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{"sheet":"Table1","index":0,"n_rows":200,"n_cols":12,"rows_kept":200,"cut":false,"hidden":false,"merged":[[2,5,2,9]]}
["Summary of ImmuneSet genes implicated in BP phenotypes in ConLiGen"]
[]
["Gene","Chr","Start","End","# Phenotypes","Associated phenotypes"]
["ALPL",1,21835858,21904905,1,"AAO",{"$nulls":5},"Prioritized for Li Response"]
["RAP1GAP",1,21922708,21995801,1,"AAO",{"$nulls":5},"Prioritized for psychiatric phenotypes"]
["PTPRU",1,29563028,29653325,1,"Hypomania",{"$nulls":5},"Prioritized for overlapping Li response and psychiatric phenotypes"]
["ZFYVE9",1,52608046,52812358,1,"Depression",{"$nulls":5},"LiResponse: dichotomized (response vs. no response)"]
["PRPF38A",1,52870236,52886511,1,"Depression",{"$nulls":5},"Continuous.LiResp: Alda A, excluding individuals with Alda B score > 4"]
["ZCCHC11",1,52873954,53019159,1,"Depression"]
["PPAP2B/PLPP3",1,56494747,56645301,1,"Alda_A"]
["DAB1",1,56994778,58546734,1,"Alda_B"]
["VAV3",1,108113782,108507766,1,"Hypomania"]
["TNR",1,175284330,175712906,1,"AAO"]
["IGFN1",1,201159953,201198080,1,"Mania"]
["NFASC",1,204797779,204991950,1,"Hypomania"]
["CR1L",1,207818458,207911761,1,"Depression"]
["ALK",2,29415640,30144432,2,"Depression","Mania"]
["LTBP1",2,33172039,33624576,1,"Depression"]
["NRXN1",2,50145643,51259674,3,"Depression","Hypomania","Substance"]
["RTN4",2,55199325,55339757,2,"Mania","Psychosis"]
["MAP4K4",2,102313312,102511149,1,"Hypomania"]
["IL1B",2,113587328,113594480,1,"AAO"]
["CNTNAP5",2,124025287,124915287,3,"LiResponse","Alda_B","Alda_Total"]
["LRP1B",2,140988992,142889270,2,"AAO","Mania"]
["SCN2A",2,166095912,166248818,1,"Continuous.LiResp"]
["LRP2",2,169127109,169362685,2,"Alda_B","Hypomania"]
["UBE2E3",2,181831975,181941312,1,"Hypomania"]
["NRP2",2,206546714,206662857,1,"Alcohol"]
["IKZF2",2,213864429,214017151,1,"Hypomania"]
["SP100",2,231280657,231408805,1,"Hypomania"]
["INPP5D",2,233924677,234116549,1,"Hypomania"]
["CNTN6",3,1134260,1445901,1,"Mania"]
["WNT7A",3,13816258,13880121,1,"Alda_B"]
["THRB",3,24158651,24536773,1,"Suicide"]
["RARB",3,25215823,25639423,1,"Suicide"]
["FBXL2",3,33318517,33445154,1,"Continuous.LiResp"]
["UBP1",3,33429828,33482863,1,"Continuous.LiResp"]
["CADPS",3,62384022,62861054,1,"Depression"]
["FAM19A1",3,68053359,68594776,1,"Psychosis"]
["ROBO2",3,75906695,77649964,3,"Alda_Total","Hypomania","Substance"]
["LSAMP",3,115521235,117716095,2,"AAO","Hypomania"]
["IGSF11",3,118619404,118864915,1,"Psychosis"]
["KALRN",3,123798870,124445172,1,"Mania"]
["IFT122",3,129158968,129239198,1,"Depression"]
["CLSTN2",3,139654027,140296239,1,"Psychosis"]
["CLDN11",3,170136653,170578169,1,"Hypomania"]
["FNDC3B",3,171757418,172119455,1,"Hypomania"]
["GC",4,71741693,71804041,1,"Alda_A"]
["SCD5",4,83550692,83720010,1,"Alcohol"]
["MAPK10",4,86936276,87515284,1,"Alcohol"]
["GRID2",4,92303622,93810157,2,"Alda_B","Alda_Total"]
["BMPR1B",4,95679119,96079599,1,"Depression"]
["UNC5C",4,96083655,96470357,1,"Depression"]
["BANK1",4,101411286,102074812,5,"Alda_A","Alda_B","Alda_Total","Hypomania","Continuous.LiResp"]
["CENPE",4,104026963,104119566,1,"Mania"]
["FAT4",4,126237554,126414087,1,"Hypomania"]
["RP11-804N13.1",5,21616371,21779631,1,"Suicide"]
["CDH12",5,21750673,22853622,2,"LiResponse","Suicide"]
["OSMR",5,38845960,38945698,1,"Mania"]
["THBS4",5,79287134,79379110,1,"Mania"]
["MSH3",5,79950467,80172279,1,"Mania"]
["RASGRF2",5,80960672,81230156,1,"Alda_B"]
["GPR98/ADGRV1",5,90529344,91164437,1,"Alda_Total"]
["SPOCK1",5,136310987,136934068,1,"Hypomania"]
["UBE2D2",5,138906016,139008018,1,"Hypomania"]
["NDFIP1",5,142108505,142154443,1,"Alda_A"]
["NR3C1",5,142657496,142815077,1,"Psychosis"]
["GM2A",5,150591711,150650001,1,"AAO"]
["EXOC2",6,485133,693117,1,"Substance"]
["LY86",6,6588341,6655216,1,"Mania"]
["DSP",6,7541575,7586717,2,"Alda_Total","Continuous.LiResp"]
["TXNDC5",6,7881483,8026646,1,"AAO"]
["RP3-510L9.1",6,11173685,11259332,2,"Hypomania","Mania"]
["JARID2",6,15246527,15522252,1,"Suicide"]
["BTN3A2",6,26365387,26378546,1,"Substance"]
["MDC1",6,30667584,30685666,1,"Hypomania"]
["HCG22",6,31021227,31027667,1,"Mania"]
["HLA-DMB",6,32934629,32941070,1,"Alda_Total"]
["MAPK14",6,35995488,36079013,1,"Hypomania"]
["RIMS1",6,72596406,73112845,2,"Hypomania","Alcohol"]
["UBE3D",6,83602117,83775560,1,"Hypomania"]
["MRAP2",6,84743475,84800600,1,"Hypomania"]
["GRIK2",6,101846664,102517958,1,"AAO"]
["RP3-399L15.3",6,114290865,114792869,1,"Substance"]
["TPD52L1",6,125440195,125585553,1,"Suicide"]
["LAMA2",6,129204342,129837714,1,"Hypomania"]
["TAB2",6,149539777,149732749,1,"Depression"]
["RPS6KA2",6,166409364,166906451,1,"LiResponse"]
["SDK1",7,3341080,4308632,1,"Hypomania"]
["DGKB",7,14184674,15014402,1,"Psychosis"]
["NOD1",7,30464143,30518400,1,"Substance"]
["NPSR1-AS1",7,34386124,34911194,2,"Depression","Suicide"]
["EPDR1",7,37723446,37991543,1,"Hypomania"]
["AMPH",7,38423305,38671167,1,"Depression"]
["SMURF1",7,98625061,98741723,1,"Hypomania"]
["DOCK4",7,111366166,111846466,1,"Hypomania"]
["CADPS2",7,122318425,122886759,1,"Alda_A"]
["DGKI",7,137065783,137531838,1,"Depression"]
["CNTNAP2",7,146116002,148420998,3,"LiResponse","Alda_Total","Mania"]
["PTK2B",8,27168999,27316903,1,"Mania"]
["NRG1",8,31496902,32622548,2,"Mania","Substance"]
["IKBKB",8,42128820,42189973,1,"Hypomania"]
["POLB",8,42195972,42229326,1,"Hypomania"]
["XKR4",8,56014949,56454613,4,"Depression","Mania","Psychosis","Substance"]
["TOX",8,58805418,59119208,1,"LiResponse"]
["TPD52",8,80870571,81143467,1,"Substance"]
["STK3",8,99413631,99955055,1,"Hypomania"]
["ANGPT1",8,108261721,108510283,1,"Depression"]
["DERL1",8,124025404,124054663,1,"Hypomania"]
["MTSS1",8,125563031,125740730,1,"Hypomania"]
["KANK1",9,470291,746105,1,"Mania"]
["NFIB",9,14081843,14398983,2,"Alda_B","Continuous.LiResp"]
["CLTA",9,36190853,36304778,2,"Hypomania","Alcohol"]
["RP11-613M10.9",9,37588410,38068684,1,"Hypomania"]
["SHB",9,37919131,38069210,1,"Hypomania"]
["PCSK5",9,78505560,78977255,1,"Mania"]
["S1PR3",9,91606362,91619925,1,"Mania"]
["WNK2",9,95947198,96082854,1,"Hypomania"]
["ADARB2",10,1177318,1737476,2,"Alda_B","Substance"]
["PRKCQ",10,6469105,6622263,1,"Substance"]
["CUBN",10,16865963,17171830,1,"Hypomania"]
["ITGB1",10,33189247,33294720,2,"Depression","Hypomania"]
["MARCH8",10,45950035,46090354,1,"Hypomania"]
["PCDH15",10,53802771,55627942,2,"LiResponse","Hypomania"]
["CTNNA3",10,67672276,69455927,2,"Hypomania","Continuous.LiResp"]
["AIFM2",10,70098223,70132934,1,"Alda_A"]
["SRGN",10,70847862,70864567,1,"Hypomania"]
["CDH23",10,73156691,73575702,1,"Substance"]
["NRG3",10,83635070,84746935,2,"Alcohol","Psychosis"]
["BMPR1A",10,86756601,86932838,2,"Alda_A","Continuous.LiResp"]
["PLCE1",10,95753746,96092580,1,"Substance"]
["ENTPD1",10,97471536,97637023,1,"Depression"]
["BLNK",10,97951458,98031344,1,"Depression"]
["BTRC",10,103113820,103317078,1,"Hypomania"]
["NRAP",10,115348475,115423886,1,"Depression"]
["GRK5",10,120967101,121215131,2,"AAO","Depression"]
["BAG3",10,121410882,121437331,1,"AAO"]
["ADAM12",10,127700950,128077024,1,"Psychosis"]
["DOCK1",10,128593978,129250781,1,"AAO"]
["DCHS1",11,6642556,6677085,1,"Mania"]
["PARVA",11,12398732,12552348,1,"Alcohol"]
["SPI1",11,47376411,47400127,1,"Alcohol"]
["INPPL1",11,71934745,71950149,1,"Hypomania"]
["FAT3",11,92352096,92896470,3,"LiResponse","Alda_Total","Depression"]
["CNTN5",11,98891683,100229616,1,"Psychosis"]
["NTM",11,131240373,132206716,1,"Mania"]
["OPCML",11,132284871,133402414,1,"Hypomania"]
["MGST1",12,16500076,16762193,1,"Mania"]
["VDR",12,47841537,47943048,2,"Alda_B","Hypomania"]
["WIBG",12,56295197,56326402,1,"Mania"]
["DGKA",12,56321103,56347811,1,"Mania"]
["FAM19A2",12,62102040,62672931,1,"Hypomania"]
["CHST11",12,104849073,105155792,1,"AAO"]
["FBXW8",12,117348761,117468953,1,"Depression"]
["SACS",13,23902965,24007841,1,"Depression"]
["DGKH",13,42614176,42830714,1,"Alcohol"]
["DLEU1",13,50656307,51297372,1,"Hypomania"]
["PCDH9",13,66302834,67230445,3,"Alda_B","Mania","Substance"]
["LMO7",13,76194570,76434004,1,"Mania"]
["ESR2",14,64550950,64804830,1,"Mania"]
["SPTB",14,65213002,65346601,1,"Mania"]
["ACTN1",14,68874143,68979440,1,"LiResponse"]
["TSHR",14,81421333,81612646,1,"Hypomania"]
["PPP2R5C",14,102228135,102394326,1,"Hypomania"]
["UNC13C",15,54305101,54920806,1,"Depression"]
["RAB27A",15,55202966,55319113,1,"Alda_A"]
["RP11-219B17.1",15,60771377,60922836,1,"Mania"]
["TLN2",15,62682725,63136830,1,"Depression"]
["AKAP13",15,85923802,86292586,1,"Mania"]
["CPPED1",16,12756919,12897874,2,"AAO","Depression"]
["XYLT1",16,17195626,17564738,1,"Hypomania"]
["GNAO1",16,56191347,56357457,1,"LiResponse"]
["CDH8",16,61681146,62070939,1,"Continuous.LiResp"]
["HAS3",16,69105564,69118719,3,"Alda_A","Alda_Total","Continuous.LiResp"]
["WWOX",16,78133310,79246564,1,"AAO"]
["CDH13",16,82660408,83830204,2,"Hypomania","Psychosis"]
["NTN1",17,8924859,9147317,1,"Hypomania"]
["TMC6",17,78110458,78132407,1,"LiResponse"]
["LAMA1",18,6941743,7117813,1,"Depression"]
["PTPRM",18,7566780,8406859,3,"Hypomania","Mania","Substance"]
["PIK3C3",18,39535171,39667794,1,"Hypomania"]
["DCC",18,49866542,51057784,1,"Depression"]
["CDH20",18,59000815,59223006,1,"Psychosis"]
["PHLPP1",18,60382672,60647666,1,"Depression"]
["CDH19",18,64168320,64271375,1,"Continuous.LiResp"]
["MBP",18,74690783,74845639,1,"AAO"]
["ZNF675",19,23708433,23870022,1,"AAO"]
["ACTN4",19,39138289,39222223,1,"AAO"]
["AKT2",19,40736224,40791443,1,"AAO"]
["PLD3",19,40854363,40886346,1,"AAO"]
["AXL",19,41725108,41767671,1,"Hypomania"]
["ZNF175",19,52074551,52092991,1,"AAO"]
["PAK7",20,9518036,9819689,1,"Substance"]
["PKIG",20,43160426,43252888,1,"Continuous.LiResp"]
["ADA",20,43248163,43280874,1,"Continuous.LiResp"]
["NCAM2",21,22370633,22915650,1,"Substance"]
["ADAMTS5",21,26917912,26966513,2,"Alda_B","Alda_Total"]
["DSCAM",21,41382926,42219065,1,"Psychosis"]
["RAC2",22,37621301,37640488,1,"Hypomania"]
["FAM19A5",22,48489460,48850912,1,"LiResponse"]

{"sheet":"Table2","index":1,"n_rows":141,"n_cols":9,"rows_kept":141,"cut":false,"hidden":false,"merged":[]}
["Pathways overrepresented in the PPI network created for dichotomous and continuous Li response phenotypes in ConLiGen"]
[]
["Pathway (including network linker genes, excluding disease-specific terms)","N_Term","Overlap (at least 2)","% from N (>3)","FDR (<0.05)","Genes",null,null,"Pathway database"]
["Adherens junction(K)",71,6,{"$f":"(C4*100)/B4","v":8.4507042253521121},1.3784999999999999e-05,"TCF7,CTNNA3,RAC1,ACTN1,RHOA,CTNNB1",null,null,"K: KEGG"]
["E-cadherin signaling in keratinocytes(N)",21,4,19.047619047619047,3.0723999999999999e-05,"RAC1,JUP,RHOA,CTNNB1",null,null,"N: NCI-Nature"]
["Leukocyte transendothelial migration(K)",114,6,5.2631578947368425,3.0723999999999999e-05,"PIK3R2,CTNNA3,RAC1,ACTN1,RHOA,CTNNB1",null,null,"B: BioCarta"]
["Neurotrophin signaling pathway(K)",119,6,5.0420168067226889,3.0723999999999999e-05,"PIK3R2,RPS6KA2,RAC1,MAP2K1,NFKB1,RHOA",null,null,"P: Panther"]
["Sphingolipid signaling pathway(K)",119,6,5.0420168067226889,3.0723999999999999e-05,"PIK3R2,ADORA1,RAC1,MAP2K1,NFKB1,RHOA",null,null,"R: Reactome"]
["Bacterial invasion of epithelial cells(K)",77,5,6.4935064935064934,5.2543999999999997e-05,"PIK3R2,CTNNA3,RAC1,RHOA,CTNNB1"]
["N-cadherin signaling events(N)",34,4,{"$f":"(C10*100)/B10","v":11.764705882352942},5.7720000000000003e-05,"RAC1,JUP,RHOA,CTNNB1"]
["E-cadherin signaling in the nascent adherens junction(N)",36,4,11.111111111111111,6.2314e-05,"RAC1,JUP,RHOA,CTNNB1"]
["Posttranslational regulation of adherens junction stability and dissassembly(N)",48,4,8.3333333333333339,0.00017726999999999999,"RAC1,DSP,JUP,CTNNB1"]
["ucalpain and friends in cell spread(B)",15,3,20,0.00019429000000000001,"RAC1,ACTN1,RHOA"]
["role of mal in rho-mediated activation of srf(B)",16,3,18.75,0.00021398000000000001,"RAC1,MAP2K1,RHOA"]
["Focal adhesion(K)",201,6,2.9850746268656718,0.00022905000000000001,"PIK3R2,RAC1,MAP2K1,ACTN1,RHOA,CTNNB1"]
["S1P1 pathway(N)",18,3,16.666666666666668,0.00025805000000000001,"RAC1,RHOA,GNAO1"]
["Signaling events mediated by focal adhesion kinase(N)",61,4,6.557377049180328,0.00029451,"RAC1,MAP2K1,ACTN1,RHOA"]
["LPA receptor mediated events(N)",63,4,6.3492063492063489,0.00031159999999999998,"RAC1,NFKB1,RHOA,GNAO1"]
["Ras Pathway(P)",63,4,6.3492063492063489,0.00031159999999999998,"RPS6KA2,RAC1,MAP2K1,RHOA"]
["influence of ras and rho proteins on g1 to s transition(B)",22,3,13.636363636363637,0.00038528,"RAC1,MAP2K1,RHOA"]
["Signaling pathways regulating pluripotency of stem cells(K)",143,5,3.4965034965034967,0.00042462000000000001,"TCF7,PIK3R2,MAP2K1,CTNNB1,BMPR1A"]
["Prolactin signaling pathway(K)",70,4,5.7142857142857144,0.00042462000000000001,"PIK3R2,MAP2K1,ESR1,NFKB1"]
["Cell junction organization(R)",71,4,5.6338028169014081,0.00042462000000000001,"CDH8,JUP,ACTN1,CDH12"]
["Nongenotropic Androgen signaling(N)",25,3,12,0.00044185999999999997,"RAC1,MAP2K1,GNAO1"]
["S1P3 pathway(N)",25,3,12,0.00044185999999999997,"RAC1,RHOA,GNAO1"]
["S1P2 pathway(N)",26,3,11.538461538461538,0.00049616000000000005,"RAC1,RHOA,GNAO1"]
["Integrin signalling pathway(P)",158,5,3.1645569620253164,0.00053167000000000004,"PIK3R2,RAC1,MAP2K1,ACTN1,RHOA"]
["Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)(N)",80,4,5,0.00055539000000000001,"RAC1,MAP2K1,RHOA,CTNNB1"]
["T cell activation(P)",81,4,4.9382716049382713,0.00055539000000000001,"PIK3R2,RAC1,MAP2K1,NFKB1"]
["CXCR4-mediated signaling events(N)",81,4,4.9382716049382713,0.00055539000000000001,"BLK,RAC1,RHOA,GNAO1"]
["B cell receptor signaling pathway(K)",82,4,4.8780487804878048,0.00055539000000000001,"PIK3R2,RAC1,MAP2K1,NFKB1"]
["erk and pi-3 kinase are necessary for collagen binding in corneal epithelia(B)",30,3,10,0.00061921999999999997,"MAP2K1,ACTN1,RHOA"]
["trefoil factors initiate mucosal healing(B)",31,3,9.67741935483871,0.00068201999999999998,"MAP2K1,RHOA,CTNNB1"]
["Syndecan-4-mediated signaling events(N)",32,3,9.375,0.00074885000000000001,"RAC1,ACTN1,RHOA"]
["Netrin-mediated signaling events(N)",32,3,9.375,0.00074885000000000001,"RAC1,MAP2K1,RHOA"]
["Signaling by VEGF(R)",95,4,4.2105263157894735,0.00086859000000000003,"PIK3R2,RAC1,JUP,RHOA"]
["Cadherin signaling pathway(P)",100,4,4,0.0010568000000000001,"PCDH15,CTNNB1,FAT3,CDH19"]
["Melanogenesis(K)",101,4,3.9603960396039604,0.0010977000000000001,"TCF7,MAP2K1,GNAO1,CTNNB1"]
["T cell receptor signaling pathway(K)",104,4,3.8461538461538463,0.0011215999999999999,"PIK3R2,MAP2K1,NFKB1,RHOA"]
["Toll-like receptor signaling pathway(K)",104,4,3.8461538461538463,0.0011215999999999999,"PIK3R2,RAC1,MAP2K1,NFKB1"]
["Class I PI3K signaling events(N)",40,3,7.5,0.0011215999999999999,"BLK,RAC1,RHOA"]
["Signaling by NTRK1 (TRKA)(R)",107,4,3.7383177570093458,0.0011967,"PIK3R2,RPS6KA2,MAP2K1,RHOA"]
["Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway(P)",108,4,3.7037037037037037,0.0012398000000000001,"CHRM3,ADORA1,RHOA,GNAO1"]
["Stabilization and expansion of the E-cadherin adherens junction(N)",42,3,7.1428571428571432,0.0012568,"ACTN1,RHOA,CTNNB1"]
["Plasma membrane estrogen receptor signaling(N)",42,3,7.1428571428571432,0.0012568,"ESR1,RHOA,GNAO1"]
["RHO GTPases activate KTN1(R)",8,2,25,0.0012568,"RAC1,RHOA"]
["S1P5 pathway(N)",8,2,25,0.0012568,"RHOA,GNAO1"]
["Cholinergic synapse(K)",113,4,3.5398230088495577,0.0012620999999999999,"CHRM3,PIK3R2,MAP2K1,GNAO1"]
["Beta-catenin independent WNT signaling(R)",113,4,3.5398230088495577,0.0012620999999999999,"RAC1,RHOA,GNAO1,CTNNB1"]
["Integrin-linked kinase signaling(N)",45,3,6.666666666666667,0.0013568,"RAC1,ACTN1,CTNNB1"]
["PDGFR-beta signaling pathway(N)",120,4,3.3333333333333335,0.0015847999999999999,"BLK,RAC1,MAP2K1,RHOA"]
["Thyroid hormone signaling pathway(K)",121,4,3.3057851239669422,0.0016352999999999999,"PIK3R2,MAP2K1,ESR1,CTNNB1"]
["Osteoclast differentiation(K)",128,4,3.125,0.0020219999999999999,"PIK3R2,RAC1,MAP2K1,NFKB1"]
["Relaxin signaling pathway(K)",129,4,3.1007751937984498,0.0020701999999999999,"PIK3R2,MAP2K1,NFKB1,GNAO1"]
["Thromboxane A2 receptor signaling(N)",54,3,5.5555555555555554,0.0020701999999999999,"BLK,RAC1,RHOA"]
["RHO GTPases activate IQGAPs(R)",11,2,18.181818181818183,0.0020701999999999999,"RAC1,CTNNB1"]
["VEGF signaling pathway(K)",59,3,5.0847457627118642,0.0024862,"PIK3R2,RAC1,MAP2K1"]
["Endothelins(N)",62,3,4.838709677419355,0.0028698,"RAC1,MAP2K1,GNAO1"]
["Signaling events mediated by VEGFR1 and VEGFR2(N)",63,3,4.7619047619047619,0.0030056000000000002,"MAP2K1,RHOA,CTNNB1"]
["S1P4 pathway(N)",14,2,14.285714285714286,0.0031608999999999999,"RHOA,GNAO1"]
["BCR signaling pathway(N)",65,3,4.615384615384615,0.0032894999999999999,"RAC1,MAP2K1,NFKB1"]
["Interleukin-17 signaling(R)",67,3,4.4776119402985071,0.0032921000000000001,"RPS6KA2,MAP2K1,NFKB1"]
["Arf6 downstream pathway(N)",15,2,13.333333333333334,0.0032921000000000001,"RAC1,RHOA"]
["Fc epsilon RI signaling pathway(K)",68,3,4.4117647058823533,0.0032921000000000001,"PIK3R2,RAC1,MAP2K1"]
["Wnt signaling pathway(K)",160,4,2.5,0.0032921000000000001,"TCF7,RAC1,RHOA,CTNNB1"]
["AP-1 transcription factor network(N)",70,3,4.2857142857142856,0.0032921000000000001,"GATA2,ESR1,CTNNB1"]
["role of pi3k subunit p85 in regulation of actin organization and cell migration(B)",16,2,12.5,0.0032921000000000001,"RAC1,RHOA"]
["EPHA2 forward signaling(N)",18,2,11.111111111111111,0.0041530999999999998,"RAC1,RHOA"]
["map kinase inactivation of smrt corepressor(B)",18,2,11.111111111111111,0.0041530999999999998,"RAC1,MAP2K1"]
["RHO GTPases activate CIT(R)",19,2,10.526315789473685,0.0046198000000000003,"RAC1,RHOA"]
["L1CAM interactions(R)",82,3,3.6585365853658538,0.0051275000000000001,"RPS6KA2,RAC1,MAP2K1"]
["Taste transduction(K)",86,3,3.4883720930232558,0.0058735999999999997,"CHRM3,CALHM1,SCN2A"]
["ras signaling pathway(B)",22,2,9.0909090909090917,0.0061637999999999997,"RAC1,RHOA"]
["ccr3 signaling in eosinophils(B)",22,2,{"$f":"(C74*100)/B74","v":9.0909090909090917},0.0061637999999999997,"MAP2K1,RHOA"]
["Nephrin family interactions(R)",22,2,9.0909090909090917,0.0061637999999999997,"PIK3R2,ACTN1"]
["p75 NTR receptor-mediated signalling(R)",88,3,3.4090909090909092,0.0062708,"RAC1,NFKB1,RHOA"]
["PD-L1 expression and PD-1 checkpoint pathway in cancer(K)",89,3,3.3707865168539324,0.0064149000000000003,"PIK3R2,MAP2K1,NFKB1"]
["links between pyk2 and map kinases(B)",23,2,8.695652173913043,0.0064149000000000003,"RAC1,MAP2K1"]
["Signaling events mediated by PRL(N)",23,2,8.695652173913043,0.0064149000000000003,"RAC1,RHOA"]
["Ephrin B reverse signaling(N)",24,2,8.3333333333333339,0.0064149000000000003,"BLK,RAC1"]
["fmlp induced chemokine gene expression in hmc-1 cells(B)",24,2,8.3333333333333339,0.0064149000000000003,"RAC1,MAP2K1"]
["ras-independent pathway in nk cell-mediated cytotoxicity(B)",25,2,8,0.0064149000000000003,"RAC1,MAP2K1"]
["Fc gamma R-mediated phagocytosis(K)",97,3,3.0927835051546393,0.0064149000000000003,"PIK3R2,RAC1,MAP2K1"]
["bcr signaling pathway(B)",26,2,7.6923076923076925,0.0064149000000000003,"RAC1,MAP2K1"]
["mcalpain and friends in cell motility(B)",26,2,7.6923076923076925,0.0064149000000000003,"RAC1,MAP2K1"]
["AGE-RAGE signaling pathway in diabetic complications(K)",100,3,3,0.0067571999999999997,"PIK3R2,RAC1,NFKB1"]
["Progesterone-mediated oocyte maturation(K)",100,3,3,0.0067571999999999997,"PIK3R2,RPS6KA2,MAP2K1"]
["Lissencephaly gene (LIS1) in neuronal migration and development(N)",28,2,7.1428571428571432,0.0074156999999999999,"RAC1,RHOA"]
["Osteopontin-mediated events(N)",29,2,6.8965517241379306,0.0079419,"RAC1,NFKB1"]
["Insulin resistance(K)",108,3,2.7777777777777777,0.0083932,"PIK3R2,RPS6KA2,NFKB1"]
["GPVI-mediated activation cascade(R)",30,2,6.666666666666667,0.0084852999999999994,"RAC1,RHOA"]
["Nectin adhesion pathway(N)",30,2,6.666666666666667,0.0084852999999999994,"RAC1,CTNNB1"]
["Regulation of p38-alpha and p38-beta(N)",31,2,6.4516129032258061,0.0090457999999999997,"BLK,RAC1"]
["amb2 Integrin signaling(N)",31,2,6.4516129032258061,0.0090457999999999997,"NFKB1,RHOA"]
["phospholipids as signalling intermediaries(B)",31,2,6.4516129032258061,0.0090457999999999997,"RAC1,MAP2K1"]
["role of egf receptor transactivation by gpcrs in cardiac hypertrophy(B)",31,2,6.4516129032258061,0.0090457999999999997,"MAP2K1,RHOA"]
["EPHA forward signaling(N)",31,2,6.4516129032258061,0.0090457999999999997,"BLK,RHOA"]
["TNF signaling pathway(K)",112,3,2.6785714285714284,0.0092951000000000006,"PIK3R2,MAP2K1,NFKB1"]
["Noncanonical Wnt signaling pathway(N)",32,2,6.25,0.0096231000000000008,"RAC1,RHOA"]
["integrin signaling pathway(B)",33,2,6.0606060606060606,0.010200000000000001,"ACTN1,RHOA"]
["angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling(B)",33,2,6.0606060606060606,0.010200000000000001,"RAC1,MAP2K1"]
["IL2 signaling events mediated by PI3K(N)",35,2,5.7142857142857144,0.0115,"RAC1,NFKB1"]
["CXCR3-mediated signaling events(N)",35,2,5.7142857142857144,0.0115,"MAP2K1,GNAO1"]
["ErbB2/ErbB3 signaling events(N)",37,2,5.4054054054054053,0.012200000000000001,"RAC1,MAP2K1"]
["Signaling events mediated by HDAC Class II(N)",38,2,5.2631578947368425,0.012200000000000001,"GATA2,ESR1"]
["EPHB forward signaling(N)",38,2,5.2631578947368425,0.012200000000000001,"RAC1,MAP2K1"]
["Signaling events regulated by Ret tyrosine kinase(N)",39,2,5.1282051282051286,0.012200000000000001,"RAC1,RHOA"]
["FOXM1 transcription factor network(N)",40,2,5,0.012200000000000001,"MAP2K1,ESR1"]
["Sensory perception of taste(R)",42,2,4.7619047619047619,0.012200000000000001,"CALHM1,SCN2A"]
["PAR1-mediated thrombin signaling events(N)",43,2,4.6511627906976747,0.012200000000000001,"RHOA,GNAO1"]
["FOXA1 transcription factor network(N)",44,2,4.5454545454545459,0.012200000000000001,"ESR1,NFIB"]
["DAP12 interactions(R)",44,2,4.5454545454545459,0.012200000000000001,"PIK3R2,RAC1"]
["Integrins in angiogenesis(N)",47,2,4.2553191489361701,0.0135,"RAC1,RHOA"]
["Apoptotic execution phase(R)",47,2,4.2553191489361701,0.0135,"DSP,CTNNB1"]
["Hedgehog signaling events mediated by Gli proteins(N)",48,2,4.166666666666667,0.0141,"MAP2K1,GNAO1"]
["Ceramide signaling pathway(N)",48,2,4.166666666666667,0.0141,"MAP2K1,NFKB1"]
["t cell receptor signaling pathway(B)",49,2,4.0816326530612246,0.0146,"RAC1,MAP2K1"]
["Angiopoietin receptor Tie2-mediated signaling(N)",50,2,4,0.0152,"RAC1,NFKB1"]
["Class IB PI3K non-lipid kinase events(N)",3,1,33.333333333333336,0.015599999999999999,"MAP2K1"]
["SHP2 signaling(N)",51,2,3.9215686274509802,0.015800000000000002,"MAP2K1,RHOA"]
["Signaling by PTK6(R)",51,2,3.9215686274509802,0.015800000000000002,"RAC1,RHOA"]
["Signaling events mediated by PTP1B(N)",52,2,3.8461538461538463,0.016400000000000001,"BLK,RHOA"]
["Sensory processing of sound by outer hair cells of the cochlea(R)",53,2,3.7735849056603774,0.017000000000000001,"PCDH15,EPB41L3"]
["mapkinase signaling pathway(B)",53,2,3.7735849056603774,0.017000000000000001,"RAC1,MAP2K1"]
["Senescence-Associated Secretory Phenotype (SASP)(R)",54,2,3.7037037037037037,0.017600000000000001,"RPS6KA2,NFKB1"]
["IL2-mediated signaling events(N)",54,2,3.7037037037037037,0.017600000000000001,"MAP2K1,RHOA"]
["RAC1 signaling pathway(N)",54,2,3.7037037037037037,0.017600000000000001,"RAC1,CTNNB1"]
["Regulation of lipolysis in adipocytes(K)",56,2,3.5714285714285716,0.0189,"PIK3R2,ADORA1"]
["Signaling events mediated by HDAC Class I(N)",56,2,3.5714285714285716,0.0189,"GATA2,NFKB1"]
["B cell activation(P)",59,2,3.3898305084745761,0.020899999999999998,"RAC1,MAP2K1"]
["Long-term depression(K)",60,2,3.3333333333333335,0.021600000000000001,"MAP2K1,GNAO1"]
["Neurotrophic factor-mediated Trk receptor signaling(N)",60,2,3.3333333333333335,0.021600000000000001,"RAC1,MAP2K1"]
["Fc-epsilon receptor I signaling in mast cells(N)",62,2,3.225806451612903,0.0229,"MAP2K1,NFKB1"]
["Semaphorin interactions(R)",63,2,3.1746031746031744,0.023599999999999999,"RAC1,RHOA"]
["GnRH secretion(K)",64,2,3.125,0.024400000000000002,"PIK3R2,MAP2K1"]
["Cytosolic sensors of pathogen-associated DNA (R)",64,2,3.125,0.024400000000000002,"NFKB1,CTNNB1"]
["Angiogenesis(P)",66,2,3.0303030303030303,0.0258,"PIK3R2,RHOA"]
["Sensory processing of sound by inner hair cells of the cochlea(R)",67,2,{"$f":"(C138*100)/B138","v":2.9850746268656718},0.026599999999999999,"PCDH15,EPB41L3"]
["Long-term potentiation(K)",67,2,2.9850746268656718,0.026599999999999999,"RPS6KA2,MAP2K1"]
["Regulation of nuclear beta catenin signaling and target gene transcription(N)",79,2,2.5316455696202533,0.028299999999999999,"TCF7,CTNNB1"]
["EGFR tyrosine kinase inhibitor resistance(K)",79,2,2.5316455696202533,0.028299999999999999,"PIK3R2,MAP2K1"]

{"sheet":"Table3","index":2,"n_rows":30,"n_cols":5,"rows_kept":30,"cut":false,"hidden":false,"merged":[[3,0,3,4],[11,0,11,4]]}
["Overrepresented gene sets within ImmuneSet associations for AAO in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["DEG.twoside","Brain_Cerebellar_Hemisphere",8319,14,0.041399860966248599]
["Curated_gene_sets","KEGG_FOCAL_ADHESION",198,4,0.040069932305069146]
["GO_bp","GO_APOPTOTIC_PROCESS",1943,10,0.0040665351733826013]
["GO_bp","GO_REGULATION_OF_CELL_DEATH",1686,9,0.0069896343076452762]
["GO_bp","GO_NEGATIVE_REGULATION_OF_CELL_DEATH",1000,7,0.015697728390715083]
["GO_bp","GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION",70,3,0.031838285579301732]
["GO_bp","GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND",71,3,0.031838285579301732]
["Mapped + eQTL genes"]
["GO_bp","GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY",1391,14,0.028000000000000001]
["GO_bp","GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS",716,10,0.028000000000000001]
["GO_bp","GO_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS",1232,13,0.028000000000000001]
["GO_bp","GO_JNK_CASCADE",212,6,0.028000000000000001]
["GO_bp","GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY",747,10,0.028000000000000001]
["GO_bp","GO_HOMEOSTATIC_PROCESS",1896,16,0.028000000000000001]
["GO_bp","GO_REGULATION_OF_CELL_DEATH",1686,15,0.028000000000000001]
["GO_bp","GO_APOPTOTIC_PROCESS",1943,16,0.028000000000000001]
["GO_bp","GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE",235,6,0.028000000000000001]
["GO_bp","GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION",1733,15,0.028000000000000001]
["GO_bp","GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY",503,8,0.035700000000000003]
["GO_bp","GO_NEGATIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS",1604,14,0.036299999999999999]
["GO_bp","GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING",261,6,0.036299999999999999]
["GO_bp","GO_PROTEIN_KINASE_B_SIGNALING",263,6,0.036299999999999999]
[]
[]
["DEG: differentially expressed gene"]
["GO_bp: gene ontology biological process"]

{"sheet":"Table4","index":3,"n_rows":34,"n_cols":5,"rows_kept":34,"cut":false,"hidden":false,"merged":[[3,0,3,4],[15,0,15,4]]}
["Overrepresented gene sets within ImmuneSet associations for the number of depressive episodes in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,22,9.6159718976271502e-05]
["DEG.twoside","Brain_Cortex",8094,20,0.0039767139426568603]
["DEG.twoside","Brain_Anterior_cingulate_cortex_BA24",8789,20,0.0141760827444815]
["GO_bp","GO_SYNAPTIC_VESICLE_CYCLE",190,5,0.016676823254932215]
["GO_bp","GO_SYNAPTIC_SIGNALING",706,7,0.041045552878698432]
["GO_bp","GO_NEURON_DEVELOPMENT",1092,8,0.041045552878698432]
["GO_bp","GO_ANTERIOR_POSTERIOR_AXON_GUIDANCE",7,2,0.041045552878698432]
["GO_bp","GO_CIRCULATORY_SYSTEM_DEVELOPMENT",1134,8,0.041045552878698432]
["GO_bp","GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION",575,6,0.041045552878698432]
["GO_bp","GO_SIGNAL_RELEASE_FROM_SYNAPSE",170,4,0.041045552878698432]
["GO_bp","GO_DENSE_CORE_GRANULE_EXOCYTOSIS",9,2,0.041045552878698432]
["Mapped + eQTL genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,26,0.00183136596560483]
["DEG.twoside","Brain_Cortex",8094,24,0.031563712742357003]
["GO_cc","GO_NEURON_PART",1703,13,0.00095500000000000001]
["GO_cc","GO_SCHAFFER_COLLATERAL__CA1_SYNAPSE",82,4,0.0038800000000000002]
["GO_cc","GO_CELL_JUNCTION",1273,10,0.00513]
["GO_cc","GO_NEURON_PROJECTION",1296,10,0.00513]
["GO_cc","GO_SYNAPSE",1168,9,0.011599999999999999]
["GO_cc","GO_NUCLEAR_MEMBRANE",299,5,0.0155]
["GO_cc","GO_PRESYNAPTIC_ACTIVE_ZONE",70,3,0.0246]
["GO_cc","GO_CELL_PROJECTION_PART",1434,9,0.0327]
["GO_cc","GO_AXON",600,6,0.0327]
["GO_cc","GO_SYNAPTIC_MEMBRANE",427,5,0.0453]
["GO_cc","GO_SYNAPSE_PART",931,7,0.0453]
[]
[]
["DEG: differentially expressed gene"]
["GO_bp: gene ontology biological process"]
["GO_cc: gene ontology cellular compartment"]

{"sheet":"Table5","index":4,"n_rows":85,"n_cols":5,"rows_kept":85,"cut":false,"hidden":false,"merged":[[3,0,3,4],[40,0,40,4]]}
["Overrepresented gene sets within ImmuneSet associations for the number of hypomanic episodes in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,35,7.3399999999999995e-05]
["DEG.twoside","Brain_Cortex",8094,34,0.00050699999999999996]
["DEG.twoside","Brain_Caudate_basal_ganglia",8801,35,0.0011900000000000001]
["DEG.twoside","Brain_Putamen_basal_ganglia",9290,36,0.0014499999999999999]
["DEG.twoside","Brain_Nucleus_accumbens_basal_ganglia",8591,33,0.0059699999999999996]
["DEG.twoside","Brain_Cerebellum",8270,32,0.0074200000000000004]
["DEG.twoside","Brain_Cerebellar_Hemisphere",8319,32,0.0083899999999999999]
["DEG.twoside","Brain_Hippocampus",9210,34,0.0098399999999999998]
["DEG.twoside","Brain_Hypothalamus",8164,31,0.0155]
["DEG.twoside","Brain_Anterior_cingulate_cortex_BA24",8789,32,0.025600000000000001]
["DEG.twoside","Brain_Amygdala",9265,33,0.0292]
["Canonical_Pathways","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",114,6,0.00060002913086305799]
["Canonical_Pathways","REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES",468,9,0.00093984543464509978]
["Canonical_Pathways","REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM",11,3,0.0019333626090543134]
["Canonical_Pathways","REACTOME_ADAPTIVE_IMMUNE_SYSTEM",747,10,0.0032848810658437973]
["Canonical_Pathways","KEGG_CELL_ADHESION_MOLECULES_CAMS",130,5,0.0053424871143986936]
["Canonical_Pathways","REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES",24,3,0.0072936395467067148]
["Canonical_Pathways","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",75,4,0.0072936395467067148]
["Canonical_Pathways","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",79,4,0.008363073960871022]
["Canonical_Pathways","REACTOME_HEMOSTASIS",613,8,0.012347153787572736]
["Canonical_Pathways","REACTOME_CELL_JUNCTION_ORGANIZATION",92,4,0.012347153787572736]
["Canonical_Pathways","REACTOME_DOWNSTREAM_TCR_SIGNALING",94,4,0.012347153787572736]
["Canonical_Pathways","REACTOME_SIGNALING_BY_INTERLEUKINS",628,8,0.012347153787572736]
["Canonical_Pathways","REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE",95,4,0.012347153787572736]
["Canonical_Pathways","REACTOME_TRIF_TICAM1_MEDIATED_TLR4_SIGNALING",97,4,0.012787634149417004]
["Canonical_Pathways","REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM",850,9,0.014817012476825374]
["Canonical_Pathways","REACTOME_SIGNALING_BY_VEGF",105,4,0.01597299714544435]
["Canonical_Pathways","REACTOME_TCR_SIGNALING",115,4,0.02021851432826989]
["Canonical_Pathways","REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION",370,6,0.023653232037024043]
["Canonical_Pathways","REACTOME_CELL_CELL_COMMUNICATION",129,4,0.025778927497434097]
["Canonical_Pathways","REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING",131,4,0.026545842670092083]
["Canonical_Pathways","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",134,4,0.028130621018933329]
["Canonical_Pathways","REACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO",10,2,0.028596509917127668]
["Canonical_Pathways","REACTOME_DSCAM_INTERACTIONS",11,2,0.033561182802101255]
["Canonical_Pathways","KEGG_MAPK_SIGNALING_PATHWAY",267,5,0.033561182802101255]
["Canonical_Pathways","REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS",59,3,0.03547798525201596]
["Mapped + eQTL genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,49,9.6923268619710795e-06]
["DEG.twoside","Brain_Caudate_basal_ganglia",8801,51,4.7095926165789002e-05]
["DEG.twoside","Brain_Cortex",8094,48,7.2937034552912299e-05]
["DEG.twoside","Brain_Putamen_basal_ganglia",9290,52,0.00010326519715899101]
["DEG.twoside","Brain_Nucleus_accumbens_basal_ganglia",8591,48,0.00046251960783739998]
["DEG.twoside","Brain_Anterior_cingulate_cortex_BA24",8789,48,0.00091562769777772299]
["DEG.twoside","Brain_Amygdala",9265,49,0.0017417820994591201]
["DEG.twoside","Brain_Hypothalamus",8164,44,0.0043673942710235397]
["DEG.twoside","Brain_Cerebellar_Hemisphere",8319,44,0.0070857172421465399]
["DEG.twoside","Brain_Hippocampus",9210,47,0.0083291962119009001]
["DEG.twoside","Brain_Cerebellum",8270,43,0.0139592638813619]
["Canonical_Pathways","KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION",114,6,0.0022100000000000002]
["Canonical_Pathways","REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM",11,3,0.0041599999999999996]
["Canonical_Pathways","REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES",468,9,0.0061599999999999997]
["Canonical_Pathways","REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM",850,11,0.016500000000000001]
["Canonical_Pathways","KEGG_CELL_ADHESION_MOLECULES_CAMS",130,5,0.016500000000000001]
["Canonical_Pathways","REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES",24,3,0.016500000000000001]
["Canonical_Pathways","REACTOME_ADAPTIVE_IMMUNE_SYSTEM",747,10,0.0167]
["Canonical_Pathways","KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY",75,4,0.0167]
["Canonical_Pathways","KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY",79,4,0.0167]
["Canonical_Pathways","REACTOME_TOLL_LIKE_RECEPTOR_CASCADES",153,5,0.0167]
["Canonical_Pathways","REACTOME_SIGNALING_BY_INTERLEUKINS",628,9,0.0167]
["Canonical_Pathways","REACTOME_CELL_JUNCTION_ORGANIZATION",92,4,0.026599999999999999]
["Canonical_Pathways","REACTOME_DOWNSTREAM_TCR_SIGNALING",94,4,0.026599999999999999]
["Canonical_Pathways","REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE",95,4,0.026599999999999999]
["Canonical_Pathways","REACTOME_TRIF_TICAM1_MEDIATED_TLR4_SIGNALING",97,4,0.0269]
["Canonical_Pathways","REACTOME_INNATE_IMMUNE_SYSTEM",1041,11,0.027199999999999998]
["Canonical_Pathways","REACTOME_SIGNALING_BY_VEGF",105,4,0.032099999999999997]
["Canonical_Pathways","REACTOME_SIGNALING_BY_RHO_GTPASES",447,7,0.038600000000000002]
["Canonical_Pathways","REACTOME_TCR_SIGNALING",115,4,0.040300000000000002]
["Canonical_Pathways","REACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO",10,2,0.040300000000000002]
["Canonical_Pathways","REACTOME_HEMOSTASIS",613,8,0.041500000000000002]
["Canonical_Pathways","REACTOME_DSCAM_INTERACTIONS",11,2,0.044699999999999997]
["Canonical_Pathways","REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE",127,4,0.045199999999999997]
["Canonical_Pathways","REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS",54,3,0.045199999999999997]
["Canonical_Pathways","REACTOME_CELL_CELL_COMMUNICATION",129,4,0.045199999999999997]
["Canonical_Pathways","KEGG_AXON_GUIDANCE",129,4,0.045199999999999997]
["Canonical_Pathways","REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING",131,4,0.045199999999999997]
["Canonical_Pathways","KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY",131,4,0.045199999999999997]
["Canonical_Pathways","KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS",134,4,0.047500000000000001]
["Canonical_Pathways","REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS",59,3,0.049399999999999999]
[]
[]
["DEG: differentially expressed gene"]

{"sheet":"Table6","index":5,"n_rows":40,"n_cols":5,"rows_kept":40,"cut":false,"hidden":false,"merged":[[3,0,3,4],[21,0,21,4]]}
["Overrepresented gene sets within ImmuneSet associations for the number of manic episodes in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["DEG.twoside","Brain_Spinal_cord_cervical_c-1",7047,17,0.0203336934686736]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,18,0.022948942815470399]
["DEG.twoside","Brain_Cortex",8094,18,0.033519081409750899]
["GO_bp","GO_NEUROGENESIS",1591,12,0.00030017369123326311]
["GO_bp","GO_NEURON_DIFFERENTIATION",1341,11,0.00030017369123326311]
["GO_bp","GO_NEURON_DEVELOPMENT",1092,10,0.00030017369123326311]
["GO_bp","GO_CELLULAR_COMPONENT_MORPHOGENESIS",1111,10,0.00030017369123326311]
["GO_bp","GO_NEURON_RECOGNITION",47,4,0.00030017369123326311]
["GO_bp","GO_BIOLOGICAL_ADHESION",1396,10,0.0016967938985788665]
["GO_bp","GO_REGULATION_OF_CELL_DEVELOPMENT",928,8,0.0054511445618335083]
["GO_bp","GO_CELL_PART_MORPHOGENESIS",673,7,0.0061094156551901729]
["GO_bp","GO_CELL_RECOGNITION",144,4,0.014917159207509306]
["GO_bp","GO_CIRCULATORY_SYSTEM_DEVELOPMENT",1134,8,0.016399762214041536]
["GO_bp","GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",163,4,0.019846859251147472]
["GO_bp","GO_TAXIS",631,6,0.033685988838169999]
["GWAS_Catalog","Serum thyroid-stimulating hormone levels",26,3,0.0028]
["GWAS_Catalog","Response to serotonin reuptake inhibitors in major depressive disorder",16,2,0.0419]
["Mapped + eQTL genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,22,0.0298166671164726]
["GO_bp","GO_CELLULAR_COMPONENT_MORPHOGENESIS",1111,11,0.0015499999999999999]
["GO_bp","GO_NEURON_RECOGNITION",47,4,0.002]
["GO_bp","GO_NEUROGENESIS",1591,12,0.0023600000000000001]
["GO_bp","GO_NEURON_DIFFERENTIATION",1341,11,0.00249]
["GO_bp","GO_NEURON_DEVELOPMENT",1092,10,0.0025100000000000001]
["GO_bp","GO_BIOLOGICAL_ADHESION",1396,10,0.0184]
["GO_bp","GO_CIRCULATORY_SYSTEM_DEVELOPMENT",1134,9,0.020500000000000001]
["GO_bp","GO_REGULATION_OF_CELL_DEVELOPMENT",928,8,0.028400000000000002]
["GO_bp","GO_CELL_PART_MORPHOGENESIS",673,7,0.028400000000000002]
["GO_bp","GO_CELL_RECOGNITION",144,4,0.035000000000000003]
["GO_bp","GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS",1009,8,0.041099999999999998]
["GO_bp","GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",163,4,0.047199999999999999]
["GWAS_Catalog","Serum thyroid-stimulating hormone levels",26,3,0.0057400000000000003]
[]
[]
["DEG: differentially expressed gene"]
["GO_bp: gene ontology biological process"]

{"sheet":"Table7","index":6,"n_rows":34,"n_cols":5,"rows_kept":34,"cut":false,"hidden":false,"merged":[[3,0,3,4],[16,0,16,4]]}
["Overrepresented gene sets within ImmuneSet associations for the presence of psychosis in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,10,0.0272673709197923]
["GO_bp","GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",163,5,6.4838362764232761e-05]
["GO_bp","GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",268,5,0.0003889921276278201]
["GO_bp","GO_BIOLOGICAL_ADHESION",1396,7,0.0028786974122820782]
["GO_bp","GO_CELL_CELL_ADHESION",815,5,0.044199477590157979]
["GO_bp","GO_SYNAPSE_ORGANIZATION",403,4,0.044199477590157979]
["GO_bp","GO_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING",433,4,0.048747691747418005]
["GWAS_Catalog","Obesity-related traits",713,5,0.015100000000000001]
["GWAS_Catalog","Seasonality and depression",26,2,0.020400000000000001]
["GWAS_Catalog","Response to amphetamines",33,2,0.0264]
["GWAS_Catalog","Atrial fibrillation",238,3,0.027300000000000001]
["GWAS_Catalog","Diastolic blood pressure",640,4,0.027300000000000001]
["Mapped + eQTL genes"]
["DEG.up","Brain_Hippocampus",1907,9,0.00011227963639272601]
["DEG.up","Brain_Amygdala",1778,8,0.00073972068728302403]
["DEG.up","Brain_Anterior_cingulate_cortex_BA24",2312,8,0.0049418500779896601]
["DEG.up","Brain_Hypothalamus",2448,8,0.0074101468231139601]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,13,0.024458049307860701]
["DEG.up","Brain_Substantia_nigra",1600,6,0.032264362658428497]
["DEG.twoside","Brain_Cortex",8094,13,0.033135398999659602]
["DEG.up","Brain_Putamen_basal_ganglia",1692,6,0.043399076440010301]
["GO_bp","GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",163,5,0.00056899999999999995]
["GO_bp","GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",268,5,0.0033500000000000001]
["GO_bp","GO_BIOLOGICAL_ADHESION",1396,8,0.0051000000000000004]
["GO_bp","GO_CELL_CELL_ADHESION",815,6,0.024799999999999999]
["GO_bp","GO_POST_EMBRYONIC_ANIMAL_MORPHOGENESIS",12,2,0.044299999999999999]
[]
[]
["DEG: differentially expressed gene"]
["GO_bp: gene ontology biological process"]

{"sheet":"Table8","index":7,"n_rows":50,"n_cols":5,"rows_kept":50,"cut":false,"hidden":false,"merged":[[3,0,3,4],[11,0,11,4],[33,0,33,4]]}
["Overrepresented gene sets within ImmuneSet associations for the presence of substance and alcohol use disorders in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped + eQTL genes - Alcohol use disorder"]
["GWAS_Catalog","Alzheimer's disease or fasting glucose levels (pleiotropy)",50,6,1.3399999999999999e-09]
["GWAS_Catalog","Experiencing mood swings",40,4,1.3699999999999999e-05]
["GWAS_Catalog","Neuroticism",149,4,0.0018699999999999999]
["GWAS_Catalog","Suffering from nerves",5,2,0.0020300000000000001]
["GWAS_Catalog","Diisocyanate-induced asthma",173,4,0.0020300000000000001]
["GWAS_Catalog","Loneliness (MTAG)",73,3,0.0052100000000000002]
["GWAS_Catalog","Loneliness",100,3,0.0115]
["Mapped genes- Substance use disorder"]
["DEG.twoside","Brain_Cerebellum",8270,14,0.00021178747844472401]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,13,0.00128868009562597]
["DEG.twoside","Brain_Cortex",8094,12,0.0142723430682609]
["DEG.twoside","Brain_Anterior_cingulate_cortex_BA24",8789,12,0.033622300950509602]
["GO_bp","GO_CELL_CELL_ADHESION",815,7,0.0012887340619406667]
["GO_bp","GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",268,5,0.0012887340619406667]
["GO_bp","GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES",163,4,0.0051583224788097374]
["GO_bp","GO_NEURON_DIFFERENTIATION",1341,7,0.0096346875219079416]
["GO_bp","GO_BIOLOGICAL_ADHESION",1396,7,0.0097716759075899273]
["GO_bp","GO_AXON_DEVELOPMENT",507,5,0.0097716759075899273]
["GO_bp","GO_NEURON_PROJECTION_GUIDANCE",271,4,0.01482284000061636]
["GO_bp","GO_NEUROGENESIS",1591,7,0.01482284000061636]
["GO_bp","GO_NEURON_DEVELOPMENT",1092,6,0.016519433512041878]
["GO_bp","GO_TAXIS",631,5,0.016519433512041878]
["GO_bp","GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY",641,5,0.016519433512041878]
["GO_bp","GO_NEURON_CELL_CELL_ADHESION",15,2,0.019670041229042361]
["GO_bp","GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY",332,4,0.019670041229042361]
["GO_bp","GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE",21,2,0.035253758395874135]
["GO_bp","GO_ACTIVATION_OF_MAPK_ACTIVITY",152,3,0.043990033375843389]
["GWAS_Catalog","Chronotype",553,5,0.010999999999999999]
["GWAS_Catalog","Serum thyroid-stimulating hormone levels",26,2,0.047]
["Mapped + eQTL genes - Substance use disorder"]
["DEG.twoside","Brain_Amygdala",9265,20,0.0080481525195423894]
["DEG.twoside","Brain_Frontal_Cortex_BA9",7869,18,0.0126110001537204]
["DEG.twoside","Brain_Caudate_basal_ganglia",8801,19,0.0153584092877618]
["DEG.twoside","Brain_Cortex",8094,18,0.0186141843608446]
["DEG.twoside","Brain_Cerebellum",8270,18,0.024975514512113401]
["DEG.twoside","Brain_Hippocampus",9210,19,0.029620333266110799]
["DEG.twoside","Brain_Nucleus_accumbens_basal_ganglia",8591,18,0.041735176104650898]
["KEGG","KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM",76,3,0.012]
["KEGG","KEGG_CELL_ADHESION_MOLECULES_CAMS",130,3,0.029399999999999999]
["KEGG","KEGG_CALCIUM_SIGNALING_PATHWAY",177,3,0.048300000000000003]
["WikiPathways","Ras Signaling",185,4,0.02]
["WikiPathways","GPR40 Pathway",15,2,0.0287]
[]
[]
["DEG: differentially expressed gene"]
["GO_bp: gene ontology biological process"]

{"sheet":"Table9","index":8,"n_rows":23,"n_cols":5,"rows_kept":23,"cut":false,"hidden":false,"merged":[[3,0,3,4],[9,0,9,4]]}
["Overrepresented gene sets within ImmuneSet associations for the presence of suicide ideation in ConLiGen"]
[]
["Category","GeneSet","N_genes","N_overlap","adjP"]
["Mapped genes"]
["Canonical_Pathways","PID_RXR_VDR_PATHWAY",26,2,0.028684536038010487]
["GO_mf","GO_NUCLEAR_RECEPTOR_ACTIVITY",47,2,0.047023339730220257]
["GO_mf","GO_STEROID_HORMONE_RECEPTOR_ACTIVITY",56,2,0.047023339730220257]
["GO_mf","GO_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY",66,2,0.047023339730220257]
["Wikipathways","Nuclear Receptors",39,2,0.01612893285089171]
["Mapped + eQTL genes"]
["Canonical_Pathways","REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY",53,3,0.0012600000000000001]
["Canonical_Pathways","PID_RXR_VDR_PATHWAY",26,2,0.0344]
["GO_mf","GO_NUCLEAR_RECEPTOR_ACTIVITY",47,3,0.00055900000000000004]
["GO_mf","GO_STEROID_HORMONE_RECEPTOR_ACTIVITY",56,3,0.00055900000000000004]
["GO_mf","GO_SEQUENCE_SPECIFIC_DOUBLE_STRANDED_DNA_BINDING",858,4,0.043499999999999997]
["GO_mf","GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY",315,3,0.043499999999999997]
["GO_mf","GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING",932,4,0.043499999999999997]
["GO_mf","GO_DOUBLE_STRANDED_DNA_BINDING",949,4,0.043499999999999997]
["GO_mf","GO_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY",66,2,0.048099999999999997]
["Wikipathways","Nuclear Receptors",39,3,0.000122]
[]
[]
["GO_mf: gene ontology molecular function"]

{"sheet":"Table10","index":9,"n_rows":38,"n_cols":30,"rows_kept":38,"cut":false,"hidden":false,"merged":[[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,7],[2,8,3,8],[2,9,2,10],[2,11,2,12],[2,13,2,14],[2,15,2,16],[2,17,2,18],[2,19,2,20],[2,21,2,22],[2,23,2,24],[2,25,2,26],[2,27,2,28],[2,29,3,29]]}
["Information about the calculated PGSs and p-values obtained for the association with BP phenotypes"]
[]
["PGS Name","PGS Catalog ID","Phenotype","Method","Publication ID","Publication Year","# SNPs","# Valid SNPs","% SNP overlap","Li.Response  (N=853)",null,"Continuous.LiResp  (N=800)",null,"AAO  (N=853)",null,"Depression  (N=789)",null,"Hypomania  (N=101)",null,"Mania  (N=724)",null,"Psychosis  (N=692)",null,"Alcohol  (N=835)",null,"Substance  (N=832)",null,"Suicide  (N=660)",null,"# Assoc. Phenos"]
[{"$nulls":9},"estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval","estimate","Pval"]
["Autoimmune","PGS002629","Autoimmune disease","PolyFun-pred","PGP000332",2022,159127,61677,38.759607106273606,-0.084599999999999995,0.27979999999999999,-0.044999999999999998,0.67169999999999996,0.20730000000000001,0.50439999999999996,-0.0097000000000000003,0.94520000000000004,0.18529999999999999,"NA",-0.0258,0.79590000000000005,0.13900000000000001,0.1515,0.18559999999999999,0.086599999999999996,0.094399999999999998,0.37140000000000001,0.1197,0.18029999999999999,0]
["Lymphocytes","PGS000098","Lymphocyte percentage of white cells","Regularized Regression (Elastic Net)","PGP000051",2022,22363,10968,49.045298036936011,0.0608,0.43559999999999999,0.053400000000000003,0.62709999999999999,-0.37780000000000002,0.23280000000000001,-0.0068999999999999999,0.96489999999999998,0.33660000000000001,0.3286,-0.12959999999999999,0.23960000000000001,-0.0877,0.35770000000000002,-0.10349999999999999,0.35120000000000001,0.0574,0.59389999999999998,0.066900000000000001,0.4541,0]
["Monocytes","PGS000103","Monocyte percentage of white cells","Regularized Regression (Elastic Net)","PGP000051",2022,22843,11130,48.72389791183295,0.18479999999999999,0.0177,0.19900000000000001,0.062199999999999998,-0.0147,0.96299999999999997,0.26939999999999997,0.058799999999999998,-0.39739999999999998,0.36899999999999999,-0.1384,0.1862,-0.15329999999999999,0.091800000000000007,-0.14779999999999999,0.16059999999999999,-0.090200000000000002,0.38040000000000002,0.064000000000000001,0.45350000000000001,1]
["Neutrophils","PGS000106","Neutrophil percentage of white cells","Regularized Regression (Elastic Net)","PGP000051",2022,22049,10912,49.489772778810831,-0.0511,0.50880000000000003,-0.10290000000000001,0.32779999999999998,0.020799999999999999,0.94940000000000002,0.055399999999999998,0.69310000000000005,0.052699999999999997,0.8861,0.1358,0.18759999999999999,0.13619999999999999,0.159,0.085699999999999998,0.43090000000000001,0.0103,0.92249999999999999,-0.1215,0.17369999999999999,0]
["Eosinophils","PGS000091","Eosinophil percentage of white cells","Regularized Regression (Elastic Net)","PGP000051",2022,24406,11928,48.873227894779973,-0.077899999999999997,0.32069999999999999,-0.1134,0.31519999999999998,0.31890000000000002,0.36349999999999999,-0.0064000000000000003,0.96499999999999997,0.1208,0.7671,0.1045,0.30990000000000001,0.087400000000000005,0.34210000000000002,-0.062899999999999998,0.5575,-0.066600000000000006,0.52990000000000004,0.1741,0.047899999999999998,1]
["Basophils","PGS000089","Basophil percentage of white cells","Regularized Regression (Elastic Net)","PGP000051",2022,5248,2673,50.933689024390247,-0.059200000000000003,0.44319999999999998,-0.064799999999999996,0.5423,0.64100000000000001,0.031300000000000001,-0.26690000000000003,0.078,0.21609999999999999,0.37830000000000003,0.0060000000000000001,0.95530000000000004,-0.11899999999999999,0.2036,-0.13,0.2366,-0.066000000000000003,0.52600000000000002,-0.040300000000000002,0.64059999999999995,1]
["CCL20","PGS000220","CCL20 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,551989,446348,80.861756303114731,-0.0106,0.9042,0.22939999999999999,0.083699999999999997,0.26119999999999999,0.48209999999999997,0.046699999999999998,0.78029999999999999,1.1733,0.0135,0.012200000000000001,0.91520000000000001,0.052499999999999998,0.62739999999999996,-0.090200000000000002,0.45550000000000002,-0.12509999999999999,0.29330000000000001,-0.10440000000000001,0.31340000000000001,1]
["CCL3","PGS000221","CCL3 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552347,426637,77.240756263725515,-0.077399999999999997,0.32440000000000002,-0.082199999999999995,0.46879999999999999,-0.1391,0.64059999999999995,0.059999999999999998,0.67490000000000006,0.5534,0.2555,-0.062,0.54510000000000003,-0.0064999999999999997,0.94430000000000003,0.077799999999999994,0.45910000000000001,0.056500000000000002,0.59030000000000005,0.031800000000000002,0.70889999999999997,0]
["CCL4","PGS000222","CCL4 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552214,446498,80.855972503413525,0.12920000000000001,0.13789999999999999,0.1474,0.2366,-0.0378,0.91049999999999998,0.1227,0.4879,0.036700000000000003,0.94789999999999996,-0.079500000000000001,0.50680000000000003,-0.15559999999999999,0.13450000000000001,-0.050900000000000001,0.6774,-0.22220000000000001,0.061800000000000001,0.1444,0.13689999999999999,0]
["CD40","PGS000223","CD40 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552187,446544,80.868256586989546,0.030200000000000001,0.745,-0.16539999999999999,0.222,0.78449999999999998,0.033099999999999997,0.026700000000000002,0.87529999999999997,-0.5212,0.26519999999999999,-0.086800000000000002,0.48089999999999999,0.049299999999999997,0.65620000000000001,0.095200000000000007,0.47339999999999999,0.12859999999999999,0.31459999999999999,0.033099999999999997,0.74880000000000002,1]
["CHI3L1","PGS000224","CHI3L1 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552106,444649,80.536889655247364,0.1822,0.031899999999999998,0.093700000000000006,0.47160000000000002,0.1394,0.68259999999999998,-0.18110000000000001,0.27160000000000001,0.34339999999999998,0.504,-0.057500000000000002,0.61929999999999996,-0.062899999999999998,0.52859999999999996,-0.0137,0.90649999999999997,0.11849999999999999,0.29459999999999997,-0.16020000000000001,0.086099999999999996,1]
["CSF1","PGS000225","CSF-1 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,552163,446705,80.900929616797939,0.0339,0.74360000000000004,-0.0177,0.91239999999999999,0.30380000000000001,0.47139999999999999,0.024899999999999999,0.90249999999999997,-0.3579,0.39400000000000002,-0.097199999999999995,0.52649999999999997,0.031199999999999999,0.80079999999999996,-0.0016000000000000001,0.99070000000000003,-0.15310000000000001,0.28439999999999999,-0.025700000000000001,0.82279999999999998,0]
["CX3CL1","PGS000229","CX3CL1 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552274,446522,80.851533840086617,-0.023300000000000001,0.80720000000000003,-0.14019999999999999,0.3372,-0.026100000000000002,0.94779999999999998,0.22309999999999999,0.19639999999999999,-0.94899999999999995,0.034700000000000002,-0.0001,0.99929999999999997,-0.0080999999999999996,0.94379999999999997,-0.069800000000000001,0.6038,0.1087,0.40970000000000001,0.2054,0.058500000000000003,1]
["CXCL1","PGS000230","CXCL1 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552234,445397,80.653672175201095,-0.030499999999999999,0.71079999999999999,0.086599999999999996,0.45610000000000001,0.1046,0.74580000000000002,0.14660000000000001,0.38269999999999998,-0.064299999999999996,0.90569999999999995,-0.0625,0.54900000000000004,0.1144,0.23649999999999999,-0.12180000000000001,0.2918,0.057500000000000002,0.60450000000000004,-0.1119,0.22309999999999999,0]
["CXCL16","PGS000231","CXCL16 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552241,444958,80.573155560706283,-0.075300000000000006,0.33450000000000002,-0.060100000000000001,0.57730000000000004,-0.81669999999999998,0.010200000000000001,-0.1033,0.4587,-0.192,0.63260000000000005,-0.1007,0.32029999999999997,0.11559999999999999,0.20280000000000001,0.073099999999999998,0.49509999999999998,0.092999999999999999,0.3785,-0.019400000000000001,0.82230000000000003,1]
["CXCL6","PGS000232","CXCL6 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552061,444958,80.59942651264987,-0.075300000000000006,0.33450000000000002,-0.060100000000000001,0.57730000000000004,-0.81669999999999998,0.010200000000000001,-0.1033,0.4587,-0.192,0.63260000000000005,-0.1007,0.32029999999999997,0.11559999999999999,0.20280000000000001,0.073099999999999998,0.49509999999999998,0.092999999999999999,0.3785,-0.019400000000000001,0.82230000000000003,1]
["ECP","PGS000234","ECP serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,553046,451350,81.611656173265871,0.14699999999999999,0.091200000000000003,0.1908,0.1431,0.3392,0.35039999999999999,0.13150000000000001,0.42259999999999998,-0.28460000000000002,0.46789999999999998,0.0201,0.86570000000000003,0.055300000000000002,0.57769999999999999,-0.1323,0.28010000000000002,-0.027099999999999999,0.81879999999999997,-0.19359999999999999,0.041000000000000002,1]
["FAS","PGS000238","FAS serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.03","PGP000089",2020,552335,444796,80.530113065440361,0.021600000000000001,0.8034,0.083699999999999997,0.52549999999999997,0.35049999999999998,0.31280000000000002,0.441,0.0033999999999999998,-0.30480000000000002,0.43369999999999997,-0.1137,0.34789999999999999,0.090899999999999995,0.37509999999999999,0.010699999999999999,0.9284,0.20530000000000001,0.090700000000000003,-0.0068999999999999999,0.94230000000000003,1]
["GAL3","PGS000242","Gal-3 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.3","PGP000089",2020,552282,445205,80.61189754509472,0.076300000000000007,0.32940000000000003,-0.1046,0.32050000000000001,0.37630000000000002,0.20499999999999999,-0.11,0.45739999999999997,-0.87409999999999999,0.069900000000000004,-0.029499999999999998,0.75649999999999995,-0.042500000000000003,0.64390000000000003,-0.026700000000000002,0.80049999999999999,-0.067599999999999993,0.51429999999999998,0.0045999999999999999,0.95779999999999998,0]
["HSP27","PGS000248","HSP-27 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.3","PGP000089",2020,552212,446442,80.846124314574837,0.081500000000000003,0.31809999999999999,0.16689999999999999,0.16569999999999999,0.4002,0.23280000000000001,-0.0247,0.86209999999999998,-1.0089999999999999,0.0067000000000000002,-0.095399999999999999,0.376,-0.0053,0.95689999999999997,-0.0083999999999999995,0.94069999999999998,0.15559999999999999,0.15690000000000001,-0.081600000000000006,0.372,1]
["IL18","PGS000249","IL-18 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,552186,446413,80.84467914796825,0.031399999999999997,0.70109999999999995,0.058299999999999998,0.63670000000000004,-0.12089999999999999,0.70030000000000003,0.0241,0.87460000000000004,-0.12,0.76370000000000005,0.14330000000000001,0.22239999999999999,0.0023999999999999998,0.98060000000000003,0.089499999999999996,0.41060000000000002,-0.12820000000000001,0.2465,-0.1173,0.18770000000000001,0]
["IL1RA","PGS000250","IL-1ra serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,551917,445827,80.777906822946207,0.1142,0.1852,0.0235,0.85460000000000003,0.1691,0.63790000000000002,-0.14749999999999999,0.37109999999999999,0.065199999999999994,0.84930000000000005,0.15459999999999999,0.18240000000000001,0.060900000000000003,0.54339999999999999,-0.043099999999999999,0.71379999999999999,-0.085099999999999995,0.46210000000000001,-0.0055999999999999999,0.95369999999999999,0]
["IL27","PGS000251","IL-27 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.03","PGP000089",2020,552026,446175,80.824997373312129,-0.053400000000000003,0.50680000000000003,0.082699999999999996,0.45069999999999999,0.019599999999999999,0.95299999999999996,0.1716,0.2319,0.1167,0.76249999999999996,0.012500000000000001,0.91139999999999999,0.084500000000000006,0.3695,0.21299999999999999,0.056599999999999998,0.13769999999999999,0.2172,0.050099999999999999,0.57830000000000004,0]
["IL6","PGS000252","IL-6 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.003","PGP000089",2020,552426,445808,80.700039462299017,0.1353,0.099400000000000002,0.1908,0.093799999999999994,0.68559999999999999,0.038100000000000002,-0.217,0.13139999999999999,-0.1268,0.75049999999999994,-0.013899999999999999,0.90800000000000003,-0.010200000000000001,0.91539999999999999,-0.0077999999999999996,0.94589999999999996,-0.024899999999999999,0.82399999999999995,-0.014500000000000001,0.87470000000000003,1]
["IL6RA","PGS000253","IL-6RA serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,552132,445078,80.610795969079859,0.062300000000000001,0.4294,0.0419,0.72560000000000002,0.53320000000000001,0.074399999999999994,-0.0901,0.60309999999999997,0.30170000000000002,0.42370000000000002,-0.025899999999999999,0.8024,0.16639999999999999,0.0717,-0.0286,0.79049999999999998,0.035400000000000001,0.74690000000000001,0.010800000000000001,0.90300000000000002,0]
["IL8","PGS000254","IL-8 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.1","PGP000089",2020,551990,446110,80.81849308864291,-0.0178,0.82869999999999999,0.1041,0.37330000000000002,-0.84099999999999997,0.0047000000000000002,0.090200000000000002,0.58220000000000005,-0.4582,0.26550000000000001,-0.1021,0.35570000000000002,0.082199999999999995,0.39079999999999998,0.1017,0.36230000000000001,0.0683,0.5383,-0.076100000000000001,0.40400000000000003,1]
["TNFR1","PGS000287","TNF-R1 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.1","PGP000089",2020,552317,444776,80.529116431324766,-0.0057000000000000002,0.94830000000000003,-0.16520000000000001,0.1943,0.5181,0.15620000000000001,0.1739,0.31559999999999999,-0.090200000000000002,0.79369999999999996,0.0407,0.76819999999999999,-0.0044000000000000003,0.96589999999999998,0.027400000000000001,0.82450000000000001,0.025399999999999999,0.83040000000000003,0.023400000000000001,0.80820000000000003,0]
["TNFR2","PGS000288","TNF-R2 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,552185,444598,80.516131369015824,0.025499999999999998,0.75719999999999998,-0.062,0.5877,0.16819999999999999,0.61899999999999999,-0.0079000000000000008,0.95960000000000001,-0.1241,0.66679999999999995,-0.039699999999999999,0.74960000000000004,-0.047399999999999998,0.62709999999999999,0.0349,0.75629999999999997,-0.021000000000000001,0.8498,-0.040300000000000002,0.65869999999999995,0]
["TNFSF14","PGS000289","TNFSF14 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552048,445409,80.683020317073883,0.18859999999999999,0.028500000000000001,0.029899999999999999,0.82050000000000001,0.1918,0.54120000000000001,0.060900000000000003,0.6885,-0.48549999999999999,0.2359,0.023199999999999998,0.82740000000000002,0.1116,0.27110000000000001,0.071199999999999999,0.54969999999999997,0.0286,0.80410000000000004,-0.1212,0.19689999999999999,1]
["TRAIL","PGS000290","TRAIL serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.003","PGP000089",2020,552279,447392,81.008330934183633,-0.0424,0.57920000000000005,0.056099999999999997,0.61099999999999999,-0.038300000000000001,0.90149999999999997,-0.076899999999999996,0.55930000000000002,-0.066900000000000001,0.80820000000000003,0.15540000000000001,0.1144,-0.092499999999999999,0.32179999999999997,-0.084099999999999994,0.44940000000000002,-0.012500000000000001,0.90580000000000005,-0.1414,0.1084,0]
["TRAILR2","PGS000291","TRAIL-R2 serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 0.01","PGP000089",2020,552198,446189,80.802357125523812,0.0041999999999999997,0.96040000000000003,-0.077100000000000002,0.52029999999999998,0.38519999999999999,0.27660000000000001,0.29670000000000002,0.056000000000000001,-0.0025000000000000001,0.99590000000000001,-0.0207,0.86109999999999998,-0.19470000000000001,0.056599999999999998,-0.032500000000000001,0.78269999999999995,-0.029899999999999999,0.79449999999999998,-0.044499999999999998,0.63819999999999999,0]
["TRANCE","PGS000292","TRANCE serum levels","Ldpred. HapMap3 SNPs with MAF >0.05, HWE P>1e-05, imputation quality>0.95, fraction of causal markers 1","PGP000089",2020,552090,446430,80.861816008259524,-0.014200000000000001,0.89659999999999995,-0.1033,0.52390000000000003,-0.52839999999999998,0.19600000000000001,-0.15060000000000001,0.49409999999999998,-0.3407,0.57350000000000001,-0.070800000000000002,0.62529999999999997,-0.034099999999999998,0.7923,-0.17910000000000001,0.22570000000000001,-0.099099999999999994,0.50019999999999998,0.10150000000000001,0.40999999999999998,0]
[]
["nominally significant (p<0.05)"]