Fig.2A,,,,
labelname,model,c,lower,upper
Smoking,individual_CRF,0.527,0.502,0.551
Prevalent diabetes,individual_CRF,0.527,0.512,0.541
Exercise,individual_CRF,0.555,0.535,0.575
HDL,individual_CRF,0.575,0.543,0.607
Gut microbiome score,GMscore_strat_sex,0.578,0.547,0.610
Family history,individual_CRF,0.579,0.553,0.606
BMI,individual_CRF,0.591,0.561,0.620
Total cholesterol,individual_CRF,0.607,0.577,0.637
Systolic BP,individual_CRF,0.649,0.619,0.679
Baseline age,individual_CRF,0.719,0.695,0.743
Conventional risk factors (CRFs),all_crf,0.771,0.748,0.793
Gut microbiome score + CRFs,GMscore_crf_strat_sex,0.771,0.749,0.794
Shannon index + CRFs,Alpha_diversities_crf,0.771,0.748,0.794
ChaoShannon index + CRFs,Alpha_diversities_crf,0.771,0.748,0.794
chao1 + CRFs,Alpha_diversities_crf,0.771,0.748,0.794
evenness + CRFs,Alpha_diversities_crf,0.770,0.748,0.793
PC1 + CRFs,PCs_crf,0.771,0.748,0.794
PC2 + CRFs,PCs_crf,0.770,0.747,0.793
PC3 + CRFs,PCs_crf,0.772,0.749,0.794
PC4 + CRFs,PCs_crf,0.770,0.747,0.793
PC5 + CRFs,PCs_crf,0.771,0.748,0.793
,,,,
,,,,
Fig.2B,,,,
labelname,model,c,lower,upper
Smoking,individual_CRF,0.514,0.496,0.532
Exercise,individual_CRF,0.556,0.542,0.571
Total cholesterol,individual_CRF,0.558,0.534,0.582
Family history,individual_CRF,0.591,0.571,0.612
Gut microbiome score,GMscore_strat_sex,0.612,0.590,0.635
Systolic BP,individual_CRF,0.620,0.597,0.643
Baseline age,individual_CRF,0.625,0.605,0.646
HDL,individual_CRF,0.634,0.612,0.657
Triglyceride,individual_CRF,0.698,0.677,0.718
BMI,individual_CRF,0.745,0.726,0.764
Conventional risk factors (CRFs),all_crf,0.785,0.768,0.802
Gut microbiome score + CRFs,GMscore_crf_strat_sex,0.789,0.772,0.806
Shannon index + CRFs,Alpha_diversities_crf,0.785,0.768,0.803
ChaoShannon index + CRFs,Alpha_diversities_crf,0.785,0.768,0.803
chao1 + CRFs,Alpha_diversities_crf,0.785,0.768,0.802
evenness + CRFs,Alpha_diversities_crf,0.785,0.768,0.802
PC1 + CRFs,PCs_crf,0.785,0.768,0.802
PC2 + CRFs,PCs_crf,0.788,0.771,0.805
PC3 + CRFs,PCs_crf,0.786,0.769,0.803
PC4 + CRFs,PCs_crf,0.785,0.768,0.802
PC5 + CRFs,PCs_crf,0.786,0.769,0.803
,,,,
,,,,
Fig.2C,,,,
labelname,model,c,lower,upper
Prevalent psychiatric disorders,individual_CRF,0.510,0.498,0.522
Prevalent stroke,individual_CRF,0.515,0.503,0.528
HDL,individual_CRF,0.518,0.482,0.554
Diastolic BP,individual_CRF,0.520,0.485,0.554
Prevalent T2D,individual_CRF,0.523,0.508,0.538
Smoking,individual_CRF,0.540,0.518,0.561
Exercise,individual_CRF,0.543,0.521,0.565
Total cholesterol,individual_CRF,0.577,0.543,0.611
Gut microbiome score,GMscore_strat_sex,0.581,0.546,0.616
BMI,individual_CRF,0.610,0.578,0.642
Alcohol consumption,individual_CRF,0.617,0.584,0.651
Systolic BP,individual_CRF,0.656,0.623,0.688
Baseline age,individual_CRF,0.880,0.864,0.895
Conventional risk factors (CRFs),all_crf,0.883,0.868,0.899
Gut microbiome score + CRFs,GMscore_crf_strat_sex,0.883,0.868,0.899
Shannon index + CRFs,Alpha_diversities_crf,0.883,0.868,0.899
ChaoShannon index + CRFs,Alpha_diversities_crf,0.883,0.868,0.898
chao1 + CRFs,Alpha_diversities_crf,0.883,0.868,0.899
evenness + CRFs,Alpha_diversities_crf,0.883,0.868,0.899
PC1 + CRFs,PCs_crf,0.883,0.868,0.898
PC2 + CRFs,PCs_crf,0.883,0.868,0.898
PC3 + CRFs,PCs_crf,0.883,0.868,0.899
PC4 + CRFs,PCs_crf,0.883,0.868,0.899
PC5 + CRFs,PCs_crf,0.883,0.868,0.898
,,,,
,,,,
Fig.2D,,,,
labelname,model,c,lower,upper
Alcohol consumption,individual_CRF,0.512,0.467,0.557
Exercise,individual_CRF,0.518,0.483,0.553
BMI,individual_CRF,0.544,0.502,0.587
Family history,individual_CRF,0.554,0.513,0.595
Smoking,individual_CRF,0.565,0.534,0.596
Gut microbiome score,GMscore_strat_sex,0.623,0.581,0.666
Baseline age,individual_CRF,0.769,0.739,0.798
Conventional risk factors (CRFs),all_crf,0.773,0.744,0.802
Gut microbiome score + CRFs,GMscore_crf_strat_sex,0.778,0.750,0.807
Shannon index + CRFs,Alpha_diversities_crf,0.773,0.744,0.803
ChaoShannon index + CRFs,Alpha_diversities_crf,0.773,0.744,0.803
chao1 + CRFs,Alpha_diversities_crf,0.783,0.755,0.810
evenness + CRFs,Alpha_diversities_crf,0.774,0.745,0.803
PC1 + CRFs,PCs_crf,0.773,0.744,0.802
PC2 + CRFs,PCs_crf,0.776,0.747,0.804
PC3 + CRFs,PCs_crf,0.776,0.747,0.806
PC4 + CRFs,PCs_crf,0.775,0.747,0.804
PC5 + CRFs,PCs_crf,0.774,0.745,0.803