-binding, soluble, 3",immunological synapse|proteinaceous extracellular matrix|extracellular space|nucleus|spliceosomal complex|cytoplasm|mitochondrial inner membrane|plasma membrane|membrane|extracellular matrix|extracellular vesicular exosome|,skeletal system development|monocyte chemotaxis|mRNA processing|RNA splicing|extracellular matrix organization|neutrophil chemotaxis|epithelial cell differentiation|regulation of T cell proliferation|innate immune response|negative regulation of endocytosis|eosinophil chemotaxis|macrophage chemotaxis|negative regulation of T cell receptor signaling pathway|positive chemotaxis|regulation of T cell apoptotic process|mononuclear cell migration|positive regulation of mononuclear cell migration|positive regulation of calcium ion import|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of immunological synapse formation|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|negative regulation of extrinsic apoptotic signaling pathway|,protein binding|IgE binding|carbohydrate binding|chemoattractant activity|laminin binding|poly(A) RNA binding|,10,-1.2,1.82,10,0,0,-0.8,0.604,0.585,-12.7,2.6
ENSMUSG00000050836,NTNG1,netrin G1,anchored component of plasma membrane|,axonogenesis|,protein binding|,10,-1.3,0.756,10,-0.6,0.251,-1,0.6,0.586,-4,3.1
ENSMUSG00000028465,TLN1,talin 1,ruffle|extracellular region|cytoplasm|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|focal adhesion|focal adhesion|focal adhesion|cell surface|actin cytoskeleton|ruffle membrane|extracellular vesicular exosome|,platelet degranulation|cellular component movement|muscle contraction|activation of signaling protein activity involved in unfolded protein response|cytoskeletal anchoring at plasma membrane|cell-cell junction assembly|cell-substrate junction assembly|cell adhesion|axon guidance|blood coagulation|platelet activation|cortical actin cytoskeleton organization|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|,actin binding|insulin receptor binding|integrin binding|structural constituent of cytoskeleton|protein binding|vinculin binding|LIM domain binding|,10,0.2,0.0259,10,1.2,1.04,0.8,0.6,0.586,-2.9,4
ENSMUSG00000026656,FCGR2B,"Fc fragment of IgG, low affinity IIb, receptor (CD32)",plasma membrane|integral component of membrane|,immune response|signal transduction|viral process|regulation of immune response|,protein binding|IgG binding|,10,-0.3,0.184,10,-0.7,0.554,-0.5,0.599,0.586,-7.7,2
ENSMUSG00000054555,ADAM12,ADAM metallopeptidase domain 12,extracellular region|plasma membrane|integral component of membrane|,proteolysis|cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|,metalloendopeptidase activity|protein binding|metallopeptidase activity|zinc ion binding|SH3 domain binding|,10,0.1,0.0126,10,0.8,1.22,0.5,0.599,0.586,-1.9,3.5
ENSMUSG00000031824,6430548M08RIK,RIKEN cDNA 6430548M08 gene,cellular_component|,biological_process|,molecular_function|,10,-2.4,1.78,10,-0.2,0.0178,-0.8,0.596,0.587,-8.3,2.8
ENSMUSG00000005994,TYRP1,tyrosinase-related protein 1,endosome membrane|integral component of membrane|clathrin-coated endocytic vesicle membrane|melanosome membrane|melanosome|,melanocyte differentiation|melanosome organization|melanin biosynthetic process|acetoacetic acid metabolic process|oxidation-reduction process|,"copper ion binding|protein binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein homodimerization activity|protein heterodimerization activity|",10,0.4,0.22,10,1.2,0.655,0.6,0.596,0.587,-5.1,6
ENSMUSG00000020023,TMCC3,transmembrane and coiled-coil domain family 3,integral component of membrane|,None,None,1,-1.6,0.647,0,0,0,-1.6,0.596,0.587,-3,1.7
ENSMUSG00000022779,TOP3B,topoisomerase (DNA) III beta,condensed chromosome|nucleus|,DNA topological change|chromosome segregation|,DNA binding|DNA topoisomerase activity|DNA topoisomerase type I activity|poly(A) RNA binding|,10,0.9,0.649,10,0.4,0.0629,0.7,0.594,0.588,-3.7,4
ENSMUSG00000027959,SASS6,spindle assembly 6 homolog (C. elegans),centrosome|centrosome|centriole|deuterosome|,centriole replication|centrosome duplication|,protein binding|,10,0.1,0.00652,10,1.3,0.961,0.6,0.593,0.588,-2.3,4.6
ENSMUSG00000005580,ADCY9,adenylate cyclase 9,plasma membrane|integral component of plasma membrane|axon|dendrite|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|ATP binding|metal ion binding|,10,-0.1,0.00858,10,-5.1,0.689,-0.6,0.591,0.588,-8.6,1.4
ENSMUSG00000024266,ADAD2,adenosine deaminase domain containing 2,None,RNA processing|,RNA binding|adenosine deaminase activity|,1,-1.6,0.639,0,0,0,-1.6,0.589,0.589,-3,1.7
ENSMUSG00000028328,TMOD1,tropomodulin 1,cytosol|COP9 signalosome|membrane|myofibril|cortical cytoskeleton|,adult locomotory behavior|muscle filament sliding|myofibril assembly|,actin binding|tropomyosin binding|,9,0.7,0.463,10,-0.6,0.38,-0.8,0.589,0.589,-5.2,5.6
ENSMUSG00000002580,MIEN1,migration and invasion enhancer 1,cytosol|intrinsic component of the cytoplasmic side of the plasma membrane|extracellular vesicular exosome|,apoptotic process|positive regulation of cell migration|negative regulation of apoptotic process|cell redox homeostasis|positive regulation of filopodium assembly|,selenium binding|,1,-1.6,0.639,0,0,0,-1.6,0.589,0.589,-3,1.7
ENSMUSG00000068234,VMN1R44,vomeronasal 1 receptor 44,cellular_component|plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of chemical stimulus|response to pheromone|,signal transducer activity|receptor activity|G-protein coupled receptor activity|pheromone receptor activity|,0,0,0,1,-2,0.639,-2,0.588,0.589,-4,1.6
ENSMUSG00000045752,TSSC4,tumor suppressing subtransferable candidate 4,None,None,None,0,0,0,1,-2,0.639,-2,0.588,0.589,-4,1.6
ENSMUSG00000043866,TAF10,"TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa",PCAF complex|nucleus|nucleoplasm|transcription factor TFIID complex|cytoplasm|STAGA complex|transcription factor TFTC complex|perinuclear region of cytoplasm|,"chromatin organization|DNA-templated transcription, initiation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|histone deubiquitination|histone H3 acetylation|protein homooligomerization|",sequence-specific DNA binding transcription factor activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|protein binding|enzyme binding|estrogen receptor binding|RNA polymerase binding|,10,-0.6,0.403,9,-0.8,0.258,-0.7,0.586,0.59,-10.1,6.7
ENSMUSG00000029275,GFI1,growth factor independent 1 transcription repressor,nucleus|nuclear matrix|nuclear body|transcriptional repressor complex|,"regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|mechanosensory behavior|negative regulation of cell fate specification|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|negative regulation of neuron projection development|viral process|negative regulation of NF-kappaB transcription factor activity|regulation of toll-like receptor signaling pathway|inner ear morphogenesis|auditory receptor cell differentiation|positive regulation of cell fate specification|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|protein binding|zinc ion binding|transcription regulatory region DNA binding|,10,-1.6,0.823,10,1,0.432,-1.3,0.585,0.59,-4.1,5
ENSMUSG00000060579,FHIT,fragile histidine triad,nucleus|cytoplasm|mitochondrion|cytosol|extracellular vesicular exosome|,"purine nucleotide metabolic process|DNA replication|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleotide metabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intrinsic apoptotic signaling pathway by p53 class mediator|",nucleotide binding|catalytic activity|protein binding|hydrolase activity|ubiquitin protein ligase binding|identical protein binding|bis(5'-adenosyl)-triphosphatase activity|,10,-1.1,0.208,10,-0.7,0.485,-0.9,0.584,0.591,-4.9,2
ENSMUSG00000057777,MAB21L2,mab-21-like 2 (C. elegans),nucleus|,nervous system development|positive regulation of cell proliferation|embryonic body morphogenesis|camera-type eye development|,None,10,-2.4,1.82,10,0,0,-0.9,0.582,0.591,-5.5,3.5
ENSMUSG00000063605,CCDC102A,coiled-coil domain containing 102A,None,None,None,1,-1.5,0.631,0,0,0,-1.5,0.582,0.591,-3,1.7
ENSMUSG00000036023,PARP2,poly (ADP-ribose) polymerase 2,nucleus|nucleoplasm|nucleolus|,DNA repair|base-excision repair|protein ADP-ribosylation|extrinsic apoptotic signaling pathway|,DNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|,10,-1,0.819,10,-0.3,0.0664,-0.8,0.577,0.593,-4.7,2.1
ENSMUSG00000071517,GM10334,predicted gene 10334,cellular_component|,proteolysis|biological_process|,molecular_function|peptidase activity|serine-type peptidase activity|hydrolase activity|,4,0,0,4,-1.6,1.23,-0.6,0.572,0.595,-5.7,1.5
ENSMUSG00000026098,PMS1,PMS1 postmeiotic segregation increased 1 (S. cerevisiae),nucleus|MutLalpha complex|,ATP catabolic process|mismatch repair|response to drug|,DNA binding|single-stranded DNA binding|ATP binding|ATPase activity|mismatched DNA binding|,10,-0.9,0.121,10,-1.5,0.708,-1.3,0.571,0.595,-6.3,2.7
ENSMUSG00000031928,MRE11A,MRE11 meiotic recombination 11 homolog A (S. cerevisiae),"chromosome, telomeric region|chromatin|nucleus|nucleoplasm|cytosol|Mre11 complex|Mre11 complex|site of double-strand break|","regulation of mitotic recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|DNA repair|base-excision repair|nucleotide-excision repair|double-strand break repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|sister chromatid cohesion|mitotic G2 DNA damage checkpoint|synapsis|reciprocal meiotic recombination|cell proliferation|intra-S DNA damage checkpoint|positive regulation of protein autophosphorylation|positive regulation of type I interferon production|DNA duplex unwinding|negative regulation of DNA endoreduplication|positive regulation of kinase activity|innate immune response|nucleic acid phosphodiester bond hydrolysis|nucleic acid phosphodiester bond hydrolysis|",single-stranded DNA endodeoxyribonuclease activity|DNA binding|double-stranded DNA binding|ATP-dependent DNA helicase activity|nuclease activity|endonuclease activity|endodeoxyribonuclease activity|protein binding|protein C-terminus binding|3'-5' exonuclease activity|manganese ion binding|,10,2.7,3.37,10,-0.9,1.64,2.4,0.57,0.595,-7.9,6.9
ENSMUSG00000059042,KLK1B9,kallikrein 1-related peptidase b9,nucleus|,proteolysis|zymogen activation|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,9,-4.4,2.7,9,0.5,0.121,-1.2,0.57,0.595,-8.8,2.8
ENSMUSG00000032118,FEZ1,fasciculation and elongation protein zeta 1 (zygin I),cytoplasm|centrosome|microtubule|plasma membrane|microtubule cytoskeleton|axon|dendrite|,transport|cell adhesion|nervous system development|axon guidance|positive regulation of neuron projection development|positive regulation of neuron differentiation|establishment of mitochondrion localization|cellular response to growth factor stimulus|,protein kinase C binding|protein binding|gamma-tubulin binding|protein N-terminus binding|,9,3,0.137,9,-1.8,1.66,-1.6,0.569,0.596,-5.3,6.7
ENSMUSG00000066129,KNDC1,kinase non-catalytic C-lobe domain (KIND) containing 1,cellular_component|dendrite|guanyl-nucleotide exchange factor complex|neuronal cell body|,positive regulation of protein phosphorylation|protein phosphorylation|small GTPase mediated signal transduction|biological_process|cerebellar granule cell differentiation|positive regulation of Ras GTPase activity|regulation of dendrite morphogenesis|,molecular_function|protein serine/threonine kinase activity|Ras guanyl-nucleotide exchange factor activity|,9,-1,1.59,9,0,0,-0.7,0.569,0.596,-2.8,1.3
ENSMUSG00000021711,TRAPPC13,trafficking protein particle complex 13,None,None,protein binding|,0,0,0,1,-2,0.617,-2,0.568,0.596,-4,1.7
ENSMUSG00000043855,OLFR479,olfactory receptor 479,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,0,0,0,1,-2,0.617,-2,0.568,0.596,-4,1.7
ENSMUSG00000050105,GRRP1,glycine/arginine rich protein 1,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-2,0.617,-2,0.568,0.596,-4,1.7
ENSMUSG00000035158,MITF,microphthalmia-associated transcription factor,nucleus|protein complex|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein complex assembly|osteoclast differentiation|melanocyte differentiation|regulation of cell proliferation|camera-type eye development|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|cell fate commitment|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|bone remodeling|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|protein dimerization activity|,10,0.6,0.236,10,1.7,0.758,0.8,0.568,0.596,-8.7,5
ENSMUSG00000078960,TOB2,"transducer of ERBB2, 2",nucleus|cytoplasm|,female gamete generation|negative regulation of cell proliferation|regulation of gene expression|negative regulation of osteoclast differentiation|positive regulation of ossification|,protein binding|vitamin D receptor binding|,0,0,0,1,-2,0.617,-2,0.568,0.596,-4,1.7
ENSMUSG00000045100,SLC25A26,"solute carrier family 25 (S-adenosylmethionine carrier), member 26",mitochondrion|mitochondrial inner membrane|integral component of membrane|,S-adenosyl-L-methionine transport|S-adenosyl-L-methionine transmembrane transport|,S-adenosyl-L-methionine transmembrane transporter activity|,0,0,0,1,1.4,0.616,1.4,0.567,0.596,-1.7,3
ENSMUSG00000020961,STON2,stonin 2,nucleolus|cytoplasm|synaptic vesicle|cell junction|clathrin adaptor complex|clathrin-coated vesicle|neuron projection|,intracellular protein transport|regulation of endocytosis|synaptic vesicle endocytosis|,protein binding|,0,0,0,1,1.4,0.616,1.4,0.567,0.596,-1.7,3
ENSMUSG00000026792,LRSAM1,leucine rich repeat and sterile alpha motif containing 1,extracellular region|cytoplasm|membrane|,protein polyubiquitination|cell death|protein catabolic process|negative regulation of endocytosis|viral budding|protein autoubiquitination|ubiquitin-dependent endocytosis|,ubiquitin-protein transferase activity|hormone activity|protein binding|zinc ion binding|ligase activity|,0,0,0,1,1.4,0.616,1.4,0.567,0.596,-1.7,3
ENSMUSG00000064036,MRO,maestro,nucleolus|,None,None,0,0,0,1,1.4,0.616,1.4,0.567,0.596,-1.7,3
ENSMUSG00000044066,CEP68,centrosomal protein 68kDa,cytoplasm|centrosome|,centriole-centriole cohesion|protein localization to organelle|centrosome organization|,protein kinase binding|protein domain specific binding|,10,-1.6,0.37,10,-1.7,0.252,-1.7,0.567,0.596,-6.6,3.8
ENSMUSG00000048251,BCL11B,B-cell CLL/lymphoma 11B (zinc finger protein),nucleus|,"keratinocyte development|epithelial cell morphogenesis|transcription, DNA-templated|negative regulation of cell proliferation|regulation of keratinocyte proliferation|regulation of lipid metabolic process|striatal medium spiny neuron differentiation|post-embryonic camera-type eye development|T cell differentiation in thymus|T cell receptor V(D)J recombination|odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|positive T cell selection|regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|alpha-beta T cell differentiation|thymus development|olfactory bulb axon guidance|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protein binding|metal ion binding|,10,0,0,10,-0.9,0.755,-0.9,0.567,0.596,-4.1,1.5
ENSMUSG00000032498,MLH1,mutL homolog 1,synaptonemal complex|male germ cell nucleus|nucleus|nucleus|chiasma|membrane|MutLalpha complex|,nuclear-transcribed mRNA poly(A) tail shortening|resolution of meiotic recombination intermediates|ATP catabolic process|mismatch repair|double-strand break repair via nonhomologous end joining|male meiosis chromosome segregation|synapsis|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|somatic hypermutation of immunoglobulin genes|meiotic metaphase I plate congression|isotype switching|negative regulation of mitotic recombination|oogenesis|spindle midzone assembly involved in meiosis|,single-stranded DNA binding|protein binding|protein binding|ATP binding|ATPase activity|guanine/thymine mispair binding|MutSalpha complex binding|,10,3.8,0.879,10,0.7,0.297,0.9,0.566,0.596,-4.8,8.7
ENSMUSG00000029722,AGFG2,ArfGAP with FG repeats 2,cellular_component|membrane|,biological_process|regulation of ARF GTPase activity|positive regulation of GTPase activity|,molecular_function|ARF GTPase activator activity|zinc ion binding|,10,-0.8,0.373,10,-1,0.276,-0.8,0.565,0.597,-4.7,3
ENSMUSG00000031880,RRAD,Ras-related associated with diabetes,plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|,GTPase activity|protein binding|calmodulin binding|GTP binding|,10,0,0,10,-1.3,0.924,-0.6,0.565,0.597,-8.2,2
ENSMUSG00000042508,DMTF1,cyclin D binding myb-like transcription factor 1,nucleus|nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|",DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|,10,0.7,0.301,10,1.2,0.371,0.9,0.563,0.597,-2.4,3.7
ENSMUSG00000031864,INTS10,integrator complex subunit 10,integrator complex|,snRNA processing|,protein binding|protein binding|,1,1.3,0.612,0,0,0,1.3,0.563,0.597,-1.7,4
ENSMUSG00000042104,UGGT2,UDP-glucose glycoprotein glucosyltransferase 2,endoplasmic reticulum lumen|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|,protein folding|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|UDP-glucosylation|UDP-glucosylation|,UDP-glucose:glycoprotein glucosyltransferase activity|,10,-2.6,1.72,10,-0.4,0.19,-1.9,0.561,0.598,-7.2,2
ENSMUSG00000038765,LMX1B,"LIM homeobox transcription factor 1, beta",nucleus|,"in utero embryonic development|neuron migration|trabecular meshwork development|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|cell death|cell proliferation|dorsal/ventral pattern formation|cerebellum morphogenesis|central nervous system neuron development|neuron differentiation|collagen fibril organization|midbrain development|limb morphogenesis|organ growth|positive regulation of transcription from RNA polymerase II promoter|dopaminergic neuron differentiation|",sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|,1,-2.3,0.878,1,-0.4,0.0457,-2.1,0.561,0.598,-5,1.5
ENSMUSG00000023826,PARK2,parkin RBR E3 ubiquitin protein ligase,ubiquitin ligase complex|nucleus|cytoplasm|mitochondrion|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|aggresome|perinuclear region of cytoplasm|,"protein polyubiquitination|mitochondrion degradation|negative regulation of protein phosphorylation|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|central nervous system development|cell death|regulation of autophagy|protein ubiquitination|negative regulation of actin filament bundle assembly|negative regulation of glucokinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of neuron apoptotic process|cellular protein catabolic process|negative regulation of insulin secretion|protein autoubiquitination|negative regulation of cell death|protein K63-linked ubiquitination|aggresome assembly|protein K48-linked ubiquitination|neuron death|negative regulation of release of cytochrome c from mitochondria|negative regulation of neuron death|regulation of reactive oxygen species metabolic process|",ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|kinase binding|protein kinase binding|PDZ domain binding|ubiquitin protein ligase binding|identical protein binding|ubiquitin binding|chaperone binding|ubiquitin protein ligase activity|ubiquitin-specific protease binding|,10,0.4,0.114,10,0.8,0.6,0.5,0.561,0.598,-2.6,2.9
ENSMUSG00000042129,RASSF4,Ras association (RalGDS/AF-6) domain family member 4,None,cell cycle|signal transduction|,protein binding|,10,1.2,1.3,10,0.1,0.0159,0.6,0.56,0.599,-3.3,3.7
ENSMUSG00000020962,GTF2A1,"general transcription factor IIA, 1, 19/37kDa",nucleus|nucleoplasm|transcription factor TFIIA complex|cytoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|",DNA binding|transcription coactivator activity|protein binding|transcription factor binding|TBP-class protein binding|protein heterodimerization activity|,1,0,0,2,-2.1,0.915,-1.3,0.559,0.599,-4,1.5
ENSMUSG00000020167,TCF3,transcription factor 3,nuclear nucleosome|nuclear chromatin|nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|natural killer cell differentiation|B cell lineage commitment|B cell lineage commitment|transcription, DNA-templated|regulation of transcription, DNA-templated|B cell differentiation|positive regulation of B cell proliferation|response to lipopolysaccharide|T cell differentiation in thymus|immunoglobulin V(D)J recombination|response to drug|muscle cell differentiation|histone H3 acetylation|histone H4 acetylation|positive regulation of neuron differentiation|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|cell development|Peyer's patch development|protein stabilization|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of muscle cell differentiation|regulation of G1/S transition of mitotic cell cycle|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding|DNA binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|mitogen-activated protein kinase kinase kinase binding|enhancer binding|protein homodimerization activity|bHLH transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|protein heterodimerization activity|protein heterodimerization activity|repressing transcription factor binding|vitamin D response element binding|E-box binding|E-box binding|E-box binding|,10,-3.1,2.55,10,0.1,0.0249,-0.8,0.559,0.599,-6.3,1.4
ENSMUSG00000026192,ATIC,5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase,mitochondrion|cytosol|membrane|extracellular vesicular exosome|,brainstem development|nucleobase-containing compound metabolic process|purine nucleobase metabolic process|'de novo' IMP biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to inorganic substance|cerebellum development|cerebral cortex development|organ regeneration|small molecule metabolic process|dihydrofolate metabolic process|tetrahydrofolate biosynthetic process|nucleobase-containing small molecule metabolic process|,IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity|,10,-3.3,1.63,9,-0.4,0.209,-0.7,0.558,0.599,-9,2.3
ENSMUSG00000022306,ZFPM2,"zinc finger protein, FOG family member 2",nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|in utero embryonic development|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|transcription, DNA-templated|blood coagulation|lung development|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic organ development|ventricular septum morphogenesis|negative regulation of cell death|positive regulation of male gonad development|negative regulation of female gonad development|",nucleic acid binding transcription factor activity|RNA polymerase II transcription coactivator activity|DNA binding|transcription corepressor activity|protein binding|transcription factor binding|zinc ion binding|,10,-1.1,0.164,10,-0.8,0.505,-0.9,0.555,0.6,-3.5,1.2
ENSMUSG00000004018,FANCL,"Fanconi anemia, complementation group L",nuclear envelope|nucleoplasm|cytoplasm|Fanconi anaemia nuclear complex|,DNA repair|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|gamete generation|regulation of cell proliferation|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|zinc ion binding|ligase activity|ubiquitin protein ligase binding|,9,-0.2,0.0264,10,-0.7,0.689,-0.5,0.552,0.601,-5.8,2.7
ENSMUSG00000072235,TUBA1A,"tubulin, alpha 1a",nucleus|cytosol|microtubule|microtubule|cytoplasmic microtubule|cytoplasmic ribonucleoprotein granule|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|GTP catabolic process|protein folding|microtubule-based process|cytoskeleton-dependent intracellular transport|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|cell division|,GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|protein domain specific binding|,3,-1.3,0.0595,5,-3.9,0.908,-2,0.549,0.602,-8,4.4
ENSMUSG00000005897,NR2C1,"nuclear receptor subfamily 2, group C, member 1",nucleoplasm|PML body|,negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|gene expression|steroid hormone mediated signaling pathway|positive regulation of retinoic acid receptor signaling pathway|,DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|receptor activity|protein binding|zinc ion binding|protein homodimerization activity|histone deacetylase binding|sequence-specific DNA binding|,10,0.1,4.11E-05,10,1.2,0.916,0.8,0.549,0.602,-3.3,5.6
ENSMUSG00000051147,NAT2,N-acetyltransferase 2 (arylamine N-acetyltransferase),cytosol|,xenobiotic metabolic process|small molecule metabolic process|,arylamine N-acetyltransferase activity|,10,-2.6,0.897,9,-0.4,0.129,-0.8,0.548,0.603,-5.7,4
ENSMUSG00000030271,OGG1,8-oxoguanine DNA glycosylase,nucleus|nucleoplasm|nucleoplasm|mitochondrion|nuclear matrix|nuclear speck|,"DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|acute inflammatory response|DNA repair|base-excision repair|base-excision repair, AP site formation|nucleotide-excision repair|regulation of transcription, DNA-templated|response to oxidative stress|response to radiation|response to estradiol|regulation of protein import into nucleus, translocation|response to drug|depurination|response to ethanol|response to folic acid|cellular response to cadmium ion|nucleic acid phosphodiester bond hydrolysis|","damaged DNA binding|endonuclease activity|protein binding|microtubule binding|oxidized purine nucleobase lesion DNA N-glycosylase activity|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|",10,-1.6,0.103,10,-0.9,0.567,-1.2,0.547,0.603,-4.7,6.4
ENSMUSG00000036160,SURF6,surfeit 6,granular component|nucleoplasm|nucleolus|,ribosome biogenesis|,DNA binding|RNA binding|poly(A) RNA binding|,0,0,0,1,-2,0.594,-2,0.547,0.603,-4,1.7
ENSMUSG00000030750,NSMCE1,non-SMC element 1 homolog (S. cerevisiae),"chromosome, telomeric region|nucleus|cytoplasm|Smc5-Smc6 complex|intracellular membrane-bounded organelle|",DNA repair|DNA recombination|protein ubiquitination|intracellular signal transduction|positive regulation of response to DNA damage stimulus|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|,9,-4,1.45,7,1.8,0.843,-1.7,0.546,0.603,-7.8,3.6
ENSMUSG00000034771,TLE2,transducin-like enhancer of split 2,extracellular space|nucleus|nucleoplasm|,"transcription, DNA-templated|signal transduction|Notch signaling pathway|organ morphogenesis|Wnt signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|",transcription corepressor activity|protein binding|,10,0,0,10,-0.9,1.41,-0.6,0.546,0.603,-8.5,2
ENSMUSG00000062075,LMNB2,lamin B2,nuclear inner membrane|lamin filament|,biological_process|,molecular_function|structural molecule activity|,10,-2.6,2.21,10,0.6,0.143,-1.5,0.545,0.604,-7.8,3.5
ENSMUSG00000030650,TMC5,transmembrane channel-like 5,integral component of membrane|,ion transport|,None,1,-1.3,0.575,1,-0.7,0.101,-1.1,0.545,0.604,-3,1.7
ENSMUSG00000023170,GPS2,G protein pathway suppressor 2,nucleus|transcriptional repressor complex|,negative regulation of transcription from RNA polymerase II promoter|inactivation of MAPK activity|cell cycle|JNK cascade|negative regulation of JNK cascade|,transcription corepressor activity|GTPase inhibitor activity|protein binding|,10,-1.1,0.589,10,-0.4,0.198,-0.6,0.544,0.604,-4.1,2.8
ENSMUSG00000040723,RCSD1,RCSD domain containing 1,actin filament|,skeletal muscle contraction|cellular hyperosmotic response|,actin filament binding|,10,1.3,1.01,10,-0.6,0.6,-0.6,0.544,0.604,-5,4.9
ENSMUSG00000053024,CNTN2,contactin 2 (axonal),plasma membrane|integral component of plasma membrane|voltage-gated potassium channel complex|cell surface|anchored component of membrane|node of Ranvier|neuronal cell body|myelin sheath|juxtaparanode region of axon|synapse|,microtubule cytoskeleton organization|cell adhesion|axon guidance|axonal fasciculation|learning|adult walking behavior|positive regulation of protein processing|cerebral cortex GABAergic interneuron migration|central nervous system myelination|regulation of axon diameter|receptor internalization|cellular protein localization|clustering of voltage-gated potassium channels|negative regulation of neuron differentiation|regulation of neuronal synaptic plasticity|regulation of astrocyte differentiation|positive regulation of adenosine receptor signaling pathway|establishment of protein localization to juxtaparanode region of axon|presynaptic membrane organization|,glycoprotein binding|carbohydrate binding|identical protein binding|protein self-association|,10,0.3,0.0568,10,-0.7,0.821,-0.6,0.539,0.606,-4.4,4.8
ENSMUSG00000000381,WAP,whey acidic protein,extracellular region|,negative regulation of peptidase activity|,peptidase inhibitor activity|nutrient reservoir activity|,10,-0.1,0.0203,10,-0.5,0.682,-0.4,0.538,0.606,-8.5,2
ENSMUSG00000031549,IDO2,"indoleamine 2,3-dioxygenase 2",cytoplasm|cytosol|,tryptophan catabolic process|tryptophan catabolic process to kynurenine|tryptophan catabolic process to kynurenine|tryptophan catabolic process to kynurenine|cellular nitrogen compound metabolic process|small molecule metabolic process|oxidation-reduction process|,"tryptophan 2,3-dioxygenase activity|heme binding|indoleamine 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity|metal ion binding|",10,-4.8,2.26,10,1.1,0.677,-1,0.536,0.607,-8.6,3.1
ENSMUSG00000073608,GM6086,predicted gene 6086,cellular_component|,None,None,1,1.6,0.903,1,-0.8,0.104,1.5,0.534,0.607,-1.7,4
ENSMUSG00000000266,MID2,midline 2,cytoplasm|microtubule|microtubule|extracellular vesicular exosome|,protein ubiquitination|negative regulation of viral transcription|protein localization to microtubule|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of viral entry into host cell|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|negative regulation of viral release from host cell|,microtubule binding|zinc ion binding|ligase activity|protein homodimerization activity|protein heterodimerization activity|phosphoprotein binding|,10,5.2,0.713,9,2.3,2,2.3,0.534,0.607,-6,10.9
ENSMUSG00000015222,MAP2,microtubule-associated protein 2,cytoplasm|microtubule|microtubule associated complex|nuclear periphery|neuronal cell body|dendritic shaft|,microtubule bundle formation|axonogenesis|peptidyl-threonine phosphorylation|central nervous system neuron development|neuron projection development|dendrite morphogenesis|cellular response to organic substance|,dystroglycan binding|structural molecule activity|protein binding|calmodulin binding|microtubule binding|,10,1.1,0.642,10,0.3,0.0838,0.7,0.531,0.609,-3.2,3.9
ENSMUSG00000047517,DMBT1,deleted in malignant brain tumors 1,extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|extrinsic component of membrane|phagocytic vesicle membrane|zymogen granule membrane|extracellular vesicular exosome|,inner cell mass cell proliferation|pattern recognition receptor signaling pathway|receptor-mediated endocytosis|receptor-mediated endocytosis|receptor-mediated endocytosis|protein transport|viral process|epithelial cell differentiation|epithelial cell differentiation|positive regulation of epithelial cell differentiation|induction of bacterial agglutination|innate immune response|defense response to virus|,scavenger receptor activity|scavenger receptor activity|protein binding|signaling pattern recognition receptor activity|zymogen binding|calcium-dependent protein binding|,10,-2.6,0.362,10,-0.4,0.313,-0.6,0.53,0.609,-7,2.9
ENSMUSG00000009112,BCL2L13,BCL2-like 13 (apoptosis facilitator),nucleus|mitochondrion|integral component of membrane|mitochondrial membrane|,apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|,cysteine-type endopeptidase activator activity involved in apoptotic process|,10,-2.7,1.45,10,-0.2,0.0553,-2.7,0.53,0.609,-7.8,3.3
ENSMUSG00000026784,PDSS1,"prenyl (decaprenyl) diphosphate synthase, subunit 1",mitochondrial matrix|,ubiquinone biosynthetic process|ubiquinone biosynthetic process|ubiquinone biosynthetic process|isoprenoid biosynthetic process|small molecule metabolic process|protein heterotetramerization|,trans-hexaprenyltranstransferase activity|metal ion binding|protein heterodimerization activity|trans-octaprenyltranstransferase activity|,0,0,0,1,1.4,0.575,1.4,0.529,0.609,-1.7,3
ENSMUSG00000026155,SMAP1,small ArfGAP 1,cytoplasm|plasma membrane|,regulation of ARF GTPase activity|positive regulation of GTPase activity|positive regulation of erythrocyte differentiation|regulation of clathrin-mediated endocytosis|,ARF GTPase activator activity|zinc ion binding|clathrin binding|,0,0,0,1,1.4,0.575,1.4,0.529,0.609,-1.7,3
ENSMUSG00000024829,MRPL21,mitochondrial ribosomal protein L21,mitochondrion|ribosome|,translation|,structural constituent of ribosome|poly(A) RNA binding|,0,0,0,1,1.4,0.575,1.4,0.529,0.609,-1.7,3
ENSMUSG00000019803,NR2E1,"nuclear receptor subfamily 2, group E, member 1",nucleoplasm|,negative regulation of transcription from RNA polymerase II promoter|behavioral fear response|aggressive behavior|transcription initiation from RNA polymerase II promoter|nervous system development|visual perception|glial cell migration|gene expression|dentate gyrus development|amygdala development|olfactory bulb development|layer formation in cerebral cortex|forebrain generation of neurons|cerebral cortex neuron differentiation|anterior commissure morphogenesis|extracellular matrix organization|somatic stem cell maintenance|social behavior|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|cell fate commitment|negative regulation of neuron differentiation|positive regulation of angiogenesis|positive regulation of cell cycle|positive regulation of transcription from RNA polymerase II promoter|negative regulation of astrocyte differentiation|regulation of dendrite morphogenesis|retina development in camera-type eye|regulation of timing of neuron differentiation|long-term synaptic potentiation|regulation of cell migration involved in sprouting angiogenesis|negative regulation of neural precursor cell proliferation|positive regulation of neural precursor cell proliferation|positive regulation of stem cell proliferation|,RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|steroid hormone receptor activity|zinc ion binding|histone deacetylase binding|sequence-specific DNA binding|,10,-1.3,0.925,10,-2,0.112,-1.6,0.529,0.609,-6,3.9
ENSMUSG00000007122,CASQ1,"calsequestrin 1 (fast-twitch, skeletal muscle)",mitochondrion|mitochondrial matrix|endoplasmic reticulum|smooth endoplasmic reticulum|Golgi apparatus|terminal cisterna lumen|T-tubule|I band|sarcoplasmic reticulum membrane|,endoplasmic reticulum organization|skeletal muscle tissue development|response to heat|response to organic substance|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|response to denervation involved in regulation of muscle adaptation|ion transmembrane transport|regulation of sequestering of calcium ion|transmembrane transport|,calcium ion binding|,0,0,0,1,1.4,0.575,1.4,0.529,0.609,-1.7,3
ENSMUSG00000036938,TRY5,trypsin 5,extracellular space|extracellular vesicular exosome|,proteolysis|,serine-type endopeptidase activity|calcium ion binding|peptidase activity|serine-type peptidase activity|hydrolase activity|,1,1,0.367,1,0.8,0.221,0.9,0.529,0.609,-1.7,3
ENSMUSG00000004071,CDIP1,cell death-inducing p53 target 1,nucleus|nucleus|,apoptotic process|tumor necrosis factor-mediated signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|,molecular_function|,10,1.1,0.854,10,-0.1,0.0251,1.1,0.529,0.609,-2.8,7.1
ENSMUSG00000039783,KMO,kynurenine 3-monooxygenase (kynurenine 3-hydroxylase),mitochondrial outer membrane|mitochondrial inner membrane|cytosol|integral component of membrane|extracellular vesicular exosome|,tryptophan catabolic process|response to salt stress|tryptophan catabolic process to kynurenine|quinolinate biosynthetic process|'de novo' NAD biosynthetic process from tryptophan|cellular nitrogen compound metabolic process|anthranilate metabolic process|small molecule metabolic process|oxidation-reduction process|kynurenine metabolic process|,kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity|flavin adenine dinucleotide binding|,0,0,0,1,1.4,0.575,1.4,0.529,0.609,-1.7,3
ENSMUSG00000021957,TKT,transketolase,nucleus|peroxisome|cytosol|extracellular vesicular exosome|,"carbohydrate metabolic process|xylulose biosynthetic process|pentose-phosphate shunt|energy reserve metabolic process|pentose-phosphate shunt, non-oxidative branch|regulation of growth|small molecule metabolic process|glyceraldehyde-3-phosphate biosynthetic process|",transketolase activity|transketolase activity|protein homodimerization activity|metal ion binding|cofactor binding|,10,-2.5,1.83,10,-0.4,0.0704,-2.1,0.526,0.61,-7.7,3.5
ENSMUSG00000094091,GM21885,N/A,None,None,None,0,0,0,1,-1.9,0.572,-1.9,0.526,0.61,-4,1.7
ENSMUSG00000072258,TAF1A,"TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa",RNA polymerase I transcription factor complex|nucleus|nucleoplasm|microtubule cytoskeleton|intracellular membrane-bounded organelle|,"regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|gene expression|",DNA binding|protein binding|,10,-5.1,0.53,10,-1,0.98,-1.1,0.525,0.61,-8.7,1.5
ENSMUSG00000050069,GREM2,"gremlin 2, DAN family BMP antagonist",extracellular region|extracellular space|,embryonic body morphogenesis|cytokine-mediated signaling pathway|BMP signaling pathway|regulation of cytokine activity|,cytokine activity|heparin binding|,10,0.6,0.345,10,-2.1,1.2,-0.9,0.524,0.611,-5.1,2.6
ENSMUSG00000079434,NEU2,sialidase 2 (cytosolic sialidase),cytoplasm|cytosol|,sphingolipid metabolic process|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|small molecule metabolic process|,exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|,10,-3.7,1.53,10,-1,0.759,-1.2,0.521,0.611,-9,1.9
ENSMUSG00000022148,FYB,FYN binding protein,nucleus|cytosol|actin cytoskeleton|,protein phosphorylation|NLS-bearing protein import into nucleus|immune response|signal transduction|biological_process|intracellular signal transduction|T cell receptor signaling pathway|,receptor binding|protein binding|protein complex binding|,10,1.6,1.67,10,-0.8,0.537,-0.6,0.52,0.612,-9.1,5.4
ENSMUSG00000031028,TUB,tubby bipartite transcription factor,extracellular region|nucleus|cytoplasm|cytosol|plasma membrane|,phagocytosis|phototransduction|sensory perception of sound|detection of visible light|response to hormone|multicellular organismal macromolecule metabolic process|positive regulation of phagocytosis|retina development in camera-type eye|,G-protein coupled photoreceptor activity|protein complex binding|,10,0.7,0.419,10,-0.7,0.766,-0.5,0.519,0.612,-4,3
ENSMUSG00000032011,THY1,Thy-1 cell surface antigen,endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|external side of plasma membrane|apical plasma membrane|dendrite|growth cone|anchored component of external side of plasma membrane|membrane raft|extracellular vesicular exosome|,angiogenesis|negative regulation of protein kinase activity|cytoskeleton organization|single organismal cell-cell adhesion|negative regulation of cell migration|positive regulation of Rho GTPase activity|positive regulation of GTPase activity|retinal cone cell development|focal adhesion assembly|negative regulation of axonogenesis|T cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|positive regulation of T cell activation|positive regulation of release of sequestered calcium ion into cytosol|,Rho GTPase activator activity|integrin binding|protein binding|protein kinase binding|GPI anchor binding|,10,-0.9,0.22,10,1.2,1.56,0.7,0.518,0.613,-3.5,4.2
ENSMUSG00000073407,GM6034,predicted gene 6034,cellular_component|,biological_process|,molecular_function|,1,-0.4,0.0795,1,-2.1,0.724,-2,0.518,0.613,-4,1.6
ENSMUSG00000030660,PIK3C2A,"phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha",nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|membrane|clathrin-coated vesicle|vesicle|extracellular vesicular exosome|,phospholipid metabolic process|phosphatidylinositol biosynthetic process|exocytosis|endocytosis|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|vascular smooth muscle contraction|phosphatidylinositol-3-phosphate biosynthetic process|small molecule metabolic process|phosphatidylinositol phosphorylation|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|clathrin coat assembly|,ATP binding|1-phosphatidylinositol-3-kinase activity|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|,1,-1.3,0.562,0,0,0,-1.3,0.517,0.613,-3,1.7
ENSMUSG00000019850,TNFAIP3,"tumor necrosis factor, alpha-induced protein 3",nucleus|cytoplasm|lysosome|centrosome|cytosol|extracellular vesicular exosome|,"B-1 B cell homeostasis|response to molecule of bacterial origin|regulation of germinal center formation|negative regulation of chronic inflammatory response|proteolysis|apoptotic process|inflammatory response|protein deubiquitination|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|response to muramyl dipeptide|negative regulation of interleukin-1 beta production|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 5 signaling pathway|protein K11-linked deubiquitination|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of bone resorption|negative regulation of innate immune response|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|negative regulation of inflammatory response|negative regulation of B cell activation|protein oligomerization|regulation of vascular wound healing|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|protein K63-linked deubiquitination|protein K48-linked ubiquitination|protein K48-linked deubiquitination|cellular response to lipopolysaccharide|tolerance induction to lipopolysaccharide|negative regulation of osteoclast proliferation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of hepatocyte proliferation|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptotic process|",protease binding|DNA binding|ubiquitin thiolesterase activity|ubiquitin-protein transferase activity|ubiquitin-specific protease activity|ubiquitin-specific protease activity|protein binding|zinc ion binding|ligase activity|kinase binding|ubiquitin binding|protein self-association|,10,-0.4,0.117,10,1.6,1.24,0.7,0.515,0.613,-5.8,6.5
ENSMUSG00000026110,MGAT4A,"mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",Golgi membrane|integral component of membrane|extracellular vesicular exosome|,N-glycan processing|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,"alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding|",10,-0.9,0.199,10,-2.5,0.718,-1.4,0.514,0.614,-6.5,4.3
ENSMUSG00000024943,SMC5,structural maintenance of chromosomes 5,"chromosome, telomeric region|nucleus|nucleus|PML body|cell junction|Smc5-Smc6 complex|",telomere maintenance via recombination|double-strand break repair via homologous recombination|mitotic nuclear division|positive regulation of maintenance of mitotic sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|cellular senescence|,protein binding|ATP binding|,10,-0.7,0.46,10,-0.4,0.115,-0.6,0.514,0.614,-3.9,1.6
ENSMUSG00000024346,PFDN1,prefoldin subunit 1,prefoldin complex|,"regulation of transcription, DNA-templated|protein folding|cell cycle|telencephalon development|cerebellum development|actin cytoskeleton organization|B cell activation|cellular protein metabolic process|'de novo' posttranslational protein folding|",sequence-specific DNA binding transcription factor activity|unfolded protein binding|,10,-0.7,0.592,10,-0.3,0.0955,-0.5,0.514,0.614,-4.5,3.1
ENSMUSG00000024400,WDR33,WD repeat domain 33,collagen trimer|nucleus|,postreplication repair|mRNA processing|spermatogenesis|,poly(A) RNA binding|,8,-2.2,1.12,7,1.1,0.688,-2.6,0.511,0.615,-8.2,4.9
ENSMUSG00000061665,CD2AP,CD2-associated protein,ruffle|cytoplasm|plasma membrane|actin cytoskeleton|endocytic vesicle|filamentous actin|perinuclear region of cytoplasm|extracellular vesicular exosome|,"protein complex assembly|substrate-dependent cell migration, cell extension|mitotic nuclear division|signal transduction|vesicle organization|single organismal cell-cell adhesion|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of receptor-mediated endocytosis|",vascular endothelial growth factor receptor binding|structural constituent of cytoskeleton|protein binding|beta-catenin binding|protein C-terminus binding|SH3 domain binding|protein complex binding|cadherin binding|,10,0.9,0.882,10,-0.9,0.328,-0.6,0.511,0.615,-3.5,3.4
ENSMUSG00000031818,COX4I1,cytochrome c oxidase subunit IV isoform 1,nucleus|mitochondrion|mitochondrial inner membrane|membrane|extracellular vesicular exosome|,generation of precursor metabolites and energy|response to nutrient|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|hydrogen ion transmembrane transport|hydrogen ion transmembrane transport|,cytochrome-c oxidase activity|protein binding|,10,0.6,0.213,10,0.5,0.345,0.5,0.508,0.616,-7.4,3
ENSMUSG00000041025,IFFO2,intermediate filament family orphan 2,intermediate filament|,None,structural molecule activity|,0,0,0,1,-1.9,0.551,-1.9,0.507,0.616,-3,1.7
ENSMUSG00000045440,INSM2,insulinoma-associated 2,nucleus|cytoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|metal ion binding|,0,0,0,1,-1.9,0.551,-1.9,0.507,0.616,-3,1.7
ENSMUSG00000038957,EDC3,enhancer of mRNA decapping 3,cytoplasmic mRNA processing body|cytosol|membrane|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|gene expression|RNA metabolic process|mRNA metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|",RNA binding|protein binding|identical protein binding|,0,0,0,1,-1.9,0.551,-1.9,0.507,0.616,-3,1.7
ENSMUSG00000094439,GM21969,N/A,None,None,None,0,0,0,1,-1.9,0.551,-1.9,0.507,0.616,-3,1.7
ENSMUSG00000036120,RFXANK,regulatory factor X-associated ankyrin-containing protein,nucleus|cytoplasm|intercellular bridge|,"transcription, DNA-templated|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|histone deacetylase binding|,0,0,0,1,-1.9,0.549,-1.9,0.505,0.617,-3,1.7
ENSMUSG00000023224,SERPING1,"serpin peptidase inhibitor, clade G (C1 inhibitor), member 1",extracellular region|extracellular region|extracellular space|extracellular space|platelet alpha granule lumen|extracellular vesicular exosome|blood microparticle|,"negative regulation of complement activation, lectin pathway|platelet degranulation|complement activation, classical pathway|blood coagulation|blood coagulation, intrinsic pathway|blood circulation|negative regulation of endopeptidase activity|platelet activation|fibrinolysis|innate immune response|",serine-type endopeptidase inhibitor activity|protein binding|,10,-0.7,0.595,10,-0.2,0.0606,-0.5,0.505,0.617,-7.6,2.5
ENSMUSG00000041845,RHOD,ras homolog family member D,cytosol|plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|Rho protein signal transduction|regulation of small GTPase mediated signal transduction|,GTPase activity|GTP binding|,10,6.5,3.13,10,0,0,-0.6,0.504,0.617,-3.4,13.4
ENSMUSG00000032494,TDGF1,teratocarcinoma-derived growth factor 1,extracellular space|nucleus|Golgi apparatus|cell surface|apical plasma membrane|extrinsic component of plasma membrane|anchored component of membrane|membrane raft|perinuclear region of cytoplasm|,"activation of MAPK activity|vasculogenesis|in utero embryonic development|morphogenesis of a branching structure|positive regulation of cell-matrix adhesion|cell migration involved in sprouting angiogenesis|gastrulation|heart development|positive regulation of cell proliferation|positive regulation of cell proliferation|anterior/posterior axis specification, embryo|embryo development|regulation of signal transduction|positive regulation of endothelial cell migration|peptidyl-serine phosphorylation|cell differentiation|positive regulation of cell migration|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|mammary gland development|cellular response to hepatocyte growth factor stimulus|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of peptidyl-tyrosine phosphorylation|cardiac muscle cell differentiation|canonical Wnt signaling pathway|cellular response to interferon-gamma|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|",receptor binding|protein binding|growth factor activity|,10,5.3,1.73,10,0.2,0.0658,0.4,0.504,0.617,-5.1,12
ENSMUSG00000028583,PDPN,podoplanin,ruffle|plasma membrane|integral component of plasma membrane|external side of plasma membrane|apical plasma membrane|lamellipodium|filopodium|lamellipodium membrane|filopodium membrane|microvillus membrane|ruffle membrane|,cell morphogenesis|lymphangiogenesis|prostaglandin metabolic process|cellular component movement|inflammatory response|signal transduction|nervous system development|cell proliferation|regulation of cell shape|embryo development|positive regulation of platelet activation|single organismal cell-cell adhesion|lung development|positive regulation of cell migration|tube morphogenesis|lung alveolus development|positive regulation of cellular component movement|response to hyperoxia|regulation of G1/S transition of mitotic cell cycle|,None,10,1.5,0.944,10,-0.8,0.203,0.8,0.503,0.617,-6.8,5.1
ENSMUSG00000026005,RPE,ribulose-5-phosphate-3-epimerase,cytosol|,carbohydrate metabolic process|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt|small molecule metabolic process|,ribulose-phosphate 3-epimerase activity|ribulose-phosphate 3-epimerase activity|identical protein binding|protein homodimerization activity|metal ion binding|,9,-1.5,1.04,9,0.5,0.133,0.7,0.502,0.618,-7.9,5.1
ENSMUSG00000028820,SFPQ,splicing factor proline/glutamine-rich,None,None,None,10,-2.1,0.811,10,2.3,0.846,0.6,0.502,0.618,-5.7,5
ENSMUSG00000032281,ACSBG1,acyl-CoA synthetase bubblegum family member 1,cytoplasm|endoplasmic reticulum|cytoplasmic membrane-bounded vesicle|,very long-chain fatty acid metabolic process|ovarian follicle atresia|long-chain fatty acid metabolic process|myelination|response to glucocorticoid|,long-chain fatty acid-CoA ligase activity|ATP binding|very long-chain fatty acid-CoA ligase activity|,10,1.1,0.949,10,0.1,0.00285,0.6,0.501,0.618,-3.3,6.2
ENSMUSG00000000078,KLF6,Kruppel-like factor 6,nucleus|cytoplasm|,"transcription, DNA-templated|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of transcription, DNA-templated|",DNA binding|metal ion binding|,10,0.7,0.481,10,-1.7,0.465,0.7,0.501,0.618,-5.6,4.5
ENSMUSG00000020407,UPP1,uridine phosphorylase 1,cytosol|,nucleobase-containing compound metabolic process|pyrimidine nucleobase metabolic process|nucleotide catabolic process|cellular response to glucose starvation|pyrimidine nucleoside salvage|UMP salvage|small molecule metabolic process|uridine metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|,uridine phosphorylase activity|,10,-0.7,0.275,10,-1.3,0.405,-0.9,0.5,0.619,-5.4,3.1
ENSMUSG00000092232,GM20521,N/A,None,None,None,5,0.9,0.965,5,-0.3,0.0413,0.7,0.498,0.619,-3,3.2
ENSMUSG00000027951,ADAR,"adenosine deaminase, RNA-specific",nucleus|nucleus|nucleoplasm|nucleolus|cytoplasm|cytoplasm|membrane|supraspliceosomal complex|,adenosine to inosine editing|adenosine to inosine editing|adenosine to inosine editing|mRNA processing|protein import into nucleus|protein export from nucleus|response to virus|gene expression|base conversion or substitution editing|mRNA modification|cytokine-mediated signaling pathway|gene silencing by RNA|response to interferon-alpha|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of viral genome replication|positive regulation of viral genome replication|innate immune response|defense response to virus|type I interferon signaling pathway|,DNA binding|double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|protein binding|poly(A) RNA binding|metal ion binding|,10,1.5,0.414,10,-5.3,1.35,-0.6,0.492,0.622,-10.4,3.3
ENSMUSG00000030322,MBD4,methyl-CpG binding domain protein 4,chromatin|nucleus|nucleoplasm|cytoplasm|,"DNA catabolic process, endonucleolytic|DNA repair|base-excision repair|base-excision repair, AP site formation|mitotic G2 DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage|response to radiation|depyrimidination|",satellite DNA binding|endodeoxyribonuclease activity|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|,10,-0.2,0.0129,10,-1.1,0.84,-0.7,0.492,0.622,-4.9,3.3
ENSMUSG00000056209,NPM3,nucleophosmin/nucleoplasmin 3,nucleolus|,rRNA processing|rRNA transcription|,protein binding|poly(A) RNA binding|,1,-1.2,0.535,0,0,0,-1.2,0.492,0.622,-3,1.7
ENSMUSG00000049658,BDP1,"B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB",nucleus|nucleoplasm|cytoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase III promoter|gene expression|",DNA binding|chromatin binding|,1,1.2,0.535,0,0,0,1.2,0.492,0.622,-1.7,3
ENSMUSG00000017386,TRAF4,TNF receptor-associated factor 4,nucleus|cytoplasm|cytoskeleton|plasma membrane|tight junction|perinuclear region of cytoplasm|,apoptotic process|signal transduction|activation of NF-kappaB-inducing kinase activity|respiratory gaseous exchange|protein ubiquitination|respiratory tube development|regulation of apoptotic process|positive regulation of protein kinase activity|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|,DNA binding|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|zinc ion binding|protein kinase binding|ubiquitin protein ligase binding|thioesterase binding|WW domain binding|,10,-0.6,0.412,10,-0.4,0.175,-0.5,0.491,0.622,-8.7,2
ENSMUSG00000033294,NOC4L,nucleolar complex associated 4 homolog (S. cerevisiae),nucleus|nucleolus|nucleolus|integral component of membrane|nuclear membrane|,rRNA processing|,protein binding|poly(A) RNA binding|,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000034659,TMEM109,transmembrane protein 109,nuclear outer membrane|integral component of membrane|sarcoplasmic reticulum membrane|extracellular vesicular exosome|,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of cell death|cellular response to gamma radiation|,molecular_function|,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000059455,PLAC8L1,PLAC8-like 1,None,None,None,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000010607,PIGYL,"phosphatidylinositol glycan anchor biosynthesis, class Y-like",cellular_component|endoplasmic reticulum|membrane|integral component of membrane|,GPI anchor biosynthetic process|biological_process|,molecular_function|,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000039956,MRAP,melanocortin 2 receptor accessory protein,endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|,positive regulation of cAMP biosynthetic process|protein localization to cell surface|brown fat cell differentiation|,corticotropin hormone receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding|type 1 melanocortin receptor binding|,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000038838,VARS2,"valyl-tRNA synthetase 2, mitochondrial",mitochondrion|,tRNA aminoacylation for protein translation|valyl-tRNA aminoacylation|regulation of translational fidelity|gene expression|,aminoacyl-tRNA editing activity|valine-tRNA ligase activity|ATP binding|,0,0,0,1,1.3,0.533,1.3,0.49,0.622,-1.7,3
ENSMUSG00000002326,GMPR2,guanosine monophosphate reductase 2,cytosol|GMP reductase complex|,purine nucleobase metabolic process|purine-containing compound salvage|small molecule metabolic process|GMP metabolic process|nucleobase-containing small molecule metabolic process|oxidation-reduction process|,GMP reductase activity|metal ion binding|,10,-0.1,0.017,10,5,1.14,3.6,0.489,0.622,-2.1,10
ENSMUSG00000096458,MOAP1,modulator of apoptosis 1,cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|,protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|,protein binding|ubiquitin protein ligase binding|,10,-1.1,1.39,10,0,0,-0.8,0.488,0.623,-5.6,7.4
ENSMUSG00000038342,MLXIP,MLX interacting protein,nucleus|mitochondrial outer membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|",DNA binding|protein dimerization activity|,0,0,0,1,-1.9,0.529,-1.9,0.486,0.624,-3,1.7
ENSMUSG00000035310,LIN54,lin-54 DREAM MuvB core complex component,nucleoplasm|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of cell cycle|",DNA binding|protein binding|,0,0,0,1,-1.9,0.529,-1.9,0.486,0.624,-3,1.7
ENSMUSG00000036598,CCDC113,coiled-coil domain containing 113,nucleus|cytoplasm|protein complex|,None,None,0,0,0,1,-1.9,0.529,-1.9,0.486,0.624,-3,1.7
ENSMUSG00000020063,SIRT1,sirtuin 1,nuclear chromatin|nucleus|nuclear envelope|nuclear inner membrane|nucleoplasm|chromatin silencing complex|nuclear euchromatin|nuclear heterochromatin|nucleolus|cytoplasm|mitochondrion|PML body|rDNA heterochromatin|ESC/E(Z) complex|,"single strand break repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|pyrimidine dimer repair by nucleotide-excision repair|DNA synthesis involved in DNA repair|angiogenesis|ovulation from ovarian follicle|cellular glucose homeostasis|positive regulation of protein phosphorylation|positive regulation of adaptive immune response|DNA replication|DNA repair|chromatin organization|chromatin silencing|establishment of chromatin silencing|maintenance of chromatin silencing|methylation-dependent chromatin silencing|transcription, DNA-templated|rRNA processing|protein deacetylation|protein deacetylation|triglyceride mobilization|cellular response to DNA damage stimulus|response to oxidative stress|spermatogenesis|regulation of mitotic cell cycle|muscle organ development|cell aging|positive regulation of cell proliferation|cellular response to starvation|positive regulation of cholesterol efflux|regulation of glucose metabolic process|viral process|positive regulation of macroautophagy|protein ubiquitination|histone deacetylation|peptidyl-lysine acetylation|negative regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of prostaglandin biosynthetic process|protein destabilization|positive regulation of chromatin silencing|negative regulation of TOR signaling|regulation of endodeoxyribonuclease activity|negative regulation of NF-kappaB transcription factor activity|response to insulin|regulation of protein import into nucleus, translocation|regulation of smooth muscle cell apoptotic process|peptidyl-lysine deacetylation|cellular triglyceride homeostasis|regulation of peroxisome proliferator activated receptor signaling pathway|regulation of cell proliferation|negative regulation of phosphorylation|response to hydrogen peroxide|cholesterol homeostasis|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of MHC class II biosynthetic process|negative regulation of fat cell differentiation|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of insulin receptor signaling pathway|white fat cell differentiation|negative regulation of helicase activity|positive regulation of histone H3-K9 methylation|negative regulation of protein kinase B signaling|fatty acid homeostasis|negative regulation of androgen receptor signaling pathway|cellular response to hydrogen peroxide|regulation of bile acid biosynthetic process|histone H3 deacetylation|histone H3 deacetylation|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to ionizing radiation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of macrophage apoptotic process|negative regulation of cAMP-dependent protein kinase activity|positive regulation of cAMP-dependent protein kinase activity|negative regulation of cellular response to testosterone stimulus|negative regulation of peptidyl-lysine acetylation|negative regulation of cellular senescence|positive regulation of cellular senescence|",p53 binding|transcription corepressor activity|transcription corepressor activity|histone deacetylase activity|protein binding|protein C-terminus binding|transcription factor binding|NAD-dependent histone deacetylase activity|deacetylase activity|enzyme binding|protein deacetylase activity|NAD-dependent protein deacetylase activity|NAD-dependent protein deacetylase activity|histone binding|identical protein binding|HLH domain binding|bHLH transcription factor binding|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|mitogen-activated protein kinase binding|NAD+ binding|keratin filament binding|,10,0.8,0.882,10,-0.1,0.0215,0.5,0.486,0.624,-2.7,3.5
ENSMUSG00000055150,ZFP78,zinc finger protein 78,nucleus|,biological_process|,molecular_function|metal ion binding|,0,0,0,1,-1.9,0.529,-1.9,0.486,0.624,-3,1.7
ENSMUSG00000026504,SDCCAG8,serologically defined colon cancer antigen 8,centrosome|centriole|cytosol|cell-cell junction|,G2/M transition of mitotic cell cycle|mitotic cell cycle|establishment of cell polarity|tube formation|,protein binding|,8,1.5,1.58,10,-0.6,0.138,0.6,0.485,0.624,-3.3,3.9
ENSMUSG00000023249,PARP3,"poly (ADP-ribose) polymerase family, member 3",nucleus|centriole|site of double-strand break|,telomere maintenance|DNA repair|double-strand break repair|double-strand break repair|protein ADP-ribosylation|positive regulation of DNA ligation|regulation of mitotic spindle organization|protein localization to site of double-strand break|,catalytic activity|NAD+ ADP-ribosyltransferase activity|,10,0.2,0.0416,10,-0.8,0.655,-0.8,0.483,0.625,-5.8,3.5
ENSMUSG00000029229,CHIC2,cysteine-rich hydrophobic domain 2,cellular_component|Golgi-associated vesicle|plasma membrane|,biological_process|,molecular_function|protein binding|,10,1.2,0.762,9,-1.1,0.534,-1.2,0.482,0.625,-6.5,5.2
ENSMUSG00000044340,PHLPP1,PH domain and leucine rich repeat protein phosphatase 1,nucleus|cytosol|membrane|,apoptotic process|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|entrainment of circadian clock|dephosphorylation|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|,phosphoprotein phosphatase activity|protein binding|metal ion binding|,10,4.9,1.37,10,0,0,3.9,0.482,0.625,-1.6,9.9
ENSMUSG00000015149,SIRT2,sirtuin 2,nucleus|chromatin silencing complex|chromosome|nuclear heterochromatin|cytoplasm|centrosome|centriole|spindle|cytosol|microtubule|plasma membrane|growth cone|midbody|paranodal junction|paranode region of axon|perikaryon|myelin sheath|lateral loop|Schmidt-Lanterman incisure|juxtaparanode region of axon|perinuclear region of cytoplasm|mitotic spindle|meiotic spindle|glial cell projection|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin silencing|chromatin silencing at telomere|transcription, DNA-templated|protein ADP-ribosylation|protein deacetylation|protein deacetylation|autophagy|mitotic nuclear division|regulation of exit from mitosis|meiotic nuclear division|cell death|negative regulation of cell proliferation|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|phosphatidylinositol 3-kinase signaling|gene silencing|histone deacetylation|histone deacetylation|substantia nigra development|myelination in peripheral nervous system|regulation of myelination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to oxidative stress|peptidyl-lysine deacetylation|cellular response to hepatocyte growth factor stimulus|negative regulation of protein catabolic process|regulation of phosphorylation|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA binding|protein kinase B signaling|cellular lipid catabolic process|innate immune response|negative regulation of fat cell differentiation|positive regulation of meiosis|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|hepatocyte growth factor receptor signaling pathway|regulation of cell cycle|response to redox state|positive regulation of cell division|positive regulation of attachment of spindle microtubules to kinetochore|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to caloric restriction|negative regulation of oligodendrocyte progenitor proliferation|histone H3 deacetylation|histone H4 deacetylation|cellular response to molecule of bacterial origin|cellular response to hypoxia|cellular response to epinephrine stimulus|tubulin deacetylation|tubulin deacetylation|tubulin deacetylation|positive regulation of execution phase of apoptosis|positive regulation of oocyte maturation|negative regulation of defense response to bacterium|negative regulation of reactive oxygen species metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia|",chromatin binding|histone deacetylase activity|protein binding|transcription factor binding|zinc ion binding|NAD-dependent histone deacetylase activity|protein deacetylase activity|protein deacetylase activity|NAD-dependent protein deacetylase activity|NAD-dependent protein deacetylase activity|histone acetyltransferase binding|histone deacetylase binding|tubulin deacetylase activity|ubiquitin binding|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD+ binding|,10,-3.1,2.96,10,-0.1,0.0113,-2.9,0.481,0.625,-6.8,3.1
ENSMUSG00000027570,COL9A3,"collagen, type IX, alpha 3",extracellular region|collagen type IX trimer|endoplasmic reticulum lumen|,axon guidance|male gonad development|female gonad development|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|,extracellular matrix structural constituent conferring tensile strength|,9,-0.7,0.3,9,1.2,0.892,-1.5,0.481,0.625,-5.9,5
ENSMUSG00000027259,ADAL,adenosine deaminase-like,cytosol|,purine nucleobase metabolic process|adenosine catabolic process|nucleotide metabolic process|drug metabolic process|purine-containing compound salvage|small molecule metabolic process|inosine biosynthetic process|nucleobase-containing small molecule metabolic process|,adenosine deaminase activity|adenosine deaminase activity|metal ion binding|,0,0,0,1,1.3,0.52,1.3,0.478,0.627,-1.7,3
ENSMUSG00000027635,DSN1,"DSN1, MIS12 kinetochore complex component",MIS12/MIND type complex|nucleus|cytosol|,mitotic cell cycle|chromosome segregation|mitotic nuclear division|,protein binding|,10,-5,0.121,10,1.6,1.03,1,0.475,0.628,-8,7.4
ENSMUSG00000000402,EGFL6,"EGF-like-domain, multiple 6",basement membrane|extracellular space|membrane|,cell cycle|cell adhesion|multicellular organismal development|positive regulation of cell-substrate adhesion|cell differentiation|extracellular matrix organization|,integrin binding|calcium ion binding|,10,2,1.28,10,0,0,0.9,0.474,0.628,-2.9,6.5
ENSMUSG00000031239,ITM2A,integral membrane protein 2A,integral component of membrane|,None,protein binding|,10,0.4,0.158,10,0.7,0.417,0.5,0.473,0.629,-2.2,4.2
ENSMUSG00000029730,MCM7,minichromosome maintenance complex component 7,chromatin|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|MCM complex|MCM complex|,G1/S transition of mitotic cell cycle|mitotic cell cycle|DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|cellular response to DNA damage stimulus|cell proliferation|regulation of phosphorylation|response to drug|cellular response to epidermal growth factor stimulus|,DNA binding|single-stranded DNA binding|ATP-dependent DNA helicase activity|protein binding|ATP binding|,5,-4.7,1.59,5,3.6,1.65,-0.8,0.473,0.629,-8.1,7.7
ENSMUSG00000025958,CREB1,cAMP responsive element binding protein 1,nucleus|nucleoplasm|transcription factor complex|nuclear euchromatin|,"toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription from RNA polymerase II promoter|protein phosphorylation|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|Notch signaling pathway|synaptic transmission|axon guidance|lactation|circadian rhythm|regulation of cell size|fibroblast growth factor receptor signaling pathway|response to organic substance|negative regulation of transcription by competitive promoter binding|viral process|pituitary gland development|secretory granule organization|response to glucagon|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of multicellular organism growth|response to drug|innate immune response|positive regulation of fat cell differentiation|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hormone secretion|positive regulation of lipid biosynthetic process|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|protein stabilization|stress-activated MAPK cascade|lung saccule development|Type I pneumocyte differentiation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription cofactor activity|protein binding|enzyme binding|cAMP response element binding|,10,-1.3,0.729,10,-0.5,0.22,-1,0.472,0.629,-8.4,2.8
ENSMUSG00000016758,BIK,BCL2-interacting killer (apoptosis-inducing),endomembrane system|integral component of membrane|mitochondrial membrane|,apoptotic process|spermatogenesis|male gonad development|apoptotic mitochondrial changes|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|,protein binding|protein heterodimerization activity|BH domain binding|,10,-1.8,0.583,10,2,1.08,0.7,0.472,0.629,-6.4,6.4
ENSMUSG00000021156,ZMYND11,"zinc finger, MYND-type containing 11",nucleus|chromosome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|cell cycle|cell proliferation|viral process|chromatin modification|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of JNK cascade|negative regulation of extrinsic apoptotic signaling pathway|",DNA binding|transcription corepressor activity|protein binding|zinc ion binding|methylated histone binding|,9,-0.6,0.297,9,-0.7,0.221,-0.6,0.472,0.629,-5,7
ENSMUSG00000001655,HOXC13,homeobox C13,nucleus|,"hair follicle development|transcription, DNA-templated|anatomical structure morphogenesis|anterior/posterior pattern specification|nail development|tongue morphogenesis|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|protein binding|sequence-specific DNA binding|,10,-1.9,1,10,2.1,1.29,-1.7,0.471,0.629,-4.1,4.5
ENSMUSG00000020432,TCN2,transcobalamin II,extracellular region|extracellular space|endosome|lysosomal lumen|extracellular vesicular exosome|,vitamin metabolic process|water-soluble vitamin metabolic process|cobalt ion transport|cobalamin metabolic process|cobalamin metabolic process|cobalamin transport|small molecule metabolic process|,cobalamin binding|cobalamin binding|metal ion binding|,10,0.9,1.06,10,-0.4,0.166,0.7,0.47,0.63,-3.4,4.2
ENSMUSG00000057021,VMN2R-PS159,"vomeronasal 2, receptor, pseudogene 159",None,None,None,10,-5.9,0.929,10,-0.1,0.0264,-0.4,0.469,0.63,-11.5,3.7
ENSMUSG00000031616,EDNRA,endothelin receptor type A,plasma membrane|integral component of plasma membrane|T-tubule|nuclear membrane|,patterning of blood vessels|response to hypoxia|in utero embryonic development|histamine secretion|positive regulation of protein phosphorylation|glomerular filtration|smooth muscle contraction|signal transduction|G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G-protein coupled receptor signaling pathway|Rho protein signal transduction|heart development|aging|respiratory gaseous exchange|metabolic process|regulation of blood pressure|cell proliferation|positive regulation of cell proliferation|neural crest cell development|artery smooth muscle contraction|glucose transport|sensory perception of pain|negative regulation of cAMP biosynthetic process|response to lipopolysaccharide|vasoconstriction|positive regulation of odontogenesis|negative regulation of apoptotic process|penile erection|response to morphine|fibroblast proliferation|enteric nervous system development|smooth muscle cell proliferation|regulation of epithelial cell proliferation|positive regulation of inflammatory response|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|maternal process involved in parturition|head development|positive regulation of ERK1 and ERK2 cascade|cellular response to mechanical stimulus|endothelin receptor signaling pathway|positive regulation of neutrophil chemotaxis|positive regulation of kidney development|,phosphatidylinositol phospholipase C activity|endothelin receptor activity|protein binding|,10,0.6,0.105,10,0.5,0.415,0.6,0.469,0.63,-3.8,4.5
ENSMUSG00000048138,DMRT2,doublesex and mab-3 related transcription factor 2,cellular_component|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|sex determination|biological_process|male gonad development|regulation of somitogenesis|embryonic skeletal system development|positive regulation of myotome development|",molecular_function|sequence-specific DNA binding transcription factor activity|protein homodimerization activity|sequence-specific DNA binding|metal ion binding|,0,0,0,1,-1.9,0.51,-1.9,0.468,0.63,-3,1.7
ENSMUSG00000037487,UBR5,ubiquitin protein ligase E3 component n-recognin 5,nucleus|cytoplasm|cytoplasm|membrane|,"protein polyubiquitination|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cellular response to DNA damage stimulus|cell proliferation|positive regulation of protein import into nucleus, translocation|positive regulation of catenin import into nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|progesterone receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair|",RNA binding|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|ubiquitin-ubiquitin ligase activity|ubiquitin binding|,9,1.3,1.83,10,-0.2,0.0492,0.8,0.468,0.63,-4.6,5.5
ENSMUSG00000045008,9030612E09RIK,RIKEN cDNA 9030612E09 gene,cellular_component|,biological_process|,molecular_function|,1,-1.2,0.509,0,0,0,-1.2,0.467,0.631,-3,1.7
ENSMUSG00000050910,CDR2L,cerebellar degeneration-related protein 2-like,None,None,None,0,0,0,1,-1.8,0.507,-1.8,0.466,0.631,-3,1.7
ENSMUSG00000020307,CDC34,cell division cycle 34,nucleus|nucleus|cytoplasm|,G1/S transition of mitotic cell cycle|protein polyubiquitination|DNA replication initiation|cellular protein modification process|protein ubiquitination|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|negative regulation of cAMP-mediated signaling|response to growth factor|protein K48-linked ubiquitination|positive regulation of inclusion body assembly|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|,10,-2.8,3.15,10,0.8,0.632,0.4,0.466,0.631,-6,3.2
ENSMUSG00000002396,OCEL1,occludin/ELL domain containing 1,None,None,None,0,0,0,1,-1.8,0.507,-1.8,0.466,0.631,-3,1.7
ENSMUSG00000043542,ZC2HC1A,"zinc finger, C2HC-type containing 1A",None,None,metal ion binding|,0,0,0,1,-1.8,0.507,-1.8,0.466,0.631,-3,1.7
ENSMUSG00000078284,CDC73,cell division cycle 73,nucleus|Cdc73/Paf1 complex|,"negative regulation of transcription from RNA polymerase II promoter|endodermal cell fate commitment|transcription, DNA-templated|mRNA polyadenylation|cell cycle|negative regulation of cell proliferation|histone monoubiquitination|Wnt signaling pathway|stem cell maintenance|positive regulation of Wnt signaling pathway|positive regulation of mRNA 3'-end processing|protein destabilization|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation|cellular response to lipopolysaccharide|negative regulation of G1/S transition of mitotic cell cycle|",RNA polymerase II core binding|protein binding|,3,-3,1.54,3,0,0,-0.8,0.464,0.632,-6.6,1.6
ENSMUSG00000031285,DCX,doublecortin,cytosol|cytoskeleton|microtubule|microtubule associated complex|neuron projection|,neuron migration|nervous system development|axon guidance|central nervous system development|brain development|central nervous system projection neuron axonogenesis|intracellular signal transduction|axon extension|dendrite morphogenesis|,protein binding|microtubule binding|protein kinase binding|,10,-1.5,0.938,10,-0.5,0.103,-0.9,0.463,0.632,-5.4,1.5
ENSMUSG00000025658,CNKSR2,connector enhancer of kinase suppressor of Ras 2,Golgi apparatus|plasma membrane|neuron projection|neuronal cell body|postsynaptic membrane|extracellular vesicular exosome|,regulation of signal transduction|,identical protein binding|,9,0,0,10,-1,0.869,-0.8,0.463,0.632,-4.5,2.5
ENSMUSG00000050295,FOXC1,forkhead box C1,nucleus|nucleus|nuclear heterochromatin|cytoplasm|,"skeletal system development|ossification|ovarian follicle development|eye development|ureteric bud development|in utero embryonic development|somitogenesis|kidney development|lymph vessel development|blood vessel remodeling|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|Notch signaling pathway|brain development|heart development|germ cell migration|neural crest cell development|collagen fibril organization|glycosaminoglycan metabolic process|lacrimal gland development|embryonic heart tube development|odontogenesis of dentin-containing tooth|camera-type eye development|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of organ growth|vascular endothelial growth factor receptor signaling pathway|paraxial mesoderm formation|artery morphogenesis|regulation of blood vessel size|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|negative regulation of apoptotic process involved in outflow tract morphogenesis|","RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|DNA binding, bending|sequence-specific DNA binding|transcription regulatory region DNA binding|",10,-1,0.675,10,-0.2,0.0325,-0.7,0.462,0.633,-7,2.8
ENSMUSG00000001016,ILF2,interleukin enhancer binding factor 2,nucleus|nucleolus|cytoplasm|membrane|ribonucleoprotein complex|,"transcription, DNA-templated|immune response|positive regulation of transcription, DNA-templated|",DNA binding|double-stranded RNA binding|protein binding|ATP binding|transferase activity|poly(A) RNA binding|,1,-1.2,0.503,0,0,0,-1.2,0.462,0.633,-3,1.7
ENSMUSG00000038914,DIDO1,death inducer-obliterator 1,nucleus|cytoplasm|spindle|,"transcription, DNA-templated|apoptotic signaling pathway|",zinc ion binding|poly(A) RNA binding|,10,1.1,0.402,10,-1.1,0.993,-1.2,0.461,0.633,-5.1,3.9
ENSMUSG00000028224,NBN,nibrin,"nuclear chromosome, telomeric region|nucleus|nucleoplasm|replication fork|nucleolus|PML body|Mre11 complex|site of double-strand break|nuclear inclusion body|","DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|blastocyst growth|DNA repair|double-strand break repair|double-strand break repair|cell cycle arrest|mitotic cell cycle checkpoint|mitotic G2 DNA damage checkpoint|meiotic nuclear division|cell proliferation|regulation of DNA-dependent DNA replication initiation|DNA damage response, signal transduction by p53 class mediator|positive regulation of protein autophosphorylation|DNA duplex unwinding|positive regulation of kinase activity|isotype switching|neuromuscular process controlling balance|intrinsic apoptotic signaling pathway|",damaged DNA binding|ATP-dependent DNA helicase activity|protein binding|transcription factor binding|protein N-terminus binding|,10,0.3,0.0659,10,0.6,0.481,0.5,0.459,0.633,-3.7,4.8
ENSMUSG00000022037,CLU,clusterin,extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|extracellular matrix|platelet alpha granule lumen|mitochondrial membrane|spherical high-density lipoprotein particle|chromaffin granule|perinuclear region of cytoplasm|extracellular vesicular exosome|blood microparticle|neurofibrillary tangle|apical dendrite|,"cell morphogenesis|microglial cell activation|release of cytochrome c from mitochondria|platelet degranulation|lipid metabolic process|complement activation|complement activation, classical pathway|blood coagulation|response to virus|protein import|platelet activation|central nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein homooligomerization|positive regulation of tumor necrosis factor production|positive regulation of apoptotic process|reverse cholesterol transport|innate immune response|positive regulation of nitric oxide biosynthetic process|protein stabilization|positive regulation of NF-kappaB transcription factor activity|chaperone-mediated protein complex assembly|response to misfolded protein|chaperone-mediated protein folding|microglial cell proliferation|intrinsic apoptotic signaling pathway|regulation of beta-amyloid clearance|regulation of neuron death|regulation of neuron death|positive regulation of neuron death|positive regulation of neuron death|positive regulation of beta-amyloid formation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of beta-amyloid formation|regulation of neuronal signal transduction|positive regulation of tau-protein kinase activity|positive regulation of neurofibrillary tangle assembly|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of intrinsic apoptotic signaling pathway|",protein binding|ubiquitin protein ligase binding|misfolded protein binding|misfolded protein binding|,10,-1.6,0.745,10,-0.3,0.121,-0.8,0.459,0.633,-4.1,2.1
ENSMUSG00000024795,KIF20B,kinesin family member 20B,nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|spindle|microtubule|,mitotic M phase|ATP catabolic process|microtubule-based movement|cell cycle arrest|mitotic nuclear division|regulation of mitosis|,microtubule motor activity|ATP binding|microtubule binding|ATPase activity|WW domain binding|,9,-4.1,0.255,10,-1.1,1,-1.1,0.458,0.634,-8.2,4.1
ENSMUSG00000070002,ELL,elongation factor RNA polymerase II,nucleoplasm|transcription elongation factor complex|Cajal body|nuclear speck|,"in utero embryonic development|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|negative regulation of phosphatase activity|viral process|positive regulation of DNA-templated transcription, elongation|positive regulation of viral transcription|",protein binding|phosphatase binding|,10,-1.6,1.37,10,0,0,-0.4,0.455,0.635,-10,6.7
ENSMUSG00000022141,NIPBL,Nipped-B homolog (Drosophila),nucleus|nucleoplasm|SMC loading complex|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|metanephros development|heart morphogenesis|outflow tract morphogenesis|cellular response to DNA damage stimulus|mitotic sister chromatid cohesion|brain development|sensory perception of sound|stem cell maintenance|positive regulation of histone deacetylation|maintenance of mitotic sister chromatid cohesion|cellular protein localization|embryonic forelimb morphogenesis|forelimb morphogenesis|external genitalia morphogenesis|positive regulation of multicellular organism growth|ear morphogenesis|regulation of hair cycle|fat cell differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated|regulation of embryonic development|embryonic digestive tract morphogenesis|developmental growth|eye morphogenesis|regulation of developmental growth|embryonic viscerocranium morphogenesis|cognition|face morphogenesis|gall bladder development|uterus morphogenesis|cellular response to X-ray|",chromatin binding|protein binding|protein C-terminus binding|mediator complex binding|histone deacetylase binding|protein N-terminus binding|chromo shadow domain binding|,9,1.9,0.131,10,-1,0.813,-0.7,0.455,0.635,-6.6,8
ENSMUSG00000000182,FGF23,fibroblast growth factor 23,extracellular region|extracellular space|extracellular space|,"phosphate-containing compound metabolic process|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|regulation of phosphate transport|positive regulation of vitamin D 24-hydroxylase activity|cell differentiation|negative regulation of bone mineralization|cellular phosphate ion homeostasis|Fc-epsilon receptor signaling pathway|vitamin D catabolic process|innate immune response|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|negative regulation of hormone secretion|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|phosphate ion homeostasis|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|",type 1 fibroblast growth factor receptor binding|growth factor activity|,10,0.8,0.467,10,0.4,0.165,0.6,0.452,0.636,-1.7,3.1
ENSMUSG00000026321,TNFRSF11A,"tumor necrosis factor receptor superfamily, member 11a, NFKB activator",external side of plasma membrane|integral component of membrane|,ossification|adaptive immune response|monocyte chemotaxis|signal transduction|cell-cell signaling|positive regulation of cell proliferation|response to radiation|osteoclast differentiation|response to lipopolysaccharide|tumor necrosis factor-mediated signaling pathway|response to cytokine|response to tumor necrosis factor|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JUN kinase activity|lymph node development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|circadian temperature homeostasis|mammary gland alveolus development|response to interleukin-1|positive regulation of fever generation by positive regulation of prostaglandin secretion|TNFSF11-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|,receptor activity|transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|protein binding|cytokine binding|metal ion binding|,10,0.6,0.451,10,0.5,0.0508,0.6,0.452,0.636,-6.8,3
ENSMUSG00000032875,ARHGEF17,Rho guanine nucleotide exchange factor (GEF) 17,cytosol|,small GTPase mediated signal transduction|actin cytoskeleton organization|positive regulation of Rho GTPase activity|positive regulation of apoptotic process|positive regulation of GTPase activity|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000063713,KLK1B24,kallikrein 1-related peptidase b24,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,4,1.08,10,0.6,0.123,3.1,0.45,0.637,-3,8.9
ENSMUSG00000035606,KY,kyphoscoliosis peptidase,cytoskeleton|Z disc|,proteolysis|muscle organ development|neuromuscular junction development|,peptidase activity|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000029348,ASPHD2,aspartate beta-hydroxylase domain containing 2,membrane|integral component of membrane|,peptidyl-amino acid modification|oxidation-reduction process|,metal ion binding|dioxygenase activity|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000025555,FARP1,"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)",cytoplasm|cytosol|cytoskeleton|cell junction|filopodium|dendrite|extrinsic component of cytoplasmic side of plasma membrane|dendritic spine|synapse|,synapse assembly|negative regulation of phosphatase activity|positive regulation of Rho GTPase activity|positive regulation of Rac GTPase activity|positive regulation of Rac GTPase activity|dendrite morphogenesis|,Rho guanyl-nucleotide exchange factor activity|cytoskeletal protein binding|Rac guanyl-nucleotide exchange factor activity|Rac GTPase binding|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000042298,TTC19,tetratricopeptide repeat domain 19,mitochondrion|mitochondrial inner membrane|centrosome|midbody|,cytokinesis|mitochondrial respiratory chain complex III assembly|,protein binding|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000034209,RASL10A,"RAS-like, family 10, member A",nucleolus|plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|,GTPase activity|GTP binding|,0,0,0,1,1.3,0.49,1.3,0.45,0.637,-1.7,3
ENSMUSG00000050229,PIGM,"phosphatidylinositol glycan anchor biosynthesis, class M",endoplasmic reticulum membrane|integral component of membrane|,C-terminal protein lipidation|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|mannosylation|,mannosyltransferase activity|,10,3.7,0.912,10,0.9,0.244,0.8,0.446,0.638,-3.4,7.6
ENSMUSG00000072845,TMPRSS11A,"transmembrane protease, serine 11A",extracellular region|integral component of plasma membrane|,proteolysis|cell cycle|,serine-type endopeptidase activity|,10,-0.5,0.25,10,-1,0.298,-0.7,0.446,0.638,-5.1,2.1
ENSMUSG00000027331,KNSTRN,kinetochore-localized astrin/SPAG5 binding protein,kinetochore|condensed chromosome kinetochore|spindle pole|nucleus|cytoplasm|microtubule cytoskeleton|microtubule plus-end|mitotic spindle|,mitotic sister chromatid segregation|spindle organization|chromosome segregation|regulation of attachment of spindle microtubules to kinetochore|,protein binding|,10,-1.9,0.142,10,-0.6,0.813,-0.5,0.446,0.638,-8.4,1.2
ENSMUSG00000028784,SPOCD1,SPOC domain containing 1,None,"transcription, DNA-templated|negative regulation of phosphatase activity|",None,0,0,0,1,-1.8,0.486,-1.8,0.446,0.638,-3,1.7
ENSMUSG00000024542,CEP192,centrosomal protein 192kDa,cytoplasm|centrosome|centriole|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|negative regulation of phosphatase activity|spindle assembly|centrosome duplication|,protein binding|phosphatase binding|,10,-2.3,1.61,10,0,0,-1.9,0.446,0.638,-9.5,4
ENSMUSG00000046982,TSHZ1,teashirt zinc finger homeobox 1,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|anterior/posterior pattern specification|middle ear morphogenesis|soft palate development|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|metal ion binding|,1,-1.7,0.676,1,-0.4,0.0381,-1.5,0.441,0.64,-4,1.6
ENSMUSG00000026890,LHX6,LIM homeobox 6,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|cerebral cortex GABAergic interneuron migration|forebrain neuron fate commitment|cell maturation|",sequence-specific DNA binding transcription factor activity|zinc ion binding|sequence-specific DNA binding|,0,0,0,1,-1.8,0.479,-1.8,0.44,0.64,-3,1.7
ENSMUSG00000032475,NCK1,NCK adaptor protein 1,nucleus|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|vesicle membrane|,regulation of translation|negative regulation of protein kinase activity|actin filament organization|signal complex assembly|axon guidance|cell migration|lamellipodium assembly|positive regulation of actin filament polymerization|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|T cell activation|innate immune response|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|response to other organism|negative regulation of cell death|,protein kinase inhibitor activity|receptor binding|protein binding|cytoskeletal adaptor activity|protein domain specific binding|receptor signaling complex scaffold activity|receptor tyrosine kinase binding|,10,-2,2.04,9,0,0,-1.4,0.439,0.64,-5.5,3.5
ENSMUSG00000043263,PYHIN1,"pyrin and HIN domain family, member 1",nuclear speck|,cell cycle|,None,10,0.5,0.357,10,0.4,0.121,0.5,0.437,0.641,-2,2.8
ENSMUSG00000072575,EDDM3B,epididymal protein 3B,extracellular region|,None,molecular_function|,10,-0.9,0.565,10,-0.3,0.0683,-0.7,0.434,0.643,-2.8,1.2
ENSMUSG00000038690,ATP5J2,"ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2","nucleus|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex|integral component of membrane|proton-transporting ATP synthase complex, coupling factor F(o)|extracellular vesicular exosome|",ATP catabolic process|proton transport|respiratory electron transport chain|mitochondrial ATP synthesis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|cellular metabolic process|small molecule metabolic process|,ATPase activity|transmembrane transporter activity|,10,-3.3,2.15,8,0,0,-1,0.433,0.643,-6.1,2
ENSMUSG00000005575,UBE2M,ubiquitin-conjugating enzyme E2M,cytosol|extracellular vesicular exosome|,cellular protein modification process|cellular protein modification process|transforming growth factor beta receptor signaling pathway|protein ubiquitination|protein ubiquitination|positive regulation of neuron apoptotic process|protein neddylation|protein neddylation|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|ribosomal S6-glutamic acid ligase activity|NEDD8 ligase activity|,10,0.7,0.827,10,0,0,0.5,0.433,0.643,-7.7,3.7
ENSMUSG00000049252,LRP1B,low density lipoprotein receptor-related protein 1B,integral component of membrane|receptor complex|,receptor-mediated endocytosis|protein transport|,low-density lipoprotein receptor activity|calcium ion binding|,8,-0.5,0.274,8,1.7,1.55,0.7,0.432,0.643,-2,4.7
ENSMUSG00000024780,CDC37L1,cell division cycle 37-like 1,cytoplasm|,None,None,9,0.4,0.199,10,0.9,0.517,0.7,0.431,0.644,-1.7,6.3
ENSMUSG00000023186,VWA5A,von Willebrand factor A domain containing 5A,None,None,None,10,3.3,0.955,10,-0.8,0.669,-0.5,0.43,0.644,-3.9,6.6
ENSMUSG00000024474,IK,"IK cytokine, down-regulator of HLA II",extracellular space|nucleus|,immune response|cell-cell signaling|,protein binding|identical protein binding|,10,4.2,0.43,9,-2.9,0.894,-0.5,0.429,0.644,-7.2,8.9
ENSMUSG00000026829,GBGT1,"globoside alpha-1,3-N-acetylgalactosaminyltransferase 1",Golgi membrane|integral component of membrane|,protein glycosylation|glycolipid biosynthetic process|,metal ion binding|globoside alpha-N-acetylgalactosaminyltransferase activity|,10,1.3,0.23,10,0.9,0.307,1,0.429,0.644,-3,4.7
ENSMUSG00000033308,DPYD,dihydropyrimidine dehydrogenase,cytoplasm|cytosol|cytosol|,purine nucleobase catabolic process|pyrimidine nucleobase metabolic process|pyrimidine nucleobase catabolic process|pyrimidine nucleobase catabolic process|thymine catabolic process|uracil catabolic process|thymidine catabolic process|UMP biosynthetic process|beta-alanine biosynthetic process|small molecule metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|oxidation-reduction process|,"dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|dihydropyrimidine dehydrogenase (NADP+) activity|dihydropyrimidine dehydrogenase (NADP+) activity|dihydropyrimidine dehydrogenase (NADP+) activity|protein homodimerization activity|protein homodimerization activity|metal ion binding|flavin adenine dinucleotide binding|NADP binding|4 iron, 4 sulfur cluster binding|",9,-0.7,0.202,10,-0.6,0.269,-0.6,0.428,0.645,-3.6,1.9
ENSMUSG00000045095,MAGI1,"membrane associated guanylate kinase, WW and PDZ domain containing 1",nucleus|cytoplasm|plasma membrane|cell-cell junction|tight junction|cell junction|cell projection|,protein complex assembly|cell adhesion|cell surface receptor signaling pathway|neuron death|,protein binding|ATP binding|protein C-terminus binding|alpha-actinin binding|,10,4.2,0.657,10,-0.9,0.15,-0.8,0.427,0.645,-4.9,8.5
ENSMUSG00000007867,IFT43,intraflagellar transport 43,cytoplasm|microtubule organizing center|microtubule cytoskeleton|intraciliary transport particle A|,intraciliary retrograde transport|cilium morphogenesis|,None,10,0.8,0.789,10,0,0,0.5,0.426,0.646,-2.9,3.3
ENSMUSG00000023235,CCL25,chemokine (C-C motif) ligand 25,extracellular region|extracellular space|,chemotaxis|inflammatory response|immune response|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|leukocyte migration|cell chemotaxis|cell chemotaxis|,hormone activity|chemokine activity|CCR10 chemokine receptor binding|chemokine receptor binding|,1,-1,0.409,1,1.6,0.748,1.5,0.426,0.646,-1.8,3
ENSMUSG00000052922,BPI,bactericidal/permeability-increasing protein,cytoplasm|integral component of plasma membrane|extracellular vesicular exosome|,immune response|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|defense response to bacterium|negative regulation of macrophage activation|,lipopolysaccharide binding|,0,0,0,1,-1.8,0.464,-1.8,0.426,0.646,-3,1.7
ENSMUSG00000070504,FCRL6,Fc receptor-like 6,external side of plasma membrane|integral component of membrane|,None,protein phosphatase binding|,0,0,0,1,-1.8,0.464,-1.8,0.426,0.646,-3,1.7
ENSMUSG00000028736,PAX7,paired box 7,nucleus|,chromatin remodeling|transcription from RNA polymerase II promoter|anatomical structure morphogenesis|regulation of cell fate commitment|skeletal muscle satellite cell commitment|spinal cord association neuron differentiation|dorsal/ventral neural tube patterning|positive regulation of histone methylation|negative regulation of apoptotic process|regulation of protein binding|skeletal muscle tissue regeneration|positive regulation of transcription from RNA polymerase II promoter|neuron fate commitment|embryonic skeletal system development|cartilage development|muscle tissue morphogenesis|positive regulation of myoblast proliferation|,RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0.1,0.0135,10,-0.9,0.639,-0.8,0.425,0.646,-5,2.7
ENSMUSG00000040209,ZFP704,zinc finger protein 704,None,None,metal ion binding|,1,1.1,0.462,0,0,0,1.1,0.424,0.646,-1.7,3
ENSMUSG00000006599,GTF2H1,"general transcription factor IIH, polypeptide 1, 62kDa",core TFIIH complex|nucleus|nucleoplasm|holo TFIIH complex|,"regulation of cyclin-dependent protein serine/threonine kinase activity|nucleotide-excision repair, DNA damage removal|ATP catabolic process|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|gene expression|viral process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|",protein kinase activity|protein binding|DNA-dependent ATPase activity|RNA polymerase II carboxy-terminal domain kinase activity|,10,-0.5,0.207,10,1.4,0.598,-1,0.424,0.646,-7.3,3.8
ENSMUSG00000060733,IPMK,inositol polyphosphate multikinase,nucleus|nucleoplasm|,neural tube formation|phosphorylation|inositol phosphate biosynthetic process|inositol phosphate metabolic process|small molecule metabolic process|,"inositol-1,4,5-trisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|ATP binding|inositol-1,4,5-trisphosphate 3-kinase activity|",10,-0.6,0.47,10,-0.2,0.0451,-0.5,0.424,0.646,-4.6,2.9
ENSMUSG00000030451,HERC2,HECT and RLD domain containing E3 ubiquitin protein ligase 2,nucleus|cytoplasm|mitochondrial inner membrane|centriole|membrane|,DNA repair|intracellular protein transport|cellular response to DNA damage stimulus|spermatogenesis|protein ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of GTPase activity|,ubiquitin-protein transferase activity|guanyl-nucleotide exchange factor activity|protein binding|zinc ion binding|ligase activity|heme binding|ubiquitin protein ligase binding|SUMO binding|,10,0,0,10,1.5,0.882,-1.4,0.422,0.647,-6.1,5.6
ENSMUSG00000059923,GRB2,growth factor receptor-bound protein 2,nucleus|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|COP9 signalosome|vesicle membrane|extracellular vesicular exosome|Grb2-EGFR complex|,epidermal growth factor receptor signaling pathway|Ras protein signal transduction|cell-cell signaling|axon guidance|aging|blood coagulation|insulin receptor signaling pathway|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|positive regulation of signal transduction|positive regulation of signal transduction|viral process|platelet activation|positive regulation of actin filament polymerization|T cell costimulation|receptor internalization|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of epidermal growth factor receptor signaling pathway|signal transduction in response to DNA damage|regulation of MAPK cascade|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|anatomical structure formation involved in morphogenesis|leukocyte migration|protein heterooligomerization|branching involved in labyrinthine layer morphogenesis|cellular response to ionizing radiation|positive regulation of reactive oxygen species metabolic process|,phosphotyrosine binding|SH3/SH2 adaptor activity|epidermal growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|SH3 domain binding|protein kinase binding|protein phosphatase binding|identical protein binding|insulin receptor substrate binding|poly(A) RNA binding|ephrin receptor binding|,10,0.3,0.0896,10,-0.9,1.14,-0.7,0.418,0.649,-8.5,3.6
ENSMUSG00000054196,CTHRC1,collagen triple helix repeat containing 1,proteinaceous extracellular matrix|collagen trimer|extracellular space|cytoplasm|,"cell migration|positive regulation of protein binding|positive regulation of osteoblast proliferation|ossification involved in bone remodeling|positive regulation of osteoblast differentiation|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor stereocilium organization|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|establishment of planar polarity involved in neural tube closure|",frizzled binding|Wnt-protein binding|,10,1,1.25,10,5.2,0.34,0.6,0.417,0.649,-2.4,9.3
ENSMUSG00000025746,IL6,interleukin 6,extracellular region|extracellular space|interleukin-6 receptor complex|external side of plasma membrane|,"neutrophil apoptotic process|hepatic immune response|hepatic immune response|neutrophil mediated immunity|monocyte chemotaxis|positive regulation of acute inflammatory response|positive regulation of leukocyte chemotaxis|negative regulation of protein kinase activity|acute-phase response|inflammatory response|humoral immune response|aging|positive regulation of cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|regulation of cell shape|response to heat|response to cold|response to mechanical stimulus|regulation of vascular endothelial growth factor production|negative regulation of lipid storage|cell growth|cytokine-mediated signaling pathway|platelet activation|response to caffeine|endocrine pancreas development|neuron projection development|response to nutrient levels|response to peptidoglycan|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|response to insulin|negative regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein import into nucleus, translocation|positive regulation of T cell proliferation|response to drug|positive regulation of tyrosine phosphorylation of Stat3 protein|defense response to protozoan|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to amino acid|positive regulation of MAPK cascade|negative regulation of chemokine biosynthetic process|regulation of circadian sleep/wake cycle, non-REM sleep|positive regulation of nitric oxide biosynthetic process|cell redox homeostasis|negative regulation of fat cell differentiation|positive regulation of T-helper 2 cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of gluconeogenesis|positive regulation of translation|positive regulation of DNA replication|regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JAK-STAT cascade|response to antibiotic|muscle cell cellular homeostasis|bone remodeling|negative regulation of hormone secretion|negative regulation of muscle organ development|positive regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|negative regulation of cytokine secretion|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of immunoglobulin secretion|positive regulation of sequence-specific DNA binding transcription factor activity|response to glucocorticoid|response to calcium ion|response to electrical stimulus|defense response to virus|positive regulation of protein kinase B signaling|positive regulation of transmission of nerve impulse|branching involved in salivary gland morphogenesis|epithelial cell proliferation involved in salivary gland morphogenesis|glucagon secretion|interleukin-6-mediated signaling pathway|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|T-helper 17 cell lineage commitment|negative regulation of neuron death|positive regulation of STAT protein import into nucleus|positive regulation of type B pancreatic cell apoptotic process|",cytokine activity|cytokine activity|interleukin-6 receptor binding|interleukin-6 receptor binding|interleukin-6 receptor binding|protein binding|growth factor activity|,10,6,3.05,10,-0.4,0.0695,5.9,0.416,0.65,-2.3,12.2
ENSMUSG00000028307,ALDOB,"aldolase B, fructose-bisphosphate",microtubule organizing center|cytosol|centriolar satellite|extracellular vesicular exosome|,"carbohydrate metabolic process|fructose metabolic process|fructose catabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|glycolytic process|NADH oxidation|fructose 1,6-bisphosphate metabolic process|positive regulation of ATPase activity|small molecule metabolic process|vacuolar proton-transporting V-type ATPase complex assembly|",fructose-bisphosphate aldolase activity|fructose-bisphosphate aldolase activity|protein binding|cytoskeletal protein binding|identical protein binding|ATPase binding|fructose binding|,10,-3.7,0.729,10,1.7,1.44,0.7,0.416,0.65,-8.7,6.9
ENSMUSG00000001131,TIMP1,TIMP metallopeptidase inhibitor 1,extracellular region|extracellular region|basement membrane|extracellular space|platelet alpha granule lumen|extracellular vesicular exosome|,platelet degranulation|aging|blood coagulation|positive regulation of cell proliferation|negative regulation of endopeptidase activity|extracellular matrix disassembly|platelet activation|extracellular matrix organization|response to cytokine|negative regulation of apoptotic process|response to peptide hormone|negative regulation of metalloenzyme activity|negative regulation of membrane protein ectodomain proteolysis|negative regulation of trophoblast cell migration|regulation of integrin-mediated signaling pathway|,protease binding|cytokine activity|protein binding|growth factor activity|metalloendopeptidase inhibitor activity|metal ion binding|,10,0,0,10,-1.2,1.09,-0.7,0.415,0.65,-4.5,2.4
ENSMUSG00000006784,TTC25,tetratricopeptide repeat domain 25,cytoplasm|,None,None,1,-1.1,0.453,0,0,0,-1.1,0.415,0.65,-2,1.8
ENSMUSG00000031841,CDH13,cadherin 13,extracellular space|cytoplasm|plasma membrane|plasma membrane|caveola|external side of plasma membrane|anchored component of membrane|neuron projection|perinuclear region of cytoplasm|extracellular vesicular exosome|,mitotic cell cycle|regulation of cell growth|positive regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|sprouting angiogenesis|homophilic cell adhesion|negative regulation of cell adhesion|Rho protein signal transduction|negative regulation of cell proliferation|calcium-dependent cell-cell adhesion|Rac protein signal transduction|lamellipodium assembly|regulation of endocytosis|positive regulation of cell migration|cell junction assembly|adherens junction organization|regulation of epidermal growth factor receptor signaling pathway|endothelial cell migration|keratinocyte proliferation|cell-cell junction organization|positive regulation of transcription from RNA polymerase II promoter|positive regulation of smooth muscle cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of positive chemotaxis|localization within membrane|low-density lipoprotein particle mediated signaling|,calcium ion binding|low-density lipoprotein particle binding|protein homodimerization activity|cadherin binding|adiponectin binding|lipoprotein particle binding|,10,-3.6,0.578,10,-0.9,0.906,-0.8,0.415,0.65,-9,2.4
ENSMUSG00000029106,ADD1,adducin 1 (alpha),nucleus|cytosol|plasma membrane|F-actin capping protein complex|postsynaptic density|dendritic spine|intermediate filament cytoskeleton|perinuclear region of cytoplasm|,cell morphogenesis|in utero embryonic development|cell volume homeostasis|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|activation of signaling protein activity involved in unfolded protein response|hemoglobin metabolic process|actin cytoskeleton organization|erythrocyte differentiation|endoplasmic reticulum unfolded protein response|positive regulation of protein binding|multicellular organism growth|cellular protein metabolic process|positive regulation of angiogenesis|positive regulation of endocytosis|homeostasis of number of cells within a tissue|barbed-end actin filament capping|actin filament bundle assembly|cellular response to retinoic acid|,actin binding|structural molecule activity|calmodulin binding|transcription factor binding|spectrin binding|T cell receptor binding|protein homodimerization activity|poly(A) RNA binding|protein heterodimerization activity|actin filament binding|,10,-5.4,1.18,10,0.1,0.00231,-0.5,0.414,0.651,-9.4,5.8
ENSMUSG00000004655,AQP1,aquaporin 1 (Colton blood group),nucleus|cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|brush border|basal plasma membrane|basolateral plasma membrane|apical plasma membrane|symbiont-containing vacuole|symbiont-containing vacuole membrane|brush border membrane|nuclear membrane|sarcolemma|apical part of cell|extracellular vesicular exosome|,renal water transport|cGMP biosynthetic process|potassium ion transport|water transport|water transport|water transport|cell volume homeostasis|carbon dioxide transport|ammonium transport|bicarbonate transport|glycerol transport|cellular homeostasis|lateral ventricle development|pancreatic juice secretion|nitric oxide transport|establishment or maintenance of actin cytoskeleton polarity|cerebrospinal fluid secretion|cellular response to stress|cellular response to UV|transepithelial water transport|carbon dioxide transmembrane transport|odontogenesis|response to drug|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|small molecule metabolic process|positive regulation of angiogenesis|positive regulation of saliva secretion|positive regulation of fibroblast proliferation|multicellular organismal water homeostasis|transmembrane transport|cellular response to hydrogen peroxide|cellular response to inorganic substance|cellular response to mechanical stimulus|cellular response to copper ion|cellular response to mercury ion|cellular response to retinoic acid|cellular response to cAMP|cellular response to cAMP|cellular response to hypoxia|cellular response to salt stress|cellular hyperosmotic response|cellular response to dexamethasone stimulus|cellular response to nitric oxide|potassium ion transmembrane transport|potassium ion transmembrane transport|ammonium transmembrane transport|maintenance of symbiont-containing vacuole by host|,intracellular cGMP activated cation channel activity|potassium channel activity|water transmembrane transporter activity|protein binding|ammonium transmembrane transporter activity|potassium ion transmembrane transporter activity|glycerol transmembrane transporter activity|water channel activity|water channel activity|water channel activity|transmembrane transporter activity|nitric oxide transmembrane transporter activity|carbon dioxide transmembrane transporter activity|carbon dioxide transmembrane transporter activity|,10,0,0,10,-0.7,0.541,-0.6,0.413,0.651,-4.9,2.6
ENSMUSG00000036093,ARL5A,ADP-ribosylation factor-like 5A,intracellular|,small GTPase mediated signal transduction|,GTP binding|,10,-0.1,0.0288,10,-1.2,1.03,-1,0.413,0.651,-7.9,2.8
ENSMUSG00000021615,XRCC4,X-ray repair complementing defective repair in Chinese hamster cells 4,nucleus|nucleus|nucleoplasm|centrosome|cytosol|DNA-dependent protein kinase-DNA ligase 4 complex|cell junction|DNA ligase IV complex|nonhomologous end joining complex|,in utero embryonic development|pro-B cell differentiation|DNA repair|double-strand break repair|double-strand break repair|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|central nervous system development|response to X-ray|response to gamma radiation|viral process|T cell differentiation in thymus|immunoglobulin V(D)J recombination|negative regulation of neuron apoptotic process|isotype switching|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|DNA ligation involved in DNA repair|positive regulation of ligase activity|cellular response to lithium ion|establishment of integrated proviral latency|,protein binding|protein C-terminus binding|,10,0.6,0.368,10,-0.5,0.138,0.6,0.412,0.651,-4.1,4.3
ENSMUSG00000056708,IER5,immediate early response 5,None,None,None,1,1.1,0.449,0,0,0,1.1,0.412,0.651,-1.7,3
ENSMUSG00000027339,RASSF2,Ras association (RalGDS/AF-6) domain family member 2,nucleus|cytoplasm|,cell cycle|signal transduction|,protein binding|,10,-2,0.96,10,-0.3,0.0901,-1.5,0.411,0.652,-7,3.4
ENSMUSG00000026502,DESI2,desumoylating isopeptidase 2,cytoplasm|,proteolysis|,peptidase activity|,0,0,0,3,-1,0.447,-1,0.411,0.652,-2,1.7
ENSMUSG00000011267,ZFP296,zinc finger protein 296,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1.8,0.447,-1.8,0.411,0.652,-3,1.7
ENSMUSG00000032109,NLRX1,NLR family member X1,mitochondrial outer membrane|,viral process|negative regulation of type I interferon production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|negative regulation of RIG-I signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of innate immune response|negative regulation of inflammatory response|,protein binding|ATP binding|,0,0,0,1,1.2,0.447,1.2,0.41,0.652,-1.7,3
ENSMUSG00000037979,CCDC92,coiled-coil domain containing 92,centriole|,None,protein binding|,0,0,0,1,1.2,0.447,1.2,0.41,0.652,-1.7,3
ENSMUSG00000090470,2410012M07RIK,RIKEN cDNA 2410012M07 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1.8,0.447,-1.8,0.41,0.652,-3,1.7
ENSMUSG00000043485,KRT34,keratin 34,extracellular space|intermediate filament|extracellular vesicular exosome|,epidermis development|,structural molecule activity|,0,0,0,1,1.2,0.447,1.2,0.41,0.652,-1.7,3
ENSMUSG00000001445,MRPL10,mitochondrial ribosomal protein L10,mitochondrion|mitochondrial large ribosomal subunit|ribonucleoprotein complex|,translation|ribosome biogenesis|,structural constituent of ribosome|poly(A) RNA binding|,0,0,0,1,1.2,0.447,1.2,0.41,0.652,-1.7,3
ENSMUSG00000024978,GPAM,"glycerol-3-phosphate acyltransferase, mitochondrial",mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|integral component of membrane|,fatty acid metabolic process|acyl-CoA metabolic process|phospholipid metabolic process|phosphatidic acid biosynthetic process|response to glucose|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|triglyceride biosynthetic process|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|cellular lipid metabolic process|small molecule metabolic process|glycerophospholipid biosynthetic process|regulation of cytokine secretion|defense response to virus|fatty acid homeostasis|phospholipid homeostasis|negative regulation of activation-induced cell death of T cells|interleukin-2 secretion|,glycerol-3-phosphate O-acyltransferase activity|,0,0,0,1,1.2,0.447,1.2,0.41,0.652,-1.7,3
ENSMUSG00000038170,PDE4DIP,phosphodiesterase 4D interacting protein,nucleus|cytoplasm|Golgi apparatus|centrosome|centrosome|myofibril|,cellular protein complex assembly|,protein binding|enzyme binding|,10,-0.5,0.385,10,-0.3,0.0649,-0.4,0.408,0.653,-4.1,2.1
ENSMUSG00000036136,FAM110C,"family with sequence similarity 110, member C",spindle pole|nucleus|microtubule organizing center|microtubule|cell cortex|,positive regulation of cell migration|positive regulation of protein kinase B signaling|regulation of cell projection assembly|,protein binding|alpha-tubulin binding|,10,1,1.26,10,0,0,0.7,0.407,0.654,-2.2,4
ENSMUSG00000030111,A2M,alpha-2-macroglobulin,extracellular region|extracellular region|cytosol|platelet alpha granule lumen|extracellular vesicular exosome|blood microparticle|,"negative regulation of complement activation, lectin pathway|platelet degranulation|small GTPase mediated signal transduction|blood coagulation|blood coagulation, intrinsic pathway|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|extracellular matrix disassembly|platelet activation|extracellular matrix organization|stem cell differentiation|regulation of small GTPase mediated signal transduction|",protease binding|serine-type endopeptidase inhibitor activity|receptor binding|protein binding|growth factor binding|enzyme binding|interleukin-8 binding|interleukin-1 binding|tumor necrosis factor binding|calcium-dependent protein binding|,10,-1.3,1.23,10,-0.1,0.00672,-1.1,0.407,0.654,-4.1,2.8
ENSMUSG00000003154,FOXJ2,forkhead box J2,nucleus|nucleus|nucleolus|,"transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding|,0,0,0,1,-1.7,0.442,-1.7,0.406,0.654,-3,1.7
ENSMUSG00000033540,IDUA,"iduronidase, alpha-L-",coated vesicle|lysosomal lumen|extracellular vesicular exosome|,cell morphogenesis|carbohydrate metabolic process|disaccharide metabolic process|glycosaminoglycan catabolic process|lysosome organization|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate catabolic process|dermatan sulfate catabolic process|limb morphogenesis|small molecule metabolic process|skeletal system morphogenesis|chemical homeostasis|,L-iduronidase activity|receptor binding|,10,0.9,1.15,10,-1.7,1.61,-1.2,0.406,0.654,-5.6,3.6
ENSMUSG00000068250,AMN1,antagonist of mitotic exit network 1 homolog (S. cerevisiae),None,None,None,0,0,0,1,-1.7,0.442,-1.7,0.406,0.654,-3,1.7
ENSMUSG00000052560,CPNE8,copine VIII,extracellular vesicular exosome|,None,None,10,-0.4,0.282,10,0.6,0.696,0.5,0.406,0.654,-8.6,5
ENSMUSG00000036840,SIAH1A,seven in absentia 1A,nucleus|cytoplasm|early endosome|cytosol|plasma membrane|beta-catenin destruction complex|,ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|male meiosis I|multicellular organismal development|spermatogenesis|post-embryonic development|protein ubiquitination|cell differentiation|protein catabolic process|protein destabilization|regulation of multicellular organism growth|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neuron apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|,"ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|protein C-terminus binding|zinc ion binding|zinc ion binding|UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity|ligase activity|ribosomal S6-glutamic acid ligase activity|protein homodimerization activity|coenzyme F420-0 gamma-glutamyl ligase activity|coenzyme F420-2 alpha-glutamyl ligase activity|metal ion binding|protein-glycine ligase activity|protein-glycine ligase activity, initiating|protein-glycine ligase activity, elongating|tubulin-glycine ligase activity|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|",0,0,0,1,-1.7,0.442,-1.7,0.406,0.654,-3,1.7
ENSMUSG00000030498,GAS2,growth arrest-specific 2,cytosol|actin filament|membrane|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|cell cycle arrest|regulation of cell shape|,None,10,0.2,0.00651,10,0.7,0.574,0.5,0.405,0.655,-3,3
ENSMUSG00000006373,PGRMC1,progesterone receptor membrane component 1,nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|extracellular vesicular exosome|,axon guidance|,steroid binding|protein binding|heme binding|,10,-0.8,0.426,10,2.4,0.199,-0.6,0.402,0.656,-7.2,5.8
ENSMUSG00000031826,USP10,ubiquitin specific peptidase 10,nucleus|cytoplasm|early endosome|intermediate filament cytoskeleton|,"DNA repair|ubiquitin-dependent protein catabolic process|autophagy|regulation of autophagy|protein deubiquitination|protein deubiquitination|DNA damage response, signal transduction by p53 class mediator|",p53 binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|ubiquitin-specific protease activity|protein binding|ion channel binding|poly(A) RNA binding|,9,-2.4,0.949,10,1.6,1.99,-2.2,0.401,0.656,-6.3,5.4
ENSMUSG00000048349,POU4F1,POU class 4 homeobox 1,nuclear chromatin|neuron projection|,negative regulation of transcription from RNA polymerase II promoter|suckling behavior|ventricular compact myocardium morphogenesis|transcription from RNA polymerase II promoter|axonogenesis|synapse assembly|mesoderm development|cell migration in hindbrain|trigeminal nerve development|central nervous system neuron differentiation|habenula development|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of transcription from RNA polymerase II promoter|neuron fate specification|sensory system development|peripheral nervous system neuron development|regulation of neurogenesis|proprioception involved in equilibrioception|innervation|,RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|,9,0,0,10,-0.5,0.7,-0.4,0.401,0.656,-6.9,2
ENSMUSG00000047126,CLTC,"clathrin, heavy chain (Hc)",mitochondrion|spindle|cytosol|plasma membrane|membrane|clathrin coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|clathrin-coated vesicle|clathrin-coated endocytic vesicle membrane|trans-Golgi network membrane|melanosome|protein complex|extracellular vesicular exosome|clathrin complex|,osteoblast differentiation|intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|mitotic nuclear division|antigen processing and presentation of exogenous peptide antigen via MHC class II|receptor internalization|transferrin transport|membrane organization|negative regulation of hyaluronan biosynthetic process|negative regulation of hyaluronan biosynthetic process|,double-stranded RNA binding|structural molecule activity|protein binding|protein kinase binding|clathrin light chain binding|poly(A) RNA binding|,10,0.5,0.388,10,0.7,0.0522,0.6,0.401,0.656,-5.2,5
ENSMUSG00000040760,APPL1,"adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1",nucleus|cytoplasm|cytosol|endosome membrane|endosome membrane|vesicle membrane|NuRD complex|early endosome membrane|extracellular vesicular exosome|,apoptotic process|cell cycle|signal transduction|cell proliferation|insulin receptor signaling pathway|regulation of apoptotic process|positive regulation of apoptotic process|regulation of glucose import|regulation of establishment of protein localization to plasma membrane|,protein binding|identical protein binding|protein kinase B binding|,10,-0.1,0.0192,10,-1.1,0.613,-0.4,0.401,0.656,-4.3,2
ENSMUSG00000063447,UBE2D2B,ubiquitin-conjugating enzyme E2D 2B,cellular_component|,protein K29-linked ubiquitination|protein K27-linked ubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|,nucleotide binding|ubiquitin-protein transferase activity|ATP binding|ligase activity|acid-amino acid ligase activity|,1,-0.7,0.227,1,-1.4,0.278,-1.1,0.397,0.658,-3,1.7
ENSMUSG00000032485,SCAP,SREBF chaperone,Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|ER to Golgi transport vesicle membrane|integral component of membrane|protein complex|,response to hypoxia|aging|cholesterol metabolic process|response to insulin|SREBP signaling pathway|regulation of fatty acid biosynthetic process|small molecule metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|,protein binding|protein complex binding|unfolded protein binding|,9,-0.1,0.00771,9,-0.9,0.665,-0.8,0.396,0.658,-7.5,2.5
ENSMUSG00000063177,KLK1B27,kallikrein 1-related peptidase b27,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,8,0.3,0.141,10,2.9,1.77,1.7,0.392,0.66,-2.9,7.2
ENSMUSG00000034457,EDA2R,ectodysplasin A2 receptor,integral component of plasma membrane|integral component of membrane|,epidermis development|embryo development|cell differentiation|tumor necrosis factor-mediated signaling pathway|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|,receptor activity|tumor necrosis factor-activated receptor activity|protein binding|,10,0,0,10,1,1.06,0.6,0.392,0.66,-1.5,4.2
ENSMUSG00000032407,U2SURP,U2 snRNP-associated SURP domain containing,nucleus|,RNA processing|,nucleotide binding|protein binding|poly(A) RNA binding|,9,-5.6,2.06,8,-1.3,0.863,-0.5,0.392,0.66,-10.4,3.3
ENSMUSG00000025892,GRIA4,"glutamate receptor, ionotropic, AMPA 4",plasma membrane|cell junction|dendrite|endocytic vesicle membrane|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|postsynaptic membrane|,"transport|glutamate receptor signaling pathway|synaptic transmission|ion transmembrane transport|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|",ionotropic glutamate receptor activity|alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|,10,-1.4,0.741,10,0,0,-0.6,0.391,0.66,-4.3,2.6
ENSMUSG00000020133,2310011J03RIK,RIKEN cDNA 2310011J03 gene,cellular_component|,biological_process|,molecular_function|,10,-0.6,0.474,10,0,0,-0.6,0.39,0.66,-4.7,1.7
ENSMUSG00000061762,TAC1,"tachykinin, precursor 1",extracellular region|extracellular space|plasma membrane|axon|neuronal cell body|,"positive regulation of acute inflammatory response|inflammatory response|positive regulation of cytosolic calcium ion concentration|tachykinin receptor signaling pathway|neuropeptide signaling pathway|cell-cell signaling|synaptic transmission|insemination|long-term memory|regulation of blood pressure|associative learning|detection of abiotic stimulus|response to hormone|negative regulation of heart rate|positive regulation of epithelial cell migration|sensory perception of pain|positive regulation of synaptic transmission, cholinergic|positive regulation of synaptic transmission, GABAergic|response to lipopolysaccharide|positive regulation of renal sodium excretion|response to morphine|positive regulation of action potential|positive regulation of ossification|positive regulation of saliva secretion|response to pain|positive regulation of lymphocyte proliferation|positive regulation of stress fiber assembly|positive regulation of corticosterone secretion|",protein binding|substance P receptor binding|,8,-0.3,0.0921,8,-2.5,0.682,-3,0.389,0.661,-10.6,2.1
ENSMUSG00000030838,USH1C,"Usher syndrome 1C (autosomal recessive, severe)",photoreceptor outer segment|photoreceptor inner segment|cytoplasm|cytosol|cytoskeleton|plasma membrane|stereocilium|apical part of cell|synapse|,G2/M transition of mitotic cell cycle|sensory perception of sound|parallel actin filament bundle assembly|inner ear morphogenesis|auditory receptor cell differentiation|photoreceptor cell maintenance|sensory perception of light stimulus|equilibrioception|,protein binding|spectrin binding|,10,1.5,1.22,10,0.1,0.027,0.7,0.389,0.661,-3.9,5.2
ENSMUSG00000024120,LRPPRC,leucine-rich pentatricopeptide repeat containing,condensed nuclear chromosome|nucleus|nuclear inner membrane|nuclear outer membrane|nucleoplasm|mitochondrion|mitochondrion|cytoskeleton|microtubule|membrane|ribonucleoprotein complex|mitochondrial nucleoid|perinuclear region of cytoplasm|,"negative regulation of mitochondrial RNA catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|mitochondrion transport along microtubule|mRNA transport|regulation of mitochondrial translation|",single-stranded DNA binding|RNA binding|protein binding|microtubule binding|poly(A) RNA binding|beta-tubulin binding|,10,0.8,0.769,10,0.1,0.00923,0.4,0.387,0.661,-4.5,5.4
ENSMUSG00000025231,SUFU,suppressor of fused homolog (Drosophila),nucleus|cytoplasm|cytoplasm|primary cilium|,"negative regulation of transcription from RNA polymerase II promoter|skeletal system development|neural tube closure|heart looping|regulation of transcription, DNA-templated|proteolysis|signal transduction|multicellular organismal development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|negative regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of sequence-specific DNA binding transcription factor activity|skin development|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|",transcription corepressor activity|signal transducer activity|protein binding|beta-catenin binding|transcription factor binding|protein kinase binding|,10,-0.4,0.182,10,-0.7,0.325,-0.5,0.387,0.661,-4.5,1.8
ENSMUSG00000047990,C2CD4A,C2 calcium-dependent domain containing 4A,nucleus|,None,None,0,0,0,1,-1.7,0.421,-1.7,0.386,0.662,-3,1.7
ENSMUSG00000046658,ZFP316,zinc finger protein 316,intracellular|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",nucleic acid binding|DNA binding|metal ion binding|,0,0,0,1,-1.7,0.421,-1.7,0.386,0.662,-3,1.7
ENSMUSG00000018916,CSF2,colony stimulating factor 2 (granulocyte-macrophage),extracellular region|extracellular space|,embryonic placenta development|immune response|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of interleukin-23 production|epithelial fluid transport|macrophage activation|positive regulation of tyrosine phosphorylation of Stat5 protein|myeloid dendritic cell differentiation|positive regulation of DNA replication|negative regulation of cytolysis|cellular response to lipopolysaccharide|positive regulation of podosome assembly|dendritic cell differentiation|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|protein binding|growth factor activity|,10,0.5,0.19,10,-0.9,0.886,-0.7,0.386,0.662,-7.4,2.7
ENSMUSG00000042558,ADPRHL2,ADP-ribosylhydrolase like 2,nucleus|mitochondrial matrix|,metabolic process|,poly(ADP-ribose) glycohydrolase activity|metal ion binding|,0,0,0,1,-1.7,0.421,-1.7,0.386,0.662,-3,1.7
ENSMUSG00000060703,CD302,CD302 molecule,microvillus|cell cortex|membrane|integral component of membrane|filopodium|,phagocytosis|,carbohydrate binding|,0,0,0,1,-1.7,0.421,-1.7,0.386,0.662,-3,1.7
ENSMUSG00000032098,TREH,trehalase (brush-border membrane glycoprotein),plasma membrane|anchored component of plasma membrane|extracellular vesicular exosome|,carbohydrate metabolic process|trehalose metabolic process|trehalose catabolic process|organ morphogenesis|polysaccharide digestion|small molecule metabolic process|,"alpha,alpha-trehalase activity|",10,-0.2,0.126,10,-0.6,0.363,-0.4,0.384,0.663,-7.6,6
ENSMUSG00000029623,PDAP1,PDGFA associated protein 1,None,signal transduction|cell proliferation|,poly(A) RNA binding|,10,-0.3,0.0589,10,-0.9,0.509,-0.6,0.383,0.663,-7.7,3
ENSMUSG00000016458,WT1,Wilms tumor 1,nucleus|nucleoplasm|cytoplasm|cytoplasm|cytoplasm|nuclear speck|,"negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|ureteric bud development|branching involved in ureteric bud morphogenesis|kidney development|regulation of organ formation|apoptotic DNA fragmentation|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|germ cell development|thorax and anterior abdomen determination|heart development|sex determination|negative regulation of cell proliferation|RNA splicing|gonad development|male gonad development|tissue development|negative regulation of translation|negative regulation of cell growth|adrenal gland development|male genitalia development|epithelial cell differentiation|glomerulus development|glomerular basement membrane development|adrenal cortex formation|camera-type eye development|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|mesenchymal to epithelial transition|positive regulation of heart growth|diaphragm development|cardiac muscle cell fate commitment|visceral serous pericardium development|cellular response to cAMP|cellular response to gonadotropin stimulus|metanephric mesenchyme development|glomerular visceral epithelial cell differentiation|glomerular visceral epithelial cell differentiation|posterior mesonephric tubule development|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of metanephric glomerular mesangial cell proliferation|positive regulation of male gonad development|negative regulation of female gonad development|positive regulation of metanephric ureteric bud development|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|RNA binding|protein binding|zinc ion binding|sequence-specific DNA binding|transcription regulatory region DNA binding|C2H2 zinc finger domain binding|,10,0.7,0.729,10,-0.9,0.259,0.5,0.381,0.664,-6.9,3.7
ENSMUSG00000021613,HAPLN1,hyaluronan and proteoglycan link protein 1,extracellular region|proteinaceous extracellular matrix|extracellular matrix|,cell adhesion|extracellular matrix organization|,hyaluronic acid binding|,10,-2.5,1.96,10,0,0,-0.5,0.381,0.664,-7.1,1.9
ENSMUSG00000036856,WNT4,"wingless-type MMTV integration site family, member 4",extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|,"branching involved in ureteric bud morphogenesis|kidney development|epithelial to mesenchymal transition|embryonic epithelial tube formation|liver development|androgen biosynthetic process|male gonad development|male gonad development|female gonad development|negative regulation of gene expression|negative regulation of steroid biosynthetic process|protein palmitoylation|regulation of cell-cell adhesion|neuron differentiation|female sex determination|adrenal gland development|negative regulation of cell migration|positive regulation of bone mineralization|positive regulation of Rho GTPase activity|positive regulation of aldosterone biosynthetic process|positive regulation of collagen biosynthetic process|immature T cell proliferation in thymus|non-canonical Wnt signaling pathway via MAPK cascade|negative regulation of fibroblast growth factor receptor signaling pathway|cell fate commitment|negative regulation of cell differentiation|positive regulation of osteoblast differentiation|positive regulation of meiosis|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|oocyte development|smooth muscle cell differentiation|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|canonical Wnt signaling pathway|somatotropin secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|mesenchymal to epithelial transition|tertiary branching involved in mammary gland duct morphogenesis|negative regulation of wound healing|mammary gland epithelium development|positive regulation of dermatome development|paramesonephric duct development|negative regulation of testicular blood vessel morphogenesis|cellular response to transforming growth factor beta stimulus|renal vesicle formation|renal vesicle induction|metanephric mesenchymal cell differentiation|mesonephric tubule development|metanephric nephron morphogenesis|establishment of protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of male gonad development|positive regulation of cortisol biosynthetic process|negative regulation of testosterone biosynthetic process|negative regulation of apoptotic signaling pathway|",transcription corepressor activity|frizzled binding|receptor agonist activity|,10,-0.9,0.386,10,1.6,0.718,-0.7,0.38,0.664,-4.1,5
ENSMUSG00000031613,HPGD,hydroxyprostaglandin dehydrogenase 15-(NAD),cytosol|cytosol|basolateral plasma membrane|extracellular vesicular exosome|,prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway|female pregnancy|parturition|arachidonic acid metabolic process|cyclooxygenase pathway|lipoxygenase pathway|ovulation|small molecule metabolic process|negative regulation of cell cycle|oxidation-reduction process|thrombin receptor signaling pathway|ductus arteriosus closure|lipoxin metabolic process|,catalytic activity|prostaglandin E receptor activity|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|protein homodimerization activity|NAD binding|NAD+ binding|,10,-1.1,1.34,10,0,0,-0.9,0.379,0.665,-3.2,1.6
ENSMUSG00000009741,UBP1,upstream binding protein 1 (LBP-1a),nucleus|,"angiogenesis|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|viral genome replication|negative regulation of transcription, DNA-templated|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|,10,0.3,0.115,10,0.9,0.448,0.4,0.378,0.665,-2.2,3
ENSMUSG00000079562,MAEA,macrophage erythroblast attacher,nucleus|spindle|actomyosin contractile ring|cytoskeleton|integral component of plasma membrane|nuclear matrix|,cytoskeleton organization|cell cycle|cell adhesion|regulation of mitotic cell cycle|negative regulation of myeloid cell apoptotic process|erythrocyte maturation|enucleate erythrocyte development|cell division|,actin binding|,9,-0.9,0.595,9,1.5,0.824,-0.8,0.377,0.665,-3.2,3.3
ENSMUSG00000059857,NTNG1,netrin G1,anchored component of plasma membrane|,axonogenesis|,protein binding|,10,-3.1,0.778,10,-0.1,0.0129,-2.8,0.376,0.666,-9.8,4
ENSMUSG00000066640,FBXL18,F-box and leucine-rich repeat protein 18,None,None,None,10,-0.4,0.227,10,-2.1,1.17,-0.9,0.374,0.666,-6,2.3
ENSMUSG00000038146,NOTCH3,notch 3,Golgi membrane|extracellular region|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|actin cytoskeleton|integral component of membrane|receptor complex|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|Notch receptor processing|gene expression|forebrain development|negative regulation of neuron differentiation|positive regulation of smooth muscle cell proliferation|neuron fate commitment|glomerular capillary formation|",calcium ion binding|protein binding|enzyme binding|,10,-0.2,0.0602,10,-0.7,0.486,-0.4,0.373,0.667,-4.3,2.7
ENSMUSG00000022510,TRP63,transformation related protein 63,chromatin|nuclear chromatin|intracellular|nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|rough endoplasmic reticulum|cytosol|dendrite|dendrite|neuron projection|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|replicative cell aging|skeletal system development|establishment of planar polarity|morphogenesis of a polarized epithelium|hair follicle development|positive regulation of mesenchymal cell proliferation|epithelial cell development|epithelial cell development|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle|Notch signaling pathway|multicellular organismal development|pattern specification process|ectoderm and mesoderm interaction|cell aging|epidermis development|organ morphogenesis|proximal/distal pattern formation|response to X-ray|multicellular organismal aging|response to gamma radiation|epidermal cell division|regulation of epidermal cell division|positive regulation of keratinocyte proliferation|cell differentiation|keratinocyte differentiation|embryonic limb morphogenesis|embryonic limb morphogenesis|prostate gland development|epithelial cell differentiation|polarized epithelial cell differentiation|hair follicle morphogenesis|mitotic G1 DNA damage checkpoint|cellular response to UV|post-anal tail morphogenesis|odontogenesis of dentin-containing tooth|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|regulation of neuron apoptotic process|skin morphogenesis|keratinocyte proliferation|negative regulation of keratinocyte differentiation|negative regulation of keratinocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|sympathetic nervous system development|anatomical structure formation involved in morphogenesis|smooth muscle tissue development|female genitalia morphogenesis|protein tetramerization|protein homotetramerization|neuron apoptotic process|urinary bladder development|cloacal septation|prostatic bud formation|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|establishment of skin barrier|positive regulation of cell cycle G1/S phase transition|positive regulation of fibroblast apoptotic process|negative regulation of mesoderm development|negative regulation of cellular senescence|regulation of RNA biosynthetic process|positive regulation of apoptotic signaling pathway|",transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|p53 binding|DNA binding|chromatin binding|chromatin binding|damaged DNA binding|double-stranded DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|protein domain specific binding|identical protein binding|identical protein binding|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding|WW domain binding|,10,-0.6,0.084,10,1,0.907,0.6,0.371,0.668,-3.4,5
ENSMUSG00000066677,PYDC3,pyrin domain containing 3,nucleus|nucleolus|cytoplasm|membrane|,biological_process|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,10,-0.9,0.879,10,0.8,1.09,0.5,0.37,0.668,-2.7,2.8
ENSMUSG00000034891,SNCB,"synuclein, beta",nucleus|cytoplasm|mitochondrion|Golgi apparatus|growth cone|neuronal cell body|terminal bouton|,synaptic transmission|dopamine metabolic process|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|synapse organization|,phospholipase inhibitor activity|calcium ion binding|alpha-tubulin binding|beta-tubulin binding|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000030768,DISP1,dispatched homolog 1 (Drosophila),integral component of membrane|,smoothened signaling pathway|smoothened signaling pathway|patched ligand maturation|determination of left/right symmetry|embryonic pattern specification|dorsal/ventral pattern formation|peptide transport|diaphragm development|,hedgehog receptor activity|peptide transporter activity|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000020415,PTTG1,pituitary tumor-transforming 1,nucleus|cytoplasm|cytosol|,"mitotic cell cycle|DNA repair|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|chromosome segregation|mitotic nuclear division|spermatogenesis|negative regulation of endopeptidase activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|chromosome organization|",sequence-specific DNA binding transcription factor activity|cysteine-type endopeptidase inhibitor activity|protein binding|SH3 domain binding|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000026798,COQ4,coenzyme Q4,mitochondrion|mitochondrial inner membrane|,ubiquinone biosynthetic process|,None,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000075289,CARNS1,carnosine synthase 1,cellular_component|,ATP catabolic process|carnosine biosynthetic process|,ATP binding|ATPase activity|metal ion binding|carnosine synthase activity|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000020788,ATP2A3,"ATPase, Ca++ transporting, ubiquitous",endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sarcoplasmic reticulum|platelet dense tubular network membrane|nuclear membrane|sarcoplasmic reticulum membrane|,transport|calcium ion transport|blood coagulation|metabolic process|ion transmembrane transport|transmembrane transport|calcium ion transmembrane transport|calcium ion transmembrane transport|,calcium-transporting ATPase activity|ATP binding|metal ion binding|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000077450,RAB11B,"RAB11B, member RAS oncogene family",mitochondrion|synaptic vesicle|cell junction|phagocytic vesicle membrane|synaptic vesicle membrane|phagocytic vesicle|recycling endosome|recycling endosome membrane|extracellular vesicular exosome|,"receptor recycling|GTP catabolic process|GTP catabolic process|small GTPase mediated signal transduction|melanosome transport|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|regulation of anion transport|constitutive secretory pathway|regulated secretory pathway|cellular response to acidity|retrograde transport, endosome to plasma membrane|regulation of protein localization to cell surface|regulation of endocytic recycling|",GTPase activity|protein binding|GTP binding|GDP binding|,0,0,0,1,1.1,0.403,1.1,0.37,0.668,-1.8,2
ENSMUSG00000021944,GATA4,GATA binding protein 4,nucleus|nucleus|nucleus|nucleoplasm|,"in utero embryonic development|gastrulation with mouth forming second|endoderm formation|heart looping|atrioventricular valve morphogenesis|endocardial cushion development|endocardial cushion development|cardiac ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|ventricular septum development|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cell-cell signaling|spermatogenesis|endoderm development|blood coagulation|male gonad development|male gonad development|response to mechanical stimulus|negative regulation of autophagy|positive regulation vascular endothelial growth factor production|cardiac muscle hypertrophy in response to stress|signal transduction involved in regulation of gene expression|BMP signaling pathway|positive regulation of BMP signaling pathway|embryonic heart tube anterior/posterior pattern specification|response to drug|response to estrogen|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract morphogenesis|embryonic foregut morphogenesis|positive regulation of cardioblast differentiation|Sertoli cell differentiation|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|SMAD protein signal transduction|atrial septum morphogenesis|lung lobe formation|intestinal epithelial cell differentiation|cell growth involved in cardiac muscle cell development|cellular response to glucose stimulus|cellular response to follicle-stimulating hormone stimulus|epithelial cell fate commitment|seminiferous tubule development|regulation of cardiac muscle cell contraction|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity|enhancer sequence-specific DNA binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|transcription factor binding|zinc ion binding|activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|NFAT protein binding|co-SMAD binding|,10,-0.6,0.634,10,0,0,-0.4,0.368,0.669,-3.7,2.5
ENSMUSG00000037440,VNN1,vanin 1,plasma membrane|integral component of membrane|anchored component of membrane|extracellular vesicular exosome|,acute inflammatory response|chronic inflammatory response|cellular component movement|inflammatory response|response to oxidative stress|pantothenate metabolic process|single organismal cell-cell adhesion|positive regulation of T cell differentiation in thymus|innate immune response|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|,pantetheine hydrolase activity|GPI anchor binding|,10,2.9,2.83,10,-0.7,0.184,-0.9,0.367,0.669,-4.4,6.9
ENSMUSG00000038848,YTHDF1,"YTH domain family, member 1",None,None,poly(A) RNA binding|N6-methyladenosine-containing RNA binding|,0,0,0,1,-1.7,0.399,-1.7,0.366,0.67,-3,1.7
ENSMUSG00000042510,AA986860,expressed sequence AA986860,cytoplasm|extracellular vesicular exosome|,biological_process|,molecular_function|,0,0,0,1,-1.7,0.399,-1.7,0.366,0.67,-3,1.7
ENSMUSG00000035967,DDX26B,DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B,None,None,None,0,0,0,1,-1.7,0.399,-1.7,0.366,0.67,-3,1.7
ENSMUSG00000094832,GM21846,N/A,None,None,None,0,0,0,1,-1.7,0.399,-1.7,0.366,0.67,-3,1.7
ENSMUSG00000024151,MSH2,mutS homolog 2,nuclear chromosome|membrane|MutSalpha complex|MutSbeta complex|,meiotic mismatch repair|in utero embryonic development|oxidative phosphorylation|ATP catabolic process|ATP catabolic process|ATP catabolic process|DNA repair|mismatch repair|mismatch repair|postreplication repair|double-strand break repair|meiotic gene conversion|cell cycle arrest|germ cell development|determination of adult lifespan|male gonad development|response to X-ray|response to X-ray|response to UV-B|response to UV-B|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|B cell mediated immunity|B cell differentiation|intra-S DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of neuron apoptotic process|maintenance of DNA repeat elements|negative regulation of reciprocal meiotic recombination|isotype switching|isotype switching|negative regulation of DNA recombination|negative regulation of DNA recombination|positive regulation of helicase activity|,magnesium ion binding|four-way junction DNA binding|Y-form DNA binding|heteroduplex DNA loop binding|double-strand/single-strand DNA junction binding|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|protein binding|ATP binding|protein C-terminus binding|DNA-dependent ATPase activity|ATPase activity|centromeric DNA binding|enzyme binding|protein kinase binding|mismatched DNA binding|guanine/thymine mispair binding|guanine/thymine mispair binding|dinucleotide insertion or deletion binding|single guanine insertion binding|single thymine insertion binding|dinucleotide repeat insertion binding|oxidized purine DNA binding|MutLalpha complex binding|protein homodimerization activity|ADP binding|,10,-0.3,0.0164,10,-1.4,0.816,-0.9,0.365,0.67,-5.5,2.3
ENSMUSG00000032126,HMBS,hydroxymethylbilane synthase,cytosol|,porphyrin-containing compound metabolic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|heme biosynthetic process|peptidyl-pyrromethane cofactor linkage|small molecule metabolic process|,hydroxymethylbilane synthase activity|hydroxymethylbilane synthase activity|,10,0,0,10,-1.3,1.22,-1,0.365,0.67,-5.5,1.6
ENSMUSG00000020811,WSCD1,WSC domain containing 1,integral component of membrane|,metabolic process|,sulfotransferase activity|,10,-1.2,0.574,10,-0.4,0.151,-0.9,0.363,0.671,-3.8,3.1
ENSMUSG00000067924,CXX1B,CAAX box 1B,cellular_component|,biological_process|,molecular_function|,9,0,0,10,2.2,2.4,1.5,0.361,0.672,-7,5.5
ENSMUSG00000067925,CXX1A,CAAX box 1A,cellular_component|,biological_process|,molecular_function|,9,0,0,10,2.2,2.4,1.5,0.361,0.672,-7,5.5
ENSMUSG00000002996,HBP1,HMG-box transcription factor 1,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle arrest|Wnt signaling pathway|positive regulation of potassium ion transport|",DNA binding|RNA binding|protein binding|,10,-0.7,0.661,10,0,0,-0.5,0.36,0.672,-4.7,3.1
ENSMUSG00000028034,FUBP1,far upstream element (FUSE) binding protein 1,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|positive regulation of gene expression|",single-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|poly(A) RNA binding|,0,0,0,1,-1.7,0.392,-1.7,0.359,0.673,-3,1.7
ENSMUSG00000028005,GUCY1B3,"guanylate cyclase 1, soluble, beta 3","cytoplasm|guanylate cyclase complex, soluble|intracellular membrane-bounded organelle|",cGMP biosynthetic process|nitric oxide mediated signal transduction|blood coagulation|blood circulation|,guanylate cyclase activity|receptor activity|GTP binding|heme binding|metal ion binding|protein heterodimerization activity|Hsp90 protein binding|,10,-1.1,0.412,10,0.6,0.111,0.7,0.359,0.673,-4.5,3.8
ENSMUSG00000006369,FBLN1,fibulin 1,extracellular region|extracellular region|proteinaceous extracellular matrix|basement membrane|extracellular space|extracellular matrix|extracellular vesicular exosome|,embryo implantation|positive regulation of peptidase activity|viral process|extracellular matrix organization|,extracellular matrix structural constituent|calcium ion binding|peptidase activator activity|,10,-1,0.969,10,0,0,-0.7,0.356,0.674,-4,2.3
ENSMUSG00000022505,EMP2,epithelial membrane protein 2,integral component of membrane|apical plasma membrane|,positive regulation of cell-matrix adhesion|cell proliferation|positive regulation of integrin-mediated signaling pathway|,integrin binding|,9,-1,0.529,9,3.8,0.549,-0.7,0.356,0.674,-5.8,8
ENSMUSG00000022286,GRHL2,grainyhead-like 2 (Drosophila),nucleus|,"in utero embryonic development|neural tube closure|transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|,1,0.5,0.106,1,1.1,0.356,0.9,0.355,0.674,-1.8,2
ENSMUSG00000036599,CHST12,carbohydrate (chondroitin 4) sulfotransferase 12,Golgi membrane|membrane|integral component of Golgi membrane|,carbohydrate metabolic process|carbohydrate biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|small molecule metabolic process|,chondroitin 4-sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate binding|,10,-1.5,1.44,10,0.4,0.0176,-0.5,0.354,0.675,-5.9,2.5
ENSMUSG00000020594,PUM2,pumilio RNA-binding family member 2,cytoplasm|cytoplasmic stress granule|nuclear membrane|perinuclear region of cytoplasm|,regulation of translation|stress granule assembly|,protein binding|poly(A) RNA binding|,9,0.1,0.0211,9,1.1,0.715,0.8,0.353,0.675,-6.6,5.7
ENSMUSG00000031673,CDH11,"cadherin 11, type 2, OB-cadherin (osteoblast)",cytoplasm|plasma membrane|integral component of membrane|extracellular vesicular exosome|,skeletal system development|ossification|cell adhesion|homophilic cell adhesion|corticospinal tract morphogenesis|cell junction assembly|adherens junction organization|cell-cell junction organization|,calcium ion binding|,10,5.4,1.66,10,-0.2,0.038,0.5,0.353,0.675,-6.9,10.6
ENSMUSG00000058135,GSTM1,glutathione S-transferase mu 1,cytoplasm|cytosol|,glutathione metabolic process|xenobiotic metabolic process|nitrobenzene metabolic process|xenobiotic catabolic process|small molecule metabolic process|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process|,glutathione transferase activity|enzyme binding|protein homodimerization activity|glutathione binding|,10,1,0.762,10,0,0,0.5,0.347,0.677,-3.3,5.5
ENSMUSG00000028840,ZFP593,zinc finger protein 593,nucleus|nucleolus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|",DNA binding|metal ion binding|,0,0,0,1,-1.6,0.377,-1.6,0.346,0.678,-3,1.7
ENSMUSG00000031448,ADPRHL1,ADP-ribosylhydrolase like 1,None,protein de-ADP-ribosylation|,magnesium ion binding|ADP-ribosylarginine hydrolase activity|,10,1,0.893,10,-0.4,0.113,-0.8,0.346,0.678,-4.8,3.5
ENSMUSG00000023075,AKIRIN1,akirin 1,nucleus|nuclear membrane|,None,None,0,0,0,1,-1.6,0.377,-1.6,0.346,0.678,-3,1.7
ENSMUSG00000039391,CCDC81,coiled-coil domain containing 81,None,None,None,0,0,0,1,-1.6,0.377,-1.6,0.346,0.678,-3,1.7
ENSMUSG00000046201,SCAF8,SR-related CTD-associated factor 8,nucleus|spliceosomal complex|nuclear matrix|,mRNA processing|RNA splicing|,nucleotide binding|RNA binding|RNA polymerase core enzyme binding|,0,0,0,1,-1.6,0.377,-1.6,0.346,0.678,-3,1.7
ENSMUSG00000005124,WISP1,WNT1 inducible signaling pathway protein 1,extracellular space|cytoplasm|,regulation of cell growth|cell adhesion|signal transduction|cell-cell signaling|Wnt signaling pathway|,insulin-like growth factor binding|,10,1.1,0.491,10,0,0,1,0.344,0.679,-6.3,5.3
ENSMUSG00000090812,SAMD15,sterile alpha motif domain containing 15,None,None,None,10,-0.1,0.0145,10,-1.3,1.05,-0.5,0.343,0.679,-5.2,3.3
ENSMUSG00000051469,ZFP191,zinc finger protein 191,nucleus|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|myelination|negative regulation of transcription, DNA-templated|",nucleic acid binding|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|metal ion binding|,10,1.4,1.65,10,0,0,1.2,0.343,0.679,-8.9,4.7
ENSMUSG00000040229,GPR34,G protein-coupled receptor 34,integral component of plasma membrane|,G-protein coupled receptor signaling pathway|,G-protein coupled receptor activity|,10,0.2,0.0295,10,0.4,0.355,0.4,0.342,0.68,-3.5,4.3
ENSMUSG00000033544,ANGPTL1,angiopoietin-like 1,extracellular space|extracellular vesicular exosome|,transmembrane receptor protein tyrosine kinase signaling pathway|,receptor binding|,10,-0.9,0.148,10,-0.5,0.271,-0.7,0.342,0.68,-4.4,4
ENSMUSG00000034563,CCPG1,cell cycle progression 1,integral component of membrane|,cell cycle|positive regulation of cell proliferation|positive regulation of cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of Rho guanyl-nucleotide exchange factor activity|,molecular_function|,9,3.6,0.47,9,-0.6,0.368,-0.5,0.341,0.68,-4.2,7.4
ENSMUSG00000041954,TNFRSF18,"tumor necrosis factor receptor superfamily, member 18",extracellular region|integral component of plasma membrane|external side of plasma membrane|,apoptotic process|signal transduction|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|,tumor necrosis factor-activated receptor activity|,10,0.5,0.267,10,0.3,0.113,0.5,0.341,0.68,-2.3,4.8
ENSMUSG00000055745,LDOC1L,"leucine zipper, down-regulated in cancer 1-like",None,None,None,10,-0.3,0.0366,10,-0.7,0.373,-0.6,0.34,0.681,-5,2.6
ENSMUSG00000091243,VGLL3,vestigial-like family member 3,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",None,1,-2,0.747,1,0.7,0.169,-1.8,0.338,0.681,-4,1.7
ENSMUSG00000037259,DZANK1,double zinc ribbon and ankyrin repeat domains 1,None,None,zinc ion binding|,10,4.3,1.77,10,-0.4,0.303,-0.6,0.336,0.682,-4.2,8.6
ENSMUSG00000030350,PRMT8,protein arginine methyltransferase 8,cytosol|plasma membrane|,"regulation of transcription, DNA-templated|histone methylation|peptidyl-arginine methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|histone arginine methylation|regulation of protein binding|histone H4-R3 methylation|",protein binding|histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|identical protein binding|protein homodimerization activity|histone methyltransferase activity (H4-R3 specific)|protein heterodimerization activity|,10,-0.7,0.648,10,0,0,-0.5,0.336,0.682,-9.6,2.4
ENSMUSG00000025597,KLHL4,kelch-like family member 4,cytoplasm|cytoskeleton|,biological_process|,molecular_function|actin binding|,10,0.6,0.315,10,0.3,0.135,0.4,0.335,0.682,-3.4,5
ENSMUSG00000036403,CEP135,centrosomal protein 135kDa,centrosome|centriole|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|centriole replication|centriole-centriole cohesion|,protein binding|protein C-terminus binding|,10,-0.5,0.191,10,-0.9,0.208,-0.5,0.333,0.683,-11.1,2
ENSMUSG00000004035,GSTM7,"glutathione S-transferase, mu 7",cytoplasm|sarcoplasmic reticulum|extracellular vesicular exosome|,glutathione metabolic process|metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|nitrobenzene metabolic process|xenobiotic catabolic process|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|cellular detoxification of nitrogen compound|cellular response to caffeine|,glutathione transferase activity|receptor binding|transferase activity|enzyme binding|protein homodimerization activity|glutathione binding|,10,0.6,0.703,10,0,0,0.4,0.331,0.684,-2.6,4.5
ENSMUSG00000017721,PIGT,"phosphatidylinositol glycan anchor biosynthesis, class T",endoplasmic reticulum membrane|membrane|cytoplasmic membrane-bounded vesicle|integral component of endoplasmic reticulum membrane|GPI-anchor transamidase complex|,C-terminal protein lipidation|attachment of GPI anchor to protein|neuron differentiation|post-translational protein modification|cellular protein metabolic process|neuron apoptotic process|,GPI-anchor transamidase activity|protein binding|,0,0,0,1,1.1,0.361,1.1,0.331,0.684,-1.8,2
ENSMUSG00000049134,NRAP,nebulin-related anchoring protein,fascia adherens|muscle tendon junction|myofibril|,biological_process|,actin binding|actin binding|zinc ion binding|vinculin binding|muscle alpha-actinin binding|,0,0,0,1,1.1,0.361,1.1,0.331,0.684,-1.8,2
ENSMUSG00000035949,FBXW2,F-box and WD repeat domain containing 2,None,cellular protein modification process|proteolysis|protein ubiquitination|,ubiquitin-protein transferase activity|protein binding|,10,-0.9,0.226,10,4.8,1.63,0.4,0.331,0.684,-2.3,8.6
ENSMUSG00000030276,TTLL3,"tubulin tyrosine ligase-like family, member 3",microtubule|cilium|axoneme|microtubule cytoskeleton|,protein polyglycylation|axoneme assembly|cilium assembly|,"protein-glycine ligase activity|protein-glycine ligase activity, initiating|",0,0,0,1,1.1,0.361,1.1,0.331,0.684,-1.8,2
ENSMUSG00000051177,PLCB1,"phospholipase C, beta 1 (phosphoinositide-specific)",nuclear chromatin|nucleus|cytoplasm|cytosol|nuclear speck|nuclear membrane|extracellular vesicular exosome|,"G2/M transition of mitotic cell cycle|signal transduction|G-protein coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|synaptic transmission|memory|regulation of G-protein coupled receptor protein signaling pathway|lipid catabolic process|cerebral cortex development|positive regulation of interleukin-12 production|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|positive regulation of embryonic development|positive regulation of GTPase activity|inositol phosphate metabolic process|small molecule metabolic process|fat cell differentiation|positive regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|phosphatidylinositol metabolic process|insulin-like growth factor receptor signaling pathway|positive regulation of developmental growth|activation of meiosis involved in egg activation|interleukin-1-mediated signaling pathway|regulation of fertilization|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of acrosome reaction|negative regulation of monocyte extravasation|positive regulation of CD24 biosynthetic process|","phosphatidylinositol phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity|GTPase activator activity|calcium ion binding|calmodulin binding|lamin binding|phosphatidylinositol-4,5-bisphosphate binding|enzyme binding|protein homodimerization activity|",10,-0.5,0.244,10,2.3,1.15,1.2,0.331,0.684,-4.3,6.3
ENSMUSG00000040978,GM11992,predicted gene 11992,cellular_component|,biological_process|,molecular_function|,1,-0.9,0.36,0,0,0,-0.9,0.33,0.684,-2,1.8
ENSMUSG00000030314,ATG7,autophagy related 7,pre-autophagosomal structure|cytoplasm|cytosol|axoneme|,mitochondrion degradation|liver development|cellular protein modification process|protein lipidation|C-terminal protein lipidation|cellular amino acid metabolic process|cellular response to nitrogen starvation|organelle organization|adult walking behavior|cellular response to starvation|post-embryonic development|positive regulation of autophagy|protein transport|positive regulation of macroautophagy|protein ubiquitination|protein ubiquitination|cerebellar Purkinje cell layer development|pyramidal neuron development|central nervous system neuron axonogenesis|cerebral cortex development|protein catabolic process|regulation of protein ubiquitination|positive regulation of protein modification process|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|positive regulation of apoptotic process|negative regulation of apoptotic process|late nucleophagy|positive regulation of protein catabolic process|neurological system process|cardiac muscle cell development|membrane fusion|cellular response to hyperoxia|,ubiquitin activating enzyme activity|protein binding|transcription factor binding|Atg12 activating enzyme activity|Atg12 activating enzyme activity|Atg8 activating enzyme|protein homodimerization activity|,10,0.5,0.263,10,-2.3,0.733,0.5,0.33,0.684,-6.5,3.1
ENSMUSG00000024909,EFEMP2,EGF containing fibulin-like extracellular matrix protein 2,extracellular region|basement membrane|membrane|extracellular vesicular exosome|,signal transduction|blood coagulation|extracellular matrix organization|,transmembrane signaling receptor activity|extracellular matrix structural constituent|calcium ion binding|protein binding|,10,-0.5,0.252,10,-0.3,0.13,-0.4,0.33,0.684,-4.3,3.3
ENSMUSG00000004268,EMG1,EMG1 N1-specific pseudouridine methyltransferase,nucleus|nucleolus|cytoplasm|,rRNA processing|rRNA methylation|ribosomal small subunit biogenesis|,RNA binding|rRNA binding|poly(A) RNA binding|rRNA (pseudouridine) methyltransferase activity|,1,-2,0.729,1,0.1,0.00872,-1.8,0.329,0.685,-4,1.6
ENSMUSG00000049717,LIG4,"ligase IV, DNA, ATP-dependent",condensed chromosome|nucleus|nucleoplasm|cytoplasm|plasma membrane|focal adhesion|DNA-dependent protein kinase-DNA ligase 4 complex|DNA-dependent protein kinase-DNA ligase 4 complex|DNA ligase IV complex|nonhomologous end joining complex|,"single strand break repair|in utero embryonic development|pro-B cell differentiation|DNA ligation|lagging strand elongation|DNA repair|nucleotide-excision repair, DNA gap filling|double-strand break repair|double-strand break repair|double-strand break repair|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|double-strand break repair via nonhomologous end joining|cell cycle|central nervous system development|cell proliferation|response to X-ray|response to gamma radiation|viral process|T cell differentiation in thymus|V(D)J recombination|immunoglobulin V(D)J recombination|T cell receptor V(D)J recombination|somatic stem cell maintenance|negative regulation of neuron apoptotic process|isotype switching|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA ligation involved in DNA repair|chromosome organization|cell division|neuron apoptotic process|cellular response to lithium ion|establishment of integrated proviral latency|",DNA binding|DNA ligase activity|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|protein C-terminus binding|ligase activity|metal ion binding|,10,0,0,10,-3.1,1.87,-2.1,0.328,0.685,-7.3,3
ENSMUSG00000045896,PAIP2B,poly(A) binding protein interacting protein 2B,cytoplasm|,negative regulation of translational initiation|,"translation repressor activity, nucleic acid binding|protein binding|",0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000022228,ZSCAN26,zinc finger and SCAN domain containing 26,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",nucleic acid binding|sequence-specific DNA binding transcription factor activity|metal ion binding|,0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000002346,SLC25A42,"solute carrier family 25, member 42",nucleus|mitochondrion|mitochondrial inner membrane|integral component of membrane|,metabolic process|ADP transport|ATP transport|coenzyme A transmembrane transport|AMP transport|,ATP transmembrane transporter activity|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|adenosine-diphosphatase activity|AMP transmembrane transporter activity|,0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000035215,LSM7,"LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)",spliceosomal complex|cytosol|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA processing|RNA splicing|gene expression|RNA metabolic process|mRNA metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|",protein binding|U6 snRNA binding|,0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000018927,CCL6,chemokine (C-C motif) ligand 6,extracellular region|extracellular space|,chemotaxis|immune response|cell chemotaxis|,cytokine activity|chemokine activity|,0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000064317,GM10146,"LSM7 homolog, U6 small nuclear RNA associated pseudogene",None,None,None,0,0,0,1,-1.6,0.356,-1.6,0.327,0.685,-3,1.7
ENSMUSG00000030050,GKN1,gastrokine 1,cellular_component|extracellular region|secretory granule|,digestion|positive regulation of cell proliferation|positive regulation of cell division|,molecular_function|growth factor activity|,0,0,0,2,1.1,0.357,1.1,0.327,0.685,-1.7,3
ENSMUSG00000074254,CYP2A4,"cytochrome P450, family 2, subfamily a, polypeptide 4",cytoplasmic microtubule|,oxidation-reduction process|,coumarin 7-hydroxylase activity|enzyme binding|heme binding|,10,-3,1.27,10,-0.3,0.106,-0.5,0.326,0.686,-6,1.9
ENSMUSG00000028402,MPDZ,multiple PDZ domain protein,cytoplasm|tight junction|postsynaptic density|apical plasma membrane|apicolateral plasma membrane|dendrite|cytoplasmic vesicle|Schmidt-Lanterman incisure|postsynaptic membrane|,cell adhesion|viral process|myelination|,protein binding|protein C-terminus binding|,10,-2.2,1.07,10,5.3,0.711,-0.5,0.326,0.686,-5.9,10.6
ENSMUSG00000024028,TFF2,trefoil factor 2,extracellular space|extracellular vesicular exosome|,digestion|positive regulation of cell proliferation|calcium-mediated signaling|regulation of cell migration|negative regulation of macrophage activation|negative regulation of inflammatory response|negative regulation of gastric acid secretion|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|,protein binding|CXCR4 chemokine receptor binding|,10,-2,0.418,9,0.7,0.257,-0.5,0.326,0.686,-7.8,3
ENSMUSG00000021222,DCAF4,DDB1 and CUL4 associated factor 4,Cul4-RING E3 ubiquitin ligase complex|,protein ubiquitination|protein ubiquitination|,None,10,-0.6,0.179,10,-0.7,0.191,-0.7,0.326,0.686,-4.6,3.3
ENSMUSG00000031523,DLC1,DLC1 Rho GTPase activating protein,nucleus|cytoplasm|cytosol|caveola|focal adhesion|,neural tube closure|heart morphogenesis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|small GTPase mediated signal transduction|negative regulation of cell proliferation|negative regulation of cell proliferation|regulation of cell shape|hindbrain morphogenesis|actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell migration|forebrain development|positive regulation of Rho GTPase activity|positive regulation of Rho GTPase activity|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|positive regulation of protein dephosphorylation|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|positive regulation of execution phase of apoptosis|,Rho GTPase activator activity|Rho GTPase activator activity|protein binding|lipid binding|SH2 domain binding|,9,-1.1,0.973,10,1.1,0.329,-0.7,0.324,0.687,-4.9,4.5
ENSMUSG00000038344,TXLNG,taxilin gamma,cytosol|nuclear membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|regulation of cell cycle process|regulation of bone mineralization|regulation of cell cycle|",syntaxin binding|protein heterodimerization activity|,10,5.2,2.87,10,-0.8,0.669,0.4,0.323,0.687,-3.3,11.2
ENSMUSG00000057455,RIT2,Ras-like without CAAX 2,nucleus|plasma membrane|,GTP catabolic process|signal transduction|small GTPase mediated signal transduction|small GTPase mediated signal transduction|synaptic transmission|neurotrophin TRK receptor signaling pathway|,GTPase activity|calmodulin binding|GTP binding|,10,3.5,1.91,10,-1,0.169,2.4,0.323,0.687,-5.2,8
ENSMUSG00000027876,REG4,"regenerating islet-derived family, member 4",extracellular region|cytoplasm|,None,heparin binding|mannan binding|,10,0.6,0.329,10,0.3,0.0808,0.5,0.322,0.688,-2.7,4.2
ENSMUSG00000028186,UOX,"urate oxidase, pseudogene",None,None,None,10,-0.4,0.163,10,-0.6,0.215,-0.5,0.322,0.688,-6.8,3
ENSMUSG00000031628,CASP3,"caspase 3, apoptosis-related cysteine peptidase",nucleus|nucleoplasm|cytosol|cytosol|plasma membrane|,B cell homeostasis|release of cytochrome c from mitochondria|apoptotic DNA fragmentation|proteolysis|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|cellular response to DNA damage stimulus|heart development|sensory perception of sound|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to oxidative stress|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|response to UV|response to wounding|extracellular matrix disassembly|neuron differentiation|extracellular matrix organization|keratinocyte differentiation|erythrocyte differentiation|erythrocyte differentiation|platelet formation|negative regulation of B cell proliferation|glial cell apoptotic process|response to tumor necrosis factor|hippo signaling|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|cell fate commitment|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of activated T cell proliferation|neurotrophin TRK receptor signaling pathway|neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|execution phase of apoptosis|execution phase of apoptosis|,aspartic-type endopeptidase activity|cysteine-type endopeptidase activity|cysteine-type endopeptidase activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|peptidase activity|cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activity involved in execution phase of apoptosis|,9,0.5,0.17,10,1.3,0.438,0.6,0.321,0.688,-3.9,7.1
ENSMUSG00000020752,RECQL5,RecQ protein-like 5,"nucleus|nucleoplasm|nucleolus|cytoplasm|cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nuclear membrane|",ATP catabolic process|DNA metabolic process|DNA replication|DNA repair|DNA recombination|mitotic nuclear division|DNA duplex unwinding|DNA duplex unwinding|DNA duplex unwinding|negative regulation of transcription elongation from RNA polymerase II promoter|chromosome separation|,RNA polymerase II core binding|nucleic acid binding|DNA helicase activity|DNA helicase activity|ATP binding|ATP-dependent helicase activity|,9,-4,0.0352,10,0.9,0.346,0.8,0.321,0.688,-6.4,4.8
ENSMUSG00000024073,BIRC6,baculoviral IAP repeat containing 6,spindle pole|endosome|trans-Golgi network|microtubule organizing center|membrane|midbody|,protein phosphorylation|apoptotic process|mitotic nuclear division|positive regulation of cell proliferation|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|protein ubiquitination|regulation of cytokinesis|regulation of cell proliferation|negative regulation of apoptotic process|negative regulation of apoptotic process|labyrinthine layer development|spongiotrophoblast layer development|negative regulation of extrinsic apoptotic signaling pathway|,ubiquitin-protein transferase activity|cysteine-type endopeptidase inhibitor activity|protein binding|acid-amino acid ligase activity|,10,-4.8,2.65,10,0,0,-2.3,0.32,0.689,-9.7,3.9
ENSMUSG00000008892,VDAC3,voltage-dependent anion channel 3,nucleus|mitochondrion|mitochondrial outer membrane|pore complex|extracellular vesicular exosome|,anion transport|adenine transport|regulation of anion transport|transmembrane transport|,nucleotide binding|voltage-gated anion channel activity|porin activity|,10,-3.2,0.818,10,-0.1,0.0157,-0.6,0.319,0.689,-8.6,3
ENSMUSG00000026012,CD28,CD28 molecule,cytosol|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|,positive regulation of inflammatory response to antigenic stimulus|humoral immune response|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|positive regulation of signal transduction|viral process|T cell costimulation|Fc-epsilon receptor signaling pathway|cytokine biosynthetic process|positive regulation of T cell proliferation|positive regulation of T cell proliferation|positive regulation of T cell proliferation|negative thymic T cell selection|regulatory T cell differentiation|positive regulation of viral genome replication|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|innate immune response|positive regulation of translation|positive regulation of mitosis|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of alpha-beta T cell proliferation|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of isotype switching to IgG isotypes|regulation of defense response to virus by virus|apoptotic signaling pathway|,protease binding|SH3/SH2 adaptor activity|protein binding|coreceptor activity|identical protein binding|,10,0.6,0.477,10,0,0,0.4,0.317,0.69,-2.7,6.8
ENSMUSG00000026141,COL19A1,"collagen, type XIX, alpha 1",extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen|,skeletal system development|cell adhesion|skeletal muscle tissue development|single organismal cell-cell adhesion|extracellular matrix disassembly|cell differentiation|extracellular matrix organization|extracellular matrix organization|collagen catabolic process|,"extracellular matrix structural constituent|protein binding, bridging|",9,-1.4,0.489,9,-0.3,0.118,-0.5,0.317,0.69,-4.3,2.2
ENSMUSG00000098789,JMJD7,jumonji domain containing 7,None,None,None,1,-1.5,0.634,1,0,0,-1.3,0.315,0.691,-3,1.7
ENSMUSG00000094443,GM4975,predicted gene 4975,None,None,None,10,-0.1,0.00529,9,-0.5,0.415,-0.4,0.314,0.691,-6.3,7.7
ENSMUSG00000032702,KANK1,KN motif and ankyrin repeat domains 1,nucleus|nucleus|cytoplasm|cytoplasm|ruffle membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of neuron projection development|positive regulation of Wnt signaling pathway|negative regulation of cell migration|negative regulation of actin filament polymerization|negative regulation of Rho protein signal transduction|positive regulation of catenin import into nucleus|negative regulation of insulin receptor signaling pathway|positive regulation of wound healing|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|regulation of establishment of cell polarity|negative regulation of lamellipodium morphogenesis|",protein binding|beta-catenin binding|,10,-0.8,0.187,10,-0.4,0.255,-0.4,0.313,0.692,-4.1,2.8
ENSMUSG00000020317,THEG,theg spermatid protein,nucleus|,multicellular organismal development|spermatogenesis|cell differentiation|chaperone-mediated protein complex assembly|,protein binding|,10,0,0,10,1.2,1.15,0.4,0.311,0.692,-2.8,3.9
ENSMUSG00000031310,ZMYM3,"zinc finger, MYM-type 3",nucleus|,cytoskeleton organization|multicellular organismal development|regulation of cell morphogenesis|,DNA binding|zinc ion binding|,10,0,0,10,1.1,1.07,0.5,0.31,0.693,-1.6,4
ENSMUSG00000025422,AGAP2,"ArfGAP with GTPase domain, ankyrin repeat and PH domain 2",nucleus|nucleus|nucleolus|mitochondrion|membrane|,small GTPase mediated signal transduction|axon guidance|protein transport|regulation of ARF GTPase activity|negative regulation of protein catabolic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|,protein binding|GTP binding|ARF GTPase activator activity|zinc ion binding|,10,0.4,0.122,10,-5.6,2.3,-0.4,0.31,0.693,-10.7,1.7
ENSMUSG00000030094,XPC,"xeroderma pigmentosum, complementation group C",nucleus|nucleoplasm|nucleolus|cytoplasm|plasma membrane|extracellular vesicular exosome|XPC complex|,"nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|DNA repair|nucleotide-excision repair|nucleotide-excision repair|response to UV-B|intra-S DNA damage checkpoint|response to drug|regulation of mitotic cell cycle phase transition|",heteroduplex DNA loop binding|bubble DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|,10,-5.4,1.28,10,-0.1,0.0187,-0.3,0.31,0.693,-9.7,4.5
ENSMUSG00000033900,MAP9,microtubule-associated protein 9,cytoplasm|spindle|microtubule|,cytokinesis|mitotic nuclear division|regulation of mitosis|spindle assembly|,None,10,-1,1.31,10,0,0,-0.5,0.31,0.693,-5.7,4.3
ENSMUSG00000033083,TBC1D4,"TBC1 domain family, member 4",cytoplasm|cytoplasmic vesicle membrane|extracellular vesicular exosome|,vesicle-mediated transport|negative regulation of vesicle fusion|positive regulation of Rab GTPase activity|cellular response to insulin stimulus|membrane organization|,Rab GTPase activator activity|,10,0.5,0.195,10,-0.5,0.346,-0.4,0.309,0.694,-3.8,7.1
ENSMUSG00000039488,CNTN5,contactin 5,cytoplasm|plasma membrane|anchored component of membrane|,cell adhesion|sensory perception of sound|,None,10,-0.4,0.023,10,0.9,0.846,0.5,0.308,0.694,-6.6,6
ENSMUSG00000038692,HOXB4,homeobox B4,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|morphogenesis of an epithelial sheet|transcription, DNA-templated|cell proliferation|anterior/posterior pattern specification|positive regulation of transcription from RNA polymerase II promoter|somatic stem cell division|spleen development|bone marrow development|embryonic skeletal system morphogenesis|definitive hemopoiesis|hematopoietic stem cell differentiation|positive regulation of stem cell differentiation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,1,-1.7,0.673,1,0,0,-1.5,0.308,0.694,-4,1.6
ENSMUSG00000068699,FLNC,"filamin C, gamma",cytoplasm|cytosol|cytoskeleton|plasma membrane|sarcoplasm|Z disc|sarcolemma|costamere|,cell junction assembly|muscle fiber development|,actin binding|protein binding|cytoskeletal protein binding|ankyrin binding|,10,-0.4,0.317,10,-0.2,0.0444,-0.3,0.307,0.694,-10,2
ENSMUSG00000001467,CYP51,"cytochrome P450, family 51",endoplasmic reticulum|membrane|membrane|integral component of membrane|intracellular membrane-bounded organelle|,"lipid metabolic process|steroid biosynthetic process|cholesterol biosynthetic process|steroid metabolic process|cholesterol metabolic process|sterol biosynthetic process|cholesterol biosynthetic process via 24,25-dihydrolanosterol|oxidation-reduction process|demethylation|demethylation|","monooxygenase activity|iron ion binding|sterol 14-demethylase activity|sterol 14-demethylase activity|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|metal ion binding|",10,-0.8,1.25,10,1.1,0.645,-0.5,0.307,0.694,-7.9,4
ENSMUSG00000015882,LCORL,ligand dependent nuclear receptor corepressor-like,nucleus|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|,DNA binding|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000029426,SCARB2,"scavenger receptor class B, member 2",lysosomal membrane|lysosomal membrane|membrane|integral component of membrane|lysosomal lumen|extracellular vesicular exosome|,protein targeting to lysosome|cell adhesion|,receptor activity|protein binding|enzyme binding|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000040025,YTHDF2,"YTH domain family, member 2",cytoplasmic mRNA processing body|,humoral immune response|regulation of mRNA stability|,poly(A) RNA binding|N6-methyladenosine-containing RNA binding|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000053004,HRH1,histamine receptor H1,plasma membrane|integral component of plasma membrane|,inflammatory response|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|memory|visual learning|positive regulation of inositol trisphosphate biosynthetic process|regulation of vascular permeability|positive regulation of vasoconstriction|inositol phosphate-mediated signaling|regulation of synaptic plasticity|eosinophil chemotaxis|cellular response to histamine|,G-protein coupled receptor activity|histamine receptor activity|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000021413,PRPF4B,pre-mRNA processing factor 4B,nucleus|chromosome|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|protein phosphorylation|RNA splicing|",protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|poly(A) RNA binding|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000037458,AZIN1,antizyme inhibitor 1,cytosol|,regulation of cellular amino acid metabolic process|polyamine biosynthetic process|cellular nitrogen compound metabolic process|negative regulation of protein catabolic process|positive regulation of catalytic activity|positive regulation of catalytic activity|negative regulation of catalytic activity|small molecule metabolic process|,catalytic activity|enzyme inhibitor activity|ornithine decarboxylase activator activity|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000057554,LGALS8,"lectin, galactoside-binding, soluble, 8",extracellular space|cytoplasm|membrane|extracellular vesicular exosome|,plasma cell differentiation|T cell costimulation|,protein binding|carbohydrate binding|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000071037,CAMKMT,calmodulin-lysine N-methyltransferase,nucleus|Golgi apparatus|,peptidyl-lysine methylation|,calmodulin-lysine N-methyltransferase activity|,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000036613,TSSC1,tumor suppressing subtransferable candidate 1,None,None,None,0,0,0,1,-1.6,0.334,-1.6,0.306,0.695,-3,1.7
ENSMUSG00000028602,TNFRSF8,"tumor necrosis factor receptor superfamily, member 8",cytoplasm|plasma membrane|integral component of membrane|extracellular vesicular exosome|,signal transduction|negative regulation of cell proliferation|tumor necrosis factor-mediated signaling pathway|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of apoptotic process|positive regulation of TRAIL biosynthetic process|cellular response to mechanical stimulus|,transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|,10,-1.2,0.363,10,0.8,0.672,0.4,0.304,0.695,-3.6,2.7
ENSMUSG00000032612,USP4,ubiquitin specific peptidase 4 (proto-oncogene),nucleus|cytoplasm|lysosome|plasma membrane|,ubiquitin-dependent protein catabolic process|protein deubiquitination|negative regulation of protein ubiquitination|regulation of protein stability|protein localization to cell surface|,ubiquitin thiolesterase activity|ubiquitin-specific protease activity|protein binding|adenosine receptor binding|identical protein binding|metal ion binding|,10,0,0,10,1.1,0.988,0.5,0.302,0.696,-2.7,3.6
ENSMUSG00000027940,TPM3,tropomyosin 3,stress fiber|podosome|cytosol|cytoskeleton|cytoskeleton|muscle thin filament tropomyosin|growth cone|cortical cytoskeleton|filamentous actin|cleavage furrow|extracellular vesicular exosome|,cellular component movement|muscle contraction|muscle filament sliding|,molecular_function|actin binding|,10,-4,1.76,10,0.5,0.234,-1.2,0.302,0.696,-7.6,3.3
ENSMUSG00000033880,LGALS3BP,"lectin, galactoside-binding, soluble, 3 binding protein",proteinaceous extracellular matrix|extracellular space|membrane|extracellular matrix|extracellular vesicular exosome|blood microparticle|,receptor-mediated endocytosis|receptor-mediated endocytosis|cellular defense response|cell adhesion|signal transduction|,scavenger receptor activity|,10,-0.8,0.592,10,0,0,-0.7,0.301,0.697,-4.2,2.8
ENSMUSG00000027962,VCAM1,vascular cell adhesion molecule 1,podosome|extracellular space|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|microvillus|external side of plasma membrane|cell surface|integral component of membrane|filopodium|sarcolemma|apical part of cell|extracellular vesicular exosome|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|,response to hypoxia|acute inflammatory response|chronic inflammatory response|cell adhesion|heterophilic cell-cell adhesion|leukocyte cell-cell adhesion|heart development|aging|response to nutrient|amine metabolic process|response to zinc ion|response to ionizing radiation|viral process|cytokine-mediated signaling pathway|membrane to membrane docking|B cell differentiation|extracellular matrix organization|response to lipopolysaccharide|response to nicotine|cellular response to vascular endothelial growth factor stimulus|positive regulation of T cell proliferation|response to ethanol|regulation of immune response|leukocyte tethering or rolling|oxidation-reduction process|cell chemotaxis|interferon-gamma-mediated signaling pathway|chorio-allantoic fusion|cellular response to glucose stimulus|cellular response to tumor necrosis factor|,integrin binding|integrin binding|primary amine oxidase activity|cell adhesion molecule binding|cell adhesion molecule binding|,10,-1.6,1.45,10,0,0,-0.7,0.3,0.697,-7.7,5.4
ENSMUSG00000025480,SYCE1,synaptonemal complex central element protein 1,central element|,synaptonemal complex assembly|,None,10,0.4,0.112,10,0.4,0.217,0.4,0.3,0.697,-2.7,4.3
ENSMUSG00000038181,CHPF2,chondroitin polymerizing factor 2,Golgi membrane|membrane|integral component of membrane|Golgi cisterna membrane|,carbohydrate metabolic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|,N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|,0,0,0,1,-1.5,0.328,-1.5,0.3,0.697,-3,1.7
ENSMUSG00000019699,AKT3,v-akt murine thymoma viral oncogene homolog 3,nucleus|cytoplasm|Golgi apparatus|plasma membrane|,mitochondrial genome maintenance|protein phosphorylation|signal transduction|,protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|,10,-1.7,0.215,10,-0.7,0.202,-1,0.3,0.697,-4.9,3.4
ENSMUSG00000024273,2700062C07RIK,RIKEN cDNA 2700062C07 gene,cellular_component|,biological_process|,molecular_function|,1,-0.9,0.326,0,0,0,-0.9,0.299,0.698,-2,1.8
ENSMUSG00000055717,SLAIN1,"SLAIN motif family, member 1",None,None,None,0,0,0,1,-1.5,0.326,-1.5,0.299,0.698,-3,1.7
ENSMUSG00000056947,MAB21L1,mab-21-like 1 (C. elegans),nucleus|,positive regulation of cell proliferation|anatomical structure morphogenesis|camera-type eye development|,None,10,0.8,0.936,10,0,0,0.5,0.298,0.698,-8.7,5
ENSMUSG00000030092,CNTN6,contactin 6,plasma membrane|anchored component of membrane|,cell adhesion|Notch signaling pathway|axon guidance|central nervous system development|,None,10,-3.4,0.587,10,2.1,1.55,0.9,0.298,0.698,-8.5,4.1
ENSMUSG00000079476,1700011M02RIK,RIKEN cDNA 1700011M02 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,2,-1.1,0.323,-1.1,0.296,0.699,-2,1.8
ENSMUSG00000021240,ABCD4,"ATP-binding cassette, sub-family D (ALD), member 4",peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|integral component of membrane|ATP-binding cassette (ABC) transporter complex|,ATP catabolic process|cobalamin metabolic process|transmembrane transport|,"ATP binding|ATPase activity, coupled to transmembrane movement of substances|",10,3.8,1.55,10,0.7,0.25,2.3,0.294,0.7,-2.7,8.1
ENSMUSG00000089945,GM20459,N/A,None,None,None,1,-1.5,0.618,1,0.1,0.0012,-1.3,0.294,0.7,-3,1.7
ENSMUSG00000024853,SF3B2,"splicing factor 3b, subunit 2, 145kDa",nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|catalytic step 2 spliceosome|,"mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA processing|RNA splicing|gene expression|viral process|",protein binding|poly(A) RNA binding|,10,-3.8,2.2,10,-0.5,0.152,-0.4,0.294,0.7,-9.2,7.4
ENSMUSG00000059049,FREM1,FRAS1 related extracellular matrix 1,basement membrane|integral component of membrane|,cell communication|cell-matrix adhesion|craniofacial suture morphogenesis|,carbohydrate binding|metal ion binding|,10,0.9,1.2,10,0,0,0.5,0.294,0.7,-2.7,5
ENSMUSG00000041642,KIF21B,kinesin family member 21B,cytoplasm|kinesin complex|microtubule|,microtubule-based movement|metabolic process|,microtubule motor activity|ATP binding|microtubule binding|,0,0,0,1,1,0.32,1,0.293,0.7,-1.8,2
ENSMUSG00000010914,PDHX,"pyruvate dehydrogenase complex, component X",mitochondrial matrix|,pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|cellular metabolic process|small molecule metabolic process|,"transferase activity, transferring acyl groups|",0,0,0,1,1,0.32,1,0.293,0.7,-1.8,2
ENSMUSG00000031954,CFDP1,craniofacial development protein 1,cellular_component|,cell adhesion|multicellular organismal development|biological_process|regulation of cell shape|regulation of cell proliferation|negative regulation of fibroblast apoptotic process|,molecular_function|,9,0,0,10,-1.5,1.51,-1.4,0.293,0.7,-6.4,2.6
ENSMUSG00000030346,RAD51AP1,RAD51 associated protein 1,nucleus|,double-strand break repair via homologous recombination|DNA repair|regulation of double-strand break repair via homologous recombination|cellular response to ionizing radiation|,double-stranded DNA binding|single-stranded DNA binding|RNA binding|protein binding|,10,-5.8,1.82,10,-0.8,0.474,-0.5,0.291,0.701,-11.1,4
ENSMUSG00000079492,GM11127,predicted gene 11127,None,None,None,10,-0.5,0.334,10,-0.2,0.0426,-0.3,0.29,0.701,-3.2,1.6
ENSMUSG00000037529,PRSS40,"protease, serine 40",extracellular region|cytoplasmic vesicle|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,0,0,10,0.8,0.595,0.5,0.289,0.702,-4.5,5.3
ENSMUSG00000023011,FAIM2,Fas apoptotic inhibitory molecule 2,integral component of membrane|cell junction|membrane raft|postsynaptic membrane|,apoptotic process|cerebellum development|cerebellar Purkinje cell layer development|cerebellar granular layer development|cerebellar Purkinje cell differentiation|negative regulation of apoptotic process|regulation of neuron apoptotic process|,None,8,-0.4,0.264,8,-0.3,0.0643,-0.3,0.288,0.702,-4.5,3.7
ENSMUSG00000039126,PRUNE2,prune homolog 2 (Drosophila),cytoplasm|,apoptotic process|metabolic process|,pyrophosphatase activity|metal ion binding|,10,0.9,0.614,10,-1.7,1.21,-0.7,0.288,0.702,-5.8,4.1
ENSMUSG00000030762,AQP8,aquaporin 8,plasma membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|apical part of cell|intracellular canaliculus|,transport|water transport|canalicular bile acid transport|transmembrane transport|cellular response to cAMP|,water channel activity|,0,0,0,1,-1.5,0.314,-1.5,0.287,0.702,-3,1.7
ENSMUSG00000032271,NNMT,nicotinamide N-methyltransferase,cytosol|,xenobiotic metabolic process|response to organonitrogen compound|organ regeneration|methylation|response to drug|small molecule metabolic process|,nicotinamide N-methyltransferase activity|,0,0,0,1,-1.5,0.314,-1.5,0.287,0.702,-3,1.7
ENSMUSG00000032042,SRPR,signal recognition particle receptor (docking protein),endoplasmic reticulum|signal recognition particle receptor complex|endoplasmic reticulum membrane|membrane|integral component of membrane|extracellular vesicular exosome|,GTP catabolic process|translation|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|activation of signaling protein activity involved in unfolded protein response|gene expression|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|,GTPase activity|signal recognition particle binding|GTP binding|poly(A) RNA binding|,0,0,0,1,-1.5,0.314,-1.5,0.287,0.702,-3,1.7
ENSMUSG00000037965,ZC3H7A,zinc finger CCCH-type containing 7A,nucleus|,None,poly(A) RNA binding|metal ion binding|,0,0,0,1,-1.5,0.314,-1.5,0.287,0.702,-3,1.7
ENSMUSG00000069038,GM4906,predicted gene 4906,nucleosome|cellular_component|nucleus|chromosome|,biological_process|,molecular_function|DNA binding|,0,0,0,1,-1.5,0.314,-1.5,0.287,0.702,-3,1.7
ENSMUSG00000042870,TOM1,target of myb1 (chicken),cytoplasm|endosome|early endosome|cytosol|membrane|extracellular vesicular exosome|,intracellular protein transport|endocytosis|protein transport|endosomal transport|endosomal transport|,protein binding|clathrin binding|,10,-2.3,1.43,10,2.1,0.205,-0.7,0.284,0.704,-7.9,5.4
ENSMUSG00000032839,TRPC1,"transient receptor potential cation channel, subfamily C, member 1",plasma membrane|plasma membrane|integral component of plasma membrane|basolateral plasma membrane|sarcomere|costamere|receptor complex|membrane raft|,calcium ion transport|axon guidance|ion transmembrane transport|saliva secretion|positive regulation of release of sequestered calcium ion into cytosol|cytosolic calcium ion homeostasis|response to calcium ion|transmembrane transport|calcium ion transmembrane transport|,"cation channel activity|calcium channel activity|protein binding|store-operated calcium channel activity|ion channel binding|inositol 1,4,5 trisphosphate binding|",10,-5.6,1.48,10,0.9,0.492,0.5,0.284,0.704,-9.5,5
ENSMUSG00000066152,SLC31A2,"solute carrier family 31 (copper transporter), member 2",integral component of plasma membrane|,copper ion transport|copper ion transmembrane transport|,copper ion transmembrane transporter activity|,0,0,0,1,-1.5,0.308,-1.5,0.282,0.705,-3,1.7
ENSMUSG00000017801,MLX,"MLX, MAX dimerization protein",nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|energy reserve metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|positive regulation of cellular metabolic process|small molecule metabolic process|negative regulation of transcription, DNA-templated|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|protein homodimerization activity|protein heterodimerization activity|,10,0.5,0.284,10,0.2,0.0387,0.5,0.28,0.706,-4.8,4.9
ENSMUSG00000028497,PTPLAD2,protein tyrosine phosphatase-like A domain containing 2,endoplasmic reticulum membrane|integral component of membrane|,fatty acid biosynthetic process|,lyase activity|,10,0.7,0.297,10,0.4,0.0255,0.5,0.28,0.706,-2.4,3.8
ENSMUSG00000026418,TNNI1,"troponin I type 1 (skeletal, slow)",cytosol|troponin complex|,regulation of striated muscle contraction|muscle filament sliding|ventricular cardiac muscle tissue morphogenesis|,actin binding|metal ion binding|,10,-0.6,0.135,10,0.7,0.485,-0.6,0.28,0.706,-3.8,3.2
ENSMUSG00000018263,TBX5,T-box 5,nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytoplasm|,"morphogenesis of an epithelium|bundle of His development|atrioventricular valve morphogenesis|endocardial cushion development|cardiac left ventricle formation|ventricular cardiac muscle tissue development|ventricular septum development|transcription initiation from RNA polymerase II promoter|cell-cell signaling|pattern specification process|heart development|heart development|negative regulation of cell proliferation|gene expression|negative regulation of epithelial to mesenchymal transition|apoptotic nuclear changes|lung development|embryonic limb morphogenesis|negative regulation of cell migration|embryonic forelimb morphogenesis|forelimb morphogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|pericardium development|negative regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|atrial septum morphogenesis|cell migration involved in coronary vasculogenesis|positive regulation of secondary heart field cardioblast proliferation|regulation of execution phase of apoptosis|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|sequence-specific DNA binding|,10,0.6,0.486,10,-0.8,0.0463,0.5,0.28,0.706,-3.4,3.6
ENSMUSG00000016308,UBE2A,ubiquitin-conjugating enzyme E2A,chromatin|nuclear chromatin|XY body|cytosol|HULC complex|,protein polyubiquitination|in utero embryonic development|antigen processing and presentation of peptide antigen via MHC class I|DNA repair|postreplication repair|ubiquitin-dependent protein catabolic process|positive regulation of cell proliferation|response to UV|histone H2A ubiquitination|protein autoubiquitination|maternal process involved in female pregnancy|protein K48-linked ubiquitination|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|ubiquitin protein ligase binding|,10,-0.3,0.128,10,-0.6,0.26,-0.4,0.277,0.707,-9.4,3.8
ENSMUSG00000030403,VASP,vasodilator-stimulated phosphoprotein,cytoplasm|cytosol|plasma membrane|tight junction|focal adhesion|actin cytoskeleton|lamellipodium membrane|filopodium membrane|extracellular vesicular exosome|,neural tube closure|axon guidance|actin polymerization or depolymerization|positive regulation of actin filament polymerization|cell junction assembly|T cell receptor signaling pathway|protein homotetramerization|,actin binding|protein binding|profilin binding|SH3 domain binding|,10,-0.1,0.0122,10,-0.6,0.4,-0.3,0.276,0.707,-4.1,2.9
ENSMUSG00000029009,MTHFR,methylenetetrahydrofolate reductase (NAD(P)H),cytosol|neuron projection|,response to hypoxia|cellular amino acid metabolic process|vitamin metabolic process|water-soluble vitamin metabolic process|blood circulation|methionine biosynthetic process|response to vitamin B2|tetrahydrofolate interconversion|response to drug|small molecule metabolic process|S-adenosylmethionine metabolic process|folic acid metabolic process|homocysteine metabolic process|response to folic acid|oxidation-reduction process|response to interleukin-1|,methylenetetrahydrofolate reductase (NAD(P)H) activity|flavin adenine dinucleotide binding|NADP binding|modified amino acid binding|,10,0,0,10,-1,0.358,-1,0.276,0.707,-7.7,6.2
ENSMUSG00000049176,FRMPD4,FERM and PDZ domain containing 4,cytoskeleton|dendritic spine|,positive regulation of synapse structural plasticity|,"protein binding|phosphatidylinositol-4,5-bisphosphate binding|",9,-0.6,0.228,10,-0.6,0.0731,-0.6,0.275,0.708,-6.1,3.4
ENSMUSG00000032532,CCK,cholecystokinin,extracellular region|extracellular space|axon|dendrite|axon initial segment|terminal bouton|axon hillock|perikaryon|,behavioral fear response|neuron migration|release of cytochrome c from mitochondria|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|protein kinase C-activating G-protein coupled receptor signaling pathway|axonogenesis|positive regulation of cell proliferation|negative regulation of appetite|positive regulation of protein oligomerization|eating behavior|positive regulation of apoptotic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of mitochondrial depolarization|regulation of sensory perception of pain|,hormone activity|neuropeptide hormone activity|protein binding|,10,-0.7,0.882,10,0,0,-0.5,0.275,0.708,-4,2.3
ENSMUSG00000029838,PTN,pleiotrophin,extracellular space|endoplasmic reticulum|,transmembrane receptor protein tyrosine phosphatase signaling pathway|nervous system development|learning|positive regulation of cell proliferation|bone mineralization|negative regulation of catalytic activity|positive regulation of cell division|,protein phosphatase inhibitor activity|growth factor activity|heparin binding|,10,0,0,10,-0.6,0.584,-0.4,0.274,0.708,-4.2,2
ENSMUSG00000038526,CAR14,carbonic anhydrase 14,membrane|integral component of membrane|,regulation of pH|carbon dioxide transport|,carbonate dehydratase activity|carbonate dehydratase activity|lyase activity|metal ion binding|,10,-0.4,0.0203,10,-2.7,0.958,-0.4,0.273,0.709,-7.7,4.5
ENSMUSG00000004562,ARHGEF40,Rho guanine nucleotide exchange factor (GEF) 40,cytoplasm|,positive regulation of Rho GTPase activity|,Rho guanyl-nucleotide exchange factor activity|,10,-2.1,0.792,10,0.3,0.0279,-0.3,0.271,0.71,-4.6,4
ENSMUSG00000056267,CEP70,centrosomal protein 70kDa,nucleus|cytoplasm|centrosome|cytosol|nuclear membrane|,G2/M transition of mitotic cell cycle|mitotic cell cycle|,protein binding|,10,-1.5,0.124,10,-0.9,0.28,-1.1,0.27,0.71,-5.6,1.6
ENSMUSG00000045967,GPR158,G protein-coupled receptor 158,plasma membrane|integral component of membrane|,G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|protein localization to plasma membrane|,G-protein coupled receptor activity|,10,0,0,10,-1.6,1.56,-1.3,0.27,0.71,-6.2,2.2
ENSMUSG00000095440,FIGNL2,fidgetin-like 2,None,metabolic process|,ATP binding|nucleoside-triphosphatase activity|,0,0,0,1,-1.5,0.293,-1.5,0.268,0.711,-3,1.7
ENSMUSG00000024293,ESCO1,establishment of sister chromatid cohesion N-acetyltransferase 1,chromatin|nucleoplasm|,mitotic cell cycle|regulation of DNA replication|sister chromatid cohesion|post-translational protein acetylation|,"transferase activity, transferring acyl groups|metal ion binding|",10,1.3,1.53,10,0,0,0.8,0.267,0.711,-7.6,5
ENSMUSG00000033819,PPP1R16A,"protein phosphatase 1, regulatory subunit 16A",plasma membrane|,None,protein binding|,10,-1.2,1.05,10,0,0,-0.4,0.266,0.712,-5.5,2.3
ENSMUSG00000038843,GCNT1,"glucosaminyl (N-acetyl) transferase 1, core 2",Golgi membrane|extracellular space|trans-Golgi network|integral component of membrane|Golgi cisterna|,glycoprotein biosynthetic process|O-glycan processing|response to insulin|post-translational protein modification|cellular protein metabolic process|tissue morphogenesis|leukocyte tethering or rolling|cell adhesion molecule production|kidney morphogenesis|,"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|protein binding|",10,-0.1,0.0215,10,2.3,2.16,2,0.266,0.712,-2.8,8.9
ENSMUSG00000021115,VRK1,vaccinia related kinase 1,nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi stack|spindle|cytosol|,mitotic cell cycle|protein phosphorylation|mitotic nuclear division|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|histone H3-S10 phosphorylation|protein autophosphorylation|histone H3-T3 phosphorylation|Golgi disassembly|,protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleosomal histone binding|histone kinase activity (H3-S10 specific)|histone kinase activity (H3-T3 specific)|,10,-0.6,0.272,10,-0.3,0.0409,-0.4,0.264,0.712,-7.4,4.3
ENSMUSG00000020176,GRB10,growth factor receptor-bound protein 10,cytoplasm|cytosol|plasma membrane|,insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of Wnt signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|response to insulin|negative regulation of phosphorylation|positive regulation of phosphorylation|positive regulation of phosphorylation|negative regulation of glycogen biosynthetic process|negative regulation of glycogen biosynthetic process|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|,SH3/SH2 adaptor activity|insulin receptor binding|protein binding|,10,-0.6,0.508,10,0.5,0.213,-0.7,0.264,0.712,-5.2,4.7
ENSMUSG00000033813,TCEA1,"transcription elongation factor A (SII), 1",nucleus|nucleoplasm|nucleolus|,"DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|erythrocyte differentiation|regulation of DNA-templated transcription, elongation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|",DNA binding|protein binding|zinc ion binding|,10,-0.5,0.389,10,0,0,-0.4,0.264,0.712,-3.3,2.2
ENSMUSG00000022849,HSPBAP1,HSPB (heat shock 27kDa) associated protein 1,cytoplasm|,None,None,10,0.7,0.433,10,0,0,0.6,0.264,0.712,-3.9,6.2
ENSMUSG00000037013,SS18,"synovial sarcoma translocation, chromosome 18",nucleus|cytoplasmic microtubule|,"microtubule cytoskeleton organization|cell morphogenesis|transcription, DNA-templated|response to drug|positive regulation of transcription from RNA polymerase II promoter|ephrin receptor signaling pathway|",protein binding|ligand-dependent nuclear receptor transcription coactivator activity|,10,-0.4,0.0614,10,-0.6,0.238,-0.6,0.261,0.714,-3,2.2
ENSMUSG00000041359,TCL1,T cell lymphoma breakpoint 1,nucleus|cytoplasm|endoplasmic reticulum|cell cortex|intracellular membrane-bounded organelle|pronucleus|,stem cell maintenance|,None,10,-2.1,0.429,10,-0.2,0.0193,-0.5,0.259,0.715,-5,3.4
ENSMUSG00000020474,POLM,"polymerase (DNA directed), mu",nucleus|,DNA-dependent DNA replication|DNA repair|DNA recombination|somatic hypermutation of immunoglobulin genes|B cell differentiation|,DNA binding|DNA-directed DNA polymerase activity|metal ion binding|,10,-0.8,0.664,10,0.3,0.0804,-0.5,0.257,0.716,-4.1,2.9
ENSMUSG00000031207,MSN,moesin,uropod|extracellular space|cytoplasm|cytoskeleton|plasma membrane|microvillus|focal adhesion|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|filopodium|microvillus membrane|apical part of cell|extracellular vesicular exosome|blood microparticle|,cellular component movement|leukocyte cell-cell adhesion|positive regulation of gene expression|membrane to membrane docking|leukocyte migration|establishment of endothelial barrier|regulation of lymphocyte migration|,double-stranded RNA binding|actin binding|receptor binding|structural constituent of cytoskeleton|protein binding|protein kinase binding|cell adhesion molecule binding|,10,-5.3,0.42,10,-0.8,0.567,-0.5,0.257,0.716,-9.6,3
ENSMUSG00000036306,LZTS1,"leucine zipper, putative tumor suppressor 1",nucleoplasm|cytosol|postsynaptic density|apical plasma membrane|cell junction|dendritic spine|dendritic shaft|cell body|postsynaptic membrane|,"transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase III promoter|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription|cell cycle|gene expression|negative regulation of macroautophagy|positive regulation of type I interferon production|innate immune response|regulation of dendrite morphogenesis|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,-0.8,0.945,10,0.4,0.0852,-0.5,0.257,0.716,-5.4,4.6
ENSMUSG00000007877,TCAP,titin-cap,cytosol|Z disc|I band|,somitogenesis|skeletal muscle contraction|cardiac muscle hypertrophy|protein complex assembly|adult heart development|cardiac muscle hypertrophy in response to stress|muscle filament sliding|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|otic vesicle formation|response to muscle stretch|detection of muscle stretch|sarcomere organization|sarcomere organization|cardiac muscle fiber development|sarcomerogenesis|detection of mechanical stimulus|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|,"protein binding|structural constituent of muscle|protein binding, bridging|titin binding|ion channel binding|FATZ binding|titin Z domain binding|",10,-3.3,2.19,10,2.3,0.226,0.5,0.256,0.716,-6.6,4.4
ENSMUSG00000029151,SLC30A3,"solute carrier family 30 (zinc transporter), member 3",cytoplasm|endosome|late endosome|integral component of plasma membrane|synaptic vesicle|membrane|cell junction|synaptic vesicle membrane|neuron projection|,transport|positive regulation of transport|transmembrane transport|regulation of sequestering of zinc ion|zinc ion transmembrane transport|,zinc transporting ATPase activity|,0,0,0,1,0.9,0.278,0.9,0.255,0.717,-1.8,2
ENSMUSG00000034111,TMED8,transmembrane emp24 protein transport domain containing 8,integral component of membrane|,transport|,None,10,-0.6,0.516,10,-0.1,0.0188,-0.3,0.255,0.717,-6.9,1.9
ENSMUSG00000048424,RANBP3L,RAN binding protein 3-like,None,intracellular transport|,None,0,0,0,1,0.9,0.278,0.9,0.255,0.717,-1.8,2
ENSMUSG00000045625,PIGZ,"phosphatidylinositol glycan anchor biosynthesis, class Z",endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,GPI anchor biosynthetic process|GPI anchor biosynthetic process|GPI anchor biosynthetic process|mannosylation|mannosylation|,"alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|",0,0,0,1,0.9,0.278,0.9,0.255,0.717,-1.8,2
ENSMUSG00000030494,RHPN2,"rhophilin, Rho GTPase binding protein 2",nucleus|cytoplasm|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,signal transduction|,None,10,-4.4,1.8,10,0,0,-4.2,0.254,0.717,-8.4,1.4
ENSMUSG00000026414,TNNT2,troponin T type 2 (cardiac),cytosol|troponin complex|striated muscle thin filament|sarcomere|,ATP catabolic process|regulation of muscle contraction|regulation of heart contraction|muscle filament sliding|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|sarcomere organization|response to calcium ion|response to calcium ion|atrial cardiac muscle tissue morphogenesis|ventricular cardiac muscle tissue morphogenesis|,actin binding|structural constituent of cytoskeleton|tropomyosin binding|ATPase activity|troponin C binding|troponin I binding|,10,-3.5,0.739,10,0.9,0.363,0.7,0.254,0.717,-6.3,4
ENSMUSG00000029161,CGREF1,cell growth regulator with EF-hand domain 1,extracellular region|,response to stress|cell cycle arrest|cell adhesion|negative regulation of cell proliferation|negative regulation of cell growth|,calcium ion binding|,10,0.5,0.12,10,-0.8,0.208,-0.6,0.252,0.718,-4.8,3.7
ENSMUSG00000052293,TAF9,"TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa",PCAF complex|nucleoplasm|transcription factor TFIID complex|STAGA complex|transcription factor TFTC complex|pre-snoRNP complex|MLL1 complex|,chromatin organization|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|cellular response to DNA damage stimulus|gene expression|viral process|positive regulation of cell growth|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription from RNA polymerase II promoter|protein stabilization|positive regulation of response to cytokine stimulus|response to interleukin-1|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|,p53 binding|DNA binding|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|activating transcription factor binding|transcription regulatory region DNA binding|protein heterodimerization activity|C2H2 zinc finger domain binding|,10,-3.2,0.759,10,-0.2,0.0672,-0.5,0.252,0.718,-5.6,2.4
ENSMUSG00000042453,RELN,reelin,proteinaceous extracellular matrix|extracellular space|cytoplasm|dendrite|,"cell morphogenesis involved in differentiation|neuron migration|proteolysis|cell adhesion|axon guidance|central nervous system development|brain development|long-term memory|associative learning|glial cell differentiation|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|dendrite development|peptidyl-tyrosine phosphorylation|spinal cord patterning|ventral spinal cord development|hippocampus development|cerebral cortex tangential migration|positive regulation of TOR signaling|positive regulation of CREB transcription factor activity|reelin-mediated signaling pathway|positive regulation of protein kinase activity|response to pain|positive regulation of peptidyl-tyrosine phosphorylation|regulation of behavior|regulation of synaptic transmission|positive regulation of small GTPase mediated signal transduction|positive regulation of synaptic transmission, glutamatergic|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|positive regulation of synapse maturation|N-methyl-D-aspartate receptor clustering|postsynaptic density protein 95 clustering|receptor localization to synapse|lateral motor column neuron migration|positive regulation of long-term synaptic potentiation|positive regulation of lateral motor column neuron migration|regulation of N-methyl-D-aspartate selective glutamate receptor activity|positive regulation of excitatory postsynaptic membrane potential|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|",protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity|metal ion binding|lipoprotein particle receptor binding|very-low-density lipoprotein particle receptor binding|,10,0,0,10,-0.8,0.353,-0.6,0.251,0.718,-4.9,3.6
ENSMUSG00000025964,ADAM23,ADAM metallopeptidase domain 23,extracellular region|integral component of plasma membrane|,proteolysis|cell adhesion|central nervous system development|,metalloendopeptidase activity|integrin binding|protein binding|metallopeptidase activity|zinc ion binding|,10,2,0.803,10,-0.4,0.144,1.4,0.25,0.719,-7.3,6.3
ENSMUSG00000070379,OLFR402,olfactory receptor 402,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,0,0,0,1,-1.4,0.273,-1.4,0.25,0.719,-3,1.7
ENSMUSG00000000693,LOXL3,lysyl oxidase-like 3,extracellular region|extracellular space|nucleus|cytoplasm|membrane|,"epithelial to mesenchymal transition|receptor-mediated endocytosis|negative regulation of transcription, DNA-templated|oxidation-reduction process|",protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|,0,0,0,1,-1.4,0.273,-1.4,0.25,0.719,-3,1.7
ENSMUSG00000036504,PHPT1,phosphohistidine phosphatase 1,cytosol|extracellular vesicular exosome|,protein dephosphorylation|positive regulation of insulin secretion involved in cellular response to glucose stimulus|peptidyl-histidine dephosphorylation|negative regulation of T cell receptor signaling pathway|negative regulation of lyase activity|positive regulation of cell motility|regulation of actin cytoskeleton reorganization|negative regulation of ATP citrate synthase activity|,phosphoprotein phosphatase activity|phosphohistidine phosphatase activity|phosphohistidine phosphatase activity|calcium channel inhibitor activity|ion channel binding|,0,0,0,1,-1.4,0.273,-1.4,0.25,0.719,-3,1.7
ENSMUSG00000035642,AAMDC,"adipogenesis associated, Mth938 domain containing",cytoplasm|cytoplasm|,negative regulation of apoptotic process|positive regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|,None,0,0,0,1,-1.4,0.273,-1.4,0.25,0.719,-3,1.7
ENSMUSG00000004895,PRCC,papillary renal cell carcinoma (translocation-associated),nucleus|intracellular membrane-bounded organelle|,mitotic cell cycle checkpoint|,protein binding|,10,-0.4,0.15,10,0.5,0.21,0.5,0.249,0.719,-4.2,5.8
ENSMUSG00000015522,ARNT,aryl hydrocarbon receptor nuclear translocator,nucleus|nucleoplasm|transcription factor complex|cytoplasm|,"response to hypoxia|embryonic placenta development|positive regulation of endothelial cell proliferation|transcription, DNA-templated|positive regulation vascular endothelial growth factor production|cell differentiation|intracellular receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein sumoylation|mRNA transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of erythrocyte differentiation|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hormone biosynthetic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|",sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription coactivator activity|aryl hydrocarbon receptor activity|protein binding|transcription factor binding|aryl hydrocarbon receptor binding|enhancer binding|sequence-specific DNA binding|protein heterodimerization activity|,10,-0.5,0.385,10,0.8,0.649,-0.3,0.249,0.719,-10.6,3
ENSMUSG00000028973,ABCB8,"ATP-binding cassette, sub-family B (MDR/TAP), member 8",nucleus|nucleolus|mitochondrion|mitochondrial envelope|mitochondrial inner membrane|membrane|integral component of membrane|ATP-binding cassette (ABC) transporter complex|,ATP catabolic process|transport|transmembrane transport|,"transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of substances|",10,0,0,10,-0.5,0.485,-0.5,0.247,0.72,-8.5,3
ENSMUSG00000010067,RASSF1,Ras association (RalGDS/AF-6) domain family member 1,spindle pole|nucleus|cytoplasm|microtubule organizing center|microtubule|plasma membrane|microtubule cytoskeleton|,cellular response to DNA damage stimulus|cell cycle arrest|Ras protein signal transduction|positive regulation of protein ubiquitination|protein stabilization|negative regulation of cell cycle arrest|,protein binding|zinc ion binding|identical protein binding|protein N-terminus binding|,10,2,1.65,10,0,0,0.7,0.245,0.721,-3.7,4.9
ENSMUSG00000005547,CYP2A5,"cytochrome P450, family 2, subfamily a, polypeptide 5",cytoplasmic microtubule|,heme metabolic process|oxidation-reduction process|cellular response to cadmium ion|,coumarin 7-hydroxylase activity|enzyme binding|heme binding|,10,-0.8,1.06,10,0.3,0.187,-0.5,0.245,0.721,-4.6,2
ENSMUSG00000029661,COL1A2,"collagen, type I, alpha 2",extracellular region|collagen type I trimer|collagen type I trimer|collagen type I trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix|extracellular vesicular exosome|,skeletal system development|blood vessel development|transforming growth factor beta receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of blood pressure|extracellular matrix disassembly|platelet activation|extracellular matrix organization|collagen fibril organization|collagen catabolic process|odontogenesis|skin morphogenesis|leukocyte migration|protein heterotrimerization|cellular response to amino acid stimulus|,"extracellular matrix structural constituent|protein binding|protein binding, bridging|identical protein binding|SMAD binding|metal ion binding|platelet-derived growth factor binding|",9,0.7,0.491,10,-0.7,0.709,-0.4,0.244,0.722,-3.6,2.7
ENSMUSG00000035757,SELO,selenoprotein O,None,None,None,10,-4.1,1.29,10,-0.5,0.332,-0.4,0.242,0.723,-7.9,2.2
ENSMUSG00000070469,ADAMTSL3,ADAMTS-like 3,proteinaceous extracellular matrix|,proteolysis|,metallopeptidase activity|zinc ion binding|,10,-0.7,0.9,10,0.3,0.087,-0.4,0.24,0.723,-9,4
ENSMUSG00000036570,FXYD1,FXYD domain containing ion transport regulator 1,plasma membrane|integral component of plasma membrane|chloride channel complex|,chloride transport|cellular calcium ion homeostasis|muscle contraction|ion transmembrane transport|transmembrane transport|chloride transmembrane transport|chloride transmembrane transport|,chloride channel activity|,10,-0.8,0.726,10,0.3,0.125,-0.6,0.239,0.724,-3.6,3.3
ENSMUSG00000052372,IL1RAPL1,interleukin 1 receptor accessory protein-like 1,cytoplasm|plasma membrane|cell surface|integral component of membrane|axon|dendrite|postsynaptic membrane|,heterophilic cell-cell adhesion|signal transduction|regulation of neuron projection development|neuron differentiation|negative regulation of exocytosis|positive regulation of dendrite morphogenesis|calcium ion transmembrane transport|presynaptic membrane assembly|,receptor binding|voltage-gated calcium channel activity|protein binding|,10,0,0,10,0.5,0.603,0.3,0.239,0.724,-8.1,5
ENSMUSG00000062410,HSD3B3,"hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3",mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|membrane|integral component of membrane|,steroid biosynthetic process|metabolic process|oxidation-reduction process|,"catalytic activity|3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid delta-isomerase activity|oxidoreductase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|isomerase activity|",10,-0.1,0.00621,10,2.3,0.859,0.6,0.238,0.724,-3.2,5.4
ENSMUSG00000021484,LMAN2,"lectin, mannose-binding 2",Golgi membrane|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|integral component of plasma membrane|cell surface|endoplasmic reticulum-Golgi intermediate compartment membrane|extracellular vesicular exosome|,"retrograde vesicle-mediated transport, Golgi to ER|protein transport|positive regulation of phagocytosis|",glycoprotein binding|mannose binding|carbohydrate binding|heat shock protein binding|metal ion binding|,0,0,0,1,0.9,0.259,0.9,0.237,0.725,-1.8,2
ENSMUSG00000035818,PLEKHS1,"pleckstrin homology domain containing, family S member 1",None,None,None,10,-0.9,0.429,10,-0.1,0.00945,-0.5,0.235,0.726,-7.1,3.4
ENSMUSG00000004347,PDE1C,"phosphodiesterase 1C, calmodulin-dependent 70kDa",cytosol|,signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|metabolic process|metabolic process|fibroblast growth factor receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|,calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|metal ion binding|,10,0.6,0.28,10,-0.7,0.523,-0.3,0.234,0.726,-5.5,7.9
ENSMUSG00000040174,ALKBH3,"alkB, alkylation repair homolog 3 (E. coli)",nucleoplasm|cytoplasm|,DNA repair|DNA repair|DNA dealkylation involved in DNA repair|DNA dealkylation involved in DNA repair|cell proliferation|oxidative single-stranded DNA demethylation|oxidative single-stranded DNA demethylation|,protein binding|ferrous iron binding|L-ascorbic acid binding|DNA-N1-methyladenine dioxygenase activity|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|,9,-0.5,0.184,9,-0.9,0.0936,-0.5,0.233,0.727,-8.4,3.4
ENSMUSG00000002028,KMT2A,lysine (K)-specific methyltransferase 2A,nucleus|nucleus|cytoplasm|histone methyltransferase complex|MLL1 complex|,"DNA methylation|transcription from RNA polymerase II promoter|protein complex assembly|apoptotic process|negative regulation of cell proliferation|anterior/posterior pattern specification|positive regulation of transporter activity|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|histone H3-K4 methylation|histone H3-K4 methylation|regulation of histone H3-K4 methylation|histone H3-K4 trimethylation|positive regulation of cellular response to drug|",AT DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|histone methyltransferase activity (H3-K4 specific)|histone methyltransferase activity (H3-K4 specific)|identical protein binding|protein homodimerization activity|transcription regulatory region DNA binding|unmethylated CpG binding|lysine-acetylated histone binding|,1,-0.8,0.255,0,0,0,-0.8,0.233,0.727,-2,1.8
ENSMUSG00000063176,OLFR955,olfactory receptor 955,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,1,-0.8,0.255,0,0,0,-0.8,0.233,0.727,-2,1.8
ENSMUSG00000079177,FAM228A,"family with sequence similarity 228, member A",None,None,None,0,0,0,1,-1.4,0.254,-1.4,0.232,0.727,-2,1.8
ENSMUSG00000037992,RARA,"retinoic acid receptor, alpha",nuclear chromatin|nucleus|nucleoplasm|cytoplasm|cell surface|dendrite|neuronal cell body|perinuclear region of cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|liver development|growth plate cartilage development|transcription initiation from RNA polymerase II promoter|protein phosphorylation|signal transduction|germ cell development|spermatogenesis|female pregnancy|positive regulation of cell proliferation|negative regulation of cell proliferation|gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|intracellular estrogen receptor signaling pathway|prostate gland development|negative regulation of granulocyte differentiation|regulation of myelination|response to estradiol|response to retinoic acid|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|response to vitamin A|response to cytokine|multicellular organism growth|regulation of apoptotic process|apoptotic cell clearance|steroid hormone mediated signaling pathway|regulation of phosphatidylinositol 3-kinase activity|response to ethanol|positive regulation of T-helper 2 cell differentiation|positive regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of translational initiation|regulation of synaptic plasticity|retinoic acid receptor signaling pathway|positive regulation of binding|positive regulation of protein kinase B signaling|ventricular cardiac muscle cell differentiation|Sertoli cell fate commitment|chondroblast differentiation|negative regulation of cartilage development|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to estrogen stimulus|","translation repressor activity, nucleic acid binding|retinoic acid binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|retinoic acid receptor activity|transcription coactivator activity|transcription coactivator activity|transcription corepressor activity|receptor binding|protein binding|transcription factor binding|drug binding|zinc ion binding|enzyme binding|protein domain specific binding|chromatin DNA binding|phosphatidylinositol 3-kinase regulator activity|protein kinase B binding|sequence-specific DNA binding|retinoic acid-responsive element binding|protein heterodimerization activity|mRNA 5'-UTR binding|protein kinase A binding|",8,-0.1,0.00566,10,-0.4,0.28,-0.3,0.232,0.727,-3.4,1.5
ENSMUSG00000073650,GM216,N/A,None,None,None,0,0,0,1,-1.4,0.253,-1.4,0.232,0.727,-2,1.8
ENSMUSG00000028434,EPB4.1L4B,erythrocyte protein band 4.1-like 4b,cytoplasm|cytoskeleton|extrinsic component of membrane|apical part of cell|,actomyosin structure organization|,protein binding|cytoskeletal protein binding|,0,0,0,1,-1.4,0.254,-1.4,0.232,0.727,-2,1.8
ENSMUSG00000022875,KNG1,kininogen 1,extracellular region|extracellular region|extracellular space|plasma membrane|platelet alpha granule lumen|extracellular vesicular exosome|blood microparticle|,"platelet degranulation|smooth muscle contraction|inflammatory response|negative regulation of cell adhesion|positive regulation of cytosolic calcium ion concentration|blood coagulation|blood coagulation, intrinsic pathway|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|platelet activation|negative regulation of blood coagulation|positive regulation of urine volume|positive regulation of renal sodium excretion|vasodilation|positive regulation of apoptotic process|negative regulation of proteolysis|",cysteine-type endopeptidase inhibitor activity|receptor binding|protein binding|heparin binding|zinc ion binding|,10,6.2,3.42,10,0,0,6.2,0.232,0.727,-7.2,13
ENSMUSG00000004231,PAX2,paired box 2,nucleus|lysosome|microtubule organizing center|protein-DNA complex|centriolar satellite|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|urogenital system development|branching involved in ureteric bud morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|mesonephros development|neural tube closure|optic cup morphogenesis involved in camera-type eye development|mesenchymal to epithelial transition involved in metanephros morphogenesis|retinal pigment epithelium development|transcription, DNA-templated|transcription from RNA polymerase II promoter|axonogenesis|mesodermal cell fate specification|aging|visual perception|glial cell differentiation|optic nerve development|optic nerve morphogenesis|optic nerve structural organization|vestibulocochlear nerve formation|pancreas development|response to nutrient levels|regulation of metanephros size|ureter maturation|pronephric field specification|inner ear morphogenesis|camera-type eye development|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of programmed cell death|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B signaling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of cytolysis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|pronephros development|brain morphogenesis|stem cell differentiation|positive regulation of epithelial cell proliferation|oxidation-reduction process|oxidation-reduction process|mesenchymal to epithelial transition|paramesonephric duct development|optic chiasma development|cellular response to hydrogen peroxide|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to glucose stimulus|cellular response to epidermal growth factor stimulus|metanephric mesenchyme development|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|metanephric mesenchymal cell differentiation|mesonephric tubule formation|mesonephric duct development|nephric duct formation|ureter development|ureter morphogenesis|metanephric collecting duct development|metanephric epithelium development|metanephric distal convoluted tubule development|metanephric nephron tubule formation|positive regulation of metanephric glomerulus development|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|reactive oxygen species metabolic process|cochlea development|cochlea morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|negative regulation of apoptotic process involved in metanephric collecting duct development|negative regulation of apoptotic process involved in metanephric nephron tubule development|negative regulation of reactive oxygen species metabolic process|positive regulation of metanephric DCT cell differentiation|positive regulation of optic nerve formation|",core promoter proximal region sequence-specific DNA binding|DNA binding|protein binding|superoxide-generating NADPH oxidase activity|transcription regulatory region DNA binding|C2H2 zinc finger domain binding|,10,1.3,0.878,10,0,0,0.4,0.231,0.728,-4.6,4.5
ENSMUSG00000037784,DZIP1L,DAZ interacting zinc finger protein 1-like,centriole|ciliary basal body|,cilium assembly|,metal ion binding|,1,0.8,0.252,0,0,0,0.8,0.23,0.728,-1.8,2
ENSMUSG00000025366,ESYT1,extended synaptotagmin-like protein 1,plasma membrane|membrane|integral component of endoplasmic reticulum membrane|,lipid transport|,protein binding|lipid binding|metal ion binding|,10,0.4,0.268,10,2.3,1.06,1.5,0.23,0.728,-3.6,8.4
ENSMUSG00000051228,NYX,nyctalopin,proteinaceous extracellular matrix|intracellular|,visual perception|biological_process|response to stimulus|,molecular_function|,10,-1,0.493,10,0.4,0.22,0.3,0.23,0.728,-4.4,3.3
ENSMUSG00000036192,RORB,RAR-related orphan receptor B,nucleus|nucleoplasm|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|visual perception|gene expression|intracellular receptor signaling pathway|intracellular receptor signaling pathway|amacrine cell differentiation|eye photoreceptor cell development|regulation of circadian rhythm|steroid hormone mediated signaling pathway|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|retinal rod cell development|retinal cone cell development|rhythmic process|retina development in camera-type eye|cellular response to retinoic acid|",sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|,10,-1.2,1.08,10,1.2,1.92,0.9,0.23,0.728,-3.1,5.7
ENSMUSG00000004366,SST,somatostatin,extracellular region|extracellular space|neuronal cell body|,hyperosmotic response|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|cell-cell signaling|synaptic transmission|response to nutrient|digestion|negative regulation of cell proliferation|hormone-mediated apoptotic signaling pathway|response to heat|regulation of cell migration|response to drug|response to amino acid|response to steroid hormone|,hormone activity|,1,0.8,0.252,0,0,0,0.8,0.23,0.728,-1.8,2
ENSMUSG00000029781,FKBP9,"FK506 binding protein 9, 63 kDa",endoplasmic reticulum|endoplasmic reticulum membrane|,protein peptidyl-prolyl isomerization|protein folding|chaperone-mediated protein folding|,peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|FK506 binding|,10,-2.2,1.85,10,0.4,0.298,-0.4,0.229,0.729,-4.9,5.3
ENSMUSG00000004791,PGF,placental growth factor,extracellular region|extracellular space|membrane|,branching involved in ureteric bud morphogenesis|response to hypoxia|positive regulation of endothelial cell proliferation|sprouting angiogenesis|signal transduction|cell-cell signaling|female pregnancy|positive regulation of cell proliferation|cell differentiation|organ regeneration|cellular response to hormone stimulus|response to drug|positive regulation of angiogenesis|vascular endothelial growth factor receptor signaling pathway|positive regulation of cell division|regulation of morphogenesis of a branching structure|,protein binding|growth factor activity|heparin binding|protein homodimerization activity|protein heterodimerization activity|,10,-0.1,0.00472,10,1.5,0.405,-0.4,0.229,0.729,-3.4,3.6
ENSMUSG00000041852,TCF20,transcription factor 20 (AR1),nucleus|nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|transcription coactivator activity|zinc ion binding|poly(A) RNA binding|,10,0.8,0.576,10,0,0,0.4,0.228,0.729,-5.5,5
ENSMUSG00000003227,EDAR,ectodysplasin A receptor,plasma membrane|integral component of membrane|apical part of cell|,hair follicle development|apoptotic process|signal transduction|epidermis development|cell differentiation|positive regulation of NF-kappaB import into nucleus|odontogenesis of dentin-containing tooth|pigmentation|salivary gland cavitation|,receptor activity|transmembrane signaling receptor activity|protein binding|,10,0.6,0.615,10,0,0,0.3,0.228,0.729,-2.3,4
ENSMUSG00000064293,CNTN4,contactin 4,extracellular region|plasma membrane|axon|anchored component of membrane|,neuron cell-cell adhesion|nervous system development|axonogenesis|axon guidance|axonal fasciculation|brain development|neuron projection development|negative regulation of neuron differentiation|regulation of synaptic plasticity|,None,10,0,0,9,-2.8,0.555,-0.3,0.226,0.73,-8.9,1.6
ENSMUSG00000029636,WASF3,"WAS protein family, member 3",cytoplasm|cytoskeleton|lamellipodium|,protein complex assembly|cytoskeleton organization|regulation of cell shape|oligodendrocyte development|lamellipodium assembly|actin filament polymerization|positive regulation of myelination|,actin binding|,10,1.2,0.77,10,0,0,0.7,0.224,0.731,-2.4,3.9
ENSMUSG00000028453,FANCG,"Fanconi anemia, complementation group G",nucleoplasm|nucleolus|cytoplasm|mitochondrion|plasma membrane|Fanconi anaemia nuclear complex|,cell cycle checkpoint|ovarian follicle development|DNA repair|mitochondrion organization|spermatid development|response to radiation|,damaged DNA binding|protein binding|,8,0.5,0.215,9,-3.7,1.86,-0.5,0.222,0.732,-9.3,3
ENSMUSG00000070348,CCND1,cyclin D1,cyclin-dependent protein kinase holoenzyme complex|intracellular|nucleus|nucleoplasm|cytosol|tight junction|membrane|transcriptional repressor complex|,"G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|re-entry into mitotic cell cycle|liver development|positive regulation of protein phosphorylation|transcription, DNA-templated|protein phosphorylation|cellular response to DNA damage stimulus|Notch signaling pathway|lactation|response to iron ion|response to X-ray|response to organonitrogen compound|positive regulation of G2/M transition of mitotic cell cycle|negative regulation of Wnt signaling pathway|negative regulation of epithelial cell differentiation|endoplasmic reticulum unfolded protein response|organ regeneration|mitotic G1 DNA damage checkpoint|response to magnesium ion|response to vitamin E|Leydig cell differentiation|mammary gland epithelial cell proliferation|positive regulation of mammary gland epithelial cell proliferation|response to drug|response to estrogen|fat cell differentiation|response to ethanol|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|response to corticosterone|response to calcium ion|canonical Wnt signaling pathway|mammary gland alveolus development|response to UV-A|negative regulation of cell cycle arrest|",transcription corepressor activity|protein kinase activity|protein binding|transcription factor binding|cyclin-dependent protein serine/threonine kinase regulator activity|enzyme binding|protein kinase binding|protein complex binding|histone deacetylase binding|proline-rich region binding|,9,0.3,0.108,10,0.5,0.136,0.4,0.22,0.733,-2,4.3
ENSMUSG00000040855,REPS2,RALBP1 associated Eps domain containing 2,cytoplasm|,protein complex assembly|epidermal growth factor receptor signaling pathway|,calcium ion binding|protein binding|,10,1,0.407,10,0,0,0.9,0.22,0.733,-3.5,4.2
ENSMUSG00000021065,FUT8,"fucosyltransferase 8 (alpha (1,6) fucosyltransferase)",Golgi membrane|cytoplasm|Golgi apparatus|membrane|integral component of membrane|Golgi cisterna membrane|extracellular vesicular exosome|,in utero embryonic development|protein N-linked glycosylation|N-glycan processing|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|respiratory gaseous exchange|oligosaccharide biosynthetic process|cell migration|protein N-linked glycosylation via asparagine|protein N-linked glycosylation via asparagine|protein glycosylation in Golgi|N-glycan fucosylation|N-glycan fucosylation|N-glycan fucosylation|L-fucose catabolic process|receptor metabolic process|post-translational protein modification|cellular protein metabolic process|GDP-L-fucose metabolic process|,glycoprotein 6-alpha-L-fucosyltransferase activity|glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding|,10,-0.9,0.729,10,0.3,0.141,-0.6,0.219,0.733,-4.8,8
ENSMUSG00000019763,RMND1,required for meiotic nuclear division 1 homolog (S. cerevisiae),mitochondrion|,translation|,None,0,0,0,1,0.8,0.238,0.8,0.218,0.734,-1.8,2
ENSMUSG00000034690,NLRP4C,"NLR family, pyrin domain containing 4C",extracellular vesicular exosome|,inflammatory response|biological_process|,nucleotide binding|molecular_function|ATP binding|,10,-1.9,0.638,10,-0.3,0.0465,-0.5,0.217,0.734,-4.8,9.1
ENSMUSG00000079259,TRIM71,"tripartite motif containing 71, E3 ubiquitin protein ligase",cytoplasmic mRNA processing body|,G1/S transition of mitotic cell cycle|neural tube closure|fibroblast growth factor receptor signaling pathway|miRNA metabolic process|neural tube development|negative regulation of translation involved in gene silencing by miRNA|protein autoubiquitination|regulation of gene silencing by miRNA|stem cell proliferation|regulation of neural precursor cell proliferation|positive regulation of gene silencing by miRNA|,ubiquitin-protein transferase activity|zinc ion binding|ligase activity|miRNA binding|,0,0,0,1,-1.3,0.236,-1.3,0.216,0.735,-2,1.8
ENSMUSG00000025545,CLYBL,citrate lyase beta like,mitochondrion|,cellular aromatic compound metabolic process|,carbon-carbon lyase activity|metal ion binding|,10,-3.5,1.82,10,0.1,0.0136,0.5,0.216,0.735,-8.8,3.1
ENSMUSG00000047030,SPATA2,spermatogenesis associated 2,nucleus|nucleolus|cytoplasm|,multicellular organismal development|spermatogenesis|cell differentiation|,molecular_function|,9,-5.5,2.34,10,-0.3,0.0884,-0.4,0.215,0.735,-10.6,3.9
ENSMUSG00000026723,TRDMT1,tRNA aspartic acid methyltransferase 1,nucleus|cytoplasm|,response to amphetamine|tRNA methylation|C-5 methylation of cytosine|,DNA binding|RNA binding|DNA (cytosine-5-)-methyltransferase activity|tRNA methyltransferase activity|,0,0,0,1,-1.3,0.235,-1.3,0.215,0.735,-2,1.8
ENSMUSG00000020717,PECAM1,platelet/endothelial cell adhesion molecule 1,extracellular space|plasma membrane|plasma membrane|integral component of membrane|cell junction|platelet alpha granule membrane|extracellular vesicular exosome|,platelet degranulation|phagocytosis|cell adhesion|signal transduction|blood coagulation|cell recognition|platelet activation|extracellular matrix organization|leukocyte migration|diapedesis|glomerular endothelium development|,protein binding|,0,0,0,1,-1.3,0.235,-1.3,0.215,0.735,-2,1.8
ENSMUSG00000021091,SERPINA3N,"serine (or cysteine) peptidase inhibitor, clade A, member 3N",extracellular region|extracellular space|extracellular vesicular exosome|blood microparticle|,acute-phase response|negative regulation of peptidase activity|negative regulation of endopeptidase activity|regulation of proteolysis|response to cytokine|response to peptide hormone|,serine-type endopeptidase inhibitor activity|peptidase inhibitor activity|,0,0,0,1,-1.3,0.235,-1.3,0.215,0.735,-2,1.8
ENSMUSG00000054723,VMAC,vimentin-type intermediate filament associated coiled-coil protein,cytoplasm|,None,None,0,0,0,1,-1.3,0.235,-1.3,0.215,0.735,-2,1.8
ENSMUSG00000071230,NPW,neuropeptide W,extracellular region|,G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior|,G-protein coupled receptor binding|protein binding|,0,0,0,1,-1.3,0.235,-1.3,0.215,0.735,-2,1.8
ENSMUSG00000019966,KITL,kit ligand,extracellular region|extracellular space|cytoplasm|cytoskeleton|plasma membrane|membrane|integral component of membrane|,ovarian follicle development|neural crest cell migration|positive regulation of myeloid leukocyte differentiation|cell adhesion|germ cell development|positive regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell proliferation|negative regulation of mast cell apoptotic process|embryonic hemopoiesis|ectopic germ cell programmed cell death|negative regulation of apoptotic process|positive regulation of MAP kinase activity|positive regulation of melanocyte differentiation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of mast cell proliferation|extrinsic apoptotic signaling pathway in absence of ligand|,cytokine activity|stem cell factor receptor binding|protein binding|growth factor activity|,10,0,0,10,-0.4,0.323,-0.3,0.215,0.735,-3.9,2.4
ENSMUSG00000074771,ANKEF1,ankyrin repeat and EF-hand domain containing 1,None,None,calcium ion binding|,1,0.8,0.233,1,-1.9,0.563,-1.8,0.214,0.736,-3.9,1.8
ENSMUSG00000041624,GUCY1A2,"guanylate cyclase 1, soluble, alpha 2",cytoplasm|,cGMP biosynthetic process|signal transduction|blood coagulation|positive regulation of cGMP biosynthetic process|intracellular signal transduction|,guanylate cyclase activity|GTP binding|heme binding|,10,0,0,10,-2.7,0.394,-0.3,0.214,0.736,-7.9,2.7
ENSMUSG00000073617,HDAC4,histone deacetylase 4,histone deacetylase complex|nucleus|cytoplasm|cytosol|transcriptional repressor complex|Z disc|neuromuscular junction|A band|actomyosin|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|osteoblast development|chromatin remodeling|transcription, DNA-templated|inflammatory response|nervous system development|positive regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of myotube differentiation|regulation of cardiac muscle contraction by calcium ion signaling|response to denervation involved in regulation of muscle adaptation|cardiac muscle hypertrophy in response to stress|histone deacetylation|histone deacetylation|B cell differentiation|positive regulation of protein sumoylation|peptidyl-lysine deacetylation|B cell activation|response to drug|regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of osteoblast differentiation|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of skeletal muscle fiber development|positive regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-1|histone H3 deacetylation|histone H4 deacetylation|",core promoter binding|transcription corepressor activity|histone deacetylase activity|protein binding|transcription factor binding|zinc ion binding|protein kinase binding|potassium ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|activating transcription factor binding|histone deacetylase binding|sequence-specific DNA binding|transcription regulatory region DNA binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|repressing transcription factor binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,0.1,0.00979,10,-1.1,0.558,-1.1,0.214,0.736,-5.8,5.8
ENSMUSG00000029651,MTUS2,microtubule associated tumor suppressor candidate 2,centrosome|cytoplasmic microtubule|,None,protein binding|microtubule binding|protein homodimerization activity|,9,0.8,0.683,10,0,0,0.5,0.213,0.737,-1.8,3.1
ENSMUSG00000026976,PAX8,paired box 8,nucleus|nucleoplasm|,"urogenital system development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|mesenchymal to epithelial transition involved in metanephros morphogenesis|transcription, DNA-templated|central nervous system development|anatomical structure morphogenesis|thyroid gland development|thyroid gland development|thyroid-stimulating hormone signaling pathway|pronephric field specification|inner ear morphogenesis|regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|pronephros development|cellular response to gonadotropin stimulus|otic vesicle development|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephric tubule development|metanephric epithelium development|metanephric distal convoluted tubule development|metanephric comma-shaped body morphogenesis|metanephric S-shaped body morphogenesis|metanephric nephron tubule formation|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|negative regulation of apoptotic process involved in metanephric collecting duct development|negative regulation of apoptotic process involved in metanephric nephron tubule development|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|regulation of thyroid-stimulating hormone secretion|",RNA polymerase II core promoter sequence-specific DNA binding|DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity|protein binding|transcription regulatory region DNA binding|,10,0,0,10,0.7,0.549,0.3,0.213,0.737,-3.1,4.6
ENSMUSG00000000555,ITGA5,"integrin, alpha 5 (fibronectin receptor, alpha polypeptide)",ruffle|cytoplasm|plasma membrane|cell-cell junction|focal adhesion|integrin complex|external side of plasma membrane|ruffle membrane|synapse|alphav-beta3 integrin-vitronectin complex|,"angiogenesis|cell-substrate junction assembly|cell adhesion|heterophilic cell-cell adhesion|leukocyte cell-cell adhesion|integrin-mediated signaling pathway|axon guidance|blood coagulation|memory|positive regulation of cell-substrate adhesion|viral process|extracellular matrix organization|positive regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|cell-substrate adhesion|cell-cell adhesion mediated by integrin|wound healing, spreading of epidermal cells|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|negative regulation of anoikis|",epidermal growth factor receptor binding|platelet-derived growth factor receptor binding|integrin binding|protein binding|vascular endothelial growth factor receptor 2 binding|metal ion binding|,10,0,0,10,1,0.72,0.6,0.211,0.738,-1.7,3.9
ENSMUSG00000033762,RECQL4,RecQ protein-like 4,nucleus|cytoplasm|membrane|,DNA strand renaturation|ATP catabolic process|DNA replication|DNA repair|DNA recombination|multicellular organismal development|DNA duplex unwinding|,bubble DNA binding|ATP binding|zinc ion binding|annealing helicase activity|ATP-dependent 3'-5' DNA helicase activity|,10,-1.9,0.803,10,0,0,-0.4,0.211,0.738,-4.6,1.7
ENSMUSG00000046179,E2F8,E2F transcription factor 8,nucleus|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|placenta development|sprouting angiogenesis|transcription, DNA-templated|cell proliferation|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|cell cycle comprising mitosis without cytokinesis|positive regulation of transcription from RNA polymerase II promoter|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|core promoter binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|protein homodimerization activity|,10,-0.6,0.133,10,0.9,0.868,0.5,0.21,0.738,-5.4,3.3
ENSMUSG00000024056,NDC80,NDC80 kinetochore complex component,"chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome outer kinetochore|nucleus|cytosol|membrane|Ndc80 complex|",mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|cell cycle|spindle organization|mitotic spindle organization|chromosome segregation|mitotic nuclear division|attachment of spindle microtubules to kinetochore|phosphatidylinositol-mediated signaling|,protein binding|,7,-0.7,0.541,7,0,0,-0.4,0.21,0.738,-5.5,2
ENSMUSG00000039005,TLR4,toll-like receptor 4,cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|endosome membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm|,activation of MAPK activity|toll-like receptor signaling pathway|B cell proliferation involved in immune response|nitric oxide production involved in inflammatory response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|positive regulation of platelet activation|detection of fungus|positive regulation of B cell proliferation|lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|response to lipopolysaccharide|detection of lipopolysaccharide|interferon-gamma production|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|T-helper 1 type immune response|macrophage activation|positive regulation of NF-kappaB import into nucleus|positive regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of interleukin-12 biosynthetic process|innate immune response|positive regulation of MHC class II biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of nitric oxide biosynthetic process|negative regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|regulation of cytokine secretion|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|intestinal epithelial structure maintenance|positive regulation of macrophage cytokine production|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to mechanical stimulus|,lipopolysaccharide binding|lipopolysaccharide binding|lipopolysaccharide receptor activity|receptor activity|transmembrane signaling receptor activity|protein binding|,10,0.6,0.234,10,-0.3,0.0651,0.4,0.21,0.738,-9.1,3.2
ENSMUSG00000052056,ZFP217,zinc finger protein 217,histone deacetylase complex|nucleoplasm|,"regulation of transcription, DNA-templated|cell aging|negative regulation of transcription, DNA-templated|",transcription regulatory region DNA binding|,10,-1.6,0.526,10,-0.2,0.0327,-0.5,0.209,0.739,-7.9,4.4
ENSMUSG00000027568,NTSR1,neurotensin receptor 1 (high affinity),endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|,G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|neuropeptide signaling pathway|synaptic transmission|adult locomotory behavior|,G-protein coupled receptor activity|protein binding|G-protein coupled neurotensin receptor activity|,10,-1,0.112,10,-0.5,0.142,-0.6,0.208,0.739,-4.6,3.8
ENSMUSG00000027878,NOTCH2,notch 2,Golgi membrane|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell surface|membrane|receptor complex|,"in utero embryonic development|cell fate determination|morphogenesis of an epithelial sheet|inflammatory response to antigenic stimulus|pulmonary valve morphogenesis|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|apoptotic process|humoral immune response|cell cycle arrest|Notch signaling pathway|Notch receptor processing|multicellular organismal development|determination of left/right symmetry|nervous system development|negative regulation of cell proliferation|organ morphogenesis|gene expression|cell growth|stem cell maintenance|hemopoiesis|embryonic limb morphogenesis|intracellular receptor signaling pathway|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of Ras protein signal transduction|bone remodeling|atrial septum morphogenesis|placenta blood vessel development|Notch signaling involved in heart development|interleukin-4 secretion|",receptor activity|calcium ion binding|protein binding|ligand-activated RNA polymerase II transcription factor binding transcription factor activity|,10,0.5,0.278,10,-5.5,1.66,0.4,0.207,0.74,-10.3,2.4
ENSMUSG00000028945,RHEB,Ras homolog enriched in brain,spliceosomal complex|cytosol|plasma membrane|membrane|dendrite|neuronal cell body|extracellular vesicular exosome|,GTP catabolic process|cell cycle arrest|signal transduction|small GTPase mediated signal transduction|insulin receptor signaling pathway|positive regulation of TOR signaling|,GTPase activity|protein binding|GTP binding|GDP binding|protein kinase binding|metal ion binding|,10,1.7,1.67,9,0,0,0.4,0.207,0.74,-2.7,4.4
ENSMUSG00000020817,RABEP1,"rabaptin, RAB GTPase binding effector protein 1",endosome|early endosome|endocytic vesicle|intracellular membrane-bounded organelle|recycling endosome|,endocytosis|apoptotic process|protein transport|positive regulation of GTPase activity|membrane fusion|,GTPase activator activity|protein binding|growth factor activity|protein homodimerization activity|,10,0,0,10,1.1,1.41,0.5,0.206,0.74,-6.1,6
ENSMUSG00000043909,TRP53BP1,transformation related protein 53 binding protein 1,"chromosome, centromeric region|kinetochore|chromosome, telomeric region|nucleus|nucleus|replication fork|chromosome|cytoplasm|","DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cellular response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity|p53 binding|DNA binding|damaged DNA binding|protein binding|transcription factor binding|methylated histone binding|telomeric DNA binding|,10,0,0,10,1.9,2.1,0.7,0.206,0.74,-2,5.6
ENSMUSG00000039057,MYO16,myosin XVI,nucleoplasm|cytoplasm|cytosol|plasma membrane|myosin complex|perinuclear region of cytoplasm|,metabolic process|negative regulation of cell proliferation|phosphatidylinositol 3-kinase signaling|cerebellum development|neuron projection morphogenesis|negative regulation of G1/S transition of mitotic cell cycle|,motor activity|ATP binding|protein phosphatase binding|actin filament binding|,10,0,0,10,-1.6,0.772,-0.7,0.206,0.74,-5,2.9
ENSMUSG00000038227,HOXA9,homeobox A9,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|endothelial cell activation|negative regulation of myeloid cell differentiation|",sequence-specific DNA binding transcription factor activity|protein binding|enzyme binding|sequence-specific DNA binding|,10,-0.5,0.311,10,0.6,0.218,-0.3,0.205,0.741,-8.4,5.4
ENSMUSG00000025225,NFKB2,nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100),nucleus|nucleoplasm|cytoplasm|cytosol|Bcl3/NF-kappaB2 complex|,"toll-like receptor signaling pathway|follicular dendritic cell differentiation|germinal center formation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|extracellular matrix organization|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|spleen development|positive regulation of NF-kappaB transcription factor activity|",DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|protein binding|,10,-0.8,0.642,10,0,0,-0.4,0.205,0.741,-4.3,2.1
ENSMUSG00000021385,IPPK,"inositol 1,3,4,5,6-pentakisphosphate 2-kinase",intracellular|nucleoplasm|cytosol|,inositol phosphate metabolic process|small molecule metabolic process|inositol phosphorylation|,ATP binding|inositol pentakisphosphate 2-kinase activity|,9,-2.1,0.522,9,-0.4,0.133,-0.4,0.205,0.741,-4.6,4.9
ENSMUSG00000028461,CCDC107,coiled-coil domain containing 107,integral component of membrane|,None,None,0,0,0,2,-0.8,0.223,-0.8,0.204,0.741,-2,1.8
ENSMUSG00000051592,CCNB3,cyclin B3,nucleus|,regulation of cyclin-dependent protein serine/threonine kinase activity|meiotic nuclear division|regulation of G2/M transition of mitotic cell cycle|,protein binding|protein kinase binding|,10,-4.5,0.431,10,-0.5,0.383,-0.4,0.204,0.741,-7.8,1.9
ENSMUSG00000028476,RECK,reversion-inducing-cysteine-rich protein with kazal motifs,plasma membrane|membrane|anchored component of membrane|,blood vessel maturation|embryo implantation|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|extracellular matrix organization|,endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|metalloendopeptidase inhibitor activity|,9,-0.2,0.0227,10,-0.4,0.241,-0.3,0.203,0.742,-8.1,5.1
ENSMUSG00000074971,FIBIN,fin bud initiation factor homolog (zebrafish),extracellular region|endoplasmic reticulum|Golgi apparatus|,None,None,1,0,0,1,1.2,0.442,1.1,0.203,0.742,-1.7,3
ENSMUSG00000013787,EHMT2,euchromatic histone-lysine N-methyltransferase 2,nucleus|nucleoplasm|chromosome|,negative regulation of transcription from RNA polymerase II promoter|regulation of DNA replication|DNA methylation|synaptonemal complex assembly|spermatid development|fertilization|DNA methylation on cytosine within a CG sequence|histone methylation|peptidyl-lysine dimethylation|organ growth|histone H3-K9 methylation|histone H3-K27 methylation|,p53 binding|protein binding|zinc ion binding|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|C2H2 zinc finger domain binding|,10,-2.4,1.18,10,0,0,-0.4,0.202,0.742,-9.2,7.1
ENSMUSG00000016128,STARD13,StAR-related lipid transfer (START) domain containing 13,lipid particle|cytosol|mitochondrial membrane|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|protein binding|lipid binding|,9,1.3,1.55,10,-0.4,0.216,0.7,0.202,0.742,-5.4,4.6
ENSMUSG00000034485,UACA,uveal autoantigen with coiled-coil domains and ankyrin repeats,extracellular region|nucleus|nuclear envelope|cytoplasm|mitochondrion|cytoskeleton|membrane|apoptosome|perinuclear region of cytoplasm|extracellular vesicular exosome|,biological_process|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to UV|positive regulation of protein import into nucleus|negative regulation of NF-kappaB import into nucleus|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of inflammatory response|,molecular_function|protein binding|,10,-3.3,0.624,10,0.6,0.516,-1,0.201,0.742,-5.9,6.6
ENSMUSG00000001482,DEF8,differentially expressed in FDCP 8 homolog (mouse),None,intracellular signal transduction|,zinc ion binding|,10,-0.2,0.0579,10,1.2,0.548,-0.3,0.2,0.743,-3.6,5.6
ENSMUSG00000027459,FAM110A,"family with sequence similarity 110, member A",spindle pole|cytoplasm|microtubule organizing center|,None,protein binding|,10,4.3,0.497,10,-0.3,0.223,-0.3,0.2,0.743,-7,8.7
ENSMUSG00000085795,ZFP703,zinc finger protein 703,nucleus|nucleus|cytoplasm|cytoplasm|nuclear matrix|protein complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell migration|positive regulation of mammary gland epithelial cell proliferation|positive regulation of mammary gland epithelial cell proliferation|negative regulation of homotypic cell-cell adhesion|adherens junction assembly|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|regulation of cell cycle|mammary gland epithelial cell differentiation|regulation of canonical Wnt signaling pathway|cellular response to estradiol stimulus|",nucleic acid binding|metal ion binding|repressing transcription factor binding|,1,-1,0.38,1,0,0,-0.7,0.199,0.743,-2,1.8
ENSMUSG00000030792,DKKL1,dickkopf-like 1,extracellular space|,signal transduction|anatomical structure morphogenesis|positive regulation of fat cell differentiation|,signal transducer activity|,0,0,0,1,-1.3,0.218,-1.3,0.199,0.743,-2,1.8
ENSMUSG00000032491,NRADD,neurotrophin receptor associated death domain,nucleus|nuclear envelope lumen|plasma membrane|membrane|integral component of membrane|lamellipodium|neuron projection membrane|cell body membrane|,apoptotic process|signal transduction|positive regulation of cell death|,neurotrophin p75 receptor binding|protein binding|,0,0,0,1,-1.3,0.218,-1.3,0.199,0.743,-2,1.8
ENSMUSG00000056596,TRNP1,TMF1-regulated nuclear protein 1,nucleus|nuclear euchromatin|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|cerebellar cortex morphogenesis|regulation of cell proliferation|regulation of cell cycle|neural precursor cell proliferation|",DNA binding|,0,0,0,1,-1.3,0.218,-1.3,0.199,0.743,-2,1.8
ENSMUSG00000042826,FGF11,fibroblast growth factor 11,extracellular region|,signal transduction|cell-cell signaling|nervous system development|,growth factor activity|,0,0,0,1,-1.3,0.218,-1.3,0.199,0.743,-2,1.8
ENSMUSG00000037603,GM5519,nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene,None,None,None,0,0,0,1,-1.3,0.218,-1.3,0.199,0.743,-2,1.8
ENSMUSG00000025347,METTL7B,methyltransferase like 7B,None,methylation|,methyltransferase activity|,10,-0.8,0.233,10,-0.3,0.0253,-0.6,0.198,0.744,-5.3,6.4
ENSMUSG00000062190,LANCL2,LanC lantibiotic synthetase component C-like 2 (bacterial),nucleus|cytoplasm|cytosol|plasma membrane|cortical actin cytoskeleton|,"metabolic process|positive regulation of abscisic acid-activated signaling pathway|negative regulation of transcription, DNA-templated|",catalytic activity|ATP binding|GTP binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|,10,-4.2,0.641,10,2.8,2.82,1.9,0.196,0.745,-5.9,6.8
ENSMUSG00000044352,SOWAHA,sosondowah ankyrin repeat domain family member A,None,None,None,10,-1.8,1.55,10,0.7,0.595,-1.8,0.195,0.745,-7.1,3.8
ENSMUSG00000023885,THBS2,thrombospondin 2,extracellular region|basement membrane|,cell adhesion|negative regulation of angiogenesis|positive regulation of synapse assembly|,calcium ion binding|protein binding|heparin binding|,10,5.2,1.34,10,0.1,0.00849,0.3,0.195,0.745,-8.5,12
ENSMUSG00000043051,DISC1,disrupted in schizophrenia 1,mitochondrion|centrosome|microtubule|postsynaptic density|cell junction|postsynaptic membrane|,microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|protein localization|regulation of neuron projection development|cerebral cortex radially oriented cell migration|cell proliferation in forebrain|positive regulation of Wnt signaling pathway|TOR signaling|mitochondrial calcium ion homeostasis|canonical Wnt signaling pathway|regulation of synapse maturation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|,protein binding|,10,-0.1,0.0145,10,-0.6,0.303,-0.4,0.193,0.746,-3.8,2.5
ENSMUSG00000030201,LRP6,low density lipoprotein receptor-related protein 6,early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|caveola|cell surface|integral component of membrane|cytoplasmic vesicle|neuronal cell body|receptor complex|synapse|,"gastrulation with mouth forming second|neural tube closure|negative regulation of protein phosphorylation|heart looping|positive regulation of mesenchymal cell proliferation|pericardium morphogenesis|negative regulation of protein kinase activity|positive regulation of cytosolic calcium ion concentration|synaptic transmission|embryonic pattern specification|anterior/posterior pattern specification|neural crest formation|neural crest cell differentiation|Wnt signaling pathway|Wnt signaling pathway|single organismal cell-cell adhesion|cerebellum morphogenesis|thalamus development|cerebral cortex cell migration|forebrain radial glial cell differentiation|Wnt signaling pathway involved in forebrain neuroblast division|formation of radial glial scaffolds|cerebral cortex development|regulation of ossification|embryonic limb morphogenesis|midbrain development|midbrain-hindbrain boundary development|negative regulation of smooth muscle cell apoptotic process|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|external genitalia morphogenesis|post-anal tail morphogenesis|cell migration involved in gastrulation|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|positive regulation of apoptotic process|response to peptide hormone|Wnt signaling pathway involved in dorsal/ventral axis specification|canonical Wnt signaling pathway involved in neural crest cell differentiation|canonical Wnt signaling pathway involved in regulation of cell proliferation|regulation of fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of ossification|positive regulation of bone resorption|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|bone remodeling|embryonic camera-type eye morphogenesis|negative regulation of epithelial cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|response to folic acid|palate development|convergent extension|embryonic retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|canonical Wnt signaling pathway|regulation of cell development|face morphogenesis|bone morphogenesis|branching involved in mammary gland duct morphogenesis|trachea cartilage morphogenesis|mammary placode formation|canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development|canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|cellular response to cholesterol|dopaminergic neuron differentiation|negative regulation of protein serine/threonine kinase activity|primitive streak formation|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|Wnt signaling pathway involved in somitogenesis|axis elongation involved in somitogenesis|positive regulation of canonical Wnt signaling pathway|toxin transport|positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification|negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis|negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis|negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis|negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis|negative regulation of planar cell polarity pathway involved in pericardium morphogenesis|negative regulation of planar cell polarity pathway involved in neural tube closure|",low-density lipoprotein receptor activity|receptor binding|frizzled binding|protein binding|Wnt-protein binding|kinase inhibitor activity|toxin transporter activity|apolipoprotein binding|identical protein binding|protein homodimerization activity|Wnt-activated receptor activity|coreceptor activity involved in Wnt signaling pathway|,10,-1.3,0.932,10,0.3,0.0605,-0.8,0.191,0.747,-7.7,5.5
ENSMUSG00000023092,FHL1,four and a half LIM domains 1,nucleus|cytoplasm|cytosol|plasma membrane|,regulation of membrane depolarization|muscle organ development|organ morphogenesis|negative regulation of G2/M transition of mitotic cell cycle|cell differentiation|negative regulation of cell growth|positive regulation of potassium ion transport|regulation of potassium ion transmembrane transporter activity|negative regulation of G1/S transition of mitotic cell cycle|,molecular_function|protein binding|zinc ion binding|ion channel binding|,10,0,0,10,0.6,0.332,0.3,0.191,0.747,-1.8,4.4
ENSMUSG00000039756,DNTTIP2,"deoxynucleotidyltransferase, terminal, interacting protein 2",nucleus|nucleolus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",poly(A) RNA binding|,1,-1,0.423,1,0,0,-0.8,0.19,0.748,-2,1.8
ENSMUSG00000011831,EVI5,ecotropic viral integration site 5,nucleus|Golgi apparatus|microtubule organizing center|spindle|intracellular membrane-bounded organelle|,cell cycle|multicellular organismal development|cell proliferation|positive regulation of Rab GTPase activity|cell division|,Rab GTPase activator activity|protein binding|,10,-0.3,0.0191,10,0.6,0.433,0.4,0.19,0.748,-5.9,3.5
ENSMUSG00000051768,XRCC1,X-ray repair complementing defective repair in Chinese hamster cells 1,nucleus|nucleoplasm|,single strand break repair|response to hypoxia|DNA repair|base-excision repair|base-excision repair|response to organic substance|hippocampus development|response to drug|,damaged DNA binding|protein binding|,9,-0.4,0.371,9,0.9,0.4,-0.4,0.19,0.748,-3.2,3.3
ENSMUSG00000055430,NAP1L5,nucleosome assembly protein 1-like 5,nucleus|,nucleosome assembly|,None,10,-0.2,0.0472,10,-0.8,0.3,-0.3,0.189,0.748,-3.5,2.1
ENSMUSG00000037138,AFF3,"AF4/FMR2 family, member 3",nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|response to tumor necrosis factor|embryonic hindlimb morphogenesis|",double-stranded DNA binding|,8,0.8,0.184,9,-2.6,1.07,-0.3,0.188,0.749,-7.5,3.8
ENSMUSG00000034345,GTF2H5,"general transcription factor IIH, polypeptide 5",core TFIIH complex|,"nucleotide-excision repair|transcription, DNA-templated|regulation of transcription, DNA-templated|",None,10,1.3,0.765,10,-0.4,0.0695,0.5,0.187,0.75,-3.2,3.7
ENSMUSG00000032253,PHIP,pleckstrin homology domain interacting protein,nucleus|extracellular vesicular exosome|,"regulation of protein phosphorylation|protein import into nucleus|cytoskeleton organization|positive regulation of cell proliferation|insulin receptor signaling pathway|positive regulation of peptidyl-threonine phosphorylation|regulation of cell morphogenesis|positive regulation of peptidyl-serine phosphorylation|regulation of growth|negative regulation of apoptotic process|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of extrinsic apoptotic signaling pathway|",insulin receptor binding|protein binding|lysine-acetylated histone binding|,10,0.8,0.583,10,0,0,0.3,0.186,0.75,-2.5,3.8
ENSMUSG00000071347,C1QTNF9,C1q and tumor necrosis factor related protein 9,extracellular region|collagen trimer|,None,hormone activity|,10,0,0,10,-1.4,1.07,-0.3,0.186,0.75,-7.9,2.8
ENSMUSG00000030102,ITPR1,"inositol 1,4,5-trisphosphate receptor, type 1",nuclear inner membrane|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|calcineurin complex|postsynaptic density|membrane|integral component of membrane|sarcoplasmic reticulum|platelet dense granule membrane|platelet dense tubular network|platelet dense tubular network membrane|,response to hypoxia|energy reserve metabolic process|calcium ion transport|signal transduction|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|blood coagulation|fibroblast growth factor receptor signaling pathway|post-embryonic development|platelet activation|endoplasmic reticulum calcium ion homeostasis|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|inositol phosphate-mediated signaling|inositol phosphate-mediated signaling|inositol phosphate-mediated signaling|regulation of insulin secretion|voluntary musculoskeletal movement|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion transmembrane transport|,"intracellular ligand-gated calcium channel activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|protein binding|calcium ion transmembrane transporter activity|phosphatidylinositol binding|",10,-2.8,0.906,10,-0.2,0.0129,0.9,0.185,0.751,-7.5,6.5
ENSMUSG00000023947,NFKBIE,"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon",cytoplasm|Golgi apparatus|cytosol|perinuclear region of cytoplasm|,D-serine transport|cytoplasmic sequestering of transcription factor|,protein binding|,0,0,0,1,-1.2,0.202,-1.2,0.184,0.751,-2,1.8
ENSMUSG00000037363,LETM2,leucine zipper-EF-hand containing transmembrane protein 2,mitochondrial inner membrane|integral component of membrane|,None,None,0,0,0,1,0.8,0.201,0.8,0.184,0.751,-1.8,2
ENSMUSG00000038240,PDSS2,"prenyl (decaprenyl) diphosphate synthase, subunit 2",cytoplasm|mitochondrial matrix|,ubiquinone biosynthetic process|ubiquinone biosynthetic process|ubiquinone biosynthetic process|isoprenoid biosynthetic process|small molecule metabolic process|regulation of body fluid levels|protein heterotetramerization|,trans-hexaprenyltranstransferase activity|protein heterodimerization activity|trans-octaprenyltranstransferase activity|,0,0,0,1,0.8,0.201,0.8,0.184,0.751,-1.8,2
ENSMUSG00000025060,SLK,STE20-like kinase,cytoplasm|extracellular vesicular exosome|,apoptotic process|signal transduction by phosphorylation|protein autophosphorylation|,protein serine/threonine kinase activity|ATP binding|identical protein binding|protein homodimerization activity|,0,0,0,1,-1.2,0.202,-1.2,0.184,0.751,-2,1.8
ENSMUSG00000024911,FIBP,fibroblast growth factor (acidic) intracellular binding protein,nucleus|mitochondrion|endomembrane system|membrane|extracellular vesicular exosome|,fibroblast growth factor receptor signaling pathway|,fibroblast growth factor binding|,0,0,0,1,0.8,0.201,0.8,0.184,0.751,-1.8,2
ENSMUSG00000026691,FMO3,flavin containing monooxygenase 3,endoplasmic reticulum membrane|integral component of membrane|intracellular membrane-bounded organelle|,xenobiotic metabolic process|drug metabolic process|small molecule metabolic process|oxidation-reduction process|,"N,N-dimethylaniline monooxygenase activity|amino acid binding|trimethylamine monooxygenase activity|flavin adenine dinucleotide binding|NADP binding|",0,0,0,1,-1.2,0.202,-1.2,0.184,0.751,-2,1.8
ENSMUSG00000026342,SLC35F5,"solute carrier family 35, member F5",integral component of membrane|,transport|,None,0,0,0,1,0.8,0.201,0.8,0.184,0.751,-1.8,2
ENSMUSG00000033156,CST10,cystatin 10 (chondrocytes),extracellular region|cytosol|extracellular vesicular exosome|,chondrocyte differentiation|negative regulation of peptidase activity|negative regulation of endopeptidase activity|cell maturation|,cysteine-type endopeptidase inhibitor activity|peptidase inhibitor activity|,10,0.5,0.283,10,-0.4,0.215,-0.4,0.183,0.752,-5.9,3.3
ENSMUSG00000029790,CEP41,centrosomal protein 41kDa,centrosome|centriole|cytosol|membrane|ciliary basal body|primary cilium|,G2/M transition of mitotic cell cycle|mitotic cell cycle|protein transport|protein polyglutamylation|cilium assembly|,protein binding|,10,-0.3,0.162,10,-0.2,0.0665,-0.2,0.182,0.752,-10.1,2.1
ENSMUSG00000024659,ANXA1,annexin A1,cornified envelope|extracellular region|extracellular space|nucleus|cytoplasm|cytoplasm|plasma membrane|cilium|cell surface|basolateral plasma membrane|mitochondrial membrane|sarcolemma|protein complex|extracellular vesicular exosome|,neutrophil homeostasis|negative regulation of acute inflammatory response|cellular component movement|inflammatory response|signal transduction|cell surface receptor signaling pathway|response to X-ray|peptide cross-linking|insulin secretion|keratinocyte differentiation|endocrine pancreas development|positive regulation of vesicle fusion|positive regulation of prostaglandin biosynthetic process|response to estradiol|positive regulation of neutrophil apoptotic process|gliogenesis|regulation of cell proliferation|response to drug|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of catalytic activity|response to peptide hormone|alpha-beta T cell differentiation|arachidonic acid secretion|estrous cycle phase|cellular response to hydrogen peroxide|hepatocyte differentiation|response to interleukin-1|cellular response to glucocorticoid stimulus|neutrophil clearance|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of interleukin-8 secretion|,"receptor binding|structural molecule activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|protein homodimerization activity|calcium-dependent protein binding|",9,-0.8,0.0724,10,1.2,0.918,0.4,0.181,0.752,-2.8,4.4
ENSMUSG00000095795,PARK2,parkin RBR E3 ubiquitin protein ligase,ubiquitin ligase complex|nucleus|cytoplasm|mitochondrion|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|aggresome|perinuclear region of cytoplasm|,"protein polyubiquitination|mitochondrion degradation|negative regulation of protein phosphorylation|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|central nervous system development|cell death|regulation of autophagy|protein ubiquitination|negative regulation of actin filament bundle assembly|negative regulation of glucokinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of neuron apoptotic process|cellular protein catabolic process|negative regulation of insulin secretion|protein autoubiquitination|negative regulation of cell death|protein K63-linked ubiquitination|aggresome assembly|protein K48-linked ubiquitination|neuron death|negative regulation of release of cytochrome c from mitochondria|negative regulation of neuron death|regulation of reactive oxygen species metabolic process|",ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|kinase binding|protein kinase binding|PDZ domain binding|ubiquitin protein ligase binding|identical protein binding|ubiquitin binding|chaperone binding|ubiquitin protein ligase activity|ubiquitin-specific protease binding|,8,0,0,8,-0.6,0.54,-0.4,0.18,0.753,-6.7,3
ENSMUSG00000038871,BPGM,"2,3-bisphosphoglycerate mutase",None,carbohydrate metabolic process|glycolytic process|respiratory gaseous exchange|dephosphorylation|erythrocyte development|,bisphosphoglycerate mutase activity|bisphosphoglycerate 2-phosphatase activity|phosphoglycerate mutase activity|,10,1.4,1.06,10,-1.2,1.23,-0.7,0.18,0.753,-4,4.6
ENSMUSG00000076747,TCRG-V5,"T cell receptor gamma, variable 5",None,None,None,10,0.3,0.139,10,0.4,0.0646,0.3,0.18,0.753,-3.5,4.3
ENSMUSG00000043631,ECM2,"extracellular matrix protein 2, female organ and adipocyte specific",proteinaceous extracellular matrix|interstitial matrix|,cell-matrix adhesion|positive regulation of cell-substrate adhesion|extracellular matrix organization|,integrin binding|heparin binding|collagen V binding|,10,0.9,0.684,9,0,0,0.5,0.18,0.753,-4.1,4
ENSMUSG00000033826,DNAH8,"dynein, axonemal, heavy chain 8",axonemal dynein complex|microtubule|motile cilium|,cilium or flagellum-dependent cell motility|ATP catabolic process|microtubule-based movement|metabolic process|,microtubule motor activity|ATP binding|ATPase activity|,10,-0.9,0.674,10,0,0,-0.5,0.179,0.753,-6.2,3
ENSMUSG00000058258,IDI1,isopentenyl-diphosphate delta isomerase 1,mitochondrion|peroxisome|cytosol|,cholesterol biosynthetic process|isoprenoid biosynthetic process|isoprenoid biosynthetic process|response to stilbenoid|small molecule metabolic process|dimethylallyl diphosphate biosynthetic process|,magnesium ion binding|isopentenyl-diphosphate delta-isomerase activity|isopentenyl-diphosphate delta-isomerase activity|hydrolase activity|manganese ion binding|metal ion binding|,9,-0.3,0.145,8,-0.2,0.0528,-0.3,0.178,0.754,-4.3,3
ENSMUSG00000027221,CHST1,carbohydrate (keratan sulfate Gal-6) sulfotransferase 1,Golgi membrane|integral component of membrane|,carbohydrate metabolic process|polysaccharide metabolic process|galactose metabolic process|sulfur compound metabolic process|inflammatory response|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate metabolic process|small molecule metabolic process|,sulfotransferase activity|keratan sulfotransferase activity|,10,0.3,0.0401,9,-0.6,0.36,-0.5,0.178,0.754,-4,4.5
ENSMUSG00000066113,ADAMTSL1,ADAMTS-like 1,proteinaceous extracellular matrix|,proteolysis|,metallopeptidase activity|zinc ion binding|,9,-0.4,0.286,9,0,0,-0.3,0.178,0.754,-3.5,2.2
ENSMUSG00000037771,SLC32A1,"solute carrier family 32 (GABA vesicular transporter), member 1",plasma membrane|integral component of membrane|dendrite|synaptic vesicle membrane|neuron projection|dendrite terminus|neuron projection terminus|cone cell pedicle|cell tip|inhibitory synapse|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|,ion transport|synaptic transmission|neurotransmitter secretion|aging|gamma-aminobutyric acid transport|glycine transport|transmembrane transport|,glycine transmembrane transporter activity|gamma-aminobutyric acid:proton symporter activity|,9,-1.6,0.0409,10,-0.7,0.224,-0.4,0.177,0.754,-7.1,2.9
ENSMUSG00000021340,GPLD1,glycosylphosphatidylinositol specific phospholipase D1,proteinaceous extracellular matrix|extracellular space|intracellular|cytoplasm|cytoplasm|lysosomal membrane|intracellular membrane-bounded organelle|,ossification|cell migration involved in sprouting angiogenesis|chondrocyte differentiation|complement receptor mediated signaling pathway|GPI anchor release|GPI anchor release|negative regulation of cell proliferation|insulin receptor signaling pathway|response to glucose|positive regulation of endothelial cell migration|positive regulation of alkaline phosphatase activity|positive regulation of triglyceride biosynthetic process|negative regulation of triglyceride catabolic process|positive regulation of glucose metabolic process|positive regulation of high-density lipoprotein particle clearance|cellular response to insulin stimulus|cellular response to drug|hematopoietic stem cell migration|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of apoptotic process|positive regulation of cytolysis|phosphatidylcholine metabolic process|phosphatidylcholine metabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of secretion|transepithelial transport|cellular response to calcium ion|cellular response to cholesterol|cellular response to triglyceride|cellular response to pH|hematopoietic stem cell migration to bone marrow|regulation of cellular response to insulin stimulus|,glycosylphosphatidylinositol phospholipase D activity|glycosylphosphatidylinositol phospholipase D activity|phospholipase D activity|sodium channel regulator activity|,9,0,0,9,-0.7,0.263,-0.5,0.177,0.754,-7.3,3
ENSMUSG00000032508,MYD88,myeloid differentiation primary response 88,cytosol|plasma membrane|endosome membrane|,toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|inflammatory response|signal transduction|cell surface receptor signaling pathway|positive regulation of type I interferon production|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|neurotrophin TRK receptor signaling pathway|regulation of inflammatory response|defense response to Gram-positive bacterium|response to interleukin-1|3'-UTR-mediated mRNA stabilization|cellular response to mechanical stimulus|,death receptor binding|protein binding|identical protein binding|TIR domain binding|,10,-0.2,0.0527,10,0.7,0.416,0.3,0.177,0.754,-3,3.8
ENSMUSG00000022878,ADIPOQ,"adiponectin, C1Q and collagen domain containing",extracellular region|collagen trimer|extracellular space|endoplasmic reticulum|cell surface|extracellular vesicular exosome|,"response to hypoxia|positive regulation of protein phosphorylation|glucose metabolic process|generation of precursor metabolites and energy|fatty acid beta-oxidation|response to nutrient|circadian rhythm|response to sucrose|response to glucose|positive regulation of signal transduction|negative regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase A signaling|negative regulation of macrophage derived foam cell differentiation|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cholesterol efflux|regulation of glucose metabolic process|response to activity|negative regulation of smooth muscle cell migration|fatty acid oxidation|negative regulation of cell migration|negative regulation of granulocyte differentiation|negative regulation of protein autophosphorylation|positive regulation of cellular protein metabolic process|negative regulation of tumor necrosis factor production|positive regulation of interleukin-8 production|cellular response to insulin stimulus|positive regulation of myeloid cell apoptotic process|adiponectin-activated signaling pathway|negative regulation of heterotypic cell-cell adhesion|low-density lipoprotein particle clearance|response to tumor necrosis factor|cellular response to drug|glucose homeostasis|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|response to ethanol|negative regulation of fat cell differentiation|negative regulation of macrophage differentiation|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of gluconeogenesis|negative regulation of blood pressure|positive regulation of blood pressure|negative regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of glucose import|negative regulation of hormone secretion|negative regulation of smooth muscle cell proliferation|negative regulation of inflammatory response|negative regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of phagocytosis|negative regulation of synaptic transmission|brown fat cell differentiation|protein homooligomerization|response to glucocorticoid|membrane depolarization|membrane hyperpolarization|protein heterotrimerization|negative regulation of ERK1 and ERK2 cascade|response to linoleic acid|detection of oxidative stress|cellular response to cAMP|positive regulation of monocyte chemotactic protein-1 production|cellular response to epinephrine stimulus|protein localization to plasma membrane|negative regulation of intracellular protein transport|negative regulation of receptor binding|negative regulation of DNA biosynthetic process|positive regulation of glycogen (starch) synthase activity|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of cAMP-dependent protein kinase activity|positive regulation of renal albumin absorption|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|negative regulation of metanephric mesenchymal cell migration|",receptor binding|cytokine activity|hormone activity|protein binding|sialic acid binding|identical protein binding|protein homodimerization activity|,0,0,0,1,-1.2,0.194,-1.2,0.177,0.754,-2,1.8
ENSMUSG00000055373,FUT9,"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)",Golgi apparatus|integral component of membrane|Golgi cisterna membrane|,carbohydrate metabolic process|protein glycosylation|protein glycosylation|nervous system development|fucosylation|fucosylation|L-fucose catabolic process|,fucosyltransferase activity|alpha-(1->3)-fucosyltransferase activity|,10,0.7,0.105,10,-1,0.335,-0.9,0.175,0.756,-5.1,4.9
ENSMUSG00000021025,NFKBIA,"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha",nucleus|cytoplasm|cytosol|plasma membrane|I-kappaB/NF-kappaB complex|,"protein import into nucleus, translocation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|apoptotic process|cytoplasmic sequestering of NF-kappaB|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of lipid storage|viral process|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|positive regulation of type I interferon production|response to muramyl dipeptide|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|regulation of cell proliferation|regulation of NF-kappaB import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of apoptotic process|response to exogenous dsRNA|negative regulation of DNA binding|innate immune response|negative regulation of myeloid cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|cellular response to cold|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|",protein binding|transcription factor binding|nuclear localization sequence binding|enzyme binding|heat shock protein binding|ubiquitin protein ligase binding|protein complex binding|identical protein binding|NF-kappaB binding|NF-kappaB binding|,10,-0.8,0.462,10,0,0,-0.5,0.175,0.756,-7.1,4.4
ENSMUSG00000009900,WNT3A,"wingless-type MMTV integration site family, member 3A",extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|,"osteoblast differentiation|in utero embryonic development|positive regulation of protein phosphorylation|heart looping|positive regulation of receptor internalization|negative regulation of heart induction by canonical Wnt signaling pathway|axon guidance|positive regulation of cell proliferation|COP9 signalosome assembly|negative regulation of neuron projection development|spinal cord association neuron differentiation|hippocampus development|cell proliferation in forebrain|Wnt signaling pathway involved in forebrain neuroblast division|dorsal/ventral neural tube patterning|hemopoiesis|neuron differentiation|neuron differentiation|extracellular matrix organization|mammary gland development|positive regulation of B cell proliferation|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|cellular protein localization|positive regulation of catenin import into nucleus|skeletal muscle cell differentiation|post-anal tail morphogenesis|inner ear morphogenesis|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of mesodermal cell fate specification|paraxial mesodermal cell fate commitment|positive regulation of collateral sprouting in absence of injury|negative regulation of axon extension involved in axon guidance|negative regulation of neurogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|palate development|canonical Wnt signaling pathway|positive regulation of protein tyrosine kinase activity|positive regulation of dermatome development|canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|regulation of microtubule cytoskeleton organization|platelet aggregation|cellular response to retinoic acid|axis elongation involved in somitogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation|positive regulation of cardiac muscle cell differentiation|",transcription coactivator activity|frizzled binding|frizzled-2 binding|protein binding|protein domain specific binding|receptor agonist activity|,10,1.2,0.764,10,-0.9,0.24,-0.8,0.174,0.756,-4.5,3.9
ENSMUSG00000046160,OLIG1,oligodendrocyte transcription factor 1,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|neuron fate commitment|",DNA binding|protein binding|protein dimerization activity|,10,-2.7,1.98,10,0.9,0.646,-0.7,0.173,0.757,-5.5,3.1
ENSMUSG00000055320,TEAD1,TEA domain family member 1 (SV40 transcriptional enhancer factor),nucleus|nucleoplasm|cytoplasm|Golgi apparatus|,"regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|gene expression|hippo signaling|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,0.3,0.0886,10,1,0.382,0.7,0.173,0.757,-3.6,6.8
ENSMUSG00000005698,CTCF,CCCTC-binding factor (zinc finger protein),"chromosome, centromeric region|condensed chromosome|nucleus|nucleoplasm|nucleolus|","negative regulation of transcription from RNA polymerase II promoter|regulation of gene expression by genetic imprinting|transcription, DNA-templated|chromosome segregation|maintenance of DNA methylation|positive regulation of gene expression|chromatin modification|nucleosome positioning|regulation of histone methylation|regulation of histone acetylation|regulation of gene expression, epigenetic|regulation of molecular function, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of centromeric sister chromatid cohesion|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|zinc ion binding|chromatin insulator sequence binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,9,0.1,0.019,9,-0.9,0.72,-0.7,0.172,0.757,-5.2,2.7
ENSMUSG00000055485,SOGA1,"suppressor of glucose, autophagy associated 1",extracellular space|extracellular vesicular exosome|,insulin receptor signaling pathway|regulation of autophagy|negative regulation of gluconeogenesis|,molecular_function|,0,0,0,1,0.7,0.188,0.7,0.172,0.757,-1.8,2
ENSMUSG00000025793,HGS,hepatocyte growth factor-regulated tyrosine kinase substrate,cytoplasm|endosome|early endosome|cytosol|secretory granule|early endosome membrane|multivesicular body membrane|intracellular membrane-bounded organelle|extracellular vesicular exosome|,intracellular protein transport|signal transduction|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|endosome to lysosome transport|endosomal transport|endosomal transport|negative regulation of epidermal growth factor receptor signaling pathway|regulation of protein catabolic process|negative regulation of JAK-STAT cascade|membrane organization|,protein binding|protein domain specific binding|metal ion binding|,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000094258,GM8159,predicted gene 8159,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000042423,FBRS,fibrosin,None,None,None,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000090827,GM8297,predicted gene 8297,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000006262,MOB1B,MOB kinase activator 1B,nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,hippo signaling|hippo signaling|positive regulation of phosphorylation|protein autophosphorylation|,protein binding|kinase activator activity|kinase binding|metal ion binding|,10,-0.1,0.00111,10,-0.5,0.317,-0.3,0.171,0.758,-3.8,3.1
ENSMUSG00000035762,TMEM161B,transmembrane protein 161B,integral component of membrane|,None,None,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000030055,RAB43,"RAB43, member RAS oncogene family",Golgi apparatus|phagocytic vesicle membrane|phagocytic vesicle|extracellular vesicular exosome|,"GTP catabolic process|Golgi organization|small GTPase mediated signal transduction|protein transport|retrograde transport, plasma membrane to Golgi|phagosome maturation|",GTPase activity|GTP binding|,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000036009,METTL25,methyltransferase like 25,None,methylation|,methyltransferase activity|,0,0,0,1,-1.2,0.187,-1.2,0.171,0.758,-2,1.8
ENSMUSG00000054499,DEDD2,death effector domain containing 2,nucleolus|,"transcription, DNA-templated|RNA processing|extrinsic apoptotic signaling pathway via death domain receptors|rRNA catabolic process|cellular homeostasis|apoptotic nuclear changes|intracellular signal transduction|negative regulation of transcription, DNA-templated|positive regulation of extrinsic apoptotic signaling pathway|",DNA binding|protein binding|receptor signaling complex scaffold activity|,10,0.6,0.268,10,-0.3,0.0513,-0.4,0.17,0.758,-5,3.4
ENSMUSG00000003949,HLF,hepatic leukemia factor,nucleus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|multicellular organismal development|skeletal muscle cell differentiation|rhythmic process|",DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,3.5,2.33,10,-0.4,0.228,-1.1,0.17,0.758,-3.4,7.4
ENSMUSG00000023088,ABCC1,"ATP-binding cassette, sub-family C (CFTR/MRP), member 1",plasma membrane|plasma membrane|integral component of plasma membrane|membrane|extracellular vesicular exosome|,ATP catabolic process|ATP catabolic process|leukotriene metabolic process|vitamin metabolic process|water-soluble vitamin metabolic process|transport|cobalamin metabolic process|arachidonic acid metabolic process|response to drug|small molecule metabolic process|transmembrane transport|,"transporter activity|ATP binding|ATPase activity|ATPase activity, coupled to transmembrane movement of substances|",10,0,0,10,0.5,0.324,0.3,0.169,0.759,-2.4,3.2
ENSMUSG00000031196,F8,"coagulation factor VIII, procoagulant component",extracellular region|extracellular region|extracellular space|plasma membrane|platelet alpha granule lumen|,"platelet degranulation|proteolysis|acute-phase response|cell adhesion|blood coagulation|blood coagulation, intrinsic pathway|platelet activation|oxidation-reduction process|",serine-type endopeptidase activity|copper ion binding|protein binding|oxidoreductase activity|,10,0,0,10,0.6,0.525,0.3,0.169,0.759,-2.4,3.1
ENSMUSG00000031097,TNNI2,"troponin I type 2 (skeletal, fast)",nucleus|cytosol|troponin complex|,"skeletal muscle contraction|muscle filament sliding|positive regulation of transcription, DNA-templated|",actin binding|protein binding|troponin T binding|,10,-0.3,0.136,10,-0.2,0.0497,-0.3,0.168,0.759,-9.1,3.3
ENSMUSG00000060675,PLA2G16,"phospholipase A2, group XVI",cellular_component|endoplasmic reticulum|cytosol|integral component of membrane|perinuclear region of cytoplasm|,phospholipid metabolic process|phospholipid metabolic process|lipid catabolic process|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|small molecule metabolic process|negative regulation of cell cycle|glycerophospholipid biosynthetic process|,phospholipase A2 activity|protein binding|phosphatidylcholine 1-acylhydrolase activity|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|,10,-0.9,0.794,10,0,0,-0.6,0.167,0.76,-7.4,3.5
ENSMUSG00000043753,DMRTA1,DMRT-like family A1,nucleus|,"ovarian follicle development|transcription, DNA-templated|regulation of transcription, DNA-templated|male mating behavior|",sequence-specific DNA binding transcription factor activity|protein homodimerization activity|sequence-specific DNA binding|metal ion binding|,1,-0.7,0.183,0,0,0,-0.7,0.167,0.76,-2,1.8
ENSMUSG00000041846,SMEK1,"SMEK homolog 1, suppressor of mek1 (Dictyostelium)",nucleus|cytoplasm|microtubule organizing center|protein phosphatase 4 complex|,protein dephosphorylation|positive regulation of gluconeogenesis|,None,10,0,0,10,-0.8,0.618,-0.5,0.166,0.76,-3.7,1.8
ENSMUSG00000036918,TTC7,tetratricopeptide repeat domain 7,None,cellular iron ion homeostasis|hemopoiesis|,None,0,0,0,1,-1.2,0.182,-1.2,0.166,0.76,-2,1.8
ENSMUSG00000034881,TBXA2R,thromboxane A2 receptor,acrosomal vesicle|plasma membrane|integral component of plasma membrane|,inflammatory response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|response to nutrient|blood coagulation|second-messenger-mediated signaling|platelet activation|response to lipopolysaccharide|thromboxane A2 signaling pathway|response to drug|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of blood pressure|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|,thromboxane A2 receptor activity|guanyl-nucleotide exchange factor activity|protein binding|,9,-5,0.154,10,0.9,0.801,0.4,0.165,0.761,-9.6,4.2
ENSMUSG00000024032,TFF1,trefoil factor 1,extracellular space|,carbohydrate metabolic process|digestion|negative regulation of cell proliferation|response to iron ion|cell differentiation|maintenance of gastrointestinal epithelium|response to estradiol|response to peptide hormone|,protein binding|growth factor activity|,10,-0.6,0.208,10,-0.2,0.048,-0.3,0.164,0.761,-4.1,2.2
ENSMUSG00000070425,TRPC2,"transient receptor potential cation channel, subfamily C, member 2, pseudogene",None,None,None,10,-0.9,0.436,10,-0.1,0.000681,-0.4,0.163,0.762,-8.1,3.5
ENSMUSG00000032554,TRF,transferrin,extracellular region|basement membrane|extracellular space|endosome|early endosome|early endosome|late endosome|coated pit|coated pit|basal plasma membrane|cell surface|cytoplasmic membrane-bounded vesicle|apical plasma membrane|vesicle coat|endocytic vesicle|endocytic vesicle|basal part of cell|perinuclear region of cytoplasm|recycling endosome|recycling endosome|extracellular vesicular exosome|blood microparticle|dense body|,"transport|ion transport|iron ion transport|cellular iron ion homeostasis|actin filament organization|activation of JUN kinase activity|ferric iron transport|osteoclast differentiation|positive regulation of myelination|iron ion transmembrane transport|positive regulation of phosphorylation|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|iron ion homeostasis|SMAD protein signal transduction|ERK1 and ERK2 cascade|positive regulation of oligodendrocyte progenitor proliferation|positive regulation of cell motility|",protein binding|ferric iron binding|ferric iron transmembrane transporter activity|metal ion binding|,10,-4,0.542,10,0,0,-0.4,0.163,0.762,-7.5,8.3
ENSMUSG00000039745,HTATIP2,"HIV-1 Tat interactive protein 2, 30kDa",nucleus|nuclear envelope|cytoplasm|membrane|,angiogenesis|regulation of transcription from RNA polymerase II promoter|apoptotic process|viral process|cell differentiation|negative regulation of apoptotic process|regulation of angiogenesis|nuclear import|oxidation-reduction process|,transcription coactivator activity|protein binding|oxidoreductase activity|,10,-0.5,0.188,10,-0.2,0.0486,-0.3,0.163,0.762,-7.6,4.4
ENSMUSG00000041966,DCAF17,DDB1 and CUL4 associated factor 17,nucleolus|integral component of membrane|Cul4-RING E3 ubiquitin ligase complex|,protein ubiquitination|protein ubiquitination|,None,0,0,0,2,-1.8,0.177,-1.8,0.162,0.762,-3.7,2
ENSMUSG00000026048,ERCC5,excision repair cross-complementation group 5,"nucleus|nucleoplasm|DNA replication factor A complex|holo TFIIH complex|DNA-directed RNA polymerase II, holoenzyme|intermediate filament cytoskeleton|","nucleotide-excision repair, DNA damage removal|DNA catabolic process, endonucleolytic|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV|response to UV|UV protection|response to UV-C|negative regulation of apoptotic process|",bubble DNA binding|double-stranded DNA binding|single-stranded DNA binding|endonuclease activity|endodeoxyribonuclease activity|protein binding|protein homodimerization activity|metal ion binding|protein N-terminus binding|,10,0.1,0.0133,10,-0.8,0.648,0.4,0.162,0.762,-4.2,5.3
ENSMUSG00000022435,UPK3A,uroplakin 3A,endoplasmic reticulum membrane|integral component of membrane|apical plasma membrane|extracellular vesicular exosome|,cell morphogenesis|kidney development|water transport|urea transport|epithelial cell differentiation|potassium ion homeostasis|sodium ion homeostasis|urinary bladder development|,None,10,-3.3,0.989,10,0,0,-0.7,0.161,0.763,-6.3,3.3
ENSMUSG00000034394,LIF,leukemia inhibitory factor,extracellular space|cytoplasm|,blood vessel remodeling|transcription from RNA polymerase II promoter|immune response|multicellular organismal development|embryo implantation|positive regulation of cell proliferation|negative regulation of cell proliferation|stem cell maintenance|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation of STAT protein|tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of MAPK cascade|positive regulation of macrophage differentiation|negative regulation of meiosis|positive regulation of transcription from RNA polymerase II promoter|decidualization|negative regulation of hormone secretion|lung alveolus development|muscle organ morphogenesis|neuron development|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|lung vasculature development|lung lobe morphogenesis|trophoblast giant cell differentiation|spongiotrophoblast differentiation|negative regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of protein localization to nucleus|positive regulation of histone H3-K27 acetylation|,RNA polymerase II transcription factor recruiting transcription factor activity|receptor binding|cytokine activity|leukemia inhibitory factor receptor binding|leukemia inhibitory factor receptor binding|growth factor activity|,10,-2.6,1.35,10,0.8,0.48,0.3,0.161,0.763,-7.6,3.4
ENSMUSG00000043510,HSCB,HscB mitochondrial iron-sulfur cluster co-chaperone,cytoplasm|mitochondrion|mitochondrion|centrosome|plasma membrane|,protein folding|iron-sulfur cluster assembly|protein oligomerization|,molecular_function|protein binding|metal ion binding|chaperone binding|,0,0,0,1,0.7,0.174,0.7,0.159,0.764,-1.8,2
ENSMUSG00000009216,FAM163B,"family with sequence similarity 163, member B",integral component of membrane|,None,None,0,0,0,1,-1.1,0.173,-1.1,0.158,0.765,-2,1.8
ENSMUSG00000030243,RECQL,RecQ helicase-like,nucleus|membrane|,DNA strand renaturation|ATP catabolic process|DNA replication|DNA repair|DNA recombination|DNA duplex unwinding|DNA duplex unwinding|DNA duplex unwinding|,DNA binding|DNA helicase activity|ATP-dependent DNA helicase activity|protein binding|ATP binding|annealing helicase activity|ATP-dependent 3'-5' DNA helicase activity|,1,0.1,0.00808,1,1,0.292,0.7,0.158,0.765,-1.8,2
ENSMUSG00000007836,HNRNPA0,heterogeneous nuclear ribonucleoprotein A0,nucleus|nucleoplasm|ribonucleoprotein complex|,"mRNA splicing, via spliceosome|mRNA processing|inflammatory response|RNA splicing|gene expression|response to lipopolysaccharide|3'-UTR-mediated mRNA stabilization|3'-UTR-mediated mRNA stabilization|",nucleotide binding|RNA binding|AU-rich element binding|protein kinase binding|poly(A) RNA binding|,10,0.3,0.155,10,1.7,0.519,0.4,0.158,0.765,-6.3,4.2
ENSMUSG00000043583,4930470P17RIK,RIKEN cDNA 4930470P17 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1.1,0.173,-1.1,0.158,0.765,-2,1.8
ENSMUSG00000046731,KCTD11,potassium channel tetramerization domain containing 11,cytoplasm|,cell cycle|negative regulation of neuroblast proliferation|protein ubiquitination|regulation of growth|positive regulation of neuron differentiation|negative regulation of smoothened signaling pathway|protein homooligomerization|,None,10,-0.9,0.813,10,0,0,-0.5,0.158,0.765,-2.9,1.9
ENSMUSG00000027602,MAP1LC3A,microtubule-associated protein 1 light chain 3 alpha,autophagic vacuole membrane|late endosome|autophagic vacuole|cytosol|microtubule|organelle membrane|cytoplasmic vesicle|,autophagic vacuole assembly|mitochondrion degradation|,protein binding|phospholipid binding|phosphatidylethanolamine binding|,10,-0.3,0.182,10,2.3,0.916,-0.3,0.157,0.765,-3.8,5.6
ENSMUSG00000074651,MCIDAS,multiciliate differentiation and DNA synthesis associated cell cycle protein,nucleus|,"regulation of DNA replication|transcription, DNA-templated|cell cycle|regulation of mitotic cell cycle|cilium assembly|positive regulation of transcription from RNA polymerase II promoter|",protein binding|identical protein binding|,0,0,0,1,0.7,0.172,0.7,0.157,0.765,-1.8,2
ENSMUSG00000073489,IFI204,interferon activated gene 204,nucleus|nucleoplasm|nucleolus|cytoplasm|membrane|nuclear speck|,regulation of transcription from RNA polymerase II promoter|cellular response to interferon-beta|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of osteoblast differentiation|inner ear development|regulation of RNA biosynthetic process|,double-stranded DNA binding|double-stranded DNA binding|transcription cofactor activity|protein binding|transcription factor binding|poly(A) RNA binding|,10,0.2,0.0864,10,-0.3,0.102,0.2,0.156,0.766,-8.8,3.6
ENSMUSG00000020085,AIFM2,"apoptosis-inducing factor, mitochondrion-associated, 2",extracellular space|cytoplasm|mitochondrion|mitochondrial outer membrane|lipid particle|cytosol|integral component of membrane|,apoptotic mitochondrial changes|positive regulation of apoptotic process|positive regulation of apoptotic process|oxidation-reduction process|,DNA binding|electron-transferring-flavoprotein dehydrogenase activity|NADH dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding|,10,1.2,0.779,10,0,0,0.4,0.154,0.767,-2.6,4.4
ENSMUSG00000060181,SLC35E3,"solute carrier family 35, member E3",integral component of membrane|,None,None,10,-0.7,0.394,10,0,0,-0.4,0.154,0.767,-5.1,2.6
ENSMUSG00000030309,CAPRIN2,caprin family member 2,nucleus|cytoplasm|mitochondrion|centrosome|receptor complex|,negative regulation of translation|negative regulation of cell growth|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of canonical Wnt signaling pathway|,RNA binding|receptor binding|protein binding|,0,0,0,1,0.7,0.165,0.7,0.151,0.768,-1.8,2
ENSMUSG00000014606,SLC25A11,"solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11",nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|transport|alpha-ketoglutarate transport|small molecule metabolic process|,oxoglutarate:malate antiporter activity|poly(A) RNA binding|,0,0,0,1,0.7,0.165,0.7,0.151,0.768,-1.8,2
ENSMUSG00000028362,TNFSF8,"tumor necrosis factor (ligand) superfamily, member 8",extracellular space|integral component of plasma membrane|,"apoptotic process|immune response|signal transduction|cell-cell signaling|cell proliferation|CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|defense response to Gram-positive bacterium|",receptor binding|cytokine activity|tumor necrosis factor receptor binding|,10,0.4,0.16,10,0.2,0.0313,0.3,0.151,0.768,-3.2,3
ENSMUSG00000014767,TBP,TATA box binding protein,female pronucleus|male pronucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|nuclear euchromatin|cytoplasm|,"transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|spermatogenesis|cell death|gene expression|viral process|positive regulation of transcription, DNA-templated|",RNA polymerase II repressing transcription factor binding|protein binding|transcription factor binding|transcription regulatory region DNA binding|repressing transcription factor binding|,10,3.9,0.485,9,-1.6,0.0141,-1.3,0.149,0.769,-6.5,7.4
ENSMUSG00000001506,COL1A1,"collagen, type I, alpha 1",extracellular region|collagen type I trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|,"skeletal system development|blood vessel development|osteoblast differentiation|intramembranous ossification|endochondral ossification|response to nutrient|blood coagulation|visual perception|sensory perception of sound|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|protein transport|extracellular matrix disassembly|platelet activation|extracellular matrix organization|collagen fibril organization|positive regulation of cell migration|collagen catabolic process|response to corticosteroid|response to estradiol|collagen biosynthetic process|protein localization to nucleus|tooth mineralization|response to hydrogen peroxide|response to peptide hormone|skin morphogenesis|positive regulation of transcription, DNA-templated|embryonic skeletal system development|leukocyte migration|response to cAMP|face morphogenesis|bone trabecula formation|cartilage development involved in endochondral bone morphogenesis|protein heterotrimerization|cellular response to amino acid stimulus|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|",extracellular matrix structural constituent|protein binding|identical protein binding|metal ion binding|platelet-derived growth factor binding|,10,4.6,0.875,10,0,0,0.2,0.148,0.77,-3,9.4
ENSMUSG00000078185,CHML,choroideremia-like (Rab escort protein 2),cytosol|Rab-protein geranylgeranyltransferase complex|,intracellular protein transport|protein geranylgeranylation|protein geranylgeranylation|positive regulation of GTPase activity|,Rab geranylgeranyltransferase activity|GTPase activator activity|Rab GTPase binding|Rab GTPase binding|,0,0,0,1,-1.1,0.16,-1.1,0.146,0.771,-2,1.8
ENSMUSG00000025235,BBS4,Bardet-Biedl syndrome 4,pericentriolar material|centrosome|centriole|cilium|nonmotile primary cilium|motile cilium|centriolar satellite|BBSome|ciliary basal body|ciliary membrane|,microtubule cytoskeleton organization|mitotic cytokinesis|neural tube closure|retina homeostasis|heart looping|negative regulation of systemic arterial blood pressure|spermatid development|visual perception|sensory perception of smell|metabolic process|negative regulation of gene expression|protein transport|dendrite development|regulation of lipid metabolic process|striatum development|hippocampus development|cerebral cortex development|adult behavior|melanosome transport|regulation of cytokinesis|protein localization to organelle|microtubule anchoring at centrosome|nonmotile primary cilium assembly|negative regulation of appetite by leptin-mediated signaling pathway|positive regulation of multicellular organism growth|cilium assembly|fat cell differentiation|photoreceptor cell maintenance|positive regulation of cilium assembly|retinal rod cell development|intracellular transport|brain morphogenesis|sensory processing|centrosome organization|maintenance of protein location in nucleus|pigment granule aggregation in cell center|convergent extension involved in gastrulation|cilium morphogenesis|regulation of cilium beat frequency involved in ciliary motility|protein localization to centrosome|,RNA polymerase II repressing transcription factor binding|microtubule motor activity|protein binding|dynactin binding|alpha-tubulin binding|beta-tubulin binding|,10,-2.1,0.00698,10,1.4,0.689,0.7,0.146,0.771,-5.4,6.5
ENSMUSG00000059878,ZFP422,zinc finger protein 422,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|odontogenesis|",nucleic acid binding|DNA binding|metal ion binding|,0,0,0,1,-1.1,0.16,-1.1,0.146,0.771,-2,1.8
ENSMUSG00000059921,UNC5C,unc-5 homolog C (C. elegans),plasma membrane|integral component of membrane|,apoptotic process|axon guidance|brain development|regulation of cell migration|anterior/posterior axon guidance|netrin-activated signaling pathway|positive regulation of apoptotic process|,netrin receptor activity|,10,0,0,10,-2.7,1.07,-1.7,0.146,0.771,-6.9,2.4
ENSMUSG00000032698,LMO2,LIM domain only 2 (rhombotin-like 1),nucleus|transcription factor complex|,multicellular organismal development|embryonic hemopoiesis|mRNA transcription from RNA polymerase II promoter|negative regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|cellular response to thyroid hormone stimulus|,RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|protein binding|zinc ion binding|bHLH transcription factor binding|cofactor binding|E-box binding|,10,-0.4,0.39,10,0,0,-0.3,0.146,0.771,-3.6,2.7
ENSMUSG00000026114,CNGA3,cyclic nucleotide gated channel alpha 3,cytoplasm|integral component of plasma membrane|dendrite|photoreceptor outer segment membrane|perikaryon|transmembrane transporter complex|,"transport|cation transport|signal transduction|visual perception|phototransduction, visible light|response to corticosteroid|response to magnesium ion|regulation of membrane potential|retinal cone cell development|response to cAMP|potassium ion transmembrane transport|",intracellular cAMP activated cation channel activity|intracellular cGMP activated cation channel activity|intracellular cGMP activated cation channel activity|voltage-gated potassium channel activity|ligand-gated ion channel activity|cGMP binding|cGMP binding|,0,0,0,1,-1.1,0.16,-1.1,0.146,0.771,-2,1.8
ENSMUSG00000032177,PDE4A,"phosphodiesterase 4A, cAMP-specific",cytosol|membrane|ruffle membrane|perinuclear region of cytoplasm|,cAMP catabolic process|cAMP catabolic process|cAMP catabolic process|cAMP catabolic process|signal transduction|sensory perception of smell|regulation of protein kinase A signaling|cellular response to drug|regulation of cAMP-mediated signaling|,"3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|cAMP binding|metal ion binding|",10,-1,0.684,10,-0.1,0.00346,-0.5,0.146,0.771,-3.8,2.5
ENSMUSG00000096014,SOX1,SRY (sex determining region Y)-box 1,nucleus|,"neuron migration|lens morphogenesis in camera-type eye|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|ventral spinal cord interneuron specification|forebrain neuron development|",core promoter sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,0,0,0,1,-1.1,0.16,-1.1,0.146,0.771,-2,1.8
ENSMUSG00000031886,CES2E,carboxylesterase 2E,cellular_component|endoplasmic reticulum|intracellular membrane-bounded organelle|,None,hydrolase activity|carboxylic ester hydrolase activity|,0,0,0,1,-1.1,0.16,-1.1,0.146,0.771,-2,1.8
ENSMUSG00000034342,CBL,"Cbl proto-oncogene, E3 ubiquitin protein ligase",nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|flotillin complex|,"regulation of transcription, DNA-templated|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|fibroblast growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase signaling|protein ubiquitination|protein ubiquitination|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|positive regulation of receptor-mediated endocytosis|",phosphotyrosine binding|sequence-specific DNA binding transcription factor activity|ubiquitin-protein transferase activity|signal transducer activity|calcium ion binding|protein binding|zinc ion binding|ligase activity|SH3 domain binding|ephrin receptor binding|,10,0.7,0.278,10,0.1,0.0118,0.3,0.146,0.771,-5.1,4.3
ENSMUSG00000058152,CHSY3,chondroitin sulfate synthase 3,Golgi membrane|integral component of membrane|Golgi cisterna membrane|,carbohydrate metabolic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|,metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|,10,-1.8,0.017,10,2.8,2.27,0.3,0.144,0.772,-4.7,6
ENSMUSG00000031372,TREX2,three prime repair exonuclease 2,nucleus|,"DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|DNA metabolic process|DNA repair|",magnesium ion binding|nucleic acid binding|3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|protein homodimerization activity|,10,0.7,0.384,10,0,0,0.6,0.144,0.772,-4.9,4
ENSMUSG00000026567,ADCY10,adenylate cyclase 10 (soluble),cytoplasm|cytosol|cytoskeleton|plasma membrane|axon|dendrite|growth cone|neuronal cell body|apical part of cell|basal part of cell|perinuclear region of cytoplasm|,cAMP biosynthetic process|spermatogenesis|intracellular signal transduction|positive regulation of apoptotic process|,magnesium ion binding|adenylate cyclase activity|ATP binding|manganese ion binding|ATPase binding|,9,2.1,2.43,10,0,0,-0.5,0.144,0.772,-10.2,6
ENSMUSG00000030255,SSPN,sarcospan,integral component of plasma membrane|dystrophin-associated glycoprotein complex|cell junction|transport vesicle|sarcolemma|postsynaptic membrane|,muscle contraction|cell adhesion|,None,1,1,0.374,1,-0.7,0.0968,0.8,0.144,0.772,-1.9,2.9
ENSMUSG00000018507,TRPV2,"transient receptor potential cation channel, subfamily V, member 2",plasma membrane|plasma membrane|integral component of plasma membrane|cell surface|endomembrane system|growth cone membrane|melanosome|axonal growth cone|cell body|,transport|sensory perception|response to temperature stimulus|response to heat|ion transmembrane transport|positive regulation of axon extension|transmembrane transport|calcium ion transmembrane transport|positive regulation of calcium ion import|,ion channel activity|cation channel activity|calcium channel activity|ion transmembrane transporter activity|,10,1.7,0.888,10,0.2,0.0686,0.3,0.143,0.772,-2.3,5.5
ENSMUSG00000031595,PDGFRL,platelet-derived growth factor receptor-like,cellular_component|extracellular region|,G-protein coupled receptor signaling pathway|biological_process|platelet-derived growth factor receptor-beta signaling pathway|,platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|,10,-0.8,0.228,10,-0.1,0.00268,-0.6,0.143,0.772,-6.7,2.6
ENSMUSG00000026641,USF1,upstream transcription factor 1,nucleus|transcription factor complex|,regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|glucose metabolic process|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|response to UV|late viral transcription|cellular response to insulin stimulus|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|carbon catabolite regulation of transcription|negative regulation of fibrinolysis|lipid homeostasis|,double-stranded DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|enzyme binding|protein kinase binding|protein homodimerization activity|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|sequence-specific DNA binding|protein heterodimerization activity|,10,0,0,10,-0.3,0.217,-0.3,0.142,0.773,-9.1,3.2
ENSMUSG00000095754,SPIN2F,"spindlin family, member 2F",cellular_component|,biological_process|,molecular_function|,9,1.1,0.53,9,0,0,0.3,0.142,0.773,-2.6,3.2
ENSMUSG00000022757,TFG,TRK-fused gene,cytoplasm|extracellular vesicular exosome|,signal transduction|cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|,signal transducer activity|protein binding|identical protein binding|,9,0,0,10,-0.7,0.765,-0.3,0.142,0.773,-8.2,5
ENSMUSG00000006288,TTC5,tetratricopeptide repeat domain 5,nucleus|cytoplasm|,DNA repair|positive regulation of transcription from RNA polymerase II promoter|,DNA binding|chromatin binding|,10,0,0,10,-0.5,0.287,-0.3,0.141,0.773,-5.8,4.3
ENSMUSG00000021224,NUMB,numb homolog (Drosophila),nucleus|early endosome|plasma membrane|integral component of plasma membrane|basolateral plasma membrane|extrinsic component of plasma membrane|apical part of cell|,Notch signaling pathway|axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of polarized epithelial cell differentiation|adherens junction organization|negative regulation of Notch signaling pathway|positive regulation of neurogenesis|lung epithelial cell differentiation|,protein binding|beta-catenin binding|alpha-catenin binding|cadherin binding|,10,-0.7,0.552,10,0,0,-0.4,0.141,0.773,-8.7,2
ENSMUSG00000037171,NODAL,nodal growth differentiation factor,extracellular space|,negative regulation of transcription from RNA polymerase II promoter|trophectodermal cellular morphogenesis|neural fold formation|liver development|placenta development|embryonic placenta development|maternal placenta development|vasculature development|heart looping|inhibition of neuroepithelial cell differentiation|brain development|embryonic pattern specification|polarity specification of proximal/distal axis|regulation of gastrulation|positive regulation vascular endothelial growth factor production|positive regulation of pathway-restricted SMAD protein phosphorylation|stem cell maintenance|positive regulation of cell-cell adhesion|positive regulation of activin receptor signaling pathway|floor plate morphogenesis|endodermal cell differentiation|growth|cell migration involved in gastrulation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|axial mesodermal cell fate specification|mesendoderm development|digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|formation of anatomical boundary|positive regulation of epithelial cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|embryonic process involved in female pregnancy|maternal process involved in parturition|positive regulation of SMAD protein import into nucleus|SMAD protein signal transduction|left lung morphogenesis|negative regulation of androgen receptor signaling pathway|epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification|positive regulation of ERK1 and ERK2 cascade|transforming growth factor beta receptor signaling pathway involved in primitive streak formation|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation|regulation of stem cell maintenance|,cytokine activity|growth factor activity|morphogen activity|receptor agonist activity|type I activin receptor binding|,10,0.9,0.797,10,0,0,0.5,0.14,0.774,-2.6,3.7
ENSMUSG00000059280,VPREB2,pre-B lymphocyte gene 2,None,cell morphogenesis|regulation of cell size|B cell proliferation|homeostasis of number of cells|,None,10,0,0,10,-0.8,1.08,-0.5,0.14,0.774,-8.6,1.4
ENSMUSG00000019124,SCRN1,secernin 1,nucleus|cytoplasm|nuclear membrane|,proteolysis|exocytosis|,molecular_function|dipeptidase activity|,0,0,0,1,-1,0.153,-1,0.139,0.774,-2,1.8
ENSMUSG00000020486,4-Sep,septin 4,nucleus|mitochondrion|cytoskeleton|motile cilium|,cytokinesis|GTP catabolic process|apoptotic process|brain development|sperm mitochondrion organization|positive regulation of protein ubiquitination|regulation of apoptotic process|positive regulation of apoptotic process|sperm capacitation|positive regulation of intrinsic apoptotic signaling pathway|,GTPase activity|structural molecule activity|protein binding|GTP binding|,10,-0.2,0.0247,10,-0.6,0.183,-0.4,0.139,0.774,-7.8,5.7
ENSMUSG00000020635,FKBP1B,"FK506 binding protein 1B, 12.6 kDa",cytoplasm|cytosol|membrane|Z disc|sarcoplasmic reticulum membrane|calcium channel complex|,protein peptidyl-prolyl isomerization|'de novo' protein folding|smooth muscle contraction|response to glucose|negative regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|neuronal action potential propagation|protein maturation by protein folding|insulin secretion|negative regulation of protein phosphatase type 2B activity|response to vitamin E|calcium-mediated signaling using intracellular calcium source|protein refolding|T cell proliferation|response to hydrogen peroxide|positive regulation of axon regeneration|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|cytosolic calcium ion homeostasis|cytosolic calcium ion homeostasis|response to redox state|regulation of ryanodine-sensitive calcium-release channel activity|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|chaperone-mediated protein folding|negative regulation of insulin secretion involved in cellular response to glucose stimulus|calcium ion transmembrane transport|cell communication by electrical coupling involved in cardiac conduction|,peptidyl-prolyl cis-trans isomerase activity|receptor binding|ryanodine-sensitive calcium-release channel activity|protein binding|FK506 binding|calcium channel inhibitor activity|cyclic nucleotide binding|ion channel binding|,0,0,0,1,0.7,0.152,0.7,0.138,0.775,-1.8,2
ENSMUSG00000020679,HNF1B,HNF1 homeobox B,nucleus|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|endodermal cell fate specification|kidney development|kidney development|inner cell mass cell differentiation|transcription from RNA polymerase II promoter|response to glucose|anterior/posterior pattern specification|insulin secretion|regulation of Wnt signaling pathway|hindbrain development|endocrine pancreas development|endocrine pancreas development|regulation of pronephros size|pronephric nephron tubule development|regulation of endodermal cell fate specification|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract morphogenesis|branching morphogenesis of an epithelial tube|pronephros development|genitalia development|epithelial cell proliferation|positive regulation of transcription initiation from RNA polymerase II promoter|ureteric bud elongation|hepatoblast differentiation|negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis|regulation of branch elongation involved in ureteric bud branching|mesonephric duct formation|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|",DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|protein homodimerization activity|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|,10,-0.5,0.457,10,0,0,-0.3,0.138,0.775,-4.3,2.7
ENSMUSG00000045532,C1QL1,"complement component 1, q subcomponent-like 1",cellular_component|extracellular region|collagen trimer|cytoplasm|,locomotory behavior|,molecular_function|,9,0.8,0.365,10,-0.8,0.507,1,0.138,0.775,-5.9,7.3
ENSMUSG00000020241,COL6A2,"collagen, type VI, alpha 2",extracellular region|extracellular region|proteinaceous extracellular matrix|collagen trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|sarcolemma|protein complex|extracellular vesicular exosome|,cell adhesion|axon guidance|response to glucose|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|protein heterotrimerization|,protein binding|,10,0.7,0.38,10,-0.6,0.425,-0.6,0.138,0.775,-7.1,6.5
ENSMUSG00000033834,TPBPA,trophoblast specific protein alpha,extracellular region|intracellular|,JNK cascade|cellular response to organic cyclic compound|,molecular_function|cysteine-type peptidase activity|,10,-2.9,1.07,10,2.5,2.15,1.4,0.136,0.776,-7.1,6.7
ENSMUSG00000006215,ZBTB17,zinc finger and BTB domain containing 17,nucleoplasm|,"gastrulation with mouth forming second|transcription, DNA-templated|activation of signaling protein activity involved in unfolded protein response|ectoderm development|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|metal ion binding|,10,0,0,10,-0.4,0.178,-0.3,0.136,0.776,-3.9,1.7
ENSMUSG00000050493,FAM167B,"family with sequence similarity 167, member B",None,None,None,1,-0.6,0.149,0,0,0,-0.6,0.136,0.776,-2,1.8
ENSMUSG00000049353,RD3,retinal degeneration 3,None,visual perception|response to stimulus|retina development in camera-type eye|,None,0,0,0,1,-1,0.148,-1,0.135,0.777,-2,1.8
ENSMUSG00000026270,CAPN10,calpain 10,cell|mitochondrion|cytosol|cytosol|plasma membrane|,proteolysis|cellular component disassembly involved in execution phase of apoptosis|actin cytoskeleton reorganization|positive regulation of insulin secretion|positive regulation of intracellular transport|cellular response to insulin stimulus|positive regulation of glucose import|type B pancreatic cell apoptotic process|positive regulation of type B pancreatic cell apoptotic process|,SNARE binding|calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|,10,-0.2,0.0306,10,-1.8,0.759,-0.8,0.135,0.777,-6.4,2.9
ENSMUSG00000027442,CST8,cystatin 8 (cystatin-related epididymal specific),extracellular region|cytoplasm|cell surface|,negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|,cysteine-type endopeptidase inhibitor activity|,10,-0.7,0.498,10,0,0,-0.4,0.135,0.777,-3.4,2.1
ENSMUSG00000000056,NARF,nuclear prelamin A recognition factor,nucleus|lamin filament|nuclear lamina|nuclear lumen|,None,lamin binding|,0,0,0,1,-1,0.148,-1,0.135,0.777,-2,1.8
ENSMUSG00000002083,BBC3,BCL2 binding component 3,mitochondrion|mitochondrion|mitochondrial outer membrane|cytosol|,release of cytochrome c from mitochondria|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|determination of adult lifespan|positive regulation of protein homooligomerization|negative regulation of endoplasmic reticulum calcium ion concentration|response to endoplasmic reticulum stress|positive regulation of neuron apoptotic process|negative regulation of growth|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of thymocyte apoptotic process|cellular response to hypoxia|positive regulation of release of cytochrome c from mitochondria|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of cysteine-type endopeptidase activity|positive regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|,10,-0.3,0.102,10,-0.3,0.0471,-0.3,0.135,0.777,-3.2,2.4
ENSMUSG00000024525,IMPA2,inositol(myo)-1(or 4)-monophosphatase 2,cytoplasm|cytosol|,inositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol phosphate metabolic process|small molecule metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|,inositol monophosphate 1-phosphatase activity|protein homodimerization activity|metal ion binding|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|,10,0.1,0.0112,10,0.3,0.14,0.3,0.134,0.777,-2.8,3.5
ENSMUSG00000020205,PHLDA1,"pleckstrin homology-like domain, family A, member 1",nucleolus|cytoplasmic vesicle membrane|,apoptotic process|forebrain neuron differentiation|positive regulation of apoptotic process|FasL biosynthetic process|,protein binding|,10,0,0,10,0.6,0.733,0.3,0.134,0.777,-2,3.5
ENSMUSG00000005150,WDR83,WD repeat domain 83,spliceosomal complex|cytoplasm|catalytic step 2 spliceosome|,"RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|",protein binding|,1,0,0,1,-1.7,0.423,-1.5,0.134,0.777,-3,1.7
ENSMUSG00000091337,EID1,EP300 interacting inhibitor of differentiation 1,nucleus|nucleus|cytoplasm|aggresome|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|cell cycle|cell differentiation|regulation of histone acetylation|negative regulation of transcription, DNA-templated|",transcription corepressor activity|protein binding|histone acetyltransferase regulator activity|histone acetyltransferase binding|,9,-2.5,1.47,9,-0.3,0.0901,-0.3,0.131,0.779,-8,2.3
ENSMUSG00000020326,CCNG1,cyclin G1,nucleus|dendrite|neuronal cell body|perinuclear region of cytoplasm|,regulation of cyclin-dependent protein serine/threonine kinase activity|syncytium formation|mitotic nuclear division|mitotic G2 DNA damage checkpoint|brain development|response to organonitrogen compound|cell growth|negative regulation of apoptotic process|,protein binding|protein domain specific binding|,10,-5.8,0.392,10,-0.4,0.189,-0.3,0.131,0.779,-10,3.3
ENSMUSG00000035273,HPSE,heparanase,extracellular region|nucleus|lysosome|lysosomal membrane|lysosomal lumen|intracellular membrane-bounded organelle|membrane raft|,carbohydrate metabolic process|glycosaminoglycan catabolic process|proteoglycan metabolic process|cell-matrix adhesion|positive regulation vascular endothelial growth factor production|positive regulation of blood coagulation|heparan sulfate proteoglycan catabolic process|glycosaminoglycan metabolic process|positive regulation of osteoblast proliferation|small molecule metabolic process|regulation of hair follicle development|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|vascular wound healing|,beta-glucuronidase activity|protein binding|heparanase activity|heparanase activity|syndecan binding|protein dimerization activity|,10,3.4,1.25,10,0,0,0.4,0.131,0.779,-2,6.9
ENSMUSG00000032009,SESN3,sestrin 3,nucleus|,regulation of response to reactive oxygen species|,None,10,-0.5,0.718,10,0,0,-0.3,0.131,0.779,-2,1.4
ENSMUSG00000006362,CBFA2T3,"core-binding factor, runt domain, alpha subunit 2; translocated to, 3",Golgi membrane|nucleoplasm|nucleolus|,"transcription, DNA-templated|cell proliferation|granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|",chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|metal ion binding|,10,0,0,10,-1,0.76,-0.3,0.13,0.779,-4.6,2.3
ENSMUSG00000032815,FANCA,"Fanconi anemia, complementation group A",nucleus|nucleoplasm|nucleolus|cytoplasm|Fanconi anaemia nuclear complex|,DNA repair|protein complex assembly|male meiosis|male gonad development|female gonad development|regulation of cell proliferation|,protein binding|,10,-0.2,0.0138,10,-0.4,0.144,-0.3,0.129,0.78,-4.1,2.9
ENSMUSG00000075706,GPX4,glutathione peroxidase 4,nucleus|nuclear envelope|mitochondrion|mitochondrial inner membrane|cytosol|extracellular vesicular exosome|,chromatin organization|phospholipid metabolic process|glutathione metabolic process|multicellular organismal development|spermatogenesis|aging|arachidonic acid metabolic process|lipoxygenase pathway|response to estradiol|hydrogen peroxide catabolic process|small molecule metabolic process|regulation of inflammatory response|oxidation-reduction process|,glutathione peroxidase activity|selenium binding|glutathione binding|phospholipid-hydroperoxide glutathione peroxidase activity|,10,0,0,10,-1.1,0.928,-0.4,0.127,0.781,-3.8,2.4
ENSMUSG00000010797,WNT2,wingless-type MMTV integration site family member 2,extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|plasma membrane|extracellular matrix|,positive regulation of endothelial cell proliferation|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|cell-cell signaling|positive regulation of cell proliferation|Wnt signaling pathway|neuron differentiation|neuron differentiation|lung development|cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|atrial cardiac muscle tissue morphogenesis|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|cardiac epithelial to mesenchymal transition|lung induction|positive regulation of epithelial cell proliferation involved in lung morphogenesis|labyrinthine layer blood vessel development|iris morphogenesis|mammary gland epithelium development|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|,frizzled binding|cytokine activity|protein binding|receptor agonist activity|,10,0,0,10,-0.5,0.468,-0.2,0.127,0.781,-9.2,3.5
ENSMUSG00000024191,BNIP1,BCL2/adenovirus E1B 19kDa interacting protein 1,nuclear envelope|cytoplasm|mitochondrion|endoplasmic reticulum|integral component of endoplasmic reticulum membrane|SNARE complex|intracellular membrane-bounded organelle|,autophagy|apoptotic process|endoplasmic reticulum organization|vesicle-mediated transport|endoplasmic reticulum membrane fusion|negative regulation of apoptotic process|execution phase of apoptosis|,SNAP receptor activity|protein binding|,10,0,0,10,-0.9,0.504,-0.2,0.127,0.781,-6.6,3.3
ENSMUSG00000033417,CACUL1,"CDK2-associated, cullin domain 1",cullin-RING ubiquitin ligase complex|,G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process|positive regulation of cell proliferation|positive regulation of protein kinase activity|,protein binding|protein kinase binding|ubiquitin protein ligase binding|,10,0,0,10,0.7,0.671,0.3,0.126,0.781,-2.6,4.6
ENSMUSG00000000184,CCND2,cyclin D2,cyclin-dependent protein kinase holoenzyme complex|chromatin|nucleus|nucleolus|cytosol|nuclear membrane|,positive regulation of protein phosphorylation|cell cycle|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|,protein binding|protein kinase binding|,10,-0.7,0.571,10,0,0,-0.4,0.126,0.781,-5,2.2
ENSMUSG00000037119,D15ERTD621E,"DNA segment, Chr 15, ERATO Doi 621, expressed",cellular_component|,biological_process|,molecular_function|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000057440,MPP7,"membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)",mitochondrion|adherens junction|tight junction|cell junction|MPP7-DLG1-LIN7 complex|,positive regulation of signal transduction|positive regulation of signal transduction|establishment of cell polarity|positive regulation of protein complex assembly|positive regulation of protein complex assembly|tight junction assembly|protein localization to adherens junction|,protein binding|protein domain specific binding|protein complex scaffold|signaling adaptor activity|signaling adaptor activity|protein heterodimerization activity|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000020867,SPATA20,spermatogenesis associated 20,extracellular region|,multicellular organismal development|spermatogenesis|metabolic process|cell differentiation|,catalytic activity|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000044306,4930500M09RIK,N/A,None,None,None,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000045515,POU3F3,POU class 3 homeobox 3,nucleus|,"transcription, DNA-templated|central nervous system development|positive regulation of cell proliferation|positive regulation of gene expression|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metanephric ascending thin limb development|metanephric macula densa development|metanephric thick ascending limb development|metanephric loop of Henle development|metanephric DCT cell differentiation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|HMG box domain binding|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000083649,RASL2-9,"RAS-like, family 2, locus 9",nucleus|,GTP catabolic process|transport|intracellular protein transport|nucleocytoplasmic transport|signal transduction|small GTPase mediated signal transduction|protein transport|,nucleotide binding|GTPase activity|GTP binding|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000028550,ATG4C,"autophagy related 4C, cysteine peptidase",extracellular region|cytoplasm|cytosol|,autophagic vacuole assembly|proteolysis|protein targeting to membrane|autophagy|,cysteine-type endopeptidase activity|peptidase activity|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000065954,TACC1,"transforming, acidic coiled-coil containing protein 1",nucleus|cytoplasm|microtubule organizing center|microtubule cytoskeleton|intermediate filament cytoskeleton|,microtubule cytoskeleton organization|cell cycle|cerebral cortex development|neurogenesis|interkinetic nuclear migration|regulation of microtubule-based process|cell division|,protein binding|protein domain specific binding|,10,1.7,1.03,10,-0.7,0.725,-0.3,0.125,0.782,-4.4,5.1
ENSMUSG00000023827,AGPAT4,1-acylglycerol-3-phosphate O-acyltransferase 4,endoplasmic reticulum membrane|integral component of membrane|,phospholipid metabolic process|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|glycerophospholipid biosynthetic process|,1-acylglycerol-3-phosphate O-acyltransferase activity|,0,0,0,1,-1,0.137,-1,0.125,0.782,-2,1.8
ENSMUSG00000016181,DIEXF,digestive organ expansion factor homolog (zebrafish),nucleolus|,multicellular organismal development|,poly(A) RNA binding|,0,0,0,1,-1,0.136,-1,0.124,0.783,-2,1.8
ENSMUSG00000035437,RABGAP1,RAB GTPase activating protein 1,centrosome|cytosol|microtubule associated complex|,cell cycle|positive regulation of Rab GTPase activity|positive regulation of GTPase activity|,DNA binding|GTPase activator activity|Rab GTPase activator activity|protein binding|tubulin binding|,10,-0.3,0.125,10,-0.1,0.0339,-0.2,0.124,0.783,-4.2,2
ENSMUSG00000021235,COQ6,coenzyme Q6 monooxygenase,mitochondrion|Golgi apparatus|cell projection|,ubiquinone biosynthetic process|ubiquinone biosynthetic process|small molecule metabolic process|oxidation-reduction process|,"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|flavin adenine dinucleotide binding|",10,-0.4,0.0611,10,-0.2,0.0784,-0.3,0.123,0.783,-5,2
ENSMUSG00000030231,PLEKHA5,"pleckstrin homology domain containing, family A member 5",cellular_component|cytoplasm|membrane|,biological_process|,protein binding|1-phosphatidylinositol binding|,0,0,0,1,0.6,0.134,0.6,0.122,0.784,-1.8,2
ENSMUSG00000056215,LRGUK,leucine-rich repeats and guanylate kinase domain containing,nucleus|cytoplasm|,phosphorylation|,ATP binding|kinase activity|,9,0.4,0.194,9,0,0,0.3,0.122,0.784,-2.8,5.3
ENSMUSG00000054106,TRY4,trypsin 4,extracellular space|extracellular vesicular exosome|,proteolysis|,serine-type endopeptidase activity|calcium ion binding|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,4.4,0.85,10,0.2,0.0412,0.2,0.122,0.784,-3,8.5
ENSMUSG00000018924,ALOX15,arachidonate 15-lipoxygenase,lipid particle|cytosol|cytosol|cytosol|plasma membrane|membrane|extrinsic component of cytoplasmic side of plasma membrane|,ossification|negative regulation of adaptive immune response|phosphatidylethanolamine biosynthetic process|leukotriene metabolic process|inflammatory response|positive regulation of cell-substrate adhesion|arachidonic acid metabolic process|arachidonic acid metabolic process|arachidonic acid metabolic process|lipoxygenase pathway|lipoxygenase pathway|bone mineralization|positive regulation of actin filament polymerization|response to endoplasmic reticulum stress|regulation of peroxisome proliferator activated receptor signaling pathway|cellular response to interleukin-13|wound healing|apoptotic cell clearance|small molecule metabolic process|hepoxilin biosynthetic process|oxidation-reduction process|positive regulation of ERK1 and ERK2 cascade|cellular response to calcium ion|regulation of engulfment of apoptotic cell|lipoxin A4 biosynthetic process|,"arachidonate 12-lipoxygenase activity|iron ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|arachidonate 15-lipoxygenase activity|arachidonate 15-lipoxygenase activity|eoxin A4 synthase activity|",10,0.5,0.238,10,-0.8,0.581,-0.6,0.121,0.784,-3.6,3.3
ENSMUSG00000049502,DTX3L,"deltex 3 like, E3 ubiquitin ligase",nucleus|cytoplasm|,double-strand break repair|cellular response to DNA damage stimulus|histone monoubiquitination|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|histone binding|,10,0.2,0.0339,10,0.3,0.108,0.2,0.121,0.784,-4.1,4.4
ENSMUSG00000028965,TNFRSF9,"tumor necrosis factor receptor superfamily, member 9",extracellular space|integral component of plasma membrane|external side of plasma membrane|,apoptotic process|negative regulation of cell proliferation|protein homotrimerization|negative regulation of interleukin-10 secretion|negative regulation of interleukin-12 secretion|,receptor activity|cytokine binding|,10,0,0,10,-0.4,0.243,-0.2,0.119,0.785,-4,1.7
ENSMUSG00000056910,VMN2R107,"vomeronasal 2, receptor 107",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,10,-5.5,1.66,10,0.8,0.821,0.3,0.119,0.785,-9.6,2.8
ENSMUSG00000036503,RNF13,ring finger protein 13,Golgi membrane|nuclear inner membrane|lysosomal membrane|lysosomal membrane|endoplasmic reticulum membrane|integral component of membrane|late endosome membrane|,protein autoubiquitination|,ubiquitin-protein transferase activity|zinc ion binding|ligase activity|,10,-1.6,0.0303,10,0.9,0.282,0.3,0.119,0.785,-5.8,6.6
ENSMUSG00000030086,CHCHD6,coiled-coil-helix-coiled-coil-helix domain containing 6,mitochondrion|mitochondrial inner membrane|,cellular response to DNA damage stimulus|cristae formation|,protein binding|,0,0,0,1,0.6,0.129,0.6,0.118,0.786,-1.8,2
ENSMUSG00000021594,SRD5A1,"steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)",endoplasmic reticulum membrane|integral component of membrane|,androgen biosynthetic process|sex determination|sex differentiation|steroid metabolic process|cell differentiation|small molecule metabolic process|oxidation-reduction process|,3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity|cholestenone 5-alpha-reductase activity|,9,-2.8,2.33,9,0,0,0.3,0.118,0.786,-6,8.9
ENSMUSG00000037316,BAG4,BCL2-associated athanogene 4,nucleus|cytosol|plasma membrane|,"protein folding|positive regulation of fibroblast migration|positive regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|negative regulation of apoptotic process|positive regulation of cell adhesion|protein heterooligomerization|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of mRNA modification|ruffle assembly|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|",receptor signaling protein activity|poly(A) RNA binding|chaperone binding|,0,0,0,1,-0.9,0.128,-0.9,0.117,0.786,-2,1.8
ENSMUSG00000097585,GM26529,N/A,None,None,None,0,0,0,1,-0.9,0.128,-0.9,0.117,0.786,-2,1.8
ENSMUSG00000017548,SUZ12,SUZ12 polycomb repressive complex 2 subunit,sex chromatin|nucleus|nucleoplasm|ESC/E(Z) complex|ESC/E(Z) complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|positive regulation of cell proliferation|histone methylation|histone ubiquitination|negative regulation of cell differentiation|",chromatin binding|protein binding|methylated histone binding|histone methyltransferase activity|sequence-specific DNA binding|metal ion binding|,10,-0.8,0.337,10,-0.1,0.0147,-0.3,0.117,0.786,-4.6,4
ENSMUSG00000036151,TM6SF2,transmembrane 6 superfamily member 2,integral component of membrane|,biological_process|,molecular_function|,10,-1.8,0.697,10,-0.1,0.00367,-0.5,0.116,0.787,-6.7,3.2
ENSMUSG00000009246,TRPM5,"transient receptor potential cation channel, subfamily M, member 5",plasma membrane|integral component of membrane|,ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|transmembrane transport|calcium ion transmembrane transport|potassium ion transmembrane transport|,ion channel activity|calcium activated cation channel activity|voltage-gated ion channel activity|potassium channel activity|sodium channel activity|,0,0,0,1,-0.9,0.127,-0.9,0.115,0.788,-2,1.8
ENSMUSG00000047045,TMEM164,transmembrane protein 164,integral component of membrane|,None,None,0,0,0,1,-0.9,0.127,-0.9,0.115,0.788,-2,1.8
ENSMUSG00000021097,CLMN,"calmin (calponin-like, transmembrane)",cytoplasm|integral component of membrane|,negative regulation of cell proliferation|neuron projection development|,actin binding|,0,0,0,1,-0.9,0.127,-0.9,0.115,0.788,-2,1.8
ENSMUSG00000029361,NOS1,nitric oxide synthase 1 (neuronal),photoreceptor inner segment|cytoplasm|cytosol|cytoskeleton|sarcoplasmic reticulum|sarcolemma|dendritic spine|protein complex|synapse|perinuclear region of cytoplasm|,response to hypoxia|arginine catabolic process|nitric oxide biosynthetic process|nitric oxide biosynthetic process|striated muscle contraction|nitric oxide mediated signal transduction|myoblast fusion|blood coagulation|response to heat|negative regulation of calcium ion transport into cytosol|peptidyl-cysteine S-nitrosylation|positive regulation of guanylate cyclase activity|multicellular organismal response to stress|positive regulation of histone acetylation|neurotransmitter biosynthetic process|exogenous drug catabolic process|negative regulation of potassium ion transport|negative regulation of blood pressure|positive regulation of vasodilation|positive regulation of vasodilation|positive regulation of transcription from RNA polymerase II promoter|negative regulation of hydrolase activity|negative regulation of serotonin uptake|interaction with host|oxidation-reduction process|regulation of cardiac muscle contraction|cellular response to growth factor stimulus|phagosome maturation|positive regulation of sodium ion transmembrane transport|,NADPH-hemoprotein reductase activity|nitric-oxide synthase activity|nitric-oxide synthase activity|iron ion binding|protein binding|calmodulin binding|FMN binding|oxidoreductase activity|sodium channel regulator activity|heme binding|tetrahydrobiopterin binding|arginine binding|ion channel binding|cadmium ion binding|flavin adenine dinucleotide binding|NADP binding|scaffold protein binding|,10,0,0,10,-0.5,0.344,-0.3,0.115,0.788,-4.9,2
ENSMUSG00000071650,GANAB,"glucosidase, alpha; neutral AB",endoplasmic reticulum lumen|Golgi apparatus|membrane|glucosidase II complex|melanosome|extracellular vesicular exosome|,protein folding|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,"carbohydrate binding|glucan 1,3-alpha-glucosidase activity|poly(A) RNA binding|",10,-0.4,0.267,10,0,0,-0.2,0.115,0.788,-3.4,2.9
ENSMUSG00000020713,GH,growth hormone,extracellular region|extracellular space|extracellular space|nucleus|nucleus|mitochondrion|trans-Golgi network|cytosol|plasma membrane|secretory granule|secretory granule|,signal transduction|neuroblast proliferation|response to light stimulus|glucose transport|response to food|cellular response to insulin stimulus|regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of multicellular organism growth|positive regulation of growth|lung alveolus development|positive regulation of neurogenesis|positive regulation of steroid hormone biosynthetic process|negative regulation of neuron death|,growth hormone receptor binding|growth hormone receptor binding|hormone activity|metal ion binding|,0,0,0,1,-0.9,0.127,-0.9,0.115,0.788,-2,1.8
ENSMUSG00000096210,H1F0,"H1 histone family, member 0",nucleosome|nuclear chromatin|nucleus|nucleoplasm|nuclear euchromatin|Golgi apparatus|actin cytoskeleton|,apoptotic DNA fragmentation|nucleosome assembly|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|,protein binding|chromatin DNA binding|poly(A) RNA binding|,0,0,0,1,-0.9,0.127,-0.9,0.115,0.788,-2,1.8
ENSMUSG00000001128,CFP,complement factor properdin,extracellular region|extracellular space|extracellular matrix|,"immune response|complement activation|complement activation, alternative pathway|regulation of complement activation|defense response to bacterium|innate immune response|",None,10,-1.9,0.186,10,-0.3,0.0967,-0.2,0.115,0.788,-5.7,2.9
ENSMUSG00000050840,CDH20,"cadherin 20, type 2",plasma membrane|integral component of membrane|,homophilic cell adhesion|,calcium ion binding|,10,0,0,10,-0.5,0.21,-0.2,0.114,0.788,-3.6,2.6
ENSMUSG00000047284,NEURL4,neuralized E3 ubiquitin protein ligase 4,centriole|,None,protein binding|,10,-2.5,0.795,10,-0.2,0.04,-0.3,0.114,0.788,-6.5,5.5
ENSMUSG00000069495,EPC2,enhancer of polycomb homolog 2 (Drosophila),Piccolo NuA4 histone acetyltransferase complex|,"DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|chromatin modification|",None,10,-1.6,1.95,10,0,0,-1.4,0.114,0.788,-3.8,1.7
ENSMUSG00000030353,TEAD4,TEA domain family member 4,nucleoplasm|,skeletal system development|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|muscle organ development|gene expression|hippo signaling|,DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,0.9,0.262,10,-0.3,0.0678,-0.4,0.114,0.788,-8.5,4.7
ENSMUSG00000002550,UCK1,uridine-cytidine kinase 1,cytosol|,pyrimidine nucleobase metabolic process|phosphorylation|pyrimidine nucleoside salvage|UMP salvage|CTP salvage|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,uridine kinase activity|ATP binding|nucleoside kinase activity|,10,0.8,0.306,10,-2.7,0.479,0.3,0.112,0.789,-9.5,4
ENSMUSG00000041566,TSSK1,testis-specific serine kinase 1,acrosomal vesicle|cytoplasm|cytoplasmic vesicle|motile cilium|cell projection|,protein phosphorylation|multicellular organismal development|spermatogenesis|spermatid development|phosphorylation|cell differentiation|,"nucleotide binding|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|kinase activity|transferase activity|transferase activity, transferring phosphorus-containing groups|metal ion binding|",10,-1.4,1.18,10,0,0,-1.1,0.112,0.789,-6.5,5.1
ENSMUSG00000050310,RICTOR,"RPTOR independent companion of MTOR, complex 2",cytosol|TORC2 complex|,positive regulation of endothelial cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|embryo development|positive regulation of actin filament polymerization|T cell costimulation|actin cytoskeleton reorganization|TOR signaling|positive regulation of TOR signaling|regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of peptidyl-tyrosine phosphorylation|regulation of protein kinase B signaling|positive regulation of protein kinase B signaling|,protein binding|ribosome binding|,10,-1.7,0.79,9,0.7,0.511,0.3,0.112,0.789,-3.8,4.4
ENSMUSG00000021536,ADCY2,adenylate cyclase 2 (brain),intracellular|cytoplasm|plasma membrane|plasma membrane|membrane|integral component of membrane|dendrite|protein complex|membrane raft|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|adenylate cyclase activity|ATP binding|adenylate cyclase binding|calcium- and calmodulin-responsive adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|metal ion binding|protein heterodimerization activity|,9,0,0,9,-2.4,0.299,-0.2,0.111,0.79,-7.5,2.2
ENSMUSG00000025880,SMAD7,SMAD family member 7,nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|plasma membrane|cell-cell adherens junction|catenin complex|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|gene expression|negative regulation of epithelial to mesenchymal transition|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of transcription by competitive promoter binding|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell-cell adhesion|negative regulation of cell migration|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of activin receptor signaling pathway|negative regulation of peptidyl-serine phosphorylation|adherens junction assembly|response to laminar fluid shear stress|cellular protein complex localization|intracellular signal transduction|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|artery morphogenesis|protein stabilization|negative regulation of ubiquitin-protein transferase activity|ventricular cardiac muscle tissue morphogenesis|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane depolarization|pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|cellular response to transforming growth factor beta stimulus|","sequence-specific DNA binding transcription factor activity|protein binding|collagen binding|beta-catenin binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|ubiquitin protein ligase binding|type I transforming growth factor beta receptor binding|transcription regulatory region DNA binding|metal ion binding|activin binding|I-SMAD binding|",8,-0.2,0.0799,8,-2.7,1.1,-0.2,0.11,0.79,-10.7,3
ENSMUSG00000028702,RAD54L,RAD54-like (S. cerevisiae),nucleus|,double-strand break repair via homologous recombination|DNA strand renaturation|DNA repair|DNA recombination|meiotic nuclear division|response to ionizing radiation|response to drug|chromosome organization|,DNA binding|helicase activity|protein binding|ATP binding|annealing helicase activity|,10,1.2,0.728,10,0,0,0.2,0.11,0.79,-2,5.1
ENSMUSG00000021285,PPP1R13B,"protein phosphatase 1, regulatory subunit 13B",nucleus|cytoplasm|cytoplasm|plasma membrane|,negative regulation of cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|,protein binding|transcription factor binding|,10,-0.2,0.0685,10,-0.9,0.107,-0.3,0.109,0.791,-5.7,2.9
ENSMUSG00000000094,TBX4,T-box 4,nucleus|,"angiogenesis|morphogenesis of an epithelium|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|lung development|embryonic limb morphogenesis|limb morphogenesis|skeletal system morphogenesis|",DNA binding|sequence-specific DNA binding transcription factor activity|,10,-4.6,1.96,10,0.4,0.249,-1.3,0.109,0.791,-8.9,3.4
ENSMUSG00000070737,GM12942,predicted gene 12942,cellular_component|membrane|integral component of membrane|,biological_process|,molecular_function|,0,0,0,1,-0.9,0.119,-0.9,0.109,0.791,-2,1.8
ENSMUSG00000030225,DERA,deoxyribose-phosphate aldolase (putative),cytoplasm|extracellular vesicular exosome|,deoxyribonucleotide catabolic process|deoxyribonucleoside catabolic process|deoxyribose phosphate catabolic process|,deoxyribose-phosphate aldolase activity|,10,1.3,0.737,10,-0.1,0.0395,0.8,0.109,0.791,-6.1,5.6
ENSMUSG00000026623,LPGAT1,lysophosphatidylglycerol acyltransferase 1,cytoplasm|endoplasmic reticulum membrane|membrane|integral component of membrane|,phospholipid metabolic process|biological_process|phosphatidylglycerol acyl-chain remodeling|small molecule metabolic process|glycerophospholipid biosynthetic process|,"molecular_function|transferase activity, transferring acyl groups|",0,0,0,1,-0.8,0.118,-0.8,0.108,0.792,-2,1.8
ENSMUSG00000053334,FICD,FIC domain containing,integral component of membrane|,protein adenylylation|negative regulation of Rho GTPase activity|,ATP binding|protein adenylyltransferase activity|,10,0,0,10,0.8,0.949,0.6,0.108,0.792,-1.8,3
ENSMUSG00000022479,VDR,"vitamin D (1,25- dihydroxyvitamin D3) receptor",nucleus|nucleoplasm|,"negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|skeletal system development|transcription initiation from RNA polymerase II promoter|calcium ion transport|cellular calcium ion homeostasis|signal transduction|lactation|negative regulation of cell proliferation|organ morphogenesis|gene expression|positive regulation of gene expression|negative regulation of keratinocyte proliferation|positive regulation of vitamin D 24-hydroxylase activity|bile acid signaling pathway|steroid hormone mediated signaling pathway|positive regulation of keratinocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|decidualization|intestinal absorption|positive regulation of apoptotic process involved in mammary gland involution|regulation of calcidiol 1-monooxygenase activity|mammary gland branching involved in pregnancy|vitamin D receptor signaling pathway|",DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|protein binding|zinc ion binding|calcitriol receptor activity|lithocholic acid receptor activity|sequence-specific DNA binding|retinoid X receptor binding|vitamin D response element binding|calcitriol binding|lithocholic acid binding|,9,-0.9,0.178,10,0.2,0.065,0.2,0.108,0.792,-2.9,3.5
ENSMUSG00000035033,TBR1,"T-box, brain, 1",nucleus|,"transcription, DNA-templated|axon guidance|brain development|specification of organ identity|regulation of neuron projection development|hindbrain development|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|,10,-1.4,0.165,10,-0.3,0.205,-0.2,0.108,0.792,-3.4,1.5
ENSMUSG00000036144,MEOX2,mesenchyme homeobox 2,cytoplasm|nuclear speck|,angiogenesis|somite specification|multicellular organismal development|skeletal muscle tissue development|blood circulation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|palate development|limb development|neuron death|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protein binding|sequence-specific DNA binding|,9,-0.1,0.026,10,0.3,0.126,-0.2,0.107,0.792,-7.3,3.4
ENSMUSG00000031603,FGF20,fibroblast growth factor 20,extracellular region|,signal transduction|epidermal growth factor receptor signaling pathway|cell-cell signaling|positive regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of cardiac muscle cell proliferation|inner ear receptor cell differentiation|positive regulation of ERK1 and ERK2 cascade|,fibroblast growth factor receptor binding|growth factor activity|,10,0,0,10,-0.3,0.158,-0.2,0.107,0.792,-7.2,3.5
ENSMUSG00000072605,GM10376,predicted gene 10376,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000079269,GM3676,predicted gene 3676,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000095528,GM10375,predicted gene 10375,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000095384,1700001F09RIK,RIKEN cDNA 1700001F09 gene,None,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000015377,DENND6B,DENN/MADD domain containing 6B,recycling endosome|,positive regulation of Rab GTPase activity|,Rab guanyl-nucleotide exchange factor activity|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000020898,CTC1,CTS telomere maintenance complex component 1,"nuclear chromosome, telomeric region|nucleus|nucleus|Stn1-Ten1 complex|",telomere maintenance|cellular response to DNA damage stimulus|regulation of G2/M transition of mitotic cell cycle|telomere maintenance via telomere lengthening|multicellular organism growth|positive regulation of DNA replication|positive regulation of fibroblast proliferation|spleen development|thymus development|bone marrow development|hematopoietic stem cell proliferation|replicative senescence|,single-stranded DNA binding|protein binding|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000042828,TRIM72,"tripartite motif containing 72, E3 ubiquitin protein ligase",cytoplasmic vesicle membrane|sarcolemma|,plasma membrane repair|muscle system process|exocytosis|muscle organ development|protein homooligomerization|,phosphatidylserine binding|zinc ion binding|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000047281,SFN,stratifin,extracellular space|nucleus|cytoplasm|cytosol|cytoplasmic vesicle membrane|extracellular vesicular exosome|,regulation of cyclin-dependent protein serine/threonine kinase activity|release of cytochrome c from mitochondria|negative regulation of protein kinase activity|apoptotic process|signal transduction|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of epidermal cell division|keratinocyte differentiation|positive regulation of cell growth|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|keratinocyte proliferation|positive regulation of epidermal cell differentiation|positive regulation of protein export from nucleus|membrane organization|establishment of skin barrier|negative regulation of protein serine/threonine kinase activity|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|,protein binding|protein kinase C inhibitor activity|protein kinase binding|protein domain specific binding|phosphoprotein binding|,10,5.1,0.771,10,0,0,0.2,0.105,0.793,-2.9,9.9
ENSMUSG00000091792,GM3573,predicted gene 3573,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000033624,PDPR,pyruvate dehydrogenase phosphatase regulatory subunit,cytoplasm|mitochondrial matrix|,pyruvate metabolic process|glycine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|methylation|cellular metabolic process|small molecule metabolic process|oxidation-reduction process|,aminomethyltransferase activity|oxidoreductase activity|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000035623,RSF1,remodeling and spacing factor 1,nucleus|nucleoplasm|RSF complex|,"nucleosome assembly|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|nucleosome positioning|centromere-specific nucleosome assembly|negative regulation of DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of viral transcription|",protein binding|zinc ion binding|histone binding|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000039456,MORC3,MORC family CW-type zinc finger 3,PML body|,protein phosphorylation|cell aging|post-embryonic development|peptidyl-serine phosphorylation|negative regulation of fibroblast proliferation|protein stabilization|maintenance of protein location in nucleus|maintenance of protein location in nucleus|,ATP binding|zinc ion binding|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000093945,GM3543,predicted gene 3543,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000095226,GM10377,predicted gene 10377,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.8,0.116,-0.8,0.105,0.793,-2,1.8
ENSMUSG00000030341,TNFRSF1A,"tumor necrosis factor receptor superfamily, member 1A",Golgi membrane|extracellular region|extracellular space|nucleus|plasma membrane|integral component of plasma membrane|cell surface|axon|receptor complex|membrane raft|,"response to hypoxia|prostaglandin metabolic process|apoptotic process|inflammatory response|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of gene expression|viral process|cytokine-mediated signaling pathway|response to lipopolysaccharide|negative regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|tetrapyrrole metabolic process|positive regulation of protein import into nucleus, translocation|tumor necrosis factor-mediated signaling pathway|positive regulation of tyrosine phosphorylation of Stat1 protein|defense response to bacterium|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|response to alkaloid|response to ethanol|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of inflammatory response|positive regulation of inflammatory response|protein heterooligomerization|cellular response to mechanical stimulus|cellular response to estradiol stimulus|apoptotic signaling pathway|",protease binding|tumor necrosis factor-activated receptor activity|protein binding|protein complex binding|tumor necrosis factor binding|,10,-1.8,0.841,10,0.4,0.149,0.4,0.105,0.793,-4.1,7.2
ENSMUSG00000021189,ATXN3,ataxin 3,nucleus|nucleoplasm|cytoplasm|cytosol|nuclear matrix|,"microtubule cytoskeleton organization|nucleotide-excision repair|transcription, DNA-templated|regulation of transcription, DNA-templated|misfolded or incompletely synthesized protein catabolic process|synaptic transmission|nervous system development|cell death|regulation of cell-substrate adhesion|actin cytoskeleton organization|monoubiquitinated protein deubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton organization|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to misfolded protein|",ubiquitin thiolesterase activity|ubiquitin-specific protease activity|protein binding|omega peptidase activity|ubiquitin protein ligase binding|ubiquitin protein ligase binding|identical protein binding|ATPase binding|Lys63-specific deubiquitinase activity|Lys48-specific deubiquitinase activity|,10,-0.9,0.697,10,0,0,-0.5,0.104,0.794,-5.4,2.9
ENSMUSG00000055723,RRAS2,related RAS viral (r-ras) oncogene homolog 2,endoplasmic reticulum|plasma membrane|membrane|extracellular vesicular exosome|,osteoblast differentiation|GTP catabolic process|Ras protein signal transduction|positive regulation of cell migration|,GTPase activity|protein binding|GTP binding|,10,0.7,0.241,10,-0.5,0.194,0.3,0.102,0.796,-4.1,4.4
ENSMUSG00000001518,ITFG2,integrin alpha FG-GAP repeat containing 2,None,None,None,0,0,0,1,-0.8,0.11,-0.8,0.1,0.797,-2,1.8
ENSMUSG00000032691,NLRP3,"NLR family, pyrin domain containing 3",cytoplasm|cytoplasm|cytosol|NLRP3 inflammasome complex|,"negative regulation of acute inflammatory response|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|inflammatory response|signal transduction|detection of biotic stimulus|negative regulation of NF-kappaB transcription factor activity|interleukin-1 beta production|interleukin-18 production|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|NLRP3 inflammasome complex assembly|innate immune response|interleukin-1 secretion|negative regulation of interleukin-1 beta secretion|positive regulation of interleukin-1 beta secretion|negative regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|defense response to virus|cellular response to lipopolysaccharide|",protein binding|ATP binding|peptidoglycan binding|,10,0.1,0.0213,10,0.5,0.157,0.3,0.1,0.797,-2.3,4.9
ENSMUSG00000062203,GSPT1,G1 to S phase transition 1,intracellular|,"G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|GTP catabolic process|GTP catabolic process|translational termination|protein methylation|",translation release factor activity|GTPase activity|protein binding|GTP binding|poly(A) RNA binding|,9,-0.5,0.199,10,2.2,0.692,2.1,0.0988,0.798,-2.7,7.5
ENSMUSG00000020074,CCAR1,cell division cycle and apoptosis regulator 1,nucleoplasm|perinuclear region of cytoplasm|,"mRNA splicing, via spliceosome|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cell cycle|RNA splicing|gene expression|",protein binding|ligand-dependent nuclear receptor transcription coactivator activity|poly(A) RNA binding|,10,0,0,10,1.2,0.779,1.2,0.0983,0.798,-5.1,5.8
ENSMUSG00000041565,L3MBTL4,l(3)mbt-like 4 (Drosophila),nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|chromatin modification|",sequence-specific DNA binding transcription factor activity|zinc ion binding|,10,0,0,10,-2.8,1.83,-0.3,0.0974,0.798,-6.7,1.4
ENSMUSG00000019865,NMBR,neuromedin B receptor,cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|,G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|bombesin receptor signaling pathway|,bombesin receptor activity|,9,0.9,0.342,9,0.1,0.0214,0.2,0.0971,0.799,-8.4,6
ENSMUSG00000039193,NLRC4,"NLR family, CARD domain containing 4",intracellular|cytosol|cytosol|IPAF inflammasome complex|,"activation of innate immune response|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|detection of bacterium|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|defense response to bacterium|positive regulation of apoptotic process|innate immune response|interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|protein homooligomerization|pyroptosis|",magnesium ion binding|protein binding|ATP binding|identical protein binding|protein homodimerization activity|,10,0,0,10,-0.4,0.301,-0.2,0.0969,0.799,-4.2,5.4
ENSMUSG00000031370,ZRSR2,"zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2",U12-type spliceosomal complex|,"spliceosomal complex assembly|mRNA splicing, via spliceosome|RNA splicing|",nucleotide binding|protein binding|pre-mRNA 3'-splice site binding|metal ion binding|,10,0.3,0.149,10,0,0,0.3,0.0969,0.799,-5.3,4.3
ENSMUSG00000043131,MOB1A,MOB kinase activator 1A,cytosol|extracellular vesicular exosome|,hippo signaling|hippo signaling|,protein binding|metal ion binding|,10,0,0,10,0.7,0.366,0.3,0.0969,0.799,-4.3,4.2
ENSMUSG00000072115,ANG,"angiogenin, ribonuclease, RNase A family, 5",basal lamina|extracellular space|nucleus|nucleolus|growth cone|angiogenin-PRI complex|neuronal cell body|extracellular vesicular exosome|,"angiogenesis|angiogenesis|angiogenesis|ovarian follicle development|oocyte maturation|response to hypoxia|response to hypoxia|placenta development|positive regulation of endothelial cell proliferation|diacylglycerol biosynthetic process|cell communication|activation of phospholipase C activity|cell death|rRNA transcription|response to hormone|cell migration|negative regulation of translation|actin filament polymerization|activation of protein kinase B activity|activation of phospholipase A2 activity|positive regulation of phosphorylation|homeostatic process|negative regulation of smooth muscle cell proliferation|positive regulation of protein secretion|positive regulation of protein secretion|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|","DNA binding|actin binding|endonuclease activity|ribonuclease activity|receptor binding|copper ion binding|protein binding|heparin binding|endoribonuclease activity, producing 3'-phosphomonoesters|rRNA binding|peptide binding|",10,0.3,0.0705,10,0.2,0.0365,0.2,0.0957,0.8,-1.5,2.6
ENSMUSG00000074340,OVGP1,"oviductal glycoprotein 1, 120kDa",cytosol|transport vesicle|,carbohydrate metabolic process|chitin catabolic process|single fertilization|binding of sperm to zona pellucida|female pregnancy|multicellular organism reproduction|,chitinase activity|,10,0.1,0.021,10,0.4,0.106,0.2,0.0957,0.8,-3.2,3.2
ENSMUSG00000037876,JMJD1C,jumonji domain containing 1C,intracellular|nucleoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|blood coagulation|chromatin modification|oxidation-reduction process|",protein binding|metal ion binding|thyroid hormone receptor binding|dioxygenase activity|,0,0,0,1,-0.8,0.105,-0.8,0.0956,0.8,-2,1.8
ENSMUSG00000032315,CYP1A1,"cytochrome P450, family 1, subfamily A, polypeptide 1",mitochondrion|endoplasmic reticulum membrane|,response to hypoxia|porphyrin-containing compound metabolic process|xenobiotic metabolic process|aging|cell proliferation|amine metabolic process|response to wounding|response to virus|response to nematode|response to herbicide|embryo development ending in birth or egg hatching|coumarin metabolic process|flavonoid metabolic process|response to iron(III) ion|insecticide metabolic process|drug metabolic process|dibenzo-p-dioxin catabolic process|arachidonic acid metabolic process|epoxygenase P450 pathway|response to food|response to lipopolysaccharide|response to vitamin A|vitamin D metabolic process|response to drug|9-cis-retinoic acid biosynthetic process|camera-type eye development|cellular lipid metabolic process|small molecule metabolic process|response to antibiotic|response to arsenic-containing substance|digestive tract development|hydrogen peroxide biosynthetic process|response to hyperoxia|oxidation-reduction process|maternal process involved in parturition|hepatocyte differentiation|demethylation|cellular response to organic cyclic compound|omega-hydroxylase P450 pathway|positive regulation of G1/S transition of mitotic cell cycle|,"iron ion binding|steroid hydroxylase activity|oxidoreductase activity|oxidoreductase activity, acting on diphenols and related substances as donors|flavonoid 3'-monooxygenase activity|oxygen binding|enzyme binding|heme binding|demethylase activity|aromatase activity|vitamin D 24-hydroxylase activity|",10,-1.9,0.468,10,-0.1,0.0118,0.8,0.0951,0.8,-6.4,4.8
ENSMUSG00000005204,SENP3,SUMO1/sentrin/SMT3 specific peptidase 3,nucleolus|cytoplasm|MLL1 complex|,proteolysis|,ubiquitin-specific protease activity|protein binding|,0,0,0,1,-0.8,0.104,-0.8,0.095,0.8,-2,1.8
ENSMUSG00000078923,UBE2V1,ubiquitin-conjugating enzyme E2 variant 1,ubiquitin ligase complex|nucleus|cytoplasm|cytosol|ubiquitin conjugating enzyme complex|UBC13-UEV1A complex|protein complex|extracellular vesicular exosome|,"protein polyubiquitination|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|regulation of DNA repair|regulation of transcription, DNA-templated|cell differentiation|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|protein K63-linked ubiquitination|",protein binding|acid-amino acid ligase activity|,0,0,0,1,-0.8,0.104,-0.8,0.0946,0.8,-2,1.8
ENSMUSG00000024598,FBN2,fibrillin 2,microfibril|extracellular region|proteinaceous extracellular matrix|,anatomical structure morphogenesis|extracellular matrix disassembly|extracellular matrix organization|embryonic limb morphogenesis|positive regulation of bone mineralization|sequestering of TGFbeta in extracellular matrix|positive regulation of osteoblast differentiation|bone trabecula formation|,extracellular matrix structural constituent|calcium ion binding|,10,0,0,10,0.7,0.651,0.3,0.0928,0.802,-1.6,2.5
ENSMUSG00000030699,TBX6,T-box 6,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|mesoderm formation|cell fate specification|transcription, DNA-templated|mesoderm development|anatomical structure morphogenesis|signal transduction involved in regulation of gene expression|",RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|,10,-1.5,0.216,10,0.9,0.169,0.3,0.0926,0.802,-6.6,7.5
ENSMUSG00000026349,CCNT2,cyclin T2,nucleus|nucleoplasm|,"regulation of cyclin-dependent protein serine/threonine kinase activity|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|cell cycle|transforming growth factor beta receptor signaling pathway|gene expression|viral process|positive regulation of transcription from RNA polymerase II promoter|cell division|",protein kinase binding|,10,-0.4,0.0894,10,-0.2,0.0259,-0.3,0.0913,0.803,-7.4,2.9
ENSMUSG00000063015,CCNI,cyclin I,None,spermatogenesis|regulation of cell cycle|,None,10,-1,0.749,10,0.5,0.048,-0.6,0.0907,0.803,-5,2.8
ENSMUSG00000042599,JHDM1D,N/A,None,None,None,0,0,0,1,-0.7,0.0988,-0.7,0.09,0.803,-2,1.8
ENSMUSG00000013483,CARD14,"caspase recruitment domain family, member 14",cytoplasm|plasma membrane|,positive regulation of protein phosphorylation|apoptotic process|activation of NF-kappaB-inducing kinase activity|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|positive regulation of NF-kappaB transcription factor activity|,CARD domain binding|,10,-0.8,0.246,10,0.9,0.977,0.5,0.0893,0.804,-2.8,3.5
ENSMUSG00000090639,GM20425,N/A,None,None,None,8,4.6,1.1,8,0,0,-0.3,0.0893,0.804,-5.9,10
ENSMUSG00000094733,GM5416,predicted gene 5416,cellular_component|,biological_process|,molecular_function|,1,-0.2,0.0119,1,-1.3,0.241,-1.1,0.0883,0.804,-2,1.8
ENSMUSG00000049436,UPK1B,uroplakin 1B,integral component of membrane|apical plasma membrane|extracellular vesicular exosome|,epithelial cell differentiation|,structural molecule activity|,10,-0.6,0.0896,10,-0.2,0.0277,-0.4,0.088,0.804,-5.9,2.6
ENSMUSG00000047861,FOXI1,forkhead box I1,nucleus|,"transcription, DNA-templated|embryo development|inner ear morphogenesis|positive regulation of transcription from RNA polymerase II promoter|","sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding|transcription regulatory region DNA binding|",10,-2,1.32,10,0,0,-1.4,0.0873,0.805,-4.3,2.8
ENSMUSG00000027164,TRAF6,"TNF receptor-associated factor 6, E3 ubiquitin protein ligase",nucleus|nucleolus|cytoplasm|mitochondrion|lipid particle|cytosol|plasma membrane|plasma membrane|cell cortex|cytoplasmic side of plasma membrane|endosome membrane|CD40 receptor complex|protein complex|perinuclear region of cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|protein polyubiquitination|ossification|neural tube closure|toll-like receptor signaling pathway|positive regulation of T cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein complex assembly|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|JNK cascade|antigen processing and presentation of exogenous peptide antigen via MHC class II|osteoclast differentiation|membrane protein intracellular domain proteolysis|positive regulation of protein ubiquitination|positive regulation of lipopolysaccharide-mediated signaling pathway|activation of protein kinase activity|positive regulation of interleukin-2 production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|T-helper 1 type immune response|positive regulation of T cell proliferation|odontogenesis of dentin-containing tooth|myeloid dendritic cell differentiation|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JUN kinase activity|positive regulation of JUN kinase activity|positive regulation of interleukin-12 biosynthetic process|innate immune response|positive regulation of interleukin-6 biosynthetic process|bone resorption|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|cell development|positive regulation of smooth muscle cell proliferation|T cell receptor signaling pathway|T cell receptor signaling pathway|positive regulation of T cell activation|regulation of immunoglobulin secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|protein autoubiquitination|protein autoubiquitination|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|protein K63-linked ubiquitination|response to interleukin-1|cellular response to lipopolysaccharide|apoptotic signaling pathway|positive regulation of transcription regulatory region DNA binding|",ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|signal transducer activity|tumor necrosis factor receptor binding|protein binding|zinc ion binding|ligase activity|protein kinase binding|mitogen-activated protein kinase kinase kinase binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|thioesterase binding|histone deacetylase binding|protein kinase B binding|protein N-terminus binding|,10,0.5,0.146,10,0.1,0.0145,0.2,0.0872,0.805,-2.8,2.8
ENSMUSG00000090084,SRPX,"sushi-repeat containing protein, X-linked",autophagic vacuole|endoplasmic reticulum|cell surface|membrane|,phagolysosome assembly|autophagy|cell adhesion|response to endoplasmic reticulum stress|negative regulation of cell proliferation involved in contact inhibition|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|,None,10,0,0,10,0.6,0.659,0.2,0.087,0.805,-3.5,3.6
ENSMUSG00000037847,NMRK1,nicotinamide riboside kinase 1,None,NAD biosynthetic process|phosphorylation|,ATP binding|metal ion binding|ribosylnicotinamide kinase activity|,10,-0.9,0.241,10,0.2,0.0266,-0.4,0.0869,0.805,-4,2.8
ENSMUSG00000029128,RAB28,"RAB28, member RAS oncogene family",cytoplasm|plasma membrane|ciliary rootlet|ciliary basal body|,GTP catabolic process|small GTPase mediated signal transduction|,GTPase activity|GTP binding|GDP binding|,0,0,0,1,0.5,0.0943,0.5,0.0859,0.806,-1.8,2
ENSMUSG00000019851,PERP,"PERP, TP53 apoptosis effector",mitochondrion|Golgi apparatus|integral component of plasma membrane|desmosome|,desmosome organization|heterotypic cell-cell adhesion|positive regulation of proteolysis|intrinsic apoptotic signaling pathway by p53 class mediator|amelogenesis|activation of cysteine-type endopeptidase activity|,None,0,0,0,1,0.5,0.0943,0.5,0.0859,0.806,-1.8,2
ENSMUSG00000020780,SRP68,signal recognition particle 68kDa,"nucleolus|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|ribosome|",translation|SRP-dependent cotranslational protein targeting to membrane|gene expression|response to drug|cellular protein metabolic process|,signal recognition particle binding|7S RNA binding|endoplasmic reticulum signal peptide binding|poly(A) RNA binding|,0,0,0,1,0.5,0.0943,0.5,0.0859,0.806,-1.8,2
ENSMUSG00000090425,EFNA5,ephrin-A5,plasma membrane|caveola|anchored component of external side of plasma membrane|,nervous system development|axon guidance|regulation of cell-cell adhesion|retinal ganglion cell axon guidance|regulation of Rac GTPase activity|regulation of Rho GTPase activity|regulation of actin cytoskeleton organization|ephrin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|regulation of focal adhesion assembly|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of microtubule cytoskeleton organization|,chemorepellent activity|ephrin receptor binding|,0,0,0,1,0.5,0.0943,0.5,0.0859,0.806,-1.8,2
ENSMUSG00000021947,CRYL1,"crystallin, lambda 1",cytosol|extracellular vesicular exosome|,fatty acid metabolic process|oxidation-reduction process|,3-hydroxyacyl-CoA dehydrogenase activity|protein homodimerization activity|L-gulonate 3-dehydrogenase activity|NAD+ binding|,10,-4.2,0.997,10,-0.2,0.071,-0.3,0.0855,0.806,-7.9,2.4
ENSMUSG00000018654,IKZF1,IKAROS family zinc finger 1 (Ikaros),nucleus|centromeric heterochromatin|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|natural killer cell differentiation|transcription, DNA-templated|cell cycle|mesoderm development|chromatin modification|B cell differentiation|T cell differentiation|forebrain development|positive regulation of multicellular organism growth|positive regulation of neutrophil differentiation|positive regulation of transcription from RNA polymerase II promoter|lymph node development|thymus development|Peyer's patch development|gland development|positive regulation of NK T cell differentiation|retina development in camera-type eye|",DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|metal ion binding|protein heterodimerization activity|,9,0.2,0.0314,8,0.3,0.069,0.3,0.0851,0.806,-2.6,3.9
ENSMUSG00000078919,DPM1,"dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit",nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum membrane|membrane|dolichol-phosphate-mannose synthase complex|,dolichol-linked oligosaccharide biosynthetic process|C-terminal protein lipidation|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|dolichol metabolic process|GDP-mannose metabolic process|protein mannosylation|protein O-linked mannosylation|post-translational protein modification|cellular protein metabolic process|,dolichyl-phosphate-mannose-protein mannosyltransferase activity|dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|mannose binding|alcohol binding|,0,0,0,1,-0.7,0.093,-0.7,0.0848,0.806,-2,1.8
ENSMUSG00000005674,TOMM40L,translocase of outer mitochondrial membrane 40 homolog (yeast)-like,mitochondrial outer membrane|protein complex|pore complex|,ion transport|biological_process|protein transport|transmembrane transport|,molecular_function|porin activity|,0,0,0,1,-0.7,0.093,-0.7,0.0848,0.806,-2,1.8
ENSMUSG00000093752,GM20716,N/A,None,None,None,0,0,0,1,-0.7,0.093,-0.7,0.0848,0.806,-2,1.8
ENSMUSG00000020150,GAMT,guanidinoacetate N-methyltransferase,cytosol|extracellular vesicular exosome|,creatine metabolic process|creatine biosynthetic process|creatine biosynthetic process|muscle contraction|spermatogenesis|organ morphogenesis|methylation|cellular nitrogen compound metabolic process|regulation of multicellular organism growth|small molecule metabolic process|,methyltransferase activity|guanidinoacetate N-methyltransferase activity|,10,-0.8,0.417,10,0,0,-0.4,0.0845,0.806,-2.7,1.4
ENSMUSG00000022013,DNAJC15,"DnaJ (Hsp40) homolog, subfamily C, member 15",mitochondrial inner membrane|integral component of membrane|,protein transport|,None,9,-0.1,0.0109,10,-1,0.529,-0.7,0.0843,0.807,-6,2.6
ENSMUSG00000055022,CNTN1,contactin 1,plasma membrane|membrane|anchored component of membrane|extracellular vesicular exosome|,cell adhesion|Notch signaling pathway|axon guidance|positive regulation of gene expression|positive regulation of sodium ion transport|positive regulation of neuron projection development|cerebellum development|,glycoprotein binding|carbohydrate binding|,10,-0.4,0.117,10,-1.7,0.495,-0.3,0.084,0.807,-6.6,3.4
ENSMUSG00000052534,PBX1,pre-B-cell leukemia homeobox 1,nucleus|transcription factor complex|cytoplasm|,"branching involved in ureteric bud morphogenesis|transcription, DNA-templated|steroid biosynthetic process|sex differentiation|positive regulation of cell proliferation|organ morphogenesis|anterior/posterior pattern specification|proximal/distal pattern formation|positive regulation of G2/M transition of mitotic cell cycle|regulation of ossification|adrenal gland development|embryonic limb morphogenesis|embryonic hemopoiesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|spleen development|thymus development|embryonic skeletal system development|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|sequence-specific DNA binding|protein heterodimerization activity|,9,0.9,0.538,10,-0.7,0.57,-0.3,0.0828,0.808,-3.5,3.7
ENSMUSG00000089682,BCL2L2,BCL2-like 2,mitochondrial outer membrane|cytosol|extracellular vesicular exosome|,spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of apoptotic process|Sertoli cell proliferation|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein binding|protein homodimerization activity|protein heterodimerization activity|BH domain binding|,10,0.5,0.385,10,-0.3,0.141,-0.3,0.082,0.808,-3,2.4
ENSMUSG00000002249,TEAD3,TEA domain family member 3,nucleoplasm|transcription factor complex|,regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|female pregnancy|gene expression|hippo signaling|positive regulation of transcription from RNA polymerase II promoter|,RNA polymerase II transcription factor binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,-0.7,0.764,9,0.7,0.362,-0.2,0.0815,0.809,-5.7,3
ENSMUSG00000036658,OLFR11,olfactory receptor 11,plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|response to stimulus|detection of chemical stimulus involved in sensory perception of smell|,signal transducer activity|G-protein coupled receptor activity|olfactory receptor activity|,0,0,0,1,-0.7,0.0892,-0.7,0.0813,0.809,-2,1.8
ENSMUSG00000031787,KATNB1,katanin p80 (WD repeat containing) subunit B 1,spindle pole|nucleus|cytoplasm|centrosome|microtubule|katanin complex|katanin complex|membrane|axon|growth cone|midbody|neuronal cell body|,ATP catabolic process|protein targeting|negative regulation of microtubule depolymerization|mitotic chromosome movement towards spindle pole|positive regulation of cell death|positive regulation of neuron projection development|positive regulation of microtubule depolymerization|microtubule severing|,microtubule binding|microtubule-severing ATPase activity|dynein binding|protein heterodimerization activity|,10,-0.3,0.245,10,0,0,-0.2,0.0811,0.809,-2.4,1.7
ENSMUSG00000032065,TEX12,testis expressed 12,synaptonemal complex|,None,None,0,0,0,1,-0.7,0.0883,-0.7,0.0805,0.809,-2,1.8
ENSMUSG00000025574,TK1,"thymidine kinase 1, soluble",cytosol|,liver development|nucleobase-containing compound metabolic process|pyrimidine nucleobase metabolic process|DNA replication|deoxyribonucleoside monophosphate biosynthetic process|deoxyribonucleoside monophosphate biosynthetic process|nucleotide biosynthetic process|response to toxic substance|skeletal muscle cell proliferation|phosphorylation|response to nutrient levels|pyrimidine nucleoside salvage|small molecule metabolic process|thymidine metabolic process|response to copper ion|digestive tract development|protein homotetramerization|response to cortisol|nucleobase-containing small molecule metabolic process|fetal process involved in parturition|,thymidine kinase activity|ATP binding|zinc ion binding|nucleoside kinase activity|identical protein binding|,10,-0.7,0.409,10,0,0,-0.3,0.0803,0.809,-10.4,2
ENSMUSG00000022243,SLC45A2,"solute carrier family 45, member 2",integral component of membrane|melanosome membrane|,visual perception|melanin biosynthetic process|developmental pigmentation|response to stimulus|,None,10,0,0,10,-1,0.34,-0.3,0.0801,0.809,-4.4,5.2
ENSMUSG00000078789,DPH1,diphthamide biosynthesis 1,nucleus|cytoplasm|,translation|cell proliferation|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|,None,10,-0.2,0.0778,10,-0.2,0.0101,-0.2,0.08,0.81,-3.6,3.5
ENSMUSG00000030717,NUPR1,"nuclear protein, transcriptional regulator, 1",nucleus|cytoplasm|,"acute inflammatory response|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|protein acetylation|male gonad development|response to toxic substance|cell growth|positive regulation of protein modification process|skeletal muscle cell differentiation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|negative regulation of cell cycle|negative regulation of fibroblast proliferation|regulation of female gonad development|",molecular_function|DNA binding|chromatin binding|,10,3.8,0.292,10,-0.3,0.0936,-0.2,0.0799,0.81,-3.8,7.6
ENSMUSG00000018822,SFRP5,secreted frizzled-related protein 5,extracellular space|cytoplasm|plasma membrane|,vasculature development|apoptotic process|establishment or maintenance of cell polarity|signal transduction|brain development|visual perception|negative regulation of cell proliferation|gonad development|anatomical structure morphogenesis|cell differentiation|negative regulation of catenin import into nucleus|post-anal tail morphogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of JUN kinase activity|digestive tract morphogenesis|negative regulation of protein kinase B signaling|convergent extension involved in axis elongation|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|negative regulation of planar cell polarity pathway involved in axis elongation|negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis|,Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|,10,-0.6,0.138,10,0.5,0.327,-0.4,0.0798,0.81,-4.5,2.6
ENSMUSG00000021702,THBS4,thrombospondin 4,extracellular region|basement membrane|extracellular space|endoplasmic reticulum|sarcoplasmic reticulum|extracellular matrix|,positive regulation of endothelial cell proliferation|response to unfolded protein|negative regulation of angiogenesis|regulation of tissue remodeling|response to endoplasmic reticulum stress|behavioral response to pain|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|myoblast migration|positive regulation of cell division|endothelial cell-cell adhesion|positive regulation of neutrophil chemotaxis|,integrin binding|calcium ion binding|protein binding|growth factor activity|heparin binding|,10,-3.5,2.55,10,0.4,0.0358,-0.3,0.0796,0.81,-8.7,2.4
ENSMUSG00000060445,SYCP2,synaptonemal complex protein 2,synaptonemal complex|lateral element|nucleus|,meiotic prophase I|synaptonemal complex assembly|male meiosis|female meiotic division|fertilization|negative regulation of apoptotic process|male genitalia morphogenesis|,DNA binding|protein heterodimerization activity|,10,0.1,0.00244,10,0.7,0.194,0.2,0.0792,0.81,-3.3,3.9
ENSMUSG00000031227,MAGEE1,"melanoma antigen family E, 1",nucleus|plasma membrane|dystrophin-associated glycoprotein complex|dendrite|postsynaptic membrane|perinuclear region of cytoplasm|,biological_process|,protein binding|,10,0.2,0.0604,10,0.2,0.0256,0.2,0.0782,0.811,-1.9,2.9
ENSMUSG00000068129,CST7,cystatin F (leukocystatin),extracellular region|cytoplasm|,immune response|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|,endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|,10,-0.9,1.04,10,0,0,-0.4,0.0773,0.812,-3,1.7
ENSMUSG00000054843,ATRNL1,attractin-like 1,integral component of membrane|,G-protein coupled receptor signaling pathway|multicellular organismal development|,receptor activity|carbohydrate binding|,10,3.4,0.0464,10,-0.7,0.42,-0.2,0.077,0.812,-7,7.5
ENSMUSG00000019997,CTGF,connective tissue growth factor,extracellular region|proteinaceous extracellular matrix|extracellular space|Golgi apparatus|cis-Golgi network|cytosol|plasma membrane|cell cortex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|,cartilage condensation|ossification|angiogenesis|regulation of cell growth|positive regulation of protein phosphorylation|DNA replication|transcription initiation from RNA polymerase II promoter|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|epidermis development|response to wounding|response to glucose|organ senescence|gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|cell migration|cell differentiation|lung development|regulation of chondrocyte differentiation|response to estradiol|positive regulation of collagen biosynthetic process|response to anoxia|intracellular signal transduction|chondrocyte proliferation|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to peptide hormone|cellular lipid metabolic process|small molecule metabolic process|positive regulation of cell differentiation|positive regulation of JNK cascade|positive regulation of cell activation|response to mineralocorticoid|positive regulation of stress fiber assembly|cytosolic calcium ion transport|positive regulation of cardiac muscle contraction|negative regulation of cell death|extracellular matrix constituent secretion|positive regulation of G0 to G1 transition|positive regulation of ERK1 and ERK2 cascade|response to fatty acid|reactive oxygen species metabolic process|,fibronectin binding|integrin binding|protein binding|insulin-like growth factor binding|growth factor activity|heparin binding|,10,1.5,2.01,10,0,0,1.1,0.077,0.812,-2.5,5.3
ENSMUSG00000045948,MRPS12,mitochondrial ribosomal protein S12,mitochondrial ribosome|small ribosomal subunit|,translation|,structural constituent of ribosome|protein binding|poly(A) RNA binding|,10,1,0.963,10,0,0,0.4,0.0762,0.812,-2.9,4
ENSMUSG00000024515,SMAD4,SMAD family member 4,nuclear chromatin|nucleus|nucleoplasm|transcription factor complex|transcription factor complex|cytoplasm|centrosome|cytosol|activin responsive factor complex|SMAD protein complex|,"negative regulation of transcription from RNA polymerase II promoter|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|gastrulation with mouth forming second|atrioventricular valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of cell proliferation involved in heart valve morphogenesis|cardiac septum development|brainstem development|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|axon guidance|endoderm development|mesoderm development|cell proliferation|negative regulation of cell proliferation|gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell differentiation|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of cell growth|BMP signaling pathway|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|somite rostral/caudal axis specification|regulation of transforming growth factor beta2 production|intracellular signal transduction|atrioventricular canal development|endothelial cell activation|negative regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|developmental growth|neuron fate commitment|sebaceous gland development|formation of anatomical boundary|regulation of binding|regulation of hair follicle development|palate development|positive regulation of SMAD protein import into nucleus|SMAD protein signal transduction|negative regulation of cell death|endocardial cell differentiation|response to transforming growth factor beta|metanephric mesenchyme morphogenesis|nephrogenic mesenchyme morphogenesis|","core promoter proximal region sequence-specific DNA binding|protein binding transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II transcription factor binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|collagen binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity|identical protein binding|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding|I-SMAD binding|R-SMAD binding|",10,-0.3,0.0478,10,-0.6,0.0796,-0.4,0.0758,0.812,-5.7,2
ENSMUSG00000014030,PAX5,paired box 5,nucleus|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|humoral immune response|multicellular organismal development|spermatogenesis|nervous system development|organ morphogenesis|skeletal muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|negative regulation of histone H3-K9 methylation|,DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,0.5,0.48,10,0,0,0.2,0.0756,0.813,-2,2.8
ENSMUSG00000039323,IGFBP2,"insulin-like growth factor binding protein 2, 36kDa",extracellular region|extracellular region|extracellular space|apical plasma membrane|cytoplasmic vesicle|extracellular vesicular exosome|,regulation of cell growth|signal transduction|female pregnancy|aging|response to nutrient|response to mechanical stimulus|response to lithium ion|response to estradiol|response to retinoic acid|cellular response to hormone stimulus|positive regulation of activated T cell proliferation|response to drug|regulation of insulin-like growth factor receptor signaling pathway|regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|response to glucocorticoid|,protein binding|insulin-like growth factor I binding|insulin-like growth factor II binding|,10,-0.1,0.00823,10,-0.3,0.085,-0.2,0.0755,0.813,-3.1,1.7
ENSMUSG00000021219,RGS6,regulator of G-protein signaling 6,cytoplasm|heterotrimeric G-protein complex|plasma membrane|,G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|intracellular signal transduction|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|positive regulation of GTPase activity|positive regulation of neuron differentiation|,signal transducer activity|GTPase activator activity|protein binding|,10,-0.3,0.151,10,0.6,0.405,-0.2,0.0749,0.813,-3.5,2.8
ENSMUSG00000095498,IFNA1,"interferon, alpha 1",None,None,None,0,0,0,1,-0.6,0.0822,-0.6,0.0749,0.813,-2,1.8
ENSMUSG00000069769,MSI2,musashi RNA-binding protein 2,cytoplasm|polysome|,stem cell development|,nucleotide binding|poly(U) RNA binding|poly(A) RNA binding|,10,0.1,0.024,10,0.4,0.0946,0.2,0.0746,0.813,-2.8,4.2
ENSMUSG00000029436,MMP17,matrix metallopeptidase 17 (membrane-inserted),proteinaceous extracellular matrix|integral component of plasma membrane|anchored component of membrane|,proteolysis|positive regulation of catalytic activity|,metalloendopeptidase activity|calcium ion binding|enzyme activator activity|zinc ion binding|,9,-0.5,0.314,10,0,0,-0.2,0.0737,0.814,-9.3,3.5
ENSMUSG00000000957,MMP14,matrix metallopeptidase 14 (membrane-inserted),cytoplasm|Golgi lumen|plasma membrane|integral component of plasma membrane|extracellular matrix|melanosome|,"ossification|angiogenesis|ovarian follicle development|response to hypoxia|endothelial cell proliferation|regulation of transcription, DNA-templated|proteolysis|response to oxidative stress|male gonad development|response to mechanical stimulus|positive regulation of peptidase activity|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell growth|lung development|positive regulation of cell migration|collagen catabolic process|zymogen activation|astrocyte cell migration|response to estrogen|branching morphogenesis of an epithelial tube|tissue remodeling|negative regulation of focal adhesion assembly|",sequence-specific DNA binding transcription factor activity|metalloendopeptidase activity|integrin binding|calcium ion binding|protein binding|zinc ion binding|peptidase activator activity|,10,-1.1,0.7,10,0.3,0.084,-0.6,0.0737,0.814,-4.6,3.1
ENSMUSG00000026840,LAMC3,"laminin, gamma 3",extracellular region|proteinaceous extracellular matrix|basement membrane|membrane|,cell morphogenesis involved in differentiation|cell adhesion|visual perception|astrocyte development|extracellular matrix organization|retina development in camera-type eye|,structural molecule activity|,10,-1.4,0.855,10,0,0,-0.7,0.0732,0.815,-3.9,2.2
ENSMUSG00000067370,B3GALT4,"UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4",Golgi membrane|integral component of membrane|,protein glycosylation|,"UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|ganglioside galactosyltransferase activity|",10,-0.2,0.0537,10,-0.2,0.0266,-0.2,0.0731,0.815,-3.6,2.8
ENSMUSG00000022948,SETD4,SET domain containing 4,None,methylation|,methyltransferase activity|,0,0,0,1,-0.6,0.0801,-0.6,0.073,0.815,-2,1.8
ENSMUSG00000034575,PAPD7,PAP associated domain containing 7,nucleus|nucleoplasm|cytoplasm|,DNA-dependent DNA replication|double-strand break repair|sister chromatid cohesion|mitotic chromosome condensation|response to drug|,DNA binding|DNA-directed DNA polymerase activity|polynucleotide adenylyltransferase activity|SMC family protein binding|metal ion binding|,10,-5.3,1.44,10,0,0,-0.2,0.0726,0.815,-10.3,3.1
ENSMUSG00000021572,CEP72,centrosomal protein 72kDa,centrosome|cytosol|,G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle organization|gamma-tubulin complex localization|,protein binding|identical protein binding|,10,0,0,10,-0.5,0.249,-0.2,0.072,0.816,-4.5,2.5
ENSMUSG00000025499,HRAS,Harvey rat sarcoma viral oncogene homolog,Golgi membrane|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|plasma membrane|perinuclear region of cytoplasm|,"MAPK cascade|activation of MAPKK activity|positive regulation of protein phosphorylation|GTP catabolic process|endocytosis|chemotaxis|cell cycle arrest|cell cycle arrest|mitotic cell cycle checkpoint|signal transduction|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|small GTPase mediated signal transduction|Ras protein signal transduction|Ras protein signal transduction|synaptic transmission|axon guidance|blood coagulation|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|insulin receptor signaling pathway|visual learning|fibroblast growth factor receptor signaling pathway|organ morphogenesis|negative regulation of gene expression|actin cytoskeleton organization|positive regulation of cell migration|regulation of synaptic transmission, GABAergic|positive regulation of Rac GTPase activity|negative regulation of Rho GTPase activity|positive regulation of Rac protein signal transduction|social behavior|Fc-epsilon receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|innate immune response|positive regulation of DNA replication|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|neurotrophin TRK receptor signaling pathway|regulation of long-term neuronal synaptic plasticity|positive regulation of epithelial cell proliferation|leukocyte migration|striated muscle cell differentiation|protein heterooligomerization|positive regulation of ERK1 and ERK2 cascade|positive regulation of wound healing|cellular senescence|intrinsic apoptotic signaling pathway|positive regulation of ruffle assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of miRNA metabolic process|",protein binding|GTP binding|protein C-terminus binding|,10,-2.3,0.843,10,0,0,-0.4,0.0719,0.816,-4.5,1.9
ENSMUSG00000022894,ADAMTS5,"ADAM metallopeptidase with thrombospondin type 1 motif, 5",extracellular region|proteinaceous extracellular matrix|,proteolysis|extracellular matrix disassembly|extracellular matrix organization|,metalloendopeptidase activity|integrin binding|protein binding|metallopeptidase activity|zinc ion binding|,10,0,0,10,0.9,0.86,0.3,0.0718,0.816,-2.9,3
ENSMUSG00000033191,TIE1,tyrosine kinase with immunoglobulin-like and EGF-like domains 1,integral component of plasma membrane|,angiogenesis|vasculogenesis|in utero embryonic development|signal transduction|mesoderm development|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|negative regulation of cell migration|response to retinoic acid|plasma membrane fusion|,transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|,10,-0.4,0.0897,10,0.8,0.705,0.2,0.0713,0.816,-3.6,8.8
ENSMUSG00000027242,WDR76,WD repeat domain 76,None,None,None,10,-0.9,0.395,10,0.5,0.334,0.3,0.071,0.816,-4.3,3.4
ENSMUSG00000020647,NCOA1,nuclear receptor coactivator 1,nuclear chromatin|nucleoplasm|cytoplasm|neuron projection|,"positive regulation of transcription from RNA polymerase II promoter by galactose|transcription, DNA-templated|lactation|male gonad development|cerebellum development|hippocampus development|hypothalamus development|cerebral cortex development|androgen receptor signaling pathway|response to estradiol|response to retinoic acid|response to progesterone|cellular response to hormone stimulus|positive regulation of apoptotic process|histone H4 acetylation|cellular lipid metabolic process|small molecule metabolic process|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|male mating behavior|estrous cycle phase|labyrinthine layer morphogenesis|regulation of cellular response to drug|",RNA polymerase II regulatory region DNA binding|RNA polymerase II transcription coactivator activity|chromatin binding|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|signal transducer activity|protein binding|ligand-dependent nuclear receptor binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|protein complex binding|progesterone receptor binding|nuclear hormone receptor binding|retinoid X receptor binding|protein dimerization activity|protein N-terminus binding|androgen receptor binding|,10,-0.5,0.228,10,0.5,0.367,-0.3,0.0709,0.816,-4.3,3.5
ENSMUSG00000025860,XIAP,X-linked inhibitor of apoptosis,nucleus|cytoplasm|cytosol|,apoptotic process|cellular response to DNA damage stimulus|Wnt signaling pathway|protein ubiquitination|regulation of BMP signaling pathway|positive regulation of protein ubiquitination|regulation of cell proliferation|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of innate immune response|regulation of inflammatory response|copper ion homeostasis|regulation of nucleotide-binding oligomerization domain containing signaling pathway|positive regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of protein linear polyubiquitination|,ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|,10,0,0,10,-0.5,0.161,-0.4,0.0708,0.816,-4.1,2.9
ENSMUSG00000060177,KLK1B22,kallikrein 1-related peptidase b22,nucleus|,proteolysis|zymogen activation|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,-5.6,2.54,10,-0.6,0.279,-0.2,0.0707,0.816,-11.2,2.2
ENSMUSG00000022146,OSMR,oncostatin M receptor,oncostatin-M receptor complex|,positive regulation of acute inflammatory response|cell surface receptor signaling pathway|cell proliferation|positive regulation of cell proliferation|response to cytokine|oncostatin-M-mediated signaling pathway|oncostatin-M-mediated signaling pathway|,oncostatin-M receptor activity|growth factor binding|,10,-0.6,0.214,10,0.8,0.89,0.2,0.0702,0.817,-3.9,3.9
ENSMUSG00000036777,ANLN,"anillin, actin binding protein",nucleus|actomyosin contractile ring|actin cytoskeleton|intracellular membrane-bounded organelle|,mitotic cytokinesis|septin ring assembly|mitotic nuclear division|regulation of exit from mitosis|,actin binding|,10,-1.8,0.12,10,-0.5,0.105,-0.4,0.0688,0.818,-8,1.9
ENSMUSG00000032846,ZSWIM6,"zinc finger, SWIM-type containing 6",None,neuron projection morphogenesis|regulation of neuron migration|,zinc ion binding|,0,0,0,1,0.4,0.0752,0.4,0.0685,0.818,-1.8,2
ENSMUSG00000024112,CACNA1H,"calcium channel, voltage-dependent, T type, alpha 1H subunit",plasma membrane|voltage-gated calcium channel complex|caveola|integral component of membrane|sarcolemma|,transport|muscle contraction|axon guidance|muscle organ development|myoblast fusion|regulation of heart contraction|aldosterone biosynthetic process|cellular response to hormone stimulus|cortisol biosynthetic process|regulation of ion transmembrane transport|cellular response to potassium ion|regulation of membrane potential|calcium ion import|membrane depolarization during action potential|positive regulation of acrosome reaction|,low voltage-gated calcium channel activity|metal ion binding|scaffold protein binding|,9,-5.8,0.409,10,-1,0.867,-0.3,0.067,0.819,-10.5,3.4
ENSMUSG00000026496,PARP1,poly (ADP-ribose) polymerase 1,nucleus|nuclear envelope|nucleoplasm|transcription factor complex|nucleolus|membrane|,"negative regulation of transcription from RNA polymerase II promoter|telomere maintenance|DNA repair|base-excision repair|double-strand break repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|protein ADP-ribosylation|transforming growth factor beta receptor signaling pathway|gene expression|protein autoprocessing|signal transduction involved in regulation of gene expression|macrophage differentiation|cellular response to insulin stimulus|regulation of growth rate|DNA damage response, detection of DNA damage|positive regulation of transcription from RNA polymerase II promoter|positive regulation of SMAD protein import into nucleus|protein poly-ADP-ribosylation|positive regulation of transcription regulatory region DNA binding|",DNA binding|NAD+ ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|protein binding|transcription factor binding|zinc ion binding|enzyme binding|identical protein binding|poly(A) RNA binding|protein N-terminus binding|NAD binding|R-SMAD binding|,10,-0.7,0.656,10,0,0,-0.2,0.067,0.819,-7.3,2
ENSMUSG00000020053,IGF1,insulin-like growth factor 1 (somatomedin C),extracellular region|extracellular region|extracellular space|plasma membrane|insulin-like growth factor binding protein complex|platelet alpha granule lumen|,"skeletal system development|cell activation|blood vessel remodeling|platelet degranulation|DNA replication|cellular component movement|signal transduction|Ras protein signal transduction|muscle organ development|blood coagulation|positive regulation of cell proliferation|negative regulation of cell proliferation|glycolate metabolic process|glial cell differentiation|positive regulation of cardiac muscle hypertrophy|positive regulation of phosphatidylinositol 3-kinase signaling|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|muscle hypertrophy|myotube cell development|positive regulation of smooth muscle cell migration|positive regulation of cerebellar granule cell precursor proliferation|water homeostasis|proteoglycan biosynthetic process|platelet activation|mammary gland development|exocrine pancreas development|regulation of establishment or maintenance of cell polarity|positive regulation of protein import into nucleus, translocation|negative regulation of smooth muscle cell apoptotic process|multicellular organism growth|bone mineralization involved in bone maturation|regulation of multicellular organism growth|positive regulation of activated T cell proliferation|positive regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of DNA binding|positive regulation of MAPK cascade|positive regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|myoblast differentiation|positive regulation of osteoblast differentiation|positive regulation of glycogen biosynthetic process|positive regulation of DNA replication|positive regulation of DNA replication|positive regulation of glycolytic process|positive regulation of mitosis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glucose import|positive regulation of Ras protein signal transduction|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|lung alveolus development|positive regulation of smooth muscle cell proliferation|branching morphogenesis of an epithelial tube|inner ear development|chondroitin sulfate proteoglycan biosynthetic process|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|myoblast proliferation|positive regulation of protein kinase B signaling|lung vasculature development|lung lobe morphogenesis|Type I pneumocyte differentiation|Type II pneumocyte differentiation|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate gland growth|prostate gland stromal morphogenesis|negative regulation of androgen receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|negative regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of myoblast proliferation|negative regulation of extrinsic apoptotic signaling pathway|",insulin receptor binding|insulin-like growth factor receptor binding|integrin binding|hormone activity|protein binding|growth factor activity|,10,2.6,2.17,10,-0.8,0.803,-0.5,0.0669,0.819,-4.3,6.2
ENSMUSG00000032515,CSRNP1,cysteine-serine-rich nuclear protein 1,nucleus|,"transcription, DNA-templated|apoptotic process|post-embryonic development|positive regulation of transcription from RNA polymerase II promoter|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|palate development|face morphogenesis|",RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|molecular_function|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,9,-0.4,0.133,10,0,0,-0.2,0.0663,0.82,-2.7,2.2
ENSMUSG00000017144,RND3,Rho family GTPase 3,Golgi membrane|extracellular vesicular exosome|,GTP catabolic process|cell adhesion|small GTPase mediated signal transduction|actin cytoskeleton organization|,GTPase activity|protein binding|GTP binding|,10,1,0.201,10,-0.6,0.467,-0.3,0.0663,0.82,-7.2,5.8
ENSMUSG00000024653,SCGB1A1,"secretoglobin, family 1A, member 1 (uteroglobin)",extracellular space|nuclear envelope|rough endoplasmic reticulum|secretory granule|,negative regulation of transcription from RNA polymerase II promoter|signal transduction|female pregnancy|embryo implantation|response to xenobiotic stimulus|response to ozone|response to lipopolysaccharide|negative regulation of interferon-gamma production|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|response to silicon dioxide|response to cytokine|negative regulation of T cell proliferation|response to drug|negative regulation of catalytic activity|regulation of mRNA stability|regulation of inflammatory response|response to glucocorticoid|response to fibroblast growth factor|,protein binding|phospholipase A2 inhibitor activity|,10,-0.5,0.289,10,0,0,-0.2,0.0662,0.82,-6.3,2
ENSMUSG00000027985,LEF1,lymphoid enhancer-binding factor 1,nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|protein-DNA complex|,"negative regulation of transcription from RNA polymerase II promoter|patterning of blood vessels|osteoblast differentiation|neural crest cell migration|somitogenesis|epithelial to mesenchymal transition|sprouting angiogenesis|transcription from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|regulation of striated muscle tissue development|dentate gyrus development|hypothalamus development|forebrain radial glial cell differentiation|forebrain neuroblast division|forebrain neuron differentiation|formation of radial glial scaffolds|regulation of cell-cell adhesion|negative regulation of cell-cell adhesion|positive regulation of cell-cell adhesion|neutrophil differentiation|positive regulation of cell growth|embryonic limb morphogenesis|positive regulation of cell migration|positive regulation of cell migration|BMP signaling pathway|positive regulation of granulocyte differentiation|positive regulation of granulocyte differentiation|mammary gland development|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|T cell receptor V(D)J recombination|B cell proliferation|odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of DNA binding|steroid hormone mediated signaling pathway|tongue development|positive regulation by host of viral transcription|histone H3 acetylation|histone H4 acetylation|T-helper 1 cell differentiation|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|alpha-beta T cell differentiation|eye pigmentation|paraxial mesoderm formation|muscle fiber development|sensory perception of taste|palate development|anatomical structure regression|canonical Wnt signaling pathway|canonical Wnt signaling pathway|face morphogenesis|cell chemotaxis|apoptotic process involved in morphogenesis|chorio-allantoic fusion|trachea gland development|cellular response to cytokine stimulus|cellular response to interleukin-4|positive regulation of cell proliferation in bone marrow|negative regulation of apoptotic process in bone marrow|odontoblast differentiation|negative regulation of estrogen receptor binding|positive regulation of cell cycle process|negative regulation of canonical Wnt signaling pathway|apoptotic process involved in patterning of blood vessels|","RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|beta-catenin binding|beta-catenin binding|beta-catenin binding|transcription factor binding|DNA binding, bending|estrogen receptor activity|estrogen receptor binding|enhancer binding|histone binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|sequence-specific DNA binding|transcription regulatory region DNA binding|gamma-catenin binding|armadillo repeat domain binding|C2H2 zinc finger domain binding|",10,0.8,0.356,10,0,0,0.4,0.066,0.82,-3.3,6.9
ENSMUSG00000039960,RHOU,ras homolog family member U,Golgi membrane|podosome|cytosol|plasma membrane|focal adhesion|cell projection|,G1/S transition of mitotic cell cycle|GTP catabolic process|cytoskeleton organization|small GTPase mediated signal transduction|regulation of cell shape|Rac protein signal transduction|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction|,GTPase activity|protein binding|GTP binding|metal ion binding|,9,-0.4,0.0945,9,0,0,-0.3,0.0656,0.82,-2.8,2.1
ENSMUSG00000020170,FRS2,fibroblast growth factor receptor substrate 2,endosome|plasma membrane|integral component of plasma membrane|membrane|,"activation of MAPKK activity|activation of MAPK activity|gastrulation with mouth forming second|organ induction|ventricular septum development|epidermal growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway|G-protein coupled receptor signaling pathway|neuroblast proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|anterior/posterior axis specification, embryo|forebrain development|Fc-epsilon receptor signaling pathway|innate immune response|optic placode formation involved in camera-type eye formation|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of epithelial cell proliferation|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|",transmembrane receptor protein tyrosine kinase adaptor activity|fibroblast growth factor receptor binding|insulin receptor binding|neurotrophin TRKA receptor binding|protein binding|phosphatase activator activity|,10,-0.4,0.315,10,0,0,-0.2,0.0652,0.82,-4.7,3
ENSMUSG00000027663,ZMAT3,"zinc finger, matrin-type 3",nucleolus|,apoptotic process|cellular response to DNA damage stimulus|protein transport|regulation of growth|positive regulation of apoptotic process|,protein binding|zinc ion binding|poly(A) RNA binding|,10,0.1,0.00478,10,1,0.381,0.3,0.0652,0.82,-3.9,3.3
ENSMUSG00000024365,CYP21A1,"cytochrome P450, family 21, subfamily a, polypeptide 1",endoplasmic reticulum|membrane|intracellular membrane-bounded organelle|,steroid biosynthetic process|C21-steroid hormone biosynthetic process|mineralocorticoid biosynthetic process|progesterone metabolic process|oxidation-reduction process|,"monooxygenase activity|steroid 21-monooxygenase activity|steroid binding|iron ion binding|lipid binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|metal ion binding|",10,-2.6,1.4,10,-0.2,0.0344,-0.2,0.0644,0.821,-8.2,3.3
ENSMUSG00000024397,AIF1,allograft inflammatory factor 1,phagocytic cup|nucleus|nucleus|cytoplasm|cytosol|actin filament|lamellipodium|ruffle membrane|perinuclear region of cytoplasm|,"microglial cell activation|phagocytosis, engulfment|inflammatory response|inflammatory response|Rac protein signal transduction|actin filament polymerization|positive regulation of T cell proliferation|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|actin filament bundle assembly|cellular response to interferon-gamma|cellular response to interferon-gamma|negative regulation of smooth muscle cell chemotaxis|positive regulation of smooth muscle cell chemotaxis|positive regulation of monocyte chemotaxis|ruffle assembly|ruffle assembly|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of T cell migration|",molecular_function|calcium ion binding|actin filament binding|,10,0,0,10,-1.7,0.709,-1.6,0.064,0.821,-6.3,3
ENSMUSG00000024899,PAPSS2,3'-phosphoadenosine 5'-phosphosulfate synthase 2,cytosol|,sulfate assimilation|skeletal system development|carbohydrate metabolic process|xenobiotic metabolic process|blood coagulation|phosphorylation|glycosaminoglycan metabolic process|small molecule metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|bone development|,adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|nucleotidyltransferase activity|,10,0,0,10,0.5,0.287,-0.3,0.063,0.822,-5.5,4.7
ENSMUSG00000024979,TECTB,tectorin beta,proteinaceous extracellular matrix|plasma membrane|anchored component of membrane|,None,None,10,1.2,0.248,10,0,0,0.2,0.0627,0.822,-7.1,6
ENSMUSG00000096923,A730071L15RIK,RIKEN cDNA A730071L15Rik gene,None,None,None,0,0,0,2,-0.4,0.0683,-0.4,0.0622,0.822,-2,1.8
ENSMUSG00000016194,HSD11B1,hydroxysteroid (11-beta) dehydrogenase 1,endoplasmic reticulum membrane|membrane|integral component of membrane|,glucocorticoid biosynthetic process|steroid metabolic process|lung development|small molecule metabolic process|oxidation-reduction process|,11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|,10,0,0,10,-0.4,0.129,-0.2,0.0621,0.822,-3.2,1.6
ENSMUSG00000066878,GM10184,karyopherin (importin) alpha 2 pseudogene,None,None,None,1,0,0,1,0.8,0.226,0.6,0.0608,0.823,-1.8,2
ENSMUSG00000069083,GM10259,karyopherin (importin) alpha 2 pseudogene,None,None,None,1,0,0,1,0.8,0.226,0.6,0.0608,0.823,-1.8,2
ENSMUSG00000019929,DCN,decorin,extracellular region|proteinaceous extracellular matrix|collagen type VI trimer|extracellular space|Golgi lumen|extracellular matrix|extracellular matrix|lysosomal lumen|,kidney development|placenta development|carbohydrate metabolic process|skeletal muscle tissue development|aging|response to mechanical stimulus|organ morphogenesis|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix disassembly|extracellular matrix organization|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|response to lipopolysaccharide|wound healing|small molecule metabolic process|,collagen binding|glycosaminoglycan binding|poly(A) RNA binding|protein N-terminus binding|extracellular matrix binding|,10,-0.4,0.25,10,0.1,0.00431,-0.1,0.0598,0.824,-10.1,3.6
ENSMUSG00000038264,SEMA7A,"semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)",plasma membrane|external side of plasma membrane|membrane|anchored component of membrane|,osteoblast differentiation|inflammatory response|immune response|integrin-mediated signaling pathway|axon guidance|positive regulation of axon extension|regulation of inflammatory response|positive regulation of macrophage cytokine production|positive regulation of ERK1 and ERK2 cascade|,receptor activity|integrin binding|protein binding|,0,0,0,1,-0.5,0.0655,-0.5,0.0596,0.824,-2,1.8
ENSMUSG00000063060,SOX7,SRY (sex determining region Y)-box 7,nucleus|cytoplasm|,"endoderm formation|transcription, DNA-templated|negative regulation of cell proliferation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|regulation of canonical Wnt signaling pathway|",sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|,0,0,0,1,-0.5,0.0655,-0.5,0.0596,0.824,-2,1.8
ENSMUSG00000027398,IL1B,"interleukin 1, beta",extracellular region|extracellular region|extracellular region|extracellular space|extracellular space|cytosol|secretory granule|,"MAPK cascade|activation of MAPK activity|fever generation|positive regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of T cell mediated immunity|apoptotic process|inflammatory response|inflammatory response|immune response|signal transduction|cell-cell signaling|embryo implantation|negative regulation of cell proliferation|response to carbohydrate|positive regulation vascular endothelial growth factor production|positive regulation vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of glucose transport|smooth muscle adaptation|cytokine-mediated signaling pathway|hyaluronan biosynthetic process|neutrophil chemotaxis|sequestering of triglyceride|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|positive regulation of prostaglandin secretion|interleukin-1 beta production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of histone phosphorylation|response to ATP|positive regulation of heterotypic cell-cell adhesion|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|ectopic germ cell programmed cell death|positive regulation of myosin light chain kinase activity|cellular response to drug|positive regulation of T cell proliferation|positive regulation of NF-kappaB import into nucleus|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|protein kinase B signaling|positive regulation of chemokine biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|negative regulation of lipid metabolic process|positive regulation of mitosis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|negative regulation of insulin receptor signaling pathway|positive regulation of protein export from nucleus|regulation of insulin secretion|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell division|positive regulation of cell adhesion molecule production|positive regulation of calcidiol 1-monooxygenase activity|negative regulation of adiponectin secretion|monocyte aggregation|cellular response to mechanical stimulus|cellular response to organic substance|cellular response to organic cyclic compound|positive regulation of monocyte chemotactic protein-1 production|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|",cytokine activity|cytokine activity|interleukin-1 receptor binding|protein domain specific binding|,10,0,0,10,0.8,0.765,0.3,0.059,0.825,-2,3.6
ENSMUSG00000032086,BACE1,beta-site APP-cleaving enzyme 1,endosome|late endosome|multivesicular body|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|cell surface|integral component of membrane|axon|cytoplasmic vesicle membrane|,proteolysis|membrane protein ectodomain proteolysis|beta-amyloid metabolic process|,beta-amyloid binding|aspartic-type endopeptidase activity|protein binding|beta-aspartyl-peptidase activity|enzyme binding|,10,-1,0.344,10,0,0,-0.2,0.0587,0.825,-5.7,4.5
ENSMUSG00000038760,TRHR,thyrotropin-releasing hormone receptor,plasma membrane|integral component of plasma membrane|,G-protein coupled receptor signaling pathway|,thyrotropin-releasing hormone receptor activity|,10,0.9,0.164,10,0.1,0.00242,0.2,0.0584,0.825,-4.7,3.8
ENSMUSG00000029207,APBB2,"amyloid beta (A4) precursor protein-binding, family B, member 2",nucleus|cytoplasm|membrane|lamellipodium|growth cone|synapse|,"neuron migration|regulation of transcription, DNA-templated|cell cycle arrest|axon guidance|extracellular matrix organization|negative regulation of cell growth|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of apoptotic process|",beta-amyloid binding|protein binding|transcription factor binding|,10,0.5,0.297,10,0,0,0.2,0.0582,0.825,-3,4
ENSMUSG00000055197,FEV,FEV (ETS oncogene family),nucleus|,"regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell differentiation|neuron maturation|positive regulation of transcription, DNA-templated|neuron fate specification|",sequence-specific DNA binding RNA polymerase II transcription factor activity|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|sequence-specific DNA binding|,10,0.2,0.0521,10,0.1,0.0161,0.2,0.0563,0.826,-6.2,4
ENSMUSG00000018765,FXR2,"fragile X mental retardation, autosomal homolog 2",cytoplasm|membrane|cytosolic large ribosomal subunit|extracellular vesicular exosome|,None,RNA binding|protein binding|identical protein binding|poly(A) RNA binding|,10,0.3,0.0417,10,0.2,0.0279,0.2,0.0562,0.826,-3.6,3.5
ENSMUSG00000063524,ENO1,"enolase 1, (alpha)",phosphopyruvate hydratase complex|extracellular space|nucleus|nucleus|cytoplasm|cytosol|plasma membrane|membrane|M band|extracellular vesicular exosome|,"negative regulation of transcription from RNA polymerase II promoter|carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|transcription, DNA-templated|response to virus|negative regulation of cell growth|small molecule metabolic process|negative regulation of transcription, DNA-templated|",magnesium ion binding|DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|phosphopyruvate hydratase activity|protein binding|poly(A) RNA binding|,10,0,0,10,-0.3,0.152,-0.2,0.0561,0.827,-7.4,2.3
ENSMUSG00000082229,NAP1L2,nucleosome assembly protein 1-like 2,nucleus|,nucleosome assembly|,protein binding|,9,-0.4,0.128,9,0.2,0.0462,-0.2,0.0561,0.827,-4.7,4.1
ENSMUSG00000024812,TJP2,tight junction protein 2,nucleoplasm|cytoplasm|cytosol|plasma membrane|plasma membrane|adherens junction|tight junction|cell junction|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|response to organic substance|hippo signaling|nucleotide phosphorylation|,guanylate kinase activity|protein binding|protein C-terminus binding|,10,0,0,10,-0.9,0.255,-0.2,0.056,0.827,-3.6,1.9
ENSMUSG00000028635,EDN2,endothelin 2,extracellular region|extracellular space|,prostaglandin biosynthetic process|positive regulation of leukocyte chemotaxis|hormonal regulation of the force of heart contraction|positive regulation of the force of heart contraction by chemical signal|regulation of systemic arterial blood pressure by endothelin|cell surface receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|positive regulation of cell proliferation|positive regulation of heart rate|artery smooth muscle contraction|vein smooth muscle contraction|cytokine-mediated signaling pathway|regulation of vasoconstriction|calcium-mediated signaling|neutrophil chemotaxis|macrophage activation|vasoconstriction|positive regulation of smooth muscle contraction|inositol phosphate-mediated signaling|macrophage chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|,hormone activity|,10,0.6,0.248,10,-0.5,0.114,-0.2,0.0559,0.827,-3.8,3.1
ENSMUSG00000007610,GTPBP3,GTP binding protein 3 (mitochondrial),nucleus|mitochondrion|,GTP catabolic process|tRNA modification|,GTPase activity|GTP binding|,0,0,0,1,0.4,0.0612,0.4,0.0557,0.827,-1.8,2
ENSMUSG00000023046,IGFBP6,insulin-like growth factor binding protein 6,extracellular region|extracellular space|Golgi apparatus|extracellular vesicular exosome|,regulation of cell growth|signal transduction|negative regulation of cell proliferation|cellular protein metabolic process|,insulin-like growth factor I binding|,10,-0.5,0.321,10,0,0,-0.2,0.0557,0.827,-2.7,2.2
ENSMUSG00000000325,ARVCF,armadillo repeat gene deleted in velocardiofacial syndrome,intracellular|nucleus|cytoplasm|plasma membrane|,cell adhesion|multicellular organismal development|single organismal cell-cell adhesion|calcium-dependent cell-cell adhesion|,protein binding|,0,0,0,1,0.4,0.0612,0.4,0.0557,0.827,-1.8,2
ENSMUSG00000037669,1110057K04RIK,RIKEN cDNA 1110057K04 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,0.4,0.0612,0.4,0.0557,0.827,-1.8,2
ENSMUSG00000014226,CACYBP,calcyclin binding protein,nucleus|nuclear envelope lumen|cytoplasm|beta-catenin destruction complex|neuron projection|cell body|extracellular vesicular exosome|,aging|positive regulation of DNA replication|cardiac muscle cell differentiation|response to growth hormone|negative regulation of cell death|cellular response to calcium ion|,protein binding|protein homodimerization activity|,9,-1.7,1.38,10,2.8,1.67,-2,0.055,0.827,-8.6,6.7
ENSMUSG00000041958,PIGS,"phosphatidylinositol glycan anchor biosynthesis, class S",endoplasmic reticulum membrane|membrane|GPI-anchor transamidase complex|,C-terminal protein lipidation|attachment of GPI anchor to protein|post-translational protein modification|cellular protein metabolic process|,GPI-anchor transamidase activity|protein binding|,10,-0.1,0.000905,10,1,1.01,0.3,0.0547,0.828,-2.4,3
ENSMUSG00000055799,TCF7L1,"transcription factor 7-like 1 (T-cell specific, HMG-box)",nucleus|transcription factor complex|,"chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|brain development|anterior/posterior axis specification, embryo|regulation of Wnt signaling pathway|somatic stem cell maintenance|skin development|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter during mitosis|axial mesoderm morphogenesis|generation of neurons|canonical Wnt signaling pathway|regulation of stem cell maintenance|",DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|beta-catenin binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,-3.7,0.615,10,0,0,-0.3,0.0545,0.828,-6.4,1.8
ENSMUSG00000046338,GPAT2,"glycerol-3-phosphate acyltransferase 2, mitochondrial",mitochondrion|mitochondrion|mitochondrial outer membrane|integral component of membrane|,glycerol-3-phosphate metabolic process|phospholipid metabolic process|phosphatidic acid biosynthetic process|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|small molecule metabolic process|glycerophospholipid biosynthetic process|,glycerol-3-phosphate O-acyltransferase activity|,1,0.7,0.212,1,-0.9,0.129,0.5,0.0543,0.828,-1.9,1.9
ENSMUSG00000015619,GATA3,GATA binding protein 3,nuclear chromatin|nucleus|nucleoplasm|nucleolus|,"negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|cell fate determination|neuron migration|type IV hypersensitivity|kidney development|mesonephros development|lens development in camera-type eye|pro-T cell differentiation|aortic valve morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|transcription from RNA polymerase II promoter|defense response|humoral immune response|signal transduction|axon guidance|blood coagulation|negative regulation of cell proliferation|male gonad development|response to virus|anatomical structure morphogenesis|post-embryonic development|positive regulation of signal transduction|response to gamma radiation|positive regulation of endothelial cell migration|phosphatidylinositol 3-kinase signaling|erythrocyte differentiation|TOR signaling|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|negative regulation of mammary gland epithelial cell proliferation|embryonic hemopoiesis|cellular response to interferon-alpha|ureter maturation|parathyroid hormone secretion|regulation of cytokine biosynthetic process|norepinephrine biosynthetic process|inner ear morphogenesis|response to drug|regulation of CD4-positive, alpha-beta T cell differentiation|regulation of neuron apoptotic process|ear development|response to estrogen|thymic T cell selection|T-helper 2 cell differentiation|innate immune response|response to ethanol|positive regulation of T cell differentiation|negative regulation of fat cell differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|cell maturation|sympathetic nervous system development|thymus development|developmental growth|anatomical structure formation involved in morphogenesis|negative regulation of inflammatory response|T cell receptor signaling pathway|regulation of histone H3-K4 methylation|positive regulation of protein kinase B signaling|parathyroid gland development|pharyngeal system development|uterus development|mesenchymal to epithelial transition|mast cell differentiation|ureteric bud formation|regulation of histone H3-K27 methylation|canonical Wnt signaling pathway involved in metanephric kidney development|cellular response to interleukin-4|cellular response to tumor necrosis factor|otic vesicle development|cellular response to BMP stimulus|positive regulation of ureteric bud formation|nephric duct morphogenesis|nephric duct formation|regulation of nephron tubule epithelial cell differentiation|interleukin-4 secretion|interferon-gamma secretion|lymphocyte migration|regulation of establishment of cell polarity|negative regulation of cell motility|negative regulation of endothelial cell apoptotic process|negative regulation of cell proliferation involved in mesonephros development|positive regulation of thyroid hormone generation|positive regulation of interleukin-5 secretion|positive regulation of interleukin-13 secretion|positive regulation of interleukin-13 secretion|positive regulation of transcription regulatory region DNA binding|regulation of cellular response to X-ray|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|",transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|nucleic acid binding transcription factor activity|nucleic acid binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|enhancer sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|interleukin-2 receptor binding|protein binding|transcription factor binding|zinc ion binding|transcription regulatory region DNA binding|protein dimerization activity|E-box binding|HMG box domain binding|,9,0.2,0.0643,10,0.1,0.00722,0.2,0.0539,0.828,-2,3.5
ENSMUSG00000061731,EXT1,exostosin glycosyltransferase 1,Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral component of membrane|integral component of endoplasmic reticulum membrane|,"skeletal system development|ossification|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan biosynthetic process|protein glycosylation|signal transduction|gastrulation|axon guidance|endoderm development|mesoderm development|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|olfactory bulb development|glycosaminoglycan metabolic process|cellular polysaccharide biosynthetic process|small molecule metabolic process|embryonic skeletal joint development|","acetylglucosaminyltransferase activity|glucuronosyltransferase activity|transferase activity, transferring glycosyl groups|heparan sulfate N-acetylglucosaminyltransferase activity|protein homodimerization activity|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|",10,0,0,10,0.5,0.373,0.2,0.0537,0.828,-3.1,4.1
ENSMUSG00000019846,LAMA4,"laminin, alpha 4",extracellular region|basement membrane|basal lamina|laminin-1 complex|extracellular matrix|extracellular vesicular exosome|,blood vessel development|cell adhesion|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|regulation of embryonic development|brown fat cell differentiation|,receptor binding|extracellular matrix structural constituent|,10,0.6,0.179,10,0.1,0.015,0.2,0.0536,0.828,-3.1,4
ENSMUSG00000019961,TMPO,thymopoietin,chromatin|nucleus|nucleus|nuclear envelope|nuclear inner membrane|membrane|integral component of membrane|nuclear membrane|,"regulation of transcription, DNA-templated|",DNA binding|protein binding|lamin binding|,10,0.2,0.0367,10,-0.2,0.0645,-0.2,0.0533,0.828,-4.2,2.9
ENSMUSG00000008658,RBFOX1,"RNA binding protein, fox-1 homolog (C. elegans) 1",nucleus|cytoplasm|trans-Golgi network|,mRNA processing|RNA splicing|regulation of RNA splicing|RNA transport|neuromuscular process controlling balance|,nucleotide binding|RNA binding|protein binding|protein C-terminus binding|,1,0,0,1,-1.6,0.334,-1.4,0.0528,0.829,-3,1.7
ENSMUSG00000032624,EML4,echinoderm microtubule associated protein like 4,cytoplasm|microtubule|membrane|mitotic spindle|,microtubule-based process|negative regulation of microtubule depolymerization|mitotic nuclear division|,molecular_function|,10,-0.2,0.0301,10,-0.1,0.0275,-0.1,0.052,0.829,-8.8,3
ENSMUSG00000030465,PSD3,pleckstrin and Sec7 domain containing 3,postsynaptic density|cell junction|postsynaptic membrane|,neuron differentiation|regulation of ARF protein signal transduction|positive regulation of GTPase activity|positive regulation of GTPase activity|,ARF guanyl-nucleotide exchange factor activity|,10,0,0,10,-0.2,0.0942,-0.1,0.0519,0.83,-3.8,3.3
ENSMUSG00000048806,IFNB1,"interferon, beta 1, fibroblast",extracellular region|extracellular region|extracellular space|,adaptive immune response|T cell activation involved in immune response|B cell activation involved in immune response|natural killer cell activation involved in immune response|humoral immune response|cell surface receptor signaling pathway|blood coagulation|response to virus|cytokine-mediated signaling pathway|cytokine-mediated signaling pathway|natural killer cell activation|B cell differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|cellular response to interferon-beta|B cell proliferation|defense response to bacterium|response to exogenous dsRNA|negative regulation of viral genome replication|innate immune response|positive regulation of innate immune response|regulation of MHC class I biosynthetic process|negative regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|type I interferon signaling pathway|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|cellular response to exogenous dsRNA|negative regulation of T-helper 2 cell cytokine production|positive regulation of apoptotic signaling pathway|,cytokine activity|cytokine activity|type I interferon receptor binding|,10,-0.6,0.317,10,0,0,-0.2,0.0516,0.83,-6.7,2
ENSMUSG00000020235,FZR1,fizzy/cell division cycle 20 related 1 (Drosophila),nucleus|nucleoplasm|anaphase-promoting complex|cytosol|nuclear membrane|,mitotic cell cycle|DNA repair|mitotic nuclear division|positive regulation of cell proliferation|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G2 DNA damage checkpoint|regulation of meiosis|positive regulation of protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|activation of anaphase-promoting complex activity|lens fiber cell differentiation|protein K11-linked ubiquitination|negative regulation of cell aging|,protein binding|,10,-2.7,0.564,10,-1,0.208,-0.3,0.0512,0.83,-9,7
ENSMUSG00000038366,LASP1,LIM and SH3 protein 1,focal adhesion|cortical actin cytoskeleton|extracellular vesicular exosome|,ion transport|positive regulation of signal transduction|ion transmembrane transport|,SH3/SH2 adaptor activity|protein binding|zinc ion binding|ion transmembrane transporter activity|actin filament binding|,10,0,0,10,-1.1,0.607,-0.2,0.0498,0.831,-7.3,2.9
ENSMUSG00000047454,GPHN,gephyrin,cytoplasm|cytoskeleton|plasma membrane|cell junction|postsynaptic membrane|,vitamin metabolic process|water-soluble vitamin metabolic process|Mo-molybdopterin cofactor biosynthetic process|establishment of synaptic specificity at neuromuscular junction|molybdopterin cofactor biosynthetic process|small molecule metabolic process|,ATP binding|transferase activity|metal ion binding|molybdopterin adenylyltransferase activity|molybdopterin molybdotransferase activity|,10,-0.7,0.293,10,2.5,1.13,-0.2,0.0494,0.831,-4.4,5.1
ENSMUSG00000031380,FIGF,c-fos induced growth factor (vascular endothelial growth factor D),extracellular region|extracellular space|membrane|platelet alpha granule lumen|,angiogenesis|platelet degranulation|blood coagulation|cell proliferation|positive regulation of cell proliferation|cell differentiation|platelet activation|vascular endothelial growth factor receptor signaling pathway|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis|,platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor binding|growth factor activity|chemoattractant activity|protein homodimerization activity|vascular endothelial growth factor receptor 3 binding|,9,0,0,10,-0.4,0.0974,-0.2,0.0492,0.832,-3.7,3.3
ENSMUSG00000062352,ITGB1BP1,integrin beta 1 binding protein 1,ruffle|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|membrane|lamellipodium|perinuclear region of cytoplasm|extracellular vesicular exosome|cell periphery|,"blood vessel endothelial cell proliferation involved in sprouting angiogenesis|transcription, DNA-templated|negative regulation of protein kinase activity|negative regulation of cell adhesion involved in substrate-bound cell migration|cell-matrix adhesion|Notch signaling pathway|integrin-mediated signaling pathway|positive regulation of cell proliferation|negative regulation of cell proliferation|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|protein transport|cell migration|cell differentiation|biomineral tissue development|negative regulation of protein binding|activation of protein kinase B activity|integrin activation|regulation of cell adhesion mediated by integrin|tube formation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|regulation of Cdc42 GTPase activity|receptor clustering|cellular response to fibroblast growth factor stimulus|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|myoblast migration|positive regulation of stress fiber assembly|positive regulation of cell division|positive regulation of focal adhesion assembly|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|negative regulation of protein targeting to membrane|negative regulation of substrate adhesion-dependent cell spreading|regulation of integrin-mediated signaling pathway|",GDP-dissociation inhibitor activity|integrin binding|integrin binding|protein binding|protein transporter activity|protein kinase binding|protein complex binding|,10,0.1,0.0131,10,0.2,0.0442,0.2,0.0487,0.832,-2.5,3.1
ENSMUSG00000016520,LNX2,ligand of numb-protein X 2,None,protein homooligomerization|,protein binding|zinc ion binding|PDZ domain binding|,10,-0.5,0.263,10,0,0,-0.2,0.0481,0.832,-8,3.8
ENSMUSG00000068205,MACROD2,MACRO domain containing 2,nucleus|,cellular response to DNA damage stimulus|brain development|purine nucleoside metabolic process|protein de-ADP-ribosylation|,"hydrolase activity, acting on glycosyl bonds|deacetylase activity|",10,-0.3,0.0937,10,0,0,-0.2,0.0477,0.833,-3.7,2
ENSMUSG00000021245,MLH3,mutL homolog 3,synaptonemal complex|male germ cell nucleus|nucleus|chiasma|mismatch repair complex|,ATP catabolic process|mismatch repair|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis|female meiosis I|protein localization|,chromatin binding|satellite DNA binding|single-stranded DNA binding|protein binding|ATP binding|ATPase activity|centromeric DNA binding|mismatched DNA binding|,10,1.7,0.827,10,-2.5,0.601,0.2,0.0476,0.833,-7.8,4.3
ENSMUSG00000025527,SATL1,spermidine/spermine N1-acetyl transferase-like 1,None,metabolic process|,N-acetyltransferase activity|,9,1.1,1.15,10,-0.3,0.0988,-0.2,0.0472,0.833,-3.5,4.3
ENSMUSG00000091490,TRIML2,tripartite motif family-like 2,None,protein ubiquitination|response to retinoic acid|,ligase activity|,1,-0.4,0.051,0,0,0,-0.4,0.0464,0.834,-2,1.8
ENSMUSG00000027452,ACSS1,acyl-CoA synthetase short-chain family member 1,mitochondrial matrix|mitochondrial matrix|,ethanol oxidation|acetyl-CoA biosynthetic process|xenobiotic metabolic process|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|small molecule metabolic process|,acetate-CoA ligase activity|protein binding|ATP binding|AMP binding|,10,0,0,10,-0.3,0.107,-0.2,0.0461,0.834,-5,2
ENSMUSG00000022840,ADCY5,adenylate cyclase 5,plasma membrane|plasma membrane|integral component of membrane|primary cilium|,adenosine receptor signaling pathway|energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|locomotory behavior|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|neuromuscular process controlling balance|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|ATP binding|adenylate cyclase binding|metal ion binding|protein heterodimerization activity|,10,0.2,0.0863,10,0,0,0.1,0.0461,0.834,-7.4,4.7
ENSMUSG00000040205,CUZD1,CUB and zona pellucida-like domains 1,integral component of membrane|transport vesicle membrane|zymogen granule membrane|,"substrate-dependent cell migration, cell attachment to substrate|cell cycle|cell proliferation|trypsinogen activation|cell division|",None,10,-0.4,0.183,10,0,0,-0.1,0.0457,0.835,-10.7,3.1
ENSMUSG00000025925,TERF1,telomeric repeat binding factor (NIMA-interacting) 1,"chromosome, telomeric region|nuclear telomere cap complex|nuclear telomere cap complex|nucleus|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|spindle|",G2/M transition of mitotic cell cycle|telomere maintenance|age-dependent telomere shortening|telomere maintenance via telomerase|telomere maintenance via telomerase|mitotic nuclear division|mitotic spindle assembly checkpoint|negative regulation of DNA replication|telomere maintenance via telomere shortening|positive regulation of microtubule polymerization|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|response to drug|positive regulation of apoptotic process|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|negative regulation of telomerase activity|,"DNA binding|chromatin binding|double-stranded telomeric DNA binding|protein binding|microtubule binding|DNA binding, bending|telomeric DNA binding|protein homodimerization activity|protein heterodimerization activity|",9,0,0,9,0.8,1.19,0.5,0.0456,0.835,-5.4,6.6
ENSMUSG00000020155,KCNMB1,"potassium large conductance calcium-activated channel, subfamily M, beta member 1",plasma membrane|voltage-gated potassium channel complex|,potassium ion transport|synaptic transmission|blood coagulation|response to calcium ion|potassium ion transmembrane transport|potassium ion transmembrane transport|,calcium-activated potassium channel activity|potassium channel regulator activity|,0,0,0,1,-0.4,0.0497,-0.4,0.0453,0.835,-2,1.8
ENSMUSG00000021550,2210016F16RIK,RIKEN cDNA 2210016F16 gene,cellular_component|,biological_process|,molecular_function|,0,0,0,1,-0.4,0.0497,-0.4,0.0453,0.835,-2,1.8
ENSMUSG00000028071,SH2D2A,SH2 domain containing 2A,cytoplasm|,angiogenesis|signal transduction|cell proliferation|positive regulation of signal transduction|cell differentiation|,SH3/SH2 adaptor activity|protein binding|SH3 domain binding|,0,0,0,1,-0.4,0.0497,-0.4,0.0453,0.835,-2,1.8
ENSMUSG00000024431,NR3C1,"nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)",nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|membrane|,"regulation of gluconeogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|signal transduction|glucocorticoid metabolic process|gene expression|chromatin modification|adrenal gland development|regulation of glucocorticoid biosynthetic process|glucocorticoid receptor signaling pathway|glucocorticoid mediated signaling pathway|positive regulation of neuron apoptotic process|positive regulation of transcription from RNA polymerase II promoter|mammary gland duct morphogenesis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|glucocorticoid receptor activity|steroid binding|protein binding|zinc ion binding|protein dimerization activity|,10,0,0,10,0.2,0.0652,0.2,0.0452,0.835,-3.1,2.6
ENSMUSG00000036822,TOPORS,"topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase",ubiquitin ligase complex|spindle pole|gamma-tubulin complex|nucleus|centriole|cytoplasmic dynein complex|PML body|PML body|nuclear speck|midbody|photoreceptor connecting cilium|ciliary basal body|,"transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|intrinsic apoptotic signaling pathway in response to DNA damage|retina layer formation|protein sumoylation|protein sumoylation|protein localization to nucleus|photoreceptor cell outer segment organization|regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|retinal rod cell development|retinal cone cell development|positive regulation of ubiquitin-protein transferase activity|maintenance of protein location in nucleus|protein K48-linked ubiquitination|",DNA binding|antigen binding|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|SUMO ligase activity|SUMO ligase activity|DNA topoisomerase binding|,9,0,0,10,0.5,0.309,0.1,0.0451,0.835,-3,4
ENSMUSG00000022770,DLG1,"discs, large homolog 1 (Drosophila)",immunological synapse|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|plasma membrane|cell-cell junction|tight junction|cytoplasmic side of plasma membrane|postsynaptic density|intercalated disc|basolateral plasma membrane|lateral plasma membrane|cell junction|cell projection membrane|neuromuscular junction|node of Ranvier|myelin sheath abaxonal region|sarcolemma|lateral loop|membrane raft|postsynaptic membrane|perinuclear region of cytoplasm|extracellular vesicular exosome|MPP7-DLG1-LIN7 complex|,branching involved in ureteric bud morphogenesis|immunological synapse formation|endothelial cell proliferation|lens development in camera-type eye|T cell cytokine production|actin filament organization|mitotic cell cycle checkpoint|establishment or maintenance of cell polarity|synaptic transmission|axon guidance|positive regulation of cell proliferation|viral process|dephosphorylation|single organismal cell-cell adhesion|peristalsis|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|membrane raft organization|activation of protein kinase activity|T cell activation|negative regulation of T cell proliferation|regulation of membrane potential|amyloid precursor protein metabolic process|positive regulation of potassium ion transport|negative regulation of mitotic cell cycle|nucleotide phosphorylation|reproductive structure development|embryonic skeletal system morphogenesis|smooth muscle tissue development|negative regulation of epithelial cell proliferation|hard palate development|tight junction assembly|protein localization to plasma membrane|protein localization to plasma membrane|positive regulation of establishment of protein localization to plasma membrane|regulation of sodium ion transmembrane transport|,guanylate kinase activity|phosphoprotein phosphatase activity|protein binding|protein C-terminus binding|cytoskeletal protein binding|potassium channel regulator activity|potassium channel regulator activity|protein kinase binding|phosphatase binding|mitogen-activated protein kinase kinase binding|protein complex scaffold|ion channel binding|L27 domain binding|,8,-1.5,0.161,9,5.8,1.92,-0.1,0.045,0.835,-4.7,11.6
ENSMUSG00000005886,NCOA2,nuclear receptor coactivator 2,nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|histone acetylation|androgen receptor signaling pathway|cellular lipid metabolic process|small molecule metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of receptor activity|",chromatin binding|transcription coactivator activity|transcription coactivator activity|histone acetyltransferase activity|signal transducer activity|protein binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|thyroid hormone receptor coactivator activity|nuclear hormone receptor binding|protein dimerization activity|,10,-0.1,0.0233,10,-0.2,0.0264,-0.2,0.0446,0.835,-3.4,3
ENSMUSG00000040732,ERG,v-ets avian erythroblastosis virus E26 oncogene homolog,nucleus|cytoplasm|ribonucleoprotein complex|,regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|protein phosphorylation|signal transduction|multicellular organismal development|cell proliferation|cell differentiation|,sequence-specific DNA binding RNA polymerase II transcription factor activity|DNA binding|signal transducer activity|protein binding|sequence-specific DNA binding|,10,0,0,10,-2.1,1.59,-1.2,0.0428,0.836,-6.4,2.2
ENSMUSG00000020828,PLD2,phospholipase D2,endoplasmic reticulum membrane|plasma membrane|brush border membrane|,G-protein coupled receptor internalization|phospholipid metabolic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|cytoskeleton organization|small GTPase mediated signal transduction|lipid catabolic process|Fc-gamma receptor signaling pathway involved in phagocytosis|small molecule metabolic process|innate immune response|glycerophospholipid biosynthetic process|,phospholipase D activity|protein binding|phosphatidylinositol binding|N-acylphosphatidylethanolamine-specific phospholipase D activity|,10,0,0,10,-0.3,0.175,-0.2,0.0425,0.837,-5.3,2.6
ENSMUSG00000024989,CEP55,centrosomal protein 55kDa,centrosome|centriole|membrane|midbody|cleavage furrow|intercellular bridge|,mitotic cytokinesis|mitotic nuclear division|establishment of protein localization|,protein binding|,10,-4,2.23,10,0.7,0.521,0.2,0.042,0.837,-8.1,3.4
ENSMUSG00000058076,SDHC,"succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa",mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex II|integral component of membrane|respiratory chain complex II|,tricarboxylic acid cycle|tricarboxylic acid cycle|aerobic respiration|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|oxidation-reduction process|,succinate dehydrogenase activity|electron carrier activity|heme binding|metal ion binding|,10,-0.1,0.00242,10,-0.2,0.0563,-0.1,0.041,0.838,-3.7,3.4
ENSMUSG00000033016,NFATC1,"nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1",nuclear chromatin|nucleoplasm|transcription factor complex|cytoplasm|cytosol|,"G1/S transition of mitotic cell cycle|epithelial to mesenchymal transition|transcription from RNA polymerase II promoter|calcium ion transport|heart development|osteoclast differentiation|intracellular signal transduction|Fc-epsilon receptor signaling pathway|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|FK506 binding|transcription regulatory region DNA binding|mitogen-activated protein kinase p38 binding|,9,0,0,9,0.6,0.121,0.1,0.041,0.838,-2.8,4.5
ENSMUSG00000090315,VMN2R104,"vomeronasal 2, receptor 104",plasma membrane|membrane|integral component of membrane|,signal transduction|G-protein coupled receptor signaling pathway|,signal transducer activity|G-protein coupled receptor activity|,10,0.7,0.869,10,-0.4,0.191,0.2,0.0409,0.838,-4.7,4.4
ENSMUSG00000039959,HIP1,huntingtin interacting protein 1,nucleus|cytoplasm|Golgi apparatus|cytoskeleton|membrane|clathrin-coated vesicle|clathrin-coated vesicle membrane|intracellular membrane-bounded organelle|,"transcription, DNA-templated|regulation of transcription, DNA-templated|endocytosis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell differentiation|regulation of apoptotic process|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|apoptotic signaling pathway|",actin binding|structural constituent of cytoskeleton|protein binding|clathrin binding|phosphatidylinositol binding|,10,0.1,0.0021,10,0.2,0.0549,0.1,0.04,0.839,-5,3.7
ENSMUSG00000056220,PLA2G4A,"phospholipase A2, group IVA (cytosolic, calcium-dependent)",cytoplasm|mitochondrial inner membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cytosol|cytoplasmic membrane-bounded vesicle|,phospholipid metabolic process|phosphatidic acid biosynthetic process|platelet activating factor biosynthetic process|icosanoid metabolic process|blood coagulation|phospholipid catabolic process|arachidonic acid metabolic process|platelet activation|cardiolipin acyl-chain remodeling|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|regulation of cell proliferation|small molecule metabolic process|icosanoid biosynthetic process|glycerophospholipid biosynthetic process|arachidonic acid secretion|cellular response to antibiotic|,lysophospholipase activity|phospholipase A2 activity|phospholipase A2 activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent phospholipase A2 activity|,10,-1.9,0.674,10,-0.2,0.03,-0.3,0.0399,0.839,-4.8,2.7
ENSMUSG00000019861,GOPC,golgi-associated PDZ and coiled-coil motif containing,Golgi membrane|cytoplasm|Golgi apparatus|plasma membrane|postsynaptic density|membrane|cell junction|trans-Golgi network transport vesicle|trans-Golgi network transport vesicle|dendrite|protein complex|postsynaptic membrane|,ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|spermatid nucleus differentiation|protein transport|cytoplasmic sequestering of CFTR protein|apical protein localization|regulation of catalytic activity|protein homooligomerization|,small GTPase regulator activity|frizzled binding|protein binding|protein C-terminus binding|protein homodimerization activity|ion channel binding|,10,-0.7,0.0683,10,-0.1,0.0112,-0.2,0.0398,0.839,-5,2.9
ENSMUSG00000072582,PTRH2,peptidyl-tRNA hydrolase 2,mitochondrion|mitochondrion|cytosol|membrane|,apoptotic process|metabolic process|negative regulation of gene expression|positive regulation of anoikis|negative regulation of anoikis|,aminoacyl-tRNA hydrolase activity|protein binding|,10,0.6,0.199,10,-0.2,0.0522,0.2,0.0398,0.839,-3.8,3.3
ENSMUSG00000070390,NLRP1B,"NLR family, pyrin domain containing 1B",nucleus|NLRP1 inflammasome complex|,activation of cysteine-type endopeptidase activity involved in apoptotic process|protein catabolic process|interleukin-1 alpha production|interleukin-1 beta production|interleukin-1 beta production|neuron apoptotic process|pyroptosis|,nucleotide binding|ATP binding|enzyme binding|protein domain specific binding|,9,-0.9,0.464,10,0.2,0.0709,-0.4,0.0395,0.839,-5.5,3
ENSMUSG00000058488,KL,klotho,extracellular region|extracellular space|extracellular space|plasma membrane|integral component of plasma membrane|integral component of membrane|extracellular vesicular exosome|,acute inflammatory response|carbohydrate metabolic process|energy reserve metabolic process|epidermal growth factor receptor signaling pathway|aging|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|positive regulation of bone mineralization|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|calcium ion homeostasis|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|,beta-glucuronidase activity|signal transducer activity|fibroblast growth factor receptor binding|hormone activity|vitamin D binding|beta-glucosidase activity|fibroblast growth factor binding|,10,0,0,10,-0.7,0.396,-0.5,0.0384,0.84,-5.2,2.7
ENSMUSG00000024233,LYZL1,lysozyme-like 1,extracellular region|,cell wall macromolecule catabolic process|,lysozyme activity|,10,0,0,10,0.2,0.113,0.2,0.0379,0.841,-1.7,2.4
ENSMUSG00000001761,SMO,"smoothened, frizzled class receptor",cytoplasm|Golgi apparatus|plasma membrane|plasma membrane|caveola|cilium|integral component of membrane|neuronal cell body|intracellular membrane-bounded organelle|ciliary membrane|extracellular vesicular exosome|primary cilium|,negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|osteoblast differentiation|in utero embryonic development|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|heart morphogenesis|determination of left/right asymmetry in lateral mesoderm|type B pancreatic cell development|G-protein coupled receptor signaling pathway|smoothened signaling pathway|smoothened signaling pathway|positive regulation of hh target transcription factor activity|spermatogenesis|determination of left/right symmetry|ventral midline determination|midgut development|gonad development|cardioblast differentiation|positive regulation of gene expression|negative regulation of gene expression|floor plate formation|facial nerve development|cerebellar cortex morphogenesis|thalamus development|dorsal/ventral neural tube patterning|smoothened signaling pathway involved in ventral spinal cord patterning|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|central nervous system neuron differentiation|adenohypophysis development|negative regulation of epithelial cell differentiation|exocrine pancreas development|hair follicle morphogenesis|embryonic camera-type eye development|neuron projection regeneration|otolith morphogenesis|protein localization to nucleus|multicellular organism growth|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|muscle cell fate commitment|negative regulation of apoptotic process|negative regulation of DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract morphogenesis|neuron fate commitment|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|semicircular canal morphogenesis|axon extension involved in axon guidance|forebrain morphogenesis|positive regulation of epithelial cell proliferation|protein stabilization|negative regulation of hair follicle development|canonical Wnt signaling pathway|detection of cell density by contact stimulus involved in contact inhibition|atrial septum morphogenesis|mammary gland epithelial cell differentiation|epithelial-mesenchymal cell signaling|ciliary receptor clustering involved in smoothened signaling pathway|somite development|pancreas morphogenesis|cellular response to cholesterol|renal system development|mesenchymal to epithelial transition involved in metanephric renal vesicle formation|positive regulation of branching involved in ureteric bud morphogenesis|regulation of stem cell maintenance|regulation of heart morphogenesis|,G-protein coupled receptor activity|patched binding|protein binding|drug binding|Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|,10,-0.2,0.0768,10,0,0,-0.1,0.0374,0.841,-2,2.7
ENSMUSG00000019856,FAM184A,"family with sequence similarity 184, member A",extracellular space|,biological_process|,molecular_function|,10,0,0,10,0.3,0.0876,0.2,0.0372,0.841,-1.5,2.6
ENSMUSG00000040860,CROCC,"ciliary rootlet coiled-coil, rootletin",cytoplasm|centrosome|centriole|centriole|plasma membrane|actin cytoskeleton|ciliary rootlet|extracellular vesicular exosome|,cell cycle|protein localization|centriole-centriole cohesion|cell projection organization|protein localization to organelle|centrosome organization|,structural molecule activity|protein binding|kinesin binding|,10,-0.1,0.00431,10,1.2,0.527,-0.1,0.0367,0.842,-5.3,5.7
ENSMUSG00000021482,AAED1,AhpC/TSA antioxidant enzyme domain containing 1,None,None,None,1,0.3,0.0401,0,0,0,0.3,0.0365,0.842,-1.8,2
ENSMUSG00000066800,RNASEL,"ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)",cellular_component|mitochondrion|cytosol|nuclear matrix|,"rRNA processing|mRNA processing|protein phosphorylation|cytokine-mediated signaling pathway|negative regulation of viral genome replication|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|type I interferon signaling pathway|RNA phosphodiester bond hydrolysis, endonucleolytic|",RNA binding|endoribonuclease activity|protein kinase activity|protein binding|ATP binding|rRNA binding|metal ion binding|,10,-1.8,0.241,10,1.2,0.442,0.2,0.0362,0.842,-8.2,4.5
ENSMUSG00000039997,IFI203,interferon activated gene 203,nucleus|nucleolus|cytoplasm|membrane|,cellular response to interferon-beta|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,9,-1.6,1.18,9,4.5,0.792,-1.2,0.036,0.842,-5.4,8.5
ENSMUSG00000022074,TNFRSF10B,"tumor necrosis factor receptor superfamily, member 10b",plasma membrane|integral component of membrane|,apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|extrinsic apoptotic signaling pathway via death domain receptors|response to endoplasmic reticulum stress|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to mechanical stimulus|apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|,receptor activity|protein binding|TRAIL binding|,10,-1.6,1.03,10,0.6,0.518,-0.2,0.0359,0.842,-3.9,2.5
ENSMUSG00000000320,ALOX12,arachidonate 12-lipoxygenase,cytoplasm|cytosol|cytosol|membrane|sarcolemma|extracellular vesicular exosome|,cellular component movement|aging|positive regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of muscle cell apoptotic process|arachidonic acid metabolic process|arachidonic acid metabolic process|arachidonic acid metabolic process|lipoxygenase pathway|lipoxygenase pathway|fatty acid oxidation|positive regulation of cell growth|positive regulation of cell migration|superoxide anion generation|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|linoleic acid metabolic process|small molecule metabolic process|positive regulation of endothelial cell differentiation|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of vasodilation|positive regulation of smooth muscle cell proliferation|hepoxilin metabolic process|hepoxilin biosynthetic process|positive regulation of mitochondrial depolarization|establishment of skin barrier|cellular response to lipid|reactive oxygen species metabolic process|negative regulation of platelet aggregation|leukotriene A4 metabolic process|lipoxin metabolic process|lipoxin A4 biosynthetic process|lipoxin B4 biosynthetic process|,"arachidonate 12-lipoxygenase activity|arachidonate 12-lipoxygenase activity|iron ion binding|protein binding|linoleate 13S-lipoxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|hepoxilin-epoxide hydrolase activity|hepoxilin A3 synthase activity|",10,0.4,0.12,10,0,0,0.1,0.0353,0.843,-2.5,3.1
ENSMUSG00000026825,DNM1,dynamin 1,microtubule|membrane coat|,GTP catabolic process|GTP catabolic process|endocytosis|receptor-mediated endocytosis|endosome organization|receptor internalization|,GTPase activity|protein binding|GTP binding|protein C-terminus binding|protein kinase binding|protein complex binding|identical protein binding|poly(A) RNA binding|,10,0,0,10,1.1,0.462,0.1,0.0351,0.843,-2.6,4.6
ENSMUSG00000043822,ADAMTSL5,ADAMTS-like 5,microfibril|microfibril|extracellular region|proteinaceous extracellular matrix|extracellular matrix|,proteolysis|,metalloendopeptidase activity|heparin binding|zinc ion binding|,10,-0.3,0.0942,10,0.4,0.128,-0.2,0.0348,0.843,-3.5,3.6
ENSMUSG00000026638,IRF6,interferon regulatory factor 6,nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,"transcription, DNA-templated|cell cycle arrest|negative regulation of cell proliferation|cytokine-mediated signaling pathway|keratinocyte differentiation|keratinocyte proliferation|positive regulation of transcription, DNA-templated|cell development|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|mammary gland epithelial cell differentiation|",regulatory region DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,1,-0.3,0.0381,0,0,0,-0.3,0.0346,0.844,-2,1.8
ENSMUSG00000025204,NDUFB8,"NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa",mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|endoplasmic reticulum|integral component of membrane|,"mitochondrial electron transport, NADH to ubiquinone|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|",NADH dehydrogenase (ubiquinone) activity|,10,-0.5,0.306,10,0,0,-0.1,0.0341,0.844,-7.9,5.5
ENSMUSG00000041120,NBL1,"neuroblastoma 1, DAN family BMP antagonist",extracellular space|,nervous system development|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|sequestering of BMP from receptor via BMP binding|positive regulation of neuron differentiation|determination of dorsal identity|neuron projection morphogenesis|negative regulation of monocyte chemotaxis|,morphogen activity|BMP binding|protein homodimerization activity|,10,-0.5,0.191,10,0,0,-0.1,0.0338,0.844,-4.7,3.9
ENSMUSG00000032402,SMAD3,SMAD family member 3,nuclear chromatin|nucleus|nuclear inner membrane|nucleoplasm|transcription factor complex|cytoplasm|cytosol|plasma membrane|receptor complex|SMAD protein complex|SMAD2-SMAD3 protein complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|ureteric bud development|response to hypoxia|in utero embryonic development|mesoderm formation|somitogenesis|liver development|negative regulation of protein phosphorylation|heart looping|osteoblast development|immune system development|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|endoderm development|embryonic pattern specification|gene expression|positive regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|evasion or tolerance of host defenses by virus|signal transduction involved in regulation of gene expression|negative regulation of cell growth|positive regulation of cell migration|positive regulation of bone mineralization|negative regulation of transforming growth factor beta receptor signaling pathway|thyroid gland development|primary miRNA processing|positive regulation of chondrocyte differentiation|positive regulation of interleukin-1 beta production|regulation of transforming growth factor beta2 production|positive regulation of transforming growth factor beta3 production|activin receptor signaling pathway|negative regulation of osteoblast proliferation|positive regulation of catenin import into nucleus|intracellular signal transduction|nodal signaling pathway|wound healing|T cell activation|negative regulation of protein catabolic process|positive regulation of transcription factor import into nucleus|negative regulation of apoptotic process|cell-cell junction organization|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|negative regulation of inflammatory response|regulation of immune response|protein stabilization|positive regulation of positive chemotaxis|regulation of binding|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|pericardium development|transdifferentiation|negative regulation of wound healing|lens fiber cell differentiation|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of gene expression involved in extracellular matrix organization|","core promoter proximal region sequence-specific DNA binding|protein binding transcription factor activity|RNA polymerase II activating transcription factor binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|collagen binding|beta-catenin binding|transcription factor binding|zinc ion binding|protein kinase binding|phosphatase binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|chromatin DNA binding|ubiquitin protein ligase binding|enhancer binding|protein homodimerization activity|ubiquitin binding|bHLH transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|co-SMAD binding|R-SMAD binding|",10,-0.5,0.0963,10,0.5,0.372,0.1,0.0332,0.845,-2.7,3.7
ENSMUSG00000013611,SNX31,sorting nexin 31,None,protein transport|,phosphatidylinositol binding|,1,0.3,0.0359,0,0,0,0.3,0.0326,0.846,-1.8,2
ENSMUSG00000059003,GRIN2A,"glutamate receptor, ionotropic, N-methyl D-aspartate 2A",endoplasmic reticulum|plasma membrane|integral component of plasma membrane|synaptic vesicle|cell surface|N-methyl-D-aspartate selective glutamate receptor complex|cell junction|dendrite|presynaptic membrane|postsynaptic membrane|neuronal postsynaptic density|,"startle response|response to amphetamine|transport|glutamate receptor signaling pathway|synaptic transmission|learning or memory|memory|protein localization|visual learning|response to wounding|sensory perception of pain|neurogenesis|sleep|directional locomotion|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|negative regulation of protein catabolic process|dopamine metabolic process|serotonin metabolic process|response to drug|positive regulation of apoptotic process|response to ethanol|regulation of synaptic plasticity|regulation of sensory perception of pain|regulation of excitatory postsynaptic membrane potential|calcium ion transmembrane transport|",N-methyl-D-aspartate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|calcium channel activity|protein binding|zinc ion binding|,10,-0.5,0.0983,10,0.7,0.404,0.2,0.0319,0.846,-4.3,6
ENSMUSG00000042594,SH2B3,SH2B adaptor protein 3,cytosol|,blood coagulation|cell differentiation|embryonic hemopoiesis|intracellular signal transduction|,signal transducer activity|protein binding|protein complex binding|phosphate ion binding|,10,0.1,0.00652,10,-0.4,0.393,-0.2,0.0317,0.847,-5.8,2.9
ENSMUSG00000042793,LGR6,leucine-rich repeat containing G protein-coupled receptor 6,integral component of plasma membrane|vesicle|trans-Golgi network membrane|,G-protein coupled receptor signaling pathway|Wnt signaling pathway|positive regulation of Wnt signaling pathway|positive regulation of cell migration|positive regulation of canonical Wnt signaling pathway|,transmembrane signaling receptor activity|protein binding|,0,0,0,1,-0.4,0.0341,-0.4,0.031,0.848,-2,1.8
ENSMUSG00000015243,ABCA1,"ATP-binding cassette, sub-family A (ABC1), member 1",Golgi apparatus|plasma membrane|plasma membrane|integral component of plasma membrane|cell surface|endocytic vesicle|membrane raft|phagocytic vesicle|perinuclear region of cytoplasm|,"peptide secretion|ATP catabolic process|protein lipidation|phagocytosis, engulfment|lysosome organization|G-protein coupled receptor signaling pathway|response to nutrient|cholesterol metabolic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|endosomal transport|positive regulation of cAMP biosynthetic process|intracellular cholesterol transport|regulation of Cdc42 protein signal transduction|cholesterol efflux|cholesterol efflux|phospholipid efflux|phospholipid efflux|high-density lipoprotein particle assembly|response to laminar fluid shear stress|apolipoprotein A-I-mediated signaling pathway|lipoprotein metabolic process|response to drug|cholesterol homeostasis|reverse cholesterol transport|cellular lipid metabolic process|small molecule metabolic process|phospholipid translocation|interleukin-1 beta secretion|phospholipid homeostasis|response to low-density lipoprotein particle|platelet dense granule organization|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to cholesterol|",receptor binding|protein binding|ATP binding|phospholipid binding|phospholipid transporter activity|anion transmembrane transporter activity|cholesterol binding|ATPase activity|cholesterol transporter activity|syntaxin binding|small GTPase binding|apolipoprotein binding|apolipoprotein A-I binding|apolipoprotein A-I receptor activity|ATPase binding|,10,0.6,0.453,10,-0.9,0.561,-0.2,0.0303,0.848,-3.6,3.4
ENSMUSG00000029712,ACTL6B,actin-like 6B,nucleus|nucleolus|SWI/SNF complex|SWI/SNF complex|nBAF complex|,"chromatin organization|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nervous system development|",transcription coactivator activity|structural constituent of cytoskeleton|,10,-0.2,0.0542,10,-0.7,0.0566,-0.2,0.03,0.849,-9.2,2
ENSMUSG00000041272,TOX,thymocyte selection-associated high mobility group box,nucleus|,None,DNA binding|,0,0,0,1,-0.4,0.033,-0.4,0.03,0.849,-2,1.8
ENSMUSG00000054364,RHOB,ras homolog family member B,nucleus|cytosol|plasma membrane|plasma membrane|endosome membrane|late endosome membrane|cleavage furrow|extracellular vesicular exosome|,cytokinesis|angiogenesis|GTP catabolic process|apoptotic process|transformed cell apoptotic process|cell adhesion|small GTPase mediated signal transduction|Rho protein signal transduction|axon guidance|blood coagulation|endosome to lysosome transport|protein transport|platelet activation|positive regulation of apoptotic process|positive regulation of angiogenesis|negative regulation of cell cycle|regulation of small GTPase mediated signal transduction|cellular response to hydrogen peroxide|cellular response to ionizing radiation|,GTPase activity|protein binding|GTP binding|GDP binding|,10,0,0,10,0.5,0.212,0.2,0.0299,0.849,-3.9,3
ENSMUSG00000039542,NCAM1,neural cell adhesion molecule 1,Golgi membrane|cytoplasm|plasma membrane|plasma membrane|external side of plasma membrane|cell surface|membrane|integral component of membrane|anchored component of membrane|extracellular vesicular exosome|,cell adhesion|axon guidance|cytokine-mediated signaling pathway|extracellular matrix organization|interferon-gamma-mediated signaling pathway|,identical protein binding|,10,0,0,10,0.4,0.15,0.1,0.0298,0.849,-7,4
ENSMUSG00000020661,DNMT3A,DNA (cytosine-5-)-methyltransferase 3 alpha,"chromosome, centromeric region|euchromatin|nucleus|nuclear heterochromatin|cytoplasm|nuclear matrix|",negative regulation of transcription from RNA polymerase II promoter|DNA methylation|methylation-dependent chromatin silencing|regulation of gene expression by genetic imprinting|spermatogenesis|DNA methylation on cytosine within a CG sequence|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|hypermethylation of CpG island|S-adenosylhomocysteine metabolic process|S-adenosylmethioninamine metabolic process|cellular response to amino acid stimulus|C-5 methylation of cytosine|C-5 methylation of cytosine|,"DNA binding|chromatin binding|DNA (cytosine-5-)-methyltransferase activity|protein binding|unmethylated CpG binding|metal ion binding|DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates|",10,4.3,0.0723,10,-0.7,0.0762,-0.1,0.0297,0.849,-3.8,7.8
ENSMUSG00000050974,GM9847,suppressor of cytokine signaling 2 pseudogene,None,None,None,4,0.8,0.251,4,0,0,0.1,0.0296,0.849,-2,3.4
ENSMUSG00000017167,CNTNAP1,contactin associated protein 1,integral component of plasma membrane|voltage-gated potassium channel complex|integral component of membrane|paranode region of axon|,protein localization to paranode region of axon|cytoskeleton organization|cell adhesion|signal transduction|axon guidance|axon cargo transport|positive regulation of signal transduction|neuronal action potential propagation|paranodal junction assembly|neuron projection morphogenesis|neuromuscular process controlling posture|neuromuscular process controlling balance|,receptor activity|SH3/SH2 adaptor activity|protein binding|SH3 domain binding|,0,0,0,1,0.3,0.0323,0.3,0.0294,0.849,-1.8,2
ENSMUSG00000026208,DES,desmin,cytosol|intermediate filament|fascia adherens|Z disc|neuromuscular junction|sarcolemma|,muscle contraction|cytoskeleton organization|regulation of heart contraction|muscle filament sliding|,structural constituent of cytoskeleton|protein binding|cytoskeletal protein binding|identical protein binding|,10,-0.4,0.132,10,0,0,-0.1,0.0292,0.849,-4.2,2
ENSMUSG00000021690,JMY,"junction mediating and regulatory protein, p53 cofactor",nucleus|cytoplasm|cytoskeleton|cell leading edge|,DNA repair|regulation of transcription from RNA polymerase II promoter|cell cycle arrest|Arp2/3 complex-mediated actin nucleation|positive regulation of apoptotic process|positive regulation of sequence-specific DNA binding transcription factor activity|'de novo' actin filament nucleation|actin polymerization-dependent cell motility|intrinsic apoptotic signaling pathway by p53 class mediator|,transcription coactivator activity|actin binding|protein binding|,10,0.4,0.0951,10,-0.1,0.00765,0.1,0.029,0.849,-7.3,4.2
ENSMUSG00000003190,BCL2L12,BCL2-like 12 (proline rich),nucleus|membrane|,positive regulation of transcription from RNA polymerase II promoter|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|,protein binding|,10,-4.3,1.89,10,0.3,0.172,-0.3,0.029,0.849,-7.7,2
ENSMUSG00000054428,ATPIF1,ATPase inhibitory factor 1,mitochondrion|mitochondrion|mitochondrial proton-transporting ATP synthase complex|cell surface|,angiogenesis|negative regulation of endothelial cell proliferation|generation of precursor metabolites and energy|heme biosynthetic process|erythrocyte differentiation|negative regulation of nucleotide metabolic process|protein homooligomerization|protein homotetramerization|negative regulation of hydrolase activity|negative regulation of hydrolase activity|reactive oxygen species metabolic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|,enzyme inhibitor activity|calmodulin binding|ATPase inhibitor activity|ATPase inhibitor activity|protein homodimerization activity|angiostatin binding|ATPase binding|ATPase binding|,0,0,0,1,0.3,0.0315,0.3,0.0286,0.85,-1.8,2
ENSMUSG00000033809,ALG3,"ALG3, alpha-1,3- mannosyltransferase",endoplasmic reticulum membrane|endoplasmic reticulum membrane|integral component of membrane|,protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|mannosylation|mannosylation|,"alpha-1,3-mannosyltransferase activity|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity|",0,0,0,1,0.3,0.0315,0.3,0.0286,0.85,-1.8,2
ENSMUSG00000019210,ATP6V1E1,"ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1","mitochondrion|lysosomal membrane|endosome|cytosol|cytosol|microvillus|apical plasma membrane|proton-transporting two-sector ATPase complex|proton-transporting two-sector ATPase complex, catalytic domain|extracellular vesicular exosome|",cellular iron ion homeostasis|metabolic process|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|proton transport|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|,"protein binding|hydrogen-exporting ATPase activity, phosphorylative mechanism|proton-transporting ATPase activity, rotational mechanism|ATPase binding|",10,-0.2,0.0494,10,0.1,0.00803,-0.1,0.0279,0.851,-3.5,2.2
ENSMUSG00000022220,ADCY4,adenylate cyclase 4,cytoplasm|plasma membrane|membrane|integral component of membrane|dendrite|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|protein binding|ATP binding|metal ion binding|,10,0,0,10,-0.5,0.418,-0.1,0.0279,0.851,-3.7,1.9
ENSMUSG00000000753,SERPINF1,"serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1",extracellular region|extracellular space|extracellular matrix|melanosome|extracellular vesicular exosome|,kidney development|multicellular organismal development|aging|short-term memory|cell proliferation|negative regulation of endopeptidase activity|negative regulation of angiogenesis|regulation of proteolysis|response to retinoic acid|negative regulation of inflammatory response|positive regulation of neurogenesis|response to glucocorticoid|negative regulation of epithelial cell proliferation involved in prostate gland development|,serine-type endopeptidase inhibitor activity|,1,-0.3,0.0405,1,-0.1,0.00121,-0.2,0.0277,0.851,-2,1.8
ENSMUSG00000024835,CORO1B,"coronin, actin binding protein, 1B",stress fiber|cytoplasm|actin filament|actin cytoskeleton|lamellipodium|cell leading edge|extracellular vesicular exosome|,cell migration|actin cytoskeleton organization|ruffle organization|negative regulation of Arp2/3 complex-mediated actin nucleation|endothelial cell chemotaxis|wound healing|actin filament bundle assembly|actin filament branching|protein localization to cell leading edge|positive regulation of lamellipodium morphogenesis|,protein binding|identical protein binding|actin filament binding|actin filament binding|Arp2/3 complex binding|,10,-0.9,0.53,10,0.1,0.00166,-0.3,0.0272,0.851,-5.1,3.3
ENSMUSG00000035686,THRSP,thyroid hormone responsive,nucleus|cytosol|,"transcription, DNA-templated|regulation of transcription, DNA-templated|lipid metabolic process|regulation of triglyceride biosynthetic process|regulation of lipid biosynthetic process|",protein homodimerization activity|,9,0,0,9,-0.4,0.111,-0.2,0.0272,0.851,-3.9,2.5
ENSMUSG00000062825,ACTG1,"actin, gamma 1",extracellular space|nucleus|cytosol|cytoskeleton|membrane|myofibril|filamentous actin|extracellular vesicular exosome|blood microparticle|,retina homeostasis|cellular component movement|axon guidance|cell junction assembly|adherens junction organization|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|sarcomere organization|cell-cell junction organization|membrane organization|,structural constituent of cytoskeleton|protein binding|ATP binding|identical protein binding|,10,-0.1,0.0191,10,-0.1,0.00947,-0.1,0.026,0.853,-3.6,2.7
ENSMUSG00000019772,VIP,vasoactive intestinal peptide,extracellular region|neuronal cell body|,positive regulation of endothelial cell proliferation|G-protein coupled receptor signaling pathway|body fluid secretion|learning or memory|positive regulation of cell proliferation|regulation of signal transduction|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|regulation of protein localization|negative regulation of apoptotic process|negative regulation of potassium ion transport|positive regulation of protein catabolic process|positive regulation of vasodilation|negative regulation of smooth muscle cell proliferation|regulation of sensory perception of pain|positive regulation of penile erection|,hormone activity|neuropeptide hormone activity|protein binding|,10,-3.1,1.53,10,0,0,-0.3,0.0259,0.853,-6.4,5.7
ENSMUSG00000044702,PALB2,partner and localizer of BRCA2,nucleus|nucleoplasm|,double-strand break repair via homologous recombination|somitogenesis|inner cell mass cell proliferation|DNA repair|mesoderm development|organ morphogenesis|post-anal tail morphogenesis|negative regulation of apoptotic process|,DNA binding|protein binding|,8,0.2,0.0627,10,-0.6,0.123,0.2,0.0252,0.853,-3.6,5.4
ENSMUSG00000032035,ETS1,v-ets avian erythroblastosis virus E26 oncogene homolog 1,nucleus|nucleus|nucleoplasm|transcription factor complex|cytoplasm|intercellular bridge|,"response to hypoxia|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|immune response|female pregnancy|positive regulation of cell proliferation|negative regulation of cell proliferation|response to mechanical stimulus|positive regulation of endothelial cell migration|regulation of extracellular matrix disassembly|hypothalamus development|pituitary gland development|PML body organization|response to estradiol|response to laminar fluid shear stress|regulation of apoptotic process|positive regulation of erythrocyte differentiation|regulation of angiogenesis|positive regulation of angiogenesis|negative regulation of cell cycle|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|cell motility|positive regulation of cellular component movement|angiogenesis involved in wound healing|estrous cycle phase|cellular response to hydrogen peroxide|response to interleukin-1|",sequence-specific DNA binding RNA polymerase II transcription factor activity|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|histone acetyltransferase binding|sequence-specific DNA binding|,10,-0.4,0.193,10,0.4,0.253,0.1,0.0248,0.854,-2,2.1
ENSMUSG00000025089,GFRA1,GDNF family receptor alpha 1,plasma membrane|extrinsic component of membrane|anchored component of membrane|extracellular vesicular exosome|,cell surface receptor signaling pathway|axon guidance|glial cell-derived neurotrophic factor receptor signaling pathway|,receptor binding|glial cell-derived neurotrophic factor receptor activity|,9,0,0,10,-0.5,0.166,-0.2,0.0243,0.855,-4.2,3.7
ENSMUSG00000031133,ARHGEF6,Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6,intracellular|cytosol|lamellipodium|,apoptotic process|JNK cascade|small GTPase mediated signal transduction|lamellipodium assembly|positive regulation of Rho GTPase activity|positive regulation of Rho GTPase activity|cell junction assembly|positive regulation of apoptotic process|positive regulation of GTPase activity|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|,10,1,0.531,10,0,0,0.4,0.0239,0.855,-6.4,3.6
ENSMUSG00000067338,TUBA3B,"tubulin, alpha 3B",nucleus|,biological_process|,molecular_function|,10,0,0,10,-0.4,0.0655,-0.1,0.022,0.857,-8,2
ENSMUSG00000022884,EIF4A2,eukaryotic translation initiation factor 4A2,cytosol|eukaryotic translation initiation factor 4F complex|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|ATP catabolic process|translation|translational initiation|regulation of translational initiation|gene expression|viral process|RNA metabolic process|mRNA metabolic process|cytokine-mediated signaling pathway|cellular protein metabolic process|",translation initiation factor activity|helicase activity|protein binding|ATP binding|ATP-dependent helicase activity|poly(A) RNA binding|,10,-1.7,0.114,10,0.5,0.331,0.1,0.022,0.857,-6.8,3.5
ENSMUSG00000038569,RAD9B,RAD9 homolog B (S. pombe),nucleoplasm|checkpoint clamp complex|,DNA damage checkpoint|DNA replication|DNA repair|,protein binding|,10,0.8,0.25,10,-0.8,0.276,0.1,0.0215,0.857,-2.9,4.1
ENSMUSG00000079418,ATG4A,"autophagy related 4A, cysteine peptidase",cytoplasm|,proteolysis|autophagy|protein transport|,cysteine-type peptidase activity|,10,0.3,0.13,10,-0.7,0.494,-0.2,0.0212,0.858,-3.5,2
ENSMUSG00000016206,H2-M3,"histocompatibility 2, M region locus 3",external side of plasma membrane|membrane|MHC class Ib protein complex|,"positive regulation of T cell mediated cytotoxicity|positive regulation of T cell mediated cytotoxicity|response to molecule of bacterial origin|alpha-beta T cell activation involved in immune response|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|positive regulation of T cell tolerance induction|immune response-inhibiting cell surface receptor signaling pathway|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|negative regulation of T cell proliferation|defense response to bacterium|defense response to bacterium|positive regulation of nitric oxide biosynthetic process|positive regulation of regulatory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity|negative regulation of dendritic cell differentiation|",receptor binding|peptide antigen binding|peptide antigen binding|,10,-1.4,0.617,10,0.6,0.491,0.2,0.0209,0.858,-7.8,4.7
ENSMUSG00000027490,E2F1,E2F transcription factor 1,nucleus|nucleoplasm|cytoplasm|Rb-E2F complex|,"DNA damage checkpoint|mitotic G1 phase|G1/S transition of mitotic cell cycle|mitotic G2 phase|negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|Notch signaling pathway|spermatogenesis|cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of gene expression|forebrain development|anoikis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|mRNA stabilization|cellular response to fatty acid|cellular response to hypoxia|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|lens fiber cell apoptotic process|regulation of G1/S transition of mitotic cell cycle|",core promoter binding|DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|transcription factor binding|sequence-specific DNA binding|,10,-0.1,0.000716,10,-0.2,0.0256,-0.1,0.0208,0.858,-8.7,3
ENSMUSG00000018899,IRF1,interferon regulatory factor 1,nuclear chromatin|nucleus|nucleoplasm|cytoplasm|cytosol|,"regulation of adaptive immune response|transcription from RNA polymerase II promoter|apoptotic process|cell cycle arrest|blood coagulation|negative regulation of cell proliferation|cytokine-mediated signaling pathway|positive regulation of type I interferon production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|cellular response to interferon-beta|CD8-positive, alpha-beta T cell differentiation|positive regulation of interleukin-12 biosynthetic process|regulation of innate immune response|negative regulation of regulatory T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|regulation of cell cycle|interferon-gamma-mediated signaling pathway|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|cellular response to mechanical stimulus|regulation of CD8-positive, alpha-beta T cell proliferation|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|,7,-3.4,1.64,7,3.7,1.24,-0.1,0.0206,0.858,-9.2,7.2
ENSMUSG00000030047,ARHGAP25,Rho GTPase activating protein 25,cytosol|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,10,5.9,2.56,10,0.1,0.00661,0.1,0.0204,0.858,-2.5,13
ENSMUSG00000073910,MOB3B,MOB kinase activator 3B,None,None,protein binding|metal ion binding|,10,-0.3,0.0858,10,0.1,0.0165,-0.1,0.0202,0.859,-3.5,3.5
ENSMUSG00000021919,CHAT,choline O-acetyltransferase,nucleus|cytoplasm|mitochondrion|cytosol|axon|neuronal cell body|,phospholipid metabolic process|phosphatidylcholine biosynthetic process|synaptic transmission|neurotransmitter secretion|neuromuscular synaptic transmission|muscle organ development|establishment of synaptic specificity at neuromuscular junction|rhythmic behavior|adult walking behavior|dendrite development|neurotransmitter biosynthetic process|rhythmic excitation|small molecule metabolic process|glycerophospholipid biosynthetic process|,choline O-acetyltransferase activity|,10,0.3,0.218,10,0,0,0.1,0.0202,0.859,-2.9,3.4
ENSMUSG00000022577,LY6H,"lymphocyte antigen 6 complex, locus H",plasma membrane|anchored component of membrane|,nervous system development|organ morphogenesis|,None,10,0.4,0.207,10,0,0,0.1,0.02,0.859,-6.2,7.8
ENSMUSG00000040040,IFT88,intraflagellar transport 88,centriole|cilium|cilium|axoneme|intraciliary transport particle B|motile primary cilium|motile cilium|photoreceptor connecting cilium|ciliary basal body|apical part of cell|,eye development|in utero embryonic development|epithelial cell morphogenesis|smoothened signaling pathway|determination of left/right symmetry|protein localization|anterior/posterior pattern specification|protein processing|spinal cord dorsal/ventral patterning|telencephalon development|regulation of odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|positive regulation of proteolysis|embryonic organ development|forebrain morphogenesis|palate development|cilium morphogenesis|cardiac septum morphogenesis|lung vasculature development|regulation of cilium assembly|regulation of autophagic vacuole assembly|,None,10,-0.7,0.6,10,0,0,-0.1,0.0199,0.859,-7.9,3
ENSMUSG00000049721,GAL3ST1,galactose-3-O-sulfotransferase 1,Golgi membrane|integral component of plasma membrane|membrane|,protein N-linked glycosylation|sphingolipid metabolic process|galactosylceramide biosynthetic process|glycosphingolipid metabolic process|spermatogenesis|myelination|small molecule metabolic process|,galactosylceramide sulfotransferase activity|sulfotransferase activity|,10,-1,0.555,10,0.7,0.555,-0.2,0.0195,0.859,-8.1,5.7
ENSMUSG00000022663,ATG3,autophagy related 3,cytoplasmic ubiquitin ligase complex|cytosol|,autophagic vacuole assembly|autophagic vacuole assembly|mitochondrion degradation|cellular protein modification process|protein targeting to membrane|protein ubiquitination|mitochondrial fragmentation involved in apoptotic process|nucleophagy|regulation of cilium assembly|,protein binding|Atg8 ligase activity|Atg8 ligase activity|Atg12 ligase activity|small conjugating protein ligase activity|enzyme binding|,10,0.6,0.296,10,-0.9,0.446,0.1,0.0193,0.86,-5.2,3.4
ENSMUSG00000041607,MBP,myelin basic protein,nucleus|plasma membrane|internode region of axon|neuronal cell body|compact myelin|,immune response|synaptic transmission|central nervous system development|axon ensheathment|response to toxic substance|substantia nigra development|myelination|negative regulation of axonogenesis|membrane organization|,protease binding|protein binding|structural constituent of myelin sheath|,10,0,0,10,0.4,0.412,0.1,0.0188,0.86,-1.8,3.1
ENSMUSG00000029638,GLCCI1,glucocorticoid induced transcript 1,cytoplasm|,None,None,10,0,0,10,-0.8,0.381,-0.1,0.0188,0.86,-4,2.3
ENSMUSG00000004771,RAB11A,"RAB11A, member RAS oncogene family",mitochondrion|trans-Golgi network|plasma membrane|transport vesicle|axon|cytoplasmic vesicle membrane|phagocytic vesicle membrane|cleavage furrow|protein complex|phagocytic vesicle|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|extracellular vesicular exosome|,cytokinesis|GTP catabolic process|water transport|small GTPase mediated signal transduction|protein transport|vesicle-mediated transport|neuron projection development|melanosome transport|positive regulation of axon extension|regulation of long-term neuronal synaptic plasticity|plasma membrane to endosome transport|regulation of protein transport|transmembrane transport|protein localization to plasma membrane|,GTPase activity|protein binding|GTP binding|syntaxin binding|,9,0,0,8,-0.3,0.151,-0.1,0.0187,0.86,-3.9,2.7
ENSMUSG00000026185,IGFBP5,insulin-like growth factor binding protein 5,extracellular region|extracellular region|insulin-like growth factor binding protein complex|,regulation of cell growth|osteoblast differentiation|glucose metabolic process|signal transduction|regulation of glucose metabolic process|negative regulation of smooth muscle cell migration|negative regulation of translation|negative regulation of cell migration|hair follicle morphogenesis|intracellular signal transduction|glucose homeostasis|positive regulation of insulin-like growth factor receptor signaling pathway|negative regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|type B pancreatic cell proliferation|negative regulation of osteoblast differentiation|skeletal muscle tissue growth|negative regulation of smooth muscle cell proliferation|striated muscle cell differentiation|positive regulation of protein kinase B signaling|mammary gland involution|cellular response to cAMP|cellular response to organic cyclic compound|,fibronectin binding|protein binding|insulin-like growth factor I binding|,10,0.2,0.0244,10,0,0,0.1,0.0183,0.861,-7.3,4.6
ENSMUSG00000089984,FBXO24,F-box protein 24,ubiquitin ligase complex|,protein ubiquitination|,ubiquitin-protein transferase activity|,10,0,0,10,0.1,0.0201,0.1,0.0174,0.862,-8.9,3
ENSMUSG00000021192,GOLGA5,golgin A5,Golgi membrane|Golgi apparatus|cis-Golgi network|membrane|integral component of membrane|Golgi cisterna|,Golgi organization|Golgi vesicle transport|,Rab GTPase binding|protein homodimerization activity|,10,-0.6,0.497,10,0.5,0.17,-0.1,0.0173,0.862,-3,4.1
ENSMUSG00000046020,POFUT1,protein O-fucosyltransferase 1,endoplasmic reticulum|membrane|,"angiogenesis|somitogenesis|fucose metabolic process|regulation of transcription, DNA-templated|protein O-linked glycosylation|Notch signaling pathway|Notch signaling pathway|nervous system development|heart development|embryo development|O-glycan processing|protein O-linked fucosylation|",fucosyltransferase activity|peptide-O-fucosyltransferase activity|peptide-O-fucosyltransferase activity|,10,-1.6,0.241,10,0.3,0.0594,0.1,0.0173,0.862,-4.7,6.4
ENSMUSG00000031446,CUL4A,cullin 4A,Cul4A-RING E3 ubiquitin ligase complex|Cul4-RING E3 ubiquitin ligase complex|,G1/S transition of mitotic cell cycle|DNA repair|ubiquitin-dependent protein catabolic process|cell cycle arrest|negative regulation of cell proliferation|viral process|protein ubiquitination|regulation of protein metabolic process|intrinsic apoptotic signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|,protein binding|ubiquitin protein ligase binding|,10,0.1,0.0164,10,0.1,0.00211,0.1,0.0169,0.862,-2.5,3.1
ENSMUSG00000008136,FHL2,four and a half LIM domains 2,nucleus|nucleoplasm|focal adhesion|actin cytoskeleton|Z disc|M band|,"negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-templated|response to hormone|androgen receptor signaling pathway|negative regulation of apoptotic process|cellular lipid metabolic process|small molecule metabolic process|positive regulation of transcription, DNA-templated|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|heart trabecula formation|",transcription coactivator activity|protein binding|transcription factor binding|zinc ion binding|identical protein binding|androgen receptor binding|,10,0.4,0.367,10,0,0,0.1,0.0168,0.863,-3.7,4.3
ENSMUSG00000021338,LRRC16A,leucine rich repeat containing 16A,nucleus|cytoplasm|cytosol|lamellipodium|filamentous actin|extracellular vesicular exosome|,actin filament organization|blood coagulation|cell migration|lamellipodium assembly|positive regulation of cell migration|positive regulation of actin filament polymerization|ruffle organization|urate metabolic process|positive regulation of stress fiber assembly|barbed-end actin filament uncapping|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping|,protein complex binding|,10,-0.1,0.00739,10,-0.5,0.0884,-0.1,0.0157,0.864,-4.6,4.1
ENSMUSG00000069581,TSPEAR,thrombospondin-type laminin G domain and EAR repeats,extracellular region|cell surface|stereocilium|ciliary membrane|,sensory perception of sound|,molecular_function|,10,3.3,0.836,10,-0.3,0.122,-0.1,0.0155,0.864,-3.2,7.2
ENSMUSG00000029714,GIGYF1,GRB10 interacting GYF protein 1,None,insulin-like growth factor receptor signaling pathway|,None,10,-0.1,0.0206,10,0,0,-0.1,0.0155,0.864,-4.5,2.7
ENSMUSG00000021423,LY86,lymphocyte antigen 86,extracellular space|plasma membrane|,apoptotic process|inflammatory response|humoral immune response|cell proliferation|positive regulation of lipopolysaccharide-mediated signaling pathway|innate immune response|,None,10,-0.4,0.134,10,0,0,-0.2,0.0155,0.864,-9.8,3
ENSMUSG00000031503,COL4A2,"collagen, type IV, alpha 2",extracellular region|collagen type IV trimer|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|extracellular matrix|intracellular membrane-bounded organelle|extracellular vesicular exosome|,"angiogenesis|transcription, DNA-templated|axon guidance|negative regulation of angiogenesis|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix organization|collagen catabolic process|cellular response to transforming growth factor beta stimulus|",extracellular matrix structural constituent|protein binding|,10,-0.7,0.183,10,0,0,-0.2,0.0153,0.865,-3,1.7
ENSMUSG00000003541,IER3,immediate early response 3,nucleus|integral component of membrane|,response to protozoan|negative regulation of systemic arterial blood pressure|regulation of DNA repair|apoptotic process|mitotic G2 DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage|anatomical structure morphogenesis|negative regulation of apoptotic process|positive regulation of protein catabolic process|negative regulation of glycolytic process|regulation of nucleocytoplasmic transport|negative regulation of inflammatory response|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of reactive oxygen species metabolic process|regulation of response to DNA damage stimulus|,protein binding|,10,0,0,10,-0.9,0.143,-0.3,0.0147,0.865,-4.8,1.7
ENSMUSG00000035842,DDX11,DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11,nuclear chromatin|spindle pole|nucleus|nucleus|nucleoplasm|midbody|,mitotic sister chromatid segregation|mitotic S phase|G2/M transition of mitotic cell cycle|ATP catabolic process|ATP catabolic process|activation of signaling protein activity involved in unfolded protein response|sister chromatid cohesion|positive regulation of cell proliferation|viral process|endoplasmic reticulum unfolded protein response|DNA duplex unwinding|DNA duplex unwinding|cellular protein metabolic process|,"DNA binding|DNA helicase activity|RNA binding|ATP-dependent DNA helicase activity|helicase activity|protein binding|ATP binding|DNA-dependent ATPase activity|metal ion binding|4 iron, 4 sulfur cluster binding|",10,-0.1,0.00777,10,-0.2,0.0092,-0.1,0.0144,0.866,-4.1,3.7
ENSMUSG00000000282,MNT,MAX network transcriptional repressor,nucleus|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|multicellular organismal development|cell aging|negative regulation of cell proliferation|regulation of cell cycle|negative regulation of apoptotic signaling pathway|,RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|protein dimerization activity|,10,-0.1,0.00128,10,-0.2,0.0155,-0.2,0.0144,0.866,-5.8,2.8
ENSMUSG00000074934,GREM1,"gremlin 1, DAN family BMP antagonist",extracellular space|cell surface|,"cell morphogenesis|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|apoptotic process|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|cell-cell signaling|positive regulation of cell proliferation|proximal/distal pattern formation|regulation of epithelial to mesenchymal transition|collagen fibril organization|negative regulation of cell growth|embryonic limb morphogenesis|negative regulation of bone mineralization|negative regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoblast proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of bone remodeling|determination of dorsal identity|positive regulation of NF-kappaB transcription factor activity|regulation of focal adhesion assembly|positive regulation of telomerase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|ureteric bud formation|positive regulation of protein tyrosine kinase activity|negative regulation of monocyte chemotaxis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of osteoclast proliferation|positive regulation of peptidyl-tyrosine autophosphorylation|negative regulation of bone trabecula formation|negative regulation of bone mineralization involved in bone maturation|positive regulation of receptor activity|positive regulation of cardiac muscle cell differentiation|",cytokine activity|protein binding|morphogen activity|transmembrane receptor protein tyrosine kinase activator activity|BMP binding|vascular endothelial growth factor receptor 2 binding|receptor agonist activity|,10,0,0,10,-0.2,0.0354,-0.1,0.0143,0.866,-7,2.6
ENSMUSG00000015120,UBE2I,ubiquitin-conjugating enzyme E2I,synaptonemal complex|fibrillar center|nucleus|nucleoplasm|cytoplasm|PML body|dendrite|synapse|,"negative regulation of transcription from RNA polymerase II promoter|cellular protein modification process|ubiquitin-dependent protein catabolic process|chromosome segregation|mitotic nuclear division|regulation of receptor activity|viral process|protein ubiquitination|protein sumoylation|protein sumoylation|protein sumoylation|positive regulation of intracellular steroid hormone receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|cellular protein metabolic process|negative regulation of transcription, DNA-templated|positive regulation of sequence-specific DNA binding transcription factor activity|",ubiquitin-protein transferase activity|protein binding|ATP binding|protein C-terminus binding|transcription factor binding|SUMO ligase activity|enzyme binding|HLH domain binding|bHLH transcription factor binding|poly(A) RNA binding|RING-like zinc finger domain binding|,8,0,0,8,-0.4,0.146,-0.1,0.0141,0.866,-7.8,2
ENSMUSG00000022508,BCL6,B-cell CLL/lymphoma 6,nucleus|replication fork|,"protein import into nucleus, translocation|negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|negative regulation of cell-matrix adhesion|germinal center formation|regulation of germinal center formation|negative regulation of type 2 immune response|negative regulation of B cell apoptotic process|transcription, DNA-templated|inflammatory response|cellular response to DNA damage stimulus|Rho protein signal transduction|spermatogenesis|negative regulation of cell proliferation|actin cytoskeleton organization|B cell differentiation|negative regulation of cell growth|positive regulation of B cell proliferation|regulation of Rho GTPase activity|negative regulation of mast cell cytokine production|negative regulation of Rho protein signal transduction|type 2 immune response|positive regulation of apoptotic process|regulation of memory T cell differentiation|negative regulation of T-helper 2 cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|negative regulation of isotype switching to IgE isotypes|erythrocyte development|regulation of inflammatory response|regulation of immune response|positive regulation of cellular component movement|",chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|chromatin DNA binding|sequence-specific DNA binding|metal ion binding|,10,3.4,1.07,10,0,0,0.2,0.0141,0.866,-2.7,7.7
ENSMUSG00000038546,RANBP9,RAN binding protein 9,nucleus|cytosol|microtubule associated complex|,protein complex assembly|microtubule nucleation|axon guidance|,protein binding|Ran GTPase binding|enzyme binding|,10,-0.4,0.141,10,0.9,0.686,0.1,0.0141,0.866,-4.1,8.7
ENSMUSG00000005057,SH2B2,SH2B adaptor protein 2,cytoplasm|cytosol|plasma membrane|,signal transduction|blood coagulation|insulin receptor signaling pathway|positive regulation of signal transduction|intracellular signal transduction|regulation of JAK-STAT cascade|,signal transducer activity|SH3/SH2 adaptor activity|protein binding|JAK pathway signal transduction adaptor activity|,10,-0.3,0.0562,10,0,0,-0.1,0.014,0.866,-2.8,2
ENSMUSG00000079465,COL4A3,"collagen, type IV, alpha 3 (Goodpasture antigen)",extracellular region|collagen type IV trimer|basement membrane|endoplasmic reticulum lumen|,activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|cell surface receptor signaling pathway|axon guidance|sensory perception of sound|blood circulation|cell proliferation|negative regulation of cell proliferation|response to glucose|negative regulation of endopeptidase activity|negative regulation of angiogenesis|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|glomerular basement membrane development|endothelial cell apoptotic process|,integrin binding|integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|metalloendopeptidase inhibitor activity|,10,-5.3,1.02,10,0,0,-0.1,0.0138,0.866,-10.3,3.5
ENSMUSG00000028163,NFKB1,nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|I-kappaB/NF-kappaB complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|negative regulation of cytokine production|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription from RNA polymerase II promoter|apoptotic process|inflammatory response|response to oxidative stress|positive regulation of macrophage derived foam cell differentiation|positive regulation of lipid storage|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|membrane protein intracellular domain proteolysis|negative regulation of cellular protein metabolic process|negative regulation of cholesterol transport|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of apoptotic process|negative regulation of interleukin-12 biosynthetic process|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|response to copper ion|neurotrophin TRK receptor signaling pathway|negative regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to peptide hormone stimulus|positive regulation of canonical Wnt signaling pathway|positive regulation of hyaluronan biosynthetic process|positive regulation of miRNA metabolic process|",regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|nucleic acid binding transcription factor activity|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|heat shock protein binding|protein homodimerization activity|transcription regulatory region DNA binding|,10,-0.6,0.236,10,0,0,-0.1,0.0138,0.866,-4.5,2.5
ENSMUSG00000020954,STRN3,"striatin, calmodulin binding protein 3",protein phosphatase type 2A complex|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|dendrite|neuronal cell body|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|response to estradiol|negative regulation of intracellular estrogen receptor signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|",sequence-specific DNA binding transcription factor activity|protein binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|armadillo repeat domain binding|,10,0.3,0.101,10,0,0,0.1,0.0137,0.867,-2,3.6
ENSMUSG00000036768,KIF15,kinesin family member 15,centrosome|spindle|cytosol|plus-end kinesin complex|microtubule|membrane|,microtubule-based movement|mitotic nuclear division|blood coagulation|metabolic process|metabolic process|cell proliferation|antigen processing and presentation of exogenous peptide antigen via MHC class II|,DNA binding|motor activity|microtubule motor activity|ATP binding|microtubule binding|,10,0,0,10,0.2,0.0296,0.1,0.0135,0.867,-7.9,3.8
ENSMUSG00000037347,CHST7,carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7,Golgi membrane|integral component of membrane|integral component of membrane|,carbohydrate metabolic process|polysaccharide metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|,N-acetylglucosamine 6-O-sulfotransferase activity|chondroitin 6-sulfotransferase activity|,10,0.1,0.00487,10,0.2,0.0112,0.1,0.0135,0.867,-3.1,2.5
ENSMUSG00000020108,DDIT4,DNA-damage-inducible transcript 4,intracellular|cytoplasm|mitochondrion|cytosol|,response to hypoxia|neuron migration|brain development|cell proliferation|negative regulation of peptidyl-threonine phosphorylation|neuron differentiation|negative regulation of TOR signaling|negative regulation of peptidyl-serine phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein complex disassembly|negative regulation of glycolytic process|neurotrophin TRK receptor signaling pathway|defense response to virus|reactive oxygen species metabolic process|positive regulation of neuron death|negative regulation of intracellular signal transduction|,14-3-3 protein binding|,10,0.2,0.0479,10,-0.1,0.0131,0.1,0.0128,0.868,-2.9,2.7
ENSMUSG00000048878,HEXIM1,hexamethylene bis-acetamide inducible 1,nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|heart development|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|",cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|snRNA binding|,0,0,0,1,-0.2,0.0139,-0.2,0.0126,0.868,-2,1.8
ENSMUSG00000019768,ESR1,estrogen receptor 1,nucleus|nucleoplasm|Golgi apparatus|plasma membrane|membrane|integral component of membrane|,"antral ovarian follicle growth|epithelial cell development|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|signal transduction|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|androgen metabolic process|male gonad development|gene expression|negative regulation of gene expression|positive regulation of phospholipase C activity|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|response to estradiol|regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|steroid hormone mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|response to estrogen|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of nitric-oxide synthase activity|positive regulation of sequence-specific DNA binding transcription factor activity|uterus development|vagina development|prostate epithelial cord elongation|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|regulation of branching involved in prostate gland morphogenesis|mammary gland branching involved in pregnancy|mammary gland alveolus development|epithelial cell proliferation involved in mammary gland duct elongation|cellular response to estradiol stimulus|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid binding|protein binding|beta-catenin binding|transcription factor binding|zinc ion binding|enzyme binding|nitric-oxide synthase regulator activity|estrogen receptor activity|estrogen response element binding|estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|identical protein binding|,10,-0.9,0.335,10,0.3,0.0727,-0.1,0.0122,0.868,-5.5,3.1
ENSMUSG00000000486,1-Sep,septin 1,microtubule organizing center|midbody|septin complex|,cell cycle|cell division|,protein binding|GTP binding|,10,4.2,0.155,10,-0.7,0.502,-0.3,0.0116,0.869,-4.9,8.3
ENSMUSG00000026637,TRAF5,TNF receptor-associated factor 5,cytoplasm|centrosome|cytosol|cytoplasmic side of plasma membrane|CD40 receptor complex|,apoptotic process|signal transduction|positive regulation of cell proliferation|protein ubiquitination|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|,ubiquitin-protein transferase activity|signal transducer activity|protein binding|zinc ion binding|ubiquitin protein ligase binding|thioesterase binding|,9,0,0,10,0.3,0.141,0.1,0.0114,0.869,-5.5,3.5
ENSMUSG00000036779,PAPD5,PAP associated domain containing 5,cellular_component|nucleolus|cytoplasm|,DNA-dependent DNA replication|rRNA processing|mRNA processing|mitotic nuclear division|histone mRNA catabolic process|,DNA binding|DNA-directed DNA polymerase activity|polynucleotide adenylyltransferase activity|poly(A) RNA binding|metal ion binding|,10,-0.6,0.398,10,0,0,0.1,0.0113,0.869,-6,3.5
ENSMUSG00000031162,GATA1,GATA binding protein 1 (globin transcription factor 1),nucleus|nucleoplasm|transcription factor complex|transcriptional repressor complex|,negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|transcription from RNA polymerase II promoter|cell-cell signaling|blood coagulation|negative regulation of cell proliferation|male gonad development|regulation of glycoprotein biosynthetic process|regulation of definitive erythrocyte differentiation|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|basophil differentiation|eosinophil differentiation|negative regulation of bone mineralization|positive regulation of osteoblast proliferation|embryonic hemopoiesis|eosinophil fate commitment|negative regulation of apoptotic process|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|erythrocyte development|positive regulation of peptidyl-tyrosine phosphorylation|platelet aggregation|transcriptional activation by promoter-enhancer looping|dendritic cell differentiation|cellular response to thyroid hormone stimulus|negative regulation of transcription regulatory region DNA binding|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,"transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcription factor binding|enhancer sequence-specific DNA binding|p53 binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|zinc ion binding|DNA binding, bending|chromatin DNA binding|sequence-specific DNA binding|C2H2 zinc finger domain binding|",10,0,0,10,0.2,0.0316,0.1,0.0106,0.87,-7.1,6.9
ENSMUSG00000029819,NPY,neuropeptide Y,extracellular region|extracellular space|cell|,"calcium ion transport|cellular component movement|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|neuropeptide signaling pathway|synaptic transmission|digestion|behavior|feeding behavior|blood circulation|regulation of blood pressure|cell proliferation|adult feeding behavior|central nervous system neuron development|cerebral cortex development|neuron projection development|positive regulation of appetite|",G-protein coupled receptor binding|G-protein coupled receptor activity|receptor binding|neuropeptide hormone activity|calcium channel regulator activity|,10,0,0,10,-1,0.834,-0.5,0.0106,0.87,-5.1,3.7
ENSMUSG00000047497,ADAMTS12,"ADAM metallopeptidase with thrombospondin type 1 motif, 12",proteinaceous extracellular matrix|extracellular matrix|,cell-matrix adhesion|cell migration|proteoglycan catabolic process|negative regulation of chondrocyte differentiation|regulation of inflammatory response|proteolysis involved in cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus|regulation of endothelial tube morphogenesis|negative regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to hepatocyte growth factor stimulus|,metalloendopeptidase activity|protein binding|zinc ion binding|,10,0,0,10,0.1,0.0404,0.1,0.01,0.871,-2.7,2
ENSMUSG00000024429,GNL1,guanine nucleotide binding protein-like 1,extracellular space|nucleus|cytosol|,T cell mediated immunity|GTP catabolic process|cellular response to DNA damage stimulus|signal transduction|ribosome biogenesis|,GTPase activity|structural molecule activity|GTP binding|,10,-0.1,0.0197,10,0,0,-0.1,0.00995,0.871,-2.5,1.7
ENSMUSG00000096199,PTRHD1,peptidyl-tRNA hydrolase domain containing 1,extracellular vesicular exosome|,peptidyl-tyrosine dephosphorylation|,aminoacyl-tRNA hydrolase activity|protein tyrosine phosphatase activity|,0,0,0,1,-0.2,0.0108,-0.2,0.00978,0.871,-2,1.8
ENSMUSG00000003545,FOSB,FBJ murine osteosarcoma viral oncogene homolog B,nucleus|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|female pregnancy|response to mechanical stimulus|response to progesterone|cellular response to hormone stimulus|response to drug|response to morphine|response to corticosterone|response to cAMP|cellular response to calcium ion|,DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|sequence-specific DNA binding|,10,0.4,0.239,10,-1.3,0.177,0.1,0.0097,0.871,-5.9,3.4
ENSMUSG00000032079,APOA5,apolipoprotein A-V,extracellular region|extracellular region|extracellular space|very-low-density lipoprotein particle|high-density lipoprotein particle|chylomicron|,triglyceride metabolic process|triglyceride metabolic process|lipid transport|response to hormone|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|triglyceride catabolic process|organ regeneration|triglyceride-rich lipoprotein particle remodeling|lipoprotein metabolic process|tissue regeneration|cholesterol homeostasis|cellular lipid metabolic process|small molecule metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of receptor-mediated endocytosis|positive regulation of lipid catabolic process|positive regulation of lipoprotein lipase activity|acylglycerol homeostasis|acylglycerol homeostasis|triglyceride homeostasis|triglyceride homeostasis|,phospholipid binding|enzyme activator activity|heparin binding|heparin binding|lipid binding|enzyme binding|phosphatidylcholine binding|lipase binding|low-density lipoprotein particle receptor binding|lipase activator activity|lipoprotein lipase activator activity|lipoprotein particle receptor binding|,1,0.2,0.0105,0,0,0,0.2,0.00959,0.872,-1.8,2
ENSMUSG00000001755,COASY,CoA synthase,nucleus|cytoplasm|mitochondrial outer membrane|mitochondrial matrix|extracellular vesicular exosome|,vitamin metabolic process|water-soluble vitamin metabolic process|cell death|coenzyme biosynthetic process|coenzyme A biosynthetic process|coenzyme A biosynthetic process|coenzyme A biosynthetic process|pantothenate metabolic process|phosphorylation|small molecule metabolic process|,dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity|protein binding|ATP binding|,10,0,0,10,-0.2,0.0452,-0.1,0.00955,0.872,-6.1,4.1
ENSMUSG00000026826,NR4A2,"nuclear receptor subfamily 4, group A, member 2",nucleus|nucleoplasm|cytoplasm|,"response to hypoxia|neuron migration|response to amphetamine|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|signal transduction|adult locomotory behavior|post-embryonic development|response to inorganic substance|gene expression|death|response to insecticide|central nervous system projection neuron axonogenesis|habenula development|intracellular receptor signaling pathway|intracellular receptor signaling pathway|cellular response to extracellular stimulus|cellular response to oxidative stress|regulation of dopamine metabolic process|dopamine biosynthetic process|neuron maturation|positive regulation of catalytic activity|steroid hormone mediated signaling pathway|negative regulation of neuron apoptotic process|regulation of respiratory gaseous exchange|positive regulation of transcription from RNA polymerase II promoter|general adaptation syndrome|dopaminergic neuron differentiation|",steroid hormone receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|protein heterodimerization activity|,10,0.1,0.0233,10,0,0,0.1,0.00954,0.872,-6,3.8
ENSMUSG00000020458,RTN4,reticulon 4,intracellular|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum|plasma membrane|integral component of endoplasmic reticulum membrane|cell projection|neuronal cell body|extracellular vesicular exosome|,angiogenesis|apoptotic process|axonal fasciculation|cerebral cortex radial glia guided migration|negative regulation of cell growth|regulation of cell migration|negative regulation of axon extension|regulation of apoptotic process|neurotrophin TRK receptor signaling pathway|regulation of axonogenesis|negative regulation of axonogenesis|cardiac epithelial to mesenchymal transition|endoplasmic reticulum tubular network organization|regulation of branching morphogenesis of a nerve|,protein binding|poly(A) RNA binding|,10,0,0,10,0.6,0.496,0.1,0.00949,0.872,-2.7,2.9
ENSMUSG00000029723,TSC22D4,"TSC22 domain family, member 4",nucleus|cytoplasm|,"transcription, DNA-templated|response to osmotic stress|negative regulation of transcription, DNA-templated|",sequence-specific DNA binding transcription factor activity|protein binding|,10,-1.1,0.394,10,0,0,-0.2,0.00941,0.872,-3.5,2.1
ENSMUSG00000024096,RALBP1,ralA binding protein 1,cytosol|membrane|,ATP catabolic process|transport|chemotaxis|signal transduction|small GTPase mediated signal transduction|small GTPase mediated signal transduction|positive regulation of Rac GTPase activity|positive regulation of Rac GTPase activity|regulation of GTPase activity|positive regulation of Cdc42 GTPase activity|regulation of small GTPase mediated signal transduction|,"GTPase activator activity|protein binding|ATPase activity|Ral GTPase binding|Rac GTPase activator activity|ATPase activity, coupled to movement of substances|Rac GTPase binding|",10,0,0,10,-5.5,1.33,-0.1,0.00927,0.872,-10.1,1.8
ENSMUSG00000060639,HIST1H4I,"histone cluster 1, H4i",None,None,None,2,0.1,0.0101,0,0,0,0.1,0.00919,0.872,-1.8,2
ENSMUSG00000039983,CCDC32,coiled-coil domain containing 32,cellular_component|,biological_process|,molecular_function|,10,0.3,0.092,10,-1.4,0.515,0.1,0.00882,0.873,-5.3,4.2
ENSMUSG00000024959,BAD,BCL2-associated agonist of cell death,mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane|cytosol|cytosol|,release of cytochrome c from mitochondria|glucose catabolic process|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|response to glucose|positive regulation of autophagy|positive regulation of mitochondrial membrane potential|suppression by virus of host apoptotic process|cytokine-mediated signaling pathway|positive regulation of insulin secretion|response to estradiol|response to progesterone|positive regulation of glucokinase activity|response to testosterone|response to oleic acid|positive regulation of insulin secretion involved in cellular response to glucose stimulus|Fc-epsilon receptor signaling pathway|response to drug|response to hydrogen peroxide|glucose homeostasis|positive regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of apoptotic process|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|type B pancreatic cell proliferation|innate immune response|response to ethanol|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of proteolysis|ADP metabolic process|ATP metabolic process|regulation of mitochondrial membrane permeability|pore complex assembly|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of epithelial cell proliferation|response to glucocorticoid|response to calcium ion|positive regulation of apoptotic process by virus|cellular process regulating host cell cycle in response to virus|cellular response to chromate|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to lipid|cellular response to hypoxia|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|positive regulation of type B pancreatic cell development|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|phospholipid binding|lipid binding|cysteine-type endopeptidase activator activity involved in apoptotic process|protein kinase binding|protein phosphatase 2B binding|protein kinase B binding|protein heterodimerization activity|,10,0.7,0.34,10,0,0,0.1,0.00871,0.873,-2.6,3.8
ENSMUSG00000028917,PLEKHM2,"pleckstrin homology domain containing, family M (with RUN domain) member 2",cytoplasm|,Golgi organization|,protein binding|kinesin binding|,10,0,0,10,-0.6,0.56,-0.1,0.00861,0.873,-3.7,2.6
ENSMUSG00000014850,MSH3,mutS homolog 3,nuclear chromosome|nucleus|membrane|MutSbeta complex|,meiotic mismatch repair|ATP catabolic process|DNA repair|mismatch repair|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments|maintenance of DNA repeat elements|negative regulation of DNA recombination|positive regulation of helicase activity|,Y-form DNA binding|heteroduplex DNA loop binding|double-strand/single-strand DNA junction binding|single-stranded DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|centromeric DNA binding|enzyme binding|mismatched DNA binding|dinucleotide insertion or deletion binding|single guanine insertion binding|dinucleotide repeat insertion binding|oxidized purine DNA binding|,9,-1.8,0.0305,10,-0.2,0.0893,-0.1,0.00858,0.873,-4.6,3.3
ENSMUSG00000076430,HUS1B,HUS1 checkpoint homolog b (S. pombe),nucleolus|checkpoint clamp complex|,DNA damage checkpoint|DNA repair|,None,9,-0.6,0.201,9,0,0,-0.1,0.00839,0.873,-4.2,2.4
ENSMUSG00000071573,RNLS,"renalase, FAD-dependent amine oxidase",extracellular space|,response to ischemia|oxidation-reduction process|response to epinephrine|response to salt|,oxidoreductase activity|,10,0.2,0.0537,10,0,0,0.1,0.00835,0.873,-3.2,3.8
ENSMUSG00000016933,PLCG1,"phospholipase C, gamma 1",ruffle|cytoplasm|cytosol|cytosol|plasma membrane|plasma membrane|COP9 signalosome|lamellipodium|cell projection|,activation of MAPKK activity|in utero embryonic development|signal transduction|signal transduction|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|axon guidance|blood coagulation|fibroblast growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of epithelial cell migration|viral process|cell migration|cytokine-mediated signaling pathway|calcium-mediated signaling|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of blood vessel endothelial cell migration|inositol phosphate metabolic process|small molecule metabolic process|innate immune response|positive regulation of angiogenesis|neurotrophin TRK receptor signaling pathway|T cell receptor signaling pathway|leukocyte migration|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|cellular response to epidermal growth factor stimulus|,phosphatidylinositol phospholipase C activity|phosphatidylinositol phospholipase C activity|phospholipase C activity|receptor signaling protein activity|neurotrophin TRKA receptor binding|calcium ion binding|protein binding|protein kinase binding|receptor tyrosine kinase binding|glutamate receptor binding|,9,0,0,9,4.6,0.37,-0.1,0.0082,0.874,-3.7,8.9
ENSMUSG00000033157,ABHD10,abhydrolase domain containing 10,mitochondrion|cytosol|,glucuronoside catabolic process|,"hydrolase activity, hydrolyzing O-glycosyl compounds|",0,0,0,1,0.1,0.00872,0.1,0.00793,0.874,-1.8,2
ENSMUSG00000004032,GSTM5,glutathione S-transferase mu 5,cytosol|,glutathione metabolic process|xenobiotic metabolic process|small molecule metabolic process|glutathione derivative biosynthetic process|,glutathione transferase activity|,10,-0.3,0.115,10,0,0,-0.1,0.00763,0.874,-2.8,2.1
ENSMUSG00000000148,BRAT1,BRCA1-associated ATM activator 1,nucleus|membrane|,response to ionizing radiation|,protein binding|,10,0,0,10,-0.7,0.451,-0.1,0.00756,0.875,-3.7,2.6
ENSMUSG00000019920,LIMS1,LIM and senescent cell antigen-like domains 1,cytosol|plasma membrane|focal adhesion|focal adhesion|perinuclear region of cytoplasm|,"cell aging|cell junction assembly|negative regulation of transcription, DNA-templated|cellular response to transforming growth factor beta stimulus|",protein binding|zinc ion binding|,10,1.2,0.33,10,-0.2,0.0267,-0.1,0.00734,0.875,-3.3,4.7
ENSMUSG00000004651,TYR,tyrosinase,cytoplasm|lysosome|Golgi-associated vesicle|integral component of membrane|melanosome membrane|melanosome|perinuclear region of cytoplasm|,melanin biosynthetic process from tyrosine|eye pigment biosynthetic process|visual perception|cell proliferation|thymus development|oxidation-reduction process|,monophenol monooxygenase activity|copper ion binding|protein binding|protein homodimerization activity|protein heterodimerization activity|,9,0,0,10,0.2,0.0504,0.1,0.00671,0.876,-3.2,3.3
ENSMUSG00000049680,URGCP,upregulator of cell proliferation,nucleus|cytoplasm|,cell cycle|,GTP binding|,1,-0.2,0.00733,0,0,0,-0.2,0.00666,0.876,-2,1.8
ENSMUSG00000007989,FZD3,frizzled class receptor 3,cytoplasm|plasma membrane|plasma membrane|integral component of membrane|apical plasma membrane|lateral plasma membrane|axon|dendrite|neuron projection membrane|neuronal cell body|apical part of cell|presynaptic active zone|,establishment of planar polarity|neuron migration|neural tube closure|hair follicle development|vasculature development|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|gonad development|facial nucleus development|neuron differentiation|cell proliferation in midbrain|post-anal tail morphogenesis|inner ear morphogenesis|canonical Wnt signaling pathway|commissural neuron axon guidance|,G-protein coupled receptor activity|protein binding|Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|Wnt-activated receptor activity|,10,-2,0.559,10,0,0,0.1,0.00663,0.876,-6.9,3.5
ENSMUSG00000039244,E130309D02RIK,RIKEN cDNA E130309D02 gene,cellular_component|,biological_process|,molecular_function|,10,-0.1,0.00701,10,-0.1,0.000226,-0.1,0.00657,0.876,-6.5,2
ENSMUSG00000060275,NRG2,neuregulin 2,extracellular region|plasma membrane|integral component of membrane|,signal transduction|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|embryo development|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|,receptor binding|growth factor activity|,10,-0.5,0.258,10,0,0,-0.1,0.00648,0.876,-4.2,3.7
ENSMUSG00000027832,PTX3,"pentraxin 3, long",extracellular region|extracellular space|,response to yeast|inflammatory response|opsonization|innate immune response|positive regulation of nitric oxide biosynthetic process|negative regulation of viral entry into host cell|positive regulation of phagocytosis|negative regulation of exo-alpha-sialidase activity|negative regulation of glycoprotein metabolic process|,complement component C1q binding|(1->3)-beta-D-glucan binding|virion binding|,10,-0.5,0.0609,10,0,0,-0.3,0.00638,0.876,-4,2.3
ENSMUSG00000055435,MAF,v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog,chromatin|nucleus|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|cytokine production|transcription from RNA polymerase II promoter|regulation of chondrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|cell development|inner ear development|lens fiber cell differentiation|,sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,-0.7,0.373,10,0,0,-0.1,0.00585,0.877,-3,1.8
ENSMUSG00000003948,MMD,monocyte to macrophage differentiation-associated,lysosomal membrane|integral component of plasma membrane|membrane|late endosome membrane|,cytolysis|,receptor activity|,0,0,0,1,-0.2,0.00629,-0.2,0.00572,0.877,-2,1.8
ENSMUSG00000019467,ARHGEF25,Rho guanine nucleotide exchange factor (GEF) 25,cytosol|plasma membrane|myofibril|sarcomere|,positive regulation of Rho GTPase activity|,Rho guanyl-nucleotide exchange factor activity|,9,-0.7,0.358,9,0,0,-0.1,0.00515,0.878,-3.9,3.4
ENSMUSG00000019256,AHR,aryl hydrocarbon receptor,nucleus|transcription factor complex|cytoplasm|cytosolic aryl hydrocarbon receptor complex|,"negative regulation of transcription from RNA polymerase II promoter|blood vessel development|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|xenobiotic metabolic process|apoptotic process|response to stress|cell cycle|response to xenobiotic stimulus|regulation of gene expression|intracellular receptor signaling pathway|prostate gland development|regulation of B cell proliferation|circadian regulation of gene expression|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|",DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|signal transducer activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|transcription factor binding|enhancer binding|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|protein dimerization activity|Hsp90 protein binding|E-box binding|,10,-0.4,0.145,10,0,0,-0.1,0.00463,0.878,-3.5,3.5
ENSMUSG00000006281,TEP1,telomerase-associated protein 1,"chromosome, telomeric region|telomerase holoenzyme complex|cytoplasm|nuclear matrix|ribonucleoprotein complex|",telomere maintenance via recombination|RNA-dependent DNA replication|,telomerase activity|RNA binding|ATP binding|,9,0.4,0.154,9,-0.2,0.0677,-0.1,0.00457,0.878,-3.4,3.1
ENSMUSG00000020865,ABCC3,"ATP-binding cassette, sub-family C (CFTR/MRP), member 3",plasma membrane|integral component of plasma membrane|membrane|,ATP catabolic process|transport|bile acid metabolic process|bile acid and bile salt transport|small molecule metabolic process|transmembrane transport|,"ATP binding|organic anion transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of substances|",10,-0.1,0.0142,10,0,0,-0.1,0.0041,0.879,-3.2,2.4
ENSMUSG00000029455,ALDH2,aldehyde dehydrogenase 2 family (mitochondrial),mitochondrial matrix|extracellular vesicular exosome|,carbohydrate metabolic process|alcohol metabolic process|ethanol catabolic process|ethanol oxidation|xenobiotic metabolic process|synaptic transmission|neurotransmitter biosynthetic process|small molecule metabolic process|,aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|electron carrier activity|,10,-4.2,0.406,10,0,0,-0.1,0.00399,0.879,-8.3,3.7
ENSMUSG00000028560,USP1,ubiquitin specific peptidase 1,nucleus|nucleoplasm|,DNA repair|regulation of DNA repair|ubiquitin-dependent protein catabolic process|response to UV|protein deubiquitination|monoubiquitinated protein deubiquitination|,cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|ubiquitin-specific protease activity|protein binding|,10,0,0,10,-1.1,0.567,-0.1,0.0039,0.88,-6.7,5
ENSMUSG00000050931,SGMS2,sphingomyelin synthase 2,Golgi apparatus|plasma membrane|integral component of plasma membrane|integral component of Golgi membrane|integral component of cell outer membrane|,sphingolipid metabolic process|sphingomyelin biosynthetic process|phosphorylation|sphingolipid biosynthetic process|small molecule metabolic process|,kinase activity|sphingomyelin synthase activity|ceramide cholinephosphotransferase activity|,10,-0.1,0.00319,10,1,0.608,0.2,0.00389,0.88,-3.9,3.9
ENSMUSG00000063252,GM4744,trypsinogen pseudogene,None,None,None,1,-0.1,0.0068,1,0,0,-0.1,0.00369,0.88,-2,1.8
ENSMUSG00000020287,MPG,N-methylpurine-DNA glycosylase,nucleoplasm|mitochondrial nucleoid|,"DNA repair|base-excision repair|base-excision repair|base-excision repair, AP site formation|DNA dealkylation involved in DNA repair|depurination|",damaged DNA binding|alkylbase DNA N-glycosylase activity|protein binding|DNA-3-methyladenine glycosylase activity|DNA-7-methylguanine glycosylase activity|DNA-7-methyladenine glycosylase activity|DNA-3-methylguanine glycosylase activity|,10,-0.2,0.0393,10,0,0,-0.1,0.00363,0.88,-5,2
ENSMUSG00000020891,ALOX8,arachidonate 8-lipoxygenase,intracellular|cytoplasm|cytosol|cytoskeleton|plasma membrane|membrane|extrinsic component of membrane|,lipid metabolic process|negative regulation of cell proliferation|positive regulation of macrophage derived foam cell differentiation|arachidonic acid metabolic process|arachidonic acid metabolic process|lipoxygenase pathway|lipoxygenase pathway|positive regulation of peroxisome proliferator activated receptor signaling pathway|linoleic acid metabolic process|positive regulation of keratinocyte differentiation|negative regulation of cell cycle|negative regulation of growth|hepoxilin biosynthetic process|oxidation-reduction process|positive regulation of chemokine secretion|,"iron ion binding|calcium ion binding|lipid binding|linoleate 13S-lipoxygenase activity|oxidoreductase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|2,3-dihydroxy DDT 1,2-dioxygenase activity|phenanthrene dioxygenase activity|2,2',3-trihydroxybiphenyl dioxygenase activity|1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity|5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity|1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity|protocatechuate 3,4-dioxygenase type II activity|2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity|3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity|2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity|carbazole 1,9a-dioxygenase activity|dihydroxydibenzothiophene dioxygenase activity|1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity|styrene dioxygenase activity|3,4-dihydroxyphenanthrene dioxygenase activity|hydroquinone 1,2-dioxygenase activity|p-cumate 2,3-dioxygenase activity|2,3-dihydroxy-p-cumate dioxygenase activity|3,5-dichlorocatechol 1,2-dioxygenase activity|2-aminophenol 1,6-dioxygenase activity|2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity|chlorocatechol 1,2-dioxygenase activity|catechol dioxygenase activity|dihydroxyfluorene dioxygenase activity|5-aminosalicylate dioxygenase activity|3-hydroxy-2-naphthoate 2,3-dioxygenase activity|benzo(a)pyrene 11,12-dioxygenase activity|benzo(a)pyrene 4,5-dioxygenase activity|4,5-dihydroxybenzo(a)pyrene dioxygenase activity|benzo(a)pyrene 9,10-dioxygenase activity|9,10-dihydroxybenzo(a)pyrene dioxygenase activity|benzo(a)pyrene 7,8-dioxygenase activity|7,8-dihydroxy benzo(a)pyrene dioxygenase activity|1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity|2-mercaptobenzothiazole dioxygenase activity|pyridine-3,4-diol dioxygenase activity|pyrene dioxygenase activity|4,5-dihydroxypyrene dioxygenase activity|phenanthrene-4-carboxylate dioxygenase activity|tetrachlorobenzene dioxygenase activity|4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity|2,3-dihydroxydiphenyl ether dioxygenase activity|diphenyl ether 1,2-dioxygenase activity|arachidonate 8(S)-lipoxygenase activity|metal ion binding|4-hydroxycatechol 1,2-dioxygenase activity|arachidonate 8(R)-lipoxygenase activity|arachidonate 15-lipoxygenase activity|dioxygenase activity|",10,-2.2,1.27,10,0,0,-0.1,0.00362,0.88,-6.9,1.8
ENSMUSG00000029999,TGFA,"transforming growth factor, alpha",extracellular space|nucleus|plasma membrane|cell surface|integral component of membrane|basolateral plasma membrane|cytoplasmic vesicle|perinuclear region of cytoplasm|,MAPK cascade|activation of MAPK activity|angiogenesis|epidermal growth factor receptor signaling pathway|cell proliferation|wound healing|response to drug|negative regulation of apoptotic process|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitosis|positive regulation of epithelial cell proliferation|positive regulation of cell division|mammary gland alveolus development|,glycoprotein binding|MAP kinase kinase activity|epidermal growth factor receptor binding|protein binding|growth factor activity|,10,0,0,10,-0.3,0.183,-0.1,0.00358,0.88,-7.5,2.6
ENSMUSG00000044177,WFIKKN2,"WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2",extracellular region|,transforming growth factor beta receptor signaling pathway|negative regulation of endopeptidase activity|,serine-type endopeptidase inhibitor activity|metalloendopeptidase inhibitor activity|,0,0,0,1,-0.1,0.00391,-0.1,0.00356,0.88,-2,1.8
ENSMUSG00000033111,3830406C13RIK,RIKEN cDNA 3830406C13 gene,cellular_component|,biological_process|,molecular_function|,10,0,0,10,-0.3,0.0179,-0.1,0.00348,0.88,-5.2,2
ENSMUSG00000039653,BAAT,bile acid CoA:amino acid N-acyltransferase,peroxisome|peroxisomal matrix|cytosol|cytosol|,liver development|bile acid conjugation|glycine metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|bile acid biosynthetic process|bile acid biosynthetic process|bile acid metabolic process|bile acid and bile salt transport|taurine metabolic process|organ regeneration|small molecule metabolic process|,receptor binding|palmitoyl-CoA hydrolase activity|N-acyltransferase activity|glycine N-choloyltransferase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|very long chain acyl-CoA hydrolase activity|,10,0,0,10,0.7,0.312,0.1,0.0033,0.88,-8.4,5.8
ENSMUSG00000035342,LZTS2,"leucine zipper, putative tumor suppressor 2",cytoplasm|centrosome|microtubule|midbody|,cytokinesis|mitotic nuclear division|Wnt signaling pathway|negative regulation of Wnt signaling pathway|microtubule severing|nuclear export|spindle midzone assembly|,protein binding|,10,0,0,10,0.5,0.214,0.2,0.00328,0.88,-2.5,3.1
ENSMUSG00000037446,TULP1,tubby like protein 1,photoreceptor outer segment|photoreceptor inner segment|extracellular region|cytoplasm|plasma membrane|cell junction|cell projection|synapse|,retina homeostasis|phagocytosis|visual perception|phototransduction|dendrite development|eye photoreceptor cell development|photoreceptor cell maintenance|positive regulation of phagocytosis|detection of light stimulus involved in visual perception|retina development in camera-type eye|,"protein binding|phosphatidylinositol-4,5-bisphosphate binding|G-protein coupled photoreceptor activity|actin filament binding|",10,0.3,0.0258,10,-0.1,0.0165,-0.1,0.00327,0.88,-6.5,4.4
ENSMUSG00000066441,RDH11,retinol dehydrogenase 11 (all-trans/9-cis/11-cis),photoreceptor inner segment|intracellular|endoplasmic reticulum membrane|integral component of membrane|,"retinoid metabolic process|phototransduction, visible light|adaptation of rhodopsin mediated signaling|retinol metabolic process|retinal metabolic process|oxidation-reduction process|",retinol dehydrogenase activity|NADP-retinol dehydrogenase activity|,10,0.2,0.0441,10,0,0,0.1,0.00321,0.88,-2.3,2.6
ENSMUSG00000036770,4933433C11RIK,RIKEN cDNA 4933433C11 gene,cellular_component|,biological_process|,molecular_function|,1,0,0,1,-0.3,0.0286,-0.1,0.00304,0.881,-2,1.8
ENSMUSG00000032350,GCLC,"glutamate-cysteine ligase, catalytic subunit",cytoplasm|cytosol|glutamate-cysteine ligase complex|,"sulfur amino acid metabolic process|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|glutathione biosynthetic process|glutathione biosynthetic process|glutathione biosynthetic process|xenobiotic metabolic process|response to oxidative stress|apoptotic mitochondrial changes|response to heat|response to hormone|L-ascorbic acid metabolic process|negative regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular nitrogen compound metabolic process|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|small molecule metabolic process|cell redox homeostasis|negative regulation of transcription, DNA-templated|response to arsenic-containing substance|regulation of blood vessel size|response to nitrosative stress|regulation of mitochondrial depolarization|glutathione derivative biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway|",magnesium ion binding|glutamate-cysteine ligase activity|glutamate-cysteine ligase activity|ATP binding|glutamate binding|ADP binding|protein heterodimerization activity|coenzyme binding|,10,-0.3,0.0802,10,0.7,0.269,-0.1,0.00298,0.881,-5,3.6
ENSMUSG00000023830,IGF2R,insulin-like growth factor 2 receptor,extracellular space|nuclear envelope lumen|lysosomal membrane|endosome|late endosome|integral component of plasma membrane|cell surface|membrane|clathrin coat|endocytic vesicle|trans-Golgi network transport vesicle|perinuclear region of cytoplasm|extracellular vesicular exosome|,liver development|receptor-mediated endocytosis|signal transduction|G-protein coupled receptor signaling pathway|spermatogenesis|post-embryonic development|organ regeneration|response to retinoic acid|positive regulation of apoptotic process|insulin-like growth factor receptor signaling pathway|,glycoprotein binding|G-protein alpha-subunit binding|retinoic acid binding|receptor activity|G-protein coupled receptor activity|insulin-like growth factor-activated receptor activity|transporter activity|protein binding|mannose binding|enzyme binding|insulin-like growth factor II binding|identical protein binding|phosphoprotein binding|,10,-1.2,0.825,10,0.1,0.00566,-0.1,0.00291,0.881,-4.6,3.1
ENSMUSG00000036199,NDUFA13,"NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13",nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial respiratory chain complex I|integral component of membrane|mitochondrial membrane|extracellular vesicular exosome|,"respiratory electron transport chain|negative regulation of cell growth|negative regulation of cell growth|cellular metabolic process|small molecule metabolic process|protein import into mitochondrial inner membrane|negative regulation of transcription, DNA-templated|reactive oxygen species metabolic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway|",NADH dehydrogenase activity|protein binding|ATP binding|NADH dehydrogenase (ubiquinone) activity|,9,-0.8,0.503,9,0.4,0.149,0.1,0.00285,0.881,-2.7,2.3
ENSMUSG00000081683,FZD10,frizzled class receptor 10,cytoplasm|plasma membrane|integral component of plasma membrane|cell surface|cell projection|,vasculature development|G-protein coupled receptor signaling pathway|brain development|gonad development|neuron differentiation|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|negative regulation of Rho GTPase activity|non-canonical Wnt signaling pathway via JNK cascade|positive regulation of JUN kinase activity|canonical Wnt signaling pathway|cellular response to retinoic acid|,G-protein coupled receptor activity|protein binding|Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|,10,0,0,10,-0.1,0.00416,-0.1,0.00278,0.881,-3.5,2.8
ENSMUSG00000031530,DUSP4,dual specificity phosphatase 4,nucleus|nucleoplasm|,MAPK cascade|inactivation of MAPK activity|endoderm formation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein dephosphorylation|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|peptidyl-tyrosine dephosphorylation|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|stress-activated MAPK cascade|,protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|,10,0.2,0.0568,10,0,0,0.1,0.00226,0.882,-4.5,4.9
ENSMUSG00000029482,AACS,acetoacetyl-CoA synthetase,cytosol|,liver development|fatty acid metabolic process|response to nutrient|response to purine-containing compound|positive regulation of insulin secretion|response to oleic acid|response to drug|response to starvation|response to ethanol|white fat cell differentiation|adipose tissue development|cellular response to glucose stimulus|cellular response to testosterone stimulus|cellular response to cholesterol|,ATP binding|acetoacetate-CoA ligase activity|butyrate-CoA ligase activity|,10,-0.1,0.0103,10,0,0,-0.1,0.00212,0.882,-6.4,2
ENSMUSG00000005103,WDR1,WD repeat domain 1,podosome|extracellular region|cytoplasm|cytosol|cell junction|cell projection|extracellular vesicular exosome|,platelet degranulation|blood coagulation|sensory perception of sound|platelet activation|,actin binding|,10,0,0,10,-0.6,0.183,-0.1,0.00205,0.882,-8.6,4
ENSMUSG00000045064,ZC2HC1C,"zinc finger, C2HC-type containing 1C",None,None,metal ion binding|,10,-2.6,0.207,10,0,0,-0.1,0.00199,0.882,-9.5,2.2
ENSMUSG00000092305,PRPS1L1,phosphoribosyl pyrophosphate synthetase 1-like 1,cellular_component|,5-phosphoribose 1-diphosphate biosynthetic process|ribonucleoside monophosphate biosynthetic process|nucleotide biosynthetic process|phosphorylation|,magnesium ion binding|ribose phosphate diphosphokinase activity|ribose phosphate diphosphokinase activity|ATP binding|kinase activity|protein homodimerization activity|,1,0.1,0.00789,1,0,0,0.1,0.00122,0.883,-1.8,2
ENSMUSG00000000134,TFE3,transcription factor binding to IGHM enhancer 3,nucleus|nucleus|cytoplasm|,"transcription, DNA-templated|humoral immune response|regulation of osteoclast differentiation|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|",sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|protein dimerization activity|,9,-0.9,0.527,9,0,0,-0.1,0.0011,0.883,-5.4,2.7
ENSMUSG00000054823,WHSC1L1,Wolf-Hirschhorn syndrome candidate 1-like 1,nucleus|chromosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|histone methylation|histone lysine methylation|histone lysine methylation|",protein binding|zinc ion binding|histone-lysine N-methyltransferase activity|,10,-0.5,0.198,10,0,0,-0.1,0.00105,0.883,-3.6,2
ENSMUSG00000017652,CD40,"CD40 molecule, TNF receptor superfamily member 5",extracellular space|cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|CD40 receptor complex|intracellular membrane-bounded organelle|extracellular vesicular exosome|,positive regulation of protein phosphorylation|immune response-regulating cell surface receptor signaling pathway|protein complex assembly|cellular calcium ion homeostasis|inflammatory response|platelet activation|positive regulation of B cell proliferation|positive regulation of interleukin-12 production|positive regulation of Rac GTPase activity|B cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of Cdc42 GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of isotype switching to IgG isotypes|regulation of immune response|regulation of immunoglobulin secretion|positive regulation of NF-kappaB transcription factor activity|defense response to virus|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|positive regulation of protein kinase C signaling|positive regulation of endothelial cell apoptotic process|,antigen binding|signal transducer activity|receptor activity|protein binding|enzyme binding|ubiquitin protein ligase binding|,10,0,0,10,-0.3,0.0903,-0.1,0.00104,0.883,-9.7,3
ENSMUSG00000032812,ARAP1,"ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1",Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|cytoplasmic vesicle|Golgi cisterna membrane|,positive regulation of receptor recycling|small GTPase mediated signal transduction|regulation of cell shape|actin filament reorganization involved in cell cycle|regulation of ARF GTPase activity|positive regulation of Cdc42 GTPase activity|regulation of small GTPase mediated signal transduction|regulation of cellular component movement|positive regulation of filopodium assembly|negative regulation of stress fiber assembly|,"Rho GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|ARF GTPase activator activity|zinc ion binding|type 1 angiotensin receptor binding|",10,-0.7,0.189,10,0.2,0.0293,0.1,0.000979,0.883,-2.5,2.4
ENSMUSG00000026942,TRAF2,TNF receptor-associated factor 2,cytoplasm|cytosol|cell cortex|cytoplasmic side of plasma membrane|CD40 receptor complex|membrane raft|,positive regulation of T cell cytokine production|protein complex assembly|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|activation of NF-kappaB-inducing kinase activity|protein catabolic process|positive regulation of interleukin-2 production|tumor necrosis factor-mediated signaling pathway|negative regulation of glial cell apoptotic process|regulation of apoptotic process|positive regulation of JUN kinase activity|cellular protein complex assembly|innate immune response|positive regulation of T cell activation|regulation of immunoglobulin secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein heterooligomerization|protein autoubiquitination|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|positive regulation of protein homodimerization activity|apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|,ubiquitin-protein transferase activity|signal transducer activity|tumor necrosis factor receptor binding|CD40 receptor binding|protein binding|zinc ion binding|ligase activity|enzyme binding|protein phosphatase binding|mitogen-activated protein kinase kinase kinase binding|ubiquitin protein ligase binding|thioesterase binding|protein complex binding|identical protein binding|sphingolipid binding|,9,0,0,9,-0.1,0.00792,-0.1,0.00073,0.884,-2.5,1.7
ENSMUSG00000024069,SLC30A6,"solute carrier family 30 (zinc transporter), member 6",Golgi membrane|mitochondrion|Golgi apparatus|integral component of membrane|,Golgi to endosome transport|cellular protein metabolic process|transmembrane transport|zinc ion transmembrane transport|,zinc ion transmembrane transporter activity|,1,-0.1,0.000747,0,0,0,-0.1,0.000679,0.884,-2,1.8
ENSMUSG00000028636,PPCS,phosphopantothenoylcysteine synthetase,cytosol|extracellular vesicular exosome|,vitamin metabolic process|water-soluble vitamin metabolic process|coenzyme biosynthetic process|coenzyme A biosynthetic process|coenzyme A biosynthetic process|pantothenate metabolic process|small molecule metabolic process|,phosphopantothenate--cysteine ligase activity|phosphopantothenate--cysteine ligase activity|,10,0,0,10,-0.5,0.217,-0.1,0.00037,0.884,-2.9,2
ENSMUSG00000024224,CLPSL2,colipase-like 2,extracellular region|,digestion|lipid catabolic process|positive regulation of catalytic activity|,enzyme activator activity|,1,0.1,0.00029,0,0,0,0.1,0.000264,0.884,-1.8,2
ENSMUSG00000028039,EFNA3,ephrin-A3,plasma membrane|integral component of plasma membrane|anchored component of membrane|,cell-cell signaling|axon guidance|ephrin receptor signaling pathway|ephrin receptor signaling pathway|,transmembrane-ephrin receptor activity|ephrin receptor binding|,1,-0.1,0.000248,0,0,0,-0.1,0.000226,0.884,-2,1.8
ENSMUSG00000024301,KIFC5B,kinesin family member C5B,membrane|,biological_process|,molecular_function|,10,-1.2,0.591,10,0.3,0.226,0,0,0.885,-3.4,2.3
ENSMUSG00000023800,TIAM2,T-cell lymphoma invasion and metastasis 2,cytosol|membrane|lamellipodium|filopodium|growth cone|extracellular vesicular exosome|,small GTPase mediated signal transduction|positive regulation of Rho GTPase activity|positive regulation of apoptotic process|cellular lipid metabolic process|small molecule metabolic process|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,receptor signaling protein activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|,10,-5.4,0.328,10,0,0,0,0,0.885,-9.8,3.2
ENSMUSG00000022772,SENP5,SUMO1/sentrin specific peptidase 5,nucleus|nucleoplasm|nucleolus|intracellular membrane-bounded organelle|,proteolysis|cell cycle|protein sumoylation|post-translational protein modification|cellular protein metabolic process|cell division|,protein binding|cysteine-type peptidase activity|,10,0,0,10,0,0,0,0,0.885,-5.9,5.1
ENSMUSG00000026586,PRRX1,paired related homeobox 1,nucleus|nucleolus|,negative regulation of transcription from RNA polymerase II promoter|positive regulation of mesenchymal cell proliferation|embryonic limb morphogenesis|inner ear morphogenesis|middle ear morphogenesis|positive regulation of smoothened signaling pathway|embryonic cranial skeleton morphogenesis|artery morphogenesis|cartilage development|palate development|,sequence-specific DNA binding transcription factor activity|transcription coactivator activity|sequence-specific DNA binding|HMG box domain binding|,10,0,0,10,-0.2,0.0288,0,0,0.885,-3.7,3.4
ENSMUSG00000002058,UNC119,unc-119 homolog (C. elegans),spindle pole|centrosome|cytosol|intercellular bridge|spindle midzone|,"cytokinesis, completion of separation|synaptic transmission|visual perception|phototransduction|lipoprotein transport|positive regulation of protein tyrosine kinase activity|negative regulation of clathrin-mediated endocytosis|negative regulation of caveolin-mediated endocytosis|",protein binding|lipid binding|,10,-0.3,0.0636,10,0,0,0,0,0.885,-7.2,3.3
ENSMUSG00000039410,PRDM16,PR domain containing 16,nucleus|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|neurogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of granulocyte differentiation|somatic stem cell maintenance|regulation of cellular respiration|tongue development|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|white fat cell differentiation|brown fat cell differentiation|palate development|",transcription coactivator activity|protein binding|sequence-specific DNA binding|SMAD binding|metal ion binding|,10,5.5,1.56,10,-0.2,0.0223,0,0,0.885,-2.7,11.3
ENSMUSG00000023990,TFEB,transcription factor EB,nucleus|nucleus|transcription factor complex|cytoplasm|,"embryonic placenta development|transcription, DNA-templated|regulation of transcription, DNA-templated|autophagy|humoral immune response|lysosome organization|positive regulation of autophagy|positive regulation of transcription from RNA polymerase II promoter|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|protein heterodimerization activity|,10,0,0,10,0,0,0,0,0.885,-2.6,3.1
ENSMUSG00000022892,APP,amyloid beta (A4) precursor protein,extracellular region|extracellular space|nuclear envelope lumen|cytoplasm|cytoplasm|Golgi apparatus|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|coated pit|cell surface|integral component of membrane|axon|platelet alpha granule lumen|neuromuscular junction|ciliary rootlet|dendritic spine|dendritic shaft|intracellular membrane-bounded organelle|receptor complex|membrane raft|apical part of cell|synapse|perinuclear region of cytoplasm|spindle midzone|extracellular vesicular exosome|,"mitotic G2 phase|suckling behavior|platelet degranulation|mRNA polyadenylation|regulation of translation|protein phosphorylation|cellular copper ion homeostasis|endocytosis|response to oxidative stress|cell adhesion|regulation of epidermal growth factor-activated receptor activity|Notch signaling pathway|axonogenesis|blood coagulation|mating behavior|locomotory behavior|axon cargo transport|cholesterol metabolic process|adult locomotory behavior|visual learning|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|positive regulation of peptidase activity|positive regulation of G2/M transition of mitotic cell cycle|axon midline choice point recognition|neuron remodeling|dendrite development|platelet activation|extracellular matrix organization|extracellular matrix organization|forebrain development|neuron projection development|ionotropic glutamate receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|regulation of multicellular organism growth|regulation of protein binding|innate immune response|negative regulation of neuron differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|collateral sprouting in absence of injury|regulation of synapse structure and activity|neuromuscular process controlling balance|synaptic growth at neuromuscular junction|neuron apoptotic process|smooth endoplasmic reticulum calcium ion homeostasis|",DNA binding|serine-type endopeptidase inhibitor activity|receptor binding|protein binding|heparin binding|peptidase activator activity|enzyme binding|acetylcholine receptor binding|identical protein binding|transition metal ion binding|PTB domain binding|growth factor receptor binding|,10,0,0,10,0.8,0.505,0,0,0.885,-3.3,3.7
ENSMUSG00000034041,LYL1,lymphoblastic leukemia associated hematopoiesis regulator 1,nucleus|,"blood vessel maturation|transcription, DNA-templated|regulation of transcription, DNA-templated|B cell differentiation|positive regulation of transcription, DNA-templated|definitive hemopoiesis|",DNA binding|protein binding|protein dimerization activity|,10,0,0,10,0.7,0.00707,0,0,0.885,-2.8,3.7
ENSMUSG00000026083,EIF5B,eukaryotic translation initiation factor 5B,cytosol|,GTP catabolic process|translation|translational initiation|regulation of translational initiation|regulation of translational initiation|gene expression|cellular protein metabolic process|,translation initiation factor activity|translation initiation factor activity|GTPase activity|protein binding|GTP binding|poly(A) RNA binding|,9,-5.7,0.473,9,1,0.476,0,0,0.885,-10.2,4.4
ENSMUSG00000056643,CHST13,carbohydrate (chondroitin 4) sulfotransferase 13,Golgi membrane|integral component of membrane|,carbohydrate metabolic process|carbohydrate biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate biosynthetic process|small molecule metabolic process|,N-acetylgalactosamine 4-O-sulfotransferase activity|chondroitin 4-sulfotransferase activity|,10,0,0,10,0,0,0,0,0.885,-2.7,2.9
ENSMUSG00000021611,TERT,telomerase reverse transcriptase,"chromosome, telomeric region|nuclear telomere cap complex|nucleoplasm|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytoplasm|PML body|",telomere maintenance|telomere maintenance via telomerase|telomere maintenance via telomerase|DNA strand elongation|telomere formation via telomerase|replicative senescence|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|,telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric template RNA reverse transcriptase activity|protein binding|telomeric DNA binding|protein homodimerization activity|metal ion binding|telomeric RNA binding|,10,0,0,10,0.4,0.107,0,0,0.885,-2.5,1.7
ENSMUSG00000021198,UNC79,unc-79 homolog (C. elegans),plasma membrane|integral component of membrane|,ion transmembrane transport|multicellular organism growth|behavioral response to ethanol|transmembrane transport|,None,10,0,0,10,1.1,0.668,0,0,0.885,-7.8,5
ENSMUSG00000030878,CDR2,"cerebellar degeneration-related protein 2, 62kDa",cytoplasm|,None,molecular_function|protein binding|,10,0,0,10,0,0,0,0,0.885,-3.5,3
ENSMUSG00000037111,SETD7,SET domain containing (lysine methyltransferase) 7,nucleus|chromosome|,"transcription, DNA-templated|regulation of transcription, DNA-templated|chromatin modification|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone lysine methylation|",p53 binding|protein binding|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|,10,-0.3,0.109,10,0,0,0,0,0.885,-3.6,2.8
ENSMUSG00000026879,GSN,gelsolin,ruffle|extracellular region|extracellular region|extracellular region|extracellular region|cytosol|cytosol|cytosol|actin cytoskeleton|lamellipodium|protein complex|perinuclear region of cytoplasm|extracellular vesicular exosome|blood microparticle|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|aging|oligodendrocyte development|vesicle-mediated transport|actin filament polymerization|actin filament polymerization|regulation of cell adhesion|tissue regeneration|response to ethanol|phosphatidylinositol-mediated signaling|actin filament severing|actin filament severing|barbed-end actin filament capping|response to folic acid|cilium morphogenesis|cellular response to cadmium ion|,actin binding|calcium ion binding|protein binding|,10,0,0,10,-1.2,0.544,0,0,0.885,-4.6,1.9
ENSMUSG00000036046,5031439G07RIK,RIKEN cDNA 5031439G07 gene,cellular_component|,biological_process|,molecular_function|,10,-1.1,0.465,10,0,0,0,0,0.885,-7.9,3
ENSMUSG00000044407,QK,quaking,nucleus|cytoplasm|,vasculogenesis|mRNA processing|regulation of translation|transport|multicellular organismal development|spermatid development|axon ensheathment|RNA splicing|positive regulation of gene expression|cell differentiation|myelination|muscle cell differentiation|long-chain fatty acid biosynthetic process|mRNA transport|3'-UTR-mediated mRNA destabilization|,RNA binding|mRNA binding|SH3 domain binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-2,2.2
ENSMUSG00000031171,FTSJ1,FtsJ RNA methyltransferase homolog 1 (E. coli),cytoplasm|,tRNA nucleoside ribose methylation|cytoplasmic translation|,tRNA methyltransferase activity|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000047514,TSPYL1,TSPY-like 1,nucleolus|,nucleosome assembly|biological_process|,enzyme binding|,10,0,0,10,0.9,0.297,0,0,0.885,-5,4
ENSMUSG00000094881,GM6026,predicted gene 6026,cellular_component|,biological_process|,molecular_function|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000033427,UPB1,"ureidopropionase, beta",cytosol|extracellular vesicular exosome|,pyrimidine nucleobase metabolic process|beta-alanine biosynthetic process|small molecule metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|,beta-ureidopropionase activity|metal ion binding|,10,0,0,10,0.8,0.3,0,0,0.885,-3.5,5.6
ENSMUSG00000021938,PSPC1,paraspeckle component 1,nucleus|nucleolus|cytoplasm|nuclear matrix|nuclear speck|paraspeckles|,"transcription, DNA-templated|regulation of circadian rhythm|negative regulation of transcription, DNA-templated|",nucleotide binding|core promoter binding|protein binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-6.1,1.9
ENSMUSG00000047878,A4GALT,"alpha 1,4-galactosyltransferase",Golgi stack|membrane|integral component of Golgi membrane|extracellular vesicular exosome|,protein glycosylation|glycosphingolipid biosynthetic process|plasma membrane organization|,galactosyltransferase activity|lactosylceramide 4-alpha-galactosyltransferase activity|,10,0,0,10,0,0,0,0,0.885,-3.2,2.5
ENSMUSG00000018476,KDM6B,lysine (K)-specific demethylase 6B,nucleus|nucleoplasm|,inflammatory response|endothelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|mesodermal cell differentiation|cardiac muscle cell differentiation|oxidation-reduction process|histone H3-K27 demethylation|,protein binding|sequence-specific DNA binding|metal ion binding|dioxygenase activity|histone demethylase activity (H3-K27 specific)|,10,-4,2.85,9,0.3,0.112,0,0,0.885,-8.3,2.2
ENSMUSG00000030979,UROS,uroporphyrinogen III synthase,mitochondrion|cytosol|cytosol|,porphyrin-containing compound metabolic process|uroporphyrinogen III biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|heme biosynthetic process|heme biosynthetic process|small molecule metabolic process|response to antibiotic|cellular response to arsenic-containing substance|cellular response to amine stimulus|,uroporphyrinogen-III synthase activity|cofactor binding|,10,0.2,0.0228,10,0,0,0,0,0.885,-6.8,3
ENSMUSG00000025812,PARD3,par-3 family cell polarity regulator,spindle|cytosol|plasma membrane|cell-cell junction|cell-cell junction|cell-cell adherens junction|tight junction|tight junction|cell cortex|endomembrane system|cell junction|cell junction|internode region of axon|neuronal cell body|protein complex|axonal growth cone|apical part of cell|,"microtubule cytoskeleton organization|apical constriction|protein complex assembly|protein targeting to membrane|cell cycle|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|axonogenesis|asymmetric cell division|negative regulation of peptidyl-threonine phosphorylation|myelination in peripheral nervous system|positive regulation of myelination|regulation of actin filament-based process|cell junction assembly|wound healing, spreading of cells|cell-cell junction organization|centrosome localization|regulation of cellular localization|tight junction assembly|tight junction assembly|establishment of epithelial cell polarity|","protein kinase C binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein phosphatase binding|phosphatidylinositol-3-phosphate binding|",10,0,0,10,0,0,0,0,0.885,-7.4,3
ENSMUSG00000025014,DNTT,DNA nucleotidylexotransferase,nucleus|cytoplasm|,DNA-dependent DNA replication|DNA modification|,DNA binding|DNA-directed DNA polymerase activity|DNA nucleotidylexotransferase activity|metal ion binding|,9,0,0,10,0,0,0,0,0.885,-3.7,2.8
ENSMUSG00000029528,PXN,paxillin,nucleus|cytoplasm|microtubule associated complex|plasma membrane|plasma membrane|focal adhesion|cell cortex|lamellipodium|,activation of MAPK activity|cellular component movement|muscle contraction|cytoskeleton organization|cell adhesion|signal transduction|signal complex assembly|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|lamellipodium assembly|cell junction assembly|cellular response to reactive oxygen species|focal adhesion assembly|branching morphogenesis of an epithelial tube|growth hormone receptor signaling pathway|,integrin binding|protein binding|beta-catenin binding|zinc ion binding|vinculin binding|protein kinase binding|BH4 domain binding|,10,0.4,0.223,10,-0.3,0.0602,0,0,0.885,-3,3.3
ENSMUSG00000052469,TCP10C,t-complex protein 10c,cellular_component|,biological_process|,molecular_function|,1,0,0,1,-0.2,0.017,0,0,0.885,-2,1.8
ENSMUSG00000046755,KIF2B,kinesin family member 2B,condensed chromosome kinetochore|nucleus|nucleolus|microtubule organizing center|spindle|cytosol|kinesin complex|microtubule|microtubule cytoskeleton|,mitotic cell cycle|microtubule-based movement|microtubule depolymerization|mitotic nuclear division|blood coagulation|metabolic process|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of chromosome segregation|,microtubule motor activity|ATP binding|microtubule binding|,10,-1.2,0.166,10,0,0,0,0,0.885,-7.1,4.2
ENSMUSG00000041193,PLA2G5,"phospholipase A2, group V",extracellular region|Golgi apparatus|plasma membrane|cell surface|perinuclear region of cytoplasm|,phospholipid metabolic process|phosphatidic acid biosynthetic process|platelet activating factor biosynthetic process|lipid catabolic process|leukotriene biosynthetic process|response to cytokine|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|small molecule metabolic process|glycerophospholipid biosynthetic process|arachidonic acid secretion|response to cAMP|,calcium ion binding|heparin binding|calcium-dependent phospholipase A2 activity|,10,-1,0.572,10,0.3,0.0683,0,0,0.885,-2.9,1.9
ENSMUSG00000022456,3-Sep,septin 3,cell junction|septin complex|synapse|,cell cycle|cell division|,molecular_function|GTP binding|,10,0,0,10,-0.1,0.0304,0,0,0.885,-7.5,1.8
ENSMUSG00000032274,CYP19A1,"cytochrome P450, family 19, subfamily A, polypeptide 1",endoplasmic reticulum|endoplasmic reticulum membrane|membrane|,steroid biosynthetic process|estrogen biosynthetic process|xenobiotic metabolic process|steroid metabolic process|androgen metabolic process|sterol metabolic process|small molecule metabolic process|oxidation-reduction process|prostate gland growth|,"iron ion binding|electron carrier activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|heme binding|aromatase activity|",10,0,0,10,0,0,0,0,0.885,-3.9,4
ENSMUSG00000064284,CDPF1,"cysteine-rich, DPF motif domain containing 1",None,None,None,10,3.7,0.807,10,0,0,0,0,0.885,-3,7.7
ENSMUSG00000031450,GRK1,G protein-coupled receptor kinase 1,photoreceptor disc membrane|,"visual perception|phototransduction, visible light|regulation of G-protein coupled receptor protein signaling pathway|photoreceptor cell morphogenesis|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|termination of G-protein coupled receptor signaling pathway|positive regulation of phosphorylation|negative regulation of apoptotic process|protein autophosphorylation|post-embryonic retina morphogenesis in camera-type eye|",protein kinase activity|G-protein coupled receptor kinase activity|ATP binding|rhodopsin kinase activity|,10,-0.8,0.58,10,0,0,0,0,0.885,-8,2
ENSMUSG00000048240,GNG7,"guanine nucleotide binding protein (G protein), gamma 7",heterotrimeric G-protein complex|plasma membrane|extracellular vesicular exosome|,behavioral fear response|energy reserve metabolic process|receptor guanylyl cyclase signaling pathway|G-protein coupled receptor signaling pathway|synaptic transmission|locomotory behavior|regulation of G-protein coupled receptor protein signaling pathway|small molecule metabolic process|regulation of adenylate cyclase activity|cellular response to glucagon stimulus|,signal transducer activity|,10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000066861,OAS1G,2'-5' oligoadenylate synthetase 1G,nucleus|cytoplasm|,None,2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|zinc ion binding|,9,0,0,10,-0.8,0.45,0,0,0.885,-3,5.9
ENSMUSG00000030339,LTBR,"lymphotoxin beta receptor (TNFR superfamily, member 3)",integral component of membrane|,apoptotic process|signal transduction|viral process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway|,protein binding|ubiquitin protein ligase binding|identical protein binding|,10,0,0,10,0.1,0.00413,0,0,0.885,-6.5,3
ENSMUSG00000045083,LINGO2,leucine rich repeat and Ig domain containing 2,integral component of membrane|,None,None,10,0.2,0.0524,10,0,0,0,0,0.885,-3.7,2.6
ENSMUSG00000073982,RHOG,ras homolog family member G,cytosol|plasma membrane|extracellular vesicular exosome|,"GTP catabolic process|GTP catabolic process|small GTPase mediated signal transduction|Rho protein signal transduction|axon guidance|blood coagulation|positive regulation of cell proliferation|Rac protein signal transduction|actin cytoskeleton organization|platelet activation|activation of Rac GTPase activity|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction|cell chemotaxis|positive regulation of establishment of protein localization to plasma membrane|",GTPase activity|protein binding|GTP binding|,10,0,0,10,0.1,0.00079,0,0,0.885,-9.1,2
ENSMUSG00000038332,SESN1,sestrin 1,nucleus|,cellular response to DNA damage stimulus|cell cycle arrest|negative regulation of cell proliferation|regulation of response to reactive oxygen species|,None,10,-1.6,0.628,10,0,0,0,0,0.885,-8.3,2
ENSMUSG00000050213,SNIP1,Smad nuclear interacting protein 1,nucleus|,"regulation of transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|production of miRNAs involved in gene silencing by miRNA|",protein binding|poly(A) RNA binding|,1,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000026587,ASTN1,astrotactin 1,cellular_component|endosome|external side of plasma membrane|integral component of membrane|,neuron migration|neuron cell-cell adhesion|locomotory behavior|,None,10,0,0,10,0,0,0,0,0.885,-2,2.9
ENSMUSG00000042750,BEX2,brain expressed X-linked 2,nucleus|cytoplasm|,apoptotic process|cell cycle|regulation of apoptotic process|regulation of cell cycle|,None,10,0,0,10,0.2,0.0816,0,0,0.885,-2.7,2
ENSMUSG00000095573,GM16501,predicted gene 16501,cellular_component|,biological_process|,molecular_function|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000017897,EYA2,EYA transcriptional coactivator and phosphatase 2,nucleus|cytoplasm|mitochondrion|centrosome|,"DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|mesodermal cell fate specification|striated muscle tissue development|histone dephosphorylation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|extrinsic apoptotic signaling pathway in absence of ligand|mitochondrial outer membrane permeabilization|",magnesium ion binding|protein tyrosine phosphatase activity|protein binding|,10,0,0,10,0,0,0,0,0.885,-3.2,2.4
ENSMUSG00000031952,CHST5,carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5,Golgi membrane|Golgi apparatus|integral component of membrane|intrinsic component of Golgi membrane|,carbohydrate metabolic process|N-acetylglucosamine metabolic process|protein sulfation|sulfur compound metabolic process|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|small molecule metabolic process|,N-acetylglucosamine 6-O-sulfotransferase activity|sulfotransferase activity|,10,0.1,0.0149,10,0,0,0,0,0.885,-6.2,3.5
ENSMUSG00000049739,ZFP646,zinc finger protein 646,cellular_component|,biological_process|,molecular_function|,10,6.2,3.11,10,-0.1,0.0167,0,0,0.885,-3.3,13
ENSMUSG00000029552,TES,testis derived transcript (3 LIM domains),nucleus|cytoplasm|focal adhesion|protein complex|,negative regulation of cell proliferation|,zinc ion binding|poly(A) RNA binding|,10,-0.1,0.000688,10,0,0,0,0,0.885,-6.4,3
ENSMUSG00000066512,KLK1B5,kallikrein 1-related peptidase b5,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,0,0,10,0,0,0,0,0.885,-6.8,2.1
ENSMUSG00000063428,DDO,D-aspartate oxidase,peroxisome|,aspartate metabolic process|aspartate catabolic process|insemination|grooming behavior|D-amino acid catabolic process|hormone metabolic process|oxidation-reduction process|oxidation-reduction process|,receptor binding|protein binding|D-aspartate oxidase activity|cofactor binding|,10,-5.4,2.28,10,0.5,0.222,0,0,0.885,-9.9,2.5
ENSMUSG00000017929,B4GALT5,"UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5",Golgi membrane|integral component of membrane|Golgi cisterna membrane|extracellular vesicular exosome|,carbohydrate metabolic process|O-glycan processing|keratan sulfate biosynthetic process|protein N-linked glycosylation via asparagine|glycosaminoglycan metabolic process|keratan sulfate metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|,galactosyltransferase activity|metal ion binding|,10,0.1,0.0179,10,-0.2,0.0367,0,0,0.885,-3.4,2.9
ENSMUSG00000030417,PDCD5,programmed cell death 5,nucleus|cytoplasm|extracellular vesicular exosome|,apoptotic process|positive regulation of apoptotic process|,DNA binding|,8,0,0,10,0,0,0,0,0.885,-2,3.7
ENSMUSG00000029449,RHOF,ras homolog family member F (in filopodia),cytosol|cytoskeleton|plasma membrane|extracellular vesicular exosome|,GTP catabolic process|actin filament organization|small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|,GTPase activity|GTP binding|,10,-0.3,0.0562,10,0.5,0.0683,0,0,0.885,-3.7,3
ENSMUSG00000026981,IL1RN,interleukin 1 receptor antagonist,extracellular space|intracellular|cytoplasm|plasma membrane|extracellular vesicular exosome|,fever generation|negative regulation of cytokine-mediated signaling pathway|chronic inflammatory response to antigenic stimulus|lipid metabolic process|acute-phase response|immune response|female pregnancy|memory|response to organonitrogen compound|negative regulation of glutamate secretion|carboxylic acid metabolic process|insulin secretion|negative regulation of cell migration|response to lipopolysaccharide|negative regulation of heterotypic cell-cell adhesion|response to drug|negative regulation of apoptotic process|positive regulation of JUN kinase activity|negative regulation of membrane potential|response to glucocorticoid|response to interleukin-4|negative regulation of interleukin-1-mediated signaling pathway|,"interleukin-1 receptor binding|interleukin-1, Type I receptor binding|interleukin-1, Type II receptor binding|interleukin-1 receptor antagonist activity|interleukin-1 receptor antagonist activity|interleukin-1 Type I receptor antagonist activity|interleukin-1 Type II receptor antagonist activity|",10,0,0,10,-0.3,0.028,0,0,0.885,-3.6,5.3
ENSMUSG00000074004,B3GNT6,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)",Golgi membrane|membrane|integral component of membrane|,"glycoprotein biosynthetic process|O-glycan processing|O-glycan processing, core 3|post-translational protein modification|cellular protein metabolic process|","galactosyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|",10,0,0,10,-0.1,0.0158,0,0,0.885,-7,2
ENSMUSG00000071054,SAFB,scaffold attachment factor B,nucleus|,"chromatin organization|transcription, DNA-templated|intracellular estrogen receptor signaling pathway|growth|hormone metabolic process|positive regulation of transcription from RNA polymerase II promoter|",nucleotide binding|core promoter binding|chromatin binding|double-stranded DNA binding|protein binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000026527,RGS7,regulator of G-protein signaling 7,nucleus|cytoplasm|cytosol|heterotrimeric G-protein complex|plasma membrane|dendrite terminus|,G-protein coupled receptor signaling pathway|intracellular signal transduction|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|,signal transducer activity|GTPase activator activity|G-protein beta-subunit binding|,10,-0.1,0.0021,10,0,0,0,0,0.885,-7.7,4
ENSMUSG00000023348,TRIP6,thyroid hormone receptor interactor 6,nucleus|cytoplasm|cytoskeleton|plasma membrane|focal adhesion|interleukin-1 receptor complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|release of cytoplasmic sequestered NF-kappaB|positive regulation of cell migration|focal adhesion assembly|",interleukin-1 receptor binding|protein binding|zinc ion binding|kinase binding|poly(A) RNA binding|thyroid hormone receptor binding|,10,0,0,10,0,0,0,0,0.885,-4.4,2.8
ENSMUSG00000059248,9-Sep,septin 9,stress fiber|cytoplasm|microtubule|actin cytoskeleton|perinuclear region of cytoplasm|,GTP catabolic process|cell cycle|protein heterooligomerization|cell division|,GTPase activity|protein binding|GTP binding|,10,0,0,10,0,0,0,0,0.885,-4.9,3
ENSMUSG00000032420,NT5E,"5'-nucleotidase, ecto (CD73)",cytoplasm|plasma membrane|plasma membrane|membrane|anchored component of membrane|extracellular vesicular exosome|,purine nucleobase metabolic process|purine nucleotide catabolic process|AMP catabolic process|pyrimidine nucleobase metabolic process|DNA metabolic process|dephosphorylation|dephosphorylation|dephosphorylation|small molecule metabolic process|adenosine biosynthetic process|pyrimidine nucleoside catabolic process|negative regulation of inflammatory response|nucleobase-containing small molecule metabolic process|,nucleotide binding|5'-nucleotidase activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000030254,RAD18,RAD18 homolog (S. cerevisiae),chromatin|XY body|nucleus|replication fork|,DNA repair|spermatogenesis|response to UV|protein ubiquitination|negative regulation of DNA recombination|,Y-form DNA binding|damaged DNA binding|protein binding|zinc ion binding|ligase activity|polyubiquitin binding|ubiquitin protein ligase binding|,10,0,0,10,-0.1,0.011,0,0,0.885,-4.2,2.9
ENSMUSG00000028826,TMEM57,transmembrane protein 57,nucleus|integral component of membrane|axon|nuclear membrane|neuron projection terminus|synapse|,brain development|biological_process|,molecular_function|,10,0,0,10,1.5,0.416,0,0,0.885,-4.1,6.4
ENSMUSG00000027793,CCNA1,cyclin A1,nucleoplasm|cytosol|microtubule cytoskeleton|,regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|male meiosis I|spermatogenesis|regulation of G2/M transition of mitotic cell cycle|,protein binding|protein kinase binding|,10,0,0,10,0,0,0,0,0.885,-3.4,3
ENSMUSG00000031652,N4BP1,NEDD4 binding protein 1,nucleolus|PML body|,negative regulation of protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV|,protein binding|,10,0,0,10,1.1,0.0128,0,0,0.885,-3.1,3.4
ENSMUSG00000022129,DCT,dopachrome tautomerase,cytosol|integral component of membrane|melanosome membrane|melanosome|,positive regulation of neuroblast proliferation|melanin biosynthetic process from tyrosine|epidermis development|ventricular zone neuroblast division|developmental pigmentation|cell development|oxidation-reduction process|,dopachrome isomerase activity|copper ion binding|oxidoreductase activity|,10,0.1,0.02,10,0,0,0,0,0.885,-2.8,2.8
ENSMUSG00000045438,COX19,cytochrome c oxidase assembly homolog 19 (S. cerevisiae),cytoplasm|cytosol|,None,None,10,0,0,10,0,0,0,0,0.885,-4.2,2
ENSMUSG00000050737,PTGES,prostaglandin E synthase,nuclear envelope lumen|endoplasmic reticulum membrane|membrane|integral component of membrane|perinuclear region of cytoplasm|,prostaglandin biosynthetic process|acute inflammatory response|chronic inflammatory response|prostaglandin metabolic process|signal transduction|negative regulation of cell proliferation|response to organic cyclic compound|arachidonic acid metabolic process|cyclooxygenase pathway|response to lipopolysaccharide|response to retinoic acid|response to cytokine|small molecule metabolic process|response to calcium ion|,glutathione binding|prostaglandin-E synthase activity|prostaglandin-E synthase activity|,10,0,0,10,0,0,0,0,0.885,-2.1,2
ENSMUSG00000059970,HSPA2,heat shock 70kDa protein 2,synaptonemal complex|male germ cell nucleus|nucleus|mitochondrion|cytosol|cell surface|membrane|CatSper complex|extracellular vesicular exosome|blood microparticle|,response to unfolded protein|male meiosis|male meiosis I|spermatid development|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle|protein refolding|synaptonemal complex disassembly|negative regulation of inclusion body assembly|,protein binding|ATP binding|enzyme binding|unfolded protein binding|glycolipid binding|,9,0,0,9,0,0,0,0,0.885,-3.8,2
ENSMUSG00000026193,FN1,fibronectin 1,extracellular region|extracellular region|fibrinogen complex|basement membrane|extracellular space|endoplasmic reticulum-Golgi intermediate compartment|apical plasma membrane|extracellular matrix|extracellular matrix|extracellular matrix|platelet alpha granule lumen|extracellular vesicular exosome|blood microparticle|,angiogenesis|platelet degranulation|acute-phase response|cell-substrate junction assembly|cell adhesion|calcium-independent cell-matrix adhesion|blood coagulation|regulation of cell shape|response to wounding|positive regulation of peptidase activity|peptide cross-linking|extracellular matrix disassembly|platelet activation|extracellular matrix organization|substrate adhesion-dependent cell spreading|leukocyte migration|,protease binding|integrin binding|protein binding|collagen binding|heparin binding|peptidase activator activity|,10,-0.4,0.141,10,0,0,0,0,0.885,-3.7,2.7
ENSMUSG00000039831,ARHGAP29,Rho GTPase activating protein 29,cytosol|,small GTPase mediated signal transduction|Rho protein signal transduction|positive regulation of Rho GTPase activity|regulation of small GTPase mediated signal transduction|,Rho GTPase activator activity|PDZ domain binding|metal ion binding|,10,0,0,10,0.3,0.0675,0,0,0.885,-7,5
ENSMUSG00000001819,HOXD13,homeobox D13,nucleus|,"skeletal system development|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|multicellular organismal development|anterior/posterior pattern specification|male genitalia development|regulation of cell proliferation|embryonic digit morphogenesis|positive regulation of transcription from RNA polymerase II promoter|embryonic hindgut morphogenesis|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|morphogenesis of an epithelial fold|branch elongation of an epithelium|regulation of branching involved in prostate gland morphogenesis|",DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0,0,10,0.1,0.0328,0,0,0.885,-2.1,2
ENSMUSG00000038909,KAT7,K(lysine) acetyltransferase 7,histone acetyltransferase complex|nucleus|nucleoplasm|nucleoplasm|cytoplasm|,"DNA replication|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|",sequence-specific DNA binding transcription factor activity|histone acetyltransferase activity|protein binding|zinc ion binding|,10,0,0,10,1.5,0.366,0,0,0.885,-2,3.6
ENSMUSG00000021709,ERBB2IP,erbb2 interacting protein,basement membrane|nucleus|cytoplasm|plasma membrane|plasma membrane|basal plasma membrane|hemidesmosome|nuclear membrane|,protein targeting|cell cycle|cell adhesion|signal transduction|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|cell growth|intermediate filament cytoskeleton organization|basal protein localization|establishment or maintenance of epithelial cell apical/basal polarity|,ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton|protein binding|,10,0.4,0.0926,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000041075,FZD7,frizzled class receptor 7,cytoplasm|plasma membrane|plasma membrane|integral component of membrane|neuron projection membrane|apical part of cell|,"vasculature development|regulation of transcription, DNA-templated|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|Wnt signaling pathway, calcium modulating pathway|axonogenesis|brain development|gonad development|negative regulation of cell-substrate adhesion|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|stem cell maintenance|neuron differentiation|T cell differentiation in thymus|substrate adhesion-dependent cell spreading|regulation of catenin import into nucleus|non-canonical Wnt signaling pathway via JNK cascade|positive regulation of phosphorylation|negative regulation of ectodermal cell fate specification|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|somatic stem cell division|positive regulation of epithelial cell proliferation involved in wound healing|canonical Wnt signaling pathway|canonical Wnt signaling pathway|mesenchymal to epithelial transition|cellular response to retinoic acid|",G-protein coupled receptor activity|frizzled binding|protein binding|Wnt-protein binding|PDZ domain binding|Wnt-activated receptor activity|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000017466,TIMP2,TIMP metallopeptidase inhibitor 2,extracellular region|basement membrane|extracellular space|cell surface|growth cone|motile cilium|neuronal cell body|extracellular vesicular exosome|,central nervous system development|aging|negative regulation of cell proliferation|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|extracellular matrix disassembly|extracellular matrix organization|regulation of Rap protein signal transduction|response to cytokine|response to drug|positive regulation of MAPK cascade|positive regulation of neuron differentiation|positive regulation of adenylate cyclase activity|negative regulation of proteolysis|negative regulation of mitotic cell cycle|negative regulation of Ras protein signal transduction|cellular response to organic substance|,integrin binding|protein binding|enzyme activator activity|metalloendopeptidase inhibitor activity|metal ion binding|,10,-2,0.147,9,0.4,0.18,0,0,0.885,-6.5,4.9
ENSMUSG00000031209,HEPH,hephaestin,intracellular|plasma membrane|integral component of membrane|basolateral plasma membrane|perinuclear region of cytoplasm|,copper ion transport|iron ion transport|cellular iron ion homeostasis|transmembrane transport|oxidation-reduction process|,ferroxidase activity|copper ion binding|ferrous iron binding|,10,0,0,10,0,0,0,0,0.885,-9,4
ENSMUSG00000020364,ZFP354A,zinc finger protein 354A,intracellular|nucleus|nucleolus|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|nucleolar fragmentation|",nucleic acid binding|DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|metal ion binding|,10,-2,0.156,9,0.4,0.155,0,0,0.885,-6.5,3
ENSMUSG00000050222,IL17D,interleukin 17D,extracellular space|,inflammatory response|,cytokine activity|,10,0,0,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000031511,ARHGEF7,Rho guanine nucleotide exchange factor (GEF) 7,ruffle|cytosol|focal adhesion|cell cortex|lamellipodium|neuron projection|neuronal cell body|protein complex|,signal transduction|epidermal growth factor receptor signaling pathway|small GTPase mediated signal transduction|nervous system development|lamellipodium assembly|positive regulation of Rho GTPase activity|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of GTPase activity|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|protein binding|protein kinase binding|,10,0,0,10,0,0,0,0,0.885,-7.6,4.5
ENSMUSG00000027835,PDCD10,programmed cell death 10,Golgi membrane|cytosol|plasma membrane|extracellular vesicular exosome|,angiogenesis|apoptotic process|positive regulation of cell proliferation|negative regulation of apoptotic process|positive regulation of MAP kinase activity|,protein binding|protein homodimerization activity|protein N-terminus binding|,10,0,0,10,-1.7,0.562,0,0,0.885,-5.3,1.9
ENSMUSG00000091956,C2CD4B,C2 calcium-dependent domain containing 4B,nucleolus|focal adhesion|,None,None,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000079563,PGLYRP2,peptidoglycan recognition protein 2,intracellular|membrane|extracellular vesicular exosome|,peptide amidation|pattern recognition receptor signaling pathway|peptidoglycan catabolic process|detection of bacterium|negative regulation of interferon-gamma production|negative regulation of natural killer cell differentiation involved in immune response|growth of symbiont in host|innate immune response|defense response to Gram-positive bacterium|,zinc ion binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|peptidoglycan binding|,10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000043811,RTN4R,reticulon 4 receptor,endoplasmic reticulum|plasma membrane|cell surface|anchored component of membrane|,axonogenesis|neurotrophin TRK receptor signaling pathway|regulation of axonogenesis|negative regulation of axonogenesis|,receptor activity|protein binding|,10,0,0,10,0,0,0,0,0.885,-6.9,4.3
ENSMUSG00000079440,ALPI,"alkaline phosphatase, intestinal",plasma membrane|integral component of membrane|anchored component of membrane|,dephosphorylation|,magnesium ion binding|protease binding|alkaline phosphatase activity|alkaline phosphatase activity|zinc ion binding|,10,0.5,0.128,10,-0.5,0.131,0,0,0.885,-5.8,4.3
ENSMUSG00000032591,MST1,macrophage stimulating 1 (hepatocyte growth factor-like),extracellular vesicular exosome|,proteolysis|biological_process|,molecular_function|serine-type endopeptidase activity|,10,-0.1,0.0167,10,0,0,0,0,0.885,-3.4,3.1
ENSMUSG00000053226,DAND5,"DAN domain family member 5, BMP antagonist",extracellular region|,determination of left/right asymmetry in lateral mesoderm|ventricular septum development|atrial septum development|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|sequestering of nodal from receptor via nodal binding|determination of heart left/right asymmetry|negative regulation of nodal signaling pathway|,morphogen activity|,10,0,0,10,0,0,0,0,0.885,-5.7,2.5
ENSMUSG00000015312,GADD45B,"growth arrest and DNA-damage-inducible, beta",nucleus|cytoplasm|,activation of MAPKKK activity|activation of MAPKK activity|negative regulation of protein kinase activity|apoptotic process|response to stress|multicellular organismal development|cell differentiation|positive regulation of apoptotic process|positive regulation of JNK cascade|regulation of cell cycle|positive regulation of p38MAPK cascade|,protein binding|,10,-0.4,0.149,10,0,0,0,0,0.885,-3.4,2.2
ENSMUSG00000026024,ALS2,amyotrophic lateral sclerosis 2 (juvenile),ruffle|early endosome|centrosome|cytosol|postsynaptic density|lamellipodium|dendrite|growth cone|vesicle|dendritic spine|protein complex|,"behavioral fear response|receptor recycling|response to oxidative stress|endosome organization|endosome organization|neuromuscular junction development|locomotory behavior|protein localization|cell death|vesicle organization|endosomal transport|positive regulation of Rab GTPase activity|positive regulation of Ran GTPase activity|positive regulation of Rac GTPase activity|positive regulation of Rac protein signal transduction|synaptic transmission, glutamatergic|positive regulation of protein kinase activity|neuron projection morphogenesis|regulation of endosome size|positive regulation of protein serine/threonine kinase activity|",guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity|protein binding|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|Rab GTPase binding|Rac guanyl-nucleotide exchange factor activity|protein homodimerization activity|protein serine/threonine kinase activator activity|,10,0,0,10,-0.2,0.0908,0,0,0.885,-3.5,2
ENSMUSG00000030595,NFKBIB,"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta",nucleus|cytosol|,"toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transcription, DNA-templated|signal transduction|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|innate immune response|positive regulation of NF-kappaB transcription factor activity|",transcription coactivator activity|signal transducer activity|protein binding|,10,0,0,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000028341,NR4A3,"nuclear receptor subfamily 4, group A, member 3",nucleus|nucleoplasm|transcription factor complex|,mesoderm formation|transcription initiation from RNA polymerase II promoter|axon guidance|biological_process|gene expression|hippocampus development|intracellular receptor signaling pathway|intracellular receptor signaling pathway|adult behavior|organ regeneration|response to hydrogen peroxide|steroid hormone mediated signaling pathway|response to peptide hormone|negative regulation of neuron apoptotic process|positive regulation of cell cycle|positive regulation of transcription from RNA polymerase II promoter|semicircular canal morphogenesis|neuromuscular process controlling balance|vestibular reflex|positive regulation of leukocyte apoptotic process|,RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding|sequence-specific DNA binding|,10,0,0,10,0.5,0.372,0,0,0.885,-2.7,3.8
ENSMUSG00000051335,GFOD1,glucose-fructose oxidoreductase domain containing 1,extracellular region|,oxidation-reduction process|,oxidoreductase activity|,10,0,0,10,0,0,0,0,0.885,-4.9,2
ENSMUSG00000066090,INSL5,insulin-like 5,cellular_component|extracellular region|,biological_process|,hormone activity|,10,0,0,10,0,0,0,0,0.885,-2.8,2
ENSMUSG00000053870,FPGT,fucose-1-phosphate guanylyltransferase,cytoplasm|,fucose metabolic process|,catalytic activity|GTP binding|fucose-1-phosphate guanylyltransferase activity|,10,-0.1,0.0114,10,0,0,0,0,0.885,-6.7,3.6
ENSMUSG00000076439,MOG,myelin oligodendrocyte glycoprotein,plasma membrane|integral component of membrane|,cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway|,None,9,3.5,0.94,9,-1,0.436,0,0,0.885,-5.7,8.2
ENSMUSG00000031165,WAS,Wiskott-Aldrich syndrome,cytosol|vesicle membrane|actin cytoskeleton|extracellular vesicular exosome|,protein complex assembly|defense response|immune response|blood coagulation|actin polymerization or depolymerization|epidermis development|endosomal transport|actin filament polymerization|actin filament-based movement|Fc-gamma receptor signaling pathway involved in phagocytosis|T cell activation|innate immune response|regulation of catalytic activity|T cell receptor signaling pathway|positive regulation of Arp2/3 complex-mediated actin nucleation|,actin binding|small GTPase regulator activity|protein binding|identical protein binding|,10,-0.6,0.13,10,0.3,0.247,0,0,0.885,-5.8,2
ENSMUSG00000026790,ODF2,outer dense fiber of sperm tails 2,spindle pole|outer dense fiber|nucleus|centrosome|centriole|cytosol|microtubule|,G2/M transition of mitotic cell cycle|mitotic cell cycle|multicellular organismal development|spermatid development|,structural molecule activity|protein binding|,9,1.3,0.273,9,-0.3,0.119,0,0,0.885,-7.7,5
ENSMUSG00000027479,MAPRE1,"microtubule-associated protein, RP/EB family, member 1",cytoplasm|Golgi apparatus|centrosome|spindle|cytosol|microtubule|cytoplasmic microtubule|cortical microtubule cytoskeleton|cell projection membrane|microtubule plus-end|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic nuclear division|cell proliferation|negative regulation of microtubule polymerization|protein localization to microtubule|,protein binding|protein C-terminus binding|poly(A) RNA binding|microtubule plus-end binding|,9,0,0,10,0,0,0,0,0.885,-2,5.4
ENSMUSG00000010044,ZMYND10,"zinc finger, MYND-type containing 10",cytoplasm|centriolar satellite|,outer dynein arm assembly|inner dynein arm assembly|motile cilium assembly|,protein binding|metal ion binding|,10,-0.5,0.125,10,0,0,0,0,0.885,-6,3.5
ENSMUSG00000033569,BAI3,brain-specific angiogenesis inhibitor 3,plasma membrane|integral component of membrane|,G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|negative regulation of angiogenesis|,G-protein coupled receptor activity|,10,0,0,10,0,0,0,0,0.885,-3.8,2.4
ENSMUSG00000005078,JKAMP,JNK1/MAPK8-associated membrane protein,endoplasmic reticulum membrane|integral component of membrane|,response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|,ubiquitin protein ligase binding|,10,0,0,10,0,0,0,0,0.885,-3.5,3.7
ENSMUSG00000021707,DHFR,dihydrofolate reductase,None,None,None,10,-3.7,0.965,10,0,0,0,0,0.885,-6.9,3
ENSMUSG00000034118,TPST1,tyrosylprotein sulfotransferase 1,Golgi membrane|membrane|integral component of membrane|,peptidyl-tyrosine sulfation|inflammatory response|,protein-tyrosine sulfotransferase activity|,10,0,0,10,0,0,0,0,0.885,-8.1,3
ENSMUSG00000021986,AMER2,APC membrane recruitment protein 2,plasma membrane|,ectoderm development|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|,"protein binding|phosphatidylinositol-4,5-bisphosphate binding|",10,1.1,0.506,10,0,0,0,0,0.885,-2,3.6
ENSMUSG00000004530,CORO1C,"coronin, actin binding protein, 1C",cytoplasm|plasma membrane|actin cytoskeleton|lamellipodium|,phagocytosis|signal transduction|actin cytoskeleton organization|,actin filament binding|,10,0,0,10,0,0,0,0,0.885,-7.9,3.9
ENSMUSG00000021136,SMOC1,SPARC related modular calcium binding 1,basement membrane|,eye development|signal transduction|positive regulation of cell-substrate adhesion|cell differentiation|extracellular matrix organization|regulation of osteoblast differentiation|limb development|,calcium ion binding|protein binding|extracellular matrix binding|,10,-0.5,0.224,10,0,0,0,0,0.885,-5.1,2
ENSMUSG00000028654,MYCL,v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog,nucleus|,"regulation of transcription, DNA-templated|",DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein dimerization activity|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000093809,BCL2A1A,B cell leukemia/lymphoma 2 related protein A1a,cytoplasm|mitochondrial outer membrane|,B cell homeostasis|negative regulation of B cell apoptotic process|apoptotic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of apoptotic process|negative regulation of apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein binding|protein homodimerization activity|protein heterodimerization activity|protein heterodimerization activity|BH domain binding|,9,-1.8,0.667,9,0,0,0,0,0.885,-9.4,2
ENSMUSG00000009097,TBX1,T-box 1,nucleus|,"angiogenesis|blood vessel development|cell fate specification|neural crest cell migration|positive regulation of protein phosphorylation|lymph vessel development|blood vessel remodeling|positive regulation of mesenchymal cell proliferation|heart morphogenesis|outflow tract septum morphogenesis|outflow tract morphogenesis|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|pattern specification process|mesoderm development|heart development|muscle organ development|sensory perception of sound|cell proliferation|positive regulation of cell proliferation|anterior/posterior pattern specification|vagus nerve morphogenesis|epithelial cell differentiation|thyroid gland development|social behavior|aorta morphogenesis|ear morphogenesis|inner ear morphogenesis|outer ear morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|muscle cell fate commitment|positive regulation of MAPK cascade|tongue morphogenesis|cellular response to fibroblast growth factor stimulus|negative regulation of cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|retinoic acid receptor signaling pathway|blood vessel morphogenesis|thymus development|muscle organ morphogenesis|embryonic cranial skeleton morphogenesis|embryonic viscerocranium morphogenesis|semicircular canal morphogenesis|artery morphogenesis|positive regulation of epithelial cell proliferation|parathyroid gland development|soft palate development|pharyngeal system development|face morphogenesis|muscle tissue morphogenesis|coronary artery morphogenesis|enamel mineralization|cellular response to retinoic acid|otic vesicle morphogenesis|positive regulation of secondary heart field cardioblast proliferation|cochlea morphogenesis|mesenchymal cell apoptotic process|regulation of organ morphogenesis|positive regulation of tongue muscle cell differentiation|negative regulation of mesenchymal cell apoptotic process|",DNA binding|protein homodimerization activity|sequence-specific DNA binding|protein dimerization activity|,10,0,0,10,0,0,0,0,0.885,-3.6,3.6
ENSMUSG00000024401,TNF,tumor necrosis factor,phagocytic cup|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|external side of plasma membrane|cell surface|membrane raft|recycling endosome|,"protein import into nucleus, translocation|negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|activation of MAPKKK activity|activation of MAPK activity|response to hypoxia|cell activation|positive regulation of cytokine production|positive regulation of protein phosphorylation|negative regulation of L-glutamate transport|chronic inflammatory response to antigenic stimulus|negative regulation of cytokine secretion involved in immune response|positive regulation of chronic inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|skeletal muscle contraction|glucose metabolic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|transformed cell apoptotic process|inflammatory response|humoral immune response|JNK cascade|negative regulation of cell proliferation|extrinsic apoptotic signaling pathway via death domain receptors|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|cellular amino acid biosynthetic process|response to mechanical stimulus|response to virus|response to salt stress|organ morphogenesis|positive regulation of gene expression|negative regulation of gene expression|negative regulation of alkaline phosphatase activity|negative regulation of lipid storage|response to activity|calcium-mediated signaling|extracellular matrix organization|osteoclast differentiation|sequestering of triglyceride|positive regulation of protein complex assembly|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|negative regulation of interleukin-6 production|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|receptor biosynthetic process|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|positive regulation of heterotypic cell-cell adhesion|positive regulation of NF-kappaB import into nucleus|response to drug|positive regulation of apoptotic process|positive regulation of programmed cell death|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of protein complex disassembly|positive regulation of protein complex disassembly|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|negative regulation of growth of symbiont in host|negative regulation of viral genome replication|positive regulation of chemokine biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of nitric oxide biosynthetic process|negative regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of mitosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translational initiation by iron|negative regulation of glucose import|positive regulation of JNK cascade|embryonic digestive tract development|positive regulation of smooth muscle cell proliferation|positive regulation of cytokine secretion|regulation of insulin secretion|positive regulation of synaptic transmission|defense response to Gram-positive bacterium|leukocyte tethering or rolling|negative regulation of lipid catabolic process|regulation of immunoglobulin secretion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein transport|response to glucocorticoid|positive regulation of NFAT protein import into nucleus|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|positive regulation of vitamin D biosynthetic process|positive regulation of calcidiol 1-monooxygenase activity|epithelial cell proliferation involved in salivary gland morphogenesis|regulation of branching involved in salivary gland morphogenesis|negative regulation of branching involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|cellular response to amino acid stimulus|cellular response to nicotine|cellular response to organic cyclic compound|positive regulation of mononuclear cell migration|positive regulation of podosome assembly|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to cell surface|positive regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|",protease binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|identical protein binding|transcription regulatory region DNA binding|,10,-1.8,0.997,10,0,0,0,0,0.885,-5.7,2.2
ENSMUSG00000015950,NCF1,neutrophil cytosolic factor 1,rough endoplasmic reticulum|Golgi apparatus|cytosol|cytosol|extrinsic component of membrane|dendrite|phagolysosome|NADPH oxidase complex|NADPH oxidase complex|neuronal cell body|,"response to yeast|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|respiratory burst involved in defense response|protein targeting to membrane|leukotriene metabolic process|superoxide metabolic process|apoptotic process|inflammatory response|cellular defense response|cell proliferation|superoxide anion generation|superoxide anion generation|antigen processing and presentation of exogenous peptide antigen via MHC class I|innate immune response|respiratory burst|negative regulation of smooth muscle contraction|hydrogen peroxide biosynthetic process|interaction with host|oxidation-reduction process|oxidation-reduction process|neutrophil mediated killing of gram-positive bacterium|neutrophil mediated killing of fungus|phagosome maturation|","protein binding|electron carrier activity|superoxide-generating NADPH oxidase activity|SH3 domain binding|phosphatidylinositol binding|phosphatidylinositol-3,4-bisphosphate binding|",10,0.8,0.619,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000034101,CTNND1,"catenin (cadherin-associated protein), delta 1",nucleus|cytoplasm|cytosol|plasma membrane|plasma membrane|plasma membrane|cell-cell junction|zonula adherens|lamellipodium|growth cone|midbody|dendritic spine|synapse|extracellular vesicular exosome|,"morphogenesis of a polarized epithelium|transcription, DNA-templated|regulation of transcription, DNA-templated|cell adhesion|brain development|salivary gland morphogenesis|Wnt signaling pathway|single organismal cell-cell adhesion|keratinocyte differentiation|cell junction assembly|adherens junction organization|cell-cell junction organization|epithelial cell differentiation involved in salivary gland development|negative regulation of canonical Wnt signaling pathway|",receptor binding|protein binding|protein kinase binding|protein phosphatase binding|protein domain specific binding|cadherin binding|,9,-0.7,0.2,9,0.8,0.885,0,0,0.885,-3.3,5.7
ENSMUSG00000059939,9430015G10RIK,RIKEN cDNA 9430015G10 gene,cellular_component|,biological_process|,molecular_function|,10,0,0,10,0,0,0,0,0.885,-2.5,1.7
ENSMUSG00000026928,CARD9,"caspase recruitment domain family, member 9",cytoplasm|,"response to fungus|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|response to drug|regulation of tumor necrosis factor biosynthetic process|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|regulation of interleukin-2 biosynthetic process|innate immune response|regulation of interleukin-6 biosynthetic process|positive regulation of JNK cascade|defense response to Gram-positive bacterium|defense response to virus|nucleotide-binding oligomerization domain containing signaling pathway|",protein homodimerization activity|CARD domain binding|,10,4.8,1.15,10,0,0,0,0,0.885,-7.3,11
ENSMUSG00000062591,TUBB4A,"tubulin, beta 4A class IVa",nucleus|cytosol|microtubule|cilium|internode region of axon|neuronal cell body|myelin sheath|,G2/M transition of mitotic cell cycle|mitotic cell cycle|GTP catabolic process|protein folding|microtubule-based process|cellular protein metabolic process|'de novo' posttranslational protein folding|protein polymerization|,GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|,10,0,0,10,0,0,0,0,0.885,-2.7,2.3
ENSMUSG00000048388,FAM171B,"family with sequence similarity 171, member B",integral component of membrane|,None,DNA binding|,10,0,0,10,0.4,0.0543,0,0,0.885,-2.8,5.1
ENSMUSG00000017485,TOP2B,topoisomerase (DNA) II beta 180kDa,heterochromatin|nucleus|nucleoplasm|cytoplasm|cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|,resolution of meiotic recombination intermediates|sister chromatid segregation|neuron migration|ATP catabolic process|ATP catabolic process|DNA topological change|DNA unwinding involved in DNA replication|mitotic recombination|axonogenesis|forebrain development|mitotic DNA integrity checkpoint|,"chromatin binding|DNA topoisomerase type II (ATP-hydrolyzing) activity|protein kinase C binding|ATP binding|protein C-terminus binding|DNA binding, bending|enzyme binding|histone deacetylase binding|metal ion binding|protein heterodimerization activity|",10,0,0,9,1.1,0.186,0,0,0.885,-6.6,5
ENSMUSG00000036850,MRPL41,mitochondrial ribosomal protein L41,mitochondrion|mitochondrial large ribosomal subunit|ribonucleoprotein complex|,translation|apoptotic process|cell cycle|,structural constituent of ribosome|protein binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-5.6,6
ENSMUSG00000022967,IFNAR1,"interferon (alpha, beta and omega) receptor 1",plasma membrane|integral component of plasma membrane|,cell surface receptor signaling pathway|JAK-STAT cascade|response to virus|cytokine-mediated signaling pathway|positive regulation of interferon-gamma production|T cell activation|type I interferon biosynthetic process|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|,type I interferon receptor activity|protein binding|,9,-0.5,0.117,9,0,0,0,0,0.885,-6,2
ENSMUSG00000034330,PLCG2,"phospholipase C, gamma 2 (phosphatidylinositol-specific)",cytosol|plasma membrane|plasma membrane|extracellular vesicular exosome|,follicular B cell differentiation|phosphatidylinositol biosynthetic process|blood coagulation|phospholipid catabolic process|regulation of gene expression|Wnt signaling pathway|calcium-mediated signaling|platelet activation|B cell differentiation|activation of store-operated calcium channel activity|response to lipopolysaccharide|inositol trisphosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of programmed cell death|inositol phosphate metabolic process|small molecule metabolic process|innate immune response|T cell receptor signaling pathway|B cell receptor signaling pathway|release of sequestered calcium ion into cytosol|,phosphatidylinositol phospholipase C activity|phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|protein binding|,10,0,0,10,0,0,0,0,0.885,-9,3
ENSMUSG00000092345,GM20503,N/A,None,None,None,1,0,0,1,-0.2,0.00809,0,0,0.885,-2,1.8
ENSMUSG00000066043,PHACTR4,phosphatase and actin regulator 4,cytoplasm|lamellipodium|,neural crest cell migration|neural tube closure|Rho protein signal transduction|actin cytoskeleton organization|positive regulation of catalytic activity|enteric nervous system development|regulation of cell cycle|closure of optic fissure|negative regulation of integrin-mediated signaling pathway|,actin binding|protein phosphatase 1 binding|protein phosphatase type 1 activator activity|,10,0.2,0.0707,10,0,0,0,0,0.885,-3.7,3.4
ENSMUSG00000038060,DLEC1,deleted in lung and esophageal cancer 1,cytoplasm|,negative regulation of cell proliferation|,molecular_function|,10,-0.2,0.0307,10,0,0,0,0,0.885,-4.1,3.8
ENSMUSG00000021747,4930452B06RIK,RIKEN cDNA 4930452B06 gene,cellular_component|,biological_process|,molecular_function|,1,0,0,0,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000029020,MFN2,mitofusin 2,mitochondrion|mitochondrial outer membrane|cytosol|microtubule cytoskeleton|integral component of membrane|intrinsic component of mitochondrial outer membrane|,blastocyst formation|GTP catabolic process|protein targeting to mitochondrion|mitochondrial membrane organization|blood coagulation|mitochondrial fusion|mitochondrial fusion|mitochondrial fusion|cell death|negative regulation of Ras protein signal transduction|camera-type eye morphogenesis|negative regulation of smooth muscle cell proliferation|mitochondrion localization|,GTPase activity|protein binding|GTP binding|ubiquitin protein ligase binding|,9,0.2,0.0326,10,-0.5,0.212,0,0,0.885,-5.7,2.9
ENSMUSG00000018509,CENPV,centromere protein V,kinetochore|condensed chromosome kinetochore|nucleus|cytoplasm|microtubule cytoskeleton|spindle midzone|,ameboidal cell migration|mitotic nuclear division|centromeric heterochromatin assembly|positive regulation of cytokinesis|regulation of chromosome organization|centromere complex assembly|,molecular_function|carbon-sulfur lyase activity|,10,-0.5,0.149,10,4.1,0.579,0,0,0.885,-5.3,8.7
ENSMUSG00000031391,L1CAM,L1 cell adhesion molecule,plasma membrane|external side of plasma membrane|integral component of membrane|presynaptic membrane|terminal bouton|,chemotaxis|cell adhesion|homophilic cell adhesion|heterophilic cell-cell adhesion|leukocyte cell-cell adhesion|cell surface receptor signaling pathway|nervous system development|axon guidance|blood coagulation|cell death|positive regulation of cell-cell adhesion|cell-cell adhesion mediated by integrin|homotypic cell-cell adhesion|positive regulation of calcium-mediated signaling|leukocyte migration|,integrin binding|sialic acid binding|identical protein binding|protein self-association|,10,0,0,10,0,0,0,0,0.885,-3.1,2.6
ENSMUSG00000000384,TBRG4,transforming growth factor beta regulator 4,mitochondrion|,mitotic G1 phase|protein phosphorylation|cell cycle arrest|positive regulation of cell proliferation|cellular respiration|,protein kinase activity|poly(A) RNA binding|,10,-0.3,0.0859,10,0,0,0,0,0.885,-3.9,2.5
ENSMUSG00000030994,D7ERTD443E,"DNA segment, Chr 7, ERATO Doi 443, expressed",cytoplasm|centrosome|cytoskeleton|actin cytoskeleton|,cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|response to UV|response to ionizing radiation|negative regulation of cell growth|protein stabilization|,histone deacetylase binding|,10,0,0,10,0,0,0,0,0.885,-3.3,2.5
ENSMUSG00000031197,VBP1,von Hippel-Lindau binding protein 1,nucleus|cytoplasm|prefoldin complex|intracellular membrane-bounded organelle|,protein folding|cellular protein metabolic process|'de novo' posttranslational protein folding|,protein binding|unfolded protein binding|,10,-0.2,0.0256,10,0,0,0,0,0.885,-7.5,5.2
ENSMUSG00000000326,COMT,catechol-O-methyltransferase,mitochondrion|cytosol|plasma membrane|membrane|integral component of membrane|extracellular vesicular exosome|,xenobiotic metabolic process|synaptic transmission|female pregnancy|learning|estrogen metabolic process|response to organic cyclic compound|methylation|response to lipopolysaccharide|neurotransmitter catabolic process|neurotransmitter biosynthetic process|dopamine catabolic process|response to drug|small molecule metabolic process|negative regulation of dopamine metabolic process|response to pain|multicellular organismal reproductive process|negative regulation of smooth muscle cell proliferation|positive regulation of homocysteine metabolic process|,magnesium ion binding|O-methyltransferase activity|catechol O-methyltransferase activity|,10,0,0,10,-0.4,0.273,0,0,0.885,-3.7,1.9
ENSMUSG00000039357,FUT11,"fucosyltransferase 11 (alpha (1,3) fucosyltransferase)",integral component of membrane|Golgi cisterna membrane|extracellular vesicular exosome|,protein glycosylation|fucosylation|,alpha-(1->3)-fucosyltransferase activity|,10,-0.9,0.164,10,0,0,0,0,0.885,-3.3,3.1
ENSMUSG00000075232,AMD1,adenosylmethionine decarboxylase 1,cytosol|,S-adenosylmethioninamine biosynthetic process|polyamine metabolic process|spermine biosynthetic process|spermidine biosynthetic process|cellular nitrogen compound metabolic process|small molecule metabolic process|,adenosylmethionine decarboxylase activity|,9,-4.1,1.89,9,-0.1,0.00084,0,0,0.885,-8.6,7
ENSMUSG00000032375,APH1B,APH1B gamma secretase subunit,plasma membrane|integral component of membrane|transport vesicle|,Notch signaling pathway|Notch receptor processing|protein processing|membrane protein intracellular domain proteolysis|positive regulation of apoptotic process|positive regulation of catalytic activity|neurotrophin TRK receptor signaling pathway|apoptotic signaling pathway|,protein binding|peptidase activity|,0,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000037605,LPHN3,latrophilin 3,plasma membrane|integral component of membrane|,G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|,G-protein coupled receptor activity|carbohydrate binding|,10,-0.1,0.0113,10,0,0,0,0,0.885,-4.8,3
ENSMUSG00000036111,LMO1,LIM domain only 1 (rhombotin 1),nucleus|,negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|,zinc ion binding|,10,0,0,10,0,0,0,0,0.885,-5.7,3
ENSMUSG00000074852,HPSE2,heparanase 2 (inactive),proteinaceous extracellular matrix|intracellular|plasma membrane|,carbohydrate metabolic process|glycosaminoglycan catabolic process|biological_process|glycosaminoglycan metabolic process|small molecule metabolic process|,heparanase activity|heparan sulfate proteoglycan binding|,10,-2.3,0.268,10,0.2,0.0366,0,0,0.885,-6.4,3.3
ENSMUSG00000029238,CLOCK,clock circadian regulator,nucleus|transcription factor complex|chromosome|cytosol|chromatoid body|intracellular membrane-bounded organelle|,"DNA damage checkpoint|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|signal transduction|spermatogenesis|circadian rhythm|photoperiodism|histone acetylation|histone acetylation|circadian regulation of gene expression|circadian regulation of gene expression|circadian regulation of gene expression|regulation of hair cycle|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of insulin secretion|positive regulation of NF-kappaB transcription factor activity|response to redox state|cellular response to ionizing radiation|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|histone acetyltransferase activity|signal transducer activity|protein binding|chromatin DNA binding|sequence-specific DNA binding|protein dimerization activity|E-box binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000024824,RAD9A,RAD9 homolog A (S. pombe),nucleus|nucleoplasm|cytoplasm|checkpoint clamp complex|,"DNA replication checkpoint|DNA damage checkpoint|DNA catabolic process, exonucleolytic|DNA replication|DNA repair|cellular response to DNA damage stimulus|intra-S DNA damage checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|",protein binding|3'-5' exonuclease activity|exodeoxyribonuclease III activity|SH3 domain binding|enzyme binding|protein kinase binding|histone deacetylase binding|,10,0,0,10,5.3,0.632,0,0,0.885,-5.9,10.3
ENSMUSG00000029640,USP12,ubiquitin specific peptidase 12,cellular_component|,ubiquitin-dependent protein catabolic process|protein deubiquitination|,cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|protein binding|,10,0,0,10,1.3,0.392,0,0,0.885,-3.4,4
ENSMUSG00000020484,XBP1,X-box binding protein 1,nucleus|nucleoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|immune response|activation of signaling protein activity involved in unfolded protein response|endoplasmic reticulum unfolded protein response|exocrine pancreas development|response to drug|cellular protein metabolic process|response to electrical stimulus|serotonin secretion, neurotransmission|epithelial cell maturation involved in salivary gland development|cellular response to antibiotic|positive regulation of endoplasmic reticulum unfolded protein response|",DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0,0,10,0,0,0,0,0.885,-8.2,3
ENSMUSG00000035674,NDUFA3,"NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa",mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|integral component of membrane|,"mitochondrial electron transport, NADH to ubiquinone|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|",NADH dehydrogenase (ubiquinone) activity|,10,0,0,10,0,0,0,0,0.885,-5.2,3.7
ENSMUSG00000062906,HDAC10,histone deacetylase 10,histone deacetylase complex|nucleus|nucleoplasm|nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deacetylation|Notch signaling pathway|oligodendrocyte development|chromatin modification|histone deacetylation|negative regulation of transcription, DNA-templated|histone H3 deacetylation|histone H4 deacetylation|",histone deacetylase activity|protein binding|enzyme binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000000214,TH,tyrosine hydroxylase,nucleus|cytoplasm|mitochondrion|smooth endoplasmic reticulum|cytosol|synaptic vesicle|cytoplasmic side of plasma membrane|dendrite|cytoplasmic vesicle|melanosome membrane|neuron projection|terminal bouton|perikaryon|,"response to hypoxia|synaptic transmission, dopaminergic|response to amphetamine|heart morphogenesis|dopamine biosynthetic process from tyrosine|fatty acid metabolic process|sphingolipid metabolic process|heart development|visual perception|sensory perception of sound|learning|memory|mating behavior|locomotory behavior|regulation of heart contraction|response to water deprivation|response to light stimulus|response to herbicide|response to salt stress|anatomical structure morphogenesis|organ morphogenesis|response to zinc ion|multicellular organismal aging|response to activity|synaptic vesicle amine transport|glycoside metabolic process|phthalate metabolic process|cerebral cortex development|response to nutrient levels|response to estradiol|response to lipopolysaccharide|isoquinoline alkaloid metabolic process|cellular nitrogen compound metabolic process|social behavior|cellular response to drug|neurotransmitter biosynthetic process|terpene metabolic process|dopamine biosynthetic process|epinephrine biosynthetic process|norepinephrine biosynthetic process|catecholamine biosynthetic process|eye photoreceptor cell development|circadian sleep/wake cycle|eating behavior|response to peptide hormone|pigmentation|small molecule metabolic process|response to ethanol|response to ether|response to pyrethroid|embryonic camera-type eye morphogenesis|response to corticosterone|response to electrical stimulus|phytoalexin metabolic process|oxidation-reduction process|cellular response to manganese ion|cellular response to nicotine|cellular response to glucose stimulus|cellular response to growth factor stimulus|",tyrosine 3-monooxygenase activity|tyrosine 3-monooxygenase activity|protein binding|ferrous iron binding|ferric iron binding|amino acid binding|oxygen binding|protein domain specific binding|tetrahydrobiopterin binding|dopamine binding|,10,-0.1,0.000827,10,0.2,0.0225,0,0,0.885,-9.9,4
ENSMUSG00000054630,UGT2B5,"UDP glucuronosyltransferase 2 family, polypeptide B5",mitochondrial inner membrane|endoplasmic reticulum|membrane|integral component of membrane|intracellular membrane-bounded organelle|,metabolic process|,"glucuronosyltransferase activity|transferase activity|transferase activity, transferring glycosyl groups|transferase activity, transferring hexosyl groups|",10,0,0,10,1.1,0.654,0,0,0.885,-1.4,2.8
ENSMUSG00000038641,AKR1D1,"aldo-keto reductase family 1, member D1",cytosol|cytosol|extracellular vesicular exosome|,bile acid biosynthetic process|bile acid biosynthetic process|cholesterol catabolic process|digestion|bile acid metabolic process|C21-steroid hormone metabolic process|androgen metabolic process|bile acid catabolic process|small molecule metabolic process|oxidation-reduction process|,steroid binding|delta4-3-oxosteroid 5beta-reductase activity|,9,0.2,0.039,10,0,0,0,0,0.885,-3.7,2.8
ENSMUSG00000028717,TAL1,T-cell acute lymphocytic leukemia 1,histone deacetylase complex|nuclear chromatin|nucleus|transcription factor complex|Lsd1/2 complex|,"negative regulation of transcription from RNA polymerase II promoter|angiogenesis|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|locomotory behavior|spinal cord association neuron differentiation|hemopoiesis|erythrocyte differentiation|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|basophil differentiation|positive regulation of protein complex assembly|embryonic hemopoiesis|megakaryocyte development|regulation of cell proliferation|erythrocyte maturation|cell fate commitment|positive regulation of erythrocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of chromatin assembly or disassembly|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cell division|astrocyte fate commitment|definitive hemopoiesis|hemangioblast cell differentiation|hematopoietic stem cell differentiation|regulation of mast cell differentiation|regulation of stem cell maintenance|",RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|enzyme binding|histone deacetylase binding|transcription regulatory region DNA binding|protein heterodimerization activity|E-box binding|,10,0,0,10,0,0,0,0,0.885,-3.3,2.4
ENSMUSG00000035239,NEU3,sialidase 3 (membrane sialidase),plasma membrane|plasma membrane|integral component of plasma membrane|,carbohydrate metabolic process|sphingolipid metabolic process|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|small molecule metabolic process|,exo-alpha-sialidase activity|alpha-sialidase activity|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|,10,0,0,10,0,0,0,0,0.885,-8.8,3
ENSMUSG00000015812,GNRH1,gonadotropin-releasing hormone 1 (luteinizing-releasing hormone),extracellular region|extracellular space|,signal transduction|cell-cell signaling|multicellular organismal development|female pregnancy|negative regulation of cell proliferation|regulation of gene expression|response to corticosteroid|ovulation cycle|negative regulation of apoptotic process|response to ethanol|regulation of ovarian follicle development|negative regulation of neuron migration|,hormone activity|gonadotropin hormone-releasing hormone activity|,10,0,0,10,0,0,0,0,0.885,-5.1,2.9
ENSMUSG00000011256,ADAM19,ADAM metallopeptidase domain 19,integral component of membrane|,membrane protein ectodomain proteolysis|heart development|,metalloendopeptidase activity|zinc ion binding|SH3 domain binding|,10,0,0,10,0,0,0,0,0.885,-1.7,1.7
ENSMUSG00000029772,AHCYL2,adenosylhomocysteinase-like 2,None,one-carbon metabolic process|,adenosylhomocysteinase activity|,10,0,0,10,0,0,0,0,0.885,-2.5,2.5
ENSMUSG00000034501,PCNXL4,pecanex-like 4 (Drosophila),integral component of membrane|,None,None,10,-0.1,0.0162,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000032579,HEMK1,HemK methyltransferase family member 1,mitochondrion|,DNA methylation|protein methylation|,DNA binding|N-methyltransferase activity|protein methyltransferase activity|,0,0,0,1,0,0,0,0,0.885,-1.8,2
ENSMUSG00000076746,TCRG-V6,"T cell receptor gamma, variable 6",None,None,None,10,0.3,0.0674,10,0,0,0,0,0.885,-2,2.7
ENSMUSG00000029171,PGM1,phosphoglucomutase 1,cytoplasm|cytosol|cytosol|extracellular vesicular exosome|,carbohydrate metabolic process|glycogen biosynthetic process|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|galactose catabolic process|galactose catabolic process|small molecule metabolic process|,magnesium ion binding|phosphoglucomutase activity|phosphoglucomutase activity|,10,0,0,10,0.4,0.258,0,0,0.885,-2.4,2.5
ENSMUSG00000021771,VDAC2,voltage-dependent anion channel 2,nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial nucleoid|pore complex|extracellular vesicular exosome|,anion transport|negative regulation of protein polymerization|regulation of anion transport|transmembrane transport|negative regulation of intrinsic apoptotic signaling pathway|,nucleotide binding|protein binding|voltage-gated anion channel activity|porin activity|,10,-0.9,1.03,10,0,0,0,0,0.885,-2.7,1.4
ENSMUSG00000002944,CD36,CD36 molecule (thrombospondin receptor),extracellular space|Golgi apparatus|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|cell surface|cell surface|membrane|endocytic vesicle membrane|platelet alpha granule membrane|membrane raft|phagocytic vesicle|,"negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell-matrix adhesion|toll-like receptor signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|platelet degranulation|MyD88-dependent toll-like receptor signaling pathway|lipid metabolic process|receptor-mediated endocytosis|receptor-mediated endocytosis|receptor-mediated endocytosis|phagocytosis, recognition|cell adhesion|cell surface receptor signaling pathway|nitric oxide mediated signal transduction|blood coagulation|positive regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol storage|plasma membrane long-chain fatty acid transport|lipid storage|cGMP-mediated signaling|platelet activation|positive regulation of blood coagulation|cholesterol transport|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|plasma lipoprotein particle clearance|low-density lipoprotein particle clearance|response to stilbenoid|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|lipoprotein transport|lipoprotein transport|negative regulation of transcription factor import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|apoptotic cell clearance|positive regulation of MAPK cascade|negative regulation of growth of symbiont in host|cellular lipid metabolic process|small molecule metabolic process|long-chain fatty acid import|innate immune response|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-positive bacterium|low-density lipoprotein particle mediated signaling|positive regulation of phagocytosis, engulfment|positive regulation of macrophage cytokine production|cellular response to bacterial lipopeptide|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to hydroperoxide|regulation of removal of superoxide radicals|positive regulation of blood microparticle formation|positive regulation of reactive oxygen species metabolic process|",low-density lipoprotein receptor activity|low-density lipoprotein receptor activity|high-density lipoprotein particle binding|lipid binding|low-density lipoprotein particle binding|transforming growth factor beta binding|thrombospondin receptor activity|lipoteichoic acid receptor activity|lipoprotein particle binding|,10,-0.3,0.0588,10,0,0,0,0,0.885,-6.7,3
ENSMUSG00000039153,RUNX2,runt-related transcription factor 2,nuclear chromatin|nucleus|transcription factor complex|cytoplasm|,"ossification|osteoblast differentiation|osteoblast differentiation|endochondral ossification|osteoblast fate commitment|chondrocyte development|osteoblast development|transcription initiation from RNA polymerase II promoter|positive regulation of cell proliferation|gene expression|T cell differentiation|BMP signaling pathway|positive regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|regulation of fibroblast growth factor receptor signaling pathway|odontogenesis of dentin-containing tooth|regulation of odontogenesis of dentin-containing tooth|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|cell maturation|embryonic cranial skeleton morphogenesis|stem cell differentiation|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|ATP binding|protein domain specific binding|bHLH transcription factor binding|repressing transcription factor binding|,10,0,0,10,0,0,0,0,0.885,-2.3,1.9
ENSMUSG00000020027,SOCS2,suppressor of cytokine signaling 2,cytoplasm|cytosol|,regulation of cell growth|JAK-STAT cascade|aging|regulation of signal transduction|positive regulation of signal transduction|protein ubiquitination|response to estradiol|cellular response to hormone stimulus|negative regulation of apoptotic process|negative regulation of JAK-STAT cascade|growth hormone receptor signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|,SH3/SH2 adaptor activity|growth hormone receptor binding|insulin-like growth factor receptor binding|protein binding|JAK pathway signal transduction adaptor activity|,10,0,0,10,-0.8,0.413,0,0,0.885,-8.3,2.8
ENSMUSG00000039661,DUSP26,dual specificity phosphatase 26 (putative),nucleus|cytoplasm|mitochondrion|Golgi apparatus|extracellular vesicular exosome|,negative regulation of transcription from RNA polymerase II promoter|protein dephosphorylation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of cell adhesion|negative regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine dephosphorylation|,RNA polymerase II activating transcription factor binding|p53 binding|phosphoserine phosphatase activity|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity|,10,0,0,10,0,0,0,0,0.885,-2.7,2.3
ENSMUSG00000049488,TMEM67,transmembrane protein 67,endoplasmic reticulum membrane|centrosome|integral component of membrane|cytoplasmic vesicle membrane|TCTN-B9D complex|ciliary membrane|,negative regulation of centrosome duplication|ER-associated ubiquitin-dependent protein catabolic process|cilium assembly|cilium morphogenesis|,protein binding|filamin binding|unfolded protein binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000071856,MCC,mutated in colorectal cancers,nucleus|cytoplasm|plasma membrane|lamellipodium|,signal transduction|negative regulation of epithelial cell migration|Wnt signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of canonical Wnt signaling pathway|,receptor activity|protein binding|,10,0,0,10,-0.4,0.131,0,0,0.885,-8,4.7
ENSMUSG00000019326,AOC3,"amine oxidase, copper containing 3",cytoplasm|plasma membrane|microvillus|cell surface|integral component of membrane|,cation transport|inflammatory response|cell adhesion|amine metabolic process|response to antibiotic|oxidation-reduction process|,cation channel activity|copper ion binding|calcium ion binding|protein binding|primary amine oxidase activity|protein homodimerization activity|protein heterodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|,10,0,0,10,0.8,0.265,0,0,0.885,-3.2,6.6
ENSMUSG00000039474,WFS1,Wolfram syndrome 1 (wolframin),endoplasmic reticulum|endoplasmic reticulum membrane|integral component of endoplasmic reticulum membrane|dendrite|,kidney development|renal water homeostasis|ER overload response|ER overload response|activation of signaling protein activity involved in unfolded protein response|visual perception|sensory perception of sound|protein maturation by protein folding|ER-associated ubiquitin-dependent protein catabolic process|endoplasmic reticulum unfolded protein response|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|endoplasmic reticulum calcium ion homeostasis|response to endoplasmic reticulum stress|olfactory behavior|glucose homeostasis|negative regulation of programmed cell death|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neuron apoptotic process|cellular protein metabolic process|positive regulation of proteolysis|positive regulation of growth|protein stabilization|neurological system process|positive regulation of protein metabolic process|positive regulation of calcium ion transport|calcium ion homeostasis|polyubiquitinated misfolded protein transport|negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of type B pancreatic cell apoptotic process|,transporter activity|calmodulin binding|ubiquitin protein ligase binding|activating transcription factor binding|calcium-dependent protein binding|ATPase binding|,10,-5.3,1.35,10,0.7,0.563,0,0,0.885,-9.3,5.6
ENSMUSG00000026770,IL2RA,"interleukin 2 receptor, alpha",plasma membrane|external side of plasma membrane|integral component of membrane|,inflammatory response to antigenic stimulus|apoptotic process|activation-induced cell death of T cells|immune response|cell surface receptor signaling pathway|Notch signaling pathway|cell proliferation|interleukin-2-mediated signaling pathway|positive regulation of activated T cell proliferation|negative regulation of T cell proliferation|positive regulation of T cell differentiation|regulation of T cell homeostatic proliferation|negative regulation of defense response to virus|negative regulation of inflammatory response|negative regulation of immune response|,interleukin-2 receptor activity|drug binding|interleukin-2 binding|,10,1.4,0.849,10,0,0,0,0,0.885,-2.9,5.8
ENSMUSG00000050071,BEX1,"brain expressed, X-linked 1",nucleus|transcription factor complex|cytoplasm|,nervous system development|cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|,RNA polymerase II activating transcription factor binding|,1,-0.2,0.0122,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000027656,WISP2,WNT1 inducible signaling pathway protein 2,extracellular space|plasma membrane|extracellular vesicular exosome|,regulation of cell growth|cell adhesion|signal transduction|cell-cell signaling|,insulin-like growth factor binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2
ENSMUSG00000028864,HGF,hepatocyte growth factor (hepapoietin A; scatter factor),extracellular region|extracellular space|membrane|platelet alpha granule lumen|,activation of MAPK activity|epithelial to mesenchymal transition|liver development|platelet degranulation|mitotic nuclear division|blood coagulation|positive regulation of phosphatidylinositol 3-kinase signaling|platelet activation|hyaluronan metabolic process|positive regulation of cell migration|organ regeneration|cellular response to hepatocyte growth factor stimulus|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|hepatocyte growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|myoblast proliferation|cell chemotaxis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling|negative regulation of release of cytochrome c from mitochondria|negative regulation of hydrogen peroxide-mediated programmed cell death|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of DNA biosynthetic process|,protein binding|growth factor activity|chemoattractant activity|identical protein binding|protein heterodimerization activity|,10,-0.4,0.202,10,0.1,0.0243,0,0,0.885,-2.5,2.4
ENSMUSG00000030724,CD19,CD19 molecule,plasma membrane|integral component of plasma membrane|external side of plasma membrane|extracellular vesicular exosome|,cellular defense response|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of immune response|B cell receptor signaling pathway|,receptor signaling protein activity|,10,0.4,0.126,10,0,0,0,0,0.885,-2,3.4
ENSMUSG00000032280,TLE3,transducin-like enhancer of split 3,nucleus|nucleoplasm|,"transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|Notch signaling pathway|organ morphogenesis|Wnt signaling pathway|",protein binding|,10,0,0,10,-0.3,0.0978,0,0,0.885,-3.8,2.6
ENSMUSG00000025215,TLX1,T-cell leukemia homeobox 1,nucleus|,central nervous system development|positive regulation of cell proliferation|neuron differentiation|cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|spleen development|organ formation|,sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|protein heterodimerization activity|,10,0,0,10,0,0,0,0,0.885,-3.5,3
ENSMUSG00000021177,TDP1,tyrosyl-DNA phosphodiesterase 1,nucleus|cytoplasm|,single strand break repair|single strand break repair|DNA repair|double-strand break repair|cell death|nucleic acid phosphodiester bond hydrolysis|,double-stranded DNA binding|single-stranded DNA binding|exonuclease activity|protein binding|3'-tyrosyl-DNA phosphodiesterase activity|,10,0,0,10,0,0,0,0,0.885,-6.3,2.6
ENSMUSG00000033066,GAS7,growth arrest-specific 7,ruffle|cytoplasm|actin filament|,"regulation of transcription, DNA-templated|cell cycle arrest|regulation of cell shape|actin filament polymerization|neuron projection morphogenesis|actin filament bundle assembly|",sequence-specific DNA binding transcription factor activity|actin filament binding|,10,0,0,10,0.9,0.94,0,0,0.885,-1.8,3
ENSMUSG00000024308,TAPBP,TAP binding protein (tapasin),Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|MHC class I peptide loading complex|TAP complex|integral component of lumenal side of endoplasmic reticulum membrane|,"antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER|immune response|peptide transport|antigen processing and presentation of endogenous peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I|amide transport|peptide antigen stabilization|",protein binding|peptide antigen-transporting ATPase activity|MHC class I protein binding|peptide antigen binding|TAP1 binding|TAP1 binding|TAP2 binding|TAP2 binding|unfolded protein binding|,10,0,0,10,0,0,0,0,0.885,-3,2.7
ENSMUSG00000017737,MMP9,"matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)",extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular vesicular exosome|,skeletal system development|ossification|proteolysis|embryo implantation|extracellular matrix disassembly|extracellular matrix organization|macrophage differentiation|collagen catabolic process|positive regulation of apoptotic process|leukocyte migration|positive regulation of keratinocyte migration|positive regulation of receptor binding|negative regulation of cation channel activity|,metalloendopeptidase activity|protein binding|collagen binding|zinc ion binding|identical protein binding|,10,0,0,10,-0.4,0.0796,0,0,0.885,-4,4.8
ENSMUSG00000030865,CHP2,calcineurin-like EF-hand protein 2,nucleus|cytoplasm|plasma membrane|,positive regulation of cell proliferation|positive regulation of phosphatase activity|protein transport|positive regulation of protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of calcineurin-NFAT signaling cascade|cellular response to calcium ion|,calcium ion binding|protein binding|,8,-0.6,0.171,9,0,0,0,0,0.885,-5.3,2
ENSMUSG00000034341,WBP2,WW domain binding protein 2,nuclear chromatin|,"establishment of protein localization|positive regulation of gene expression, epigenetic|positive regulation of transcription from RNA polymerase II promoter|cellular response to estrogen stimulus|positive regulation of histone H3-K14 acetylation|",RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription coactivator activity|protein binding|chromatin DNA binding|,10,0,0,10,-0.5,0.268,0,0,0.885,-5.9,2.7
ENSMUSG00000049119,FAM110B,"family with sequence similarity 110, member B",cytoplasm|microtubule organizing center|,None,None,10,0.2,0.055,10,0,0,0,0,0.885,-2.8,2.8
ENSMUSG00000006344,GGT5,gamma-glutamyltransferase 5,plasma membrane|integral component of membrane|anchored component of external side of plasma membrane|,proteolysis|cellular amino acid metabolic process|leukotriene metabolic process|glutathione metabolic process|glutathione biosynthetic process|inflammatory response|arachidonic acid metabolic process|leukotriene biosynthetic process|small molecule metabolic process|,gamma-glutamyltransferase activity|glutathione hydrolase activity|,10,-2,0.168,10,0,0,0,0,0.885,-7.2,4.6
ENSMUSG00000038668,LPAR1,lysophosphatidic acid receptor 1,plasma membrane|integral component of plasma membrane|cell surface|endocytic vesicle|dendritic spine|dendritic shaft|,activation of MAPK activity|G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|negative regulation of neuron projection development|bleb assembly|positive regulation of Rho protein signal transduction|myelination|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of dendritic spine development|cellular response to oxygen levels|positive regulation of smooth muscle cell chemotaxis|,G-protein alpha-subunit binding|G-protein coupled receptor activity|protein binding|phospholipid binding|PDZ domain binding|lysophosphatidic acid receptor activity|,10,0,0,10,0,0,0,0,0.885,-4,3.9
ENSMUSG00000022443,MYH9,"myosin, heavy chain 9, non-muscle",stress fiber|ruffle|immunological synapse|uropod|nucleus|cytoplasm|spindle|actomyosin contractile ring|cytosol|plasma membrane|plasma membrane|cell-cell adherens junction|COP9 signalosome|integrin complex|actin cytoskeleton|membrane|myosin II complex|cortical cytoskeleton|cell leading edge|neuromuscular junction|cleavage furrow|actomyosin|protein complex|extracellular vesicular exosome|myosin II filament|,meiotic spindle organization|cytokinesis|angiogenesis|in utero embryonic development|establishment of T cell polarity|ATP catabolic process|membrane protein ectodomain proteolysis|integrin-mediated signaling pathway|axon guidance|myoblast fusion|regulation of cell shape|protein transport|single organismal cell-cell adhesion|actin filament-based movement|platelet formation|monocyte differentiation|actomyosin structure organization|actin cytoskeleton reorganization|uropod organization|termination of G-protein coupled receptor signaling pathway|blood vessel endothelial cell migration|leukocyte migration|establishment of meiotic spindle localization|,microfilament motor activity|motor activity|actin binding|protein binding|calmodulin binding|ATP binding|ATPase activity|actin-dependent ATPase activity|actin-dependent ATPase activity|protein homodimerization activity|protein anchor|ADP binding|poly(A) RNA binding|actin filament binding|actin filament binding|actin filament binding|,10,-0.8,0.473,10,0.1,0.00406,0,0,0.885,-5.6,3
ENSMUSG00000022085,PEBP4,phosphatidylethanolamine-binding protein 4,lysosome|,None,protein binding|,9,0.8,0.169,9,0,0,0,0,0.885,-3.4,3.1
ENSMUSG00000043099,HIC1,hypermethylated in cancer 1,chromatin|nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|intrinsic apoptotic signaling pathway in response to DNA damage|Wnt signaling pathway|negative regulation of Wnt signaling pathway|positive regulation of DNA damage response, signal transduction by p53 class mediator|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|protein binding|histone deacetylase binding|sequence-specific DNA binding|metal ion binding|,10,0,0,10,-0.1,0.0176,0,0,0.885,-3.6,2.9
ENSMUSG00000070637,GM694,predicted gene 694,cellular_component|,biological_process|,molecular_function|,10,-0.5,0.137,10,0,0,0,0,0.885,-3.5,2
ENSMUSG00000031790,MMP15,matrix metallopeptidase 15 (membrane-inserted),plasma membrane|integral component of plasma membrane|extracellular matrix|,cellular protein modification process|proteolysis|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|response to estradiol|positive regulation of catalytic activity|,metalloendopeptidase activity|calcium ion binding|protein binding|enzyme activator activity|zinc ion binding|,10,0,0,10,0,0,0,0,0.885,-2.4,2.5
ENSMUSG00000011382,DHDH,dihydrodiol dehydrogenase (dimeric),None,carbohydrate metabolic process|D-xylose catabolic process|oxidation-reduction process|,"NAD(P)+ transhydrogenase activity|electron carrier activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|D-xylose 1-dehydrogenase (NADP+) activity|",10,0,0,10,0.5,0.202,0,0,0.885,-7.1,4
ENSMUSG00000029378,AREG,amphiregulin,extracellular space|cell surface|integral component of membrane|,epidermal growth factor receptor signaling pathway|G-protein coupled receptor signaling pathway|cell-cell signaling|cell proliferation|positive regulation of DNA replication|,cytokine activity|protein binding|growth factor activity|,10,-0.2,0.0937,10,0,0,0,0,0.885,-8.2,2.7
ENSMUSG00000020801,MED31,mediator complex subunit 31,nucleoplasm|mediator complex|,regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|protein complex assembly|gene expression|negative regulation of fibroblast proliferation|limb development|,RNA polymerase II transcription cofactor activity|protein binding|protein complex binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000044542,PROP1,PROP paired-like homeobox 1,nucleus|transcription factor complex|,negative regulation of transcription from RNA polymerase II promoter|blood vessel development|central nervous system development|dorsal/ventral pattern formation|cell migration|hypothalamus cell differentiation|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|hypophysis morphogenesis|canonical Wnt signaling pathway|somatotropin secreting cell differentiation|,transcription regulatory region sequence-specific DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|beta-catenin binding|protein C-terminus binding|,10,-0.1,0.00903,10,0,0,0,0,0.885,-4.7,3
ENSMUSG00000018169,MFNG,MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase,extracellular space|integral component of Golgi membrane|,pattern specification process|metabolic process|positive regulation of protein binding|positive regulation of Notch signaling pathway|,O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|metal ion binding|,10,-0.7,0.226,10,0,0,0,0,0.885,-3,2.4
ENSMUSG00000028017,EGF,epidermal growth factor,extracellular region|extracellular region|extracellular space|lysosomal membrane|plasma membrane|integral component of membrane|platelet alpha granule lumen|extracellular vesicular exosome|,"activation of MAPKK activity|angiogenesis|platelet degranulation|DNA replication|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|epidermal growth factor receptor signaling pathway|STAT protein import into nucleus|blood coagulation|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|positive regulation of cerebellar granule cell precursor proliferation|platelet activation|positive regulation of catenin import into nucleus|Fc-epsilon receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphorylation|positive regulation of DNA binding|positive regulation of MAP kinase activity|innate immune response|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitosis|positive regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|branching morphogenesis of an epithelial tube|negative regulation of secretion|mammary gland alveolus development|ERK1 and ERK2 cascade|regulation of calcium ion import|negative regulation of cholesterol efflux|positive regulation of hyaluronan biosynthetic process|regulation of protein localization to cell surface|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|",epidermal growth factor receptor binding|calcium ion binding|protein binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity|,10,0.2,0.0831,10,-0.8,0.466,0,0,0.885,-6.1,3.2
ENSMUSG00000021009,PTPN21,"protein tyrosine phosphatase, non-receptor type 21",cytoplasm|cytoskeleton|,protein dephosphorylation|peptidyl-tyrosine dephosphorylation|peptidyl-tyrosine dephosphorylation|,protein tyrosine phosphatase activity|protein binding|,10,0,0,10,-0.2,0.0338,0,0,0.885,-8.3,6
ENSMUSG00000034613,PPM1H,"protein phosphatase, Mg2+/Mn2+ dependent, 1H",None,dephosphorylation|,phosphoprotein phosphatase activity|,10,-0.1,0.0122,10,0.5,0.29,0,0,0.885,-3.6,4.4
ENSMUSG00000031077,FADD,Fas (TNFRSF6)-associated via death domain,cytosol|cytosol|death-inducing signaling complex|death-inducing signaling complex|CD95 death-inducing signaling complex|neuron projection|cell body|membrane raft|ripoptosome|,"positive regulation of T cell mediated cytotoxicity|toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of adaptive immune response|apoptotic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|viral process|positive regulation of interferon-gamma production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|T cell differentiation in thymus|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|TRAIL-activated apoptotic signaling pathway|positive regulation of activated T cell proliferation|T cell homeostasis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of macrophage differentiation|positive regulation of proteolysis|positive regulation of transcription from RNA polymerase II promoter|lymph node development|spleen development|thymus development|protein heterooligomerization|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|negative regulation of activation-induced cell death of T cells|cellular response to mechanical stimulus|motor neuron apoptotic process|apoptotic signaling pathway|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|activation of cysteine-type endopeptidase activity|necroptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|positive regulation of extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|",protease binding|death receptor binding|tumor necrosis factor receptor binding|protein binding|tumor necrosis factor receptor superfamily binding|death effector domain binding|identical protein binding|,10,0,0,10,0,0,0,0,0.885,-2.7,2.3
ENSMUSG00000036073,GALT,galactose-1-phosphate uridylyltransferase,Golgi apparatus|cytosol|,carbohydrate metabolic process|galactose metabolic process|UDP-glucose catabolic process|galactose catabolic process|small molecule metabolic process|,UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding|,10,0,0,10,0,0,0,0,0.885,-2,2.7
ENSMUSG00000024304,CDH2,"cadherin 2, type 1, N-cadherin (neuronal)",plasma membrane|cell-cell junction|cell-cell adherens junction|fascia adherens|intercalated disc|integral component of membrane|apical plasma membrane|catenin complex|lamellipodium|synapse|extracellular vesicular exosome|,cell adhesion|homophilic cell adhesion|heterophilic cell-cell adhesion|calcium-dependent cell-cell adhesion|cell migration|cell junction assembly|adherens junction organization|muscle cell differentiation|positive regulation of MAPK cascade|cell-cell junction organization|blood vessel morphogenesis|striated muscle cell differentiation|positive regulation of muscle cell differentiation|negative regulation of canonical Wnt signaling pathway|,calcium ion binding|protein binding|beta-catenin binding|protein phosphatase binding|alpha-catenin binding|gamma-catenin binding|,10,-0.4,0.114,10,0,0,0,0,0.885,-2.7,2.2
ENSMUSG00000028252,CCNC,cyclin C,"nucleoplasm|DNA-directed RNA polymerase II, holoenzyme|mediator complex|","regulation of cyclin-dependent protein serine/threonine kinase activity|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|gene expression|positive regulation of transcription from RNA polymerase II promoter|",protein binding|protein kinase binding|,10,0,0,10,0,0,0,0,0.885,-2.8,2.9
ENSMUSG00000031592,PCM1,pericentriolar material 1,pericentriolar material|cytoplasm|cytoplasm|centrosome|centrosome|cytosol|membrane|nuclear membrane|centriolar satellite|protein complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|interkinetic nuclear migration|cytoplasmic microtubule organization|microtubule anchoring|microtubule anchoring at centrosome|intraciliary transport involved in cilium morphogenesis|cilium assembly|negative regulation of neurogenesis|centrosome organization|protein localization to centrosome|positive regulation of intracellular protein transport|neuronal stem cell maintenance|,protein binding|identical protein binding|,10,0,0,10,0.4,0.154,0,0,0.885,-3.5,3.6
ENSMUSG00000032766,GNG11,"guanine nucleotide binding protein (G protein), gamma 11",heterotrimeric G-protein complex|plasma membrane|,energy reserve metabolic process|GTP catabolic process|signal transduction|G-protein coupled receptor signaling pathway|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|,9,0,0,9,0,0,0,0,0.885,-1.9,1.6
ENSMUSG00000037808,FAM76B,"family with sequence similarity 76, member B",nucleus|nuclear speck|nuclear membrane|,None,None,10,0,0,9,1.1,0.488,0,0,0.885,-4.6,8
ENSMUSG00000074743,THBD,thrombomodulin,extracellular space|plasma membrane|integral component of plasma membrane|cell surface|,signal transduction|female pregnancy|blood coagulation|embryo development|response to X-ray|negative regulation of platelet activation|negative regulation of blood coagulation|response to lipopolysaccharide|leukocyte migration|response to cAMP|negative regulation of fibrinolysis|,receptor activity|transmembrane signaling receptor activity|calcium ion binding|protein binding|carbohydrate binding|,10,0,0,10,-0.2,0.0833,0,0,0.885,-3.4,2
ENSMUSG00000024403,ATP6V1G2,"ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2",cytosol|vacuolar proton-transporting V-type ATPase complex|integral component of synaptic vesicle membrane|melanosome|,ATP catabolic process|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|hydrogen ion transmembrane transport|,"hydrogen-exporting ATPase activity, phosphorylative mechanism|",10,0,0,10,0,0,0,0,0.885,-4.3,3.7
ENSMUSG00000026072,IL1R1,"interleukin 1 receptor, type I",extracellular region|plasma membrane|integral component of plasma membrane|cell surface|membrane|,immune response|cell surface receptor signaling pathway|regulation of inflammatory response|interleukin-1-mediated signaling pathway|response to interleukin-1|,"protease binding|signal transducer activity|transmembrane signaling receptor activity|interleukin-1 receptor activity|interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding|protein binding|",10,-0.2,0.0214,10,0,0,0,0,0.885,-4.3,2
ENSMUSG00000020463,SMEK2,"SMEK homolog 2, suppressor of mek1 (Dictyostelium)",nucleus|cytoplasm|microtubule organizing center|protein phosphatase 4 complex|,protein dephosphorylation|regulation of lipid metabolic process|positive regulation of gluconeogenesis|,None,10,0,0,10,0,0,0,0,0.885,-7.3,3
ENSMUSG00000010057,NPRL2,nitrogen permease regulator-like 2 (S. cerevisiae),None,protein phosphorylation|negative regulation of kinase activity|positive regulation of GTPase activity|,protein kinase activity|GTPase activator activity|protein binding|,10,0,0,10,0,0,0,0,0.885,-2,6.2
ENSMUSG00000090626,TEX9,testis expressed 9,None,None,None,10,-1.6,0.477,10,0,0,0,0,0.885,-3.9,1.8
ENSMUSG00000029671,WNT16,"wingless-type MMTV integration site family, member 16",extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|,optic cup formation involved in camera-type eye development|positive regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt signaling pathway|neuron differentiation|keratinocyte differentiation|keratinocyte proliferation|cell fate commitment|positive regulation of JNK cascade|cardiac epithelial to mesenchymal transition|negative regulation of cell death|replicative senescence|oxidative stress-induced premature senescence|,frizzled binding|,10,-0.1,0.000809,10,0,0,0,0,0.885,-3.3,2.4
ENSMUSG00000031974,ABCB10,"ATP-binding cassette, sub-family B (MDR/TAP), member 10",mitochondrial inner membrane|integral component of mitochondrial membrane|,ATP catabolic process|transport|transmembrane transport|,"transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of substances|protein homodimerization activity|",10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000074916,CHST14,carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14,Golgi membrane|integral component of membrane|extracellular vesicular exosome|,carbohydrate metabolic process|carbohydrate biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|dermatan sulfate biosynthetic process|small molecule metabolic process|dermatan sulfate proteoglycan metabolic process|,N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate ion binding|,10,0,0,10,0.1,0.0183,0,0,0.885,-4.8,2.5
ENSMUSG00000008822,ACYP1,"acylphosphatase 1, erythrocyte (common) type",extracellular vesicular exosome|,phosphate-containing compound metabolic process|,acylphosphatase activity|,10,0,0,10,-0.3,0.0869,0,0,0.885,-8.7,2.4
ENSMUSG00000048755,MCAT,malonyl CoA:ACP acyltransferase (mitochondrial),mitochondrion|,fatty acid biosynthetic process|fatty acid biosynthetic process|metabolic process|,[acyl-carrier-protein] S-malonyltransferase activity|transferase activity|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-3.2,2.5
ENSMUSG00000056952,TATDN2,TatD DNase domain containing 2,nucleoplasm|intracellular organelle|,"DNA catabolic process, endonucleolytic|DNA catabolic process|activation of signaling protein activity involved in unfolded protein response|endoplasmic reticulum unfolded protein response|cellular protein metabolic process|","deoxyribonuclease activity|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|",0,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000004038,GSTM3,glutathione S-transferase mu 3 (brain),nucleus|cytoplasm|cytosol|extracellular vesicular exosome|,glutathione metabolic process|xenobiotic metabolic process|establishment of blood-nerve barrier|nitrobenzene metabolic process|xenobiotic catabolic process|response to estrogen|small molecule metabolic process|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process|,glutathione transferase activity|enzyme binding|identical protein binding|protein homodimerization activity|protein homodimerization activity|glutathione binding|,1,0.4,0.0539,1,0,0,0,0,0.885,-1.8,2
ENSMUSG00000027643,GHRH,growth hormone releasing hormone,extracellular region|extracellular region|extracellular space|terminal bouton|,"adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|cell-cell signaling|positive regulation of cell proliferation|cAMP-mediated signaling|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|response to food|positive regulation of multicellular organism growth|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of growth hormone secretion|positive regulation of growth hormone secretion|",growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding|,7,-1,0.396,10,0.2,0.0383,0,0,0.885,-2.7,1.6
ENSMUSG00000037032,APBB1,"amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)",nucleus|nucleus|cytoplasm|plasma membrane|nuclear speck|lamellipodium|growth cone|synapse|,"neuron migration|double-strand break repair|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|signal transduction|axonogenesis|axon guidance|visual learning|extracellular matrix organization|negative regulation of cell growth|positive regulation of apoptotic process|histone H4 acetylation|negative regulation of neuron differentiation|positive regulation of DNA repair|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of thymidylate synthase biosynthetic process|",beta-amyloid binding|beta-amyloid binding|chromatin binding|protein binding|transcription factor binding|histone binding|proline-rich region binding|,10,0,0,10,0,0,0,0,0.885,-1.6,1.8
ENSMUSG00000042622,MAFF,v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F,nucleoplasm|,"in utero embryonic development|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|parturition|blood coagulation|skeletal muscle cell differentiation|regulation of epidermal cell differentiation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0,0,10,0.4,0.134,0,0,0.885,-1.8,2.4
ENSMUSG00000020135,APC2,adenomatosis polyposis coli 2,Golgi membrane|cytoplasm|Golgi apparatus|cytoplasmic microtubule|actin filament|microtubule cytoskeleton|catenin complex|lamellipodium membrane|perinuclear region of cytoplasm|,Wnt signaling pathway|negative regulation of catenin import into nucleus|negative regulation of canonical Wnt signaling pathway|,protein binding|beta-catenin binding|microtubule binding|,10,-2.5,1.21,10,0.7,0.15,0,0,0.885,-7.5,2.9
ENSMUSG00000079334,NAT6,N-acetyltransferase 6 (GCN5-related),cytoplasm|,metabolic process|,N-acetyltransferase activity|,9,0,0,9,-0.3,0.0141,0,0,0.885,-3.1,1.9
ENSMUSG00000025278,FLNB,"filamin B, beta",stress fiber|cytoplasm|cytosol|plasma membrane|focal adhesion|cell cortex|actin cytoskeleton|integral component of membrane|Z disc|extracellular vesicular exosome|,cytoskeletal anchoring at plasma membrane|signal transduction|skeletal muscle tissue development|cytokine-mediated signaling pathway|actin cytoskeleton organization|cell differentiation|,actin binding|protein binding|identical protein binding|poly(A) RNA binding|,10,0,0,10,0.3,0.0427,0,0,0.885,-5.9,3
ENSMUSG00000026043,COL3A1,"collagen, type III, alpha 1",extracellular region|collagen type III trimer|collagen type III trimer|extracellular space|extracellular space|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|,skeletal system development|blood vessel development|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|heart development|aging|response to radiation|response to mechanical stimulus|peptide cross-linking|cerebral cortex development|extracellular matrix disassembly|platelet activation|extracellular matrix organization|collagen fibril organization|collagen fibril organization|collagen catabolic process|response to cytokine|positive regulation of Rho protein signal transduction|wound healing|wound healing|extracellular fibril organization|skin development|digestive tract development|negative regulation of immune response|cellular response to amino acid stimulus|negative regulation of neuron migration|,integrin binding|integrin binding|extracellular matrix structural constituent|protein binding|SMAD binding|metal ion binding|platelet-derived growth factor binding|,10,0.9,0.253,10,0,0,0,0,0.885,-7,5
ENSMUSG00000053475,TNFAIP6,"tumor necrosis factor, alpha-induced protein 6",None,inflammatory response|cell adhesion|signal transduction|cell-cell signaling|,hyaluronic acid binding|,10,-0.4,0.195,10,0,0,0,0,0.885,-8.4,7
ENSMUSG00000040548,TEX2,testis expressed 2,integral component of membrane|,sphingolipid metabolic process|signal transduction|,molecular_function|,10,0,0,10,0,0,0,0,0.885,-3.6,2
ENSMUSG00000031383,DUSP9,dual specificity phosphatase 9,nucleus|cytoplasm|,inactivation of MAPK activity|protein dephosphorylation|JNK cascade|peptidyl-tyrosine dephosphorylation|,phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|,10,0.1,0.00668,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000022387,BRD1,bromodomain containing 1,nucleus|nucleus|MOZ/MORF histone acetyltransferase complex|,histone H3 acetylation|,zinc ion binding|histone binding|,10,0.1,0.00318,10,-0.3,0.156,0,0,0.885,-3.5,2.9
ENSMUSG00000031551,IDO1,"indoleamine 2,3-dioxygenase 1",cytosol|smooth muscle contractile fiber|stereocilium bundle|,cytokine production involved in inflammatory response|positive regulation of T cell tolerance induction|positive regulation of chronic inflammatory response|positive regulation of type 2 immune response|tryptophan catabolic process|female pregnancy|tryptophan catabolic process to kynurenine|response to lipopolysaccharide|negative regulation of interleukin-10 production|positive regulation of interleukin-12 production|multicellular organismal response to stress|kynurenic acid biosynthetic process|cellular nitrogen compound metabolic process|swimming behavior|positive regulation of apoptotic process|small molecule metabolic process|negative regulation of activated T cell proliferation|oxidation-reduction process|negative regulation of T cell apoptotic process|,"tryptophan 2,3-dioxygenase activity|electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|metal ion binding|",10,0.2,0.00629,10,-0.3,0.125,0,0,0.885,-2.9,2.7
ENSMUSG00000048910,FAM220A,"family with sequence similarity 220, member A",nucleus|,None,None,10,0.2,0.0127,10,-0.1,0.000558,0,0,0.885,-5.5,3.9
ENSMUSG00000062270,MORF4L1,mortality factor 4 like 1,nucleoplasm|Sin3 complex|NuA4 histone acetyltransferase complex|,"double-strand break repair via homologous recombination|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|cell proliferation|histone deacetylation|regulation of growth|histone H4 acetylation|histone H2A acetylation|",chromatin binding|protein binding|protein N-terminus binding|,10,-2.3,0.206,10,-1.2,0.0332,0,0,0.885,-6.1,1.8
ENSMUSG00000062074,WISP3,WNT1 inducible signaling pathway protein 3,extracellular space|,regulation of cell growth|signal transduction|cell-cell signaling|,insulin-like growth factor binding|growth factor activity|,10,-0.9,0.595,10,0,0,0,0,0.885,-5.4,2.7
ENSMUSG00000048776,PTHLH,parathyroid hormone-like hormone,extracellular region|extracellular space|nucleus|cytoplasm|Golgi apparatus|,skeletal system development|endochondral ossification|osteoblast development|adenylate cyclase-activating G-protein coupled receptor signaling pathway|cell-cell signaling|endoderm development|female pregnancy|positive regulation of cell proliferation|negative regulation of cell proliferation|epidermis development|regulation of gene expression|protein processing|positive regulation of cAMP biosynthetic process|epithelial cell differentiation|negative regulation of chondrocyte differentiation|surfactant homeostasis|negative regulation of sequence-specific DNA binding transcription factor activity|cAMP metabolic process|lung alveolus development|mammary gland bud elongation|nipple sheath formation|,hormone activity|peptide hormone receptor binding|,10,-0.9,0.5,10,0,0,0,0,0.885,-3.8,2.4
ENSMUSG00000020893,PER1,period circadian clock 1,nucleus|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|regulation of sodium ion transport|transcription, DNA-templated|signal transduction|circadian rhythm|entrainment of circadian clock|posttranscriptional regulation of gene expression|circadian regulation of gene expression|regulation of hair cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|entrainment of circadian clock by photoperiod|histone H3 acetylation|histone H4 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of JNK cascade|histone H3 deacetylation|circadian regulation of translation|regulation of cytokine production involved in inflammatory response|regulation of p38MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|transcription factor binding transcription factor activity|signal transducer activity|kinase binding|chromatin DNA binding|ubiquitin protein ligase binding|E-box binding|,10,0.1,0.00549,10,0,0,0,0,0.885,-2.7,2.9
ENSMUSG00000054892,TXK,TXK tyrosine kinase,nucleus|cytoplasm|plasma membrane|,"cytokine production|NK T cell differentiation|adaptive immune response|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|activation of phospholipase C activity|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation|interferon-gamma production|interleukin-4 production|positive regulation of interferon-gamma production|protein autophosphorylation|T cell receptor signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|",RNA polymerase II regulatory region DNA binding|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|,10,-1.1,0.285,10,0,0,0,0,0.885,-7.3,3
ENSMUSG00000038268,OVCA2,ovarian tumor suppressor candidate 2,nucleus|cytoplasm|,metabolic process|response to retinoic acid|,hydrolase activity|,9,0,0,9,-0.2,0.031,0,0,0.885,-2.4,1.8
ENSMUSG00000029621,ARPC1A,"actin related protein 2/3 complex, subunit 1A, 41kDa",cytosol|actin cytoskeleton|extracellular vesicular exosome|,actin cytoskeleton organization|regulation of actin filament polymerization|Fc-gamma receptor signaling pathway involved in phagocytosis|innate immune response|,actin binding|,10,0,0,10,0.5,0.135,0,0,0.885,-6.5,6.9
ENSMUSG00000005836,GATA6,GATA binding protein 6,nucleus|nucleoplasm|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|liver development|outflow tract septum morphogenesis|type B pancreatic cell differentiation|pancreatic A cell differentiation|transcription from RNA polymerase II promoter|phospholipid metabolic process|endodermal cell fate determination|blood coagulation|male gonad development|cardiac muscle hypertrophy in response to stress|negative regulation of transforming growth factor beta1 production|negative regulation of transforming growth factor beta2 production|tube morphogenesis|response to drug|negative regulation of apoptotic process|response to estrogen|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|organ formation|smooth muscle cell differentiation|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|positive regulation of cardiac muscle cell proliferation|lung saccule development|Clara cell differentiation|Type II pneumocyte differentiation|intestinal epithelial cell differentiation|cardiac vascular smooth muscle cell differentiation|response to growth factor|positive regulation of cell cycle arrest|cellular response to gonadotropin stimulus|cellular response to hypoxia|cellular response to BMP stimulus|",RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II repressing transcription factor binding|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|zinc ion binding|protein kinase binding|transcription regulatory region DNA binding|,10,-0.3,0.0632,10,0.1,0.0177,0,0,0.885,-2.7,2.9
ENSMUSG00000071646,MTA2,"metastasis associated 1 family, member 2",histone deacetylase complex|nuclear chromatin|nucleus|transcription factor complex|membrane|NuRD complex|protein complex|,negative regulation of transcription from RNA polymerase II promoter|DNA methylation|chromatin assembly or disassembly|histone deacetylation|ATP-dependent chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcription factor binding transcription factor activity|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|histone deacetylase activity|protein binding|zinc ion binding|nucleosomal DNA binding|,10,0,0,10,0,0,0,0,0.885,-9,4
ENSMUSG00000066687,ZBTB16,zinc finger and BTB domain containing 16,nucleus|cytosol|plasma membrane|nuclear body|PML body|nuclear speck|transcriptional repressor complex|,"mesonephros development|transcription, DNA-templated|apoptotic process|central nervous system development|negative regulation of cell proliferation|embryonic pattern specification|anterior/posterior pattern specification|protein ubiquitination|hemopoiesis|hemopoiesis|myeloid cell differentiation|positive regulation of chondrocyte differentiation|protein localization to nucleus|embryonic hindlimb morphogenesis|forelimb morphogenesis|embryonic digit morphogenesis|positive regulation of apoptotic process|positive regulation of fat cell differentiation|negative regulation of myeloid cell differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|male germ-line stem cell asymmetric division|cartilage development|positive regulation of cartilage development|",DNA binding|DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|protein C-terminus binding|protein domain specific binding|identical protein binding|protein homodimerization activity|metal ion binding|,10,0.2,0.0789,10,0,0,0,0,0.885,-2,2.9
ENSMUSG00000028456,UNC13B,unc-13 homolog B (C. elegans),cytoplasm|Golgi apparatus|cytosol|plasma membrane|cell junction|neuromuscular junction|,"apoptotic process|signal transduction|neuromuscular junction development|excretion|synaptic vesicle docking involved in exocytosis|synaptic vesicle priming|synaptic transmission, glutamatergic|intracellular signal transduction|regulation of short-term neuronal synaptic plasticity|innervation|",signal transducer activity|receptor activity|protein binding|diacylglycerol binding|metal ion binding|,10,0,0,10,-0.1,0.00282,0,0,0.885,-3.2,2.5
ENSMUSG00000025907,RB1CC1,RB1-inducible coiled-coil 1,cytoplasm|cytosol|nuclear membrane|pre-autophagosomal structure membrane|ULK1-ATG13-FIP200 complex|,"autophagic vacuole assembly|liver development|positive regulation of protein phosphorylation|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|JNK cascade|heart development|regulation of autophagy|negative regulation of apoptotic process|positive regulation of cell size|negative regulation of extrinsic apoptotic signaling pathway|",protein binding|protein kinase binding|,10,0,0,10,1,0.518,0,0,0.885,-3.9,4
ENSMUSG00000068327,TLX2,T-cell leukemia homeobox 2,cellular_component|nucleus|cytoplasm|,"mesoderm formation|transcription, DNA-templated|regulation of transcription, DNA-templated|biological_process|enteric nervous system development|negative regulation of dendrite morphogenesis|",molecular_function|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,-0.2,0.0815,9,0.1,0.0158,0,0,0.885,-10.3,2
ENSMUSG00000009621,VAV2,vav 2 guanine nucleotide exchange factor,cytosol|plasma membrane|,angiogenesis|signal transduction|small GTPase mediated signal transduction|axon guidance|blood coagulation|regulation of gene expression|cell migration|lamellipodium assembly|platelet activation|regulation of blood coagulation|positive regulation of Rho GTPase activity|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of GTPase activity|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|neurotrophin TRK receptor signaling pathway|regulation of small GTPase mediated signal transduction|apoptotic signaling pathway|,guanyl-nucleotide exchange factor activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|protein binding|metal ion binding|,10,0,0,10,1.2,0.688,0,0,0.885,-6.2,5
ENSMUSG00000022449,ADAMTS20,"ADAM metallopeptidase with thrombospondin type 1 motif, 20",proteinaceous extracellular matrix|extracellular space|extracellular matrix|,proteolysis|positive regulation of signal transduction|extracellular matrix organization|negative regulation of apoptotic process|positive regulation of melanocyte differentiation|,metalloendopeptidase activity|zinc ion binding|,10,0,0,10,0,0,0,0,0.885,-3.8,7.2
ENSMUSG00000032059,ALG9,"ALG9, alpha-1,2-mannosyltransferase",endoplasmic reticulum membrane|membrane|integral component of membrane|,dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|mannosylation|,"dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|",0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000058239,USF2,"upstream transcription factor 2, c-fos interacting",nucleus|,"regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|transcription, DNA-templated|transcription from RNA polymerase II promoter|lactation|late viral transcription|positive regulation of transcription from RNA polymerase II promoter|lipid homeostasis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|protein homodimerization activity|bHLH transcription factor binding|sequence-specific DNA binding|protein heterodimerization activity|,10,-4.2,1.12,10,0.1,0.000305,0,0,0.885,-7.9,4.9
ENSMUSG00000074622,MAFB,v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B,nucleus|transcription factor complex|,"transcription, DNA-templated|segment specification|sensory organ development|respiratory gaseous exchange|rhombomere 5 development|rhombomere 6 development|T cell differentiation in thymus|brain segmentation|inner ear morphogenesis|negative regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|thymus development|",sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|sequence-specific DNA binding|,10,0,0,10,0.3,0.0785,0,0,0.885,-1.9,2.2
ENSMUSG00000069171,NR2F1,"nuclear receptor subfamily 2, group F, member 1",nucleus|nucleoplasm|,negative regulation of transcription from RNA polymerase II promoter|neuron migration|transcription initiation from RNA polymerase II promoter|signal transduction|gene expression|negative regulation of neuron projection development|cerebral cortex regionalization|intracellular receptor signaling pathway|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription from RNA polymerase II promoter|,sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|sequence-specific DNA binding|retinoic acid-responsive element binding|,10,0,0,10,0,0,0,0,0.885,-8.1,3
ENSMUSG00000054136,ADM2,adrenomedullin 2,extracellular region|,angiogenesis|protein phosphorylation|adenylate cyclase-activating G-protein coupled receptor signaling pathway|digestion|feeding behavior|positive regulation of gene expression|positive regulation of angiogenesis|negative regulation of blood pressure|,hormone activity|protein complex binding|,10,-0.5,0.112,10,0,0,0,0,0.885,-3.8,2.6
ENSMUSG00000028684,UROD,uroporphyrinogen decarboxylase,cytosol|,porphyrin-containing compound metabolic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|heme biosynthetic process|small molecule metabolic process|,uroporphyrinogen decarboxylase activity|uroporphyrinogen decarboxylase activity|,10,-0.4,0.201,10,0,0,0,0,0.885,-1.9,1.5
ENSMUSG00000038968,KLK1B16,kallikrein 1-related peptidase b16,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,-3.2,1.27,10,0.3,0.206,0,0,0.885,-9.4,3.3
ENSMUSG00000015647,LAMA5,"laminin, alpha 5",extracellular region|basement membrane|basal lamina|laminin-1 complex|laminin-5 complex|extracellular space|nucleus|extracellular matrix|laminin-10 complex|laminin-10 complex|laminin-11 complex|extracellular vesicular exosome|,angiogenesis|branching involved in ureteric bud morphogenesis|morphogenesis of a polarized epithelium|neural crest cell migration|hair follicle development|cytoskeleton organization|integrin-mediated signaling pathway|muscle organ development|cell recognition|cell proliferation|embryo development|morphogenesis of embryonic epithelium|cell migration|extracellular matrix disassembly|cell differentiation|regulation of cell adhesion|extracellular matrix organization|lung development|regulation of cell migration|substrate adhesion-dependent cell spreading|regulation of cell proliferation|cilium assembly|odontogenesis of dentin-containing tooth|endothelial cell differentiation|regulation of embryonic development|focal adhesion assembly|branching involved in salivary gland morphogenesis|establishment of protein localization to plasma membrane|,integrin binding|structural molecule activity|,10,0,0,10,0,0,0,0,0.885,-7.2,3
ENSMUSG00000078611,GM5901,predicted gene 5901,cellular_component|,biological_process|,molecular_function|,0,0,0,1,0,0,0,0,0.885,-1.8,2
ENSMUSG00000079111,KDELR2,KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2,endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cis-Golgi network|integral component of membrane|extracellular vesicular exosome|,protein retention in ER lumen|intracellular protein transport|vesicle-mediated transport|,KDEL sequence binding|,10,0.2,0.0108,10,0,0,0,0,0.885,-7.5,3
ENSMUSG00000013622,ATRAID,all-trans retinoic acid-induced differentiation factor,nuclear envelope|plasma membrane|integral component of membrane|perinuclear region of cytoplasm|,regulation of gene expression|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|negative regulation of cyclin catabolic process|,molecular_function|protein binding|,10,0,0,10,0.1,0.00311,0,0,0.885,-3.3,3.9
ENSMUSG00000029725,PPP1R35,"protein phosphatase 1, regulatory subunit 35",None,negative regulation of phosphatase activity|,protein phosphatase inhibitor activity|phosphatase binding|,10,0.1,0.0379,10,0,0,0,0,0.885,-1.9,2.3
ENSMUSG00000020826,NOS2,"nitric oxide synthase 2, inducible",intracellular|nucleus|cytoplasm|peroxisome|cytosol|cytosol|cortical cytoskeleton|perinuclear region of cytoplasm|,response to hypoxia|positive regulation of leukocyte mediated cytotoxicity|innate immune response in mucosa|arginine catabolic process|superoxide metabolic process|nitric oxide biosynthetic process|inflammatory response|nitric oxide mediated signal transduction|blood coagulation|response to bacterium|negative regulation of gene expression|peptidyl-cysteine S-nitrosylation|positive regulation of guanylate cyclase activity|regulation of cell proliferation|negative regulation of protein catabolic process|defense response to bacterium|defense response to bacterium|regulation of cellular respiration|negative regulation of blood pressure|positive regulation of vasodilation|regulation of insulin secretion|defense response to Gram-negative bacterium|interaction with host|positive regulation of killing of cells of other organism|oxidation-reduction process|cellular response to lipopolysaccharide|cellular response to interferon-gamma|phagosome maturation|,NADPH-hemoprotein reductase activity|nitric-oxide synthase activity|receptor binding|iron ion binding|protein binding|calmodulin binding|FMN binding|heme binding|tetrahydrobiopterin binding|arginine binding|protein homodimerization activity|flavin adenine dinucleotide binding|NADP binding|,10,-0.2,0.0204,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000019777,HDAC2,histone deacetylase 2,nuclear chromatin|heterochromatin|nucleus|nucleoplasm|replication fork|transcription factor complex|cytoplasm|Sin3 complex|NuRD complex|ESC/E(Z) complex|protein complex|,"negative regulation of transcription from RNA polymerase II promoter|chromatin remodeling|maintenance of chromatin silencing|transcription, DNA-templated|blood coagulation|positive regulation of cell proliferation|epidermal cell differentiation|positive regulation of receptor biosynthetic process|negative regulation of neuron projection development|dendrite development|histone deacetylation|hippocampus development|circadian regulation of gene expression|positive regulation of collagen biosynthetic process|cellular response to heat|response to cocaine|odontogenesis of dentin-containing tooth|response to drug|embryonic digit morphogenesis|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of MHC class II biosynthetic process|negative regulation of cell cycle|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|positive regulation of oligodendrocyte differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of protein kinase B signaling|cardiac muscle cell development|negative regulation of cardiac muscle cell proliferation|regulation of sarcomere organization|hair follicle placode formation|eyelid development in camera-type eye|fungiform papilla formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation of canonical Wnt signaling pathway|regulation of protein deacetylation|negative regulation of intrinsic apoptotic signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|core promoter binding|RNA polymerase II repressing transcription factor binding|chromatin binding|sequence-specific DNA binding transcription factor activity|histone deacetylase activity|protein binding|transcription factor binding|deacetylase activity|enzyme binding|heat shock protein binding|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|sequence-specific DNA binding|poly(A) RNA binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,-0.3,0.0713,10,0,0,0,0,0.885,-8.9,3
ENSMUSG00000015363,TRABD,TraB domain containing,None,None,None,10,0,0,10,0,0,0,0,0.885,-2.9,2
ENSMUSG00000022613,MIOX,myo-inositol oxygenase,cytoplasm|inclusion body|extracellular vesicular exosome|,inositol catabolic process|inositol catabolic process|oxidation-reduction process|,"aldo-keto reductase (NADP) activity|ferric iron binding|oxidoreductase activity, acting on NAD(P)H|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|inositol oxygenase activity|NADP binding|",10,-0.4,0.0835,10,0,0,0,0,0.885,-5.8,2.9
ENSMUSG00000066513,KLK1B4,kallikrein 1-related pepidase b4,intracellular|nucleus|,proteolysis|small GTPase mediated signal transduction|positive regulation of phosphatidylinositol 3-kinase activity|,catalytic activity|serine-type endopeptidase activity|receptor signaling protein activity|growth factor activity|metal ion binding|,10,-1.3,0.217,10,1.3,1.11,0,0,0.885,-3.3,3.8
ENSMUSG00000032293,IREB2,iron-responsive element binding protein 2,cytoplasm|mitochondrion|cytosol|,regulation of translation|protoporphyrinogen IX biosynthetic process|iron ion transport|cellular iron ion homeostasis|aging|post-embryonic development|response to iron(II) ion|osteoclast differentiation|response to retinoic acid|erythrocyte homeostasis|intestinal absorption|cellular response to hypoxia|,"RNA binding|RNA binding|protein binding|iron-responsive element binding|metal ion binding|4 iron, 4 sulfur cluster binding|",10,0,0,10,0,0,0,0,0.885,-3.8,3.2
ENSMUSG00000035944,TTC38,tetratricopeptide repeat domain 38,None,None,None,10,0,0,10,0,0,0,0,0.885,-4.5,3.4
ENSMUSG00000071076,JUND,jun D proto-oncogene,chromatin|nucleus|protein complex|,osteoblast development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|aging|circadian rhythm|response to light stimulus|response to mechanical stimulus|response to organic cyclic compound|response to lipopolysaccharide|response to peptide hormone|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|cellular response to calcium ion|,double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|ligand-dependent nuclear receptor binding|enzyme binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,0,0,10,0,0,0,0,0.885,-6.6,3.8
ENSMUSG00000001870,LTBP1,latent transforming growth factor beta binding protein 1,extracellular region|proteinaceous extracellular matrix|extracellular matrix|extracellular matrix|,transmembrane receptor protein serine/threonine kinase signaling pathway|extracellular matrix organization|sequestering of TGFbeta in extracellular matrix|,transforming growth factor beta-activated receptor activity|calcium ion binding|protein binding|transforming growth factor beta binding|,10,0,0,10,-0.4,0.123,0,0,0.885,-3.8,3.4
ENSMUSG00000030970,CTBP2,C-terminal binding protein 2,nucleus|nucleus|transcriptional repressor complex|cell junction|synapse|,"transcription, DNA-templated|negative regulation of cell proliferation|viral genome replication|negative regulation of transcription, DNA-templated|white fat cell differentiation|oxidation-reduction process|","transcription corepressor activity|protein binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|NAD binding|",10,0,0,10,0,0,0,0,0.885,-6.8,3.5
ENSMUSG00000040537,ADAM22,ADAM metallopeptidase domain 22,integral component of membrane|,proteolysis|cell adhesion|negative regulation of cell adhesion|central nervous system development|adult locomotory behavior|myelination in peripheral nervous system|,metalloendopeptidase activity|integrin binding|protein binding|zinc ion binding|,10,0,0,10,-0.4,0.0957,0,0,0.885,-5.4,3.9
ENSMUSG00000037608,BCLAF1,BCL2-associated transcription factor 1,nucleus|nucleolus|cytoplasm|,"transcription, DNA-templated|apoptotic process|positive regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of DNA-templated transcription, initiation|positive regulation of response to DNA damage stimulus|positive regulation of intrinsic apoptotic signaling pathway|",DNA binding|protein binding|poly(A) RNA binding|,10,1.1,1.09,10,0,0,0,0,0.885,-3.7,4.2
ENSMUSG00000017861,MYBL2,v-myb avian myeloblastosis viral oncogene homolog-like 2,nucleus|nucleoplasm|Myb complex|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle|spindle assembly involved in mitosis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,-3.5,0.384,10,0.3,0.121,0,0,0.885,-6.9,3.7
ENSMUSG00000030336,CD27,CD27 molecule,extracellular region|integral component of plasma membrane|external side of plasma membrane|extracellular vesicular exosome|,cell surface receptor signaling pathway|release of cytoplasmic sequestered NF-kappaB|immunoglobulin mediated immune response|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to ethanol|positive regulation of B cell differentiation|positive regulation of JNK cascade|negative regulation of T cell apoptotic process|extrinsic apoptotic signaling pathway|,transmembrane signaling receptor activity|protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|,10,0.1,0.0183,10,-0.8,0.345,0,0,0.885,-4.9,3.1
ENSMUSG00000020044,TIMP3,TIMP metallopeptidase inhibitor 3,basement membrane|nucleus|extracellular matrix|extracellular vesicular exosome|,visual perception|negative regulation of endopeptidase activity|negative regulation of endopeptidase activity|negative regulation of membrane protein ectodomain proteolysis|cellular response to organic substance|,protein binding|metalloendopeptidase inhibitor activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-3.9,4.1
ENSMUSG00000028955,VAMP3,vesicle-associated membrane protein 3,plasma membrane|integral component of membrane|apical plasma membrane|cell junction|clathrin-coated vesicle|secretory granule|clathrin-coated vesicle membrane|SNARE complex|neuron projection|synapse|recycling endosome|,"positive regulation of receptor recycling|protein complex assembly|exocytosis|vesicle docking involved in exocytosis|vesicle-mediated transport|calcium ion-dependent exocytosis|substrate adhesion-dependent cell spreading|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|membrane fusion|",protein binding|syntaxin-1 binding|,10,0,0,10,-0.2,0.0201,0,0,0.885,-5.1,2
ENSMUSG00000064128,CENPJ,centromere protein J,centrosome|centriole|cytosol|microtubule|gamma-tubulin small complex|,G2/M transition of mitotic cell cycle|mitotic cell cycle|microtubule nucleation|centriole replication|regulation of centriole replication|microtubule polymerization|cell division|,protein binding|tubulin binding|protein kinase binding|protein domain specific binding|,10,0.3,0.136,10,-0.4,0.152,0,0,0.885,-3.1,2.5
ENSMUSG00000014773,DLL1,delta-like 1 (Drosophila),extracellular region|plasma membrane|integral component of plasma membrane|cytoplasmic vesicle|,cell fate determination|somite specification|heart looping|Notch signaling pathway|Notch signaling pathway|Notch signaling pathway|Notch receptor processing|cell-cell signaling|determination of left/right symmetry|compartment pattern specification|hemopoiesis|cell differentiation|regulation of cell adhesion|negative regulation of interleukin-10 production|negative regulation of auditory receptor cell differentiation|negative regulation of myeloid cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|inner ear development|left/right axis specification|proximal tubule development|loop of Henle development|neuronal stem cell maintenance|,Notch binding|calcium ion binding|protein binding|,10,0.4,0.127,10,0,0,0,0,0.885,-6.4,5
ENSMUSG00000020950,FOXG1,forkhead box G1,nucleus|,"positive regulation of neuroblast proliferation|transcription, DNA-templated|regulation of mitotic cell cycle|brain development|aging|dorsal/ventral pattern formation|axon midline choice point recognition|pyramidal neuron migration|inner ear morphogenesis|negative regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|neuron fate determination|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,10,0,0,9,0,0,0,0,0.885,-5.6,3
ENSMUSG00000027208,FGF7,fibroblast growth factor 7,extracellular region|Golgi apparatus|,signal transduction|epidermal growth factor receptor signaling pathway|positive regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|epidermis development|response to wounding|mesenchymal cell proliferation|positive regulation of keratinocyte proliferation|hair follicle morphogenesis|actin cytoskeleton reorganization|protein localization to cell surface|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of keratinocyte migration|positive regulation of cell division|branching involved in salivary gland morphogenesis|positive regulation of epithelial cell proliferation involved in lung morphogenesis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling|secretion by lung epithelial cell involved in lung growth|,fibroblast growth factor receptor binding|protein binding|growth factor activity|heparin binding|chemoattractant activity|,10,-1,0.152,10,0.1,0.00827,0,0,0.885,-8,3.9
ENSMUSG00000000420,GALNT1,polypeptide N-acetylgalactosaminyltransferase 1,Golgi membrane|extracellular region|Golgi apparatus|membrane|integral component of membrane|Golgi cisterna membrane|perinuclear region of cytoplasm|,protein O-linked glycosylation|O-glycan processing|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|manganese ion binding|,0,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000028458,TESK1,testis-specific kinase 1,cytosol|,spermatogenesis|peptidyl-tyrosine phosphorylation|cell junction assembly|,protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|metal ion binding|,10,-0.7,0.643,10,0.1,0.00833,0,0,0.885,-3,6
ENSMUSG00000067158,COL4A4,"collagen, type IV, alpha 4",extracellular region|collagen type IV trimer|basal lamina|endoplasmic reticulum lumen|,axon guidance|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|glomerular basement membrane development|,extracellular matrix structural constituent|,10,-1.5,0.978,10,0,0,0,0,0.885,-5.4,4
ENSMUSG00000021453,GADD45G,"growth arrest and DNA-damage-inducible, gamma",nucleus|cytoplasm|,activation of MAPKKK activity|activation of MAPKK activity|negative regulation of protein kinase activity|apoptotic process|response to stress|multicellular organismal development|cell differentiation|positive regulation of apoptotic process|positive regulation of JNK cascade|regulation of cell cycle|positive regulation of p38MAPK cascade|,protein binding|,10,0,0,10,0.6,0.286,0,0,0.885,-3.2,2.6
ENSMUSG00000034601,2700049A03RIK,RIKEN cDNA 2700049A03 gene,cytoplasm|centrosome|centrosome|cytoskeleton|ciliary basal body|,smoothened signaling pathway|cell projection organization|cilium assembly|cilium morphogenesis|regulation of establishment of protein localization|,protein binding|,10,0,0,10,0.2,0.028,0,0,0.885,-3.5,4.4
ENSMUSG00000030077,CHL1,cell adhesion molecule L1-like,proteinaceous extracellular matrix|plasma membrane|integral component of membrane|dendrite|apical part of cell|,neuron migration|cell adhesion|signal transduction|axon guidance|adult locomotory behavior|exploration behavior|negative regulation of neuron apoptotic process|cognition|,protease binding|,10,0,0,10,0,0,0,0,0.885,-2.1,2
ENSMUSG00000000303,CDH1,"cadherin 1, type 1, E-cadherin (epithelial)",extracellular region|cytoplasm|endosome|trans-Golgi network|plasma membrane|plasma membrane|cell-cell adherens junction|focal adhesion|cytoplasmic side of plasma membrane|cell surface|actin cytoskeleton|integral component of membrane|aggresome|basolateral plasma membrane|lateral plasma membrane|catenin complex|cell junction|cell junction|node of Ranvier|lateral loop|Schmidt-Lanterman incisure|apical junction complex|axon terminus|apical part of cell|perinuclear region of cytoplasm|extracellular vesicular exosome|,"trophectodermal cell differentiation|epithelial cell morphogenesis|apoptotic process|cellular component disassembly involved in execution phase of apoptosis|homophilic cell adhesion|synapse assembly|sensory perception of sound|response to toxic substance|single organismal cell-cell adhesion|protein metabolic process|pituitary gland development|negative regulation of cell-cell adhesion|extracellular matrix disassembly|extracellular matrix organization|neuron projection development|regulation of water loss via skin|cell junction assembly|adherens junction organization|response to drug|positive regulation of transcription factor import into nucleus|regulation of cysteine-type endopeptidase activity involved in apoptotic process|cell-cell junction organization|positive regulation of transcription, DNA-templated|negative regulation of epithelial cell proliferation|regulation of immune response|protein homooligomerization|intestinal epithelial cell development|salivary gland cavitation|regulation of branching involved in salivary gland morphogenesis|tight junction assembly|cellular response to amino acid stimulus|cellular response to lithium ion|cellular response to indole-3-methanol|protein localization to plasma membrane|establishment of protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|cochlea development|regulation of protein localization to cell surface|",glycoprotein binding|calcium ion binding|protein binding|beta-catenin binding|protein phosphatase binding|protein domain specific binding|ankyrin binding|GTPase activating protein binding|gamma-catenin binding|cell adhesion molecule binding|,10,1.5,1.5,10,-0.1,0.0257,0,0,0.885,-5.6,4.5
ENSMUSG00000013415,IGF2BP1,insulin-like growth factor 2 mRNA binding protein 1,nucleus|cytoplasm|cytosol|cytoplasmic stress granule|lamellipodium|filopodium|axon|growth cone|ribonucleoprotein complex|dendritic spine|perinuclear region of cytoplasm|CRD-mediated mRNA stability complex|,gene expression|regulation of mRNA stability involved in response to stress|negative regulation of translation|regulation of cytokine biosynthetic process|mRNA transport|CRD-mediated mRNA stabilization|,nucleotide binding|mRNA binding|mRNA 3'-UTR binding|protein binding|poly(A) RNA binding|translation regulator activity|mRNA 5'-UTR binding|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000034292,TRAF3IP1,TNF receptor-associated factor 3 interacting protein 1,cytoplasm|cytoskeleton|cilium|,None,protein binding|microtubule binding|,1,0,0,1,-0.9,0.127,0,0,0.885,-2,1.8
ENSMUSG00000000903,VPREB3,pre-B lymphocyte 3,endoplasmic reticulum|,None,None,10,-1.9,0.226,9,0.5,0.297,0,0,0.885,-9.6,4.4
ENSMUSG00000024975,PDCD4,programmed cell death 4 (neoplastic transformation inhibitor),nucleus|nucleus|nucleus|cytoplasm|cytosol|,"apoptotic process|cell aging|negative regulation of JUN kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|",RNA binding|protein binding|,10,-0.6,0.294,10,0.2,0.0778,0,0,0.885,-3.3,6.3
ENSMUSG00000015961,ADSS,adenylosuccinate synthase,cytoplasm|cytosol|plasma membrane|,immune system process|purine nucleobase metabolic process|AMP biosynthetic process|AMP biosynthetic process|GTP catabolic process|aspartate metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to purine-containing compound|'de novo' AMP biosynthetic process|small molecule metabolic process|IMP metabolic process|nucleobase-containing small molecule metabolic process|response to ammonium ion|cellular response to electrical stimulus|,magnesium ion binding|adenylosuccinate synthase activity|adenylosuccinate synthase activity|protein binding|GTP binding|phosphate ion binding|,10,-0.4,0.216,10,0,0,0,0,0.885,-2.7,2.9
ENSMUSG00000092243,GM7030,predicted gene 7030,None,None,None,10,-0.4,0.0942,10,0,0,0,0,0.885,-6.5,5.6
ENSMUSG00000040596,POGK,pogo transposable element with KRAB domain,nucleus|,"regulation of transcription, DNA-templated|multicellular organismal development|",DNA binding|protein binding|,10,0,0,10,0,0,0,0,0.885,-3.1,7.4
ENSMUSG00000005413,HMOX1,heme oxygenase (decycling) 1,extracellular space|nucleus|nucleolus|endoplasmic reticulum|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|caveola|membrane|,angiogenesis|endothelial cell proliferation|wound healing involved in inflammatory response|negative regulation of leukocyte migration|porphyrin-containing compound metabolic process|heme oxidation|cellular iron ion homeostasis|response to oxidative stress|small GTPase mediated signal transduction|excretion|regulation of blood pressure|cell death|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of muscle cell apoptotic process|smooth muscle hyperplasia|cellular response to nutrient|negative regulation of mast cell cytokine production|erythrocyte homeostasis|low-density lipoprotein particle clearance|response to nicotine|intracellular signal transduction|heme catabolic process|heme catabolic process|response to hydrogen peroxide|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of mast cell degranulation|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to estrogen|small molecule metabolic process|positive regulation of chemokine biosynthetic process|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of vasodilation|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|protein homooligomerization|iron ion homeostasis|iron ion homeostasis|transmembrane transport|cellular response to arsenic-containing substance|cellular response to cadmium ion|cellular response to hypoxia|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|,heme oxygenase (decyclizing) activity|heme oxygenase (decyclizing) activity|phospholipase D activity|signal transducer activity|enzyme binding|heme binding|protein homodimerization activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.2,1.9
ENSMUSG00000020836,CORO6,coronin 6,actin cytoskeleton|,actin cytoskeleton organization|,actin filament binding|,10,0,0,10,0,0,0,0,0.885,-3.4,2.9
ENSMUSG00000035235,TRIM13,tripartite motif containing 13,cytoplasm|endoplasmic reticulum membrane|integral component of membrane|perinuclear endoplasmic reticulum|,signal transduction|anatomical structure morphogenesis|response to gamma radiation|positive regulation of cell death|positive regulation of macroautophagy|ER-associated ubiquitin-dependent protein catabolic process|negative regulation of viral transcription|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|negative regulation of viral release from host cell|,ubiquitin-protein transferase activity|signal transducer activity|protein binding|zinc ion binding|ligase activity|,10,0,0,10,0.3,0.0222,0,0,0.885,-6.9,4.2
ENSMUSG00000031710,UCP1,"uncoupling protein 1 (mitochondrial, proton carrier)",mitochondrion|mitochondrial inner membrane|integral component of membrane|,regulation of transcription from RNA polymerase II promoter|mitochondrial transport|proton transport|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|brown fat cell differentiation|,oxidative phosphorylation uncoupler activity|,10,-1.1,0.154,10,0.4,0.0698,0,0,0.885,-3.2,2.5
ENSMUSG00000022847,THPO,thrombopoietin,extracellular space|,positive regulation of protein phosphorylation|multicellular organismal development|blood coagulation|cell proliferation|myeloid cell differentiation|platelet activation|thrombopoietin-mediated signaling pathway|positive regulation of megakaryocyte differentiation|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|,cytokine activity|hormone activity|growth factor activity|,10,0,0,10,0.3,0.135,0,0,0.885,-2.1,5.3
ENSMUSG00000048782,INSC,inscuteable homolog (Drosophila),cytoplasm|apical part of cell|,establishment of mitotic spindle orientation|nervous system development|lung epithelial cell differentiation|,None,10,-1.4,0.368,10,0,0,0,0,0.885,-3.8,2.5
ENSMUSG00000038600,ATP6V0A4,"ATPase, H+ transporting, lysosomal V0 subunit a4","vacuolar proton-transporting V-type ATPase, V0 domain|lysosomal membrane|endosome|plasma membrane|endosome membrane|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|brush border membrane|apical part of cell|extracellular vesicular exosome|",ossification|cellular iron ion homeostasis|regulation of pH|excretion|sensory perception of sound|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|proton transport|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|,protein binding|hydrogen ion transmembrane transporter activity|ATPase binding|,10,-1.4,0.0378,10,0,0,0,0,0.885,-4.8,3
ENSMUSG00000029570,LFNG,LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase,extracellular region|integral component of Golgi membrane|,ovarian follicle development|somitogenesis|female meiotic division|Notch signaling pathway|compartment pattern specification|metabolic process|metabolic process|regulation of Notch signaling pathway|organ morphogenesis|regulation of somitogenesis|positive regulation of protein binding|positive regulation of Notch signaling pathway|,molecular_function|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|metal ion binding|,10,0,0,10,-0.6,0.122,0,0,0.885,-4.9,2.3
ENSMUSG00000022996,WNT10B,"wingless-type MMTV integration site family, member 10B",extracellular region|proteinaceous extracellular matrix|extracellular space|,G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|chondrocyte differentiation|lipid metabolic process|cell cycle arrest|smoothened signaling pathway|positive regulation of cell proliferation|positive regulation of G2/M transition of mitotic cell cycle|myoblast differentiation involved in skeletal muscle regeneration|Wnt signaling pathway|neuron differentiation|neuron differentiation|positive regulation of bone mineralization|positive regulation of epithelial cell differentiation|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of skeletal muscle tissue development|skeletal muscle fiber development|negative regulation of epithelial cell proliferation|protein stabilization|sensory perception of taste|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of anagen|canonical Wnt signaling pathway|bone trabecula formation|fungiform papilla development|cellular response to retinoic acid|cellular response to cAMP|cellular response to parathyroid hormone stimulus|hematopoietic stem cell proliferation|cellular response to hydrostatic pressure|positive regulation of canonical Wnt signaling pathway|,frizzled binding|receptor agonist activity|,10,-0.5,0.0948,10,0,0,0,0,0.885,-6.9,2.8
ENSMUSG00000037313,TACC3,"transforming, acidic coiled-coil containing protein 3",cytoplasm|centrosome|,response to hypoxia|cerebral cortex development|neurogenesis|interkinetic nuclear migration|hemopoiesis|astral microtubule organization|regulation of microtubule-based process|cytoplasmic sequestering of transcription factor|regulation of cell cycle|,protein binding|protein domain specific binding|,10,0.2,0.0583,10,-0.4,0.165,0,0,0.885,-5.5,3.2
ENSMUSG00000029287,TGFBR3,"transforming growth factor, beta receptor III",proteinaceous extracellular matrix|extracellular space|extracellular space|endoplasmic reticulum|integral component of plasma membrane|external side of plasma membrane|cell surface|inhibin-betaglycan-ActRII complex|extracellular vesicular exosome|,blood vessel development|response to hypoxia|blastocyst development|epithelial to mesenchymal transition|liver development|heart morphogenesis|immune response|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor complex assembly|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|cell growth|cell migration|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|organ regeneration|response to follicle-stimulating hormone|response to prostaglandin E|response to luteinizing hormone|intracellular signal transduction|regulation of protein binding|negative regulation of epithelial cell proliferation|positive regulation of NF-kappaB transcription factor activity|negative regulation of cellular component movement|ventricular cardiac muscle tissue morphogenesis|palate development|cardiac muscle cell proliferation|definitive hemopoiesis|cardiac epithelial to mesenchymal transition|definitive erythrocyte differentiation|heart trabecula formation|pathway-restricted SMAD protein phosphorylation|,"transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|transforming growth factor beta receptor binding|protein binding|protein binding|glycosaminoglycan binding|glycosaminoglycan binding|heparin binding|coreceptor activity|fibroblast growth factor binding|PDZ domain binding|SMAD binding|activin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|",10,-1.1,1.14,10,0.6,0.351,0,0,0.885,-5.3,3.3
ENSMUSG00000042642,FLAD1,flavin adenine dinucleotide synthetase 1,mitochondrial matrix|cytosol|,FAD biosynthetic process|vitamin metabolic process|water-soluble vitamin metabolic process|riboflavin metabolic process|Mo-molybdopterin cofactor biosynthetic process|small molecule metabolic process|,FMN adenylyltransferase activity|ATP binding|,10,-0.3,0.0189,10,0.9,0.461,0,0,0.885,-3.2,4.7
ENSMUSG00000020333,ACSL6,acyl-CoA synthetase long-chain family member 6,nucleus|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|,response to hypoxia|long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|acyl-CoA metabolic process|neuroblast proliferation|response to nutrient|phospholipid biosynthetic process|response to gravity|positive regulation of plasma membrane long-chain fatty acid transport|positive regulation of triglyceride biosynthetic process|positive regulation of neuron projection development|fatty acid transport|triglyceride biosynthetic process|cellular response to insulin stimulus|long-chain fatty-acyl-CoA biosynthetic process|cellular lipid metabolic process|small molecule metabolic process|response to steroid hormone|neuron development|,long-chain fatty acid-CoA ligase activity|long-chain fatty acid-CoA ligase activity|ATP binding|enzyme binding|protein homodimerization activity|,10,0,0,10,0,0,0,0,0.885,-3.7,5.1
ENSMUSG00000008813,TPPP2,tubulin polymerization-promoting protein family member 2,cytoplasm|,None,None,10,-0.1,0.0159,10,0,0,0,0,0.885,-3.4,3.8
ENSMUSG00000001173,OCRL,oculocerebrorenal syndrome of Lowe,photoreceptor outer segment|nucleus|cytoplasm|early endosome|Golgi stack|Golgi-associated vesicle|trans-Golgi network|cytosol|plasma membrane|coated pit|clathrin-coated vesicle|phagocytic vesicle membrane|early endosome membrane|extracellular vesicular exosome|,in utero embryonic development|lipid metabolic process|phospholipid metabolic process|phosphatidylinositol biosynthetic process|small GTPase mediated signal transduction|regulation of Rac GTPase activity|positive regulation of Rac GTPase activity|cilium assembly|inositol phosphate metabolic process|small molecule metabolic process|phosphatidylinositol dephosphorylation|regulation of small GTPase mediated signal transduction|,"phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding|Rac GTPase activator activity|Rac GTPase binding|inositol phosphate phosphatase activity|",10,-0.4,0.056,10,0,0,0,0,0.885,-4.8,3.8
ENSMUSG00000024026,GLO1,glyoxalase I,cytoplasm|extracellular vesicular exosome|,carbohydrate metabolic process|regulation of transcription from RNA polymerase II promoter|glutathione metabolic process|methylglyoxal metabolic process|osteoclast differentiation|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of apoptotic process|,lactoylglutathione lyase activity|zinc ion binding|,10,0,0,10,1,0.368,0,0,0.885,-7.8,4
ENSMUSG00000025651,UQCRC1,ubiquinol-cytochrome c reductase core protein I,mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial respiratory chain complex III|,"oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|response to activity|respiratory electron transport chain|response to alkaloid|cellular metabolic process|small molecule metabolic process|oxidation-reduction process|hydrogen ion transmembrane transport|",ubiquinol-cytochrome-c reductase activity|protein complex binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.9,3.5
ENSMUSG00000011171,VIPR2,vasoactive intestinal peptide receptor 2,plasma membrane|integral component of plasma membrane|,signal transduction|G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|cell-cell signaling|negative regulation of smooth muscle cell proliferation|,G-protein coupled receptor activity|vasoactive intestinal polypeptide receptor activity|,10,-3.6,0.924,10,0.4,0.264,0,0,0.885,-6.8,3.7
ENSMUSG00000048078,TENM4,teneurin transmembrane protein 4,nucleus|cytoplasm|integral component of plasma membrane|neuron projection|,gastrulation with mouth forming second|signal transduction|positive regulation of myelination|central nervous system myelin formation|neuron development|positive regulation of oligodendrocyte differentiation|cardiac muscle cell proliferation|cardiac cell fate specification|positive regulation of gastrulation|,protein homodimerization activity|,10,0,0,10,0,0,0,0,0.885,-3,3.4
ENSMUSG00000020321,MDH1,"malate dehydrogenase 1, NAD (soluble)",extracellular space|cytoplasm|mitochondrion|centrosome|cytosol|extracellular vesicular exosome|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|cellular carbohydrate metabolic process|small molecule metabolic process|,malic enzyme activity|L-malate dehydrogenase activity|diiodophenylpyruvate reductase activity|NAD binding|,10,0,0,10,-0.4,0.138,0,0,0.885,-3.5,2.9
ENSMUSG00000004098,COL5A3,"collagen, type V, alpha 3",extracellular region|collagen type V trimer|endoplasmic reticulum lumen|extracellular vesicular exosome|,cell-matrix adhesion|axon guidance|extracellular matrix disassembly|extracellular matrix organization|collagen fibril organization|collagen catabolic process|skin development|,extracellular matrix structural constituent|collagen binding|heparin binding|proteoglycan binding|,10,1.4,0.133,10,0,0,0,0,0.885,-8.1,6
ENSMUSG00000024393,PRRC2A,proline-rich coiled-coil 2A,nucleus|cytoplasm|membrane|extracellular vesicular exosome|,None,protein binding|poly(A) RNA binding|,10,0,0,10,-0.5,0.14,0,0,0.885,-3,3.3
ENSMUSG00000024212,MLLT1,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1",nucleus|nucleolus|cytoplasm|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of protein kinase activity|",DNA binding|protein binding|,10,-2.6,1.09,9,0,0,0,0,0.885,-8.4,3.4
ENSMUSG00000030730,ATP2A1,"ATPase, Ca++ transporting, cardiac muscle, fast twitch 1",endoplasmic reticulum membrane|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|membrane|integral component of membrane|sarcoplasmic reticulum|sarcoplasmic reticulum|platelet dense tubular network membrane|H zone|I band|sarcoplasmic reticulum membrane|sarcoplasmic reticulum membrane|calcium channel complex|perinuclear region of cytoplasm|,ATP catabolic process|calcium ion transport|calcium ion transport|regulation of striated muscle contraction|blood coagulation|metabolic process|apoptotic mitochondrial changes|positive regulation of fast-twitch skeletal muscle fiber contraction|positive regulation of endoplasmic reticulum calcium ion concentration|negative regulation of endoplasmic reticulum calcium ion concentration|ion transmembrane transport|response to endoplasmic reticulum stress|negative regulation of striated muscle contraction|positive regulation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|transmembrane transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion import|calcium ion transmembrane transport|relaxation of skeletal muscle|,calcium-transporting ATPase activity|calcium ion binding|calcium ion binding|protein binding|ATP binding|ATP binding|protein homodimerization activity|,1,0,0,0,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000002799,JAG2,jagged 2,plasma membrane|integral component of plasma membrane|,skeletal system development|in utero embryonic development|respiratory system process|cell cycle|Notch signaling pathway|Notch signaling pathway|Notch receptor processing|spermatogenesis|auditory receptor cell fate commitment|morphogenesis of embryonic epithelium|cell differentiation|regulation of cell adhesion|T cell differentiation|regulation of cell migration|regulation of cell proliferation|odontogenesis of dentin-containing tooth|gamma-delta T cell differentiation|thymic T cell selection|epithelial cell apoptotic process involved in palatal shelf morphogenesis|,Notch binding|calcium ion binding|protein binding|growth factor activity|,10,0,0,10,0,0,0,0,0.885,-3,2.7
ENSMUSG00000047492,INHBE,"inhibin, beta E",extracellular region|,growth|,hormone activity|growth factor activity|,10,0,0,10,0,0,0,0,0.885,-8,3
ENSMUSG00000030096,SLC6A6,"solute carrier family 6 (neurotransmitter transporter), member 6",plasma membrane|integral component of plasma membrane|integral component of membrane|,cellular amino acid metabolic process|transport|ion transport|neurotransmitter transport|amino acid transport|taurine transport|transmembrane transport|,neurotransmitter:sodium symporter activity|taurine:sodium symporter activity|taurine binding|,10,-0.2,0.0485,10,-1.6,0.0611,0,0,0.885,-6.1,2.7
ENSMUSG00000022114,SPRY2,sprouty homolog 2 (Drosophila),cytosol|microtubule|plasma membrane|ruffle membrane|,epidermal growth factor receptor signaling pathway|sensory perception of sound|negative regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|negative regulation of peptidyl-threonine phosphorylation|positive regulation of peptidyl-serine phosphorylation|negative regulation of Ras GTPase activity|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of MAP kinase activity|cell fate commitment|negative regulation of Ras protein signal transduction|branching morphogenesis of an epithelial tube|negative regulation of neurotrophin TRK receptor signaling pathway|positive regulation of protein kinase B signaling|lung morphogenesis|lung growth|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|,protein binding|protein kinase binding|protein serine/threonine kinase inhibitor activity|protein serine/threonine kinase activator activity|,10,0,0,10,0,0,0,0,0.885,-6.4,3
ENSMUSG00000022475,HDAC7,histone deacetylase 7,histone deacetylase complex|nucleus|nucleoplasm|cytoplasm|,"negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|transcription, DNA-templated|cell-cell junction assembly|Notch signaling pathway|negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|histone H3 deacetylation|histone H4 deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|",chromatin binding|transcription corepressor activity|protein kinase C binding|protein binding|protein kinase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|activating transcription factor binding|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|repressing transcription factor binding|14-3-3 protein binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000047757,FANCB,"Fanconi anemia, complementation group B",nucleoplasm|Fanconi anaemia nuclear complex|,DNA repair|,protein binding|,10,0,0,10,-0.1,0.0201,0,0,0.885,-7.2,3.5
ENSMUSG00000008305,TLE1,"transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)",nucleus|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|signal transduction|Notch signaling pathway|multicellular organismal development|organ morphogenesis|positive regulation of gene expression|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|negative regulation of anoikis|",RNA polymerase II transcription corepressor activity|chromatin binding|protein binding|transcription factor binding|transcription factor binding|,10,0.5,0.108,10,0,0,0,0,0.885,-2.9,3.5
ENSMUSG00000017697,ADA,adenosine deaminase,extracellular space|cytoplasm|lysosome|cytosol|plasma membrane|external side of plasma membrane|cell surface|membrane|cell junction|dendrite cytoplasm|neuronal cell body|cytoplasmic membrane-bounded vesicle lumen|,"response to hypoxia|histamine secretion|trophectodermal cell differentiation|liver development|placenta development|germinal center B cell differentiation|positive regulation of germinal center formation|negative regulation of leukocyte migration|negative regulation of mature B cell apoptotic process|purine nucleobase metabolic process|adenosine catabolic process|adenosine catabolic process|deoxyadenosine catabolic process|cell adhesion|aging|purine ribonucleoside monophosphate biosynthetic process|positive regulation of heart rate|positive regulation of B cell proliferation|purine nucleotide salvage|positive regulation of T cell differentiation in thymus|response to vitamin E|regulation of cell-cell adhesion mediated by integrin|T cell activation|negative regulation of circadian sleep/wake cycle, non-REM sleep|response to drug|response to hydrogen peroxide|purine-containing compound salvage|hypoxanthine salvage|response to morphine|small molecule metabolic process|positive regulation of smooth muscle contraction|dATP catabolic process|inosine biosynthetic process|inosine biosynthetic process|xanthine biosynthetic process|positive regulation of alpha-beta T cell differentiation|lung alveolus development|Peyer's patch development|embryonic digestive tract development|negative regulation of inflammatory response|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|nucleobase-containing small molecule metabolic process|negative regulation of adenosine receptor signaling pathway|negative regulation of penile erection|negative regulation of thymocyte apoptotic process|negative regulation of mucus secretion|",purine nucleoside binding|adenosine deaminase activity|adenosine deaminase activity|protein binding|zinc ion binding|zinc ion binding|,10,0,0,10,-1,0.391,0,0,0.885,-8.1,2.3
ENSMUSG00000062510,NSL1,"NSL1, MIS12 kinetochore complex component",MIS12/MIND type complex|nucleus|cytosol|,mitotic cell cycle|chromosome segregation|mitotic nuclear division|,protein binding|,9,-0.1,0.0164,8,0,0,0,0,0.885,-7.7,2
ENSMUSG00000071937,ADAM25,a disintegrin and metallopeptidase domain 25 (testase 2),cellular_component|membrane|integral component of membrane|,proteolysis|multicellular organismal development|spermatogenesis|cell differentiation|,metalloendopeptidase activity|integrin binding|peptidase activity|metallopeptidase activity|zinc ion binding|hydrolase activity|metal ion binding|,10,-0.6,0.203,10,0.2,0.0959,0,0,0.885,-6.7,3.6
ENSMUSG00000096883,AI848285,N/A,None,None,None,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000062181,CES3B,carboxylesterase 3B,endoplasmic reticulum|extracellular vesicular exosome|,biological_process|,hydrolase activity|carboxylic ester hydrolase activity|,10,0,0,10,0,0,0,0,0.885,-2.7,2.3
ENSMUSG00000031538,PLAT,"plasminogen activator, tissue",extracellular region|extracellular space|cytoplasm|cell surface|secretory granule|apical part of cell|synapse|extracellular vesicular exosome|,"response to hypoxia|cellular protein modification process|proteolysis|blood coagulation|smooth muscle cell migration|plasminogen activation|synaptic transmission, glutamatergic|fibrinolysis|response to peptide hormone|negative regulation of proteolysis|platelet-derived growth factor receptor signaling pathway|regulation of synaptic plasticity|response to glucocorticoid|response to cAMP|positive regulation of ovulation|",serine-type endopeptidase activity|serine-type endopeptidase activity|protein binding|,10,-0.5,0.273,10,0.2,0.0463,0,0,0.885,-3.9,1.9
ENSMUSG00000022548,APOD,apolipoprotein D,extracellular region|extracellular space|endoplasmic reticulum|cytosolic ribosome|dendrite|neuronal cell body|perinuclear region of cytoplasm|extracellular vesicular exosome|,response to reactive oxygen species|angiogenesis|glucose metabolic process|lipid metabolic process|lipid transport|brain development|aging|negative regulation of platelet-derived growth factor receptor signaling pathway|peripheral nervous system axon regeneration|tissue regeneration|negative regulation of protein import into nucleus|response to drug|negative regulation of smooth muscle cell proliferation|response to axon injury|negative regulation of focal adhesion assembly|negative regulation of lipoprotein lipid oxidation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of cytokine production involved in inflammatory response|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of T cell migration|,lipid transporter activity|protein binding|cholesterol binding|,10,0,0,10,0,0,0,0,0.885,-8.7,5
ENSMUSG00000041653,PNPLA3,patatin-like phospholipase domain containing 3,endoplasmic reticulum membrane|membrane|integral component of membrane|,phospholipid metabolic process|triglyceride biosynthetic process|triglyceride catabolic process|triglyceride catabolic process|acylglycerol acyl-chain remodeling|small molecule metabolic process|glycerophospholipid biosynthetic process|,phospholipase A2 activity|triglyceride lipase activity|mono-olein transacylation activity|diolein transacylation activity|,10,-2.3,1.49,10,3.7,0.0339,0,0,0.885,-6.4,7.2
ENSMUSG00000042275,PELO,pelota homolog (Drosophila),nucleus|cytoplasm|,"cell cycle|cell proliferation|chromosome organization|cell division|nuclear-transcribed mRNA catabolic process, non-stop decay|nuclear-transcribed mRNA catabolic process, no-go decay|RNA surveillance|nucleic acid phosphodiester bond hydrolysis|",endonuclease activity|metal ion binding|,10,0,0,10,-0.1,0.0173,0,0,0.885,-3.2,1.7
ENSMUSG00000024927,RELA,v-rel avian reticuloendotheliosis viral oncogene homolog A,nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|liver development|hair follicle development|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|acetaldehyde metabolic process|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|inflammatory response|cellular defense response|aging|positive regulation of cell proliferation|response to mechanical stimulus|organ morphogenesis|response to organic substance|response to UV-B|positive regulation of Schwann cell differentiation|viral process|cytokine-mediated signaling pathway|membrane protein intracellular domain proteolysis|positive regulation of chondrocyte differentiation|positive regulation of type I interferon production|response to muramyl dipeptide|response to progesterone|response to insulin|response to cobalamin|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of protein catabolic process|response to drug|negative regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|response to morphine|positive regulation of interleukin-12 biosynthetic process|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of insulin receptor signaling pathway|neurotrophin TRK receptor signaling pathway|regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|response to cAMP|defense response to virus|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing 2 signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to peptide hormone stimulus|positive regulation of miRNA metabolic process|negative regulation of extrinsic apoptotic signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein kinase binding|ubiquitin protein ligase binding|protein complex binding|activating transcription factor binding|phosphate ion binding|identical protein binding|identical protein binding|transcription regulatory region DNA binding|protein N-terminus binding|NF-kappaB binding|repressing transcription factor binding|ankyrin repeat binding|,10,0,0,10,0,0,0,0,0.885,-6.4,1.8
ENSMUSG00000030505,PRMT3,protein arginine methyltransferase 3,cytoplasm|cytosol|ribosome|,"regulation of transcription, DNA-templated|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|negative regulation of protein ubiquitination|histone arginine methylation|",protein binding|methyltransferase activity|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|metal ion binding|modified amino acid binding|,10,0,0,10,0.2,0.0765,0,0,0.885,-2.1,2
ENSMUSG00000063063,CTNNA2,"catenin (cadherin-associated protein), alpha 2",cytoplasm|cytosol|adherens junction|cell-cell adherens junction|actin cytoskeleton|basolateral plasma membrane|lamellipodium|axon|,axonogenesis|single organismal cell-cell adhesion|radial glia guided migration of Purkinje cell|muscle cell differentiation|dendrite morphogenesis|brain morphogenesis|positive regulation of muscle cell differentiation|regulation of synapse structural plasticity|prepulse inhibition|,structural constituent of cytoskeleton|protein binding|cadherin binding|,10,-0.2,0.0153,10,0.1,0.00924,0,0,0.885,-3.1,2.5
ENSMUSG00000009633,G0S2,G0/G1 switch 2,mitochondrion|lipid particle|,cellular lipid metabolic process|small molecule metabolic process|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|,molecular_function|protein binding|,10,0,0,10,0.7,0.297,0,0,0.885,-8.7,4.6
ENSMUSG00000089762,IER5L,immediate early response 5-like,None,None,None,10,-0.3,0.0553,10,0,0,0,0,0.885,-3.6,2
ENSMUSG00000052139,BRE,brain and reproductive organ-expressed (TNFRSF1A modulator),nuclear ubiquitin ligase complex|nucleus|cytoplasm|BRCA1-A complex|BRISC complex|,double-strand break repair|apoptotic process|cellular response to DNA damage stimulus|signal transduction|response to ionizing radiation|chromatin modification|G2 DNA damage checkpoint|positive regulation of DNA repair|,peroxisome targeting sequence binding|tumor necrosis factor receptor binding|protein binding|polyubiquitin binding|,10,-0.2,0.046,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000020329,POLRMT,polymerase (RNA) mitochondrial (DNA directed),mitochondrion|mitochondrial matrix|mitochondrial nucleoid|,transcription from mitochondrial promoter|transcription from mitochondrial promoter|transcription initiation from mitochondrial promoter|gene expression|,DNA binding|DNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity|protein binding|poly(A) RNA binding|,10,0.1,0.0228,10,0,0,0,0,0.885,-2,2.6
ENSMUSG00000023959,CLIC5,chloride intracellular channel 5,Golgi apparatus|Golgi apparatus|microtubule organizing center|cell cortex|actin cytoskeleton|stereocilium|chloride channel complex|extracellular vesicular exosome|,diet induced thermogenesis|transport|chloride transport|female pregnancy|sensory perception of sound|protein localization|regulation of ion transmembrane transport|regulation of anion transport|neuromuscular process controlling balance|auditory receptor cell stereocilium organization|chloride transmembrane transport|,voltage-gated chloride channel activity|protein binding|,10,0.2,0.0414,10,0,0,0,0,0.885,-4.9,3.2
ENSMUSG00000022883,ROBO1,"roundabout, axon guidance receptor, homolog 1 (Drosophila)",cytoplasm|plasma membrane|integral component of plasma membrane|cell surface|axolemma|,cell migration involved in sprouting angiogenesis|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|homophilic cell adhesion|nervous system development|axon guidance|axon midline choice point recognition|chemorepulsion involved in postnatal olfactory bulb interneuron migration|negative regulation of mammary gland epithelial cell proliferation|Roundabout signaling pathway|positive regulation of axonogenesis|negative regulation of negative chemotaxis|mammary duct terminal end bud growth|negative regulation of chemokine-mediated signaling pathway|,protein binding|axon guidance receptor activity|LRR domain binding|identical protein binding|protein heterodimerization activity|,10,-2.1,1.16,10,0,0,0,0,0.885,-5,3.1
ENSMUSG00000026875,TRAF1,TNF receptor-associated factor 1,cytoplasm|,protein complex assembly|apoptotic process|signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of NF-kappaB transcription factor activity|regulation of extrinsic apoptotic signaling pathway|,tumor necrosis factor receptor binding|protein binding|zinc ion binding|ubiquitin protein ligase binding|thioesterase binding|,9,0.2,0.0524,10,-0.2,0.0392,0,0,0.885,-6,2.8
ENSMUSG00000056501,CEBPB,"CCAAT/enhancer binding protein (C/EBP), beta",nuclear chromatin|nucleus|nucleoplasm|cytoplasm|nuclear matrix|,"embryonic placenta development|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|acute-phase response|inflammatory response|immune response|neuron differentiation|response to lipopolysaccharide|mammary gland epithelial cell proliferation|response to endoplasmic reticulum stress|negative regulation of neuron apoptotic process|regulation of interleukin-6 biosynthetic process|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|brown fat cell differentiation|mammary gland epithelial cell differentiation|regulation of transcription involved in cell fate commitment|cellular response to amino acid stimulus|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|glucocorticoid receptor binding|protein homodimerization activity|sequence-specific DNA binding|protein heterodimerization activity|,10,-0.2,0.0452,10,0.5,0.165,0,0,0.885,-2.9,2
ENSMUSG00000063903,KLK1,kallikrein 1,nucleus|extracellular vesicular exosome|,proteolysis|,serine-type endopeptidase activity|,10,3.7,0.424,10,0,0,0,0,0.885,-7.7,7.7
ENSMUSG00000059447,HADHB,"hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit",mitochondrion|mitochondrial envelope|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial inner membrane|endoplasmic reticulum|mitochondrial fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|extracellular vesicular exosome|,fatty acid beta-oxidation|fatty acid beta-oxidation|phospholipid metabolic process|cardiolipin acyl-chain remodeling|cellular lipid metabolic process|small molecule metabolic process|glycerophospholipid biosynthetic process|,fatty-acyl-CoA binding|3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding|long-chain-enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein complex binding|poly(A) RNA binding|NAD binding|,8,0,0,10,0,0,0,0,0.885,-2.4,1.9
ENSMUSG00000075394,HOXC4,homeobox C4,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organismal development|",sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|,1,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000009863,SDHB,"succinate dehydrogenase complex, subunit B, iron sulfur (Ip)",mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex II|extracellular vesicular exosome|,tricarboxylic acid cycle|tricarboxylic acid cycle|succinate metabolic process|aerobic respiration|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|,"protein binding|succinate dehydrogenase (ubiquinone) activity|electron carrier activity|metal ion binding|ubiquinone binding|2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|",10,0,0,10,0.5,0.163,0,0,0.885,-3,2.7
ENSMUSG00000069036,SRY,sex determining region Y,nucleus|nucleus|cytoplasm|nuclear speck|,"regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|sex differentiation|cell differentiation|male sex determination|positive regulation of transcription, DNA-templated|positive regulation of male gonad development|",DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|calmodulin binding|transcription factor binding|,10,0,0,10,0.1,0.00723,0,0,0.885,-8.6,4
ENSMUSG00000003731,KPNA6,karyopherin alpha 6 (importin alpha 7),nucleus|cytoplasm|membrane|,NLS-bearing protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|maternal process involved in female pregnancy|,protein transporter activity|,10,0,0,10,0,0,0,0,0.885,-3.6,2
ENSMUSG00000021835,BMP4,bone morphogenetic protein 4,extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|,"negative regulation of transcription from RNA polymerase II promoter|activation of MAPKK activity|osteoblast differentiation|ureteric bud development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|neural tube closure|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|endochondral ossification|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|chondrocyte differentiation|hematopoietic progenitor cell differentiation|lymphoid progenitor cell differentiation|renal system process|BMP signaling pathway involved in heart induction|secondary heart field specification|endocardial cushion development|cardiac septum development|type B pancreatic cell development|mesenchymal to epithelial transition involved in metanephros morphogenesis|common-partner SMAD protein phosphorylation|smoothened signaling pathway|germ cell development|mesodermal cell fate determination|negative regulation of cell proliferation|post-embryonic development|anterior/posterior axis specification|specification of organ position|regulation of cell fate commitment|positive regulation of endothelial cell migration|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell death|telencephalon development|dorsal/ventral neural tube patterning|telencephalon regionalization|pituitary gland development|extracellular matrix organization|erythrocyte differentiation|monocyte differentiation|macrophage differentiation|positive regulation of bone mineralization|BMP signaling pathway|BMP signaling pathway|positive regulation of BMP signaling pathway|positive regulation of protein binding|negative regulation of chondrocyte differentiation|positive regulation of collagen biosynthetic process|negative regulation of T cell differentiation in thymus|negative regulation of immature T cell proliferation in thymus|protein localization to nucleus|embryonic hindlimb morphogenesis|tendon cell differentiation|deltoid tuberosity development|negative regulation of phosphorylation|odontogenesis of dentin-containing tooth|odontogenesis|regulation of odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|positive regulation of apoptotic process|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|negative regulation of MAP kinase activity|positive regulation of endothelial cell differentiation|positive regulation of epidermal cell differentiation|negative regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of mitosis|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|lung alveolus development|intermediate mesodermal cell differentiation|positive regulation of smooth muscle cell proliferation|neuron fate commitment|embryonic cranial skeleton morphogenesis|smooth muscle tissue development|branching morphogenesis of an epithelial tube|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive chemotaxis|regulation of smooth muscle cell differentiation|positive regulation of cardiac muscle fiber development|inner ear receptor cell differentiation|cloacal septation|lens induction in camera-type eye|embryonic skeletal joint morphogenesis|cranial suture morphogenesis|positive regulation of SMAD protein import into nucleus|regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|lung morphogenesis|bronchus development|trachea development|trachea formation|epithelial tube branching involved in lung morphogenesis|branching involved in prostate gland morphogenesis|bud elongation involved in lung branching|epithelial cell proliferation involved in lung morphogenesis|bud dilation involved in lung branching|negative regulation of cell death|mammary gland formation|epithelial-mesenchymal cell signaling|negative regulation of prostatic bud formation|regulation of branching involved in prostate gland morphogenesis|positive regulation of cartilage development|positive regulation of branching involved in lung morphogenesis|BMP signaling pathway involved in ureter morphogenesis|BMP signaling pathway involved in renal system segmentation|pulmonary artery endothelial tube morphogenesis|negative regulation of thymocyte apoptotic process|positive regulation of ERK1 and ERK2 cascade|cellular response to growth factor stimulus|BMP signaling pathway involved in nephric duct formation|renal system development|glomerular visceral epithelial cell development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|glomerular capillary formation|negative regulation of glomerular mesangial cell proliferation|mesenchymal cell proliferation involved in ureteric bud development|mesenchymal cell differentiation involved in kidney development|ureter epithelial cell differentiation|ureter smooth muscle cell differentiation|mesenchymal cell proliferation involved in ureter development|negative regulation of mesenchymal cell proliferation involved in ureter development|metanephric collecting duct development|positive regulation of kidney development|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of glomerulus development|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of metanephric comma-shaped body morphogenesis|positive regulation of DNA-dependent DNA replication|negative regulation of cell proliferation involved in heart morphogenesis|",cytokine activity|protein binding|growth factor activity|heparin binding|chemoattractant activity|BMP receptor binding|,10,0,0,10,0,0,0,0,0.885,-3.5,2
ENSMUSG00000026420,IL24,interleukin 24,extracellular space|endoplasmic reticulum|,apoptotic process|positive regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of cell migration|serine phosphorylation of STAT3 protein|wound healing|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to lipopolysaccharide|cellular response to interleukin-4|,cytokine activity|,10,0.2,0.0329,10,-0.1,0.00818,0,0,0.885,-2.8,2
ENSMUSG00000027869,HSD3B6,"hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6",mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|membrane|integral component of membrane|,steroid biosynthetic process|metabolic process|oxidation-reduction process|,"C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|catalytic activity|3-beta-hydroxy-delta5-steroid dehydrogenase activity|aldo-keto reductase (NADP) activity|isocitrate dehydrogenase activity|mevaldate reductase activity|steroid delta-isomerase activity|gluconate dehydrogenase activity|steroid dehydrogenase activity|oxidoreductase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|isomerase activity|epoxide dehydrogenase activity|5-exo-hydroxycamphor dehydrogenase activity|2-hydroxytetrahydrofuran dehydrogenase activity|acetoin dehydrogenase activity|phenylcoumaran benzylic ether reductase activity|D-xylose:NADP reductase activity|L-arabinose:NADP reductase activity|D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity|steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|steroid dehydrogenase activity, acting on the CH-CH group of donors|(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity|3-hydroxymenthone dehydrogenase activity|very long-chain-3-hydroxyacyl-CoA dehydrogenase activity|dihydrotestosterone 17-beta-dehydrogenase activity|(R)-2-hydroxyisocaproate dehydrogenase activity|L-arabinose 1-dehydrogenase (NADP+) activity|L-xylulose reductase (NAD+) activity|3-ketoglucose-reductase activity|(R)-2-hydroxyglutarate dehydrogenase activity|D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity|",10,0.6,0.0731,10,-0.4,0.138,0,0,0.885,-6.4,5.4
ENSMUSG00000019489,CD70,CD70 molecule,extracellular space|plasma membrane|integral component of plasma membrane|extracellular vesicular exosome|,immune response|signal transduction|cell-cell signaling|cell proliferation|extrinsic apoptotic signaling pathway|,protease binding|receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|,10,0,0,10,0,0,0,0,0.885,-3.4,2.3
ENSMUSG00000007050,LSM2,"LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)",nucleoplasm|cytosol|catalytic step 2 spliceosome|,"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA splicing|gene expression|RNA metabolic process|mRNA metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|",protein binding|U6 snRNA binding|protein kinase binding|poly(A) RNA binding|,1,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000022130,TGDS,"TDP-glucose 4,6-dehydratase",None,nucleotide-sugar metabolic process|,"dTDP-glucose 4,6-dehydratase activity|coenzyme binding|",10,-0.1,0.0027,10,0,0,0,0,0.885,-3.1,3.2
ENSMUSG00000052713,ZFP608,zinc finger protein 608,None,biological_process|,metal ion binding|,10,0,0,10,0,0,0,0,0.885,-3.4,3
ENSMUSG00000045691,THTPA,thiamine triphosphatase,cytosol|,generation of precursor metabolites and energy|vitamin metabolic process|water-soluble vitamin metabolic process|thiamine metabolic process|dephosphorylation|thiamine diphosphate metabolic process|thiamine-containing compound metabolic process|small molecule metabolic process|,magnesium ion binding|hydrolase activity|thiamin-triphosphatase activity|thiamin-triphosphatase activity|,10,0,0,10,0.5,0.186,0,0,0.885,-3.3,6.5
ENSMUSG00000058833,2810428I15RIK,RIKEN cDNA 2810428I15 gene,cellular_component|,biological_process|,molecular_function|,10,0,0,10,-0.5,0.105,0,0,0.885,-3,1.9
ENSMUSG00000014599,CSF1,colony stimulating factor 1 (macrophage),extracellular space|plasma membrane|membrane|integral component of membrane|receptor complex|perinuclear region of cytoplasm|extracellular vesicular exosome|,ossification|positive regulation of cell-matrix adhesion|osteoclast proliferation|developmental process involved in reproduction|inflammatory response|cell proliferation|positive regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of gene expression|regulation of macrophage derived foam cell differentiation|positive regulation of macrophage derived foam cell differentiation|hemopoiesis|cell differentiation|macrophage differentiation|regulation of ossification|osteoclast differentiation|positive regulation of cell migration|positive regulation of cellular protein metabolic process|positive regulation of mononuclear cell proliferation|positive regulation of multicellular organism growth|monocyte activation|odontogenesis|positive regulation of odontogenesis of dentin-containing tooth|innate immune response|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of Ras protein signal transduction|homeostasis of number of cells within a tissue|branching involved in mammary gland duct morphogenesis|mammary gland fat development|mammary duct terminal end bud growth|,cytokine activity|macrophage colony-stimulating factor receptor binding|macrophage colony-stimulating factor receptor binding|growth factor activity|growth factor activity|protein homodimerization activity|,10,-4,1.58,10,0,0,0,0,0.885,-8.9,6.6
ENSMUSG00000069135,FGFR1OP,FGFR1 oncogene partner,nucleus|centrosome|cytosol|perinuclear region of cytoplasm|,G2/M transition of mitotic cell cycle|mitotic cell cycle|negative regulation of protein kinase activity|positive regulation of cell proliferation|peptidyl-tyrosine phosphorylation|positive regulation of cell growth|positive regulation of cell migration|microtubule anchoring|negative regulation of protein tyrosine kinase activity|,protein tyrosine kinase activity|protein binding|protein kinase binding|protein tyrosine kinase inhibitor activity|protein homodimerization activity|,10,0,0,10,0,0,0,0,0.885,-8.4,2
ENSMUSG00000026603,SMYD2,SET and MYND domain containing 2,nucleus|cytoplasm|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|negative regulation of cell proliferation|histone H3-K36 methylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|regulation of DNA damage response, signal transduction by p53 class mediator|",RNA polymerase II core binding|p53 binding|protein binding|protein-lysine N-methyltransferase activity|metal ion binding|histone methyltransferase activity (H3-K36 specific)|,10,0,0,10,0,0,0,0,0.885,-9.7,4
ENSMUSG00000005442,CIC,capicua transcriptional repressor,nucleus|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",DNA binding|protein binding|,10,0,0,10,0,0,0,0,0.885,-1.9,2.3
ENSMUSG00000036940,KDM1A,lysine (K)-specific demethylase 1A,nuclear chromatin|nuclear chromatin|nucleus|nucleoplasm|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein demethylation|blood coagulation|cell proliferation|regulation of primitive erythrocyte differentiation|pituitary gland development|granulocyte differentiation|negative regulation of protein binding|histone H3-K9 demethylation|histone H3-K4 demethylation|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hormone biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|muscle cell development|oxidation-reduction process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of neural precursor cell proliferation|positive regulation of stem cell proliferation|",RNA polymerase II transcription factor binding|p53 binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|oxidoreductase activity|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|demethylase activity|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|MRF binding|transcription regulatory region DNA binding|flavin adenine dinucleotide binding|androgen receptor binding|,9,0.2,0.0334,10,0,0,0,0,0.885,-3,3.3
ENSMUSG00000029468,P2RX7,"purinergic receptor P2X, ligand-gated ion channel, 7",integral component of nuclear inner membrane|cytoplasm|plasma membrane|plasma membrane|integral component of plasma membrane|membrane|bleb|,"regulation of sodium ion transport|cation transport|cell surface receptor signaling pathway|positive regulation of calcium ion transport into cytosol|sensory perception of pain|positive regulation of bone mineralization|bleb assembly|response to ATP|ion transmembrane transport|purinergic nucleotide receptor signaling pathway|purinergic nucleotide receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|negative regulation of MAPK cascade|innate immune response|negative regulation of bone resorption|positive regulation of cytolysis|pore complex assembly|positive regulation of interleukin-1 beta secretion|positive regulation of cytoskeleton organization|regulation of killing of cells of other organism|membrane depolarization|apoptotic signaling pathway|",lipopolysaccharide binding|purinergic nucleotide receptor activity|extracellular ATP-gated cation channel activity|receptor binding|ATP binding|protein homodimerization activity|,10,0,0,10,-0.2,0.0528,0,0,0.885,-6.4,3.9
ENSMUSG00000054793,CADM4,cell adhesion molecule 4,integral component of membrane|extracellular vesicular exosome|,cell adhesion|,None,10,0.3,0.125,10,0,0,0,0,0.885,-3.9,4.1
ENSMUSG00000024529,LOX,lysyl oxidase,extracellular region|proteinaceous extracellular matrix|collagen trimer|extracellular space|nucleus|,blood vessel development|cellular protein modification process|extracellular matrix organization|collagen fibril organization|lung development|wound healing|response to drug|elastic fiber assembly|response to steroid hormone|oxidation-reduction process|,protein-lysine 6-oxidase activity|copper ion binding|protein binding|,10,-0.2,0.0456,10,0,0,0,0,0.885,-2,2.7
ENSMUSG00000022477,ACO2,"aconitase 2, mitochondrial",nucleus|mitochondrion|mitochondrial matrix|,generation of precursor metabolites and energy|tricarboxylic acid cycle|tricarboxylic acid cycle|tricarboxylic acid cycle|citrate metabolic process|isocitrate metabolic process|cell death|cellular metabolic process|small molecule metabolic process|,"aconitate hydratase activity|iron ion binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|",10,2.2,0.881,10,0,0,0,0,0.885,-8.6,6.8
ENSMUSG00000049470,AFF4,"AF4/FMR2 family, member 4",nucleus|nucleolus|mitochondrion|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|spermatid development|",sequence-specific DNA binding transcription factor activity|protein binding|,10,-2,0.171,10,0,0,0,0,0.885,-4.8,6.6
ENSMUSG00000001496,NKX2-1,NK2 homeobox 1,nucleus|nucleoplasm|transcription factor complex|,"negative regulation of transcription from RNA polymerase II promoter|neuron migration|transcription from RNA polymerase II promoter|phospholipid metabolic process|axon guidance|brain development|endoderm development|locomotory behavior|response to hormone|positive regulation of gene expression|negative regulation of epithelial to mesenchymal transition|globus pallidus development|hippocampus development|cerebral cortex cell migration|forebrain dorsal/ventral pattern formation|forebrain neuron fate commitment|cerebral cortex GABAergic interneuron differentiation|pituitary gland development|lung development|negative regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|thyroid gland development|thyroid gland development|forebrain development|developmental induction|Leydig cell differentiation|menarche|positive regulation of circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|anatomical structure formation involved in morphogenesis|oligodendrocyte differentiation|lung saccule development|epithelial tube branching involved in lung morphogenesis|Clara cell differentiation|Type II pneumocyte differentiation|",core promoter binding|DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|enzyme binding|sequence-specific DNA binding|transcription regulatory region DNA binding|,10,-1.1,0.776,10,0,0,0,0,0.885,-4.1,3.7
ENSMUSG00000021488,NSD1,nuclear receptor binding SET domain protein 1,nucleus|chromosome|,"negative regulation of transcription from RNA polymerase II promoter|gastrulation with mouth forming second|transcription, DNA-templated|histone H3-K36 methylation|histone H3-K36 methylation|histone methylation|histone H4-K20 methylation|positive regulation of transcription, DNA-templated|",chromatin binding|transcription cofactor activity|transcription corepressor activity|zinc ion binding|estrogen receptor binding|histone methyltransferase activity (H4-K20 specific)|retinoic acid receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H3-K36 specific)|androgen receptor binding|,10,0,0,10,0.3,0.0726,0,0,0.885,-2,4.5
ENSMUSG00000021257,ANGEL1,angel homolog 1 (Drosophila),None,None,None,10,0,0,10,-0.3,0.126,0,0,0.885,-9.6,6.2
ENSMUSG00000058756,THRA,"thyroid hormone receptor, alpha",nucleus|nucleoplasm|cytosol|,"cartilage condensation|ossification|regulation of thyroid hormone mediated signaling pathway|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|learning or memory|regulation of heart contraction|female courtship behavior|response to cold|hormone-mediated signaling pathway|gene expression|positive regulation of myotube differentiation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|erythrocyte differentiation|intracellular receptor signaling pathway|thyroid gland development|regulation of myeloid cell apoptotic process|cytoplasmic sequestering of transcription factor|steroid hormone mediated signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription from RNA polymerase II promoter|regulation of lipid catabolic process|Type I pneumocyte differentiation|negative regulation of DNA-templated transcription, initiation|",steroid receptor RNA activator RNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|protein binding|transcription factor binding|zinc ion binding|TBP-class protein binding|protein domain specific binding|chromatin DNA binding|protein complex binding|sequence-specific DNA binding|transcription regulatory region DNA binding|thyroid hormone binding|thyroid hormone binding|,10,0,0,10,-0.2,0.0398,0,0,0.885,-4.2,2.2
ENSMUSG00000033059,PYGB,"phosphorylase, glycogen; brain",cytoplasm|membrane|,carbohydrate metabolic process|glycogen catabolic process|glycogen catabolic process|glucose metabolic process|small molecule metabolic process|,glycogen phosphorylase activity|pyridoxal phosphate binding|,10,0,0,10,0.5,0.232,0,0,0.885,-8.7,3
ENSMUSG00000018697,AATF,apoptosis antagonizing transcription factor,nucleus|nucleolus|cytoplasm|Golgi apparatus|centrosome|focal adhesion|,cellular response to DNA damage stimulus|cell adhesion|regulation of mitotic cell cycle|negative regulation of superoxide anion generation|embryonic cleavage|ribosome biogenesis|negative regulation of amyloid precursor protein biosynthetic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|apoptotic signaling pathway|negative regulation of reactive oxygen species metabolic process|,sequence-specific DNA binding transcription factor activity|protein binding|leucine zipper domain binding|poly(A) RNA binding|tau protein binding|,8,3.9,1.1,9,0.2,0.0461,0,0,0.885,-3.2,8.5
ENSMUSG00000029167,PPARGC1A,"peroxisome proliferator-activated receptor gamma, coactivator 1 alpha","nucleus|nucleus|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|cytosol|PML body|","temperature homeostasis|cellular glucose homeostasis|galactose metabolic process|gluconeogenesis|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|mRNA processing|protein complex assembly|mitochondrion organization|digestion|androgen metabolic process|RNA splicing|response to cold|positive regulation of mitochondrion organization|regulation of cell death|response to muscle activity|fatty acid oxidation|respiratory electron transport chain|androgen receptor signaling pathway|circadian regulation of gene expression|cellular response to oxidative stress|positive regulation of histone acetylation|response to statin|response to starvation|regulation of circadian rhythm|response to leucine|negative regulation of neuron apoptotic process|cellular respiration|positive regulation of gluconeogenesis|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid oxidation|positive regulation of smooth muscle cell proliferation|protein stabilization|brown fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|flavone metabolic process|neuron death|cellular response to nitrite|cellular response to tumor necrosis factor|cellular response to fatty acid|cellular response to hypoxia|response to epinephrine|response to norepinephrine|cellular response to thyroid hormone stimulus|positive regulation of cellular respiration|positive regulation of mitochondrial DNA metabolic process|positive regulation of muscle tissue development|negative regulation of receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|positive regulation of energy homeostasis|positive regulation of ATP biosynthetic process|",nucleotide binding|RNA polymerase II transcription cofactor activity|DNA binding|DNA binding|transcription coactivator activity|RNA binding|protein binding|transcription factor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|chromatin DNA binding|sequence-specific DNA binding|androgen receptor binding|,10,0,0,10,0.1,0.00773,0,0,0.885,-3.8,4.2
ENSMUSG00000031158,TIMM17B,translocase of inner mitochondrial membrane 17 homolog B (yeast),mitochondrial inner membrane presequence translocase complex|integral component of mitochondrial inner membrane|,protein targeting to mitochondrion|cellular protein metabolic process|protein transmembrane transport|,P-P-bond-hydrolysis-driven protein transmembrane transporter activity|,10,0,0,10,0.1,0.017,0,0,0.885,-2.9,2.8
ENSMUSG00000036816,ATOH7,atonal homolog 7 (Drosophila),nucleus|,"neural retina development|transcription, DNA-templated|regulation of transcription, DNA-templated|circadian rhythm|entrainment of circadian clock|optic nerve development|cell differentiation|",DNA binding|protein dimerization activity|,10,0,0,10,0,0,0,0,0.885,-8.2,2
ENSMUSG00000026923,NOTCH1,notch 1,Golgi membrane|MAML1-RBP-Jkappa- ICN1 complex|extracellular region|nucleus|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|cell surface|integral component of membrane|receptor complex|,"negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|cell fate specification|epithelial to mesenchymal transition|liver development|heart looping|sprouting angiogenesis|inflammatory response to antigenic stimulus|endocardium development|endocardium morphogenesis|atrioventricular node development|coronary vein morphogenesis|aortic valve morphogenesis|atrioventricular valve morphogenesis|pulmonary valve morphogenesis|mitral valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac chamber formation|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|cardiac right atrium morphogenesis|cardiac left ventricle morphogenesis|cardiac right ventricle formation|ventricular trabecula myocardium morphogenesis|growth involved in heart morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation|cell migration involved in endocardial cushion formation|pericardium morphogenesis|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|immune response|humoral immune response|Notch signaling pathway|Notch signaling pathway|Notch receptor processing|positive regulation of transcription of Notch receptor target|determination of left/right symmetry|compartment pattern specification|axonogenesis|foregut morphogenesis|endoderm development|heart development|positive regulation of cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|auditory receptor cell fate commitment|glial cell differentiation|gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|negative regulation of myotube differentiation|mesenchymal cell development|regulation of somitogenesis|neural tube development|keratinocyte differentiation|negative regulation of ossification|lung development|positive regulation of cell migration|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|hair follicle morphogenesis|response to muramyl dipeptide|embryonic hindlimb morphogenesis|tube formation|skeletal muscle cell differentiation|cellular response to vascular endothelial growth factor stimulus|anagen|positive regulation of apoptotic process|negative regulation of catalytic activity|positive regulation of keratinocyte differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of calcium ion-dependent exocytosis|positive regulation of JAK-STAT cascade|negative regulation of photoreceptor cell differentiation|somatic stem cell division|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|branching morphogenesis of an epithelial tube|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|negative regulation of glial cell proliferation|cilium morphogenesis|cardiac epithelial to mesenchymal transition|cardiac septum morphogenesis|ventricular septum morphogenesis|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|prostate gland epithelium morphogenesis|regulation of epithelial cell proliferation involved in prostate gland development|arterial endothelial cell differentiation|venous endothelial cell differentiation|cardiac vascular smooth muscle cell development|endocardial cell differentiation|vasculogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|Notch signaling involved in heart development|heart trabecula morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|left/right axis specification|cellular response to follicle-stimulating hormone stimulus|distal tubule development|collecting duct development|glomerular mesangial cell development|interleukin-4 secretion|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of canonical Wnt signaling pathway|neuronal stem cell maintenance|regulation of extracellular matrix assembly|apoptotic process involved in embryonic digit morphogenesis|negative regulation of stem cell differentiation|negative regulation of anoikis|negative regulation of pro-B cell differentiation|negative regulation of endothelial cell chemotaxis|",core promoter binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|enzyme inhibitor activity|receptor activity|calcium ion binding|protein binding|enzyme binding|chromatin DNA binding|sequence-specific DNA binding|,10,0,0,10,0,0,0,0,0.885,-1.9,1.5
ENSMUSG00000025533,ASL,argininosuccinate lyase,cytoplasm|cytosol|extracellular vesicular exosome|,urea cycle|urea cycle|internal protein amino acid acetylation|arginine catabolic process|cellular nitrogen compound metabolic process|arginine biosynthetic process via ornithine|small molecule metabolic process|,argininosuccinate lyase activity|,10,-0.3,0.0245,10,0.4,0.15,0,0,0.885,-2.6,2.3
ENSMUSG00000038607,GNG10,"guanine nucleotide binding protein (G protein), gamma 10",heterotrimeric G-protein complex|plasma membrane|extracellular vesicular exosome|,energy reserve metabolic process|GTP catabolic process|signal transduction|G-protein coupled receptor signaling pathway|synaptic transmission|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|,9,0,0,9,0,0,0,0,0.885,-5.1,2
ENSMUSG00000018752,BC096441,N/A,None,None,None,10,0,0,10,0.8,0.317,0,0,0.885,-5.3,4.1
ENSMUSG00000028309,RNF20,"ring finger protein 20, E3 ubiquitin protein ligase",ubiquitin ligase complex|nucleus|nucleolus|HULC complex|,"protein polyubiquitination|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|histone monoubiquitination|negative regulation of cell migration|positive regulation of histone methylation|histone H2B ubiquitination|positive regulation of transcription, DNA-templated|",p53 binding|chromatin binding|transcription coactivator activity|ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|zinc ion binding|ligase activity|ubiquitin protein ligase binding|histone binding|,9,0.8,0.257,10,0,0,0,0,0.885,-3.2,4.1
ENSMUSG00000038023,ATP6V0A2,"ATPase, H+ transporting, lysosomal V0 subunit a2","vacuolar proton-transporting V-type ATPase, V0 domain|acrosomal vesicle|cytoplasm|lysosomal membrane|plasma membrane|endosome membrane|integral component of membrane|phagocytic vesicle membrane|",cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|,protein binding|hydrogen ion transmembrane transporter activity|,10,0,0,10,-0.1,0.00525,0,0,0.885,-4,3.1
ENSMUSG00000042903,FOXO4,forkhead box O4,nucleus|nucleus|nucleoplasm|cytoplasm|cytosol|cytosol|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cell cycle arrest|mitotic G2 DNA damage checkpoint|epidermal growth factor receptor signaling pathway|muscle organ development|negative regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|negative regulation of angiogenesis|Fc-epsilon receptor signaling pathway|innate immune response|positive regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|stem cell differentiation|negative regulation of smooth muscle cell differentiation|negative regulation of G0 to G1 transition|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|enzyme binding|sequence-specific DNA binding|,10,-0.5,0.148,10,0,0,0,0,0.885,-7.2,3.9
ENSMUSG00000035401,2210018M11RIK,RIKEN cDNA 2210018M11 gene,nucleus|,"DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|chromatin modification|",protein binding|protein homodimerization activity|,10,-1.2,0.000542,10,0.6,0.116,0,0,0.885,-3.4,2.3
ENSMUSG00000024190,DUSP1,dual specificity phosphatase 1,nucleus|cytoplasm|,inactivation of MAPK activity|endoderm formation|protein dephosphorylation|response to oxidative stress|response to light stimulus|response to estradiol|response to retinoic acid|cellular response to hormone stimulus|response to testosterone|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|peptidyl-threonine dephosphorylation|response to hydrogen peroxide|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|response to glucocorticoid|negative regulation of meiotic cell cycle|response to cAMP|response to calcium ion|mitotic cell cycle arrest|regulation of mitotic cell cycle spindle assembly checkpoint|,non-membrane spanning protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|,10,-0.1,0.00884,10,0,0,0,0,0.885,-2.8,2
ENSMUSG00000028032,PAPSS1,3'-phosphoadenosine 5'-phosphosulfate synthase 1,cytosol|,sulfate assimilation|skeletal system development|carbohydrate metabolic process|xenobiotic metabolic process|phosphorylation|glycosaminoglycan metabolic process|small molecule metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|,adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|nucleotidyltransferase activity|,10,0,0,10,0.6,0.368,0,0,0.885,-2.2,6.6
ENSMUSG00000030246,LDHB,lactate dehydrogenase B,cytoplasm|cytoplasm|mitochondrion|cytosol|membrane|extracellular vesicular exosome|,lactate metabolic process|pyruvate metabolic process|glycolytic process|NAD metabolic process|cellular metabolic process|cellular carbohydrate metabolic process|small molecule metabolic process|oxidation-reduction process|,L-lactate dehydrogenase activity|protein binding|kinase binding|identical protein binding|NAD binding|,10,0,0,10,0,0,0,0,0.885,-2.8,2
ENSMUSG00000000125,WNT3,"wingless-type MMTV integration site family, member 3",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|,cell morphogenesis|mesoderm formation|axon guidance|anterior/posterior axis specification|dorsal/ventral axis specification|positive regulation of gene expression|neuron differentiation|neuron differentiation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|cell fate commitment|positive regulation of collateral sprouting in absence of injury|negative regulation of axon extension involved in axon guidance|Spemann organizer formation at the anterior end of the primitive streak|canonical Wnt signaling pathway|limb bud formation|head morphogenesis|mammary gland epithelium development|cellular response to retinoic acid|,frizzled binding|protein binding|protein domain specific binding|receptor agonist activity|,10,0,0,10,-0.5,0.486,0,0,0.885,-5.1,4.5
ENSMUSG00000054766,SET,SET nuclear proto-oncogene,nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|protein complex|perinuclear region of cytoplasm|,"mitotic cell cycle|DNA replication|nucleosome assembly|nucleosome disassembly|nucleocytoplasmic transport|gene expression|RNA metabolic process|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|negative regulation of transcription, DNA-templated|regulation of catalytic activity|",DNA binding|protein phosphatase inhibitor activity|protein binding|protein phosphatase type 2A regulator activity|histone binding|,9,-1.2,1.19,9,0,0,0,0,0.885,-5.5,2.5
ENSMUSG00000021188,TRIP11,thyroid hormone receptor interactor 11,nucleus|Golgi apparatus|cytoskeleton|membrane|,protein targeting to Golgi|ventricular septum development|transcription from RNA polymerase II promoter|regulation of RNA biosynthetic process|,transcription coactivator activity|protein binding|,9,0.1,0.000856,10,0,0,0,0,0.885,-2.7,3.8
ENSMUSG00000021823,VCL,vinculin,extracellular region|cytosol|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|cell-cell adherens junction|fascia adherens|focal adhesion|focal adhesion|actin cytoskeleton|cell-substrate junction|costamere|costamere|protein complex|extracellular vesicular exosome|,morphogenesis of an epithelium|platelet degranulation|cellular component movement|muscle contraction|cell adhesion|cell-matrix adhesion|blood coagulation|lamellipodium assembly|platelet activation|negative regulation of cell migration|adherens junction assembly|protein localization to cell surface|apical junction assembly|epithelial cell-cell adhesion|,dystroglycan binding|actin binding|structural molecule activity|protein binding|beta-catenin binding|alpha-catenin binding|cadherin binding|,10,-3.4,2.02,10,0.5,0.31,0,0,0.885,-8.6,2
ENSMUSG00000030693,KLK10,kallikrein-related peptidase 10,extracellular region|,proteolysis|cell cycle|,serine-type endopeptidase activity|serine-type peptidase activity|,10,-2.8,0.41,10,0,0,0,0,0.885,-8.2,2
ENSMUSG00000050424,PNMA5,paraneoplastic Ma antigen family member 5,None,positive regulation of apoptotic process|,None,10,0,0,10,-2.1,1.5,0,0,0.885,-6.8,4
ENSMUSG00000044986,TST,thiosulfate sulfurtransferase (rhodanese),extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|extracellular vesicular exosome|,"sulfur amino acid metabolic process|sulfur amino acid catabolic process|cyanate catabolic process|epithelial cell differentiation|cellular nitrogen compound metabolic process|rRNA import into mitochondrion|small molecule metabolic process|rRNA transport|sulfide oxidation, using sulfide:quinone oxidoreductase|",thiosulfate sulfurtransferase activity|5S rRNA binding|,10,0,0,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000044477,ZFAND3,"zinc finger, AN1-type domain 3",None,None,DNA binding|zinc ion binding|,10,0,0,10,-0.2,0.0211,0,0,0.885,-3,1.9
ENSMUSG00000024421,LAMA3,"laminin, alpha 3",extracellular region|basement membrane|laminin-1 complex|laminin-5 complex|,cell adhesion|epidermis development|extracellular matrix disassembly|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|hemidesmosome assembly|cell junction assembly|regulation of embryonic development|,receptor binding|structural molecule activity|,10,0.9,0.254,10,0,0,0,0,0.885,-3.3,4.8
ENSMUSG00000022429,DMC1,DNA meiotic recombinase 1,"chromosome, telomeric region|condensed nuclear chromosome|nucleus|chromosome|",ovarian follicle development|oocyte maturation|ATP catabolic process|meiotic nuclear division|synapsis|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|female gamete generation|,DNA binding|protein binding|ATP binding|DNA-dependent ATPase activity|,10,0,0,10,0,0,0,0,0.885,-3.5,2
ENSMUSG00000029397,RCHY1,"ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase",ubiquitin ligase complex|nucleus|cytoplasm|nuclear speck|,protein ubiquitination|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein autoubiquitination|,p53 binding|ubiquitin-protein transferase activity|receptor binding|protein binding|zinc ion binding|ligase activity|protein homodimerization activity|,10,0,0,10,0.2,0.0221,0,0,0.885,-4.3,6
ENSMUSG00000091898,TNNC1,troponin C type 1 (slow),nucleus|mitochondrion|cytosol|troponin complex|actin cytoskeleton|,diaphragm contraction|regulation of muscle contraction|regulation of muscle contraction|response to metal ion|muscle filament sliding|regulation of muscle filament sliding speed|regulation of ATPase activity|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|,calcium ion binding|protein binding|troponin I binding|troponin I binding|troponin T binding|protein homodimerization activity|calcium-dependent protein binding|actin filament binding|,10,0,0,10,0.1,0.00881,0,0,0.885,-3.2,3.3
ENSMUSG00000041132,N4BP2L1,NEDD4 binding protein 2-like 1,None,None,None,10,0,0,10,-0.9,0.537,0,0,0.885,-4.7,3.2
ENSMUSG00000022863,BTG3,"BTG family, member 3",cytoplasm|,negative regulation of cell proliferation|negative regulation of mitotic cell cycle|,protein binding|,9,0,0,9,-2,0.489,0,0,0.885,-6.7,2.4
ENSMUSG00000042333,TNFRSF14,"tumor necrosis factor receptor superfamily, member 14",plasma membrane|integral component of plasma membrane|external side of plasma membrane|,positive regulation of cytokine secretion involved in immune response|immune response|cell surface receptor signaling pathway|response to virus|viral process|T cell costimulation|tumor necrosis factor-mediated signaling pathway|negative regulation of alpha-beta T cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of T cell migration|,virus receptor activity|tumor necrosis factor-activated receptor activity|protein binding|ubiquitin protein ligase binding|,10,0,0,10,0,0,0,0,0.885,-2,2
ENSMUSG00000006134,CRKL,v-crk avian sarcoma virus CT10 oncogene homolog-like,endosome|cytosol|extracellular vesicular exosome|,activation of MAPKK activity|blood vessel development|JNK cascade|Ras protein signal transduction|heart development|organ morphogenesis|anterior/posterior pattern specification|positive regulation of signal transduction|intracellular signal transduction|neurotrophin TRK receptor signaling pathway|thymus development|parathyroid gland development|,signal transducer activity|SH3/SH2 adaptor activity|protein binding|poly(A) RNA binding|,10,0,0,9,-0.6,0.328,0,0,0.885,-4,2.5
ENSMUSG00000033751,GADD45GIP1,"growth arrest and DNA-damage-inducible, gamma interacting protein 1",nucleus|mitochondrion|,cell cycle|viral process|,protein binding|,10,-0.1,0.00807,10,0.2,0.065,0,0,0.885,-6.4,3
ENSMUSG00000064302,CLASP1,cytoplasmic linker associated protein 1,kinetochore|condensed chromosome kinetochore|Golgi apparatus|centrosome|kinetochore microtubule|cytosol|spindle microtubule|cytoplasmic microtubule|cell cortex|membrane|cortical microtubule cytoskeleton|centrosomal corona|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|microtubule bundle formation|microtubule nucleation|negative regulation of microtubule depolymerization|negative regulation of microtubule depolymerization|establishment or maintenance of cell polarity|axon guidance|exit from mitosis|microtubule organizing center organization|negative regulation of microtubule polymerization or depolymerization|microtubule anchoring|establishment of spindle orientation|establishment of spindle orientation|establishment of spindle orientation|cell division|,protein binding|microtubule binding|microtubule binding|kinetochore binding|microtubule plus-end binding|,10,0,0,10,0,0,0,0,0.885,-6.7,2
ENSMUSG00000002416,NDUFB2,"NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa",mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I|,"mitochondrial electron transport, NADH to ubiquinone|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|",NADH dehydrogenase (ubiquinone) activity|,10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000020680,TAF15,"TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa",nucleus|cytoplasm|,"positive regulation of transcription, DNA-templated|",nucleotide binding|DNA binding|protein binding|zinc ion binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-7.3,3
ENSMUSG00000040459,ARGLU1,arginine and glutamate rich 1,nucleus|mitochondrion|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",protein binding|,10,0,0,10,-0.2,0.0103,0,0,0.885,-8.7,8.8
ENSMUSG00000019794,KATNA1,katanin p60 (ATPase containing) subunit A 1,spindle pole|nucleus|cytoplasm|lipid particle|centrosome|spindle|microtubule|plasma membrane|axon|growth cone|midbody|neuronal cell body|,microtubule bundle formation|neuron migration|ATP catabolic process|mitotic nuclear division|protein localization|negative regulation of neuron projection development|cytoplasmic microtubule organization|microtubule severing|mitotic interphase|,protein binding|ATP binding|microtubule binding|microtubule-severing ATPase activity|dynein binding|protein heterodimerization activity|,10,0,0,10,-0.1,0.0129,0,0,0.885,-7.4,2
ENSMUSG00000024962,VEGFB,vascular endothelial growth factor B,extracellular region|extracellular space|membrane|platelet alpha granule lumen|,angiogenesis|positive regulation of endothelial cell proliferation|platelet degranulation|protein O-linked glycosylation|blood coagulation|negative regulation of gene expression|platelet activation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|response to drug|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|cardiac muscle contraction|positive regulation of mast cell chemotaxis|coronary vasculature development|positive regulation of ERK1 and ERK2 cascade|,protein binding|growth factor activity|heparin binding|chemoattractant activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|protein heterodimerization activity|,10,-0.8,0.466,10,0,0,0,0,0.885,-4.7,2.5
ENSMUSG00000041429,NTHL1,nth endonuclease III-like 1 (E. coli),nucleus|nucleoplasm|mitochondrion|,"DNA catabolic process, endonucleolytic|DNA catabolic process, endonucleolytic|DNA repair|base-excision repair|base-excision repair, AP site formation|base-excision repair, AP site formation|nucleotide-excision repair, DNA incision, 5'-to lesion|depyrimidination|","double-stranded DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|protein binding|DNA N-glycosylase activity|metal ion binding|4 iron, 4 sulfur cluster binding|",10,-0.4,0.189,10,0,0,0,0,0.885,-3.1,1.8
ENSMUSG00000027552,E2F5,"E2F transcription factor 5, p130-binding",nucleoplasm|transcription factor complex|cytoplasm|,"mitotic cell cycle|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway|organ morphogenesis|gene expression|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle|",DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|,10,0.3,0.0569,10,0,0,0,0,0.885,-3,2.5
ENSMUSG00000021379,ID4,"inhibitor of DNA binding 4, dominant negative helix-loop-helix protein",nucleus|cytoplasm|,"G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|neuroblast proliferation|positive regulation of cell proliferation|hippocampus development|cerebral cortex neuron differentiation|central nervous system myelination|cellular protein localization|fat cell differentiation|negative regulation of fat cell differentiation|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|",RNA polymerase II transcription factor binding|transcription corepressor activity|protein binding|protein dimerization activity|,10,0,0,10,0.5,0.3,0,0,0.885,-2,2.1
ENSMUSG00000009350,MPO,myeloperoxidase,extracellular space|nucleus|mitochondrion|lysosome|secretory granule|azurophil granule|extracellular vesicular exosome|,response to yeast|hypochlorous acid biosynthetic process|respiratory burst involved in defense response|defense response|response to oxidative stress|aging|response to mechanical stimulus|removal of superoxide radicals|response to food|response to lipopolysaccharide|low-density lipoprotein particle remodeling|hydrogen peroxide catabolic process|negative regulation of apoptotic process|negative regulation of growth of symbiont in host|defense response to fungus|oxidation-reduction process|,chromatin binding|peroxidase activity|heparin binding|heme binding|metal ion binding|,8,-0.1,0.0135,8,3.1,1.78,0,0,0.885,-2.9,7.6
ENSMUSG00000021253,TGFB3,"transforming growth factor, beta 3",extracellular region|extracellular space|nucleus|plasma membrane|cell surface|T-tubule|extracellular matrix|platelet alpha granule lumen|neuronal cell body|,"activation of MAPK activity|response to hypoxia|in utero embryonic development|platelet degranulation|transforming growth factor beta receptor signaling pathway|SMAD protein import into nucleus|salivary gland morphogenesis|female pregnancy|aging|blood coagulation|negative regulation of DNA replication|negative regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|cell growth|menstrual cycle phase|platelet activation|extracellular matrix organization|positive regulation of bone mineralization|negative regulation of transforming growth factor beta receptor signaling pathway|mammary gland development|response to progesterone|positive regulation of collagen biosynthetic process|response to laminar fluid shear stress|odontogenesis|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|response to estrogen|ossification involved in bone remodeling|cell-cell junction organization|positive regulation of DNA replication|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|lung alveolus development|digestive tract development|embryonic neurocranium morphogenesis|inner ear development|positive regulation of protein secretion|positive regulation of filopodium assembly|positive regulation of cell division|palate development|face morphogenesis|frontal suture morphogenesis|positive regulation of SMAD protein import into nucleus|detection of hypoxia|",type II transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding|protein binding|protein binding|growth factor activity|type I transforming growth factor beta receptor binding|identical protein binding|protein heterodimerization activity|transforming growth factor beta binding|,10,0,0,10,0.2,0.0309,0,0,0.885,-7,6
ENSMUSG00000002108,NR1H3,"nuclear receptor subfamily 1, group H, member 3",nuclear chromatin|nucleus|nucleoplasm|,"negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|gene expression|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of receptor biosynthetic process|positive regulation of cholesterol efflux|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|intracellular receptor signaling pathway|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|response to progesterone|positive regulation of toll-like receptor 4 signaling pathway|cholesterol homeostasis|regulation of circadian rhythm|negative regulation of macrophage activation|apoptotic cell clearance|steroid hormone mediated signaling pathway|cellular lipid metabolic process|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|negative regulation of pinocytosis|negative regulation of inflammatory response|positive regulation of lipoprotein lipase activity|lipid homeostasis|sterol homeostasis|negative regulation of interferon-gamma-mediated signaling pathway|triglyceride homeostasis|cellular response to lipopolysaccharide|negative regulation of pancreatic juice secretion|negative regulation of secretion of lysosomal enzymes|regulation of cholesterol homeostasis|positive regulation of cholesterol homeostasis|",DNA binding|steroid hormone receptor activity|transcription coactivator activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|protein binding|zinc ion binding|cholesterol binding|sterol response element binding|sequence-specific DNA binding|transcription regulatory region DNA binding|transcription regulatory region DNA binding|,10,0.2,0.0625,10,0,0,0,0,0.885,-2.7,3
ENSMUSG00000055694,GDF1,growth differentiation factor 1,extracellular space|,growth|,cytokine activity|growth factor activity|,10,-0.7,0.189,10,0,0,0,0,0.885,-7.3,3.8
ENSMUSG00000024790,SAC3D1,SAC3 domain containing 1,nucleus|cytoplasm|centrosome|spindle|,mitotic nuclear division|negative regulation of JAK-STAT cascade|regulation of immune response|spindle assembly|centrosome duplication|,protein binding|,10,0,0,10,0,0,0,0,0.885,-6.1,2.8
ENSMUSG00000031502,COL4A1,"collagen, type IV, alpha 1",extracellular region|extracellular region|collagen type IV trimer|basement membrane|endoplasmic reticulum lumen|extracellular matrix|,patterning of blood vessels|axon guidance|brain development|neuromuscular junction development|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|epithelial cell differentiation|blood vessel morphogenesis|retinal blood vessel morphogenesis|renal tubule morphogenesis|cellular response to amino acid stimulus|basement membrane organization|,extracellular matrix structural constituent|protein binding|extracellular matrix constituent conferring elasticity|platelet-derived growth factor binding|,10,0,0,10,0,0,0,0,0.885,-2,2
ENSMUSG00000008348,UBC,ubiquitin C,nucleoplasm|cytosol|plasma membrane|endosome membrane|endocytic vesicle membrane|,"G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|protein polyubiquitination|mitotic cell cycle|toll-like receptor signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|carbohydrate metabolic process|glycogen biosynthetic process|glucose metabolic process|DNA repair|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|Notch receptor processing|I-kappaB kinase/NF-kappaB signaling|JNK cascade|fibroblast growth factor receptor signaling pathway|gene expression|viral process|RNA metabolic process|mRNA metabolic process|endosomal transport|viral life cycle|virion assembly|viral protein processing|cytokine-mediated signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|ion transmembrane transport|TRIF-dependent toll-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|small molecule metabolic process|innate immune response|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to hypoxia|intracellular transport of virus|apoptotic signaling pathway|",protease binding|protein binding|poly(A) RNA binding|,10,0,0,10,-0.2,0.0272,0,0,0.885,-7.7,4
ENSMUSG00000045322,TLR9,toll-like receptor 9,Golgi membrane|extracellular region|cytoplasm|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|endosome membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|early phagosome|endolysosome membrane|,toll-like receptor signaling pathway|response to molecule of bacterial origin|MyD88-dependent toll-like receptor signaling pathway|inflammatory response|I-kappaB phosphorylation|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|positive regulation of toll-like receptor signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of NF-kappaB import into nucleus|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JUN kinase activity|positive regulation of interferon-gamma biosynthetic process|innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|regulation of cytokine secretion|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|,transmembrane signaling receptor activity|interleukin-1 receptor binding|siRNA binding|,10,0,0,10,0,0,0,0,0.885,-7.7,2
ENSMUSG00000019302,ATP6V0A1,"ATPase, H+ transporting, lysosomal V0 subunit a1","vacuolar proton-transporting V-type ATPase, V0 domain|nucleus|cytoplasm|Golgi apparatus|plasma membrane|endosome membrane|integral component of membrane|phagocytic vesicle membrane|melanosome|intracellular membrane-bounded organelle|extracellular vesicular exosome|",cellular iron ion homeostasis|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|transferrin transport|interaction with host|transmembrane transport|phagosome maturation|,protein binding|hydrogen ion transmembrane transporter activity|ATPase binding|,10,0,0,10,0,0,0,0,0.885,-2,1.3
ENSMUSG00000028364,TNC,tenascin C,extracellular region|basement membrane|interstitial matrix|extracellular space|membrane|extracellular matrix|extracellular matrix|,osteoblast differentiation|cell adhesion|negative regulation of cell adhesion|neuromuscular junction development|positive regulation of cell proliferation|response to wounding|response to mechanical stimulus|positive regulation of gene expression|peripheral nervous system axon regeneration|extracellular matrix organization|wound healing|odontogenesis of dentin-containing tooth|response to ethanol|bud outgrowth involved in lung branching|mesenchymal-epithelial cell signaling involved in prostate gland development|prostate gland epithelium morphogenesis|cellular response to retinoic acid|cellular response to vitamin D|response to fibroblast growth factor|cellular response to prostaglandin D stimulus|,syndecan binding|,10,0,0,10,0,0,0,0,0.885,-3.5,2.8
ENSMUSG00000030059,TMF1,TATA element modulatory factor 1,Golgi membrane|nucleus|endoplasmic reticulum|Golgi apparatus|,"acrosome assembly|positive regulation of cytokine production|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|spermatid nucleus differentiation|negative regulation of gene expression|sperm motility|luteinizing hormone secretion|Leydig cell differentiation|defense response to bacterium|negative regulation of apoptotic process|regulation of proteasomal protein catabolic process|cellular response to organic cyclic compound|positive regulation of testosterone secretion|",DNA binding|transcription cofactor activity|protein binding|,9,0.2,0.0347,10,0,0,0,0,0.885,-2.6,3.2
ENSMUSG00000063382,BCL9L,B-cell CLL/lymphoma 9-like,nucleus|nucleus|,"transcription, DNA-templated|positive regulation of epithelial to mesenchymal transition|regulation of cell morphogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell maintenance|skeletal muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|",transcription coactivator activity|beta-catenin binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000003477,INMT,indolethylamine N-methyltransferase,cytosol|,amine metabolic process|response to toxic substance|methylation|,thioether S-methyltransferase activity|amine N-methyltransferase activity|,10,0,0,10,0,0,0,0,0.885,-4,3.2
ENSMUSG00000033857,ENGASE,endo-beta-N-acetylglucosaminidase,cytosol|,metabolic process|,mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity|,9,0,0,10,0,0,0,0,0.885,-2.7,1.5
ENSMUSG00000021694,ERCC8,excision repair cross-complementation group 8,nucleotide-excision repair complex|nucleus|nucleoplasm|nuclear matrix|Cul4A-RING E3 ubiquitin ligase complex|protein complex|,protein polyubiquitination|DNA repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair|cellular response to DNA damage stimulus|response to oxidative stress|response to oxidative stress|response to UV|response to UV|response to X-ray|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA repair|protein autoubiquitination|,ubiquitin-protein transferase activity|protein binding|protein complex binding|,10,0.6,0.397,10,-1.9,0.926,0,0,0.885,-6.4,5.4
ENSMUSG00000015342,XK,X-linked Kx blood group,integral component of membrane|,transport|amino acid transport|,transporter activity|protein binding|,10,0.4,0.233,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000034959,5031414D18RIK,RIKEN cDNA 5031414D18 gene,cellular_component|,biological_process|,molecular_function|,10,-0.2,0.0233,10,0,0,0,0,0.885,-2.8,2
ENSMUSG00000022051,BNIP3L,BCL2/adenovirus E1B 19kDa interacting protein 3-like,nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|integral component of membrane|intrinsic component of membrane|,viral process|mitochondrial protein catabolic process|positive regulation of apoptotic process|negative regulation of apoptotic process|defense response to virus|mitochondrial outer membrane permeabilization|,protein binding|lamin binding|lamin binding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|,10,0.6,0.0285,10,0,0,0,0,0.885,-3.9,4.6
ENSMUSG00000055125,M5C1000I18RIK,RIKEN cDNA M5C1000I18 gene,cellular_component|,biological_process|,molecular_function|,6,0,0,6,0,0,0,0,0.885,-1.7,1.9
ENSMUSG00000002228,PPM1J,"protein phosphatase, Mg2+/Mn2+ dependent, 1J",None,protein dephosphorylation|,protein serine/threonine phosphatase activity|,10,0,0,10,0,0,0,0,0.885,-2.4,3.3
ENSMUSG00000027776,IL12A,interleukin 12A,extracellular space|cytoplasm|interleukin-12 complex|interleukin-12 complex|,positive regulation of T cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|immune response|cell cycle arrest|response to virus|response to UV-B|cell migration|response to lipopolysaccharide|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of mononuclear cell proliferation|positive regulation of smooth muscle cell apoptotic process|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat4 protein|defense response to protozoan|positive regulation of T cell differentiation|positive regulation of cell adhesion|positive regulation of natural killer cell mediated cytotoxicity|negative regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|defense response to Gram-positive bacterium|positive regulation of NK T cell activation|extrinsic apoptotic signaling pathway|,cytokine activity|cytokine activity|interleukin-12 receptor binding|protein binding|growth factor activity|growth factor activity|interleukin-12 beta subunit binding|interleukin-27 binding|protein heterodimerization activity|,10,-1,0.475,10,0,0,0,0,0.885,-3.6,2.6
ENSMUSG00000030483,CYP2B10,"cytochrome P450, family 2, subfamily b, polypeptide 10",endoplasmic reticulum|membrane|intracellular membrane-bounded organelle|,xenobiotic metabolic process|steroid metabolic process|drug metabolic process|cellular ketone metabolic process|exogenous drug catabolic process|oxidation-reduction process|,"monooxygenase activity|iron ion binding|steroid hydroxylase activity|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|metal ion binding|aromatase activity|",10,0,0,10,0.1,0.0301,0,0,0.885,-6.8,2
ENSMUSG00000035678,TNFSF9,"tumor necrosis factor (ligand) superfamily, member 9",extracellular space|plasma membrane|integral component of membrane|,apoptotic process|immune response|signal transduction|cell-cell signaling|cell proliferation|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of activated T cell proliferation|myeloid dendritic cell differentiation|positive regulation of cytotoxic T cell differentiation|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|,9,0,0,10,0,0,0,0,0.885,-6.4,3.5
ENSMUSG00000031520,VEGFC,vascular endothelial growth factor C,extracellular region|extracellular space|membrane|platelet alpha granule lumen|,angiogenesis|positive regulation of neuroblast proliferation|platelet degranulation|substrate-dependent cell migration|signal transduction|blood coagulation|positive regulation of cell proliferation|organ morphogenesis|morphogenesis of embryonic epithelium|platelet activation|regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein autophosphorylation|response to drug|positive regulation of blood vessel endothelial cell migration|negative regulation of blood pressure|vascular endothelial growth factor receptor signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of protein secretion|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis|positive regulation of lymphangiogenesis|,protein binding|growth factor activity|chemoattractant activity|vascular endothelial growth factor receptor 3 binding|,10,0,0,10,0,0,0,0,0.885,-2.8,2
ENSMUSG00000005824,TNFSF14,"tumor necrosis factor (ligand) superfamily, member 14",extracellular space|cytoplasm|plasma membrane|integral component of membrane|,apoptotic process|immune response|signal transduction|release of cytoplasmic sequestered NF-kappaB|positive regulation of T cell chemotaxis|T cell costimulation|T cell proliferation|T cell activation|T cell homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to mechanical stimulus|,receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|,10,-0.8,0.434,10,0,0,0,0,0.885,-6.4,3.2
ENSMUSG00000000171,SDHD,"succinate dehydrogenase complex, subunit D, integral membrane protein",mitochondrion|mitochondrial envelope|mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex II|integral component of membrane|,tricarboxylic acid cycle|tricarboxylic acid cycle|tricarboxylic acid cycle|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|,succinate dehydrogenase activity|electron carrier activity|heme binding|metal ion binding|ubiquinone binding|,10,-1.5,0.529,10,0,0,0,0,0.885,-3.8,1.8
ENSMUSG00000025583,RPTOR,"regulatory associated protein of MTOR, complex 1",cytoplasm|lysosome|lysosomal membrane|cytosol|TORC1 complex|,positive regulation of endothelial cell proliferation|cell cycle arrest|insulin receptor signaling pathway|regulation of cell size|cell growth|cellular response to nutrient levels|TOR signaling|positive regulation of TOR signaling|positive regulation of transcription from RNA polymerase III promoter|cellular response to amino acid stimulus|positive regulation of protein serine/threonine kinase activity|,RNA polymerase III type 1 promoter DNA binding|RNA polymerase III type 2 promoter DNA binding|RNA polymerase III type 3 promoter DNA binding|TFIIIC-class transcription factor binding|protein binding|protein kinase binding|protein complex binding|14-3-3 protein binding|,9,1.9,0.554,8,0,0,0,0,0.885,-6.5,7
ENSMUSG00000024642,TLE4,transducin-like enhancer of split 4,nucleus|nucleus|nucleoplasm|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|Notch signaling pathway|biological_process|Wnt signaling pathway|,molecular_function|chromatin binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|transcription corepressor activity|repressing transcription factor binding|,10,-0.2,0.0761,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000092118,FANCF,"Fanconi anemia, complementation group F",nucleoplasm|Fanconi anaemia nuclear complex|,DNA repair|biological_process|,molecular_function|protein binding|,10,0,0,10,0,0,0,0,0.885,-3.1,2.5
ENSMUSG00000009356,LPO,lactoperoxidase,extracellular space|cytoplasm|basolateral plasma membrane|extracellular vesicular exosome|,detection of chemical stimulus involved in sensory perception of bitter taste|response to oxidative stress|thiocyanate metabolic process|defense response to bacterium|hydrogen peroxide catabolic process|oxidation-reduction process|,heme binding|thiocyanate peroxidase activity|metal ion binding|,10,0,0,10,0.8,0.692,0,0,0.885,-6.7,3.5
ENSMUSG00000037369,KDM6A,lysine (K)-specific demethylase 6A,nucleus|histone methyltransferase complex|,in utero embryonic development|neural tube closure|respiratory system process|heart development|somite rostral/caudal axis specification|mesodermal cell differentiation|notochord morphogenesis|histone H3-K4 methylation|oxidation-reduction process|canonical Wnt signaling pathway|histone H3-K27 demethylation|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|metal ion binding|dioxygenase activity|histone demethylase activity (H3-K27 specific)|,9,-1.3,0.209,9,0,0,0,0,0.885,-4.9,3.2
ENSMUSG00000025156,GPS1,G protein pathway suppressor 1,nucleus|cytoplasm|COP9 signalosome|,inactivation of MAPK activity|cell cycle|JNK cascade|cullin deneddylation|,GTPase inhibitor activity|protein binding|,10,-0.2,0.0307,10,0.4,0.172,0,0,0.885,-2,2.8
ENSMUSG00000048264,DIP2C,DIP2 disco-interacting protein 2 homolog C (Drosophila),cellular_component|nucleus|,biological_process|metabolic process|,molecular_function|catalytic activity|transcription factor binding|,10,0,0,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000026389,STEAP3,"STEAP family member 3, metalloreductase",multivesicular body|plasma membrane|endosome membrane|integral component of membrane|,cellular iron ion homeostasis|apoptotic process|cell cycle|protein secretion|protein secretion|transferrin transport|positive regulation of apoptotic process|transmembrane transport|oxidation-reduction process|,ferric-chelate reductase activity|protein binding|metal ion binding|,10,-1,0.176,10,0,0,0,0,0.885,-3.6,2
ENSMUSG00000028255,CLCA3,chloride channel calcium activated 3,extracellular region|microvillus|integral component of membrane|secretory granule|zymogen granule membrane|,transport|ion transport|calcium ion transport|chloride transport|chloride transmembrane transport|,chloride channel activity|,10,3.5,0.719,10,-1.4,0.141,0,0,0.885,-6.2,7.1
ENSMUSG00000022935,GRIK1,"glutamate receptor, ionotropic, kainate 1",plasma membrane|integral component of plasma membrane|cell junction|dendrite|kainate selective glutamate receptor complex|presynaptic membrane|postsynaptic membrane|,"transport|glutamate receptor signaling pathway|synaptic transmission|nervous system development|central nervous system development|positive regulation of gamma-aminobutyric acid secretion|adult behavior|positive regulation of synaptic transmission, GABAergic|ion transmembrane transport|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|behavioral response to pain|regulation of synaptic transmission, glutamatergic|negative regulation of synaptic transmission, glutamatergic|regulation of excitatory postsynaptic membrane potential|regulation of inhibitory postsynaptic membrane potential|",extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|,10,-0.5,0.224,10,0.1,0.012,0,0,0.885,-3.3,3
ENSMUSG00000034926,DHCR24,24-dehydrocholesterol reductase,Golgi membrane|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum membrane|cytosol|cytoskeleton|membrane|integral component of membrane|,cholesterol biosynthetic process|cholesterol biosynthetic process|cholesterol biosynthetic process|cholesterol biosynthetic process|cholesterol biosynthetic process|apoptotic process|response to oxidative stress|cell cycle arrest|Ras protein signal transduction|protein localization|negative regulation of cell proliferation|response to hormone|tissue development|male genitalia development|plasminogen activation|amyloid precursor protein catabolic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skin development|small molecule metabolic process|oxidation-reduction process|regulation of neuron death|,"UDP-N-acetylmuramate dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|enzyme binding|peptide antigen binding|delta24-sterol reductase activity|flavin adenine dinucleotide binding|",10,0,0,10,0,0,0,0,0.885,-3.4,3.8
ENSMUSG00000075053,VDAC3-PS1,"voltage-dependent anion channel 3, pseudogene 1",None,None,None,10,0,0,9,0,0,0,0,0.885,-5.5,3.4
ENSMUSG00000031385,PLXNB3,plexin B3,intracellular|plasma membrane|integral component of membrane|,positive regulation of endothelial cell proliferation|negative regulation of cell adhesion|axon guidance|negative regulation of lamellipodium assembly|negative regulation of cell migration|negative regulation of GTPase activity|positive chemotaxis|cell chemotaxis|semaphorin-plexin signaling pathway|,protein binding|semaphorin receptor activity|protein domain specific binding|,10,0.2,0.0237,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000040254,SEMA3D,"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D",extracellular region|membrane|,nervous system development|cell differentiation|,receptor activity|,10,0,0,10,0.2,0.0238,0,0,0.885,-1.9,2.2
ENSMUSG00000038160,ATG5,autophagy related 5,cytoplasm|autophagic vacuole|axoneme|membrane|pre-autophagosomal structure membrane|,autophagic vacuole assembly|blood vessel remodeling|regulation of cytokine secretion involved in immune response|autophagy|apoptotic process|response to fungus|negative regulation of protein ubiquitination|negative regulation of type I interferon production|vasodilation|response to drug|negative regulation of apoptotic process|post-translational protein modification|innate immune response|otolith development|ventricular cardiac muscle cell development|heart contraction|regulation of cilium assembly|,protein binding|,10,0,0,10,0,0,0,0,0.885,-2.4,1.8
ENSMUSG00000028149,RAP1GDS1,"RAP1, GTP-GDP dissociation stimulator 1",mitochondrion|endoplasmic reticulum|cytosol|extracellular vesicular exosome|,vascular smooth muscle contraction|myosin filament assembly|positive regulation of Rho GTPase activity|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of mitochondrial calcium ion concentration|,GTPase activator activity|,10,-1.7,0.0266,10,-0.6,0.0468,0,0,0.885,-5.8,2.1
ENSMUSG00000028191,BCL10,B-cell CLL/lymphoma 10,immunological synapse|nucleus|cytoplasm|lysosome|cytosol|cytosol|cytoplasmic microtubule|plasma membrane|CBM complex|T cell receptor complex|protein complex|membrane raft|lipopolysaccharide receptor complex|perinuclear region of cytoplasm|,"B cell apoptotic process|neural tube closure|toll-like receptor signaling pathway|response to molecule of bacterial origin|adaptive immune response|negative regulation of mature B cell apoptotic process|cellular defense response|cell death|response to fungus|immunoglobulin mediated immune response|positive regulation of protein ubiquitination|response to food|positive regulation of mast cell cytokine production|Fc-epsilon receptor signaling pathway|lymphotoxin A biosynthetic process|interleukin-6 biosynthetic process|positive regulation of phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|innate immune response|positive regulation of interleukin-8 biosynthetic process|positive regulation of transcription, DNA-templated|T cell receptor signaling pathway|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of T cell activation|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|protein homooligomerization|protein homooligomerization|T cell apoptotic process|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway|",protease binding|transcription coactivator activity|protein binding|protein C-terminus binding|transcription factor binding|kinase activator activity|enzyme binding|kinase binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin binding|protein kinase B binding|protein self-association|NF-kappaB binding|,9,4.8,0.852,9,0,0,0,0,0.885,-4,10.8
ENSMUSG00000079478,SSSCA1,Sjogren syndrome/scleroderma autoantigen 1,None,mitotic nuclear division|,protein binding|identical protein binding|,10,0,0,10,0.6,0.209,0,0,0.885,-3.8,4.1
ENSMUSG00000024140,EPAS1,endothelial PAS domain protein 1,nucleoplasm|transcription factor complex|transcription factor complex|cytosol|,angiogenesis|response to hypoxia|embryonic placenta development|blood vessel remodeling|regulation of heart rate|transcription from RNA polymerase II promoter|mitochondrion organization|signal transduction|visual perception|erythrocyte differentiation|lung development|norepinephrine metabolic process|surfactant homeostasis|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|cell maturation|myoblast fate commitment|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|cellular response to hypoxia|,RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|signal transducer activity|protein binding|transcription factor binding|histone acetyltransferase binding|sequence-specific DNA binding|protein heterodimerization activity|,10,-0.5,0.409,10,0.3,0.189,0,0,0.885,-2.3,1.8
ENSMUSG00000041559,FMOD,fibromodulin,extracellular region|proteinaceous extracellular matrix|extracellular space|Golgi lumen|extracellular matrix|lysosomal lumen|,carbohydrate metabolic process|transforming growth factor beta receptor complex assembly|keratan sulfate biosynthetic process|extracellular matrix organization|glycosaminoglycan metabolic process|keratan sulfate metabolic process|keratan sulfate catabolic process|small molecule metabolic process|,None,10,-0.1,0.0277,10,0,0,0,0,0.885,-3.7,4
ENSMUSG00000026285,PDCD1,programmed cell death 1,plasma membrane|external side of plasma membrane|integral component of membrane|,apoptotic process|humoral immune response|signal transduction|multicellular organismal development|T cell costimulation|,signal transducer activity|protein binding|,9,-0.1,0.0126,10,0,0,0,0,0.885,-2,2
ENSMUSG00000058624,GDA,guanine deaminase,intracellular|cytosol|extracellular vesicular exosome|,nucleobase-containing compound metabolic process|purine nucleobase metabolic process|guanine catabolic process|purine nucleotide catabolic process|nervous system development|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,zinc ion binding|guanine deaminase activity|,10,0,0,10,0.3,0.0923,0,0,0.885,-3.2,3
ENSMUSG00000021994,WNT5A,"wingless-type MMTV integration site family, member 5A",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|clathrin-coated endocytic vesicle membrane|extracellular vesicular exosome|,"activation of MAPK activity|ameboidal cell migration|establishment of planar polarity|somitogenesis|epithelial to mesenchymal transition|neural tube closure|positive regulation of endothelial cell proliferation|heart looping|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of cytokine secretion involved in immune response|type B pancreatic cell development|optic cup formation involved in camera-type eye development|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|Wnt signaling pathway, calcium modulating pathway|activation of JUN kinase activity|activation of JUN kinase activity|axon guidance|hindgut morphogenesis|midgut development|male gonad development|anterior/posterior axis specification, embryo|response to organic substance|positive regulation of endothelial cell migration|positive regulation of peptidyl-threonine phosphorylation|positive regulation of T cell chemotaxis|positive regulation of neuron projection development|Wnt signaling pathway|olfactory bulb interneuron development|neuron differentiation|neuron differentiation|keratinocyte differentiation|lung development|negative regulation of BMP signaling pathway|positive regulation of cGMP metabolic process|activation of protein kinase B activity|positive regulation of interferon-gamma production|positive regulation of interleukin-6 production|positive regulation of peptidyl-serine phosphorylation|cellular protein localization|post-anal tail morphogenesis|non-canonical Wnt signaling pathway via JNK cascade|negative regulation of fibroblast growth factor receptor signaling pathway|wound healing|embryonic digit morphogenesis|positive regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of chemokine biosynthetic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|positive regulation of angiogenesis|positive regulation of ossification|positive regulation of meiosis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of fibroblast proliferation|embryonic skeletal system development|genitalia development|negative regulation of axon extension involved in axon guidance|hypophysis morphogenesis|negative regulation of epithelial cell proliferation|positive regulation of interleukin-1 beta secretion|positive regulation of inflammatory response|negative chemotaxis|positive regulation of NF-kappaB transcription factor activity|cartilage development|negative regulation of synapse assembly|palate development|convergent extension involved in organogenesis|uterus development|cervix development|vagina development|canonical Wnt signaling pathway|urinary bladder development|face development|positive regulation of type I interferon-mediated signaling pathway|lateral sprouting involved in mammary gland duct morphogenesis|mesenchymal-epithelial cell signaling|negative regulation of prostatic bud formation|mammary gland branching involved in thelarche|epithelial cell proliferation involved in mammary gland duct elongation|positive regulation of response to cytokine stimulus|regulation of branching involved in mammary gland duct morphogenesis|positive regulation of macrophage cytokine production|positive regulation of cartilage development|planar cell polarity pathway involved in outflow tract morphogenesis|planar cell polarity pathway involved in ventricular septum morphogenesis|planar cell polarity pathway involved in cardiac right atrium morphogenesis|planar cell polarity pathway involved in cardiac muscle tissue morphogenesis|planar cell polarity pathway involved in pericardium morphogenesis|positive regulation of thymocyte apoptotic process|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to retinoic acid|cellular response to interferon-gamma|hematopoietic stem cell proliferation|dopaminergic neuron differentiation|cellular response to transforming growth factor beta stimulus|negative regulation of mesenchymal cell proliferation|primitive streak formation|positive regulation of protein kinase C signaling|negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of interleukin-8 secretion|",sequence-specific DNA binding transcription factor activity|frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|cytokine activity|protein domain specific binding|transcription regulatory region DNA binding|receptor agonist activity|,10,0,0,10,0.3,0.128,0,0,0.885,-2.8,2.8
ENSMUSG00000022546,GPT,glutamic-pyruvate transaminase (alanine aminotransferase),cytosol|extracellular vesicular exosome|,cellular amino acid biosynthetic process|cellular nitrogen compound metabolic process|L-alanine catabolic process|small molecule metabolic process|,L-alanine:2-oxoglutarate aminotransferase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding|,10,-2.7,0.35,10,0,0,0,0,0.885,-6.1,3.4
ENSMUSG00000038393,TXNIP,thioredoxin interacting protein,nucleus|cytoplasm|mitochondrial intermembrane space|cytosol|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|protein import into nucleus|cell cycle|response to mechanical stimulus|response to glucose|keratinocyte differentiation|response to estradiol|response to progesterone|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|regulation of cell proliferation|response to drug|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of catalytic activity|innate immune response|platelet-derived growth factor receptor signaling pathway|response to calcium ion|negative regulation of cell division|cellular response to tumor cell|",enzyme inhibitor activity|protein binding|ubiquitin protein ligase binding|,9,-1.2,0.0645,9,0,0,0,0,0.885,-3.8,2.7
ENSMUSG00000069053,UBA1Y,"ubiquitin-activating enzyme, Chr Y",nucleus|cytosol|,cellular protein modification process|protein ubiquitination|modification-dependent protein catabolic process|,nucleotide binding|catalytic activity|ubiquitin activating enzyme activity|ubiquitin-protein transferase activity|ATP binding|small protein activating enzyme activity|ligase activity|,10,0.7,0.373,10,0,0,0,0,0.885,-3.4,3.6
ENSMUSG00000097328,TNFSF12,"tumor necrosis factor (ligand) superfamily, member 12",extracellular space|extracellular space|integral component of plasma membrane|perinuclear region of cytoplasm|,angiogenesis|positive regulation of endothelial cell proliferation|apoptotic process|immune response|signal transduction|cell differentiation|endothelial cell migration|positive regulation of angiogenesis|apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|,receptor binding|cytokine activity|cytokine activity|tumor necrosis factor receptor binding|protein binding|,10,0,0,10,0.8,0.317,0,0,0.885,-5.3,4.1
ENSMUSG00000030093,WNT7A,"wingless-type MMTV integration site family, member 7A",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|,"embryonic axis specification|cartilage condensation|chondrocyte differentiation|neurotransmitter secretion|sex differentiation|asymmetric protein localization|dorsal/ventral pattern formation|skeletal muscle satellite cell activation|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|cerebellar granule cell differentiation|cell proliferation in forebrain|central nervous system vasculogenesis|establishment of cell polarity|neuron differentiation|regulation of axon diameter|response to estradiol|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|non-canonical Wnt signaling pathway|Wnt signaling pathway involved in wound healing, spreading of epidermal cells|embryonic digit morphogenesis|negative regulation of apoptotic process|cell fate commitment|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|somatic stem cell division|stem cell development|negative regulation of neurogenesis|synapse organization|positive regulation of synapse assembly|palate development|positive regulation of epithelial cell proliferation involved in wound healing|oviduct development|canonical Wnt signaling pathway|uterus morphogenesis|lens fiber cell development|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|",receptor binding|frizzled binding|cytokine activity|receptor agonist activity|receptor agonist activity|,10,0,0,10,0,0,0,0,0.885,-6.5,3
ENSMUSG00000031862,ATP13A1,ATPase type 13A1,cellular_component|endoplasmic reticulum membrane|membrane|integral component of membrane|,ATP catabolic process|cation transport|biological_process|,molecular_function|ATP binding|cation-transporting ATPase activity|metal ion binding|,10,0,0,10,-0.8,0.272,0,0,0.885,-8,3
ENSMUSG00000016382,PLS3,plastin 3,cytoplasm|,bone development|,actin binding|calcium ion binding|,10,0.1,0.0163,10,0,0,0,0,0.885,-2.7,2.9
ENSMUSG00000063089,KLK1B8,kallikrein 1-related peptidase b8,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,10,-0.3,0.0812,10,0.5,0.0881,0,0,0.885,-7.6,3.7
ENSMUSG00000004446,BID,BH3 interacting domain death agonist,mitochondrion|mitochondrial outer membrane|cytosol|membrane|integral component of mitochondrial membrane|extracellular vesicular exosome|,release of cytochrome c from mitochondria|protein targeting to mitochondrion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|brain development|extrinsic apoptotic signaling pathway via death domain receptors|apoptotic mitochondrial changes|response to estradiol|positive regulation of protein oligomerization|positive regulation of protein homooligomerization|glial cell apoptotic process|regulation of cell proliferation|signal transduction in response to DNA damage|positive regulation of apoptotic process|protein homooligomerization|neuron apoptotic process|establishment of protein localization to membrane|positive regulation of release of cytochrome c from mitochondria|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of mitochondrial membrane permeability involved in apoptotic process|regulation of G1/S transition of mitotic cell cycle|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,death receptor binding|protein binding|ubiquitin protein ligase binding|,10,-0.9,0.655,10,0,0,0,0,0.885,-3.2,1.7
ENSMUSG00000070808,GLTSCR1,glioma tumor suppressor candidate region gene 1,None,None,protein binding|,10,-0.1,0.00988,10,0,0,0,0,0.885,-5.5,2.7
ENSMUSG00000021549,RASA1,RAS p21 protein activator (GTPase activating protein) 1,ruffle|cytoplasm|cytoplasm|cytosol|intrinsic component of the cytoplasmic side of the plasma membrane|,mitotic cytokinesis|vasculogenesis|negative regulation of cell-matrix adhesion|negative regulation of cell adhesion|signal transduction|regulation of cell shape|embryo development|regulation of actin filament polymerization|positive regulation of Ras GTPase activity|intracellular signal transduction|negative regulation of neuron apoptotic process|negative regulation of Ras protein signal transduction|regulation of RNA metabolic process|,glycoprotein binding|Ras GTPase activator activity|receptor binding|protein binding|potassium channel inhibitor activity|GTPase binding|,10,-2.4,1.14,10,0,0,0,0,0.885,-5.1,2.1
ENSMUSG00000039989,CBX4,chromobox homolog 4,nucleus|nucleoplasm|nuclear speck|PcG protein complex|PRC1 complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|chromatin modification|protein sumoylation|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|",chromatin binding|transcription corepressor activity|single-stranded RNA binding|protein binding|ligase activity|enzyme binding|SUMO binding|methylated histone binding|transcription regulatory region DNA binding|phosphoprotein binding|,10,0,0,10,0.5,0.187,0,0,0.885,-4.2,3.7
ENSMUSG00000038241,CEP250,centrosomal protein 250kDa,centrosome|centriole|centriole|microtubule organizing center|cytosol|cilium|spindle pole centrosome|protein complex|perinuclear region of cytoplasm|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic cell cycle|protein localization|centriole-centriole cohesion|regulation of centriole-centriole cohesion|protein localization to organelle|,protein binding|protein C-terminus binding|protein kinase binding|protein domain specific binding|,10,0,0,10,0,0,0,0,0.885,-2.3,1.8
ENSMUSG00000027528,FABP9,"fatty acid binding protein 9, testis",acrosomal vesicle|,acrosome assembly|transport|,transporter activity|lipid binding|,9,0,0,10,5.8,1.72,0,0,0.885,-6.1,12
ENSMUSG00000039530,TUSC3,tumor suppressor candidate 3,mitochondrion|endoplasmic reticulum membrane|integral component of plasma membrane|oligosaccharyltransferase complex|,protein N-linked glycosylation|magnesium ion transport|magnesium ion transport|protein N-linked glycosylation via asparagine|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|cell redox homeostasis|cognition|,dolichyl-diphosphooligosaccharide-protein glycotransferase activity|magnesium ion transmembrane transporter activity|,10,0,0,9,-0.5,0.0532,0,0,0.885,-3,2.5
ENSMUSG00000092609,GM20481,N/A,None,None,None,2,0,0,2,-0.2,0.0276,0,0,0.885,-2,1.8
ENSMUSG00000031844,HSD17B2,hydroxysteroid (17-beta) dehydrogenase 2,endoplasmic reticulum membrane|integral component of membrane|,in utero embryonic development|placenta development|steroid biosynthetic process|response to retinoic acid|oxidation-reduction process|,"estradiol 17-beta-dehydrogenase activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|",10,0,0,10,0,0,0,0,0.885,-3.4,3.8
ENSMUSG00000002983,RELB,v-rel avian reticuloendotheliosis viral oncogene homolog B,nucleus|cytoplasm|microtubule organizing center|cytosol|,"transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of gene expression|antigen processing and presentation|circadian regulation of gene expression|myeloid dendritic cell differentiation|T-helper 1 cell differentiation|",core promoter binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|protein binding|,10,3.5,0.146,10,0,0,0,0,0.885,-3.8,7.7
ENSMUSG00000006389,MPL,"MPL proto-oncogene, thrombopoietin receptor",plasma membrane|plasma membrane|integral component of plasma membrane|,cell surface receptor signaling pathway|blood coagulation|cell proliferation|cytokine-mediated signaling pathway|platelet activation|regulation of chemokine production|homeostasis of number of cells|,transmembrane signaling receptor activity|cytokine receptor activity|,10,-1.4,0.211,10,0,0,0,0,0.885,-6.2,2.7
ENSMUSG00000029546,UNCX,UNC homeobox,nucleus|,"cartilage condensation|transcription, DNA-templated|regulation of transcription, DNA-templated|pattern specification process|dorsal spinal cord development|olfactory bulb interneuron differentiation|common myeloid progenitor cell proliferation|regulation of cell differentiation|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0,0,10,-0.1,0.00973,0,0,0.885,-5.8,3.6
ENSMUSG00000022994,ADCY6,adenylate cyclase 6,plasma membrane|cilium|membrane|integral component of membrane|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|dopamine receptor signaling pathway|synaptic transmission|fibroblast growth factor receptor signaling pathway|negative regulation of neuron projection development|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|,adenylate cyclase activity|protein binding|ATP binding|protein kinase binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2
ENSMUSG00000021983,ATP8A2,"ATPase, aminophospholipid transporter, class I, type 8A, member 2",photoreceptor outer segment|endosome|Golgi apparatus|plasma membrane|integral component of membrane|,involuntary skeletal muscle contraction|cation transport|axonogenesis|aging|metabolic process|negative regulation of cell proliferation|positive regulation of multicellular organism growth|eating behavior|skin development|phospholipid translocation|neuromuscular process controlling posture|,magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|cation-transporting ATPase activity|,10,-0.1,0.0138,10,0,0,0,0,0.885,-7.6,3
ENSMUSG00000022178,AJUBA,ajuba LIM protein,cytoplasmic mRNA processing body|nucleus|transcription factor complex|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|focal adhesion|lamellipodium|,"G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|response to hypoxia|transcription, DNA-templated|calcium-dependent cell-cell adhesion|lamellipodium assembly|regulation of cell migration|positive regulation of cellular biosynthetic process|positive regulation of protein complex assembly|negative regulation of kinase activity|cellular protein localization|gene silencing by miRNA|wound healing, spreading of epidermal cells|negative regulation of hippo signaling|regulation of GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|glycerophospholipid biosynthetic process|focal adhesion assembly|regulation of cellular response to hypoxia|positive regulation of gene silencing by miRNA|",chromatin binding|transcription corepressor activity|protein binding|zinc ion binding|alpha-catenin binding|actin filament binding|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000038256,BCL9,B-cell CLL/lymphoma 9,nucleus|Golgi apparatus|cis-Golgi network|,myotube differentiation involved in skeletal muscle regeneration|somatic stem cell maintenance|skeletal muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|,protein binding|beta-catenin binding|,10,0,0,10,0,0,0,0,0.885,-3.7,3.5
ENSMUSG00000018965,YWHAH,"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta",cytoplasm|cytosol|plasma membrane|intercalated disc|cytoplasmic vesicle membrane|extracellular vesicular exosome|,"regulation of sodium ion transport|glucocorticoid catabolic process|intracellular protein transport|apoptotic process|substantia nigra development|glucocorticoid receptor signaling pathway|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|regulation of synaptic plasticity|negative regulation of dendrite morphogenesis|membrane organization|membrane depolarization during action potential|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of sodium ion transmembrane transporter activity|",actin binding|insulin-like growth factor receptor binding|protein binding|sodium channel regulator activity|enzyme binding|protein domain specific binding|glucocorticoid receptor binding|ion channel binding|protein heterodimerization activity|,10,-0.5,0.217,10,0,0,0,0,0.885,-5.2,4.2
ENSMUSG00000016664,PACSIN2,protein kinase C and casein kinase substrate in neurons 2,nucleus|cytoplasm|early endosome|cytosol|cytoskeleton|caveola|extrinsic component of membrane|cytoplasmic vesicle membrane|ruffle membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular vesicular exosome|,actin cytoskeleton organization|protein localization to endosome|negative regulation of endocytosis|cell projection morphogenesis|caveola assembly|caveolin-mediated endocytosis|membrane tubulation|membrane tubulation|,transporter activity|protein binding|cytoskeletal protein binding|identical protein binding|phosphatidic acid binding|,10,0,0,10,0,0,0,0,0.885,-2.7,2.2
ENSMUSG00000047417,REXO1,"REX1, RNA exonuclease 1 homolog (S. cerevisiae)",nucleus|,nucleic acid phosphodiester bond hydrolysis|,nucleic acid binding|exonuclease activity|,1,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000025218,POLL,"polymerase (DNA directed), lambda",nucleus|,DNA replication|DNA-dependent DNA replication|DNA-dependent DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes|,DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding|,10,0.4,0.246,10,0,0,0,0,0.885,-2.5,3.2
ENSMUSG00000078945,NAIP2,"NLR family, apoptosis inhibitory protein 2",extracellular vesicular exosome|IPAF inflammasome complex|,immune system process|apoptotic process|inflammatory response|detection of bacterium|defense response to bacterium|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|pyroptosis|cellular response to estrogen stimulus|,nucleotide binding|ATP binding|metal ion binding|,10,-1.1,0.0445,9,0.1,0.0155,0,0,0.885,-5.9,2
ENSMUSG00000024218,TAF11,"TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa",nucleus|nucleoplasm|transcription factor TFIID complex|Golgi apparatus|,"regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|gene expression|viral process|positive regulation by host of viral transcription|",DNA binding|transcription coactivator activity|protein binding|vitamin D receptor binding|thyroid hormone receptor binding|protein heterodimerization activity|protein N-terminus binding|,10,-1.6,1.53,10,4.8,0.827,0,0,0.885,-5.1,8.3
ENSMUSG00000022015,TNFSF11,"tumor necrosis factor (ligand) superfamily, member 11",extracellular region|extracellular space|cytoplasm|integral component of plasma membrane|,ossification|osteoclast proliferation|monocyte chemotaxis|immune response|activation of JUN kinase activity|organ morphogenesis|cytokine-mediated signaling pathway|osteoclast differentiation|osteoclast differentiation|osteoclast differentiation|tumor necrosis factor-mediated signaling pathway|mammary gland epithelial cell proliferation|positive regulation of homotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|bone resorption|positive regulation of osteoclast differentiation|positive regulation of bone resorption|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of T cell activation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein homooligomerization|positive regulation of corticotropin-releasing hormone secretion|positive regulation of protein kinase B signaling|calcium ion homeostasis|mammary gland alveolus development|ERK1 and ERK2 cascade|positive regulation of fever generation by positive regulation of prostaglandin secretion|TNFSF11-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of intracellular signal transduction|,cytokine activity|cytokine activity|tumor necrosis factor receptor binding|tumor necrosis factor receptor superfamily binding|,10,0.5,0.166,10,0,0,0,0,0.885,-3.1,2.6
ENSMUSG00000019718,L3HYPDH,L-3-hydroxyproline dehydratase (trans-),None,metabolic process|,hydro-lyase activity|trans-L-3-hydroxyproline dehydratase activity|,10,0,0,10,0,0,0,0,0.885,-2.3,1.9
ENSMUSG00000026728,VIM,vimentin,cytoplasm|peroxisome|cytosol|cytosol|cytoskeleton|cytoskeleton|intermediate filament|plasma membrane|cell leading edge|cell projection|intermediate filament cytoskeleton|extracellular vesicular exosome|,apoptotic process|cellular component disassembly involved in execution phase of apoptosis|cellular component movement|negative regulation of neuron projection development|astrocyte development|viral process|muscle filament sliding|intermediate filament organization|Bergmann glial cell differentiation|lens fiber cell development|,glycoprotein binding|double-stranded RNA binding|structural constituent of cytoskeleton|structural constituent of eye lens|protein binding|protein C-terminus binding|identical protein binding|scaffold protein binding|,10,0,0,10,0,0,0,0,0.885,-4.5,1.9
ENSMUSG00000004872,PAX3,paired box 3,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|neural tube closure|transcription from RNA polymerase II promoter|apoptotic process|heart development|muscle organ development|sensory perception of sound|cell proliferation|positive regulation of cell proliferation|organ morphogenesis|regulation of somitogenesis|spinal cord association neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|developmental pigmentation|neuron fate commitment|mammary gland specification|",chromatin binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|sequence-specific DNA binding|HMG box domain binding|,10,0,0,10,0.4,0.17,0,0,0.885,-2.9,2
ENSMUSG00000079243,XIRP1,xin actin-binding repeat containing 1,fascia adherens|,negative regulation of cell proliferation|regulation of membrane potential|sarcomere organization|cardiac muscle cell development|,actin binding|poly(A) RNA binding|,10,0,0,10,0.1,0.0217,0,0,0.885,-2.8,3.7
ENSMUSG00000027840,WNT2B,"wingless-type MMTV integration site family, member 2B",extracellular region|proteinaceous extracellular matrix|extracellular space|,chondrocyte differentiation|lens development in camera-type eye|male gonad development|Wnt signaling pathway|forebrain regionalization|neuron differentiation|neuron differentiation|cell fate commitment|canonical Wnt signaling pathway|lung induction|mesenchymal-epithelial cell signaling|iris morphogenesis|cornea development in camera-type eye|hematopoietic stem cell proliferation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt signaling pathway|,frizzled binding|,10,-5.5,2.06,10,0,0,0,0,0.885,-10.7,2.1
ENSMUSG00000024077,STRN,"striatin, calmodulin binding protein",protein phosphatase type 2A complex|cytoplasm|tight junction|postsynaptic density|membrane|neuronal cell body|dendritic spine|postsynaptic membrane|,locomotory behavior|negative regulation of cell proliferation|Wnt signaling pathway|dendrite development|tight junction assembly|,protein binding|calmodulin binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding|armadillo repeat domain binding|,2,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000030579,TYROBP,TYRO protein tyrosine kinase binding protein,plasma membrane|integral component of plasma membrane|cell surface|,macrophage activation involved in immune response|neutrophil activation involved in immune response|cellular defense response|signal transduction|integrin-mediated signaling pathway|axon guidance|intracellular signal transduction|innate immune response|regulation of immune response|regulation of osteoclast development|,receptor signaling protein activity|receptor binding|protein binding|identical protein binding|,10,-1.9,1.4,9,0,0,0,0,0.885,-6.3,1.8
ENSMUSG00000030559,RAB38,"RAB38, member RAS oncogene family",early endosome|cytosol|plasma membrane|membrane|phagocytic vesicle membrane|melanosome|phagocytic vesicle|,GTP catabolic process|small GTPase mediated signal transduction|protein transport|melanosome organization|endosome to melanosome transport|platelet dense granule organization|protein localization to membrane|phagosome acidification|,GTPase activity|protein binding|GTP binding|GTP-dependent protein binding|protein complex binding|AP-1 adaptor complex binding|AP-3 adaptor complex binding|,10,0,0,10,0,0,0,0,0.885,-5,3.7
ENSMUSG00000027871,HSD3B1,"hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1",mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum membrane|integral component of membrane|smooth endoplasmic reticulum membrane|,steroid biosynthetic process|androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|steroid metabolic process|small molecule metabolic process|oxidation-reduction process|,3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid delta-isomerase activity|,10,-0.4,0.165,10,0,0,0,0,0.885,-1.9,1.5
ENSMUSG00000057265,CCDC176,coiled-coil domain containing 176,cytoplasm|ciliary basal body|,motile cilium assembly|,None,10,-0.4,0.0406,10,0,0,0,0,0.885,-4.7,8.4
ENSMUSG00000037705,TECTA,tectorin alpha,proteinaceous extracellular matrix|plasma membrane|anchored component of membrane|extracellular vesicular exosome|,cell-matrix adhesion|sensory perception of sound|,None,10,0,0,9,1.3,1.04,0,0,0.885,-2.4,3.9
ENSMUSG00000029344,TPST2,tyrosylprotein sulfotransferase 2,Golgi membrane|endoplasmic reticulum|membrane|integral component of membrane|extracellular vesicular exosome|,peptidyl-tyrosine sulfation|fusion of sperm to egg plasma membrane|prevention of polyspermy|,protein-tyrosine sulfotransferase activity|,10,0.2,0.0121,10,0,0,0,0,0.885,-1.9,2.9
ENSMUSG00000019899,LAMA2,"laminin, alpha 2",extracellular region|basement membrane|laminin-1 complex|extracellular matrix|sarcolemma|dendritic spine|extracellular vesicular exosome|,"cell adhesion|axon guidance|muscle organ development|myelination in peripheral nervous system|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|positive regulation of synaptic transmission, cholinergic|regulation of embryonic development|",receptor binding|structural molecule activity|,10,0,0,10,-0.5,0.321,0,0,0.885,-3.5,2.8
ENSMUSG00000031328,FLNA,"filamin A, alpha",extracellular region|nucleus|cytoplasm|trans-Golgi network|cytosol|actin filament|plasma membrane|actin cytoskeleton|actin cytoskeleton|membrane|cortical cytoskeleton|Myb complex|neuronal cell body|dendritic shaft|perinuclear region of cytoplasm|extracellular vesicular exosome|apical dendrite|,epithelial to mesenchymal transition|platelet degranulation|adenylate cyclase-inhibiting dopamine receptor signaling pathway|blood coagulation|platelet activation|actin cytoskeleton reorganization|cell junction assembly|protein localization to cell surface|negative regulation of protein catabolic process|cilium assembly|mRNA transcription from RNA polymerase II promoter|positive regulation of transcription factor import into nucleus|receptor clustering|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of sequence-specific DNA binding transcription factor activity|early endosome to late endosome transport|establishment of protein localization|protein stabilization|cytoplasmic sequestering of protein|actin crosslink formation|spindle assembly involved in mitosis|,glycoprotein binding|signal transducer activity|protein kinase C binding|protein binding|transcription factor binding|Rho GTPase binding|Ral GTPase binding|small GTPase binding|mu-type opioid receptor binding|Fc-gamma receptor I complex binding|protein homodimerization activity|poly(A) RNA binding|SMAD binding|Rac GTPase binding|actin filament binding|,10,0,0,10,0,0,0,0,0.885,-3,2.7
ENSMUSG00000028124,GCLM,"glutamate-cysteine ligase, modifier subunit",cytosol|cytosol|glutamate-cysteine ligase complex|,sulfur amino acid metabolic process|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|glutathione biosynthetic process|glutathione biosynthetic process|glutathione biosynthetic process|xenobiotic metabolic process|response to oxidative stress|apoptotic mitochondrial changes|cellular nitrogen compound metabolic process|positive regulation of glutamate-cysteine ligase activity|response to drug|negative regulation of neuron apoptotic process|small molecule metabolic process|regulation of blood vessel size|response to nitrosative stress|regulation of mitochondrial depolarization|glutathione derivative biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway|,glutamate-cysteine ligase activity|glutamate-cysteine ligase activity|glutamate-cysteine ligase catalytic subunit binding|protein heterodimerization activity|,10,0,0,10,0.4,0.129,0,0,0.885,-3.3,4.7
ENSMUSG00000024868,DKK1,dickkopf WNT signaling pathway inhibitor 1,extracellular space|plasma membrane|,negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis involved in differentiation|endoderm formation|mesoderm formation|hair follicle development|regulation of receptor internalization|negative regulation of Wnt signaling pathway|embryonic limb morphogenesis|negative regulation of BMP signaling pathway|forebrain development|negative regulation of protein complex assembly|response to retinoic acid|negative regulation of peptidyl-serine phosphorylation|negative regulation of mesodermal cell fate specification|regulation of endodermal cell fate specification|negative regulation of skeletal muscle tissue development|face morphogenesis|negative regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|Wnt signaling pathway involved in somitogenesis|extracellular negative regulation of signal transduction|negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|negative regulation of cardiac muscle cell differentiation|,signal transducer activity|protein binding|growth factor activity|receptor antagonist activity|low-density lipoprotein particle receptor binding|,10,-0.7,0.22,10,0,0,0,0,0.885,-3.3,2.4
ENSMUSG00000058486,WDR91,WD repeat domain 91,None,None,None,10,0.6,0.775,10,-0.3,0.157,0,0,0.885,-3.4,2.8
ENSMUSG00000001656,HOXC11,homeobox C11,nucleus|cytoplasm|,"metanephros development|organ induction|transcription, DNA-templated|endoderm development|anterior/posterior pattern specification|proximal/distal pattern formation|embryonic digit morphogenesis|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal joint morphogenesis|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|,10,-0.2,0.0351,10,0,0,0,0,0.885,-5.3,3.4
ENSMUSG00000032193,LDLR,low density lipoprotein receptor,lysosome|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|coated pit|external side of plasma membrane|cell surface|endosome membrane|membrane|clathrin-coated endocytic vesicle membrane|low-density lipoprotein particle|receptor complex|,"retinoid metabolic process|lipid metabolic process|endocytosis|receptor-mediated endocytosis|phototransduction, visible light|cholesterol metabolic process|positive regulation of triglyceride biosynthetic process|regulation of phosphatidylcholine catabolic process|phospholipid transport|viral process|intestinal cholesterol absorption|cholesterol transport|low-density lipoprotein particle clearance|lipoprotein metabolic process|lipoprotein catabolic process|cholesterol homeostasis|small molecule metabolic process|cholesterol import|",glycoprotein binding|low-density lipoprotein receptor activity|calcium ion binding|protein binding|low-density lipoprotein particle binding|very-low-density lipoprotein particle receptor activity|,10,0,0,10,0,0,0,0,0.885,-8,3.9
ENSMUSG00000031536,POLB,"polymerase (DNA directed), beta",nucleus|nucleoplasm|cytoplasm|microtubule|spindle microtubule|,"DNA-dependent DNA replication|DNA repair|base-excision repair|base-excision repair|base-excision repair|base-excision repair, gap-filling|pyrimidine dimer repair|cellular response to DNA damage stimulus|intrinsic apoptotic signaling pathway in response to DNA damage|response to ethanol|neuron apoptotic process|DNA biosynthetic process|",damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|microtubule binding|lyase activity|enzyme binding|metal ion binding|,10,-2,0.452,10,0,0,0,0,0.885,-4.4,2.7
ENSMUSG00000038530,RGS4,regulator of G-protein signaling 4,cytoplasm|cytosol|plasma membrane|protein complex|,inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway|termination of G-protein coupled receptor signaling pathway|positive regulation of GTPase activity|,G-protein alpha-subunit binding|GTPase activator activity|calmodulin binding|,10,0,0,10,0,0,0,0,0.885,-2.7,3
ENSMUSG00000003346,ABHD17A,abhydrolase domain containing 17A,cellular_component|extracellular region|membrane|,biological_process|metabolic process|,protein binding|hydrolase activity|,10,0,0,10,0,0,0,0,0.885,-1.7,2.5
ENSMUSG00000029202,PDS5A,"PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)","chromosome, centromeric region|chromatin|nucleus|nucleoplasm|chromosome|cytosol|plasma membrane|",mitotic cell cycle|mitotic nuclear division|negative regulation of DNA replication|,protein binding|,10,0,0,10,0.1,0.00627,0,0,0.885,-4.1,4.5
ENSMUSG00000006270,VAX1,ventral anterior homeobox 1,nucleus|,"negative regulation of transcription from RNA polymerase II promoter|neuron migration|transcription, DNA-templated|negative regulation of neuroblast proliferation|axon guidance|brain development|skeletal muscle cell differentiation|camera-type eye development|palate development|",transcription regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|chromatin DNA binding|,10,0.1,0.0242,10,0,0,0,0,0.885,-3.1,2.5
ENSMUSG00000028411,APTX,aprataxin,chromatin|nuclear chromatin|nucleus|nucleoplasm|nucleolus|cytoplasm|,"single strand break repair|DNA catabolic process, exonucleolytic|DNA catabolic process, exonucleolytic|DNA ligation|double-strand break repair|cellular response to DNA damage stimulus|cell death|dephosphorylation|regulation of protein stability|response to hydrogen peroxide|polynucleotide 3' dephosphorylation|",chromatin binding|damaged DNA binding|double-stranded DNA binding|double-stranded RNA binding|protein binding|phosphoglycolate phosphatase activity|DNA 5'-adenosine monophosphate hydrolase activity|polynucleotide 3'-phosphatase activity|metal ion binding|protein N-terminus binding|phosphoprotein binding|,10,0,0,10,0,0,0,0,0.885,-5.3,2
ENSMUSG00000051498,TLR6,toll-like receptor 6,plasma membrane|integral component of plasma membrane|phagocytic vesicle membrane|Toll-like receptor 2-Toll-like receptor 6 protein complex|,toll-like receptor signaling pathway|microglial cell activation involved in immune response|MyD88-dependent toll-like receptor signaling pathway|inflammatory response|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 6 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|T-helper 1 type immune response|detection of diacyl bacterial lipopeptide|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JUN kinase activity|innate immune response|positive regulation of interleukin-6 biosynthetic process|nitric oxide metabolic process|regulation of cytokine secretion|pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response|cellular response to diacyl bacterial lipopeptide|,receptor activity|transmembrane signaling receptor activity|diacyl lipopeptide binding|protein heterodimerization activity|lipopeptide binding|,10,0.5,0.432,10,0,0,0,0,0.885,-3,2.6
ENSMUSG00000015829,TNR,tenascin R,extracellular region|proteinaceous extracellular matrix|nucleus|cytoplasm|cell surface|membrane raft|perineuronal net|,"cell adhesion|neuron cell-cell adhesion|axon guidance|associative learning|telencephalon cell migration|negative regulation of cell-cell adhesion|extracellular matrix organization|locomotory exploration behavior|negative regulation of axon extension involved in regeneration|negative regulation of synaptic transmission|synapse organization|neuromuscular process controlling balance|positive regulation of synaptic transmission, glutamatergic|positive regulation of transmission of nerve impulse|long-term synaptic potentiation|",None,10,0,0,10,0,0,0,0,0.885,-2.6,2.3
ENSMUSG00000046186,CD109,CD109 molecule,extracellular space|plasma membrane|anchored component of membrane|,negative regulation of endopeptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of wound healing|,serine-type endopeptidase inhibitor activity|transforming growth factor beta binding|,10,0,0,10,0,0,0,0,0.885,-2.6,2.4
ENSMUSG00000022261,SDC2,syndecan 2,Golgi lumen|plasma membrane|integral component of membrane|neuronal cell body|lysosomal lumen|,"retinoid metabolic process|response to hypoxia|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|phototransduction, visible light|biological_process|extracellular matrix organization|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|response to caffeine|wound healing|small molecule metabolic process|dendrite morphogenesis|regulation of dendrite morphogenesis|",protein binding|cytoskeletal protein binding|PDZ domain binding|,10,0,0,10,0.4,0.125,0,0,0.885,-2.8,4.4
ENSMUSG00000060201,SPINK7,"serine peptidase inhibitor, Kazal type 7 (putative)",extracellular region|,negative regulation of endopeptidase activity|,serine-type endopeptidase inhibitor activity|protein binding|,10,0,0,10,0.2,0.0303,0,0,0.885,-3.3,3.1
ENSMUSG00000037795,N4BP2,NEDD4 binding protein 2,cytosol|,phosphorylation|nucleic acid phosphodiester bond hydrolysis|,endonuclease activity|protein binding|ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|,10,0.3,0.0423,10,0,0,0,0,0.885,-3.4,2.9
ENSMUSG00000032679,CD59A,CD59a antigen,extracellular region|plasma membrane|external side of plasma membrane|membrane|anchored component of membrane|,cell activation|negative regulation of activation of membrane attack complex|negative regulation of angiogenesis|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of complement activation|negative regulation of fibroblast growth factor production|,complement binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000043384,GPRASP1,G protein-coupled receptor associated sorting protein 1,cytoplasm|,endosome to lysosome transport|G-protein coupled receptor catabolic process|G-protein coupled receptor catabolic process|,protein binding|,10,1.4,0.858,10,0,0,0,0,0.885,-7.6,3.8
ENSMUSG00000040387,KLHL32,kelch-like family member 32,None,None,None,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000000305,CDH4,"cadherin 4, type 1, R-cadherin (retinal)",plasma membrane|plasma membrane|integral component of plasma membrane|,cell adhesion|homophilic cell adhesion|heterophilic cell-cell adhesion|axon guidance|cell junction assembly|adherens junction organization|cell-cell junction organization|positive regulation of axon extension|,calcium ion binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000052387,TRPM3,"transient receptor potential cation channel, subfamily M, member 3",plasma membrane|integral component of membrane|,cation transport|ion transmembrane transport|transmembrane transport|calcium ion transmembrane transport|,cation channel activity|calcium channel activity|,10,0.2,0.00466,10,0,0,0,0,0.885,-4.9,3.1
ENSMUSG00000045636,MTUS1,microtubule associated tumor suppressor 1,extracellular space|nucleus|mitochondrion|Golgi apparatus|microtubule organizing center|spindle|microtubule|plasma membrane|,cellular response to peptide hormone stimulus|,None,10,0,0,10,0,0,0,0,0.885,-3.2,3.2
ENSMUSG00000025804,CCR1,chemokine (C-C motif) receptor 1,plasma membrane|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|,"dendritic cell chemotaxis|calcium ion transport|cellular calcium ion homeostasis|exocytosis|chemotaxis|inflammatory response|immune response|cell adhesion|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|metabolic process|response to wounding|negative regulation of gene expression|cytokine-mediated signaling pathway|negative regulation of bone mineralization|positive regulation of osteoclast differentiation|positive regulation of calcium ion transport|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of monocyte chemotaxis|",phosphatidylinositol phospholipase C activity|chemokine receptor activity|protein binding|C-C chemokine receptor activity|C-C chemokine binding|chemokine (C-C motif) ligand 7 binding|chemokine (C-C motif) ligand 5 binding|,10,0,0,10,0.5,0.142,0,0,0.885,-2,2.8
ENSMUSG00000042961,EGFLAM,"EGF-like, fibronectin type III and laminin G domains",basement membrane|interstitial matrix|cell junction|synapse|,positive regulation of cell-substrate adhesion|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|,glycosaminoglycan binding|,10,0,0,10,-0.3,0.0858,0,0,0.885,-6.4,3.8
ENSMUSG00000034826,NUP54,nucleoporin 54kDa,nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|nuclear membrane|,mitotic cell cycle|carbohydrate metabolic process|protein targeting|nucleocytoplasmic transport|mitotic nuclear envelope disassembly|hexose transport|regulation of glucose transport|glucose transport|viral process|cytokine-mediated signaling pathway|small molecule metabolic process|mRNA transport|transmembrane transport|,nucleocytoplasmic transporter activity|,10,0,0,10,-0.9,0.539,0,0,0.885,-3.9,5.8
ENSMUSG00000044485,KLK1B11,kallikrein 1-related peptidase b11,nucleus|,proteolysis|,catalytic activity|serine-type endopeptidase activity|peptidase activity|serine-type peptidase activity|hydrolase activity|,9,2.1,1.68,9,0,0,0,0,0.885,-6.3,7
ENSMUSG00000027425,CSRP2BP,CSRP2 binding protein,nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|,G2/M transition of mitotic cell cycle|chromatin organization|embryo development|histone H3 acetylation|,histone acetyltransferase activity|protein binding|LIM domain binding|,10,-1,0.978,10,0.2,0.0829,0,0,0.885,-2.6,1.6
ENSMUSG00000018012,RAC3,"ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)",cytosol|plasma membrane|endomembrane system|lamellipodium|growth cone|filamentous actin|neuron projection|neuronal cell body|perinuclear region of cytoplasm|cell periphery|,GTP catabolic process|small GTPase mediated signal transduction|cell projection assembly|actin cytoskeleton organization|neuron projection development|positive regulation of cell adhesion mediated by integrin|intracellular signal transduction|neuromuscular process controlling balance|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading|,GTPase activity|protein binding|GTP binding|calcium-dependent protein binding|,10,0,0,10,0,0,0,0,0.885,-1.8,1.6
ENSMUSG00000055170,IFNG,"interferon, gamma",extracellular region|extracellular region|extracellular space|external side of plasma membrane|,"protein import into nucleus, translocation|negative regulation of transcription from RNA polymerase II promoter|neutrophil apoptotic process|regulation of the force of heart contraction|positive regulation of mesenchymal cell proliferation|adaptive immune response|CD8-positive, alpha-beta T cell differentiation involved in immune response|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|apoptotic process|cellular component movement|humoral immune response|cell cycle arrest|cell surface receptor signaling pathway|response to virus|cytokine-mediated signaling pathway|antigen processing and presentation|neutrophil chemotaxis|endoplasmic reticulum unfolded protein response|negative regulation of myelination|positive regulation of synaptic transmission, cholinergic|negative regulation of interleukin-17 production|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptotic process|positive regulation of T cell proliferation|response to drug|positive regulation of tyrosine phosphorylation of Stat1 protein|defense response to bacterium|defense response to protozoan|negative regulation of growth of symbiont in host|positive regulation of chemokine biosynthetic process|positive regulation of interleukin-12 biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of interleukin-6 biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of neuron differentiation|positive regulation of osteoclast differentiation|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|positive regulation of isotype switching to IgG isotypes|negative regulation of smooth muscle cell proliferation|positive regulation of interleukin-1 beta secretion|regulation of insulin secretion|positive regulation of membrane protein ectodomain proteolysis|defense response to virus|positive regulation of killing of cells of other organism|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of vitamin D biosynthetic process|positive regulation of calcidiol 1-monooxygenase activity|cellular response to lipopolysaccharide|cellular response to interleukin-18|negative regulation of metanephric nephron tubule epithelial cell differentiation|extrinsic apoptotic signaling pathway|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|",cytokine activity|interferon-gamma receptor binding|,10,-0.2,0.0786,10,0,0,0,0,0.885,-4.5,2.8
ENSMUSG00000024029,TFF3,trefoil factor 3 (intestinal),extracellular region|secretory granule|apical lamina of hyaline layer|extracellular vesicular exosome|,defense response|digestion|response to peptide hormone|,molecular_function|,10,0.4,0.144,10,-0.6,0.192,0,0,0.885,-4,3
ENSMUSG00000032418,ME1,"malic enzyme 1, NADP(+)-dependent, cytosolic",mitochondrion|cytosol|cytosol|,carbohydrate metabolic process|malate metabolic process|NADP biosynthetic process|response to hormone|response to carbohydrate|cellular lipid metabolic process|small molecule metabolic process|protein tetramerization|oxidation-reduction process|,malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|oxaloacetate decarboxylase activity|electron carrier activity|manganese ion binding|ADP binding|NADP binding|NAD binding|,10,-1.8,0.429,10,0,0,0,0,0.885,-5.9,2
ENSMUSG00000044339,ALKBH2,"alkB, alkylation repair homolog 2 (E. coli)",nucleoplasm|,DNA repair|DNA dealkylation involved in DNA repair|DNA dealkylation involved in DNA repair|oxidative DNA demethylation|oxidative demethylation|DNA demethylation|,ferrous iron binding|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|cytosine C-5 DNA demethylase activity|,9,-0.2,0.0224,9,0,0,0,0,0.885,-2.6,1.7
ENSMUSG00000031388,NAA10,"N(alpha)-acetyltransferase 10, NatA catalytic subunit",intracellular|nucleus|nucleolus|cytoplasm|membrane|NatA complex|,DNA packaging|N-terminal protein amino acid acetylation|internal protein amino acid acetylation|,peptide alpha-N-acetyltransferase activity|protein binding|N-acetyltransferase activity|acetyltransferase activity|ribosome binding|,9,-5,0.427,10,1.1,0.107,0,0,0.885,-9.3,3.7
ENSMUSG00000000385,TMPRSS2,"transmembrane protease, serine 2",plasma membrane|integral component of plasma membrane|extracellular vesicular exosome|,proteolysis|receptor-mediated endocytosis|protein autoprocessing|positive regulation of viral entry into host cell|,serine-type endopeptidase activity|scavenger receptor activity|protein binding|serine-type peptidase activity|,10,0,0,10,0,0,0,0,0.885,-2.7,3
ENSMUSG00000095607,TRAV5-4,T cell receptor alpha variable 5-4,None,None,None,10,3.8,0.716,9,0,0,0,0,0.885,-2,7.2
ENSMUSG00000055301,ADH7,"alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide",extracellular region|cytosol|,retinoid metabolic process|ethanol catabolic process|ethanol oxidation|ethanol oxidation|xenobiotic metabolic process|response to bacterium|fatty acid omega-oxidation|retinol metabolic process|retinoic acid metabolic process|small molecule metabolic process|response to ethanol|oxidation-reduction process|extracellular negative regulation of signal transduction|,"alcohol dehydrogenase (NAD) activity|alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|retinol dehydrogenase activity|zinc ion binding|retinol binding|ethanol binding|receptor antagonist activity|",10,-0.7,0.239,9,0.3,0.259,0,0,0.885,-3.2,2.5
ENSMUSG00000043518,RAI2,retinoic acid induced 2,cellular_component|,embryo development|,molecular_function|protein binding|,9,0,0,9,0,0,0,0,0.885,-3.7,3.6
ENSMUSG00000039086,SS18L1,synovial sarcoma translocation gene on chromosome 18-like 1,"kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|nucleus|nuclear body|","transcription, DNA-templated|dendrite development|chromatin modification|positive regulation of transcription, DNA-templated|regulation of dendrite development|",None,10,-0.1,0.00145,10,0.6,0.494,0,0,0.885,-3.5,2.8
ENSMUSG00000031142,CACNA1F,"calcium channel, voltage-dependent, L type, alpha 1F subunit",photoreceptor outer segment|voltage-gated calcium channel complex|integral component of membrane|perikaryon|,cellular calcium ion homeostasis|axonogenesis|visual perception|regulation of ion transmembrane transport|dendrite morphogenesis|detection of light stimulus involved in visual perception|retina development in camera-type eye|calcium ion import|membrane depolarization during action potential|,voltage-gated calcium channel activity|high voltage-gated calcium channel activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-4.9,3
ENSMUSG00000040945,RCC2,regulator of chromosome condensation 2,"nucleolus|cytosol|microtubule|midbody|chromosome, centromeric core region|mitotic spindle midzone|",mitotic cell cycle|endosome organization|mitotic nuclear division|integrin-mediated signaling pathway|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell migration|negative regulation of GTPase activity|focal adhesion assembly|negative regulation of focal adhesion assembly|positive regulation of attachment of spindle microtubules to kinetochore|chromosome passenger complex localization to kinetochore|negative regulation of substrate adhesion-dependent cell spreading|,protein binding|microtubule binding|poly(A) RNA binding|Rac GTPase binding|,10,0.1,0.00301,10,0,0,0,0,0.885,-1.9,2.3
ENSMUSG00000037386,RIMS2,regulating synaptic membrane exocytosis 2,cell junction|presynaptic membrane|,intracellular protein transport|calcium ion-dependent exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|regulation of membrane potential|calcium ion-dependent exocytosis of neurotransmitter|,protein binding|Rab GTPase binding|ion channel binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-6.1,3.5
ENSMUSG00000028417,TAL2,T-cell acute lymphocytic leukemia 2,None,"transcription, DNA-templated|regulation of transcription, DNA-templated|post-embryonic development|thalamus development|midbrain development|multicellular organism growth|",DNA binding|protein dimerization activity|,10,0,0,10,0,0,0,0,0.885,-3.9,2.5
ENSMUSG00000029591,UNG,uracil-DNA glycosylase,nucleus|mitochondrion|,DNA repair|base-excision repair|viral process|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|negative regulation of apoptotic process|,uracil DNA N-glycosylase activity|,10,0.1,0.00993,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000029095,ABLIM2,"actin binding LIM protein family, member 2",actin cytoskeleton|myofibril|,"transcription, DNA-templated|axon guidance|actin cytoskeleton organization|positive regulation of transcription from RNA polymerase II promoter|",actin binding|zinc ion binding|,10,-1.3,0.32,10,0.2,0.00231,0,0,0.885,-4.8,3
ENSMUSG00000024805,PCGF5,polycomb group ring finger 5,nucleus|nucleolus|centrosome|PcG protein complex|,"transcription, DNA-templated|regulation of transcription, DNA-templated|",protein binding|zinc ion binding|,10,-1.3,0.14,10,0,0,0,0,0.885,-4.9,2.4
ENSMUSG00000036986,PML,promyelocytic leukemia,nucleus|nucleoplasm|nucleoplasm|nucleolus|cytoplasm|cytosol|nuclear matrix|nuclear matrix|PML body|PML body|PML body|early endosome membrane|nuclear membrane|extrinsic component of endoplasmic reticulum membrane|,"response to hypoxia|regulation of protein phosphorylation|positive regulation of defense response to virus by host|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|protein targeting|protein targeting|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|cell cycle arrest|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein import into nucleus|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to UV|response to gamma radiation|regulation of calcium ion transport into cytosol|viral process|negative regulation of angiogenesis|cytokine-mediated signaling pathway|myeloid cell differentiation|negative regulation of cell growth|PML body organization|PML body organization|positive regulation of histone deacetylation|negative regulation of telomere maintenance via telomerase|endoplasmic reticulum calcium ion homeostasis|circadian regulation of gene expression|negative regulation of translation in response to oxidative stress|response to cytokine|regulation of circadian rhythm|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|cell fate commitment|regulation of MHC class I biosynthetic process|negative regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|retinoic acid receptor signaling pathway|protein stabilization|maintenance of protein location in nucleus|defense response to virus|negative regulation of telomerase activity|positive regulation of apoptotic process involved in mammary gland involution|interferon-gamma-mediated signaling pathway|branching involved in mammary gland duct morphogenesis|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to interleukin-4|cellular senescence|extrinsic apoptotic signaling pathway|negative regulation of viral release from host cell|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of double-strand break repair|positive regulation of extrinsic apoptotic signaling pathway|",DNA binding|transcription coactivator activity|protein binding|zinc ion binding|zinc ion binding|ubiquitin protein ligase binding|SUMO binding|protein homodimerization activity|SMAD binding|protein heterodimerization activity|cobalt ion binding|,10,0,0,10,0,0,0,0,0.885,-4.3,2
ENSMUSG00000037035,INHBB,"inhibin, beta B",extracellular region|perinuclear region of cytoplasm|,ovarian follicle development|defense response|cellular response to starvation|response to mechanical stimulus|cell differentiation|cellular response to insulin stimulus|activin receptor signaling pathway|growth|cellular response to leptin stimulus|fat cell differentiation|negative regulation of insulin secretion|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|oocyte development|positive regulation of ovulation|positive regulation of apoptotic signaling pathway|,cytokine activity|hormone activity|protein binding|growth factor activity|protein homodimerization activity|host cell surface receptor binding|,10,0.3,0.108,10,-0.8,0.325,0,0,0.885,-5.1,5.1
ENSMUSG00000030513,PCSK6,proprotein convertase subtilisin/kexin type 6,extracellular space|endoplasmic reticulum|Golgi lumen|cell surface|membrane|extracellular matrix|,"proteolysis|zygotic determination of anterior/posterior axis, embryo|determination of left/right symmetry|glycoprotein metabolic process|protein processing|peptide hormone processing|regulation of BMP signaling pathway|nerve growth factor processing|nerve growth factor production|secretion by cell|neurotrophin TRK receptor signaling pathway|",endopeptidase activity|serine-type endopeptidase activity|heparin binding|nerve growth factor binding|,10,0,0,10,-0.2,0.0478,0,0,0.885,-2.8,2.1
ENSMUSG00000002227,MOV10,Mov10 RISC complex RNA helicase,cytoplasmic mRNA processing body|extracellular space|cytosol|,"transcription, DNA-templated|regulation of transcription, DNA-templated|epidermal growth factor receptor signaling pathway|Notch signaling pathway|fibroblast growth factor receptor signaling pathway|mRNA cleavage involved in gene silencing by miRNA|Fc-epsilon receptor signaling pathway|innate immune response|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|",helicase activity|protein binding|ATP binding|poly(A) RNA binding|,1,0,0,0,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000042115,KLHDC8A,kelch domain containing 8A,None,None,None,10,0,0,10,-0.6,0.139,0,0,0.885,-2,1.3
ENSMUSG00000022376,ADCY8,adenylate cyclase 8 (brain),plasma membrane|membrane|integral component of membrane|,energy reserve metabolic process|cAMP biosynthetic process|water transport|signal transduction|epidermal growth factor receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|activation of phospholipase C activity|synaptic transmission|learning or memory|long-term memory|fibroblast growth factor receptor signaling pathway|activation of protein kinase A activity|intracellular signal transduction|small molecule metabolic process|innate immune response|neurotrophin TRK receptor signaling pathway|transmembrane transport|cellular response to glucagon stimulus|,adenylate cyclase activity|ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding|,9,-0.2,0.0411,9,0.4,0.265,0,0,0.885,-4.3,3
ENSMUSG00000020581,AGR2,anterior gradient 2,extracellular region|mitochondrion|endoplasmic reticulum|,lung goblet cell differentiation|mucus secretion|,dystroglycan binding|protein binding|,10,0,0,10,0,0,0,0,0.885,-7.9,2.8
ENSMUSG00000001157,GMCL1,"germ cell-less, spermatogenesis associated 1",nuclear envelope|nuclear matrix|,"regulation of transcription, DNA-templated|multicellular organismal development|spermatogenesis|cell differentiation|",None,10,0,0,10,0,0,0,0,0.885,-8.2,2.9
ENSMUSG00000036106,PRR5,proline rich 5 (renal),TORC2 complex|,positive regulation of protein phosphorylation|cell cycle|positive regulation of phosphatidylinositol 3-kinase signaling|,None,10,0,0,10,0.1,0.0202,0,0,0.885,-4.7,4
ENSMUSG00000034957,CEBPA,"CCAAT/enhancer binding protein (C/EBP), alpha",nucleus|nuclear matrix|Rb-E2F complex|,"urea cycle|negative regulation of transcription from RNA polymerase II promoter|liver development|embryonic placenta development|generation of precursor metabolites and energy|transcription, DNA-templated|transcription, DNA-templated|transcription from RNA polymerase II promoter|acute-phase response|mitochondrion organization|cholesterol metabolic process|negative regulation of cell proliferation|viral process|cytokine-mediated signaling pathway|myeloid cell differentiation|macrophage differentiation|lung development|organ regeneration|response to vitamin B2|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|cell maturation|inner ear development|white fat cell differentiation|brown fat cell differentiation|response to glucocorticoid|cellular response to lithium ion|cellular response to organic cyclic compound|",DNA binding|sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|protein complex binding|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|protein heterodimerization activity|HMG box domain binding|,10,0,0,10,0,0,0,0,0.885,-2,2.7
ENSMUSG00000004939,NMRK2,nicotinamide riboside kinase 2,intracellular|,NAD biosynthetic process|phosphorylation|negative regulation of myoblast differentiation|,protein binding|ATP binding|metal ion binding|ribosylnicotinamide kinase activity|,10,4.2,0.25,10,0,0,0,0,0.885,-3,7.8
ENSMUSG00000026837,COL5A1,"collagen, type V, alpha 1",extracellular region|collagen type V trimer|basement membrane|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|extracellular vesicular exosome|,"blood vessel development|heart morphogenesis|cell adhesion|axon guidance|cell migration|extracellular matrix disassembly|extracellular matrix organization|collagen fibril organization|collagen fibril organization|collagen catabolic process|collagen biosynthetic process|wound healing, spreading of epidermal cells|tendon development|extracellular fibril organization|skin development|integrin biosynthetic process|eye morphogenesis|regulation of cellular component organization|",integrin binding|extracellular matrix structural constituent|heparin binding|proteoglycan binding|metal ion binding|platelet-derived growth factor binding|,10,0,0,10,0.9,0.504,0,0,0.885,-2.5,3
ENSMUSG00000067878,MTAP7D3,MAP7 domain containing 3,nucleus|cytoplasm|centrosome|cytoskeleton|microtubule|membrane|,microtubule cytoskeleton organization|biological_process|,molecular_function|,10,0,0,10,0,0,0,0,0.885,-3.9,3.3
ENSMUSG00000048922,CDCA2,cell division cycle associated 2,nucleus|chromosome|cytoplasm|,mitotic nuclear division|positive regulation of protein dephosphorylation|,None,10,0,0,9,-0.4,0.156,0,0,0.885,-3.8,5.2
ENSMUSG00000038567,CYP24A1,"cytochrome P450, family 24, subfamily A, polypeptide 1",mitochondrial inner membrane|,osteoblast differentiation|vitamin metabolic process|xenobiotic metabolic process|steroid metabolic process|response to vitamin D|vitamin D metabolic process|vitamin D catabolic process|small molecule metabolic process|oxidation-reduction process|vitamin D receptor signaling pathway|,"iron ion binding|25-hydroxycholecalciferol-24-hydroxylase activity|oxidoreductase activity|heme binding|1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|",10,0,0,10,0,0,0,0,0.885,-7.4,2
ENSMUSG00000001604,TCEA3,"transcription elongation factor A (SII), 3",nucleus|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|",DNA binding|zinc ion binding|,9,-0.1,0.00273,9,0,0,0,0,0.885,-4.2,3.2
ENSMUSG00000023755,RHEBL1,Ras homolog enriched in brain like 1,cytoplasm|plasma membrane|,GTP catabolic process|small GTPase mediated signal transduction|TOR signaling|positive regulation of NF-kappaB transcription factor activity|,GTP binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000028796,PHC2,polyhomeotic homolog 2 (Drosophila),nucleus|nucleoplasm|PcG protein complex|PRC1 complex|,multicellular organismal development|spermatogenesis|,DNA binding|protein binding|zinc ion binding|,10,-0.6,0.0654,10,0,0,0,0,0.885,-4.6,3.9
ENSMUSG00000022219,CIDEB,cell death-inducing DFFA-like effector b,lipid particle|cytosol|,apoptotic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of apoptotic process|execution phase of apoptosis|,protein binding|identical protein binding|,10,0,0,10,0,0,0,0,0.885,-3.2,2.5
ENSMUSG00000040462,OS9,"osteosarcoma amplified 9, endoplasmic reticulum lectin",Hrd1p ubiquitin ligase complex|endoplasmic reticulum lumen|,protein targeting|protein retention in ER lumen|protein ubiquitination|ER-associated ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|,glycoprotein binding|protease binding|protein binding|,1,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000002603,TGFB1,"transforming growth factor, beta 1",extracellular region|proteinaceous extracellular matrix|extracellular space|nucleus|cytoplasm|Golgi lumen|plasma membrane|microvillus|cell surface|axon|platelet alpha granule lumen|neuronal cell body|blood microparticle|,"protein import into nucleus, translocation|negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|ureteric bud development|response to hypoxia|epithelial to mesenchymal transition|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of sodium ion transport|chondrocyte differentiation|hematopoietic progenitor cell differentiation|connective tissue replacement involved in inflammatory response wound healing|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|tolerance induction to self antigen|platelet degranulation|protein phosphorylation|protein export from nucleus|ATP biosynthetic process|phosphate-containing compound metabolic process|cellular calcium ion homeostasis|inflammatory response|cell cycle arrest|mitotic cell cycle checkpoint|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|SMAD protein import into nucleus|negative regulation of neuroblast proliferation|salivary gland morphogenesis|endoderm development|female pregnancy|aging|blood coagulation|negative regulation of DNA replication|positive regulation of cell proliferation|negative regulation of cell proliferation|germ cell migration|response to radiation|response to wounding|response to glucose|embryo development|defense response to fungus, incompatible interaction|positive regulation vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|negative regulation of extracellular matrix disassembly|positive regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|macrophage derived foam cell differentiation|positive regulation of fibroblast migration|positive regulation of peptidyl-threonine phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|cell growth|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|modulation by virus of host morphology or physiology|evasion or tolerance of host defenses by virus|viral life cycle|negative regulation of cell-cell adhesion|platelet activation|extracellular matrix organization|hyaluronan catabolic process|negative regulation of ossification|negative regulation of cell growth|regulation of cell migration|positive regulation of cell migration|positive regulation of bone mineralization|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of histone deacetylation|organ regeneration|positive regulation of protein complex assembly|positive regulation of exit from mitosis|lipopolysaccharide-mediated signaling pathway|positive regulation of cellular protein metabolic process|response to estradiol|response to progesterone|positive regulation of interleukin-17 production|receptor catabolic process|positive regulation of superoxide anion generation|mononuclear cell proliferation|positive regulation of collagen biosynthetic process|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|response to vitamin D|response to laminar fluid shear stress|positive regulation of histone acetylation|positive regulation of protein dephosphorylation|negative regulation of T cell proliferation|regulation of protein import into nucleus|positive regulation of protein import into nucleus|positive regulation of odontogenesis|response to drug|myelination|myeloid dendritic cell differentiation|T cell homeostasis|positive regulation of apoptotic process|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|ossification involved in bone remodeling|regulatory T cell differentiation|cell-cell junction organization|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|active induction of host immune response by virus|positive regulation of isotype switching to IgA isotypes|lymph node development|digestive tract development|negative regulation of skeletal muscle tissue development|inner ear development|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|negative regulation of phagocytosis|negative regulation of immune response|positive regulation of chemotaxis|positive regulation of NF-kappaB transcription factor activity|regulation of binding|regulation of DNA binding|positive regulation of smooth muscle cell differentiation|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of cell division|positive regulation of protein kinase B signaling|regulation of blood vessel remodeling|face morphogenesis|frontal suture morphogenesis|pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|mammary gland branching involved in thelarche|branch elongation involved in mammary gland duct branching|regulation of branching involved in mammary gland duct morphogenesis|regulation of cartilage development|lens fiber cell differentiation|response to cholesterol|positive regulation of cell cycle arrest|cellular response to organic cyclic compound|cellular response to dexamethasone stimulus|cellular response to transforming growth factor beta stimulus|extracellular matrix assembly|positive regulation of branching involved in ureteric bud morphogenesis|extrinsic apoptotic signaling pathway|negative regulation of hyaluronan biosynthetic process|positive regulation of extracellular matrix assembly|positive regulation of NAD+ ADP-ribosyltransferase activity|regulation of miRNA metabolic process|positive regulation of transcription regulatory region DNA binding|",glycoprotein binding|antigen binding|type II transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding|cytokine activity|protein binding|growth factor activity|enzyme binding|protein homodimerization activity|protein heterodimerization activity|protein N-terminus binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.8
ENSMUSG00000038539,ATF5,activating transcription factor 5,nucleus|transcription factor complex|cytoplasm|,"transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|post-embryonic development|olfactory bulb interneuron development|multicellular organism growth|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|negative regulation of astrocyte differentiation|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription corepressor activity|protein binding|heat shock protein binding|,9,0,0,8,0,0,0,0,0.885,-3.1,3.5
ENSMUSG00000028709,MOB3C,MOB kinase activator 3C,None,None,metal ion binding|,10,0.3,0.059,10,0,0,0,0,0.885,-3.1,3.3
ENSMUSG00000091971,HSPA1A,heat shock 70kDa protein 1A,None,None,None,10,0,0,10,0,0,0,0,0.885,-6.5,2
ENSMUSG00000003072,ATP5D,"ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit","mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|",oxidative phosphorylation|ATP catabolic process|ATP biosynthetic process|respiratory electron transport chain|mitochondrial ATP synthesis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|cellular metabolic process|small molecule metabolic process|response to copper ion|,"transporter activity|ATP binding|ATPase activity|transmembrane transporter activity|ADP binding|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|",10,-1.2,0.503,10,0,0,0,0,0.885,-4.5,8.9
ENSMUSG00000020263,APPL2,"adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2",nucleus|cytoplasm|endosome membrane|NuRD complex|early endosome membrane|extracellular vesicular exosome|,cell cycle|signal transduction|cell proliferation|,protein binding|,10,-1.4,1.07,10,0,0,0,0,0.885,-6.6,3.4
ENSMUSG00000021048,MTHFD1,"methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase",mitochondrion|cytosol|cytosol|membrane|extracellular vesicular exosome|,histidine biosynthetic process|purine nucleotide biosynthetic process|one-carbon metabolic process|vitamin metabolic process|water-soluble vitamin metabolic process|methionine biosynthetic process|folic acid-containing compound biosynthetic process|tetrahydrofolate interconversion|small molecule metabolic process|folic acid metabolic process|oxidation-reduction process|,formate-tetrahydrofolate ligase activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|,10,0,0,10,0,0,0,0,0.885,-2.6,2.4
ENSMUSG00000068036,MLLT4,"myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4",nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|cell-cell adherens junction|cell junction|apical part of cell|,cell adhesion|signal transduction|cell-cell signaling|cell junction assembly|adherens junction organization|cell-cell junction organization|,protein binding|protein C-terminus binding|cell adhesion molecule binding|,10,0,0,10,0.5,0.243,0,0,0.885,-2,4.4
ENSMUSG00000049811,FAM161A,"family with sequence similarity 161, member A",cytoplasm|centrosome|photoreceptor connecting cilium|ciliary basal body|,visual perception|cilium assembly|response to stimulus|,protein binding|,10,-0.1,0.0147,10,0,0,0,0,0.885,-6.1,2
ENSMUSG00000040151,HS2ST1,heparan sulfate 2-O-sulfotransferase 1,Golgi membrane|membrane|integral component of membrane|,carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosaminoglycan metabolic process|small molecule metabolic process|,sulfotransferase activity|,10,0,0,10,-0.1,0.00812,0,0,0.885,-7.7,3.1
ENSMUSG00000031803,B3GNT3,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3",Golgi membrane|integral component of plasma membrane|,carbohydrate metabolic process|O-glycan processing|keratan sulfate biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate metabolic process|post-translational protein modification|cellular protein metabolic process|small molecule metabolic process|,"galactosyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|",10,-1.8,0.642,10,0.1,0.00824,0,0,0.885,-4,2.5
ENSMUSG00000024193,PHF1,PHD finger protein 1,nucleus|cytoplasm|microtubule organizing center|ESC/E(Z) complex|site of double-strand break|,"transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|chromatin modification|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|",sequence-specific DNA binding transcription factor activity|zinc ion binding|methylated histone binding|,10,0,0,10,0,0,0,0,0.885,-7,2.5
ENSMUSG00000073491,PYDC4,pyrin domain containing 4,nucleus|nucleolus|cytoplasm|membrane|,biological_process|,double-stranded DNA binding|transcription factor binding|poly(A) RNA binding|,10,0,0,10,0,0,0,0,0.885,-2.4,2.5
ENSMUSG00000032688,MALT1,mucosa associated lymphoid tissue lymphoma translocation gene 1,nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|CBM complex|protein complex|perinuclear region of cytoplasm|,B-1 B cell differentiation|response to molecule of bacterial origin|positive regulation of T cell cytokine production|proteolysis|defense response|activation of NF-kappaB-inducing kinase activity|response to fungus|protein ubiquitination|positive regulation of protein ubiquitination|positive regulation of interleukin-2 production|Fc-epsilon receptor signaling pathway|T cell proliferation|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|T cell receptor signaling pathway|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of T cell activation|positive regulation of NF-kappaB transcription factor activity|nuclear export|protein oligomerization|,protease binding|cysteine-type endopeptidase activity|ubiquitin-protein transferase activity|signal transducer activity|protein binding|peptidase activity|kinase activator activity|protein self-association|,10,0,0,10,0,0,0,0,0.885,-7.2,4
ENSMUSG00000032908,SGPP2,sphingosine-1-phosphate phosphatase 2,endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|,sphingolipid metabolic process|sphingosine metabolic process|dephosphorylation|sphingolipid biosynthetic process|small molecule metabolic process|,sphingosine-1-phosphate phosphatase activity|,10,0,0,10,0,0,0,0,0.885,-7.5,3
ENSMUSG00000018377,VEZF1,vascular endothelial zinc finger 1,nucleus|,angiogenesis|endothelial cell development|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cellular defense response|,DNA binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000015745,PLEKHO1,"pleckstrin homology domain containing, family O member 1",nucleus|cytoplasm|plasma membrane|,None,protein binding|,10,0,0,10,-2.5,0.395,0,0,0.885,-6.6,4.6
ENSMUSG00000039062,ANPEP,alanyl (membrane) aminopeptidase,extracellular space|lysosomal membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|integral component of plasma membrane|external side of plasma membrane|extracellular vesicular exosome|,angiogenesis|angiotensin maturation|proteolysis|response to virus|viral process|cell differentiation|cellular protein metabolic process|,virus receptor activity|aminopeptidase activity|receptor activity|metallopeptidase activity|zinc ion binding|,10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000021461,FANCC,"Fanconi anemia, complementation group C",nucleus|nucleoplasm|cytoplasm|cytosol|Fanconi anaemia nuclear complex|,myeloid cell homeostasis|DNA repair|nucleotide-excision repair|protein complex assembly|germ cell development|removal of superoxide radicals|,protein binding|,10,0.5,0.279,10,-0.1,0.0254,0,0,0.885,-7.8,4.8
ENSMUSG00000031273,COL4A6,"collagen, type IV, alpha 6",extracellular region|collagen type IV trimer|endoplasmic reticulum lumen|,cell adhesion|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|cellular response to amino acid stimulus|,extracellular matrix structural constituent|,10,0,0,10,0,0,0,0,0.885,-3,2.7
ENSMUSG00000004267,ENO2,"enolase 2 (gamma, neuronal)",phosphopyruvate hydratase complex|photoreceptor inner segment|extracellular space|cytosol|plasma membrane|perikaryon|extracellular vesicular exosome|,carbohydrate metabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|glycolytic process|small molecule metabolic process|,magnesium ion binding|phosphopyruvate hydratase activity|,10,-0.7,0.175,10,0,0,0,0,0.885,-2.8,2.1
ENSMUSG00000021244,YLPM1,YLP motif containing 1,nucleus|nuclear speck|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|biological_process|regulation of telomere maintenance|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|protein binding|poly(A) RNA binding|,9,-0.9,0.442,9,0.3,0.0297,0,0,0.885,-7.8,4
ENSMUSG00000018983,E2F2,E2F transcription factor 2,nucleoplasm|transcription factor complex|,"mitotic cell cycle|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|regulation of cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|lens fiber cell apoptotic process|",core promoter binding|DNA binding|sequence-specific DNA binding transcription factor activity|protein binding|transcription factor binding|,10,0.4,0.198,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000020520,GALNT10,polypeptide N-acetylgalactosaminyltransferase 10,Golgi membrane|integral component of membrane|,O-glycan processing|post-translational protein modification|cellular protein metabolic process|,polypeptide N-acetylgalactosaminyltransferase activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-1.9,1.5
ENSMUSG00000024985,TCF7L2,"transcription factor 7-like 2 (T-cell specific, HMG-box)",nuclear chromatin|nucleus|nucleoplasm|nucleoplasm|transcription factor complex|cytoplasm|PML body|protein-DNA complex|beta-catenin-TCF7L2 complex|,"negative regulation of transcription from RNA polymerase II promoter|blood vessel development|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell cycle arrest|brain development|cell proliferation|response to glucose|positive regulation of heparan sulfate proteoglycan biosynthetic process|oligodendrocyte development|neural tube development|pituitary gland development|bone mineralization|negative regulation of BMP signaling pathway|embryonic genitalia morphogenesis|pancreas development|regulation of myelination|positive regulation of insulin secretion|positive regulation of insulin secretion|positive regulation of protein binding|secretory granule localization|regulation of hormone metabolic process|somatic stem cell maintenance|catenin import into nucleus|negative regulation of fibroblast growth factor receptor signaling pathway|odontogenesis of dentin-containing tooth|glucose homeostasis|positive regulation of apoptotic process|negative regulation of sequence-specific DNA binding transcription factor activity|maintenance of DNA repeat elements|skin development|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|fat cell differentiation|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of organ growth|positive regulation of protein export from nucleus|embryonic digestive tract morphogenesis|embryonic hindgut morphogenesis|myoblast fate commitment|regulation of skeletal muscle tissue development|regulation of smooth muscle cell proliferation|generation of neurons|regulation of oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|canonical Wnt signaling pathway|face morphogenesis|regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of canonical Wnt signaling pathway|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|chromatin binding|sequence-specific DNA binding transcription factor activity|protein binding|beta-catenin binding|beta-catenin binding|transcription factor binding|protein kinase binding|nuclear hormone receptor binding|sequence-specific DNA binding|sequence-specific DNA binding|transcription regulatory region DNA binding|gamma-catenin binding|armadillo repeat domain binding|,10,0,0,10,0,0,0,0,0.885,-2,2.7
ENSMUSG00000038210,HOXA11,homeobox A11,nucleus|transcription factor complex|protein-DNA complex|protein complex|,"skeletal system development|metanephros development|branching involved in ureteric bud morphogenesis|organ induction|transcription, DNA-templated|multicellular organismal development|mesodermal cell fate specification|anatomical structure morphogenesis|anterior/posterior pattern specification|dorsal/ventral pattern formation|proximal/distal pattern formation|positive regulation of cell development|embryonic limb morphogenesis|positive regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|embryonic digit morphogenesis|positive regulation of transcription, DNA-templated|developmental growth|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|",sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|,10,0,0,10,-0.6,0.135,0,0,0.885,-4.7,6.6
ENSMUSG00000010054,TUSC2,tumor suppressor candidate 2,mitochondrion|,natural killer cell differentiation|inflammatory response|cell cycle|cell-cell signaling|cell proliferation|interleukin-15 production|cell maturation|regulation of mitochondrial membrane potential|chemokine (C-C motif) ligand 5 production|regulation of reactive oxygen species metabolic process|,None,9,0,0,9,-0.1,0.00176,0,0,0.885,-3.4,2.3
ENSMUSG00000053519,KCNIP1,Kv channel interacting protein 1,plasma membrane|dendrite|potassium channel complex|neuronal cell body|,detection of calcium ion|signal transduction|synaptic transmission|regulation of ion transmembrane transport|positive regulation of action potential|potassium ion transmembrane transport|,voltage-gated ion channel activity|potassium channel activity|calcium ion binding|protein binding|potassium channel regulator activity|ion channel binding|protein heterodimerization activity|protein N-terminus binding|,10,0,0,10,0,0,0,0,0.885,-1.9,2.2
ENSMUSG00000007458,M6PR,mannose-6-phosphate receptor (cation dependent),lysosomal membrane|endosome|late endosome|integral component of plasma membrane|membrane|,receptor-mediated endocytosis|signal transduction|endosome to lysosome transport|mannose transport|,transmembrane signaling receptor activity|mannose binding|mannose transmembrane transporter activity|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000072919,NOXRED1,NADP-dependent oxidoreductase domain containing 1,cellular_component|,proline biosynthetic process|biological_process|oxidation-reduction process|,molecular_function|pyrroline-5-carboxylate reductase activity|,10,0.5,0.267,10,0,0,0,0,0.885,-6.9,4
ENSMUSG00000035637,GRHPR,glyoxylate reductase/hydroxypyruvate reductase,cytoplasm|peroxisomal matrix|cytosol|extracellular vesicular exosome|,excretion|metabolic process|cellular nitrogen compound metabolic process|dicarboxylic acid metabolic process|small molecule metabolic process|glyoxylate metabolic process|protein oligomerization|oxidation-reduction process|,glycerate dehydrogenase activity|hydroxypyruvate reductase activity|glyoxylate reductase (NADP) activity|glyoxylate reductase (NADP) activity|carboxylic acid binding|protein homodimerization activity|NAD binding|NADPH binding|,10,0,0,10,0,0,0,0,0.885,-2.8,2.9
ENSMUSG00000049401,OGFR,opioid growth factor receptor,cellular_component|nucleus|cytoplasm|membrane|,regulation of cell growth|opioid receptor signaling pathway|,opioid receptor activity|,10,0,0,10,4.3,0.766,0,0,0.885,-3.4,8.1
ENSMUSG00000015468,NOTCH4,notch 4,Golgi membrane|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|cell surface|,"patterning of blood vessels|cell fate determination|morphogenesis of a branching structure|endothelial cell morphogenesis|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|Notch receptor processing|positive regulation of transcription of Notch receptor target|embryo development|gene expression|hemopoiesis|cell differentiation|mammary gland development|negative regulation of cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of transcription, DNA-templated|",receptor activity|calcium ion binding|protein binding|protein heterodimerization activity|,10,0,0,10,0,0,0,0,0.885,-6.8,4.5
ENSMUSG00000000290,ITGB2,"integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)",plasma membrane|integrin complex|cell surface|membrane|receptor complex|extracellular vesicular exosome|,toll-like receptor signaling pathway|apoptotic process|inflammatory response|cell adhesion|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|cell-cell signaling|multicellular organismal development|blood coagulation|regulation of cell shape|extracellular matrix organization|neutrophil chemotaxis|toll-like receptor 4 signaling pathway|innate immune response|regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|leukocyte migration|,glycoprotein binding|receptor activity|protein binding|protein kinase binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.8,3.7
ENSMUSG00000039298,CDK5RAP2,CDK5 regulatory subunit associated protein 2,pericentriolar material|spindle pole|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton|microtubule|cell junction|perinuclear region of cytoplasm|extracellular vesicular exosome|,"G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|mitotic cell cycle|microtubule bundle formation|chromosome segregation|brain development|brain development|neurogenesis|regulation of neuron differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|centrosome organization|regulation of spindle checkpoint|",protein binding|calmodulin binding|microtubule binding|tubulin binding|protein kinase binding|transcription regulatory region DNA binding|,10,0,0,10,1.6,0.117,0,0,0.885,-6,8
ENSMUSG00000029209,GNPDA2,glucosamine-6-phosphate deaminase 2,nucleus|cytoplasm|,carbohydrate metabolic process|N-acetylglucosamine metabolic process|,glucosamine-6-phosphate deaminase activity|hydrolase activity|,9,1.1,0.516,10,-1.9,0.753,0,0,0.885,-6.4,3.8
ENSMUSG00000068580,ZFYVE19,"zinc finger, FYVE domain containing 19",cytoplasm|centrosome|midbody|cleavage furrow|,abscission|cytokinesis checkpoint|negative regulation of cytokinesis|cell division|,protein binding|zinc ion binding|phosphatidylinositol-3-phosphate binding|,10,-0.5,0.187,10,0.2,0.0382,0,0,0.885,-5.1,2
ENSMUSG00000078773,RAD54B,RAD54 homolog B (S. cerevisiae),nucleus|,double-strand break repair via homologous recombination|ATP catabolic process|mitotic recombination|reciprocal meiotic recombination|DNA duplex unwinding|,DNA binding|DNA helicase activity|RNA helicase activity|ATP binding|DNA translocase activity|,10,-1,0.559,10,0.3,0.192,0,0,0.885,-8.9,3.8
ENSMUSG00000021120,PIGH,"phosphatidylinositol glycan anchor biosynthesis, class H",glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum|endoplasmic reticulum membrane|,cellular protein modification process|C-terminal protein lipidation|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|post-translational protein modification|cellular protein metabolic process|,catalytic activity|phosphatidylinositol N-acetylglucosaminyltransferase activity|,10,0.9,0.877,10,0,0,0,0,0.885,-1.9,3.7
ENSMUSG00000047832,CDCA4,cell division cycle associated 4,nucleus|,None,protein binding|,0,0,0,1,0,0,0,0,0.885,-1.8,2
ENSMUSG00000036585,FGF1,fibroblast growth factor 1 (acidic),extracellular region|extracellular region|proteinaceous extracellular matrix|extracellular space|nucleus|cytosol|cell cortex|,angiogenesis|organ induction|positive regulation of protein phosphorylation|signal transduction|epidermal growth factor receptor signaling pathway|multicellular organismal development|positive regulation of cell proliferation|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|anatomical structure morphogenesis|lung development|positive regulation of cell migration|cellular response to heat|Fc-epsilon receptor signaling pathway|innate immune response|positive regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of epithelial cell proliferation|positive regulation of cell division|branch elongation involved in ureteric bud branching|mesonephric epithelium development|positive regulation of intracellular signal transduction|,fibroblast growth factor receptor binding|protein binding|growth factor activity|heparin binding|Hsp70 protein binding|S100 protein binding|,10,0,0,10,0.5,0.0864,0,0,0.885,-4.9,3.7
ENSMUSG00000044502,BOD1,biorientation of chromosomes in cell division 1,condensed chromosome kinetochore|cytoplasm|microtubule organizing center|,mitotic nuclear division|,None,10,0.3,0.0238,10,0,0,0,0,0.885,-2,3.5
ENSMUSG00000036478,BTG1,"B-cell translocation gene 1, anti-proliferative",nucleus|nucleus|cytoplasm|cytoplasm|,"regulation of transcription, DNA-templated|negative regulation of cell proliferation|cell migration|negative regulation of cell growth|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|positive regulation of myoblast differentiation|positive regulation of angiogenesis|positive regulation of fibroblast apoptotic process|",transcription cofactor activity|protein binding|enzyme binding|kinase binding|,10,-0.5,0.203,10,0,0,0,0,0.885,-4.5,4.2
ENSMUSG00000037373,CTBP1,C-terminal binding protein 1,nucleus|nucleus|transcription factor complex|cytosol|transcriptional repressor complex|transcriptional repressor complex|,"negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|protein phosphorylation|Golgi organization|negative regulation of cell proliferation|viral genome replication|positive regulation of histone deacetylation|regulation of transcription by chromatin organization|negative regulation of histone acetylation|negative regulation of transcription, DNA-templated|white fat cell differentiation|regulation of cell cycle|oxidation-reduction process|negative regulation of histone H4 acetylation|","RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity|protein binding|protein C-terminus binding|transcription factor binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein domain specific binding|protein domain specific binding|protein homodimerization activity|NAD binding|repressing transcription factor binding|",10,-1.2,0.285,10,0,0,0,0,0.885,-4.8,3.1
ENSMUSG00000031156,SLC35A2,"solute carrier family 35 (UDP-galactose transporter), member A2",Golgi membrane|nucleus|Golgi apparatus|integral component of membrane|,galactose metabolic process|UDP-galactose transport|proton transport|transmembrane transport|UDP-galactose transmembrane transport|,sugar:proton symporter activity|UDP-galactose transmembrane transporter activity|protein binding|,10,0,0,10,-0.2,0.0451,0,0,0.885,-4.2,3.8
ENSMUSG00000020849,YWHAE,"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon",mitochondrion|cytosol|kinesin complex|membrane|cytoplasmic vesicle membrane|melanosome|extracellular vesicular exosome|,G2/M transition of mitotic cell cycle|mitotic cell cycle|neuron migration|regulation of heart rate by hormone|protein targeting|apoptotic process|viral process|substantia nigra development|hippocampus development|cerebral cortex development|hippo signaling|intracellular signal transduction|regulation of cysteine-type endopeptidase activity involved in apoptotic process|neurotrophin TRK receptor signaling pathway|regulation of membrane repolarization|membrane organization|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of potassium ion transmembrane transporter activity|negative regulation of peptidyl-serine dephosphorylation|,protein binding|potassium channel regulator activity|enzyme binding|protein domain specific binding|MHC class II protein complex binding|histone deacetylase binding|ion channel binding|poly(A) RNA binding|protein heterodimerization activity|phosphoserine binding|phosphoprotein binding|,10,1.2,0.737,10,-0.1,0.00842,0,0,0.885,-7.1,5.2
ENSMUSG00000022542,12-Sep,septin 12,stress fiber|spindle|microtubule cytoskeleton|midbody|septin complex|cleavage furrow|perinuclear region of cytoplasm|sperm annulus|,cell cycle|cell division|,protein binding|GTP binding|GTP binding|GDP binding|phosphatidylinositol binding|protein homodimerization activity|protein homodimerization activity|,10,0,0,10,0,0,0,0,0.885,-2.7,2.3
ENSMUSG00000044894,UQCRQ,"ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa",mitochondrion|mitochondrial inner membrane|respiratory chain|,subthalamus development|pons development|cerebellar Purkinje cell layer development|hippocampus development|thalamus development|hypothalamus development|pyramidal neuron development|respiratory electron transport chain|midbrain development|cellular metabolic process|small molecule metabolic process|hydrogen ion transmembrane transport|,ubiquinol-cytochrome-c reductase activity|,10,0.2,0.133,10,0,0,0,0,0.885,-3.1,2.5
ENSMUSG00000009293,UBE2G2,ubiquitin-conjugating enzyme E2G 2,endoplasmic reticulum|cytosol|,ubiquitin-dependent protein catabolic process|protein N-linked glycosylation via asparagine|ER-associated ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|,ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|,10,0.7,0.476,10,-0.9,0.493,0,0,0.885,-4.6,3.2
ENSMUSG00000025147,MOB2,MOB kinase activator 2,nucleus|nucleolus|cytoplasm|neuron projection terminus|perinuclear region of cytoplasm|,positive regulation of protein phosphorylation|positive regulation of neuron projection development|actin cytoskeleton organization|,metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.6,2.3
ENSMUSG00000059305,VPREB1,pre-B lymphocyte 1,None,None,None,9,0.2,0.0118,9,0,0,0,0,0.885,-2.7,3
ENSMUSG00000032171,PIN1,"peptidylprolyl cis/trans isomerase, NIMA-interacting 1",nucleus|nucleoplasm|cytoplasm|nuclear speck|midbody|,protein peptidyl-prolyl isomerization|protein peptidyl-prolyl isomerization|positive regulation of protein phosphorylation|protein folding|cell cycle|regulation of mitosis|cytokine-mediated signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of Rho GTPase activity|regulation of cytokinesis|regulation of cytokinesis|negative regulation of type I interferon production|innate immune response|positive regulation of ubiquitin-protein transferase activity|regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of ERK1 and ERK2 cascade|negative regulation of cell motility|,peptidyl-prolyl cis-trans isomerase activity|protein binding|mitogen-activated protein kinase kinase binding|GTPase activating protein binding|phosphoserine binding|phosphothreonine binding|phosphothreonine binding|,10,-1.7,0.0271,10,0,0,0,0,0.885,-4.3,2.2
ENSMUSG00000054509,PARP4,"poly (ADP-ribose) polymerase family, member 4",nucleus|cytoplasm|spindle microtubule|membrane|ribonucleoprotein complex|extracellular vesicular exosome|,DNA repair|cellular protein modification process|protein ADP-ribosylation|transport|inflammatory response|cellular response to DNA damage stimulus|cell death|response to drug|,DNA binding|NAD+ ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|protein binding|enzyme binding|,10,-0.7,0.413,10,0,0,0,0,0.885,-6.3,1.9
ENSMUSG00000019971,CEP290,centrosomal protein 290kDa,gamma-tubulin complex|nucleus|cytoplasm|centrosome|cytosol|cytosol|membrane|photoreceptor connecting cilium|centriolar satellite|TCTN-B9D complex|protein complex|,"G2/M transition of mitotic cell cycle|mitotic cell cycle|establishment or maintenance of cell polarity|protein transport|regulation of cAMP metabolic process|hindbrain development|otic vesicle formation|cilium assembly|eye photoreceptor cell development|positive regulation of transcription, DNA-templated|pronephros development|retina development in camera-type eye|cilium morphogenesis|regulation of establishment of protein localization|positive regulation of intracellular protein transport|",protein binding|,10,0,0,10,0.3,0.0573,0,0,0.885,-3.3,9.4
ENSMUSG00000073530,PAPPA2,pappalysin 2,extracellular region|intracellular|membrane|extracellular vesicular exosome|,regulation of cell growth|proteolysis|cell differentiation|cellular protein metabolic process|,metallopeptidase activity|zinc ion binding|,10,-0.1,0.00722,10,0.5,0.33,0,0,0.885,-3.3,3
ENSMUSG00000028599,TNFRSF1B,"tumor necrosis factor receptor superfamily, member 1B",extracellular region|nucleus|plasma membrane|integral component of membrane|neuronal cell body|varicosity|membrane raft|perinuclear region of cytoplasm|,inflammatory response|immune response|aging|intrinsic apoptotic signaling pathway in response to DNA damage|tumor necrosis factor-mediated signaling pathway|negative regulation of inflammatory response|RNA destabilization|positive regulation of membrane protein ectodomain proteolysis|cellular response to lipopolysaccharide|cellular response to growth factor stimulus|,tumor necrosis factor-activated receptor activity|protein binding|ubiquitin protein ligase binding|,10,0.2,0.0347,10,0,0,0,0,0.885,-5.3,2
ENSMUSG00000048109,RBM15,RNA binding motif protein 15,nucleus|nuclear membrane|,patterning of blood vessels|positive regulation of transcription of Notch receptor target|viral process|negative regulation of myeloid cell differentiation|spleen development|ventricular septum morphogenesis|placenta blood vessel development|,nucleotide binding|protein binding|poly(A) RNA binding|,10,-0.3,0.0851,10,0.3,0.111,0,0,0.885,-4.6,4.2
ENSMUSG00000019979,APAF1,apoptotic peptidase activating factor 1,nucleus|cytosol|apoptosome|apoptosome|extracellular vesicular exosome|,neural tube closure|apoptotic DNA fragmentation|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|nervous system development|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|forebrain development|regulation of apoptotic process|positive regulation of apoptotic process|neuron apoptotic process|response to G1 DNA damage checkpoint signaling|intrinsic apoptotic signaling pathway|positive regulation of apoptotic signaling pathway|,nucleotide binding|protein binding|ATP binding|cysteine-type endopeptidase activator activity involved in apoptotic process|identical protein binding|ADP binding|,10,0,0,10,0,0,0,0,0.885,-3.3,3.2
ENSMUSG00000072720,MYO18B,myosin XVIIIB,nucleus|unconventional myosin complex|sarcomere|,metabolic process|,motor activity|actin binding|ATP binding|,10,0,0,10,0,0,0,0,0.885,-3.6,2
ENSMUSG00000047821,TRIM16,tripartite motif containing 16,cytoplasm|PML body|,"response to retinoic acid|histone H3 acetylation|histone H4 acetylation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|response to organophosphorus|positive regulation of retinoic acid receptor signaling pathway|positive regulation of interleukin-1 beta secretion|response to growth hormone|",DNA binding|protein binding|zinc ion binding|interleukin-1 binding|NACHT domain binding|,0,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000020163,UQCR11,"ubiquinol-cytochrome c reductase, complex III subunit XI",mitochondrial inner membrane|integral component of membrane|respiratory chain|,generation of precursor metabolites and energy|respiratory electron transport chain|cellular metabolic process|small molecule metabolic process|hydrogen ion transmembrane transport|,ubiquinol-cytochrome-c reductase activity|electron carrier activity|,10,0,0,10,0.4,0.159,0,0,0.885,-8.7,3
ENSMUSG00000032174,ICAM5,"intercellular adhesion molecule 5, telencephalin",plasma membrane|integral component of plasma membrane|,phagocytosis|single organismal cell-cell adhesion|,protein binding|,10,-1.2,0.00172,10,-0.8,0.0266,0,0,0.885,-3.4,1.5
ENSMUSG00000032369,PLSCR1,phospholipid scramblase 1,nucleus|nucleolus|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|membrane|extracellular matrix|membrane raft|extracellular vesicular exosome|,phosphatidylserine biosynthetic process|apoptotic process|acute-phase response|positive regulation of gene expression|phospholipid scrambling|platelet activation|regulation of mast cell activation|response to interferon-beta|negative regulation of viral genome replication|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|,RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|DNA binding|epidermal growth factor receptor binding|calcium ion binding|calcium ion binding|protein binding|SH3 domain binding|phospholipid scramblase activity|enzyme binding|CD4 receptor binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000071322,TCP10A,t-complex protein 10a,cellular_component|,biological_process|,molecular_function|,10,0,0,10,-0.3,0.0952,0,0,0.885,-2.6,3.1
ENSMUSG00000064109,HCST,hematopoietic cell signal transducer,plasma membrane|cell surface|integral component of membrane|,positive regulation of phosphatidylinositol 3-kinase signaling|regulation of immune response|,receptor binding|protein binding|phosphatidylinositol 3-kinase binding|,10,0,0,10,0,0,0,0,0.885,-5.8,3.7
ENSMUSG00000026609,USH2A,"Usher syndrome 2A (autosomal recessive, mild)",stereocilia ankle link complex|basement membrane|cytoplasm|integral component of membrane|apical plasma membrane|stereocilium bundle|stereocilium membrane|,visual perception|sensory perception of sound|hair cell differentiation|photoreceptor cell maintenance|maintenance of organ identity|response to stimulus|sensory perception of light stimulus|inner ear receptor cell differentiation|,protein binding|collagen binding|myosin binding|,10,-0.5,0.246,10,0,0,0,0,0.885,-3.5,2
ENSMUSG00000008461,FUT1,"fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)",Golgi apparatus|integral component of plasma membrane|membrane|Golgi cisterna membrane|,carbohydrate metabolic process|protein glycosylation|protein glycosylation|fucosylation|L-fucose catabolic process|,galactoside 2-alpha-L-fucosyltransferase activity|fucosyltransferase activity|,10,0,0,10,4.1,0.0614,0,0,0.885,-3.6,7.2
ENSMUSG00000091102,5830462I19RIK,RIKEN cDNA 5830462I19 gene,cellular_component|,biological_process|,molecular_function|,1,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000024201,KDM4B,lysine (K)-specific demethylase 4B,nucleus|focal adhesion|cell junction|,"transcription, DNA-templated|regulation of transcription, DNA-templated|chromatin modification|oxidation-reduction process|",zinc ion binding|dioxygenase activity|,10,0,0,10,0,0,0,0,0.885,-2.6,3.1
ENSMUSG00000049932,H2AFX,"H2A histone family, member X","chromosome, telomeric region|nucleosome|nuclear chromatin|condensed nuclear chromosome|male germ cell nucleus|XY body|nucleus|nucleoplasm|replication fork|site of double-strand break|",DNA damage checkpoint|double-strand break repair via homologous recombination|DNA repair|double-strand break repair|double-strand break repair|nucleosome assembly|cellular response to DNA damage stimulus|meiotic nuclear division|spermatogenesis|response to ionizing radiation|positive regulation of DNA repair|,DNA binding|damaged DNA binding|protein binding|enzyme binding|histone binding|protein heterodimerization activity|,10,0,0,10,0,0,0,0,0.885,-2,2.2
ENSMUSG00000061607,MDC1,mediator of DNA-damage checkpoint 1,nucleus|nucleoplasm|chromosome|focal adhesion|,double-strand break repair via homologous recombination|DNA repair|double-strand break repair|intra-S DNA damage checkpoint|,protein binding|protein C-terminus binding|FHA domain binding|,10,-0.2,0.0234,10,0,0,0,0,0.885,-5.7,3.1
ENSMUSG00000043279,TRIM56,tripartite motif containing 56,cytoplasm|cytosol|,regulation of type I interferon production|positive regulation of type I interferon production|interferon-beta production|response to type I interferon|innate immune response|defense response to virus|protein K63-linked ubiquitination|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|zinc ion binding|ligase activity|poly(A) RNA binding|,1,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000015354,PCOLCE2,procollagen C-endopeptidase enhancer 2,extracellular vesicular exosome|,positive regulation of peptidase activity|,collagen binding|heparin binding|peptidase activator activity|,10,0,0,10,0,0,0,0,0.885,-2,4.3
ENSMUSG00000031570,PPAPDC1B,phosphatidic acid phosphatase type 2 domain containing 1B,cytoplasm|plasma membrane|integral component of membrane|,phospholipid dephosphorylation|,phosphatidate phosphatase activity|,10,0,0,10,-1.7,0.469,0,0,0.885,-6.2,2.5
ENSMUSG00000074277,PHLDB3,"pleckstrin homology-like domain, family B, member 3",None,None,enzyme binding|,10,0,0,10,2.1,0.716,0,0,0.885,-6.7,7
ENSMUSG00000032030,CUL5,cullin 5,nucleus|cytosol|plasma membrane|Cul5-RING ubiquitin ligase complex|,G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process|response to osmotic stress|cell cycle arrest|cell proliferation|negative regulation of cell proliferation|viral process|protein ubiquitination|cytosolic calcium ion homeostasis|calcium ion transmembrane transport|intrinsic apoptotic signaling pathway|,receptor activity|calcium channel activity|protein binding|ubiquitin protein ligase binding|,10,-1.4,1.41,10,0.1,0.0136,0,0,0.885,-5,2
ENSMUSG00000037526,ATG14,autophagy related 14,nucleus|cytoplasm|autophagic vacuole|endoplasmic reticulum membrane|axoneme|pre-autophagosomal structure membrane|,autophagic vacuole assembly|positive regulation of autophagy|,protein binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2
ENSMUSG00000022615,TYMP,thymidine phosphorylase,cytosol|,mitochondrial genome maintenance|angiogenesis|pyrimidine nucleobase metabolic process|pyrimidine nucleotide metabolic process|DNA replication|chemotaxis|cell differentiation|pyrimidine nucleoside salvage|small molecule metabolic process|pyrimidine nucleoside catabolic process|nucleobase-containing small molecule metabolic process|,"phosphorylase activity|platelet-derived growth factor receptor binding|growth factor activity|thymidine phosphorylase activity|pyrimidine-nucleoside phosphorylase activity|transferase activity, transferring pentosyl groups|",10,0.3,0.0712,10,0,0,0,0,0.885,-3.4,6.3
ENSMUSG00000034730,BAI1,brain-specific angiogenesis inhibitor 1,plasma membrane|integral component of plasma membrane|cell-cell junction|integral component of membrane|,cell adhesion|signal transduction|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|axonogenesis|peripheral nervous system development|negative regulation of cell proliferation|negative regulation of angiogenesis|,G-protein coupled receptor activity|,10,0,0,10,-0.3,0.0312,0,0,0.885,-4.7,3
ENSMUSG00000072214,5-Sep,septin 5,plasma membrane|synaptic vesicle|septin complex|terminal bouton|,cytokinesis|GTP catabolic process|synaptic vesicle targeting|regulation of exocytosis|,GTPase activity|structural molecule activity|protein binding|GTP binding|,10,0.3,0.124,10,0,0,0,0,0.885,-3.1,2.6
ENSMUSG00000005087,CD44,CD44 molecule (Indian blood group),cytoplasm|Golgi apparatus|plasma membrane|plasma membrane|integral component of plasma membrane|external side of plasma membrane|cell surface|basolateral plasma membrane|extracellular vesicular exosome|,"branching involved in ureteric bud morphogenesis|wound healing involved in inflammatory response|carbohydrate metabolic process|cell-matrix adhesion|blood coagulation|positive regulation of gene expression|Wnt signaling pathway|single organismal cell-cell adhesion|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|glycosaminoglycan metabolic process|hyaluronan metabolic process|hyaluronan catabolic process|hyaluronan catabolic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of heterotypic cell-cell adhesion|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of DNA damage response, signal transduction by p53 class mediator|small molecule metabolic process|cellular response to fibroblast growth factor stimulus|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|cartilage development|interferon-gamma-mediated signaling pathway|branching involved in prostate gland morphogenesis|positive regulation of ERK1 and ERK2 cascade|monocyte aggregation|positive regulation of monocyte aggregation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|",hyalurononglucosaminidase activity|transmembrane signaling receptor activity|protein binding|collagen binding|hyaluronic acid binding|hyaluronic acid binding|,10,0,0,10,0,0,0,0,0.885,-9.1,3
ENSMUSG00000027011,UBE2E3,ubiquitin-conjugating enzyme E2E 3,nucleus|cytoplasm|,regulation of growth|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|,ubiquitin-protein transferase activity|ATP binding|acid-amino acid ligase activity|,10,0.3,0.0573,10,0,0,0,0,0.885,-3.5,6.3
ENSMUSG00000029713,GNB2,"guanine nucleotide binding protein (G protein), beta polypeptide 2",extracellular space|lysosomal membrane|plasma membrane|membrane|protein complex|cell body|perinuclear region of cytoplasm|extracellular vesicular exosome|,energy reserve metabolic process|GTP catabolic process|G-protein coupled receptor signaling pathway|synaptic transmission|small molecule metabolic process|cellular response to glucagon stimulus|,GTPase activity|signal transducer activity|calcium channel regulator activity|protein binding|protein complex binding|GTPase binding|,10,-0.4,0.235,10,0,0,0,0,0.885,-10,4.6
ENSMUSG00000026436,ELK4,"ELK4, ETS-domain protein (SRF accessory protein 1)",nucleus|cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell differentiation|histone H3 deacetylation|,sequence-specific DNA binding RNA polymerase II transcription factor activity|core promoter binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|protein binding|sequence-specific DNA binding|,10,0.3,0.0278,10,0,0,0,0,0.885,-3,2.6
ENSMUSG00000091471,GM20538,N/A,None,None,None,1,0.3,0.0347,1,-0.7,0.0881,0,0,0.885,-2,1.8
ENSMUSG00000036928,STAG3,stromal antigen 3,"chromosome, centromeric region|synaptonemal complex|lateral element|transverse filament|male germ cell nucleus|extracellular space|nucleus|nucleolus|meiotic cohesin complex|",chromosome segregation|synaptonemal complex assembly|,None,10,0,0,10,-0.2,0.0409,0,0,0.885,-3.7,4.3
ENSMUSG00000039943,PLCB4,"phospholipase C, beta 4",nucleus|smooth endoplasmic reticulum|cytosol|postsynaptic density|dendrite|,lipid catabolic process|intracellular signal transduction|inositol phosphate metabolic process|small molecule metabolic process|,phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|calcium ion binding|,10,-0.3,0.0427,10,0,0,0,0,0.885,-10.1,2
ENSMUSG00000032191,BCL2L10,BCL2-like 10 (apoptosis facilitator),mitochondrion|mitochondrial outer membrane|cytosol|membrane|integral component of membrane|nuclear membrane|,activation of cysteine-type endopeptidase activity involved in apoptotic process|spermatogenesis|female gamete generation|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|,protein binding|protein homodimerization activity|protein heterodimerization activity|,10,0,0,10,-0.3,0.0646,0,0,0.885,-2.5,2.5
ENSMUSG00000028464,TPM2,tropomyosin 2 (beta),cytosol|muscle thin filament tropomyosin|,muscle contraction|muscle filament sliding|regulation of ATPase activity|,actin binding|structural constituent of muscle|,10,0,0,10,0.2,0.0433,0,0,0.885,-2.7,2
ENSMUSG00000006498,PTBP1,polypyrimidine tract binding protein 1,nucleoplasm|nucleolus|membrane|extracellular vesicular exosome|,"alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|mRNA processing|RNA splicing|gene expression|negative regulation of RNA splicing|negative regulation of mRNA splicing, via spliceosome|negative regulation of muscle cell differentiation|",nucleotide binding|RNA binding|protein binding|poly-pyrimidine tract binding|pre-mRNA binding|poly(A) RNA binding|,10,-1.3,0.194,10,0.1,0.0117,0,0,0.885,-3.4,2.3
ENSMUSG00000003282,PLAG1,pleiomorphic adenoma gene 1,nucleus|,transcription from RNA polymerase II promoter|negative regulation of gene expression|gland morphogenesis|multicellular organism growth|organ growth|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glial cell proliferation|prostate gland growth|,RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|metal ion binding|,10,-0.7,0.405,10,0,0,0,0,0.885,-5.8,2
ENSMUSG00000040093,BMF,Bcl2 modifying factor,acrosomal vesicle|mitochondrial outer membrane|cytosol|plasma membrane|myosin complex|,apoptotic process|positive regulation of protein homooligomerization|anoikis|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,protein binding|,10,0,0,10,0,0,0,0,0.885,-4.2,2
ENSMUSG00000031997,TRPC6,"transient receptor potential cation channel, subfamily C, member 6",plasma membrane|plasma membrane|integral component of membrane|slit diaphragm|,cation transport|positive regulation of cytosolic calcium ion concentration|axon guidance|aging|blood coagulation|platelet activation|positive regulation of ion transmembrane transporter activity|ion transmembrane transport|positive regulation of calcium ion transport|transmembrane transport|cellular response to hydrogen peroxide|calcium ion transmembrane transport|cellular response to hypoxia|,"protein binding|store-operated calcium channel activity|inositol 1,4,5 trisphosphate binding|",10,0.5,0.0683,10,0,0,0,0,0.885,-4,4.6
ENSMUSG00000028393,ALAD,aminolevulinate dehydratase,nucleus|cytosol|extracellular vesicular exosome|,porphyrin-containing compound metabolic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|heme biosynthetic process|small molecule metabolic process|protein homooligomerization|cellular response to interleukin-4|,catalytic activity|porphobilinogen synthase activity|porphobilinogen synthase activity|zinc ion binding|lead ion binding|identical protein binding|,10,0.3,0.0556,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000071723,GSPT2,G1 to S phase transition 2,cytosol|,"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|GTP catabolic process|translation|translational termination|cell cycle|gene expression|RNA metabolic process|mRNA metabolic process|cellular protein metabolic process|",GTPase activity|protein binding|GTP binding|poly(A) RNA binding|,10,-0.2,0.0365,10,0.4,0.209,0,0,0.885,-4,3.8
ENSMUSG00000008855,HDAC5,histone deacetylase 5,histone deacetylase complex|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|nuclear body|,"negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|chromatin organization|chromatin remodeling|chromatin silencing|transcription, DNA-templated|inflammatory response|Notch signaling pathway|heart development|regulation of myotube differentiation|negative regulation of myotube differentiation|chromatin modification|histone deacetylation|B cell differentiation|cellular response to insulin stimulus|multicellular organismal response to stress|B cell activation|response to cocaine|response to drug|regulation of protein binding|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of skeletal muscle fiber development|positive regulation of sequence-specific DNA binding transcription factor activity|histone H3 deacetylation|histone H4 deacetylation|negative regulation of cell migration involved in sprouting angiogenesis|",transcription corepressor activity|histone deacetylase activity|protein kinase C binding|protein binding|transcription factor binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|transcription regulatory region DNA binding|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|repressing transcription factor binding|NAD-dependent histone deacetylase activity (H3-K18 specific)|,10,0,0,10,0,0,0,0,0.885,-9.1,2
ENSMUSG00000074781,UBE2N,ubiquitin-conjugating enzyme E2N,ubiquitin ligase complex|nucleus|cytoplasm|cytoplasm|cytosol|UBC13-MMS2 complex|UBC13-UEV1A complex|protein complex|extracellular vesicular exosome|,"double-strand break repair via homologous recombination|DNA double-strand break processing|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|regulation of DNA repair|postreplication repair|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein ubiquitination|histone ubiquitination|cytokine-mediated signaling pathway|positive regulation of histone modification|regulation of histone ubiquitination|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 9 signaling pathway|toll-like receptor 10 signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|Fc-epsilon receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of DNA repair|T cell receptor signaling pathway|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein transferase activity|nucleotide-binding oligomerization domain containing signaling pathway|protein K63-linked ubiquitination|",ubiquitin-protein transferase activity|protein binding|ATP binding|acid-amino acid ligase activity|ubiquitin binding|poly(A) RNA binding|,7,-1.1,0.0706,8,0,0,0,0,0.885,-2.8,1.6
ENSMUSG00000038780,SMURF1,SMAD specific E3 ubiquitin protein ligase 1,nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|neuronal cell body|extracellular vesicular exosome|,protein polyubiquitination|protein export from nucleus|transforming growth factor beta receptor signaling pathway|ectoderm development|protein ubiquitination|cell differentiation|negative regulation of ossification|BMP signaling pathway|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|receptor catabolic process|protein localization to cell surface|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|,ubiquitin-protein transferase activity|ubiquitin-protein transferase activity|protein binding|ligase activity|activin binding|I-SMAD binding|R-SMAD binding|,10,-0.5,0.0578,10,0,0,0,0,0.885,-2.7,2.2
ENSMUSG00000031432,PRPS1,phosphoribosyl pyrophosphate synthetase 1,ribose phosphate diphosphokinase complex|cytosol|,carbohydrate metabolic process|5-phosphoribose 1-diphosphate biosynthetic process|5-phosphoribose 1-diphosphate biosynthetic process|purine nucleobase metabolic process|purine nucleotide biosynthetic process|AMP biosynthetic process|pyrimidine nucleotide biosynthetic process|nervous system development|cell death|phosphorylation|organ regeneration|urate biosynthetic process|small molecule metabolic process|hypoxanthine biosynthetic process|,magnesium ion binding|ribose phosphate diphosphokinase activity|ribose phosphate diphosphokinase activity|ribose phosphate diphosphokinase activity|ATP binding|AMP binding|kinase activity|GDP binding|carbohydrate binding|protein homodimerization activity|ADP binding|,10,0.1,0.0272,10,0,0,0,0,0.885,-3.4,3.9
ENSMUSG00000022969,IL10RB,"interleukin 10 receptor, beta",plasma membrane|integral component of membrane|interleukin-28 receptor complex|extracellular vesicular exosome|,inflammatory response|immune response|signal transduction|cytokine-mediated signaling pathway|,receptor activity|interleukin-10 receptor activity|protein binding|,7,-0.1,0.00172,7,0,0,0,0,0.885,-5,4.2
ENSMUSG00000003974,GRM3,"glutamate receptor, metabotropic 3",plasma membrane|integral component of plasma membrane|postsynaptic density|axon|presynaptic membrane|dendritic spine|postsynaptic membrane|astrocyte projection|,"negative regulation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|synaptic transmission|regulation of synaptic transmission, glutamatergic|",group II metabotropic glutamate receptor activity|G-protein coupled receptor activity|calcium channel regulator activity|glutamate receptor activity|,10,-3,0.494,10,0,0,0,0,0.885,-8.1,4
ENSMUSG00000001435,COL18A1,"collagen, type XVIII, alpha 1",extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix|extracellular matrix|extracellular vesicular exosome|,angiogenesis|endothelial cell morphogenesis|cell adhesion|visual perception|positive regulation of cell proliferation|negative regulation of cell proliferation|organ morphogenesis|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell migration|collagen catabolic process|response to drug|response to hydrostatic pressure|positive regulation of endothelial cell apoptotic process|,structural molecule activity|protein binding|identical protein binding|metal ion binding|,9,1,0.143,9,0,0,0,0,0.885,-3.1,4.1
ENSMUSG00000038508,GDF15,growth differentiation factor 15,extracellular region|extracellular space|extracellular vesicular exosome|,signal transduction|transforming growth factor beta receptor signaling pathway|cell-cell signaling|,cytokine activity|growth factor activity|,10,0,0,10,0,0,0,0,0.885,-7.6,2
ENSMUSG00000049709,NLRP10,"NLR family, pyrin domain containing 10",cytoplasm|extrinsic component of plasma membrane|,positive regulation of T-helper 1 type immune response|helper T cell enhancement of adaptive immune response|dendritic cell migration|innate immune response|defense response to Gram-negative bacterium|defense response to fungus|positive regulation of T-helper 17 type immune response|positive regulation of interleukin-8 secretion|positive regulation of interleukin-6 secretion|,ATP binding|,10,-0.6,0.162,10,0.5,0.199,0,0,0.885,-4.5,5.9
ENSMUSG00000045521,TSSK2,testis-specific serine kinase 2,acrosomal vesicle|nucleus|cytoplasm|centriole|,protein phosphorylation|multicellular organismal development|spermatid development|protein autophosphorylation|,magnesium ion binding|magnesium ion binding|protein serine/threonine kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|,9,0.7,0.178,10,0,0,0,0,0.885,-2,2.8
ENSMUSG00000027750,POSTN,"periostin, osteoblast specific factor",proteinaceous extracellular matrix|trans-Golgi network|extracellular matrix|,skeletal system development|cell adhesion|regulation of Notch signaling pathway|tissue development|extracellular matrix organization|,protein binding|heparin binding|,10,4.1,0.488,10,0.3,0.0577,0,0,0.885,-2.8,7.8
ENSMUSG00000071533,PCNP,PEST proteolytic signal containing nuclear protein,nucleus|,cell cycle|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|,protein binding|,10,0,0,10,1,0.499,0,0,0.885,-3.2,3.7
ENSMUSG00000053469,TG,thyroglobulin,extracellular region|extracellular space|,thyroid hormone generation|signal transduction|iodide transport|thyroid gland development|regulation of myelination|hormone biosynthetic process|,hormone activity|,10,0,0,10,0,0,0,0,0.885,-7.1,3.4
ENSMUSG00000022382,WNT7B,"wingless-type MMTV integration site family, member 7B",extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|,in utero embryonic development|metanephros morphogenesis|activation of JUN kinase activity|positive regulation of cell proliferation|positive regulation of gene expression|Wnt signaling pathway|Wnt signaling pathway|establishment or maintenance of polarity of embryonic epithelium|forebrain regionalization|central nervous system vasculogenesis|neuron differentiation|lung development|oxygen homeostasis|regulation of cell projection size|odontogenesis of dentin-containing tooth|homeostatic process|cellular metabolic process|cell fate commitment|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|positive regulation of JNK cascade|fibroblast proliferation|embryonic organ development|neuron projection morphogenesis|synapse organization|smooth muscle cell differentiation|response to glucocorticoid|anatomical structure regression|canonical Wnt signaling pathway|lung morphogenesis|lung epithelium development|lobar bronchus development|lung-associated mesenchyme development|trachea cartilage morphogenesis|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|chorio-allantoic fusion|mammary gland epithelium development|lens fiber cell development|cellular response to retinoic acid|renal inner medulla development|renal outer medulla development|outer medullary collecting duct development|inner medullary collecting duct development|stem cell proliferation|metanephric collecting duct development|metanephric epithelium development|metanephric loop of Henle development|apoptotic process involved in patterning of blood vessels|,frizzled binding|,10,0.1,0.00409,10,0,0,0,0,0.885,-5.5,3
ENSMUSG00000022292,RRM2B,ribonucleotide reductase M2 B (TP53 inducible),nucleus|nucleoplasm|cytoplasm|extracellular vesicular exosome|,kidney development|renal system process|mitochondrial DNA replication|DNA repair|response to oxidative stress|deoxyribonucleoside diphosphate metabolic process|deoxyribonucleoside triphosphate metabolic process|deoxyribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|small molecule metabolic process|nucleobase-containing small molecule metabolic process|oxidation-reduction process|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|,"ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|metal ion binding|",10,-3.1,0.713,10,0,0,0,0,0.885,-6.5,2.4
ENSMUSG00000037321,TAP1,"transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)",mitochondrion|endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|TAP complex|,"antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP catabolic process|defense response|peptide transport|intracellular transport of viral protein in host cell|antigen processing and presentation of endogenous peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I|cytosol to ER transport|transmembrane transport|","protein binding|ATP binding|peptide transporter activity|peptide transporter activity|MHC class Ib protein binding|MHC class I protein binding|peptide antigen binding|ATPase activity, coupled to transmembrane movement of substances|protein homodimerization activity|ADP binding|TAP1 binding|TAP2 binding|",10,0,0,10,0,0,0,0,0.885,-7.5,2
ENSMUSG00000007655,CAV1,"caveolin 1, caveolae protein, 22kDa",Golgi membrane|Golgi membrane|acrosomal membrane|intracellular|endosome|endoplasmic reticulum|lipid particle|plasma membrane|plasma membrane|integral component of plasma membrane|caveola|caveola|cilium|cell cortex|basolateral plasma membrane|apical plasma membrane|endocytic vesicle membrane|cytoplasmic vesicle|protein complex|membrane raft|perinuclear region of cytoplasm|perinuclear region of cytoplasm|,negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|inactivation of MAPK activity|angiogenesis|vasculogenesis|response to hypoxia|negative regulation of endothelial cell proliferation|negative regulation of cytokine-mediated signaling pathway|response to ischemia|regulation of the force of heart contraction by chemical signal|triglyceride metabolic process|calcium ion transport|cellular calcium ion homeostasis|regulation of smooth muscle contraction|skeletal muscle tissue development|lactation|blood coagulation|protein localization|cellular response to starvation|positive regulation of calcium ion transport into cytosol|positive regulation of peptidase activity|viral process|vesicle organization|regulation of fatty acid metabolic process|lipid storage|regulation of blood coagulation|cholesterol transport|negative regulation of BMP signaling pathway|negative regulation of epithelial cell differentiation|mammary gland development|T cell costimulation|negative regulation of protein ubiquitination|negative regulation of protein binding|maintenance of protein location in cell|response to progesterone|negative regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation|nitric oxide homeostasis|vasoconstriction|negative regulation of tyrosine phosphorylation of Stat5 protein|cholesterol homeostasis|cholesterol homeostasis|negative regulation of MAPK cascade|response to estrogen|small molecule metabolic process|negative regulation of nitric oxide biosynthetic process|positive regulation of vasoconstriction|nitric oxide metabolic process|negative regulation of JAK-STAT cascade|negative regulation of pinocytosis|positive regulation of metalloenzyme activity|leukocyte migration|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|protein homooligomerization|cytosolic calcium ion homeostasis|response to calcium ion|membrane depolarization|regulation of peptidase activity|calcium ion homeostasis|mammary gland involution|caveola assembly|cellular response to hyperoxia|caveolin-mediated endocytosis|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|receptor internalization involved in canonical Wnt signaling pathway|negative regulation of anoikis|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|,receptor binding|patched binding|structural molecule activity|protein binding|cholesterol binding|peptidase activator activity|enzyme binding|protein complex scaffold|nitric-oxide synthase binding|,10,0,0,10,-0.4,0.0644,0,0,0.885,-2.8,2
ENSMUSG00000020932,GFAP,glial fibrillary acidic protein,cytoplasm|cytosol|intermediate filament|membrane|cell body|astrocyte projection|,response to wounding|positive regulation of Schwann cell proliferation|negative regulation of neuron projection development|astrocyte development|extracellular matrix organization|neuron projection regeneration|intermediate filament organization|regulation of neurotransmitter uptake|Bergmann glial cell differentiation|long-term synaptic potentiation|,integrin binding|structural constituent of cytoskeleton|kinase binding|,10,0,0,10,0,0,0,0,0.885,-3.5,2.3
ENSMUSG00000007613,TGFBR1,"transforming growth factor, beta receptor 1",plasma membrane|plasma membrane|tight junction|receptor complex|transforming growth factor beta receptor homodimeric complex|,"activation of MAPKK activity|skeletal system development|angiogenesis|in utero embryonic development|kidney development|blastocyst development|epithelial to mesenchymal transition|negative regulation of endothelial cell proliferation|lens development in camera-type eye|regulation of transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|cell cycle arrest|signal transduction|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|heart development|positive regulation of cell proliferation|germ cell migration|post-embryonic development|anterior/posterior pattern specification|positive regulation of pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|signal transduction by phosphorylation|collagen fibril organization|positive regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of protein ubiquitination|negative regulation of chondrocyte differentiation|wound healing|extracellular structure organization|negative regulation of apoptotic process|regulation of protein binding|endothelial cell migration|positive regulation of transcription, DNA-templated|thymus development|neuron fate commitment|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|mesenchymal cell differentiation|artery morphogenesis|cell motility|positive regulation of cellular component movement|positive regulation of filopodium assembly|positive regulation of protein kinase B signaling|parathyroid gland development|palate development|pharyngeal system development|pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|response to cholesterol|cellular response to transforming growth factor beta stimulus|positive regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|","protein kinase activity|protein serine/threonine kinase activity|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding|protein binding|ATP binding|growth factor binding|SMAD binding|SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta binding|transforming growth factor beta binding|I-SMAD binding|",10,0,0,10,0.3,0.14,0,0,0.885,-7.2,9.2
ENSMUSG00000028938,GALNTL5,polypeptide N-acetylgalactosaminyltransferase-like 5,integral component of membrane|late endosome membrane|,spermatid development|,metal ion binding|,10,0,0,10,0,0,0,0,0.885,-3,3.5
ENSMUSG00000046886,ZFP474,zinc finger protein 474,cellular_component|,biological_process|,molecular_function|metal ion binding|,1,0,0,0,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000016477,E2F3,E2F transcription factor 3,nucleus|nucleoplasm|transcription factor complex|cytoplasm|Golgi apparatus|intracellular membrane-bounded organelle|,"mitotic G2 phase|mitotic cell cycle|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of cell proliferation|positive regulation of transcription, DNA-templated|",core promoter binding|sequence-specific DNA binding transcription factor activity|protein binding|,10,0,0,10,-0.2,0.0254,0,0,0.885,-3.4,5.6
ENSMUSG00000070520,NDNL2,necdin-like 2,"chromosome, telomeric region|nucleus|cytoplasm|Smc5-Smc6 complex|","DNA repair|DNA recombination|regulation of transcription, DNA-templated|positive regulation of protein ubiquitination|regulation of growth|",protein binding|,0,0,0,1,0,0,0,0,0.885,-1.9,1.9
ENSMUSG00000024339,TAP2,"transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)",endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|TAP complex|,"antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|ATP catabolic process|intracellular transport of viral protein in host cell|antigen processing and presentation of endogenous peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I|cytosol to ER transport|peptide antigen transport|peptide antigen transport|transmembrane transport|",transporter activity|protein binding|ATP binding|peptide transporter activity|peptide antigen-transporting ATPase activity|MHC class Ib protein binding|TAP1 binding|tapasin binding|,10,-0.2,0.0481,10,0,0,0,0,0.885,-4.8,4.5
ENSMUSG00000032306,MPI,mannose phosphate isomerase,cytosol|extracellular vesicular exosome|,dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|GDP-mannose biosynthetic process|protein N-linked glycosylation via asparagine|post-translational protein modification|cellular protein metabolic process|,mannose-6-phosphate isomerase activity|zinc ion binding|,10,0.1,0.00462,10,0,0,0,0,0.885,-3.4,2.9
ENSMUSG00000032743,D430042O09RIK,RIKEN cDNA D430042O09 gene,extracellular space|nucleus|plasma membrane|,biological_process|,molecular_function|,10,0,0,10,0,0,0,0,0.885,-6.4,3
ENSMUSG00000035045,ZC3H12B,zinc finger CCCH-type containing 12B,None,nucleic acid phosphodiester bond hydrolysis|,endonuclease activity|metal ion binding|,10,0.4,0.235,10,0,0,0,0,0.885,-2.6,3.7
ENSMUSG00000043858,NUP62,nucleoporin 62kDa,spindle pole|nuclear envelope|nuclear envelope|nuclear pore|nuclear pore|cytoplasm|ribonucleoprotein complex|nucleocytoplasmic shuttling complex|nuclear membrane|intracellular membrane-bounded organelle|pore complex|,"mitotic cell cycle|carbohydrate metabolic process|transcription, DNA-templated|transcription, DNA-templated|nucleocytoplasmic transport|mitotic nuclear envelope disassembly|cell surface receptor signaling pathway|cell surface receptor signaling pathway|cell surface receptor signaling pathway|cell aging|cell death|cell death|negative regulation of cell proliferation|negative regulation of cell proliferation|hexose transport|hormone-mediated signaling pathway|regulation of signal transduction|regulation of glucose transport|protein transport|glucose transport|viral process|cytokine-mediated signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of programmed cell death|negative regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|small molecule metabolic process|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|mRNA transport|transmembrane transport|",chromatin binding|nucleocytoplasmic transporter activity|protein binding|structural constituent of nuclear pore|receptor signaling complex scaffold activity|receptor signaling complex scaffold activity|SH2 domain binding|SH2 domain binding|ubiquitin binding|ubiquitin binding|thyroid hormone receptor binding|thyroid hormone receptor binding|PTB domain binding|,10,0,0,10,0,0,0,0,0.885,-3.2,3.2
ENSMUSG00000041219,ARHGAP11A,Rho GTPase activating protein 11A,cytosol|,small GTPase mediated signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|,GTPase activator activity|,10,-1.2,0.23,10,0.2,0.022,0,0,0.885,-3.4,2.2
ENSMUSG00000076432,YWHAQ,"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta",cytoplasm|cytosol|membrane|cytoplasmic vesicle membrane|extracellular vesicular exosome|,"protein targeting|apoptotic process|small GTPase mediated signal transduction|substantia nigra development|negative regulation of transcription, DNA-templated|membrane organization|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|",protein binding|protein domain specific binding|protein N-terminus binding|,10,0,0,10,1.3,0.635,0,0,0.885,-3,4.1
ENSMUSG00000017843,PPP2R5C,"protein phosphatase 2, regulatory subunit B', gamma","protein phosphatase type 2A complex|protein phosphatase type 2A complex|chromosome, centromeric region|nucleus|","DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of catalytic activity|regulation of catalytic activity|regulation of catalytic activity|",protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity|,1,0,0,0,0,0,0,0,0.885,-2,1.8
ENSMUSG00000032356,RASGRF1,Ras protein-specific guanine nucleotide-releasing factor 1,cytosol|plasma membrane|plasma membrane|growth cone|neuron projection|,signal transduction|small GTPase mediated signal transduction|synaptic transmission|long-term memory|neuron projection development|positive regulation of Ras GTPase activity|activation of Rac GTPase activity|regulation of Rac protein signal transduction|regulation of Ras protein signal transduction|positive regulation of Ras protein signal transduction|regulation of synaptic plasticity|,guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|,10,0,0,10,0,0,0,0,0.885,-5.1,2.9
ENSMUSG00000037679,INF2,"inverted formin, FH2 and WH2 domain containing",nucleus|cytoplasm|endoplasmic reticulum|perinuclear region of cytoplasm|,cell death|actin cytoskeleton organization|regulation of cellular component size|regulation of mitochondrial fission|,actin binding|Rho GTPase binding|,9,-0.3,0.144,9,0,0,0,0,0.885,-3.2,2.6
ENSMUSG00000042303,SGSM3,small G protein signaling modulator 3,cytoplasm|gap junction|,cell cycle arrest|regulation of Rab protein signal transduction|Rap protein signal transduction|positive regulation of Rab GTPase activity|positive regulation of protein catabolic process|,Rab GTPase activator activity|protein binding|Rab GTPase binding|,10,-0.3,0.0872,10,0,0,0,0,0.885,-2.4,1.8
ENSMUSG00000024012,MTCH1,mitochondrial carrier 1,intracellular|mitochondrion|mitochondrial inner membrane|integral component of membrane|,transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of signal transduction|positive regulation of apoptotic process|neuronal ion channel clustering|,protein binding|,10,0,0,10,0.4,0.0348,0,0,0.885,-3.6,6.1
ENSMUSG00000029752,ASNS,asparagine synthetase (glutamine-hydrolyzing),cytosol|,liver development|asparagine biosynthetic process|asparagine biosynthetic process|glutamine metabolic process|activation of signaling protein activity involved in unfolded protein response|cellular amino acid biosynthetic process|response to light stimulus|response to mechanical stimulus|response to toxic substance|endoplasmic reticulum unfolded protein response|response to methotrexate|response to follicle-stimulating hormone|cellular response to hormone stimulus|cellular nitrogen compound metabolic process|cellular response to glucose starvation|negative regulation of apoptotic process|response to amino acid|cellular protein metabolic process|small molecule metabolic process|positive regulation of mitotic cell cycle|L-asparagine biosynthetic process|,asparagine synthase (glutamine-hydrolyzing) activity|asparagine synthase (glutamine-hydrolyzing) activity|ATP binding|protein homodimerization activity|cofactor binding|,9,0,0,10,-0.7,0.216,0,0,0.885,-4.5,2.7
ENSMUSG00000028995,FAM126A,"family with sequence similarity 126, member A",cytoplasm|plasma membrane|,signal transduction|biological_process|,signal transducer activity|,0,0,0,1,0,0,0,0,0.885,-2,1.8
ENSMUSG00000038346,ZFP384,zinc finger protein 384,nucleus|focal adhesion|,nucleocytoplasmic transport|positive regulation of transcription from RNA polymerase II promoter|positive regulation of protein secretion|,SH3 domain binding|sequence-specific DNA binding|,10,0,0,10,0,0,0,0,0.885,-7.5,2
ENSMUSG00000022598,PSCA,prostate stem cell antigen,plasma membrane|anchored component of membrane|extracellular vesicular exosome|,None,None,10,0,0,10,0,0,0,0,0.885,-7.5,3
ENSMUSG00000048978,NRSN1,neurensin 1,integral component of membrane|cytoplasmic membrane-bounded vesicle|transport vesicle|growth cone|neuron projection|neuronal cell body|,nervous system development|,None,10,0,0,10,-0.6,0.0188,0,0,0.885,-5.2,2.8
ENSMUSG00000027611,PROCR,"protein C receptor, endothelial",centrosome|integral component of plasma membrane|extracellular vesicular exosome|,immune response|blood coagulation|antigen processing and presentation|negative regulation of coagulation|,receptor activity|protein binding|,10,-0.7,0.225,10,0.3,0.0574,0,0,0.885,-2.7,2.2
ENSMUSG00000020325,FSTL3,follistatin-like 3 (secreted glycoprotein),extracellular region|extracellular space|nucleus|Golgi apparatus|secretory granule|neuron projection terminus|,"ossification|kidney development|hematopoietic progenitor cell differentiation|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatogenesis|male gonad development|positive regulation of cell-cell adhesion|lung development|adrenal gland development|negative regulation of BMP signaling pathway|negative regulation of activin receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|cellular response to metal ion|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|",fibronectin binding|protein binding|activin binding|,10,0,0,10,0,0,0,0,0.885,-2,2.1
ENSMUSG00000029119,MAN2B2,"mannosidase, alpha, class 2B, member 2",lysosome|extracellular vesicular exosome|,mannose metabolic process|,alpha-mannosidase activity|zinc ion binding|carbohydrate binding|,10,-1,0.744,10,0.2,0.0206,0,0,0.885,-6,3.3
ENSMUSG00000025384,2310003H01RIK,RIKEN cDNA 2310003H01 gene,nucleus|cytoplasm|Fanconi anaemia nuclear complex|intermediate filament cytoskeleton|,DNA repair|cellular response to DNA damage stimulus|biological_process|,molecular_function|DNA binding|,10,0,0,10,0,0,0,0,0.885,-1.9,1.5
ENSMUSG00000059824,DBP,D site of albumin promoter (albumin D-box) binding protein,nucleus|,"liver development|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|",RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|,10,-1.5,1.29,10,0,0,0,0,0.885,-6.5,2.8
ENSMUSG00000073016,UPRT,uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae),nucleus|cytoplasm|,UMP biosynthetic process|female pregnancy|lactation|response to insulin|,None,10,0,0,10,0.3,0.158,0,0,0.885,-2,2.1
ENSMUSG00000066515,KLK1B3,kallikrein 1-related peptidase b3,nucleus|,proteolysis|intracellular signal transduction|,catalytic activity|serine-type endopeptidase activity|receptor signaling protein activity|growth factor activity|peptidase activity|serine-type peptidase activity|hydrolase activity|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-4.3,2.8
ENSMUSG00000046532,AR,androgen receptor,nuclear chromatin|nucleus|nucleoplasm|cytoplasm|protein complex|,"transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transport|signal transduction|cell-cell signaling|sex differentiation|cell death|cell proliferation|positive regulation of cell proliferation|gene expression|cell growth|androgen receptor signaling pathway|intracellular receptor signaling pathway|prostate gland development|positive regulation of phosphorylation|steroid hormone mediated signaling pathway|negative regulation of integrin biosynthetic process|positive regulation of integrin biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of establishment of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding|DNA binding|chromatin binding|sequence-specific DNA binding transcription factor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|androgen receptor activity|androgen receptor activity|androgen receptor activity|androgen receptor activity|receptor binding|androgen binding|protein binding|beta-catenin binding|beta-catenin binding|beta-catenin binding|transcription factor binding|zinc ion binding|enzyme binding|transcription regulatory region DNA binding|protein dimerization activity|,10,0,0,10,0,0,0,0,0.885,-2,2.9
ENSMUSG00000051413,PLAGL2,pleiomorphic adenoma gene-like 2,nucleus|,"transcription, DNA-templated|lipid metabolic process|post-embryonic development|chylomicron assembly|positive regulation of transcription from RNA polymerase II promoter|positive regulation of intrinsic apoptotic signaling pathway|",RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding|metal ion binding|,10,0,0,10,0,0,0,0,0.885,-2.9,2.7
ENSMUSG00000027823,GMPS,guanine monphosphate synthase,cytoplasm|cytosol|,purine nucleobase metabolic process|GMP biosynthetic process|glutamine metabolic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|small molecule metabolic process|nucleobase-containing small molecule metabolic process|,GMP synthase activity|GMP synthase (glutamine-hydrolyzing) activity|ATP binding|pyrophosphatase activity|,10,1,0.0869,9,0,0,0,0,0.885,-6.8,4.5
ENSMUSG00000050323,NDUFAF6,"NADH dehydrogenase (ubiquinone) complex I, assembly factor 6",nucleus|nucleus|cytoplasm|mitochondrial inner membrane|,biosynthetic process|mitochondrial respiratory chain complex I assembly|,transferase activity|,1,0,0,0,0,0,0,0,0.885,-2,1.8