Compound,SMILE,ALK2 IC50 (nM),ALK5 IC50 (nM)
M4K2286,CN(CC1)CCN1C(C=C2)=CC3=C2C4=C(O3)C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4,609,-
M4K2277,CN(CC1)CCN1C(C=C2)=CC3=C2C4=C(CO3)C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4,13,1541
M4K2207,COC1=CC(C2=CN=CC3=C2COCC4=CC(N5CCNCC5)=CC=C34)=CC(OC)=C1OC,2,104
M4K2303,CN(CC1)CCN1C(C=C2COC3)=CC=C2C4=C3C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4,3,187
M4K2308,COC1=CC(C2=CN=CC3=C2CCOC4=CC(N5CCNCC5)=CC=C34)=CC(OC)=C1OC,2,224
M4K2281,CN1CCN(C(C=C2OCC3)=CC=C2C4=C3C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4)CC1,2,350
M4K2304,CN(C1)CC2=CC(N3CCNCC3)=CC=C2C4=C1C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4,3,2500
M4K2306,CN(C1)CC2=CC(N3CCN(C)CC3)=CC=C2C4=C1C(C5=CC(OC)=C(OC)C(OC)=C5)=CN=C4,7,3915